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Academic literature on the topic 'PRIORITIZE GENES'

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Published: 11 September 2023

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Journal articles on the topic "PRIORITIZE GENES"

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Gong, Lejun, Ronggen Yang, Chun Zhang, Quan Liu, Huakang Lee, and Geng Yang. "RE-RANKING FOR PRIORITIZATION OF DISEASE-RELATED GENES." Biomedical Engineering: Applications, Basis and Communications 28, no. 04 (August 2016): 1650027. http://dx.doi.org/10.4015/s1016237216500277.

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To explore the genetic complexity of disease, this paper focuses on the prioritization of susceptibility genes by re-ranking. This approach prioritizes disease-related genes based on the prior ranking. The genes in prior ranking are divided into seeds and candidates. And then these seed genes are used to prioritize candidates based on association rules. Experimental results show the approach is promising for finding new disease-related genes.
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Zhang, Yi, Tao Wang, Yan Wang, Kun Xia, Jinchen Li, and Zhongsheng Sun. "Targeted sequencing and integrative analysis to prioritize candidate genes in neurodevelopmental disorders." Molecular Neurobiology 58, no. 8 (April 15, 2021): 3863–73. http://dx.doi.org/10.1007/s12035-021-02377-y.

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AbstractNeurodevelopmental disorders (NDDs) are a group of diseases characterized by high heterogeneity and frequently co-occurring symptoms. The mutational spectrum in patients with NDDs is largely incomplete. Here, we sequenced 547 genes from 1102 patients with NDDs and validated 1271 potential functional variants, including 108 de novo variants (DNVs) in 78 autosomal genes and seven inherited hemizygous variants in six X chromosomal genes. Notably, 36 of these 78 genes are the first to be reported in Chinese patients with NDDs. By integrating our genetic data with public data, we prioritized 212 NDD candidate genes with FDR < 0.1, including 17 novel genes. The novel candidate genes interacted or were co-expressed with known candidate genes, forming a functional network involved in known pathways. We highlighted MSL2, which carried two de novo protein-truncating variants (p.L192Vfs*3 and p.S486Ifs*11) and was frequently connected with known candidate genes. This study provides the mutational spectrum of NDDs in China and prioritizes 212 NDD candidate genes for further functional validation and genetic counseling.
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Xin, Huang, Wang Changchen, Liu Lei, Yang Meirong, Zhang Ye, and Pan Bo. "The Phenolyzer Suite: Prioritizing the Candidate Genes Involved in Microtia." Annals of Otology, Rhinology & Laryngology 128, no. 6 (April 2, 2019): 556–62. http://dx.doi.org/10.1177/0003489419840052.

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Objective: Microtia is a congenital malformation of the external ear. Great progress about the genetic of microtia has been made in recent years. This article was to prioritize the potential candidate pathogenic genes of microtia based on existing studies and reports, with the purpose of narrowing the range of following study scientifically and quickly. Method: A computational tool called Phenolyzer (phenotype-based gene analyzer) was used to prioritize microtia genes. Microtia, as a query term, was input in the interface of Phenolyzer. After several steps, including disease match, gene query, gene score system, seed gene growth, and gene ranking, the final results about genetic information of microtia were provided. Then we tracked details of the top 10 genes ranked by Phenolyzer on the basis of previous reports. Results: We detected 10 348 genes associated with microtia or related syndromes, and 78 genes of those genes belonged to seed genes. Every gene was given a score, and the gene with higher scores was more likely influence microtia. The top 10 ranked genes included HOXA2, CHD7, CDT1, ORC1, ORC4, ORC6, CDC6, MED12, TWIST1, and GLI3. Otherwise, four gene-gene interactions were displayed. Conclusion: This article prioritized candidate genes of microtia for the first time. High-throughput methods provide tens of thousands of single-nucleotide variants, indels, and structural variants, and only a handful are relevant to microtia or associated syndromes. Combine the ranked potential pathogenic genes list from Phenolyzer with the results of samples provided by high-throughput methods, and more precise research directions are presented.
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Tranchevent, L. C., F. B. Capdevila, D. Nitsch, B. De Moor, P. De Causmaecker, and Y. Moreau. "A guide to web tools to prioritize candidate genes." Briefings in Bioinformatics 12, no. 1 (March 21, 2010): 22–32. http://dx.doi.org/10.1093/bib/bbq007.

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Rylander, Ragnar. "Genes and Agents: How to Prioritize to Prevent Disease." Archives of Environmental Health: An International Journal 50, no. 5 (October 1995): 333–34. http://dx.doi.org/10.1080/00039896.1995.9935963.

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Asefa, Nigus G., Zoha Kamali, Satyajit Pereira, Ahmad Vaez, Nomdo Jansonius, Arthur A. Bergen, and Harold Snieder. "Bioinformatic Prioritization and Functional Annotation of GWAS-Based Candidate Genes for Primary Open-Angle Glaucoma." Genes 13, no. 6 (June 13, 2022): 1055. http://dx.doi.org/10.3390/genes13061055.

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Background: Primary open-angle glaucoma (POAG) is the most prevalent glaucoma subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most likely ‘causal’ genes and identify functional characteristics and underlying biological pathways of POAG candidate genes. Methods: We used the results of a large POAG genome-wide association analysis study from GERA and UK Biobank cohorts. First, we performed systematic gene-prioritization analyses based on: (i) nearest genes; (ii) nonsynonymous single-nucleotide polymorphisms; (iii) co-regulation analysis; (iv) transcriptome-wide association studies; and (v) epigenomic data. Next, we performed functional enrichment analyses to find overrepresented functional pathways and tissues. Results: We identified 142 prioritized genes, of which 64 were novel for POAG. BICC1, AFAP1, and ABCA1 were the most highly prioritized genes based on four or more lines of evidence. The most significant pathways were related to extracellular matrix turnover, transforming growth factor-β, blood vessel development, and retinoic acid receptor signaling. Ocular tissues such as sclera and trabecular meshwork showed enrichment in prioritized gene expression (>1.5 fold). We found pleiotropy of POAG with intraocular pressure and optic-disc parameters, as well as genetic correlation with hypertension and diabetes-related eye disease. Conclusions: Our findings contribute to a better understanding of the molecular mechanisms underlying glaucoma pathogenesis and have prioritized many novel candidate genes for functional follow-up studies.
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Cabrera-Andrade, Alejandro, Andrés López-Cortés, Gabriela Jaramillo-Koupermann, César Paz-y-Miño, Yunierkis Pérez-Castillo, Cristian R. Munteanu, Humbert González-Díaz, Alejandro Pazos, and Eduardo Tejera. "Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis." International Journal of Molecular Sciences 21, no. 3 (February 5, 2020): 1053. http://dx.doi.org/10.3390/ijms21031053.

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Osteosarcoma is the most common subtype of primary bone cancer, affecting mostly adolescents. In recent years, several studies have focused on elucidating the molecular mechanisms of this sarcoma; however, its molecular etiology has still not been determined with precision. Therefore, we applied a consensus strategy with the use of several bioinformatics tools to prioritize genes involved in its pathogenesis. Subsequently, we assessed the physical interactions of the previously selected genes and applied a communality analysis to this protein–protein interaction network. The consensus strategy prioritized a total list of 553 genes. Our enrichment analysis validates several studies that describe the signaling pathways PI3K/AKT and MAPK/ERK as pathogenic. The gene ontology described TP53 as a principal signal transducer that chiefly mediates processes associated with cell cycle and DNA damage response It is interesting to note that the communality analysis clusters several members involved in metastasis events, such as MMP2 and MMP9, and genes associated with DNA repair complexes, like ATM, ATR, CHEK1, and RAD51. In this study, we have identified well-known pathogenic genes for osteosarcoma and prioritized genes that need to be further explored.
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Somepalli, Gowthami, Sarthak Sahoo, Arashdeep Singh, and Sridhar Hannenhalli. "Prioritizing and characterizing functionally relevant genes across human tissues." PLOS Computational Biology 17, no. 7 (July 16, 2021): e1009194. http://dx.doi.org/10.1371/journal.pcbi.1009194.

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Knowledge of genes that are critical to a tissue’s function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model–FUGUE–combining transcriptional and network features, to predict tissue-relevant genes across 30 human tissues. FUGUE achieves an average cross-validation auROC of 0.86 and auPRC of 0.50 (expected 0.09). In independent datasets, FUGUE accurately distinguishes tissue or cell type-specific genes, significantly outperforming the conventional metric based on tissue-specific expression alone. Comparison of tissue-relevant transcription factors across tissue recapitulate their developmental relationships. Interestingly, the tissue-relevant genes cluster on the genome within topologically associated domains and furthermore, are highly enriched for differentially expressed genes in the corresponding cancer type. We provide the prioritized gene lists in 30 human tissues and an open-source software to prioritize genes in a novel context given multi-sample transcriptomic data.
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Mahmood, Iqra, Asif Nadeem, Masroor Ellahi Babar, Muhammad Muddassir Ali, Maryam Javed, Aisha Siddiqa, Tanveer Hussain, and Muhammad Tariq Pervez. "Systematic and Integrated Analysis Approach to Prioritize Mastitis Resistant Genes." Pakistan Journal of Zoology 49, no. 1 (2016): 101–6. http://dx.doi.org/10.17582/journal.pjz/2017.49.1.101.106.

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Oliver, Karen L., Vesna Lukic, Natalie P. Thorne, Samuel F. Berkovic, Ingrid E. Scheffer, and Melanie Bahlo. "Harnessing Gene Expression Networks to Prioritize Candidate Epileptic Encephalopathy Genes." PLoS ONE 9, no. 7 (July 9, 2014): e102079. http://dx.doi.org/10.1371/journal.pone.0102079.

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Dissertations / Theses on the topic "PRIORITIZE GENES"

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Alcon, Timothy C. "Using a seed-network to query multiple large-scale gene expression datasets from the developing retina in order to identify and prioritize experimental targets." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1473175.

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CHAHAL, ASHISH. "ANALYSIS AND ANNOTATION OF EXOME SEQUENCING DATA TO IDENTIFY AND PRIORITIZE GENES RESPONSIBLE FOR PROSTATE ADENOCARCINOMA." Thesis, 2015. http://dspace.dtu.ac.in:8080/jspui/handle/repository/15573.

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After skin cancer prostate cancer is the second most prevalent cancer in men. Somatic mutations in Prostate Adenocarcinoma are revealed by processing of the next-generation DNA sequencing data of the exome region. Mutation in exome region directly effects the expression of the genes and sometimes inhibits the expression which can lead to several diseases. High throughput technologies and NGS analysis enable us to find out variations in the exome region that are involved in complex pathways of cancers. Biomarkers can be identified using NGS and exome sequencing analysis pipelines which can help in diagnosis, treatment and prognosis of the cancer. Exome play a major role in protein profiling so any change in this region affect the individual. PRAD exome data was used to analyze the variations in the exome region. Data for PRAD was downloaded from the TCGA web portal for tumor matched with normal types 17 samples on which exome sequence analysis pipeline were applied to predict and prioritize the genes involved for PRAD pathway. Perl programming language was used to prioritize and analyze the exome data. Perl script maf2vcf.pl, DisGeNET, Annovar software packages were used to find out 93 probable genes that were filtered from DisGeNET. Then 54 genes were found in conserved regions with phastconselements46way score > 400. 17 TCGA IDs samples showed sequence alignment errors which were filtered by matching with segmented duplications. Polyphen2 annotations were used to give scores about the deleterious effect of the variants. After these steps we got the most probable genes that might be responsible for the cause of Prostate Adenocarcinoma (PRAD). GSTT1, TP53, CYP19A1, BRAF genes were already involved in the pathway of occurrence of prostate cancer and these genes were also present in the filtered genes in this study. Using experimental validation methods on the filtered genes we may help in finding out the novel genes that are involved in the complex pathway of prostate cancer.
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Lin, Shu-Ju, and 林書如. "Use of Pathway Score in Bayesian Model to Quantify and Prioritize Pathway Association and Gene Ranking." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/yx3fab.

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博士
國立臺灣大學
流行病學與預防醫學研究所
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Cancer is an important topic of global concern. Some cancers are closely related to genetic aberrations. Not only is there a large number of new cancer patients per year, but the number of deaths due to cancer is also high. Genetic testing can help understand one’s disease risk and may prevent disease occurrence, if the causal key genes can be identified. Therefore, many researchers focus on identifying the key genes, among more than 20,000 human genes. Researchers need a lot of time and money to find key genes. In order to reduce costs, providing a prioritized list may help to find key genes. Currently, methods for screening genes associated with diseases are roughly classified into three types, such as the single marker tests, gene-set analysis methods, and pathway analysis, to provide candidate genes or candidate gene sets. Some statistical methods find disease-related genes from a single marker test, such as the T test or Chi-square test. However, due to the large number of biomarkers, scientists need to face the issue of multiple testing. Single marker test did not consider the relationship between genes. Genes do not work alone and need to work with other genes to affect a biological process. Therefore, rather than focusing on the effect of a single gene on biological processes, the effect of a group of genes should be considered. So there is a second type of method to find disease-related genes in a group of genes, such as the Gene Set Enrichment Analysis (GSEA), Over Representation Analysis (ORA), Globa test, and Fisher''s method. A pathway is a collection of genes containing biological meaning. The pathway represents a biological process carried out by a group of genes. The third method uses pathways to find related genes, such as Signaling Pathway Impact Analysis (SPIA). Currently, such methods do not consider simultaneously several competing pathways; they do not incorporate the relationship between pathways, nor account for the relationship between genes. This study will provide a novel method to overcome the limitations of current methods. This study not only considers the relationship between genes in the pathway but also considers the competition between several pathways and the relationship between pathways. Bayesian Approach to Prioritizing Pathway (BAPP), a novel method proposed under the above conditions, provides a list of ordered candidate pathways associated with the disease. The BAPP can further search for key genes in the primary pathway, and provide disease-related key genes. BAPP can be applied on the common pathway database, Kyoto Encyclopedia of Genes and Genomes (KEGG). Simulations show that BAPP performs well. Whether it is prioritizing candidate pathways or key genes, BAPP can control the type I error rate under 0.05. BAPP correctly ranks candidate pathways at a higher accuracy than other methods and can find true key genes. This novel method is applied to a breast cancer study and a glioblastoma multiforme study. In breast cancer data, BAPP identifies the primary pathway of breast cancer as the Jak-STAT signaling pathway, and further identifies 37 key genes in this pathway. The Taste transduction pathway that has not been reported to associate with breast cancer is ranked last by BAPP. In the glioblastoma multiforme study, BAPP identifies Long-term potentiation as the primary pathway, and from which four key genes are identified.
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Books on the topic "PRIORITIZE GENES"

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Schutte, Nienke M., Meike Bartels, and Eco JC de Geus. Genetics of physical activity and physical fitness. Edited by Neil Armstrong and Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0020.

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Regular physical activity and fitness are key contributors to children’s health. It is important to understand sources of variation in phenotypes seen among children and adolescents. It is important to calculate the relative importance of genetic and environmental factors to observed individual differences. Heritability estimates of physical activity vary, depending on sample size and measurement instrument, but the overall importance of environmental factors seems to decrease in adolescence, whereas genetic effects become more prominent. Twin and family studies show that individual differences in maximal oxygen uptake, muscle strength, flexibility, and balance are affected by genetic factors. Some evidence is found for specific genes coding for physical activity and fitness, but children and adolescent studies are limited. Future research should prioritize these target groups as knowledge of the source of individual differences in physical activity and fitness at different time points can optimize the choice and timing of exercise intervention.
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Raykoff, Ivan. Liberace’s Musical/Material Appeal. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780199935321.013.175.

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Inspired by the celebrated pianist-bandleaders Eddy Duchin and Carmen Cavallaro and the cinematic technique of José Iturbi in Hollywood films, pianist-entertainer Liberace (1919–1987) developed a distinctive and highly successful aesthetic and performance style that prioritized visual spectacle and emphasized the tactile elements of his playing. As evident in his first Soundies from 1943, then his nationally syndicated television show in the 1950s, Liberace highlighted the physicality and materiality of his music-making, an approach that later evolved into the signature props and flashy costumes of his live stage shows. The new medium of television enabled Liberace to integrate the traditions of Romantic pianism with new genres of popular music in a highly embodied manner that appealed to his fans as much as it bothered his critics invested in music’s physical and material transcendence.
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Miller, Timothy. This Machine Plays Country Music. Edited by Travis D. Stimeling. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190248178.013.27.

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This chapter explores the origins and development of the pedal steel guitar, showing the evolution of instrument traditions as an undercurrent to histories of genre and style. The pedal steel’s emergence in the early 1950s was a continuation of developments from the previous decades, as the exploration of technological answers to the musical “problems” of the steel guitar led to an expanded palette of sounds and gestures. The development of the instrument’s technology and vocabulary occurred within a community of musicians and makers whose priorities both reinforced and challenged the aesthetic values of country music. This history is illustrated through transcriptions and analyses of recordings by key innovators of the 1950s–1970s. The chapter concludes by discussing different trajectories of the pedal steel in the twenty-first century, where it remains a crucial part of country music but has also found a place in other genres and styles.
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Book chapters on the topic "PRIORITIZE GENES"

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Nicolás, Marisa Fabiana, Maiana de Oliveira Cerqueira e Costa, Pablo Ivan P. Ramos, Marcelo Trindade dos Santos, Ernesto Perez-Rueda, Marcelo A. Marti, Dario Fernandez Do Porto, and Adrian G. Turjanski. "Integrating Omics Data to Prioritize Target Genes in Pathogenic Bacteria." In Networks in Systems Biology, 217–76. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51862-2_10.

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Demneh, Sayedeh Razieh Abdollahi, Sama Goliaei, and Zahra Razaghi Moghadam. "Associating Protein Interactions with Disease Comorbidity to Prioritize Colorectal Cancer Genes." In International Conference on Biomedical and Health Informatics, 91–95. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-4505-9_15.

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Kaimal, Vivek, Divya Sardana, Eric E. Bardes, Ranga Chandra Gudivada, Jing Chen, and Anil G. Jegga. "Integrative Systems Biology Approaches to Identify and Prioritize Disease and Drug Candidate Genes." In Methods in Molecular Biology, 241–59. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-954-3_16.

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Milano, Marianna. "Using Gene Ontology to Annotate and Prioritize Microarray Data." In Methods in Molecular Biology, 273–87. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1839-4_18.

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Marshall, John M., and Ace R. North. "Modeling Priorities as Gene Drive Mosquito Projects Transition from Lab to Field." In Mosquito Gene Drives and the Malaria Eradication Agenda, 197–237. New York: Jenny Stanford Publishing, 2023. http://dx.doi.org/10.1201/9781003308775-10.

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Raychaudhuri, Soumya. "Text-Based Analysis of a Single Series of Gene Expression Measurements." In Computational Text Analysis. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780198567400.003.0012.

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In this chapter we begin to address the issue of the analysis of gene expression data with the scientific literature. Here we describe methods for the analysis of a single experiment—one where a single expression measurement has been made for many genes within the same organism. In Chapter 7 we will address the analysis of larger data sets with multiple expression measurements for each of the genes; the questions that occur in that setting are often more complex and utilization of scientific text in that setting can be more useful. But focusing on a single series of expression measurements is an effective starting point in understanding the scientific literature and how it can be used with experimental data. The lessons here can be applied to a wide array of genomic assays besides gene arrays. These methods can be applied to any assay that assigns a single value to each gene In addition, many investigators generate single-condition expression data sets, and these methods are widely applicable. One of the great difficulties in analyzing a single expression series is that context is lacking. That is, we have a large set of isolated measurements. Each measurement corresponds to the log of the relative ratio of a single gene’s expression in an experimental condition compared to its expression in a control condition. These measurements represent a single snapshot of a cell’s physiologic status. One of the great challenges is sorting out the physiologically important expression changes compared to random experimental and physiologic aberrations and fluctuations. Gene expression measurements are subject to a great amount of noise and distinguishing true positives from genes that are not truly induced or repressed is a great challenge. Typically, investigators use their knowledge of biology to prioritize likely positives. In this chapter we argue that text-mining approaches can be used to help prioritize these genes instead. Another equally important challenge is to discern broadly what biological functions are active in a given experiment.
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Hu, Hong, and Yang Dai. "Prioritize Transcription Factor Binding Sites for Multiple Co-Expressed Gene Sets Based on Lasso Multinomial Regression Models." In Biotechnology, 940–68. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-8903-7.ch037.

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Computational prediction of cis-regulatory elements for a set of co-expressed genes based on sequence analysis provides an overwhelming volume of potential transcription factor binding sites. It presents a challenge to prioritize a set of functional transcription factors and their binding sites on the regulatory regions of the target genes that are relevant to the gene expression study. A novel approach based on the use of lasso multinomial regression models is proposed to address this problem. We examine the ability of the lasso models using a time-course microarray data obtained from a comprehensive study of gene expression profiles in skin and mucosal in mouse over all stages of wound healing.
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Loreta Paun, Diana, and Alexandra Mirica. "Pheochromocytomas and Paragangliomas: Genotype-Phenotype Correlations." In Pheochromocytoma, Paraganglioma and Neuroblastoma. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95888.

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Pheochromocytomas and paragangliomas are rare neuroendocrine tumors, with genetic background in about 40% of cases, involving more than 30 susceptibility genes. The susceptibility genes can be divided into three main molecular clusters: pseudohypoxic, kinase signaling, and Wnt signaling. Biochemical characterization of these particular tumors should be integrated into the diagnostic algorithm because it can help apply personalized medicine principles and targeted therapy. These tumors can present with very different genotype-phenotype correlations, and their characterization can help the clinical practitioner make optimal clinical management decisions and prioritize genetic testing. This chapter summarizes the most important aspects of genetics and clinical characteristics, together with new genotype-phenotype correlation data.
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Andrés de Pablo, Juan, Luis Javier Serrano, Mariano García-Arranz, Luis Romeu, and Antonio Liras. "Gene and Cell Therapy in Dental Tissue Regeneration." In Human Teeth – Structure and Composition of Dental Hard Tissues and Developmental Dental Defects [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97757.

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Advanced therapies hold substantial promise for the treatment of periodontal conditions. Gene therapy has the potential to transfer “therapeutic” genes, which express proteins such as bone morphogenetic proteins, osteoprotegerin, and tissue nonspecific alkaline phosphatase, which is deficient in patients with hypophosphatasia, a condition that affects mineralization of teeth and bone. Transferred genes may also express platelet-derived growth factor, which modulates the growth of periodontal tissue and the alveolar bone. As regards cell therapy, several clinical trials have shown that mesenchymal stem cells, when used with different kinds of scaffolds to enable the required three-dimensional environment, possess a bone regeneration potential that is particularly useful in such disorders as osteoporosis and osteonecrosis, or for regenerating alveolar bone (osseointegration) prior to placing a dental implant. However, much work is still required before these new therapies become true alternatives in routine clinical dental practice. Medical advances require investments, which are usually influenced by the priorities of both politicians and society at large. This will contribute to promoting innovation, efficient treatments, medium- and long-term savings, and a higher quality of life.
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AYDIN, İlhan. "ULUSAL SU ÜRÜNLERİ GEN BANKASI VE BİYOÇEŞİTLİLİĞE ETKİLERİ." In BİYOÇEŞİTLİLİK VE EKOSİSTEMLER. TÜRKİYE BİLİMLER AKADEMİSİ, 2023. http://dx.doi.org/10.53478/tuba.978-625-8352-58-0.ch08.

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"The National Fisheries Gene Bank plays a very important role in recording, protecting and examining aquaculture genetic resources in Türkiye. This gene bank functions as a containment site for aquatic genetic resources. It aims to facilitate research into the conservation and seed production of species and preservation of genetic diversity. The National Fisheries Gene Bank prioritizes studying economically valuable species. By collecting and conserving genetic material from different populations, the gene bank ensures that valuable genetic traits and variations are preserved for future use. This genetic diversity can be used for selective breeding programs, improving disease resistance, and increasing the productivity and quality of aquaculture species. The gene bank also supports scientific research on biodiversity and provides a valuable resource for studying the ecological aspects of aquatic organisms. By analyzing the genetic material stored in the gene bank, researchers can gain insight into the genetic makeup, population dynamics and histories of aquatic species. This knowledge is essential for developing effective conservation strategies and understanding the effects of human activities on ecosystems. It also promotes international cooperation and knowledge exchange. By sharing genetic material and information, the gene bank contributes to efforts to conserve biodiversity and support sustainable aquaculture practices. The National Fisheries Gene Bank plays a vital role in the conservation of aquatic genetic resources. It supports scientific research, facilitates sustainable aquaculture practices, and contributes to global initiatives to conserve aquatic biodiversity. By conserving genetic resources and encouraging cooperation, the gene bank ensures the longterm viability of their ecosystems and the sustainable use of water resources."
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Conference papers on the topic "PRIORITIZE GENES"

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Wu, Mengmeng, Wanwen Zeng, Wenqiang Liu, Yijia Zhang, Ting Chen, and Rui Jiang. "Integrating embeddings of multiple gene networks to prioritize complex disease-associated genes." In 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2017. http://dx.doi.org/10.1109/bibm.2017.8217651.

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Janyasupab, Panisa, Apichat Suratanee, and Kitiporn Plaimas. "Heterogeneous data analysis of hypertrophic cardiomyopathy to prioritize important genes." In 2022 26th International Computer Science and Engineering Conference (ICSEC). IEEE, 2022. http://dx.doi.org/10.1109/icsec56337.2022.10049332.

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Yepes, Sally, Margaret Tucker, Hela Koka, Kristine Jones, Aurelie Vogt, Laurie Burdette, Wen Luo, et al. "Abstract 1638: Whole-exome sequencing and protein interaction networks to prioritize candidate genes for cutaneous melanoma susceptibility." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1638.

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Jhee, Jong Ho, Min-Young Song, Byung Gon Kim, Hyunjung Shin, and Soo Youn Lee. "Transformer-Based Gene Scoring Model for Extracting Representative Characteristic of Central Dogma Process to Prioritize Pathogenic Genes Applying Breast Cancer Multi-omics Data." In 2023 IEEE International Conference on Big Data and Smart Computing (BigComp). IEEE, 2023. http://dx.doi.org/10.1109/bigcomp57234.2023.00033.

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Wan, Cen. "Positive Feature Values Prioritized Hierarchical Dependency Constrained Averaged One-dependence Estimators for Gene Ontology Feature Spaces." In 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). IEEE, 2022. http://dx.doi.org/10.1109/bibm55620.2022.9995482.

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Hasanova, Aytakin. "PREDICTIVE GENETIC SCREENING." In The First International Scientific-Practical Conference- “Modern Tendencies of Dialogue in Multidenominational Society: philosophical, religious, legal view”. IRETC MTÜ, 2020. http://dx.doi.org/10.36962/mtdms202029.

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Human, as a species, is very variable, and his variability is at the basis of his social organization. This variability is maintained, in part, by the chance effects of gene assortment and the variation in these genes is the result of mutations in the past. If our remote ancestors had not mutated we would not he here; further, since no species is likely to he able to reduce its mutation rate substantially by the sort of selection to which it is exposed, we may regard mutations of recent origin as part of the price of having evolved. We are here: all of us have some imperfections we would wish not to have, and many of us are seriously incommoded by poor sight, hearing or thinking. Others among us suffer from some malformation due to faulty development. A few are formed lacking some essential substance necessary to metabolize a normal diet, to clot the blood, or to darken the back of the eye. We will all die and our deaths will normally be related to some variation in our immu-nological defences, in our ability to maintain our arteries free from occlusion, or in some other physiological aptitude. This massive variation, which is the consequence both of chance in the distribution of alleles and variety in the alleles themselves, imposes severe disabilities and handicaps on a substantial proportion of our population. The prospects of reducing this burden by artificial selection from counsel¬ling or selective feticide will be considered and some numerical estimates made of its efficiency and efficacy. Screening is a procedure by which populations are separated into groups, and is widely used for administrative and other purposes. At birth all babies are sexed and divided into two groups. Later the educable majority is selected from the ineducable minority; later still screening continues for both administrative and medical purposes. Any procedure by which populations are sifted into distinct groups is a form of screening, the word being derived from the coarse filter used to separate earth and stones. In medicine its essential features are that the population to be screen¬ed is not knowingly in need of medical attention and the action is taken on behalf of this population for its essential good. A simple example is provided by cervical smear examination, the necessary rationale for which must be the haimless and reliable detection of precancerous changes which can be prevented from becoming irreversible. Any rational decision on the development of such a service must be based on a balance of good and harm and any question of priorities in relation to other services must be based on costing. The balance of good and harm is a value judgement of some complexity. In the example of cervical smears anxiety and the consequences of the occasional removal of a healthy uterus must be weighed against the benefits of the complete removal of a cancerous one, and such matters cannot be costed in monetary terms. In fact, even such an apparently simple procedure as cervical screening is full of unknowns and many of these unknowns can only be resolved by extensive and properly designed studies. In genetic screening the matter is even more complicated, since the screening is often vicarious; that is, one person is screened in order to make a prediction on what may happen to someone else, usually their children, who may be un¬conceived or unborn. Further, the action of such screening may not be designed to ameliorate disease, but to eliminate a fetus which has a high chance of an affliction, or to prevent a marriage in which there is a mutual predisposition to producing abnormal children. These considerations impose very considerable dif¬ferences, since the relative values placed on marriage, on having children within marriage, and on inducing abortion, vary widely between individuals and between societies.
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Reports on the topic "PRIORITIZE GENES"

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Дирда, Ірина Анатоліївна, Марина Вікторівна Малоіван, and Анна Олександрівна Томіліна. The peculiarities of headlines in English discourse through the examples from Daily Mail and the New Yorker. Видавнича група «Наукові перспективи», May 2023. http://dx.doi.org/10.31812/123456789/7074.

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The paper in question outlines the main peculiarities of the phenomenon of headlines in terms of English discourse. Headlines are thought to be a critical component of journalism and media, as they shape initial readers’ impressions of a story serving as the first point of their contact. Using a corpus of headlines from various English-language publications (to be more precise, those of The Daily Mail and The New Yorker) the paper studies the linguistic features and strategies used in them. According to the conducted analysis it has been revealed that a range of linguistic devices, such as puns, alliteration, and rhyme are typical for headlines the use of which is justified by the desire to grab readers’ attention and make the headline more catchy. Additionally, headlines frequently employ exaggeration, hyperbole, and sensationalism to appeal to readers’ emotions and generate clicks. However, the study also finds that headlines can vary significantly across different genres and publications. For example, tabloid newspapers tend to prioritize sensationalism and entertainment value, while more serious publications tend to employ more understated and informative headlines. The relevance of the study is determined as well by the significant expansion of the influence of the media on society, as well as the growing interest in the methods by which this influence is strengthened. Overall, the paper sheds light on the complex and multifaceted phenomenon of headlines implemented in English discourse. By understanding the linguistic and rhetorical strategies employed in headlines, readers can better assess the accuracy and credibility of the suggested information and gain a more nuanced understanding of current events.
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Tel-Zur, Neomi, and Jeffrey J. Doyle. Role of Polyploidy in Vine Cacti Speciation and Crop Domestication. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7697110.bard.

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1. Abstract: Over the past 25 years, vine cacti of the genera Hylocereus and Selenicereus have been introduced into Israel and southern California as new exotic fruit crops. The importance of these crops lies in their high water use efficiency and horticultural potential as exotic fruit crops. Our collaboration focused on the cytological, molecular and evolutionary aspects of vine cacti polyploidization to confront the agricultural challenge of genetic improvement, ultimately to improve success of vine cacti as commercial fruit crop plants. More specifically, we worked on the: 1- Identification of the putative ancestor(s) of the tetraploid H. megalanthus; 2- Determination of the number of origins of H. megalanthus (single vs. multiple origins of polyploidy); 3- Cytogenetic analysis of BC1 and F1 hybrids; 4- Determination of important agricultural traits and the selection of superior hybrids for cultivation. The plant material used in this study comprised interspecific Hylocereus F1 and first backcross (BC1) hybrids, nine Hylocereus species (58 genotypes), nine Selenicereus species (14 genotypes), and four Epiphyllum genotypes. Two BC1 hexaploids (BC-023 and BC-031) were obtained, a high ploidy level that can be explained only by a fertilization event between one unreduced female gamete from the triploid hybrid and a balanced gamete from the pollen donor, the diploid H. monacanthus. These findings are scientific evidence that support the possibility that “hybridization followed by chromosome doubling” could also occur in nature. Cytomixis, the migration of chromatin between adjacent cells through connecting cytoplasmatic channels, was observed in vine cacti hybrids and may thus imply selective DNA elimination in response to the allopolyploidization process. Evidence from plastid and nrDNA internal transcribed spacers (ITS) sequences support the placement of H. megalanthus within a monophyletic Hylocereus group. Furthermore, both plastid and ITS datasets are most consistent with a conclusion that this tetraploid species is an autopolyploid, despite observations that the species appears to be morphologically intermediate between Hylocereus and Selenicereus. Although the possibility of very narrow allopolyploidly (i.e., derivation from parents that are barely diverged from each other such as closely related species in the same genus) cannot be ruled out entirely based on our data (in part due to the unavailability of Hylocereus species considered to be morphologically the closest relatives of H. megalanthus), the possibility of H. megalanthus representing an intergeneric cross (i.e., Hylocereus × Selenicereus) seems extremely unlikely. Interestingly, the process of homogenization of ITS sequences (concerted evolution) is either incomplete or lacking in both Hylocereus and Selenicereus, and the inclusion of several artificial hybrids in the molecular study revealed the potential for biparental plastid inheritance in Hylocereus. The most important agricultural implication of this research project was the information collected for F1 and BC1 hybrids. Specifically, this project concluded with the selection of four superior hybrids in terms of fruit quality and potential yields under extreme high temperatures. These selected hybrids are self-compatible, avoiding the need for hand cross pollination to set fruits, thus reducing manpower costs. We recently offered these hybrids to growers in Israel for prioritized rapid evaluation and characterization.
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