Journal articles on the topic 'Probiotics'
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Ramadhana, Sri, Noor Arida Fauzana, and Pahmi Ansyari. "PEMBERIAN PAKAN KOMERSIL DENGAN PENAMBAHAN PROBIOTIK YANG MENGANDUNG Lactobacillus sp. TERHADAP KECERNAAN DAN PERTUMBUHAN IKAN NILA (Oreochromis niloticus) (THE ADDITION OF PROBIOTICS CONTAINING Lactobacillus Sp. IN THE COMMERCIAL ON DIGESTIBILITY AND GROWTH OF NILE TILAPIA (OREOCHROMIS NILOTICUS)." Fish Scientiae 2, no. 4 (June 17, 2016): 178. http://dx.doi.org/10.20527/fs.v2i4.1173.
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Tujuan dari penelitian ini adalah untuk mengetahui efek pemberian probiotik yang mengandung Lactobacillus sp. dalam pakan komersial terhadap kualitas pakan, meningkatkan jumlah bakteri dalam mukosa usus dan kecernaan ikan melalui pemberian pakan probiotik yang ramah lingkungan, mengetahui dosis efektif probiotik dalam pakan yang dapat menunjang pertumbuhan ikan nila (Oreocromis niloticus). Penelitian ini dilaksanakan selama 6 (enam) bulan, mulai bulan September 2012 sampai Februari 2013. Rancangan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap dengan 4 (Empat) perlakuan dan 3 (Tiga) ulangan, yaitu perlakuan A (Kontrol), B (Probiotik 3%), C (Probiotik 5%) dan D (Probiotik 7%).Hasil penelitian menunjukkan bahwa pemberian pakan dengan penambahan probiotik yang mengandung Lactobacillus sp. menggunakan dosis sebesar 3%, 5% dan 7% mampu meningkatkan kandungan gizi, pakan, dengan nilai protein antara 32,48%-34,19% dan menurunkan serat kasar dengan nilai antara 5,04%-5,70% dibandingkan tanpa pemberian probiotik. Pemberian probiotik dalam pakan dengan persentase 3%, 5%, dan 7% dapat meningkatkan kecernaan ikan nila pakan efektif untuk meningkatkan pertumbuhan berat dan panjang ikan nila.The purpose of this research was to determine the effect of probiotics in commercial feed on feed quality, enhance increase bactery number in gut mucose and digestibility of nile tilapia (Oreocromis niloticus) through the provision of environmental friendly probiotic feed, determine the effective doses of probiotics infeed that can support the growth fish. The research was conducted for 6 (six) months, from September 2012 until February 2013. The design used in this study was completely randomized design with 4 (four) treatments and 3 (three) replicates, were treatment A (control), B (Probiotics 3%), C (Probiotics 5%) and D (Probiotic 7%).The results showed that the addition of probiotic containing Lactobacillus sp. feeding with doses of 3%, 5% and 7% were able to improve the nutritional content, protein values between 32,48%-34,19% and lower crude fiber with values between 5,04-5,70% compared with no probiotics. The addition of probiotics in feed with a percentage of 3%, 5%, and 7% can increase digestibility of nile tilapia and effective to increase the nile weight and length growth of nile tilapia.
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Tampangallo, Bunga Rante, Ike Trismawanti, and Muliani Muliani. "KELAYAKAN PENGGUNAAN PROBIOTIK RICA KEMASAN SERBUK UNTUK PEMELIHARAAN PASCA LARVA UDANG WINDU Penaeus monodon DALAM BAK TERKONTROL." Media Akuakultur 13, no. 2 (October 30, 2018): 91. http://dx.doi.org/10.15578/ma.13.2.2018.91-98.
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Probiotik RICA kemasan cair telah diaplikasikan pada pemeliharaan udang windu P. monodon maupun vaname Litopenaeus vannamei. Namun, probiotik kemasan cair dirasa banyak mengalami kendala dalam hal pengiriman. Alternatif bentuk kemasan yang saat ini sedang dikaji adalah bentuk kemasan serbuk. Penelitian ini bertujuan mengetahui viabilitas probiotik RICA setelah dikemas dalam bentuk serbuk, waktu penyimpanan, serta pengaruhnya terhadap sintasan dan pertumbuhan benih udang windu yang dipelihara dalam bak terkontrol. Penelitian dilakukan dalam dua tahap, yakni penepungan probiotik, pengamatan populasi probiotik, dan aplikasinya pada pemeliharaan udang windu. Wadah pemeliharaan udang windu menggunakan bak fiber volume 500 liter. Udang uji yang digunakan adalah udang windu PL-12 dengan kepadatan 200 ekor per bak. Penelitian menggunakan rancangan acak lengkap empat perlakuan tiga ulangan. Perlakuan menggunakan probiotik serbuk RICA-4 (A), (B) probiotik RICA-5, (C), probiotik RICA-1, dan (D) tanpa probiotik. Hasil penelitian menunjukkan bahwa populasi probiotik RICA setelah diserbukkan berkisar 107 sel/mL. Sintasan, bobot, dan panjang udang windu setelah dipelihara selama 48 hari dengan menggunakan probiotik RICA serbuk belum memberikan hasil yang signifikan (P>0,05), namun pemberian probiotik RICA telah meningkatkan total hemolim udang windu secara signifikan (P<0,05) dibanding kontrol. Pada aplikasi probiotik ini terjadi pertumbuhan lumut dalam bak pemeliharaan akibat penggunaan tepung kanji sebagai filler.RICA probiotics have been tested in multiple farms of black tiger shrimp P. monodon and whiteleg shrimp Litopenaeus vannamei with some promising results. However, the probiotics’ distribution in the form of liquid faces some limitations due to transportation regulations involving liquid-based substances. A powder form might be an easy and secure alternatively for the distribution of the probiotics via airplane. The purpose of the study was to observe the viability of RICA probiotics after powdering and storage as well as their influences on the survival and growth rates of black tiger shrimp reared in controlled tanks. The study was conducted in three stages which were the powdering of the probiotic, observation of the probiotics’ bacteria population, and its application in shrimp rearing. The research was designed in a completely randomized design where 200 shrimps aged PL-12 reared in each tank and applied with three different powder probiotics namely (A) RICA-4, (B) RICA-5, and (C) RICA-1 as the treatments, and (D) without adding probiotic as a control. The result showed that the probiotic population after powdering ranged around 107 cells/mL. The survival rate, body length, and weight of shrimps after 48 days of rearing showed insignificant results (P>0.05) among the treatment. However, RICA-1 had an increase in the total of hemocytes of the shrimps (P<0.05) compared to control. The emergence of moss in the containers became a constraint during the experiment.
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Znamenska, T. K., and O. V. Vorobiova. "DO PROBIOTICS HAVE ANY FUTURE IN NEONATOLOGY? (ANALYSIS OF THE LATEST DATA. PART I) T. K. Znamenska, O. V. Vorobiova." Neonatology, surgery and perinatal medicine 11, no. 2(40) (October 19, 2021): 53–59. http://dx.doi.org/10.24061/2413-4260.xi.2.40.2021.8.
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From year to year prescription of probioticsremains a controversial issue both in medicine for adults andpediatrics. Some doctors make a positive conclusion about theeffectiveness of probiotics, while large individual tests beinga part of meta-analyses show negative results pointing that acertain probiotic strain has no influence on a patient. It’s betterto avoid excessively negative or positive conclusions CRTabout probiotics. The issue of using probiotics in newborns isespecially acute among neonatologists. The aim of this articleis the analysis of the latest data on the possibility of usingprobiotics in newborns.In 2021 the clinical report about the use of probiotics inpremature newborns in the USA was published (ААР committeeon fetus and newborns issue). It pointed out that the numberof premature newborns who get prescriptions for probiotics,namely in the USA, is steadily increasing despite significantdifferences in combinations of probiotic drugs and absenceof pharmaceutical class of probiotic products. Accordingto the latest source of database in the USA, around 10% ofnewborns with extremely low gestational age get a certaintype of probiotics while being in the intensive care unit fornewborns with different variations among the units. Despitethe fact that lots of doctors argue their usual use of probioticsin premature newborns, other groups, including ESPGHANand АРР are more cautious admitting the main restrictions ofmany researches, methodological differences in the design ofa research and guidelines along with the conclusion that theeffectiveness of probiotics may vary widely.Recently the ESPGHAN working group on probiotics andprebiotics has published the document on using an approachof network meta-analysis of finding strains with the largestpotential of effectiveness to prevent major diseases inpremature newborns. Following this the ESPGHAN committeeon feeding issue and the ESPGHAN working group onprobiotics and prebiotics have an aim to develop a documentwhich can serve as a guidance for possible use of probiotics inpremature newborns the positions of which we will consider inthe second part of the article.
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Muhakka, Muhakka, A. Wijaya, and M. Ammar. "Nutritional Dried Matter, Crude Protein and Crude Fiber on Lowland Tidal Grass Fermented by Probiotic Microorganisms for Use Bali Cattle Feed." ANIMAL PRODUCTION 17, no. 1 (January 24, 2015): 24. http://dx.doi.org/10.20884/1.anprod.2015.17.1.478.
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Abstract. This study was aimed to determine nutritional value of lowland tidal grass fermented by probiotic microorganisms. This study used a completely randomized design and investigated two factors, namely varieties of lowland tidal grass (kumpai tembaga (Ischaemum rugosum), kumpai minyak (Hymenachne amplexicaulis) and kumpai padi (Oryza rufipogon)) and probiotic microorganism concentration (0.3, 0.5, 0.7 and 0.9 percent). The following parameters were observed, including dried matter content, crude protein content and crude fiber content. The results showed that the use of probiotics have significant effects on crude protein content and crude fiber content. In conclusion, the use of probiotics can improve the nutritional value of grass. The best result was obtained on kumpai tembaga grass (Ischaemum rugosum) fermented with 0.7% probiotic microorganism. Keywords: nutritional evaluation, lowland tidal grass, fermentation, probiotics microorgansms Abstrak. Penelitian ini bertujuan untuk menentukan nilai nutrisi rumput tidal dataran rendah yang difermentasi menggunakan mikroba probiotik. Penelitian menggunakan rancangan acak lengkap dan mengamati dua faktor, yaitu varitas rumput tidal dataran rendah (kumpai tembaga (Ischaemum rugosum), kumpai minyak (Hymenachne amplexicaulis) dan kumpai padi (Oryza rufipogon)) dan mikroba probiotik (0,3; 0,5; 0,7 dan 0,9 persen). Parameter yang diamati meliputi kandungan bahan kering, protein kasar, dan serat kasar. Hasilnya menunjukkan bahwa penggunaan probiotik memiliki pengaruh nyata terhadap kandungan protein kasar dan serat kasar. Dapat disumpulkan bahwa penggunaan probiotik dapat meningkatkan nilai nutrisi dari rumput. Hasil terbaik diperoleh pada rumput kumpai tembaga (Ischaemum rugosum) yang difermentasi menggunakan 0,7% mikroba probiotik. Kata kunci: evaluasi nutrisi, rumput tidal dataran rendah, fermentasi, mikroba probiotik
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Muhakka, Muhakka, A. Wijaya, and M. Ammar. "Nutritional Dried Matter, Crude Protein and Crude Fiber on Lowland Tidal Grass Fermented by Probiotic Microorganisms for Use Bali Cattle Feed." ANIMAL PRODUCTION 17, no. 1 (January 24, 2015): 24. http://dx.doi.org/10.20884/1.jap.2015.17.1.478.
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Abstract. This study was aimed to determine nutritional value of lowland tidal grass fermented by probiotic microorganisms. This study used a completely randomized design and investigated two factors, namely varieties of lowland tidal grass (kumpai tembaga (Ischaemum rugosum), kumpai minyak (Hymenachne amplexicaulis) and kumpai padi (Oryza rufipogon)) and probiotic microorganism concentration (0.3, 0.5, 0.7 and 0.9 percent). The following parameters were observed, including dried matter content, crude protein content and crude fiber content. The results showed that the use of probiotics have significant effects on crude protein content and crude fiber content. In conclusion, the use of probiotics can improve the nutritional value of grass. The best result was obtained on kumpai tembaga grass (Ischaemum rugosum) fermented with 0.7% probiotic microorganism. Keywords: nutritional evaluation, lowland tidal grass, fermentation, probiotics microorgansms Abstrak. Penelitian ini bertujuan untuk menentukan nilai nutrisi rumput tidal dataran rendah yang difermentasi menggunakan mikroba probiotik. Penelitian menggunakan rancangan acak lengkap dan mengamati dua faktor, yaitu varitas rumput tidal dataran rendah (kumpai tembaga (Ischaemum rugosum), kumpai minyak (Hymenachne amplexicaulis) dan kumpai padi (Oryza rufipogon)) dan mikroba probiotik (0,3; 0,5; 0,7 dan 0,9 persen). Parameter yang diamati meliputi kandungan bahan kering, protein kasar, dan serat kasar. Hasilnya menunjukkan bahwa penggunaan probiotik memiliki pengaruh nyata terhadap kandungan protein kasar dan serat kasar. Dapat disumpulkan bahwa penggunaan probiotik dapat meningkatkan nilai nutrisi dari rumput. Hasil terbaik diperoleh pada rumput kumpai tembaga (Ischaemum rugosum) yang difermentasi menggunakan 0,7% mikroba probiotik. Kata kunci: evaluasi nutrisi, rumput tidal dataran rendah, fermentasi, mikroba probiotik
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Weiner, Noam, and Ron Shaoul. "Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children." Global Pediatric Health 2 (January 1, 2015): 2333794X1560779. http://dx.doi.org/10.1177/2333794x15607798.
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The primary objective of this study was to evaluate the effect of age, gender, and the use of probiotics with standard treatment regimen on Helicobacter pylori eradication. Based on endoscopic findings and clinical presentation, selected patients were treated with standard triple therapy (omeprazole, clarithromycin, and amoxicillin). Those who failed were offered a repeat treatment with omeprazole, metronidazole, and amoxicillin. After the publications of the possible advantages of probiotic treatment on H pylori eradication, the probiotic agent “Probiotica Forte” was routinely added to the treatment. Eradication was noted for 94/130 patients (72%) and for 128/197 patients (65%) with or without probiotic agent, respectively ( P = .23). For second-line treatment eradication was noted in 33/46 (72%) and in 9/20 (45%) with or without probiotic agent, respectively ( P = .053). The addition of probiotics may improve eradication success especially in addition to second-line treatment.
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Andreev, V. A., Olga U. Stetsiouk, and Irina V. Andreeva. "Probiotics: controversial issues." Clinical Microbiology and Antimicrobial Chemotherapy 24, no. 4 (2022): 345–60. http://dx.doi.org/10.36488/cmac.2022.4.345-360.
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Recent studies have strongly confirmed the health benefits of a variety of probiotic microorganisms. However, some issues regarding the use of probiotics currently remain unresolved or ambiguous. This article highlights some controversial issues of probiotic use in clinical practice such as regulatory status of probiotics, co-administration of probiotics and antibiotics, potential impact of probiotics on antimicrobial resistance emergence and spread, dosing and duration of probiotic use, contraindications and some other debatable topics.
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Han, Le Nguyen, Le Huynh Hong Van, Tran Van Duc, and Dong Thi Anh Dao. "ENCAPSULATION OF LACTOBACILLUS ACIDOPHILUS IN YEAST CELL WALLS (SACCHAROMYCES CEREVISIAE) FOR IMPROVING SURVIVAL IN GASTROINTESTINAL CONDITIONS." Vietnam Journal of Science and Technology 54, no. 4 (August 18, 2016): 533. http://dx.doi.org/10.15625/0866-708x/54/4/7422.
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In search of high-quality health products, it is required that probiotic preparations consumed in gastro-intestinal condition remain metabolically active and preserve their activity. Several recent studies, consequently, have focused on probiotic protection via encapsulation in order to optimize probiotics’ viability as well as their delivery into gastro-intestinal environment. The objectives of this study were to find out a new material for encapsulation of probiotics, utilizing capsules prepared from Saccharomyces cerevisiae to protect living probiotic cells. The encapsulation of cells was achieved, using the crack scars of the yeast cell walls (YCW) created by the sonication method. Besides, some probiotic cells can be considered as being encapsulated by some surrounded yeast cells by direct cell-cell contact. It is concluded that thanks to encapsulation by yeast cells, probiotic’s metabolic activity and survival are markedly improved. This suggests a high potential in protecting probiotics from the extreme condition of digestion process and can be applied in protecting probiotic preparations in food formulations as well. It was found that encapsulation yield in this study reached its highest point at 82.008 ± 1.123%. Viability of encapsulated probiotic in simulated gastric juice (SGJ) after 150 minutes is 19.048 ± 2.701%, compared to that of free cells at 0%. Likewise, after a 4-hour treatment in simulated intestinal juice (SIJ) (0.5% bile salt) encapsulated probiotic proves better survival at 56.338 ± 5.094% than free cell at 43.677 ± 2.058%.
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Hyseni, Edita, and Marija Glavas Dodov. "Probiotics in dermatological and cosmetic products – application and efficiency." Macedonian Pharmaceutical Bulletin 68, no. 1 (January 25, 2023): 9–26. http://dx.doi.org/10.33320/maced.pharm.bull.2022.68.01.002.
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The term “probiotics” has first been used in 1907 by Elie Metchnikoff. Since then, probiotics have been part of research not only in regards of digestive health, but also inflammatory diseases. Lately, there has been an increased interest of probiotic’s effects in skincare. The management of atopic dermatitis, acne, psoriasis, photo aging, skin cancer, intimate care, oral care, wound healing is getting harder each passing day, due to increased antibiotic resistance and other side effects of conventional therapy. Therefore, new ingredients have been investigated and probiotics have been proved to be effective in treating various skin conditions. This review aims to evaluate the scientific evidence on topical and oral probiotics, and to evaluate the efficacy of cosmetic and dermatological products containing probiotics. Many studies have shown that skin and gut microbiome alterations have an important role in skin health. Although this is a new topic in dermatology and cosmetology, there have been some promising results in lots of research studies that the use of probiotics in cosmetic products may help improve the patient’s outcome. While oral probiotics have been shown to promote gut health, which influences the host immune system and helps treat different skin diseases, the mechanism of action of topical probiotics is not yet fully understood. Although the number of commercial probiotic cosmetic products released in the market is increasing and most of the studies have not shown any serious side effect of probiotics, further studies, in larger and heterogeneous groups are needed.
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Hadist, Ibrahim. "PENGARUH PEMBERIAN HERBAL YANG MENGANDUNG PROBIOTIK DALAM AIR MINUM TERHADAP PALATABILITAS RANSUM AYAM BROILER The Effect of Herbs That Contain Probiotics in Drinking Water on Broiler Chicken Feed Palatability." JANHUS: Jurnal Ilmu Peternakan Journal of Animal Husbandry Science 1, no. 1 (December 1, 2016): 1. http://dx.doi.org/10.52434/janhus.v1i1.320.
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Abstrak
Penelitian bertujuan untuk mengetahui sampai sejauh mana pengaruh pemberian herbal yang mengandung probiotik dalam air minum terhadap konsumsi ransum segar,konsumsi bahan kering, konsumsi energi ransum, konsumsi protein ransum, dan konsumsi serat kasar ransum pada ternak ayam broiler. Penelitian ini menggunakan 100 ekor DOC broiler yang ditempatkan secara acak kedalam 20 kandang, dan setiap kandang terdiri dari 5 ekor ayam. Penelitian menggunakan metode experimental dengan Rancangan Acak Lengkap (RAL) dengan empat perlakuan air minum dan lima ulangan. Perlakuan air minum yang digunakan yaitu air minum yang tidak mengandung probiotik 0% (R1); mengandung vitamin dan antibiotik (R2); mengandung 1 ml herbal yang mengandung probiotik (R3); dan mengandung 2 ml herbal yang mengandung probiotik (R4). Hasil penelitian menunjukan bahwa penambahan herbal yang mengandung probiotik tidak berpengatuh terhadap palatabilitas ransum ayam broiler.
Kata kunci : herbal, probiotik, air minum, palatabilitas, ayam broiler
Abstract
The object of study was evaluate the extent of the effect of herbs that contain probiotics in drinking water on feed consumption, dry matter intake, feed energy consumption, the consumption of dietary protein, and crude fiberconsumption in broiler chickens. This reseach used 100 broiler at one days of age, were randomly placed into 20 cages, each cage consisted of five chickens. The methode of research was experimental designed by completely randomized design (CRD) with four treatments and five replications of drinking water. The treatments consisted of drinking water that does not contain probiotics 0% (R1); drinking water were contain vitamins and antibiotics (R2); drinking water were contain 1 ml herbs with probiotics (R3); drinking water were contain 2 ml herbs with probiotics (R4). The results showed that the addition of herbs that contain probiotics do not affect the feed palatability of broiler chicken.
Keywords : Herb, probiotic, drinking water, palatability, broiler chicken
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Kamil, M. Ihsan, Maya Istyadji, and Yasmine Khairunnisa. "The Effect of Use of Commercial Probiotics in Feed on Water Quality and Growth Performance of Bawal Fish (Colossoma Macropomum) Bioflok System." Scholars International Journal of Biochemistry 6, no. 06 (July 23, 2023): 79–85. http://dx.doi.org/10.36348/sijb.2023.v06i06.001.
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Biofloc consists of special substances called probiotics, where probiotics contain beneficial microorganisms in cultivation activities. Probiotics can be given through feed and water (media). Probiotics can break down metabolic waste and stimulate an immune response so that fish health increases and affects growth. Probiotics have an effect on the growth of ti- lapia, but there is no information for freshwater pomfret. This study aims to determine the ef-fect of probiotic types on biofloc volume, water quality, and fish growth in pomfret culture (Colossoma macropomum) biofloc system. The method used was giving different types of probiotics, treatment A control, B EM4, C Probiotic-7, D Aquaenzym. The results of the re-search showed that the lowest pH of the system was 7.85, namely the pH of the probiotic-7 type. The mean floc growth measurement results for treatment A was 12.93, treatment B was 17.54, treatment C was 17.59, treatment D was 15.98. Aquaenzym probiotic has a fish surviv-al rate of 100% compared to other probiotics. The type of probiotic that has the best results in increasing the growth performance of freshwater pomfret (Colossoma macropomum) is probiotic-7.
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Li, Lu. "Probiotics and Probiotic Foods." International Journal of Food Science and Agriculture 7, no. 1 (May 6, 2023): 143–46. http://dx.doi.org/10.26855/ijfsa.2023.03.019.
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Hastuti, Dewi A. R., Johnny L. Rompis, and Jeanette I. Ch Manoppo. "Pengaruh Pemberian Probiotik terhadap Neonatus dengan Hiperbilirubinemia." Medical Scope Journal 5, no. 2 (July 21, 2023): 208–13. http://dx.doi.org/10.35790/msj.v5i2.45410.
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Abstract: Hyperbilirubinemia is a medical condition that is often found in the first week of neonates. The usual treatment for hyperbilirubinemia is phototherapy, however, many studies revealed probiotics as another form of treatment. Probiotics are live microorganisms that have similarities to the normal intestinal flora. They are believed to reduce enterohepatic cycle activity which can reduce serum bilirubin in neonates with hyperbilirubinemia. This study aimed to determine the effect of probiotics on neonates with hyperbilirubinemia. This was a literature review study using three different databases, namely Pubmed, Google Scholar, and ClinicalKey. The results obtained 10 literatures carried out from related inclusion and exclusion selections. After reviewing the ten literatures, it was found that the most widely used probiotic genus was Lactobacillus where the strain that had the greatest influence was Lactobacillus reuteri. Six out of ten literatures stated that probiotics had significant effect as a treatment for neonates with hyperbilirubinemia due to their capability to reduce the total serum bilirubin. In conclusion, probiotics may affect the treatment of neonates with hyperbilirubinemia. Keywords: probiotics; hyperbilirubinemia; neonates Abstrak: Hiperbilirubinemia merupakan salah satu kondisi medis yang sering dijumpai pada seminggu pertama pada neonatus. Pengobatan yang biasa diberikan pada hiperbilirubinemia ialah fototerapi, namun saat ini telah banyak penelitian mengenai probiotik sebagai bentuk pengobatan lainnya. Probiotik merupakan mikroorganisme hidup yang memiliki kesamaan dengan flora normal usus dan dipercaya dapat menurunkan aktivitas siklus enterohepatik dan selanjutnya bilirubin serum pada neonatus yang mengalami hiperbilirubinemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian probiotik pada neonatus dengan hiperbilirubinemia. Jenis penelitian ialaah suatu literature review berdasarkan pencarian melalui tiga database yaitu Pubmed, Google Scholar, dan ClinicalKey. Hasil penelitian mendapatkan 10 literatur yang telah dilakukan seleksi kriteria inklusi dan eksklusi terkait. Dari 10 jurnal yang telah diulas, didapatkan bahwa genus probiotik yang paling banyak digunakan ialah Lactobacillus, dan strain yang memiliki pengaruh terbesar yaitu Lactobacillus reuteri. Enam dari 10 literatur menyatakan bahwa pemberian probiotik dapat berpengaruh bermakna sebagai pengobatan neonatus dengan hiperbilirubinemia karena probiotik dapat membantu menurunkan nilai total serum bilirirubin. Simpulan penelitian ini ialah probiotik dapat memengaruhi pengobatan neonatus dengan hiperbilirubinemia. Kata kunci: probiotik; hiperbilirubinemia; neonatus
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Adejumo, Samson Adedeji, Angus Nnamdi Oli, Adekunle Babajide ROWAIYE, Nwamaka Henrietta IGBOKWE, Chinelo Kene EZEJIEGU, and Zwanden Sule YAHAYA. "Immunomodulatory Benefits of Probiotic Bacteria: A Review of Evidence." OBM Genetics 07, no. 04 (December 11, 2023): 1–73. http://dx.doi.org/10.21926/obm.genet.2304206.
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Over the past few decades, probiotics have emerged as a viable medical tool for preventing and/or treating diseases. This narrative review provides recent findings on Probiotics and their benefits on the host immune system. It also highlights the specific mechanisms through which probiotics mediate those benefits. The study also explores the topical or systemic probiotic administration method. Authors screened databases like Google Scholar, Web of Science, PubMed, Scopus, and China National Knowledge Infrastructure database, using various keyword combinations such as: “probiotic” AND “Immunomodulation” OR “probiotic” AND “Immunoregulation” OR “probiotic” AND “Immunostimulation”, for relevant literature written in English only. The review shows that probiotics can regulate the host immune system, including regulating T cells, dendritic cells, intestinal epithelial cells, and several signal pathways, and confer health benefits. Although several clinical trials also revealed the prospects and efficacy of probiotics as immunomodulators and treatment of diseases, there is a need for thorough future investigations on the effectiveness of specific strains of probiotics involved in immunomodulation.
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van den Nieuwboer, M., and E. Claassen. "Dealing with the remaining controversies of probiotic safety." Beneficial Microbes 10, no. 6 (July 10, 2019): 605–16. http://dx.doi.org/10.3920/bm2018.0159.
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A clear safety profile of probiotics in clinical practice is essential in decision-making for all stakeholders and regulators. Probiotics have been investigated in different target populations, conditions and age groups. This also includes the use of probiotics in critically ill patients. Despite promising results reported with the use of probiotics and synbiotics, there is still a lively discussion regarding the proper and safe use of probiotics among physicians, researchers and regulators. This doubt and debate was sparked by the high incidence in mortality reported in a study with critically ill patients. Whereas no causal relationship has been established since, safety of probiotic has been questioned. In response, an overwhelming body of evidence suggesting that probiotics are safe has been compiled. Moreover, data indicates that probiotics reduce the number of adverse events compared to the control. However, due to a lack of standardised safety reporting in clinical studies, a strong evidence base on probiotic safety remains to be established. Here, we will discuss: (1) the rationale for using probiotics in the critically ill; (2) what happened during the Dutch Pancreatitis trial; (3) what are the known safety risks of probiotics based on the available data; and finally (4) how standardisation in safety reporting can drive probiotic innovation. Building a strong safety profile for probiotic strains will solidify its use in individuals that can benefit the most from microbial modulation.
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Olson, Douglas W., and Kayanush J. Aryana. "Probiotic Incorporation into Yogurt and Various Novel Yogurt-Based Products." Applied Sciences 12, no. 24 (December 8, 2022): 12607. http://dx.doi.org/10.3390/app122412607.
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Probiotics are commonly added to yogurt to provide many health benefits for the consumer. A description is provided for some commonly used probiotics in yogurt. A GRAS (generally recognized as safe) list of probiotic bacteria that can be added to yogurt or similar types of products is provided. Additionally, prebiotics, synbiotics (combination of prebiotics and probiotics), postbiotics, paraprobiotics, and psychobiotics can be added to yogurt. Probiotic yogurt can come in various forms in addition to spoonable yogurt, and yogurt can be used as an ingredient in other food products. Many useful functional ingredients can be applied to probiotic yogurt. The safety of probiotics must be addressed, especially for critically ill patients and other susceptible populations. Probiotics must survive within yogurt throughout its entire shelf-life and within the gastrointestinal tract after consumption by the consumer to provide health benefits, and many techniques can be used to maintain survival of probiotics in yogurt. Furthermore, probiotics can be added to Greek yogurt acid whey. Many opportunities exist for adding a wide variety of probiotics to a wide variety of yogurt-based products.
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Liu, Zhen-Shu, Pei-Lin Li, Yu-We Ku, and Po-Wen Chen. "Oral Administration of Recombinant Lactoferrin-Expressing Probiotics Ameliorates Diet-Induced Lipid Accumulation and Inflammation in Non-Alcoholic Fatty Liver Disease in Mice." Microorganisms 10, no. 11 (November 9, 2022): 2215. http://dx.doi.org/10.3390/microorganisms10112215.
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We have recently developed probiotics that can express bovine, human, or porcine lactoferrin (LF), and the present study evaluated the effect of these probiotics in improving non-alcoholic fatty liver disease (NAFLD). Three kinds of probiotic supplements, including lactic acid bacteria (LAB), LAB/LF, and inactivated LAB/LF, were prepared. The LAB supplement was prepared from 10 viable LAB without recombinant LF-expression, the LAB/LF supplement was prepared from 10 viable probiotics expressing LF, and the inactivated LAB/LF supplement was prepared from 10 inactivated probiotics expressing LF. A model of obese/NAFLD mice induced by a high-fat diet was established, and the mice were randomly divided into four groups and fed with a placebo, LAB, LAB/LF, or inactivated LAB daily for four weeks via oral gavage. The body weight, food intake, organ weight, biochemistry, and hepatic histopathological alterations and severity scoring were measured. The results revealed that the obese mice fed with any one of the three probiotic mixtures prepared from recombinant probiotics for four weeks exhibited considerably improved hepatic steatosis. These findings confirmed the assumption that specific probiotic strains or LF supplements could help to control NAFLD, as suggested in previous reports. Our data also suggest that the probiotics and LFs in probiotic mixtures contribute differently to improving the efficacy against NAFLD, and the expressed LF content in probiotics may help to boost their efficacy in comparison with the original probiotic mixtures. Moreover, when these LF-expressing probiotics were further inactivated by sonication, they displayed better efficacies than the viable probiotics against NAFLD. This study has provided intriguing data supporting the potential of recombinant probiotics in improving hepatic steatosis.
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Wang, Anyi, and Qixin Zhong. "Drying of probiotics to enhance the viability during preparation, storage, food application, and digestion: A review." Comprehensive Reviews in Food Science and Food Safety 23, no. 1 (December 31, 2023): 1–30. http://dx.doi.org/10.1111/1541-4337.13287.
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AbstractFunctional food products containing viable probiotics have become increasingly popular and demand for probiotic ingredients that maintain viability and stability during processing, storage, and gastrointestinal digestions. This has resulted in heightened research and development of powdered probiotic ingredients. The aim of this review is to overview the development of dried probiotics from upstream identification to downstream applications in food. Free probiotic bacteria are susceptible to various environmental stresses during food processing, storage, and after ingestion, necessitating additional materials and processes to preserve their activity for delivery to the colon. Various classic and emerging thermal and nonthermal drying technologies are discussed for their efficiency in preparing dehydrated probiotics, and strategies for enhancing probiotic survival after dehydration are highlighted. Both the formulation and drying technology can influence the microbiological and physical properties of powdered probiotics that are to be characterized comprehensively with various techniques. Furthermore, quality control during probiotic manufacturing and strategies of incorporating powdered probiotics into liquid and solid food products are discussed. As emerging technologies, structure‐design principles to encapsulate probiotics in engineered structures and protective materials with improved survivability are highlighted. Overall, this review provides insights into formulations and drying technologies required to supplement viable and stable probiotics into functional foods, ensuring the retention of their health benefits upon consumption.
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Coqueiro, Audrey Yule, Amanda Beatriz de Oliveira Garcia, Marcelo Macedo Rogero, and Julio Tirapegui. "Probiotic supplementation in sports and physical exercise: Does it present any ergogenic effect?" Nutrition and Health 23, no. 4 (December 2017): 239–49. http://dx.doi.org/10.1177/0260106017721000.
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Background: Probiotics are live microorganisms that promote health benefits to the host. Evidence indicates that some probiotic strains play an immunomodulatory role and reduce the incidence of respiratory and gastrointestinal infections in athletes and in physical activity practitioners. For this reason, probiotic supplementation could indirectly improve exercise performance. However, recent studies have observed direct ergogenic effects of probiotics, but the mechanisms of action are poorly elucidated. Objective: In this study, we aim to synthesize available knowledge on the effect of probiotics on physical exercise, identify the mechanisms of action by which probiotics could improve performance directly and indirectly, and verify whether probiotics have any ergogenic effect. Methods: The study was performed in the PubMed database in February 2017, without limitation as to the publication period. The keyword combinations used were: ‘Probiotics’ and ‘Sports’ ( n = 17 articles), ‘Probiotics’ and ‘Exercise’ ( n = 26 articles) and ‘Probiotics’ and ‘Athletes’ ( n = 11 articles). Results: Of the 16 studies evaluated, only six applied performance tests, of which only two demonstrated that probiotic supplementation increases performance, but one of them was performed with mice. Conclusions: According to the studies evaluated, probiotic supplementation does not present ergogenic effect, however, considering the small number of studies, this subject should be better investigated.
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Ozdener-Poyraz, Ayse Elif, Anastasia Rivkin, Otito Frances Iwuchukwu, and Daniel Cassino. "Bridging the gap between evidence-based practice and probiotic utilization among US adults: Results from a national survey." American Journal of Pharmacotherapy and Pharmaceutical Sciences 1 (November 4, 2022): 5. http://dx.doi.org/10.25259/ajpps_5_2022.
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Objectives: Recently published guidelines recommend probiotics for only a few indications. However, probiotics are widely utilized by consumers due to accessibility, perceived safety, and belief that they promote gut health. The objective of this survey study was to examine probiotic use, evaluate public knowledge regarding the risks and benefits of probiotics, and identify variables that predict the use of probiotics among US adults. Materials and Methods: The survey was conducted among a random sample of 1000 adults living in the US, from January 28 through February 13, 2019. Analysis was conducted with Chi-square tests and Pearson correlation with 95% confidence intervals and a significance level of 5% for all tests. Multivariate logistic regression was used to identify associations between survey respondents’ characteristics and use of probiotics. Results: Thirty-one percent of respondents stated they currently take or have taken probiotics daily, while 29% are considering future use. Sixty-four percent of daily probiotic users were taking probiotics without a medical provider’s recommendation. Six percent sought counseling from a pharmacist for over-the-counter products, including probiotics. A multivariate logistic regression showed that women, whites, 4-year college graduates, and younger respondents were more likely to report probiotic use. An additional logistic regression showed a significant conditional relationship between chronic illness, education, and white race (P<0.05). Conclusion: Guideline-recommended indications for probiotic use are limited. This study showed some respondents may be using probiotics unnecessarily. Pharmacists can educate the public about probiotic benefits and prevent unnecessary use of these products.
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Soni, Yogesh, Preeti Sangwan, Neha Sharma, Priyanka Ahirwar, and Sahdev Kamboj. "Regulatory Status of Probiotics in India: A Current Scenario." EAS Journal of Pharmacy and Pharmacology 5, no. 03 (June 8, 2023): 73–77. http://dx.doi.org/10.36349/easjpp.2023.v05i03.005.
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Probiotics are employed in therapeutic settings and for consumers who are typically healthy. However, probiotic intake can have both hypothetical and real negative effects. Probiotics should be used safely and effectively, which calls for clear, doable suggestions on how to proceed in light of the introduction of new probiotic strains and products as well as the expansion of their usage among vulnerable groups. The International Scientific Association for Probiotics and Prebiotics called a meeting to discuss and develop evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the necessity of adverse event reporting related to probiotic use, and the importance of probiotic product quality to match the needs of vulnerable populations. In the present review we focused the ICMR- DBT guidelines for the evaluation of the probiotics and current regulatory status with reference to the probiotics.
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Hung, Yuan-Pin, Ching-Chi Lee, Jen-Chieh Lee, Pei-Jane Tsai, Po-Ren Hsueh, and Wen-Chien Ko. "The Potential of Probiotics to Eradicate Gut Carriage of Pathogenic or Antimicrobial-Resistant Enterobacterales." Antibiotics 10, no. 9 (September 8, 2021): 1086. http://dx.doi.org/10.3390/antibiotics10091086.
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Probiotic supplements have been used to decrease the gut carriage of antimicrobial-resistant Enterobacterales through changes in the microbiota and metabolomes, nutrition competition, and the secretion of antimicrobial proteins. Many probiotics have shown Enterobacterales-inhibiting effects ex vivo and in vivo. In livestock, probiotics have been widely used to eradicate colon or environmental antimicrobial-resistant Enterobacterales colonization with promising efficacy for many years by oral supplementation, in ovo use, or as environmental disinfectants. In humans, probiotics have been used as oral supplements for infants to decease potential gut pathogenic Enterobacterales, and probiotic mixtures, especially, have exhibited positive results. In contrast to the beneficial effects in infants, for adults, probiotic supplements might decrease potentially pathogenic Enterobacterales, but they fail to completely eradicate them in the gut. However, there are several ways to improve the effects of probiotics, including the discovery of probiotics with gut-protection ability and antimicrobial effects, the modification of delivery methods, and the discovery of engineered probiotics. The search for multifunctional probiotics and synbiotics could render the eradication of “bad” Enterobacterales in the human gut via probiotic administration achievable in the future.
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Lusiastuti, Angela Mariana, Septyan Andriyanto, and Reza Samsudin. "EFEKTIVITAS KOMBINASI PROBIOTIK MIKROENKAPSULASI MELALUI PAKAN UNTUK PENGENDALIAN PENYAKIT MOTILE AEROMONADS SEPTICEMIA PADA IKAN LELE, Clarias gariepinus." Jurnal Riset Akuakultur 12, no. 2 (October 19, 2017): 179. http://dx.doi.org/10.15578/jra.12.2.2017.179-186.
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Penelitian ini bertujuan untuk mengetahui efektivitas kombinasi probiotik mikroenkapsulasi melalui pakan dalam pengendalian penyakit pada ikan lele, Clarias gariepinus. Penelitian dilakukan mulai dari penyiapan kombinasi probiotik Bacillus cereus ND2 dan Staphylococcus lentus L1K, mikroenkapsulasi probiotik, uji probiotik mikroenkapsulasi, serta uji dosis secara in vivo. Proses mikroenkapsulasi menggunakan BUCHI mini spray dryer dengan suhu inlet 131°C-133°C dan suhu outlet 65°C-70°C. Pakan yang digunakan adalah pakan buatan dengan kadar protein 38% yang dicampur dengan probiotik mikroenkapsulasi sesuai dengan dosis perlakuan dan diberi putih telur 2% sebagai binder. Perlakuan yang dilakukan adalah membandingkan secara in vivo probiotik mikroenkapsulasi (PM) dan probiotik non-mikroenkapsulasi (PNM), dan dilanjutkan pengujian dosis melalui pakan untuk memperoleh dosis terbaik dari aplikasi probiotik mikroenkapsulasi. Parameter pengamatan berupa tingkat sintasan, biomassa, kadar hematokrit, hemoglobin, respiratory burst activity, dan total bacterial count. Hasil penelitian menunjukkan bahwa suplementasi kombinasi probiotik mikroenkapsulasi Bacillus cereus ND2 dan Staphylococcus lentus L1K pada pakan lebih efektif, dan dengan dosis 2% menunjukkan hasil yang lebih baik dalam meningkatkan sintasan hingga 97,33%, biomassa dan respons imun (NBT assay, hematocrit, hemoglobin) ikan lele terhadap A. hydrophila.This study was aimed to know the effectivity of microencapsulated probiotic combinations administered through diet to control motile aeromonads septicemia disease in catfish (Clarias gariepinus). The research stages consisted of preparation probiotics, microencapsulation of probiotics and probiotic microencapsulation testing in vivo. BUCHI mini spray dryer was used in the microencapsulation process with inlet temperature ranged between 131°C-133°C and outlet temperature ranged between 65°C-70°C. The diets used in the research were pelleted feeds with a protein content of 38% and mixed with different dosages of microencapsulated probiotics. Egg albumen (2%) was used to bind the mixture. The effectivity of microencapsulated and non-microencapsulated feeds was compared in order to find an optimum microencapsulation dosage. The observed parameters were survival rate, biomass, hematocrit, hemoglobin, respiratory burst activity, and total bacterial count. The results showed that the supplementation of microencapsulated probiotic Bacillus cereus ND2 and Staphylococcus lentus L1K in the diets was more effective at a dose of 2%, showing better survival rate (97.33%), biomass gain, and immune responses (NBT assay, hematocrit, hemoglobin) against A. hydrophila in catfish Clarias gariepinus.
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Safitri, Ratu, Yuli Andriani, Sunendi Sunendi, Iskandar Iskandar, and Ibnu Dwi Buwono. "EFFECT OF POWDER AND LIQUID PREPARATIONS OF PROBIOTICS ON WHITE SHRIMP (Litopenaeus vannamei) GROWTH PERFORMANCE." BIOTROPIA 27, no. 3 (December 23, 2020): 199–208. http://dx.doi.org/10.11598/btb.0.0.0.1124.
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Indonesia is the second largest supplier of white shrimp (Litopenaeus vannamei, Boone 1931) in the USA market. Hence, the need for its sustainable production and improved growth. Probiotics, among others, are known for their growth enhancing attributes. Therefore, this study was conducted to determine the effects of powder and liquid probiotics on the growth of white shrimps at the Minaloka Jaya shrimp ponds, Grabag District, Purwerojo Regency, Central Java. The shrimps were cultivated for 60 days and applied with three probiotic treatments, namely commercial liquid probiotics with dosage of 10 mL/kg feed, powder probiotics with dosage of 10 g/kg feed and liquid probiotic with dosage of 10 mL/kg feed. Each probiotic preparation was administered four times a day to over 150,000 vannamei shrimps which were cultured in a semi-intensive system. Probiotics in powder and liquid forms contain Lactobacillus fermentum, L acidophilus, L. plantarum, L, curvatus, Bacillus licheniformis, B. subtilis, and B. polimyxa. B. megaterium, B. coagulans, Pseudomonasputida, Nitrosomonas sp. and Nitrobacter sp. Using the Randomized Block Design (RBD), the three treatments were replicated five times. The application of probiotics in both powder and liquid forms had increased the growth yield of the vannamei shrimp. However, the powder probiotic had shown better growth performance than the commercial liquid probiotics and liquid preparation of probiotics. Probiotic powder form provides a specific growth rate (SGR) of 8.18%, absolute body length of 9.68 cm, absolute biomass of 6.78 g, and feed conversion ratio (FCR) of 1.93.
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Wijayanto, Agus, Hadijah Hadijah, and Sri Mulyani. "ANALISIS PENGGUNAAN FERMENTASI PROBIOTIK PADA PAKAN TERHADAP PRODUKTIFITAS UDANG VANAME (Litopenaeus vannamei)." Journal of Aquaculture and Environment 2, no. 2 (June 5, 2020): 27–29. http://dx.doi.org/10.35965/jae.v2i2.488.
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Beberapa tahun terakhir pembudidaya udang Vaname sudah meninggalkan penggunaan antibiotik untuk membantu mengatasi penyakit dalam upaya meningkatkan hasil panen, karena terbukti penggunaan bakteri menjadi semakin meningkatkan resistensi bakteri patogen terhadap antibiotik. Probiotik menjadi solusi terbaik saat ini untuk mendapatkan keberhasilan optimal pada hasil produksi budidaya udang Vaname. Tujuan dari penelitian ini supaya memperoleh pengetahuan konsentrasi terbaik penggunaan probiotik yang diberikan dengan pencampuran pakan dengan berbeda konsentrasi untuk pertumbuhan, sintasan dan FCR udang vaname (Litopenaeus vannamei). Metode yang digunakan pada penelitian ini eksperimental yang terdiri atas 4 perlakuan yaitu A (tanpa penambahan probiotik fermentasi pada pakan), B (penambahan probiotik fermentasi 0,5 liter), C (pakan dengan Probiotik fermentasi 1 liter), dan P3 (pakan dengan Probiotik fermentasi 1,5 liter) pada wadah dengan kepadatan 100 ekor/L. Hasil penelitian menunjukkan rata-rata laju pertumbuhan spesifik udang Vaname berkisar antara 0.16-0,26 %, tingkat kelangsungan hidup berkisar antara 49 – 93 %. In the last few years, vaname shrimp farmers have abandoned the use of antibiotics to help overcoming the disease as an effort to increase crop yields, because it is proven that the use of bacteria has increased the resistance of pathogenic bacteria to antibiotics. Probiotics are the best solution at this time to obtain optimal success in the production of vaname shrimp. The purpose of this study is to obtain the best concentration of probiotic use given by mixing feed with different concentrations for growth, survival and FCR of vaname shrimp (Litopenaeus vannamei). The method used in this experimental study consisted of 4 treatments namely A (without addition of fermented probiotics in feed), B (addition of 0.5-liter fermented probiotics), C (feed with 1-liter fermented probiotics), and P3 (feed with 1.5-liter fermented probiotics) in containers with a density of 100 ind./L. The results showed that the average specific growth rate of vaname shrimp ranged from 0.16 to 0.26% and the survival rate ranged from 49 to 93%.
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Peng, Yunjuan, Routing Chen, Zhihao Zhang, Rui Jin, Ting Xie, Xinting Liu, Jianmin Chai, et al. "Metagenomic and Meta-Transcriptomic Analysis Reveal the Colonization and Expression Profile of Probiotic Strains in Humans and Animals." Fermentation 9, no. 5 (April 26, 2023): 417. http://dx.doi.org/10.3390/fermentation9050417.
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In humans and animals, probiotics are widely accepted as crucial for host health and growth. The investigation of the probiotic colonization and expression of probiotics in the host is beneficial for proper usage of probiotics and isolation of indigenous probiotics. In this study, we analyzed commonly used probiotic strains in the intestines/rumen of humans and animals by analyzing metagenomic and paired meta-transcriptomic data from the gut or rumen microbiome of humans (n = 13), pigs (n = 6), chickens (n = 6), cattle (n = 14), sheep (n = 10), and mice (n = 8). First, we generated an expression profile based on 192 selected representative probiotic strains from a published database. A total of 58 probiotic strains were not detected in any samples, while 3 strains were presented and expressed in all individuals. Overall, the probiotic expression of probiotics as detected by meta-transcriptome was significantly higher than the relative abundance of probiotic as detected by metagenomics in cattle, sheep, mice, and humans; however, this difference was not significant in pigs and chickens. In total, 17 (cattle), 21 (sheep), 22 (pig), 14 (chicken), 13 (mouse), and 3 (human) probiotic strains were identified as probiotic strains with significantly higher expression levels [Fold Change (FC) ≥ 2, False Discovery Rate (FDR) ≤ 0.05]. Among them, Clostridium butyricum TOA was found to be significantly expressed in the rumen or gut of all host species. In addition, network analysis based on the expression of probiotics as detected by meta-transcriptomics revealed that several probiotic strains were significantly negatively linked with Salmonella spp., Mycoplasma spp., and Escherichia coli. The results in this study provide a useful reference for developing indigenous probiotics.
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Bergamini, Carlo M., Nicoletta Bianchi, Valerio Giaccone, Paolo Catellani, Leonardo Alberghini, Alessandra Stella, Stefano Biffani, Sachithra Kalhari Yaddehige, Tania Bobbo, and Cristian Taccioli. "Machine Learning Algorithms Highlight tRNA Information Content and Chargaff’s Second Parity Rule Score as Important Features in Discriminating Probiotics from Non-Probiotics." Biology 11, no. 7 (July 7, 2022): 1024. http://dx.doi.org/10.3390/biology11071024.
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Probiotic bacteria are microorganisms with beneficial effects on human health and are currently used in numerous food supplements. However, no selection process is able to effectively distinguish probiotics from non-probiotic organisms on the basis of their genomic characteristics. In the current study, four Machine Learning algorithms were employed to accurately identify probiotic bacteria based on their DNA characteristics. Although the prediction accuracies of all algorithms were excellent, the Neural Network returned the highest scores in all the evaluation metrics, managing to discriminate probiotics from non-probiotics with an accuracy greater than 90%. Interestingly, our analysis also highlighted the information content of the tRNA sequences as the most important feature in distinguishing the two groups of organisms probably because tRNAs have regulatory functions and might have allowed probiotics to evolve faster in the human gut environment. Through the methodology presented here, it was also possible to identify seven promising new probiotics that have a higher information content in their tRNA sequences compared to non-probiotics. In conclusion, we prove for the first time that Machine Learning methods can discriminate human probiotic from non-probiotic organisms underlining information within tRNA sequences as the most important genomic feature in distinguishing them.
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Haukioja, Anna. "Probiotics and Oral Health." European Journal of Dentistry 04, no. 03 (July 2010): 348–55. http://dx.doi.org/10.1055/s-0039-1697851.
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The number of products containing probiotics, viable bacteria with proven health benefits, entering the market is increasing. Traditionally, probiotics have been associated with gut health, and most clinical interest has been focused on their use for prevention or treatment of gastrointestinal infections and diseases; however, during the last decade several investigators have also suggested the use of probiotics for oral health purposes. The aim of this review is to examine potential mechanisms of probiotic bacteria in the oral cavity and summarize observed effects of probiotics with respect to oral health. The review focuses on probiotic lactobacilli and bifidobacteria, genera that are most used in various probiotic products. (Eur J Dent 2010;4:348-355)
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Wu, Shaoping, Sonia Yoon, Yong-Guo Zhang, Rong Lu, Yinglin Xia, Jiandi Wan, Elaine O. Petrof, Erika C. Claud, Di Chen, and Jun Sun. "Vitamin D receptor pathway is required for probiotic protection in colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 309, no. 5 (September 1, 2015): G341—G349. http://dx.doi.org/10.1152/ajpgi.00105.2015.
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Low expression of vitamin D receptor (VDR) and dysfunction of vitamin D/VDR signaling are reported in patients with inflammatory bowel disease (IBD); therefore, restoration of VDR function to control inflammation in IBD is desirable. Probiotics have been used in the treatment of IBD. However, the role of probiotics in the modulation of VDR signaling to effectively reduce inflammation is unknown. We identified a novel role of probiotics in activating VDR activity, thus inhibiting inflammation, using cell models and VDR knockout mice. We found that the probiotics Lactobacillus rhamnosus strain GG (LGG) and Lactobacillus plantarum (LP) increased VDR protein expression in both mouse and human intestinal epithelial cells. Using the VDR luciferase reporter vector, we detected increased transcriptional activity of VDR after probiotic treatment. Probiotics increased the expression of the VDR target genes, such as antimicrobial peptide cathelicidin, at the transcriptional level. Furthermore, the role of probiotics in regulating VDR signaling was tested in vivo using a Salmonella-colitis model in VDR knockout mice. Probiotic treatment conferred physiological and histologic protection from Salmonella-induced colitis in VDR+/+mice, whereas probiotics had no effects in the VDR−/−mice. Probiotic treatment also enhanced numbers of Paneth cells, which secrete AMPs for host defense. These data indicate that the VDR pathway is required for probiotic protection in colitis. Understanding how probiotics enhance VDR signaling and inhibit inflammation will allow probiotics to be used effectively, resulting in innovative approaches to the prevention and treatment of chronic inflammation.
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Meijerink, M., A. Mercenier, and J. M. Wells. "Challenges in translational research on probiotic lactobacilli: from in vitro assays to clinical trials." Beneficial Microbes 4, no. 1 (March 1, 2013): 83–100. http://dx.doi.org/10.3920/bm2012.0035.
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Beneficial effects of certain probiotic strains have been established in the treatment and prevention of various immune and intestinal disorders in humans, including allergic diseases, chronic inflammatory diseases and diarrhoea. The proposed mechanisms underlying the immunomodulatory effects of probiotics in humans are not understood in precise detail but include enhancement of intestinal barrier function, altered epithelial signalling, competition with pathogens and effects on immune cells and immunity depending on the probiotic strain. The publication of controversial or inconclusive probiotic studies in humans highlights the need for a better understanding of the mechanisms and improved strain selection criteria. This review focuses on the immunomodulatory properties of lactobacilli and bifidobacteria in vitro and in vivo, current knowledge concerning the mechanisms in vivo and challenges in translational research on probiotics. A better understanding of the molecular mechanisms of probiotics, the effect of probiotic mixtures versus single strains, the effect of formulation of probiotics and the fate of ingested probiotics should help to clarify the value of immune assays as selection criteria for probiotics.
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Znamenska, T., and O. Vorobiova. "DO PROBIOTICS HAVE A FUTURE IN NEONATOLOGY? (ANALYSIS OF THE LATEST DATA. PART 3)." Neonatology, surgery and perinatal medicine 11, no. 4(42) (December 15, 2021): 45–52. http://dx.doi.org/10.24061/2413-4260.xi.4.42.2021.8.
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The issue of feasibility and effectiveness of probiotics use in newborns is still discussable. A position letter of the Committee on nutrition of the European Society for Pediatric NutritionGastroenterology, Hepatology, and(ESPGHAN) and the Working group of the ESPGHAN on probiotics and prebiotics issues was published in May 2020 in “Pediatric Gastroenterology and Nutrition” magazine as for the use of probiotics in premature newborns. The third part of the literature continues with the position paper and the results of many randomized controlled clinical trials of probiotics. The article considers the answers to 6 clinical questions posed by the working group of the Committee to assess the feasibility of use, routes of administration, dosage and duration of use, as well as the effectiveness and quality of probiotic drugs. It was proved that probiotics, in general, could decrease the level of necrotising enterocolitis, sepsis, and mortality. On the other hand, an increasing number of commercial products containing probiotics of non optimal quality are available. In addition, a large number of departments in the world regularly suggest probiotic supplements as a treatment standard despite the absence of any solid evidence. Moreover, the emphasis was placed on issues of safety of probiotic supplements for premature newborns. Guarantee of quality of probiotic product is deliverance of probiotic strains by transfer genes of resistance to antibiotics, the ability to regularly detect sepsis while using probiotics.
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Ranjan, Kolli Guna, Girija Sankar G., and D. V. V. Satyanarayana Raju. "In vitro Evaluation of Antibacterial, Cytotoxic and Adherence Studies of Selected Commercial Probiotics." Journal of Pure and Applied Microbiology 14, no. 3 (September 7, 2020): 2085–91. http://dx.doi.org/10.22207/jpam.14.3.49.
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There is increasing scientific evidence and commercial interest for using probiotics for eliminating and handling of specific diseases. Probiotics can be evaluated for its role and performance against isolated pathogens from contaminating sources. The present work reports on invitro antimicrobial activity of commercial selected probiotics against pathogenic microbe Vibrio parahaemolyticus. The work also describes cytotoxic activities using MTT assay and adherence studies of selected probiotics. Results for the studies showed maximum zone of inhibition 13.66±0.46mm in probiotic enteroplus,12.33±0.93mm in lactobacillus (NCIM2056) and 10.66±0.93mm in Avant Bact. Cytotoxicity was expressed as IC50(µg/ml) values, observed on CaCO cell lines for different probiotics. Avant Bact showed a IC50 value of 104.7745, Lactobacillus (NCIM2056) a value of 58.13223 and Enteroplus a value of 50.09716. These values expressed different safety aspects of probiotics used for study. Finally the adherence study was done to check probiotic colonizing capacity. The probiotics showed varied adherence capacity against caco cell lines. Enteroplus has % adhesion of 10.25±0.74, Avant Bact. 7.25±0.82 and Lactobacillus (NCIM2056) 7.5±1.12. In conclusion antimicrobial results show importance of probiotics to be used against specific gastro intestinal diseases. Cytotoxicity determines safety aspects of probiotics and adherence study determines probiotic as a promising candidate for in vivo studies.
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Wolfe, William, Ze Xiang, Xi Yu, Ping Li, Hao Chen, Mingfei Yao, Yiqiu Fei, Yilun Huang, Yeshi Yin, and Hang Xiao. "The Challenge of Applications of Probiotics in Gastrointestinal Diseases." Advanced Gut & Microbiome Research 2023 (January 18, 2023): 1–10. http://dx.doi.org/10.1155/2023/1984200.
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Gastrointestinal disease is characterized by gastrointestinal dysfunction with dysbiosis of the microbiome. Probiotics may act as biological agents in treating gastrointestinal diseases through modifying gut microbiota. However, several challenges, including safety, stress resistance, postcolonization quantification, and evaluation models, may hinder the application of probiotics in gastrointestinal diseases. This review introduces the emerging methods for delivering probiotics as well as available materials. Furthermore, we elucidated bacteriocins and their role in helping probiotics obtain a competitive advantage over other strains and challenges of large-scale application. Bacteriocins produced by probiotics also showed promising efficacy in gastrointestinal diseases including the capacity of immune stimulation, intestinal barrier protection, and cytotoxicity against intestinal tumorigenesis. For the quantification of probiotics in complex microbiomes and evaluation methods of probiotic encapsulated delivery systems, recent fluorescent labeling technology and various in vitro and in vivo models were also reviewed. Given the widespread use of probiotic agents in the microecological therapy of gastrointestinal diseases, further understanding of the multiple challenges of probiotic application and the updated methods to improve the colonization and evaluation system of probiotics is of great significance for probiotics as live biotherapeutics.
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Liu, Mingkang, Jinjin Chen, Ida Putu Wiweka Dharmasiddhi, Shiyi Chen, Yilan Liu, and Hongmei Liu. "Review of the Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications." Processes 12, no. 2 (February 2, 2024): 316. http://dx.doi.org/10.3390/pr12020316.
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Probiotics, living microorganisms with demonstrated health benefits when administered in sufficient quantities, have a rich history as dietary supplements to benefit human health. Recently, understanding of their mechanisms in the gastrointestinal tract has prompted exploration of probiotics in treating human diseases. However, the effective and precise delivery of probiotics remains a significant challenge in therapeutic applications. Here, we review the mechanisms of action of probiotics in human health and the most advanced strategies for efficient probiotic delivery. We also discuss the potential applications of engineered probiotics in disease treatment. This review contributes insights into the evolving landscape of probiotic research for therapeutic applications.
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Mantziari, Anastasia, Satu Tölkkö, Artur C. Ouwehand, Eliisa Löyttyniemi, Erika Isolauri, Seppo Salminen, and Samuli Rautava. "The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro." Nutrients 12, no. 1 (January 9, 2020): 182. http://dx.doi.org/10.3390/nu12010182.
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Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used probiotics. The study covered two forms of human milk fortifier, liquid and powdered, with or without probiotics and storage at 4 °C for 24 h. To test the adhesion properties of the probiotic strains, DHM+probiotics and FDHM+probiotics were prepared and added to immobilized mucus isolated from the stool of healthy Finnish infants. The probiotic adhesion was then measured by liquid scintillation. Our results suggest that addition of liquid or powdered human milk fortifier in donor human milk had no impact on probiotic adhesion. In addition, given the increased adhesion of probiotics suspended in buffer, other matrices should be further studied. These factors need to be considered when designing future intervention strategies using probiotics in preterm infants.
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Warman, Indra, and Novita Hamron. "EKSPLORASI PROBIOTIK LOKAL UNTUK PERBAIKAN PEMBIBITAN DAN PEMBESARAN LELE SANGKURIANG." AGRITEPA: Jurnal Ilmu dan Teknologi Pertanian 7, no. 1 (May 27, 2020): 13–21. http://dx.doi.org/10.37676/agritepa.v7i1.1000.
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ABSTRACT
Catfish is one type of freshwater fish that is quite popular with the people of Indonesia. Catfish prices are relatively cheap, easily cultivated, and have high nutritional content. Efforts to improve the yield of catfish farming have been done in many different ways, one of which is probiotics. The purpose of giving probiotics is to improve water quality. The study was conducted from April to July 2019, in the Experimental Pool of the Faculty of Agriculture, University of Ratu Samban, Bengkulu Utara, Bengkulu Province. The study used a two-factor randomized block design. The first factor is the type of probiotics (J), consisting of 2 levels, namely: J1: types of sea fish, J2: types of fresh fish. The second factor is the dose of probiotics (P), consisting of 4 levels, namely: P1: dose of 1 ml of probiotics per 10 liters of water, P2: dose of 1.5 ml of probiotics per 10 liters of water, P3: dose of 2 ml of probiotics per 10 liters water, P4: dose of 2.5 ml of probiotics per 10 liters of water. The above treatment was repeated three times so that there were 24 experimental units. This study aims to obtain information about the exploration of local probiotics with the right dosage for nursery improvement and enlargement of sangkuriang catfish. The results showed that the utilization of probiotic types / sources originating from both fresh fish and sea fish turned out to have the same effect, but there was potential that the types / sources of probiotic fish produced higher absolute weight and absolute length. Probiotic doses have the same potential between low and high doses, but there is a tendency that 1.5 ml / 10 l water probiotic doses produce higher absolute length and absolute weight. There is no interaction between the types of probiotics and probiotic doses.
Keywords: waste, fish, probiotics, catfish, sangkuriang
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Telaumbanua, Betzy Victor, Putra Hidayat Telaumbanua, Natalia Kristiani Lase, and Januari Dawolo. "PENGGUNAAN PROBIOTIK EM4 PADA MEDIA BUDIDAYA IKAN: REVIEW." TRITON: Jurnal Manajemen Sumberdaya Perairan 19, no. 1 (April 13, 2023): 36–42. http://dx.doi.org/10.30598/tritonvol19issue1page36-42.
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Low feed quality in fish culture reduces fish digestibility; therefore, the feed quality needs improvement. An effort to increase the nutritional value of feed is by adding probiotics. However, on the one hand, feed residues that form organic and inorganic compounds can affect water quality in the cultivation medium; on the other hand, suitable water quality plays a vital role in fish farming. Adding probiotics containing microorganisms, such as EM4 probiotics, can benefit aquaculture businesses. Probiotic EM4 (Effective Microorganisms), one of the probiotics given in fish farming, is a brown liquid with a sweet and aromatic taste, containing a mixed culture of fermentative microorganisms, namely lactic acid bacteria (Lactobacillus casei) and yeast (Saccharomyces cerevisiae). This research is a literature review with data from various relevant articles assembled from Google Scholar, accredited journals, textbooks, and theses. In conclusion, it can be presumed that using EM4 probiotics in aquaculture has beneficial effects, including improving the quality of aquaculture water, increasing the growth rate of fish, suppressing pathogenicity, and reducing feed conversion.
ABSTRAK
Kualitas pakan yang rendah dalam akuakultur menyebabkan daya cerna ikan menjadi kurang optimal. Oleh karena itu, kualitas nutrisi pakan yang lebih baik perlu ditingkatkan. Upaya yang dapat dilakukan untuk meningkatkan nilai gizi pakan adalah dengan menambahkan probiotik. Namun di satu sisi, residu pakan yang membentuk senyawa organik dan anorganik dapat mempengaruhi kualitas air pada media budidaya; di sisi lain, kualitas air adalah salah satu faktor penting yang berperan dalam budidaya ikan. Penambahan probiotik yang mengandung mikroorganisme, seperti probiotik EM4, dapat menguntungkan usaha perikanan budidaya. Probiotik EM4 (Effective Microorganisms), salah satu probiotik yang diberikan dalam usaha budidaya ikan, merupakan cairan berwarna coklat dengan rasa manis dan aromatik, yang mengandung kultur campuran mikroorganisme fermentatif yaitu bakteri asam laktat (Lactobacillus casei) dan ragi (Saccharomyces cerevisiae). Penelitian ini merupakan literature review (kajian literatur) dengan data yang bersumber dari berbagai artikel relevan yang diperoleh dari google schoolar, jurnal terakreditasi, text book, skripsi, dan lain-lain. Berdasarkan hasil kajian, dapat dikatakan bahwa penggunaan probiotik EM4 dalam perikanan budidaya memberikan dampak menguntungkan, antara lain: memperbaiki kualitas air akuakultur, meningkatkan laju pertumbuhan ikan, menekan patogenitas, dan memperkecil konversi pakan.
Kata Kunci: Akuakultur, konversi pakan, laju pertumbuhan ikan, probiotik, probiotik EM4
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Tsaturyan, Vardan, Almagul Kushugulova, Susanna Mirzabekyan, Ketevan Sidamonidze, David Tsereteli, Tamas Torok, and Astghik Pepoyan. "Promising Indicators in Probiotic-recommendations in COVID-19 and its Accompanying Diseases." Open Access Macedonian Journal of Medical Sciences 10, B (January 17, 2022): 625–31. http://dx.doi.org/10.3889/oamjms.2022.7989.
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Scientific data suggests the possible beneficial role of probiotics in treatments for COVID-19, but the species/strains-specificity and disease-specificity of probiotics need high attention in choosing the appropriate probiotic in diseases, in particularly in the COVID-19. We hope this review will raise awareness of the COVID-19 probiotic recommendations, highlighting the latest scientific information about virus/hydrogen peroxide/probiotics and the importance of finding out of a specific “criterion” for the probiotics’ recommendation in this disease.
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H. L., Rowles. "Probiotics Slow the Growth of Pathogenic Bacteria." International Journal of Probiotics and Prebiotics 14, no. 1 (July 23, 2019): 28–31. http://dx.doi.org/10.37290/ijpp2641-7197.14:28-31.
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Probiotics are live microorganisms, which when ingested in sufficient amounts, confer health benefits to the host by improving the gut microflora balance. The purpose of this research was to determine whether commercial probiotic products containing multitude of commensal bacteria would reduce the growth rate of pathogenic bacteria, specifically Escherichia coli and Salmonella typhimurium. Growth curves were established, and the growth rates were compared for samples of E. coli, S. typhimurium, Nature’s Bounty Controlled Delivery probiotic, Sundown Naturals Probiotic Balance probiotic, and cocultures of the pathogenic bacteria mixed with the probiotics. The findings of this research were that the commercial probiotics significantly reduced the growth rate of E. coli and S. typhimurium when combined in cocultures. Probiotics containing multiple strains may be taken prophylactically to reduce the risk of bacterial infections caused by E. coli and S. typhimurium. Probiotics could be used to reduce the high global morbidity and mortality rates of diarrheal disease.
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Pech-Canul, Angel de la Cruz, David Ortega, Antonio García-Triana, Napoleón González-Silva, and Rosa Lidia Solis-Oviedo. "A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics." Coatings 10, no. 3 (February 25, 2020): 197. http://dx.doi.org/10.3390/coatings10030197.
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The consumption of probiotics has been associated with a wide range of health benefits for consumers. Products containing probiotics need to have effective delivery of the microorganisms for their consumption to translate into benefits to the consumer. In the last few years, the microencapsulation of probiotic microorganisms has gained interest as a method to improve the delivery of probiotics in the host as well as extending the shelf life of probiotic-containing products. The microencapsulation of probiotics presents several aspects to be considered, such as the type of probiotic microorganisms, the methods of encapsulation, and the coating materials. The aim of this review is to present an updated overview of the most recent and common coating materials used for the microencapsulation of probiotics, as well as the involved techniques and the results of research studies, providing a useful knowledge basis to identify challenges, opportunities, and future trends around coating materials involved in the probiotic microencapsulation.
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Zhang, Pei, Xiaoli Wu, Shan Liang, Xianfeng Shao, Qianqian Wang, Ruibing Chen, Weimin Zhu, Chen Shao, Feng Jin, and Chenxi Jia. "A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis." Science Signaling 13, no. 642 (July 28, 2020): eabb0443. http://dx.doi.org/10.1126/scisignal.abb0443.
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Certain probiotics have beneficial effects on the function of the central nervous system through modulation of the gut-brain axis. Here, we describe a dynamic landscape of the peptidome across multiple brain regions, modulated by oral administration of different probiotic species over various times. The spatiotemporal and strain-specific changes of the brain peptidome correlated with the composition of the gut microbiome. The hippocampus exhibited the most sensitive response to probiotic treatment. The administration of heat-killed probiotics altered the hippocampus peptidome but did not substantially change the gut microbiome. We developed a literature-mining algorithm to link the neuropeptides altered by probiotics with potential functional roles. We validated the probiotic-regulated role of corticotropin-releasing hormone by monitoring the hypothalamic-pituitary-adrenal axis, the prenatal stress–induced hyperactivity of which was attenuated by probiotics treatment. Our findings provide evidence for modulation of the brain peptidome by probiotics and provide a resource for further studies of the gut-brain axis and probiotic therapies.
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Arora, Malika, Navdeep Kaur, Parveen Bansal, and Ashish Baldi. "Therapeutic Potential of Probiotics: A Ray of Hope or Nightmare?" Applied Clinical Research, Clinical Trials and Regulatory Affairs 6, no. 1 (March 27, 2019): 18–33. http://dx.doi.org/10.2174/2213476x06666190126161931.
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Background:The role of various probiotic microorganisms with a particular emphasis on their therapeutic use in human health and disease has been highlighted by diverse scientific research reports. Due to improvement and introduction of new technologies useful to understand the functionality and mode of action of probiotics with respect to nutritional as well as health perspectives, the research on probiotics has recently grabbed the attention of manufacturers, regulators as well as researchers. Currently there are clinical trial based evidences to support the effectiveness of probiotic interventions in various types of diarrheal diseases, chronic gastrointestinal inflammatory disorders, hypercholesterolemia, hypertension, diabetes, oral health etc. However, due to inadequate awareness about risks associated with the probiotics amongst physicians, regulatory authorities, consumers and manufacturers many attributes like quality, safety and efficacy require urgent attention. At the same time regulatory guidelines for these products face ambiguity. So, it is of utmost importance to evaluate the true status of probiotic products available in market with respect to all above mentioned parameters and to formulate harmonized regulatory guidelines for the manufacturing of probiotic products.Conclusion:The present compilation aims to highlight the progression of probiotic research related to therapeutic potentials of probiotics, clinical trials on probiotics, risks and regulatory concerns associated with probiotics and their use.
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Fu, Songzhe, Qian Yang, Fenglan He, Ruiting Lan, Jingwei Hao, Ping Ni, Ying Liu, and Ruijun Li. "National Safety Survey of Animal-use Commercial Probiotics and Their Spillover Effects From Farm to Humans: An Emerging Threat to Public Health." Clinical Infectious Diseases 70, no. 11 (July 12, 2019): 2386–95. http://dx.doi.org/10.1093/cid/ciz642.
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Abstract Background Human-use probiotics have recently been associated with clinical infections and antibiotic resistance transfer, raising public concern over their safety. However, despite their extensive application in aquaculture and animal husbandry, the safety of animal-use probiotics remains poorly described. Methods We evaluated the safety of 92 animal-use probiotics from China. The pattern of spread of pathogens from probiotics and the consequent public health implications were also examined by conducting in-field genomic surveillance at 2 farms. Results A total of 123 probiotic Bacillus species isolates were obtained from 92 brands of probiotics, of which 45 isolates were resistant to antibiotics. Notably, 33.7% of probiotic products were contaminated with life-threatening pathogens such as Klebsiella pneumoniae. Genomic surveillance at a chicken farm identified an anthrax toxin–positive Bacillus cereus strain in a probiotic product used as a feed supplement, which was transferred into the groundwater and to a nearby fish farm. Following up retrospective analysis of the surveillance data during 2015–2018 in 3 provinces retrieved 2 B. cereus strains from human with intestinal anthrax symptoms and confirmed the transmission of B. cereus from farm to human. Surveillance of anthrax toxin revealed that cya was detected in 8 of 31 farms. Conclusions This study provides the first national safety survey of animal-use probiotics in China and confirms the spillover effects of probiotics from the farms to human. These results suggest that the large-scale application of pathogen-containing probiotics leads to the transfer of pathogens, with worrisome implications for public health. Good Manufacturing Practice should be implemented during the production of all probiotics. Animal-use probiotic products are frequently contaminated with viable pathogenic bacteria. This study revealed that virulent probiotic organisms and contaminating pathogens were colonized with farm animals and shed into the environment, which facilitated the transfer of pathogens to humans.
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Yao, Difei, Wei He, Yangmin Hu, Ying Yuan, Huimin Xu, Juan Wang, and Haibin Dai. "Prevalence and influencing factors of probiotic usage among colorectal cancer patients in China: A national database study." PLOS ONE 18, no. 9 (September 21, 2023): e0291864. http://dx.doi.org/10.1371/journal.pone.0291864.
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Probiotics have become increasingly popular among cancer patients. However, there is limited data from a real-world setting. This study aims to conduct a retrospective analysis to understand the trend of probiotic prescriptions in Chinese colorectal cancer patients. The Mann-Kendall and Cochran-Armitage trend test was applied to estimate the trend significance. Gephi software identified the combination of probiotic strains. The binary logistic regression investigated influence factors, and Spearman’s rank correlation coefficient calculated correlations between probiotics and antitumor drug usage. The probiotic prescription percentage increased from 3.3% in 2015 to 4.2% in 2021 (Z = 12.77, p < 0.001). Although 48.3% of probiotic prescriptions had no indication-related diagnosis, diarrhea (OR 10.91, 95% CI 10.57–11.26) and dyspepsia (3.97, 3.82–4.12) included prescriptions most likely to contain probiotics. Prescriptions from the tertiary hospital (1.43,1.36–1.50), clinics (1.30, 1.28–1.33), and senior patients (1.018 per year, 1.017–1.019) were more likely to contain probiotics. Most probiotic prescriptions (95.0%) contained one probiotic product but multiple strains (69.3%). Enterococcus faecalis (49.7%), Lactobacillus acidophilus (39.4%), and Clostridium butyricum (27.9%) were the most prescribed strains. The probiotics co-prescribed with antitumor agents increased rapidly from 6.6% to 13.8% in seven years (Z = 15.31, p < 0.001). Oral fluorouracil agents (2.35, 2.14–2.59), regorafenib (1.70,1.27–2.26), and irinotecan (1.27,1.15–1.41) had a higher probability to co-prescribed with probiotics. There was no correlation between probiotic strain selection and specific antitumor drug use. The increasing prescription of probiotics in colorectal cancer patients in China may be related to treating the gastrointestinal toxicity of anti-cancer drugs. With unapproved indications and a lack of strain selectivity, evidence-based guidelines are urgently needed to improve probiotic use in this population.
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Dou, Jiaxin, Ning Feng, Fangyu Guo, Zouquan Chen, Jie Liang, Ting Wang, Xueping Guo, and Zhenshang Xu. "Applications of Probiotic Constituents in Cosmetics." Molecules 28, no. 19 (September 22, 2023): 6765. http://dx.doi.org/10.3390/molecules28196765.
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Over the past few decades, research on the benefits of beneficial microorganisms on skin health has expanded and attracted a lot of attention. Today, a wide range of probiotic products are becoming available. With their extensive component profiles and varied physiological effects, probiotics, as well as extracts of them, have a significant impact on cosmetics. However, the present boom in consumer interest in alternatives has broadened the probiotic industry’s research and development frontiers. Considering the foregoing, it should come as no surprise that probiotics are highly valued for their proven anti-aging, skin whitening, anti-inflammatory, and photoprotective effects. This review aims to compile information on probiotics’ properties, their extracts, and preparations used in cosmetics. It also further summarizes research and applications on probiotic fermentation to promote the use of probiotic fermentation products in cosmetics. Notably, this review also adds information on particular properties and mechanisms of action of probiotics, which fills a gap in the research and application of probiotics in skin treatment and care. Their antioxidant and anti-aging qualities have received particular consideration. This review provides a new basis for the broad application of probiotics in cosmetics.
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Aslamyah, Siti. "KUALITAS LINGKUNGAN DAN AKTIVITAS ENZIM PENCERNAAN UDANG VANNAMEI (Litopenaeus vannamei) PADA BERBAGAI KONSENTRASI PROBIOTIK BIOREMEDIASI-Bacillus sp. (THE ENVIRONMENTAL QUALITY AND ENZYME ACTIVITIES OF DIGESTIVE VANNAMEI SHRIMP (Litopenaeus vannamei) ON VARIOUS CONCENTRATIONS OF BIOREMEDIATION-Bacillus sp. PROBIOTICS)." Fish Scientiae 1, no. 2 (June 17, 2016): 161. http://dx.doi.org/10.20527/fs.v1i2.1186.
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Probiotik Bioremediasi-Bacillus sp. dengan komposisi bakteri yang menguntungkan, serta bekerja secara sinergis pada lingkungan budidaya dan pada saluran cerna inang. Selain, dapat memperbaiki kualitas lingkungan juga dapat meningkatkan aktivitas enzim pencernaan udang. Pada akhirnya menyebabkan peningkatan pertumbuhan dan memperkecil resiko timbulnya penyakit pada udang. Tujuan dari penelitian ini menentukan konsentrasi optimum aplikasi probiotik Bioremediasi-Bacillus sp. dalam media budidaya udang vannamei. Penelitian didesain dalam Rancangan Acak Lengkap (RAL) dengan 4 perlakuan konsentrasi probiotik Bioremediasi-Bacillus sp. yaitu kontrol (tanpa probiotik); 0,5; 1,0; 1,5 ppm per minggu, masing-masing dengan 3 ulangan. Selama penelitian, udang uji dipelihara dalam akuarium kaca berkapasitas 30 L dengan kepadatan 4 ekor/L dan diberi pakan berbentuk powder dengan kadar protein 52% sebanyak 70-100% total biomassa. Media air yang digunakan bersalinitas ± 30 ppt sebanyak 25 L. Hasil penelitian menunjukkan terjadi perbaikan kualitas lingkungan budidaya pada perlakuan aplikasi probiotik, terutama kadar amoniak lebih rendah dibandingkan kontrol. Kadar enzim pencernaan α-amilase dan protease juga meningkat signifikan dibandingkan kontrol. Keadaan inilah yang menyebabkan sintasan dan pertumbuhan udang vannamei yang mendapat perlakuan pemberian probiotik lebih tinggi dibandingkan kontrol, sedangkan berbagai konsentrasi probiotik tidak menghasilkan respon perbedaan. Dapat disimpulkan aplikasi probiotik Bioremediasi-Bacillus sp. dengan konsentrasi 0,5 ppm per minggu dalam media budidaya dapat memperbaiki kualitas lingkungan budidaya dan aktivitas enzim pencernaan α-amilase dan protease, sehingga dapat meningkatkan sintasan dan pertumbuhan udang vannamei.Bioremediation-Bacillus sp. probiotics with the composition of the beneficial bacteria, as well as working synergistically on aquaculture and environment in the host gastrointestinal tract. In addition, it can improve the quality of the environment can also increase the activity of digestive enzymes shrimp. Ultimately lead to increased growth and minimize the risk of disease of shrimp. The purpose of this study to determine the optimum concentration of applications Bioremediation-Bacillus sp. probiotics vannamei shrimp culture in the media. The study was designed in a Completely Randomized Design (CRD) with 4 treatment concentration of bioremediation-Bacillus sp. probiotics the control (without probiotic), 0.5; 1.0, 1.5 ppm per week, with three replications each. During the study, the test shrimp rearing in glass aquaria with a capacity of 30 L with a density of 4 fish / L and fed the form of powder with 52% protein content as much as 70-100% of total biomass. Water medium used ± 30 ppt salinity as much as 25 L. The results showed improvement of environmental quality cultivation occurs in the probiotic treatment applications, particularly ammonia levels lower than controls. Digestive enzyme levels of α-amylase and protease also increased significantly compared to controls. This condition which cause the vannamei shrimp survival and growth were receiving higher than controls of probiotic treatment, while various concentrations of probiotic did not produce differences in response. Application of Bioremediation-Bacillus sp. probiotics can be concluded with a concentration of 0.5 ppm per week in culture media can improve the quality of the environment cultivation and the activity of digestive enzymes α-amylase and protease, thus increasing the survival and growth of vannamei shrimp
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Kolady, Deepthi, Kendra Kattelmann, Caleb Vukovich, and Joy Scaria. "Awareness and use of probiotics among the millennials in the United States: Drivers and implications." Functional Foods in Health and Disease 8, no. 10 (October 31, 2018): 495. http://dx.doi.org/10.31989/ffhd.v8i10.536.
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Background: Despite the substantial increase in the number of probiotic products available in the U.S. during the last decade and the potential for millennials to be a large market for probiotics, there is a lack of understanding about millennials’ awareness, use, and preference for probiotics. In this study, we examine the relationship between the millennials’ health and diet perceptions and health outcomes, estimate awareness and use levels of probiotics among the millennials, and identify the drivers of use of probiotics.Methods: An online opt-in Internet panel is used to collect national level survey data on awareness, and use of probiotics from the U.S. population in the age group of 21 to 37 years old.Results: The study finds that there is divergence in millennials’ perceptions about their health and diet and health outcomes; awareness about probiotics is high and probiotics use is common among the millennials; demographic, socio-economic, and life style related attributes are influential in millennials’ decision on the use of probiotics;, and shakes and yogurt are the most preferred carrier forms of probiotics among the millennials. The study also finds that income constraints and perception of good health status are the major factors hindering the use of probiotics among the millennials.Conclusion: The study shows that millennials are already an important market for probiotics and there is substantial scope for expanding that market. The ability of probiotics to address public health concerns will depend greatly on how health care providers and probiotic industry will leverage these high levels of awareness and use by the millennials. Findings from our study provide insights that are helpful for probiotics product and market development and outreach efforts that will result in increased use of probiotics among the millennials with positive implications for public health and overall economy.Keywords: consumer preference, probiotic industry, health policy, shakes, yogurt
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Chilmawati, Diana, Fronthea Swastawati, Ima Wijayanti, Ambaryanto Ambaryanto, and Bambang Cahyono. "PENGGUNAAN PROBIOTIK GUNA PENINGKATAN PERTUMBUHAN, EFISIENSI PAKAN, TINGKAT KELULUSHIDUPAN DAN NILAI NUTRISI IKAN BANDENG (Chanos chanos) (Probiotic Use for Growth Improvement, Feed Efficiency, Survival Rate and Nutrition Value of Milkfish (Chanos chanos))." SAINTEK PERIKANAN : Indonesian Journal of Fisheries Science and Technology 13, no. 2 (February 15, 2018): 119. http://dx.doi.org/10.14710/ijfst.13.2.119-125.
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Budidaya bandeng sebagai bahan baku berbagai olahan perlu didukung dengan teknologi yang intensif. Peningkatan kualitas nutrisi bandeng diperlukan untuk memperoleh bahan baku yang tidak hanya banyak tetapi juga bernutrisi. Penambahan probiotik ke dalam pakan bandeng dapat meningkatkan efisiensi pakan agar pakan lebih mudah dicerna dan enzim dapat bekerja lebih efektif. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan probiotik terhadap pertumbuhan, efisiensi pakan, tingkat kelulushidupan dan nilai nutrisi ikan bandeng. Bahan yang digunakan adalah ikan bandeng dengan berat rata-rata 102±2,58 g, pakan bandeng komersil dengan kandungan protein 30% dan probiotik dengan komposisi jamur Saccharomyces cerevisiae, Aspergillus oryzae, bakteri Lactobacillus acidophilus, Bacillus subtilis, Rhodopseudomonas, Actinomycetes dan Nitrobacter. Penelitian dilakukan menggunakan metode eksperimental dengan Rancangan Acak Kelompok dengan dua perlakuan dan 5 kali ulangan. Analisis data menggunakan uji t untuk membandingkan budidaya ikan bandeng perlakuan A yaitu tanpa penggunaan probiotik dalam pakan dan perlakuan B yaitu dengan penggunaan probiotik dalam pakan. Hasil uji t menunjukkan penggunaan probiotik pada pakan berpengaruh nyata (P<0,05) pada pertumbuhan, efisiensi pakan dan nilai nutrisi namun tidak berpengaruh nyata (P>0,05) pada tingkat kelulushidupan ikan bandeng. Penggunaan probiotik pada pakan bandeng memberikan nilai RGR (1.958±0.02%/hari), nilai EPP (78.333±0.745%), kandungan protein (25.794±0.600%) lebih tinggi dan FCR (1.321±0.030) yang lebih baik dari perlakuan tanpa penggunaan probiotik dalam pakan bandeng. Milkfish culture as main raw materia for various processed food needs intensive technology support. Improvement in milkfish nutrition quality is necessary to obtain many raw nutritious materials.The addition of probiotics to milkfish feed is able to improve feed efficiency. Thus, the feed is easier to digest and the enzymes can work more effectively. This study aims to find out the effect of probiotic use on the growth, feed efficiency, survival rate and nutritional value of milkfish. The materials used in thi study were milkfish with an average weight of 102 ± 2.58 g, commercial milkfish feed with 30% protein content and probiotics composed of fungus Saccharomyces cerevisiae, Aspergillus oryzae, Lactobacillus acidophilus, Bacillus subtilis, Rhodopseudomonas, Actinomycetes and Nitrobacter. The study was conducted using an experimental method with a randomized block design with two treatments and 5 repetitions. Data analysis was conducted using T test to compare milkfish culture treatment A,i.e. without the use of probiotics in feed and treatment B by using probiotics in feed. The results of the t test showed that the use of probiotics in feed had a significant effect (P <0.05) on growth, feed efficiency and nutritional value but had no significant effect (P> 0.05) on the level of milkfish survival capability. The use of probiotics in milkfish feed resulted in RGR value (1.958 ± 0.02% / day), EPP value (78.333 ± 0.745%),higher protein content (25.794 ± 0.600%) and FCR (1.321 ± 0.030) which was better than the treatment without the us of probiotics in milkfish feed.
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Demir, Ebru, Gülden Başyiğit Kılıç, and Demircan Özbalcı. "Probiyotiklerin Biyogüvenilirlik Özellikleri “Probiyotikler”." Turkish Journal of Agriculture - Food Science and Technology 7, no. 4 (April 23, 2019): 639. http://dx.doi.org/10.24925/turjaf.v7i4.639-645.2327.
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Probiotics are defined as live microorganisms that provide many health benefits when consumed in sufficient quantities. Lactic acid bacteria (LAB) are found in the natural flora of foods such as milk, meat, fruits and vegetables and are used as culture in the production of fermented foods. These bacteria are also found in the microbiota of the intestines, mouth, skin, urinary systems, both humans and animals and may have a beneficial influence on these ecosystems. Some Lactobacillus species, Bifidobacterium spp., Saccharomyces boulardii, and some other microorganisms have been used as probiotic as food supplement in order to benefit health. Even though probiotics have been proven to have beneficial effects for the majority of patients on treatment, the existence of risks for the immunosuppressed patients has been also reported. There are more evidence that the use of probiotics in patients with organ failure, immuno-compromised status and dysfunctional gut barrier can cause infections. Before considering to use probiotics as a treatment option, it should be totally proven that probiotics have no harmful effect on human. First of all, it is important that classical biochemical tests are completed in a competent laboratory by molecular methods in identification of LAB to be used as a probiotic. Several approaches are possible in the assessment of the probiotic safety; studies on the intrinsic properties, the pharmacokinetics of the probiotic strain and the interactions between the probiotic strain and the host. There are no required standards for safety and protocols for usage of probiotics. More information is needed whether the probiotics can be used for the treatment or prevention of disease. The use of probiotics should also be comprehensively updated to determine their probable negative effects.
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Bezek, Katja, Emina Fajković, and Mojca Stubelj. "Parents’ perspective on probiotics in preschool children: A cross-sectional survey." Slovenian Journal of Public Health 62, no. 1 (December 28, 2022): 5–12. http://dx.doi.org/10.2478/sjph-2023-0002.
Full textAbstract:
Abstract Introduction The composition of the human gut microbiota, which can also be regulated by the consumption of probiotics, has a significant impact on host health. The main source of probiotics can be foods such as fermented foods, yogurts, fermented drinks and/or probiotic supplements. While parents play a critical role in ensuring the well-being of their children, this cross-sectional study is focused on parents’ perspectives regarding the use of probiotics in the preschool period. Methods The self-administered online survey consisted of 24 questions arranged across two thematic sections. The final data analysis included 102 parents (96% F; 4% M), aged between 22 and 47. Their children were aged up to 6 years. Results The majority (52%) of the parents were familiar with the term ‘probiotics’ and 86.3% were including probiotics in their children’s diet at the time of the survey. The main source was probiotic food (36.3%), of which yoghurt was the most commonly consumed (87.2%). The inclusion of probiotic supplements in a child’s diet was positively correlated with parents’ consumption and level of knowledge about the term ‘probiotics’. Digestive tract-related disorders were the most frequently reported motive for the initial introduction of probiotics into children’s diet. Conclusions Based on our study results, parents are familiar with probiotics and include them in their children’s diet. However, an attempt should be made to close the gaps in parents’ knowledge that our research identified. Further studies are needed to determine the recommended amount of probiotic foods, as well as strategies to educate parents about the benefits of including probiotic foods in their children’s diet.