Academic literature on the topic 'Primary heart involvement'
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Journal articles on the topic "Primary heart involvement"
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Allanore, Yannick, and Andre Kahan. "Primary Heart Involvement in Systemic Sclerosis." Current Rheumatology Reviews 2, no. 3 (August 1, 2006): 245–49. http://dx.doi.org/10.2174/157339706778019593.
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Kumar, Susheel. "Skin Involvement in Primary Systemic Amyloidosis." Mediterranean Journal of Hematology and Infectious Diseases 5, no. 1 (January 2, 2013): e2013005. http://dx.doi.org/10.4084/mjhid.2013.005.
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Primary systemic amyloidosis is a rare disease. It primarily involves kidney, heart, peripheral nerves and liver. Intracutaneous hemorrhage manifesting in the form of petechiae, purpura and ecchymoses due to infiltration of blood vessel walls by amyloid deposits are the most common skin lesions. We report a case of primary systemic amyloidosis with multiple, non-itchy, papular lesions in lower eyelids and lower chest wall bilaterally. Diagnosis was confirmed in this case by biopsy of skin lesions using congo red staining. Papular eruptions as seen in index patient are relatively uncommon form of skin manifestations.
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Ross, Laura, David Prior, Susanna Proudman, Alessandra Vacca, Murray Baron, and Mandana Nikpour. "Defining primary systemic sclerosis heart involvement: A scoping literature review." Seminars in Arthritis and Rheumatism 48, no. 5 (April 2019): 874–87. http://dx.doi.org/10.1016/j.semarthrit.2018.07.008.
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Flores-Umanzor, Eduardo Josué, Paula Sánchez-Somonte, Ana García-Álvarez, and Marta Farrero. "Heart failure due to primary cardiac involvement in systemic sclerosis." Cardiocore 53, no. 1 (January 2018): 42–44. http://dx.doi.org/10.1016/j.carcor.2016.10.001.
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Trukhin, Ivan V., Dmitrij Yu Schekochikhin, Nina A. Novikova, Anna S. Akselrod, Abram L. Syrkin, Helena A. Syrkina, Alexander E. Grachev, et al. "Heart involvement in AL-amyloidosis. Current state of the issue." Annals of the Russian academy of medical sciences 74, no. 5 (December 4, 2019): 307–16. http://dx.doi.org/10.15690/vramn1184.
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AL cardiac amyloidosis is a relatively rare disorder that belongs to the group of infiltrative cardiomyopathies. Diagnosis of primary amyloidosis is challenging due to many unspecific symptoms and sings, which often leads to late diagnosis when treatment options are limited. Primary amyloidosis particularly needs to be excluded in patients with heart failure with preserved ejection fraction. Therapy in cardiac amyloidosis has to main vectors: 1) chemotherapy to eliminate amyloidogenic plasmatic cells 2) heart failure treatment. The main challenge for cardiologists is to support hemodynamics until response to chemotherapy occurs. In the article the issue of diagnostics, risk stratification and treatment of primary cardiac amyloidosis is addressed.
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Bruni, Cosimo, Maya H. Buch, Daniel E. Furst, Giacomo De Luca, Aleksandra Djokovic, Raluca B. Dumitru, Alessandro Giollo, et al. "Primary systemic sclerosis heart involvement: A systematic literature review and preliminary data-driven, consensus-based WSF/HFA definition." Journal of Scleroderma and Related Disorders 7, no. 1 (October 26, 2021): 24–32. http://dx.doi.org/10.1177/23971983211053246.
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Introduction: Primary heart involvement in systemic sclerosis may cause morpho-functional and electrical cardiac abnormalities and is a common cause of death. The absence of a clear definition of primary heart involvement in systemic sclerosis limits our understanding and ability to focus on clinical research. We aimed to create an expert consensus definition for primary heart involvement in systemic sclerosis. Methods: A systematic literature review of cardiac involvement and manifestations in systemic sclerosis was conducted to inform an international and multi-disciplinary task force. In addition, the nominal group technique was used to derive a definition that was then subject to voting. A total of 16 clinical cases were evaluated to test face validity, feasibility, reliability and criterion validity of the newly created definition. Results: In total, 171 publications met eligibility criteria. Using the nominal group technique, experts added their opinion, provided statements to consider and ranked them to create the consensus definition, which received 100% agreement on face validity. A median 60(5–300) seconds was taken for the feasibility on a single case. Inter-rater agreement was moderate (mKappa (95% CI) = 0.56 (0.46–1.00) for the first round and 0.55 (0.44–1.00) for the second round) and intra-rater agreement was good (mKappa (95% CI) = 0.77 (0.47–1.00)). Criterion validity showed a 78 (73–84)% correctness versus gold standard. Conclusion: A preliminary primary heart involvement in systemic sclerosis consensus-based definition was created and partially validated, for use in future clinical research.
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Boldueva, S. A., I. V. Yarmosh, N. S. Shvets, and V. V. Grokhotova. "Primary systemic amyloidosis with involvement of the heart valued like hypertrophic cardiomyopathy." Kreativnaya kardiologiya 12, no. 3 (2018): 275–83. http://dx.doi.org/10.24022/1997-3187-2018-12-2-275-283.
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Kaderli, A. A., I. Baran, O. Aydin, M. Bicer, T. Akpinar, F. Ozkalemkas, D. Yesilbursa, and S. Gullulu. "Diffuse involvement of the heart and great vessels in primary cardiac lymphoma." European Journal of Echocardiography 11, no. 1 (September 15, 2009): 74–76. http://dx.doi.org/10.1093/ejechocard/jep111.
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Rogowitz, Elisa, Hani M. Babiker, Ravitharan Krishnadasan, Clint Jokerst, Thomas P. Miller, and Michael Bookman. "Heart of Lymphoma: Primary Mediastinal Large B-Cell Lymphoma with Endomyocardial Involvement." Case Reports in Oncological Medicine 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/814291.
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Primary mediastinal B-cell lymphoma (PMBCL) is an uncommon aggressive subset of diffuse large B-cell lymphomas. Although PMBCL frequently spreads locally from the thymus into the pleura or pericardium, it rarely invades directly through the heart. Herein, we report a case of a young Mexican female diagnosed with PMBCL with clear infiltration of lymphoma through the cardiac wall and into the right atrium and tricuspid valve leading to tricuspid regurgitation. This was demonstrated by cardiac MRI and transthoracic echocardiogram. In addition, cardiac MRI and CT scan of the chest revealed the large mediastinal mass completely surrounding and eroding into the superior vena cava (SVC) wall causing a collar of stokes. The cardiac and SVC infiltration created a significant therapeutic challenge as lymphomas are very responsive to chemotherapy, and treatment could potentially lead to vascular wall rupture and hemorrhage. Despite the lack of conclusive data on chemotherapy-induced hemodynamic compromise in such scenarios, her progressive severe SVC syndrome and respiratory distress necessitated urgent intervention. In addition to the unique presentation of this rare lymphoma, our case report highlights the safety of R-CHOP treatment.
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Said, Sameh M., Prabhjot Nijjar, Molly Klein, and Ranjit John. "Left bundle branch block revealing a primary small bowel carcinoid metastasizing to the interventricular septum." Interactive CardioVascular and Thoracic Surgery 31, no. 3 (August 13, 2020): 408–10. http://dx.doi.org/10.1093/icvts/ivaa099.
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Abstract Carcinoid tumours of the heart occur most commonly as a result of metastatic disease and usually affect the right side of the heart. We report a case of a solitary carcinoid metastasis to the interventricular septum without hepatic involvement in a 74-year-old man.
Dissertations / Theses on the topic "Primary heart involvement"
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C, Bruni. "To develop a definition and validated expert recommendations to diagnose primary heart involvement in systemic sclerosis - preliminary pathway to a T2T approach." Doctoral thesis, 2022. http://hdl.handle.net/2158/1264311.
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Systemic sclerosis related primary heart involvement (SSc-pHI) is a leading cause of morbidity and mortality during the disease course. Despite the availability of Expert opinion papers on its detection and evaluation, there is heterogeneity regarding its definition, as well as granularity of data regarding the use of diagnostic tests for its evaluation in SSc. The aim of our study was to create a data- and consensus-driven definition of SSc-pHI and start its valiidation process. Consequently, we aimed at creating a consensus guidance to support clinicians in the screening, diagnosis and monitoring of SSc-pHI. Finally we applied the Consensus guidance retrospectively in a real-life cohort of SSc patients.
Two different systematic literature reviews (SLRs) were carried on, the first aimed at identifying the different features of the possible manifestations of SSc-pHI, the second at gathering information on the diagnostic tests and related parameters used for the evaluation of cardiac involvement. The data derived from the two SLRs were used in Expert meetings, including specialists from the rheumatology, immunology, cardiology, pathology fields, as well as a patient research partner. The first meeting lead to the creation of a definition of SSc-pHI, which was partially validated for faesibility, criterion validity and reliability. The subsequent five meetings lead to the creation of a consensus guidance, composed of overarching principles and guidance statements, covering both the screening, diagnosis and monitoring assessments of SSc-pHI. In addition, SSc-specific echocardiography and cardiac magnetic resonance protocols were proposed, both for clinical core assessments and for optional/research agenda evaluations. The real-life retrospective evaluation of the Consensus guidance showed the added value of identifying at risk SSc-patients and regularly applying screening/diagnostic core evaluations, supporting their role in the detection of SSc-related cardiac events and complications. Future steps will include the prospective application of the consensus statements and the proposed ecocardiography/cardiac magnetic resonance protocol, leading the basis for a standardized detection of SSc-pHI and future testing of medications for its prevention and treatment.
Books on the topic "Primary heart involvement"
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Cesal, Barbara P. Heart to Heart for Primary Grades: Family Involvement in Primary Reading. Innovative Learning, 1993.
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Hagendorff, Andreas. Cardiac involvement in systemic diseases. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0020.
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Systemic diseases are generally an interdisciplinary challenge in clinical practice. Systemic diseases are able to induce tissue damage in different organs with ongoing duration of the illness. The heart and the circulation are important targets in systemic diseases. The cardiac involvement in systemic diseases normally introduces a chronic process of alterations in cardiac tissue, which causes cardiac failure in the end stage of the diseases or causes dangerous and life-threatening problems by induced acute cardiac events, such as myocardial infarction due to coronary thrombosis. Thus, diagnostic methods—especially imaging techniques—are required, which can be used for screening as well as for the detection of early stages of the diseases. Two-dimensional echocardiography is the predominant diagnostic technique in cardiology for the detection of injuries in cardiac tissue—e.g. the myocardium, endocardium, and the pericardium—due to the overall availability of the non-invasive procedure.The quality of the echocardiography and the success rate of detecting cardiac pathologies in patients with primary non-cardiac problems depend on the competence and expertise of the investigator. Especially in this scenario clinical knowledge about the influence of the systemic disease on cardiac anatomy and physiology is essential for central diagnostic problem. Therefore the primary echocardiography in these patients should be performed by an experienced clinician or investigator. It is possible to detect changes of cardiac morphology and function at different stages of systemic diseases as well as complications of the systemic diseases by echocardiography.The different parts of this chapter will show proposals for qualified transthoracic echocardiography focusing on cardiac structures which are mainly involved in different systemic diseases.
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Levy, David. Macrovascular complications, hypertension, and lipids. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198766452.003.0008.
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Premature vascular disease is common in Type 1 diabetes, especially in women and those with long duration. Many studies have identified early vascular involvement, using carotid Doppler and coronary artery calcification. Symptoms of coronary heart disease are often absent or muted, and the best methods for identifying occult coronary heart disease in Type 1 patients are not known. The concept of ideal cardiovascular health is valuable in planning preventive lifestyle and medical interventions. ‘Essential’ hypertension in young Type 1 patients is common, and reflects increased arterial stiffness. Hypertension is invariable in patients with any degree of albuminuria or renal impairment. Statin treatment in patients over 40 years old is recommended, but the evidence base is weak. Statins and ezetimibe are the only agents of prognostic value currently available for prevention of vascular events. Primary prevention with aspirin needs individual assessment. Insulin resistance/metabolic syndrome is frequent in Type 1 diabetes.
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Ruiz-Villalba, Adrián, Nikolaos Frangogiannis, and José Maria Pérez-Pomares. Origin and diversity of cardiac fibroblasts: developmental substrates of adult cardiac fibrosis. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0012.
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Cardiac connective tissues are primarily formed by cardiac fibroblasts (CF) of diverse embryonic origins. Whereas CF specific roles in cardiac morphogenesis remain under-researched, their involvement in adult cardiac fibrosis is clinically relevant. Cardiac fibrosis is a common element of several chronic cardiac conditions characterized by the loss of ventricular wall mechanical function, ultimately driving to heart failure. In the ischaemic heart early reparative fibrosis evidences the very restricted regenerative potential of the myocardium. In non-ischaemic diseases fibrosis is activated by unknown signals. We summarize current knowledge on the origin of CFs and their developmental roles, and discuss the differential disease-dependent response of different CF subpopulations to various pathological stimuli. We also describe the characteristic cell-cell and cell-matrix interactions that determine the fibrotic remodelling of the myocardium. We analyse experimental models for the study of cardiac fibrosis, and suggest future directions in the search for new markers and therapeutic targets.
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Deen, Jason F., and Karen K. Stout. Causes and diagnosis of valvular problems. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0158.
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While valvular heart disease encountered in developing countries is primarily rheumatic in aetiology, in industrialized countries it is largely comprised of degenerative valvular disease. Although less prevalent than ischaemic heart disease, its prevalence increases with older age and increased life expectancy, and therefore represents significant disease burden in aging populations. Transthoracic echocardiography remains the imaging modality of choice for timely delineation of the anatomy and severity of the lesion,although, once identified, may not correlate with symptoms due to clinical latency of disease onset to disease manifestation. Variations of disease severity, which may not meet criteria for intervention, lead to chronicity of disease, while clinically silent lesions may remain undiagnosed—both of these situations may lead to acute illness requiring intensive care management. Stabilization through medical intervention may be required, although many patients with severe disease will need emergent surgical repair, therefore collaborative involvement between intensivists, cardiologists, and cardiovascular surgeons is needed to minimize patient mortality and morbidity.
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Alchi, Bassam, and David Jayne. The patient with antiphospholipid syndrome with or without lupus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0164.
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Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy loss, accompanied by laboratory evidence of antiphospholipid antibodies (aPL), namely anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and antibodies directed against beta-2 glycoprotein 1 (β2GP1). APS may occur as a ‘primary’ form, ‘antiphospholipid syndrome,’ without any known systemic disease or may occur in the context of systemic lupus erythematosus (SLE), ‘SLE-related APS’. APS may affect any organ system and displays a broad spectrum of thrombotic manifestations, ranging from isolated lower extremity deep vein thrombosis to the ‘thrombotic storm’ observed in catastrophic antiphospholipid syndrome. Less frequently, patients present with non-thrombotic manifestations (e.g. thrombocytopaenia, livedo reticularis, pulmonary hypertension, valvular heart disease, chorea, and recurrent fetal loss).The kidney is a major target organ in both primary and SLE-related APS. Renal involvement is typically caused by thrombosis occurring at any location within the renal vasculature, leading to diverse effects, depending on the size, type, and site of vessel involved. The renal manifestations of APS include renal artery stenosis and/or renovascular hypertension, renal infarction, APS nephropathy (APSN), renal vein thrombosis, allograft vasculopathy and vascular thrombosis, and thrombosis of dialysis access.Typical vascular lesions of APSN may be acute, the so-called thrombotic microangiopathy, and/or chronic, such as arteriosclerosis, fibrous intimal hyperplasia, tubular thyroidization, and focal cortical atrophy. The spectrum of renal lesions includes non-thrombotic conditions, such as glomerulonephritis. Furthermore, renal manifestations of APS may coexist with other pathologies, especially proliferative lupus nephritis.Early diagnosis of APS requires a high degree of clinical suspicion. The diagnosis requires one clinical (vascular thrombosis or pregnancy morbidity) and at least one laboratory (LA, aCL, and/or anti-β2GP1) criterion, positive on repeated testing.The aetiology of APS is not known. Although aPL are diagnostic of, and pathogenic in, APS, a ‘second hit’ (usually an inflammatory event) may trigger thrombosis in APS. The pathogenesis of the thrombotic tendency in APS remains to be elucidated, but may involve a combination of autoantibody-mediated dysregulation of coagulation, platelet activation, and endothelial injury.Treatment of APS remains centred on anticoagulation; however, it has also included the use of corticosteroids and other immunosuppressive therapy. The prognosis of patients with primary APS is variable and unpredictable. The presence of APS increases morbidity (renal and cerebral) and mortality of SLE patients.
Book chapters on the topic "Primary heart involvement"
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Guttmann, Oliver P., and Perry Elliott. "Specific heart muscle disorders." In Oxford Textbook of Medicine, edited by Jeremy Dwight, 3489–500. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0355.
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Systemic immune-mediated diseases are autoimmune and autoinflammatory diseases affecting at least two-organ systems. Autoinflammatory diseases are a family of conditions characterized by episodes of unprovoked inflammation in the absence of high autoantibody titres or autoreactive T lymphocytes, reflecting a primary dysfunction of the innate immune system. Autoimmune diseases are characterized by aberrant B, T, and dendritic cell responses with predominantly cell-mediated or autoantibody-mediated responses to self-antigens in genetically susceptible individuals. Cardiovascular involvement is systemic immune-mediated diseases may be occult and often goes undetected, but is associated with a poor prognosis. As any anatomical structure in the heart may be involved, patients can present with one or more features consistent with pericarditis, myocarditis, endocarditis, and vasculitis. There is often no correlation between the extent of systemic disease and cardiac involvement.
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Turcian, Darius, and Vasile Stoicu-Tivadar. "Artificial Intelligence in Primary Care: An Overview." In Studies in Health Technology and Informatics. IOS Press, 2022. http://dx.doi.org/10.3233/shti210896.
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With the increase in computing power and the development of numerous technological devices that facilitate remote work, the involvement of artificial intelligence in medicine has seen a significant increase to help the doctor make decisions and intervene in the medical process and telemedicine. In this paper, we gave an overview of the practical involvement of artificial intelligence through different support systems used in primary medicine or telemedicine and also identified the possibilities and opportunities for the development of new support systems for family medicine. Thus, we identified systems used for primary diagnosis, diagnosis of hypertension, early detection of heart abnormalities, detection of diabetes, support in the prescription process, helping clinicians in the daily workflow by providing certain answers to questions, treatment guidance, determining patient priority for treatment for SARS-CoV-2 infection or early detection of disease, support of artificial ventilation in medical emergency centers, remote support for treatments and medication.
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Bundgaard, Henning, Anna Axelsson, Alex Christensen, and Helle Petri. "The heart in neuromuscular disease: myotonic dystrophy." In ESC CardioMed, 1530–34. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0370.
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Myotonic dystrophy type 1 (DM1) is a multisystemic disease, mainly involving skeletal muscles, the central nervous system, the gastrointestinal tract, and the heart. DM1 is inherited as an autosomal dominant trait. Patients with DM1 have a reduced life expectancy with a mean age at death of approximately 53 years. Fibrosis, fat infiltration, and degeneration are seen in both skeletal muscles and in the myocardium. Cardiac involvement in DM1 patients is a major concern as the cause of death is of cardiac origin in 30% of patients. The major cardiac manifestations, including conduction abnormalities, supraventricular and ventricular arrhythmias, and reduced left ventricular systolic function, may lead to sudden cardiac death (SCD) or death from progressive heart failure. The increased risk of SCD underscores the need for assessment of cardiac involvement in order to prevent SCD. Clinical evaluation at the time of diagnosis and life-long repeated follow-up should include clinical assessment, electrocardiogram, Holter monitoring, and echocardiography. Generally, cardiac manifestations in DM1 patients should be treated according to general guidelines. An important topic to be resolved is whether a subset of patients, not fulfilling traditional criteria for pacemaker implantation, but who are estimated to be at high risk of severe conduction abnormalities, benefit from pacemaker or defibrillator implantation on a primary prophylactic basis.
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Kian, Waleed, Melanie Zemel, Emily H. Kestenbaum, Wafeek Alguayn, Boris Shvarts, Adam A. Sharb, Dina Levitas, Yousef Kian, Nir Peled, and Alexander Yakobson. "Cardiomyopathy Etiologies, Symptoms and Management." In Cardiomyopathy - Disease of the Heart Muscle [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95566.
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Cardiomyopathy can be defined as a structural and functional myocardial disorder that is commonly genetic rather than due to coronary artery, valvular or congenital heart disease. It can be subcategorized into dilated, hypertrophic, restrictive, unclassified, and arrhythmogenic right ventricular cardiomyopathy/dysplasia. They can be further subdivided into primary and secondary cardiomyopathy. Primary includes genetics (HOCM, ARVC/D), mixed (DCM, RCM) or acquired (stress-induced, myocarditis) causes; while secondary cardiomyopathy is derived from the involvement of other organ systems. Cardiomyopathies can be identified by echocardiogram to display the anatomic and functional changes related to each subtype including systolic or diastolic dysfunction. In certain instances, cardiac-MRI or CT are used to further elucidate its specific characteristics such as fatty infiltration and focal hypertrophy. Treatment is very diverse and catered to each individual case. This will all be further elaborated on in the following chapter.
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Lee-Gannon, Theo, Hannah Lehrenbaum, Rahul Sheth, and Pradeep P.A. Mammen. "Clinical Management of DMD-Associated Cardiomyopathy." In Cardiomyopathy - Disease of the Heart Muscle. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98919.
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Over the past decade, cardiomyopathy has become the leading cause of mortality among patients with Duchenne muscular dystrophy (DMD). The majority of DMD patients over the age of 18 experience some degree of cardiac involvement. The primary cardiac manifestations of DMD include progressive left ventricular (LV) wall stress leading to LV dilatation and wall thinning, and the development of cardiac fibrosis, all of which culminate in decreased LV contractility and reduced cardiac output. Mortality in these patients is predominantly related to pump failure and fatal arrhythmias leading to sudden cardiac death. While basic guidelines for the management of cardiomyopathy in DMD patients exist, these recommendations are by no means comprehensive, and this chapter aims to provide further insight into appropriate clinical diagnosis and management of DMD-associated cardiomyopathy. Notably, earlier and more frequent cardiac assessment and care can allow for better outcomes for these patients. Pharmacological treatments typically include an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, beta-adrenergic receptor blockers, mineralocorticoid receptor antagonists, and corticosteroids. Non-pharmacological therapies include automated implantable cardioverter defibrillators and left ventricular assist devices, as well as in rare cases cardiac transplantation. Additionally, many emerging therapies show great promise for improving standards of care. These novel therapies, based primarily on applied gene therapy and genome editing, have great potential to significantly alter the DMD care landscape in the near future.
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Halle, Martin, and Michael Schindler. "Myocarditis in athletes." In The ESC Textbook of Sports Cardiology, edited by Antonio Pelliccia, Hein Heidbuchel, Domenico Corrado, Mats Börjesson, and Sanjay Sharma, 201–9. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198779742.003.0023.
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Myocardial involvement during viral infection is underestimated (∼5%). Most infections are not perceived and resolve spontaneously. Symptoms may be non-specific, but include new onset of angina in a young athlete, chest pain, increased resting and exercise heart rate, increased dyspnoea, palpitations, syncope, and impairment of exercise capacity. Physical examination, ECG, and echocardiography are the primary diagnostic tools, whereas serology has a low sensitivity and is not generally recommended. Cardiac magnetic resonance should be performed in all athletes with suspected myocarditis, which typically reveals late gadolinium enhancement (LGE) with a patchy pattern. Patients without LGE and with ejection function >60% have a good prognosis. Endomyocardial biopsy should only be performed if there is severe impairment of myocardial function. A detailed clinical work-up should be performed for re-evaluation after 3 and 6 months. Eligibility to participate in sport can be given after 3 months for perimyocarditis and 6 months for myocarditis, if clinical examination is normal.
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Alenzi, Fahidah, and David P. D’Cruz. "Recent Advances in SLE Treatment Including Biologic Therapies." In Systemic Lupus Erythematosus - Pathogenesis and Management [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105558.
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Systemic lupus erythematosus (SLE) is a long-term multisystem autoimmune rheumatic disease that can affect the skin, joints, kidneys, lungs, heart, and central nervous system. Clinical manifestations range from mild to severe and life-threatening diseases, which could be associated with poor outcomes, including morbidity, poor quality of life, and mortality. There is no cure for SLE, and the management is guided by organ system involvement, flare prevention, managing comorbidities, and reducing damage accumulation. Hydroxychloroquine is the most common drug that is used to control lupus disease activity. Anifrolumab is an antibody that inhibits all signaling through the type I interferon receptor and is licensed for the treatment of moderate to severe SLE. Voclosporin is a calcineurin inhibitor approved for the treatment of lupus nephritis. Belimumab as a biologic agent has been approved for the management of individuals with SLE and lupus nephritis. Despite the fact that rituximab has failed to meet its primary endpoints in clinical trials for SLE, rituximab can be used according to ACR and EULAR guidelines and is commonly used off-label for severe lupus flares. There is an unmet need for new biologic and novel therapeutic approaches in the management of SLE.
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Joseph, Theyamma, and Jacquline C. Vadasseril. "Diabetes a Silent Killer: A Threat for Cardiorespiratory Fitness." In Cardiorespiratory Fitness - New Topics [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108164.
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Type 2 Diabetes Mellitus (T2DM) is a noncommunicable, lifestyle-related chronic metabolic disorder of global involvement, characterized by elevated blood sugar levels, manifested by hyperglycaemia, polyuria, polydipsia and polyphagia. DM is associated with acute and chronic complications which lead to reduced quality of life, premature morbidity and mortality. T2DM is linked with overweight, obesity, reduced physical activity and a genetic component. T2DM is named a silent killer because the primary disease is silent at the early stage and usually gets diagnosed when presenting with a vascular event such as stroke or heart attack. Impaired cardiorespiratory fitness plays a crucial role in acceleration of cardiovascular complications resulting in premature organ damage, morbidity and mortality. Regular physical activity, resistance training and reduction in sedentary life style along with diet control and drugs help to control DM and prevent or delay complications. This chapter deals with diabetes as a disease, its prevalence, risk factors, signs and symptoms, pathophysiology, pathogenesis and underlying mechanisms, acute and chronic complications, along with measures to enhance cardiorespiratory fitness and control DM and a word of caution to the younger generation to be aware of the silent killer.
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Nohria, Anju. "Infective Endocarditis." In The Brigham Intensive Review of Internal Medicine, 18–26. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199358274.003.0003.
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Infective endocarditis (IE) is an infection of the endocardial surface of the heart. It is characterized by one or more vegetations, which comprise a mass of platelets, fibrin, microorganisms, and inflammatory cells. IE primarily involves the heart valves (native or prosthetic). Other structures may also be involved, including the interventricular septum, the chordae tendineae, the mural endocardium, or intracardiac devices such as a pacemaker. The most common infective causes are bacterial; however, fungal endocarditis can be seen in patients who are immunocompromised. There is controversy about the existence of viral endocarditis. Valvular involvement in IE may lead to congestive heart failure, conduction abnormalities, and myocardial abscesses. Systemic complications in IE include embolization of both sterile and infected emboli, abscess formation, and mycotic aneurysms.
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Thomas, Ursula, Lamarcus J. Hall, Tyra Good, Ansley A. Booker, and Ghangis D. Carter. "Fraternal Organizations and Mentoring." In Advances in Educational Marketing, Administration, and Leadership, 271–91. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-3285-0.ch015.
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The involvement of African American males in the community and in school-based service-learning programs has been an ongoing conversation not only within the African American community but in academia. Often, when we hear of African American males, it is encumbered with negative images and negative associations versus positive ones. The primary push for this case study is to examine the critical nature of mentoring for African American male use within school-based mentoring and community-based mentoring through Black Greek-Letter fraternity. The following case study will examine the mentoring and support initiatives of three fraternities within the Divine Nine Greek-Letter organizations and their specific strategies for engaging youth and developing leadership.
Conference papers on the topic "Primary heart involvement"
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Gess, Joshua, Sushil H. Bhavnani, and R. Wayne Johnson. "Thermal Resistance and PIV Characterization of a Line-Replaceable Compact Liquid-Cooled Server Module for High Performance Computing Platforms." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38866.
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The meteoric growth of social networking involvement along with cost-effective cloud based computing business models are just two reasons why data center power consumption is growing at an alarming rate. Dwindling global energy resources mandate that these data centers be more efficient, especially as our dependence and demand upon them grow. As the data center demand grows, components will be designed with reductions in volume and increases in processor speeds, resulting in increases in heat fluxes which two-phase liquid immersion techniques offer the potential of dissipating. The proposed experimental facility seeks to illustrate how these demands can be met through the integration of a small form factor line replaceable cartridge which contains heated elements meant to simulate components within a high performance computing unit. The facility also consists of thermal support equipment used for heat extraction and rejection to ambient much like one would find in a liquid cooled data center, such as a chiller, fluid pumps, etc. One way to effectively characterize the efficiency of a thermal design technique is to quantify the thermal resistance, and subsequently minimize it as much as possible. Incredibly low module level thermal resistances have been achieved, on the order of 0.13 K/W under pool conditions and as little as 0.10 K/W when flow is introduced within the electronics housing. Trends of the cartridge’s thermal resistance have been explored as exterior chilled water temperatures are varied, over several surface enhancements along with the variation of external chilled water and internal dielectric fluid flow rates. As has been noted by several authors in their study of immersion cooled modules, a condensation limit has been found and trends upon it associated with varying the previously mentioned parameters have also been documented. The effect upon thermal performance of diverting the flow over the primary heating elements in various ways has been explored through the use of Particle Image Velocimetry (PIV). These techniques have been used to illustrate how a new dielectric fluid flow distribution design resulted in increased mass flow rate over critical components within the cartridge.
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Martinelli, Jose, Jessica Ivanovs, and Marcos Martinelli. "GERIATRIC EVALUATION IN 27 CASES OF MUSICAL HALLUCINATION." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda073.
Full textAbstract:
Background: Musical hallucination (AM) is a type of complex auditory hallucination described as hearing musical tones, rhythms, harmonies, and melodies without the corresponding external auditory stimulus. This type of hallucination is relatively rare and is seen less often than other types of hallucination. Such hallucinations can be continuous or intermittent and are usually accompanied by a clear and critical awareness on the part of the patient. AM are found mainly in elderly women with progressive hearing loss, usually due to ear diseases or lesions. They also occur in neurological disorders, neuropsychological disorders (eg dementia) and psychiatric disorders, especially depression. Objective: To evaluate clinical and neuropsychological issues of the elderly with Musical Hallucinations Methods: Twenty-seven outpatient patients clinic of Geriatrics and Gerontology at FMJ from January 2010 to October 2019 were selected Results: Of the 27 patients, 20 were women. The average age was 83.47 years. The most prevalent diseases were systemic arterial hypertension, osteoporosis, diabetes mellitus, hypothyroidism, osteoporosis, chronic obstructive pulmonary disease and dementia syndrome. With the exception of one patient, all had hearing loss. The songs were the most varied from Gregorian chant to lullaby. Many had this picture for months and continuously (day and night). 40% of them had no insight into AM. We emphasize that all these patients sought medical care with the main complaint of musical hallucination. Conclusion: In general, AM has an uninterrupted, fragmentary and repetitive character. They are involuntary, intrusive and have an apparent exteriority. They differ from the simple mental image of auditory sensation in that they appear to come from outside the individual as if they actually hear an external device playing music. Currently, it is estimated that about 2% of elderly people with hearing loss also have AM. The neuropsychological basis of AM is not fully established. The phenomenological study, especially the perception of complex sequences and consistency with previous auditory experience strongly suggest the involvement of central auditory processing mechanisms. Normal musical auditory processing involves several interrelated brain levels and subsystems. While the recognition of elementary sounds is done in the primary auditory cortex, the recognition of musical characteristics such as notes, melody and metric rhythm occur in a secondary and tertiary association center, which in turn, are greatly influenced by regions linked to memory and emotion.
Reports on the topic "Primary heart involvement"
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Watkins, Chris B., Susan Lurie, Amnon Lers, and Patricia L. Conklin. Involvement of Antioxidant Enzymes and Genes in the Resistance Mechanism to Postharvest Superficial Scald Development. United States Department of Agriculture, December 2004. http://dx.doi.org/10.32747/2004.7586539.bard.
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The objective of this research project was to evaluate the involvement of antioxidant enzymes and genes in the resistance mechanism to postharvest superficial scald development using two primary systems: 1. Resistant and susceptible progenies of an apple cross between a scald resistant crab apple, ‘White Angel’ and a scald susceptible cultivar, ‘Rome Beauty’; 2. Heat-treatment of ‘Granny Smith’, which is known to reduce scald development in this cultivar. In 2002 we asked for, and received (October 14), permission to revise our initial objectives. The US side decided to expand their results to include further work using commercial cultivars. Also, both sides wanted to include an emphasis on the interaction between these antioxidant enzymes and the á-farnesene pathway, with the cooperation of a third party, Dr. Bruce Whitaker, USDA-ARS, Beltsville. Background: Superficial scald is a physiological storage disorder that causes damage to the skin of apple and pear fruit. It is currently controlled by use of an antioxidant, diphenylamine (DPA), applied postharvest by drenching or dips, but concern exists about such chemical usage especially as it also involves application of fungicides. As a result, there has been increased emphasis on understanding of the underlying mechanisms involved in disorder development. Our approach was to focus on the oxidative processes that occur during scald development, and specifically on using the two model systems described above to determine if the levels of specific antioxidants and/or antioxidant enzyme activities correlated with the presence/absence of scald. It was hoped that information about the role of antioxidant-defense mechanisms would lead to identification of candidate genes for future transgenic manipulation. Major conclusions, solutions, achievements: Collectively, our results highlight the complexity of superficial scald developmental processes. Studies involving comparisons of antioxidant enzyme activities in different crab apple selection, commercial cultivars, and in response to postharvest heat and 1-methylcyclopropene (1-MCP) treatments, show no simple direct relationships with antioxidant contents and susceptibility of fruit to scald development. However, a correlative relationship was found between POX activity or isoenzyme number and scald resistance in most of the studies. This relationship, if confirmed, could be exploited in breeding for scald resistance. In addition, our investigations with key genes in the á-farnesenebiosynthetic pathway, together with antioxidant processes, are being followed up by analysis of exposed and shaded sides of fruit of cultivars that show different degrees of scald control by 1-MCP. These data may further reveal productive areas for future research that will lead to long term control of the disorder. However, given the complexity of scald development, the greatest research need is the production of transgenic fruit with down-regulated genes involved in á- farnesene biosynthesis in order to test the currently popular hypothesis for scald development.