Relevant bibliographies by topics / Presenile dementia

Academic literature on the topic 'Presenile dementia'

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Published: 4 June 2021
Last updated: 3 March 2023

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Journal articles on the topic "Presenile dementia"

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NAKAMURA, SHIGENOBU. "Senile Dementia and Presenile Dementia." Tohoku Journal of Experimental Medicine 161, Supplement (1990): 49–60. http://dx.doi.org/10.1620/tjem.161.supplement_49.

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Pinhorn, A. "Presenile dementia. Dementia classification misleading." BMJ 306, no. 6888 (May 15, 1993): 1343–44. http://dx.doi.org/10.1136/bmj.306.6888.1343-a.

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Järpe, Sven. "PRESENILE DEMENTIA AND HYDROCEPHALUS." Acta Neurologica Scandinavica 46, S43 (January 29, 2009): 89. http://dx.doi.org/10.1111/j.1600-0404.1970.tb02167.x.

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Lying-Tunell, Ulla, Doris Bergquist, Gerhard Böhmer, Hans Olov Malmlund, Olle Marions, and Berndt Söderborg. "STUDIES IN PRESENILE DEMENTIA." Acta Neurologica Scandinavica 46, S43 (January 29, 2009): 90–92. http://dx.doi.org/10.1111/j.1600-0404.1970.tb02168.x.

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Treves, T., A. D. Korczyn, N. Zilber, E. Kahana, Y. Leibowitz, M. Alter, and B. S. Schoenberg. "Presenile dementia in Israel." Alzheimer Disease & Associated Disorders 1, no. 1 (1987): 44. http://dx.doi.org/10.1097/00002093-198701000-00011.

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Whalley, L., G. McGonigal, B. MacLennan, C. McQuade, J. Starr, and B. Thomas. "Presenile dementia: Authors' reply." BMJ 306, no. 6888 (May 15, 1993): 1343–44. http://dx.doi.org/10.1136/bmj.306.6888.1343-c.

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Treves, T., A. D. Korczyn, N. Zilber, E. Kahana, Y. Leibowitz, M. Alter, and B. S. Schoenberg. "Presenile Dementia in Israel." Archives of Neurology 43, no. 1 (January 1, 1986): 26–29. http://dx.doi.org/10.1001/archneur.1986.00520010022014.

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Wright, Christine E., and Paul L. Furlong. "Visual Evoked Potentials in Elderly Patients with Primary or Multi-Infarct Dementia." British Journal of Psychiatry 152, no. 5 (May 1988): 679–82. http://dx.doi.org/10.1192/bjp.152.5.679.

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Flash and pattern-reversal visual evoked potentials (VEP) were recorded in 35 elderly patients with dementia, and 19 controls of equivalent age. Dementia produced a slowing of the major positive (P2) component of the flash VEP but did not affect the latency of the flash P1 component or the P100 pattern-reversal component. This unusual type of abnormality was found in both primary and multi-infarct types of dementia, and has previously been found in primary presenile dementia. The results show that the VEP can be used for the diagnosis of multi-infarct, and primary presenile and senile dementias.
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Ernst, B., M. A. Dalby, and A. Dalby. "APHASIC DISTURBANCES IN PRESENILE DEMENTIA." Acta Neurologica Scandinavica 46, S43 (January 29, 2009): 99–100. http://dx.doi.org/10.1111/j.1600-0404.1970.tb02173.x.

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Tonkonogy, Joseph, and Gary S. Moak. "Alois Alzheimer on Presenile Dementia." Topics in geriatrics 1, no. 4 (October 1988): 199–206. http://dx.doi.org/10.1177/089198878800100403.

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Dissertations / Theses on the topic "Presenile dementia"

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Newens, Andrew J. "The epidemiology of presenile dementia of Alzheimer type." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386740.

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Williams, Ronald N. "Neuropsychological subgroups of dementia of the Alzheimer's type." Virtual Press, 1991. http://liblink.bsu.edu/uhtbin/catkey/774764.

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The present study considered the notion that Neuropsychological subgroups exist within the diagnosis of Dementia of the Alzheimer's Type (DAT). Specifically, the scores on the Cognitive Examination (CAMCOG) of the Cambridge Index of Mental Disorders in the Elderly for 51 DAT patients and 79 normal adults were analyzed via cluster analysis in an attempt to derive meaningful groupings of patients.Results suggested that the CAMCOG was effective in separating normal from impaired individuals. The results also suggested the existence of 4 subgroups within DAT, which were best interpreted as "levels" or "degrees" of impairment. These levels were characterized by distinctly different CAMCOG subscale profiles. Higher performing groups overall showed greatest deficits in memory functions. The most severely impaired group was characterized by dramatically poorer language skills. Mean ages of the DAT groups was similar so that age alone did not appear to contribute to cluster differences. Moreover, information regarding time since onset of symptoms did not suggest that poorer performance was merely a function of the length of time the disease had progressed. A discriminant analysis revealed that the CAMCOG subscales most effective in separating the groups overall were Abstract Thinking, Orientation, Recent Memory, Learning Memory and CAMCOG total score. The CAMCOG appeared to offer some utility in identifying demented patients and in further describing their varied neuropsychological strengths and weaknesses. Implications for using the CAMCOG in planning for care of DAT patients was discussed. Further research is needed to determine other underlying functions contributing to cluster differences and in identifying everyday functional skills of persons with a given CAMCOG profile.
Department of Educational Psychology
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Woodburn, Kirstie Jane. "Presenile dementia in Lothian, Scotland : a clinical and genetic analysis." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21617.

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The study aim was to identify the population of live patients in the Lothian area of Scotland, with presenile dementia of various aetiologies, and to describe the clinical profiles of each and the patterns of decline which occur, together with any genetic characterisation possible. Cases were identified using the Lothian Psychiatric Case Register. For the demographic data, the CAMDEX (The Cambridge Examination of Mental Disorders of the Elderly) informant interview was used. The behavioural assessment comprised the CAPE-BRS (Clifton Assessment Procedure for the Elderly, Behavioural Rating Scale), the Cornell Depression Scale and the MOUSEPAD, a new behavioural and psychopathological assessment. Of 290 potential cases, 164 (57%) were excluded. Reasons: Death 50 (31%), Unsuitable 40 (24%), Refused 40 (24%), Untraced 23 (14%), Out of area 11 (7%), Of the 126 (43%) seen, 112 (89%) met DSM3R (Diagnostic and Statistical manual of Mental Disorders, Third Edition, Revised) criteria for dementia. 63 (56%) of the 112 were rated as DSM3R severe type. 80 (72%) of the 112 fulfilled the McKhann criteria for Alzheimer's Disease. Full description of the group is available. The genetic testing included Apolipoprotein E, α-1 antichymotrypsin and Very Low Density Lipoprotein Receptor (VLDL-R) allele typing. Important data concerning the services provided and used by this group of patients and their carers has been collected and can be shared with organisations working to find funding for presenile dementia in the health service. This study will provide a thoroughly documented and clinically well worked-up sample. The analysis of the work will help to identify if subgroups exist, according to the patterns of various clinical features, the rates of decline and genetic variations. This would in turn, give a greater chance to plan appropriately for all those involved in caring for and managing these illnesses.
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Abeysinghe, Sonali Champika 1959. "Word association in persons with dementia of the Alzheimer type." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276651.

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In an attempt to characterize the nature of semantic memory impairment in persons with dementia of the Alzheimer type (DAT), a free association task, a definition task, and an associate rank ordering task were administered to 10 mildly and 13 moderately impaired DAT subjects, and 14 normal control subjects. The DAT subjects presented a free association response profile that was markedly different from normal controls. Further, DAT subjects provided meaningful definitions to many of the words used as stimuli in the free association task. Relative to controls, DAT subjects demonstrated a deterioration in their ability to rank order words according to the strength of their association to a stimulus noun. The presently obtained data suggest that the semantic memory impairment in DAT can be characterized, in part, as a deterioration in the associative structure between concepts and a loss of conceptual knowledge.
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Knotek, Peter Cyril 1963. "Consistency of response on a semantic memory task in persons with dementia of the Alzheimer type." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276669.

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The purpose of this investigation was to determine the test-retest response consistency rate on a semantic memory task in persons with dementia of the Alzheimer type (DAT). Ten mildly and 13 moderately impaired DAT subjects and 14 normal controls matched for age, years of education, and estimated IQ participated in this study. The Peabody Picture Vocabulary Test (PPVT) was administered twice to each subject with a seven day inter-test interval. The mild and moderate DAT subjects responded inconsistently to significantly more PPVT items than normal controls. When the effects of guessing were considered, moderate DAT subjects gave significantly more inconsistent PPVT responses than normal controls and mild DAT subjects showed a trend towards giving more inconsistent responses. These results substantiate the conclusion that the impairment of specific conceptual knowledge in DAT subjects cannot be reliably measured with a single administration of a semantic memory task such as the PPVT.
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Clarnette, Roger M. "Predictors of cognitive decline in those with subjective memory complaint." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0245.

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[Truncated abstract] Background: Dementia, largely due to Alzheimer's disease (AD), is a major public health problem. The early identification of disease is an important challenge for clinicians because treatment of AD is now available. A simple and accurate means of stratifying risk for AD and identifying early disease is needed so that risk factor modification and treatment can occur optimally. To date, despite many attempts, an accurate means of standardising an approach to the assessment of subtle cognitive symptoms has not been developed. A subjective complaint of poor memory has been identified as a possible marker for underlying brain disease. This study examines the utility of neuropsychological scores, homocysteine levels, APOE genotyping and brain imaging as predictors of cognitive decline in individuals with subjective memory complaint (SMC). Method Eighty subjects with SMC were recruited from memory clinics and the community (MC: 1). Forty-two control subjects were also examined (MC: 0). CAMDEX was used to describe baseline clinical features. The CAMCOG was used as a global test of cognition and was administered annually for four years. At baseline, neuropsychological testing was administered. Cranial CT scanning, measurement of plasma homocysteine and APOE genotyping were completed. Categorical variables were analysed using chi-square according to Pearson's method. Continuous data was analysed using Student's t-tests and Mann-Whitney tests. A logistic regression model was used to identify independent contributors to the presence of memory complaint. Participants were then matched for age, gender and time to follow-up (up for three years) to determine longitudinal predictors of cognitive decline. ... Baseline CAMCOG scores were greater in the control group (MC:0 = 98.3 ? 2.8, MC:1 94.2 ? 5.5, Z ?4.46, p 0.000). There were no differences in neuropsychological scores, concentration of total plasma homocysteine, APOE genotype or brain scan measurements. Using the Wald stepwise selection method, logistic regression could not be established due to non-convergence regardless of whether or not the continuous variables were re-coded into dichotomous variables. A matching process that created 32 pairs of controls/subjects allowed follow-up analysis. The controls showed significant improvement with time on the CAMCOG unlike subjects (mean ? SD, controls 1.5 ?-3.0, Z - 2.61, p 0.01, subjects 0.2 ? 3.2, Z ? 0.24, p 0.81). The logistic regression analysis showed that group membership could not be defined by any single independent variable. When group membership was abandoned and those with stable scores were compared to those who declined no clear meaningful independent predictors of decline apart from age were identified. Conclusions: Methodological issues such as small sample size and inadequate follow up duration were identified that may have precluded identification of predictive factors for cognitive decline. The results indicate that complaints of memory problems are not associated with established risk factors for Alzheimer's disease and fail to predict objective cognitive decline over three years. Future studies should continue trying to identify robust predictors of cognitive decline in later life.
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Singleton, Andrew B. "Genetic aspects of dementia." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299652.

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Smadja, Annie. "Maladie de Lyme et syndrome démentiel : étude clinique et biologique chez 66 malades d'hôpital psychiatrique." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25125.

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Books on the topic "Presenile dementia"

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1935-, Kertesz Andrew, and Munoz David G, eds. Pick's disease and Pick complex. New York: Wiley-LISS, 1998.

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C, Baldwin Robert, and Murray Michelle, eds. Younger people with dementia: A multidisciplinary approach. London: Martin Dunitz, 2003.

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Dementia, Scottish Action on, ed. Dementia in Scotland: Priorities for care,strategies for change. (Edinburgh): (Scottish Action on Dementia), 1986.

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Osborn, Averil. Developing local services and action for dementia sufferers and their carers: Some principles and pointers. Edinburgh: Age Concern Scotland, 1988.

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Henig, Robin Marantz. The myth of senility: The truth about the brain and aging. Washington, D.C: American Association of Retired Persons, 1985.

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The myth of senility: The truth about the brain and aging. Washington, D.C: American Association of Retired Persons, 1988.

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Maryland. Governor's Task Force on Alzheimer's Disease and Related Disorders. The Maryland report on Alzheimer's disease and related disorders. [Baltimore, Md.]: The Task Force, 1985.

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S, Burns Alistair, ed. Ageing and dementia: A methodological approach. London: E. Arnold, 1993.

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Frontotemporal disorders: Information for patients, families, and caregivers. Bethesda, Md.]: National Institutes of Health, National Institute on Aging, 2010.

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Scarbrough, Michael R. Alzheimer's disease & presenile dementia: Subject analysis with reference bibliography. Washington, D.C: ABBE Publishers, 1987.

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Book chapters on the topic "Presenile dementia"

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Zichlin, Miriam. "Presenile Dementia." In Encyclopedia of Clinical Neuropsychology, 2014. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_1140.

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Zichlin, Miriam. "Presenile Dementia." In Encyclopedia of Clinical Neuropsychology, 1. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-56782-2_1140-2.

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Zichlin, Miriam. "Presenile Dementia." In Encyclopedia of Clinical Neuropsychology, 2792. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-57111-9_1140.

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Treves, Therese, Nelly Zilber, Amos D. Korczyn, Esther Kahana, Yaffa Leibowitz, Milton Alter, and Bruce S. Schoenberg. "The Epidemiology of Alzheimer’s Type Presenile Dementia in Israel." In Advances in Behavioral Biology, 169–75. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2179-8_22.

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Gambi, D., M. Onofrj, M. Basciani, C. Censoni, and A. Faricelli. "Acute effects of L-acetylcarnetine (LAC) on quantitative EEG (QEEG) and visual evoked potentials (VEPS) in patients affected by senile, presenile and alcoholic dementia. Comparison with L-carne tine." In Atherosclerosis and Cardiovascular Diseases, 483–89. Dordrecht: Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-3205-0_64.

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Xia, Weiming, and Dennis J. Selkoe. "Role of presenilin in APP processing and Aβ production." In Neuroscientific Basis of Dementia, 183–91. Basel: Birkhäuser Basel, 2001. http://dx.doi.org/10.1007/978-3-0348-8225-5_21.

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Kudo, Takashi, Kazunori Imaizumi, Taiichi Katayama, Naoya Sato, Yuka Nakano, Yuka Jinno, Yuko Segawa, Junji Takeda, Masaya Tohyama, and Masatoshi Takeda. "Impairment of response to ER stress in presenilin 1 mutant." In Neuroscientific Basis of Dementia, 193–99. Basel: Birkhäuser Basel, 2001. http://dx.doi.org/10.1007/978-3-0348-8225-5_22.

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Yoshiike, Yuji, and Akihiko Takashima. "Presenilin-Based Transgenic Models of Alzheimer’s Dementia." In Neuromethods, 415–37. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-898-0_21.

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Thinakaran, Gopal, Carlos A. Saura, Taisuke Tomita, Toshiyuki Honda, and Takeshi Iwatsubo. "Lessons from presenilin domain analysis: endoproteolytic processing and enhanced Aβ42 production mediated by FAD-linked variants." In Neuroscientific Basis of Dementia, 167–75. Basel: Birkhäuser Basel, 2001. http://dx.doi.org/10.1007/978-3-0348-8225-5_19.

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Morganti, Francesca. "Experiencing Dementia from Inside: The Expediency of Immersive Presence." In Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 55–70. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-25872-6_5.

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Conference papers on the topic "Presenile dementia"

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Innocencio, Giovanna de Camargo, Paulo Roberto Hernandes Júnior, Juliana de Souza Rosa, Patrick de Abreu Cunha Lopes, and Jhoney Francieis Feitosa. "Epidemiological profile of Dementia in the state of São Paulo in the last 5 years." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.175.

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Background: dementia is a syndrome characterized by the presence of a progressive deficit in cognitive function, with interference in social and occupational activities, with risk factors varying with genetic and environmental stressors. The differential diagnosis must identify potentially reversible conditions, of different etiologies, such as metabolic changes, intoxications, and nutritional deficiencies. In primary degenerative dementias and sequelae forms, the etiological diagnosis carries therapeutic and prognostic implications. Objectives: to analyse the current epidemiological profile of dementia in the state of São Paulo in the last 5 years. Methods: a literature review was carried out based on articles available in the Scielo and PubMed database and an observational, descriptive and cross- sectional collection of epidemiological data on dementias available in DATASUS – SUS Hospital Information System (SIH/SUS) – in the last 5 years – January 2016 to December 2020 – assessing the number of hospitalizations, the amount of public spending, mortality rate and permanence. Results: in the analyzed period, 3.105 hospitalizations were observed due to occurrences related to dementia, representing a total expenditure of R$37.847.961,13, with 2017 being the year with the highest number of hospitalizations and responsible for the highest amount spent. The total mortality rate in the 5 years studied was 5,57, corresponding to 173 deaths, with 2020 being the year with the highest rate while 2017 had the lowest rate. The average of the permanence in the hospital was 180 days. Conclusion: patients with dementia need early diagnosis and procedures to reduce the rate of hospitalizations and mortality, as well as public costs. For this, technological innovations, using structural and functional neuroimaging methods, as well as biology and molecular genetics techniques, have presented perspectives for the early diagnosis of dementia.
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Méndez, Lorena López. "Un gesto una historia: proyecto artístico como herramienta de identidad y reminiscencia en personas mayores con Demencia temprana." In IV Congreso Internacional de Investigación en Artes Visuales. ANIAV 2019. Imagen [N] Visible. Valencia: Universitat Politècnica de València, 2019. http://dx.doi.org/10.4995/aniav.2019.8963.

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La presente comunicación, expone un proyecto artístico titulado “Usuario en Línea”, compuesto por un archivo configurado por una serie de fotografías de personas en actitud de trabajar en diferentes profesiones, sujetos anónimos pero reconocibles a través de objetos que configuran la imagen y dan paso a descubrir cuál es el trabajo que desarrolla la persona representada. Este proyecto posteriormente fue vinculado y dio paso a la elaboración de uno de los talleres realizados en el Centro de Referencia Estatal de Atención a Personas con Enfermedad de Alzheimer y otras Demencias (CREA) del Imserso en Salamanca. El Taller denominado “Un gesto una Historia” permitió la conexión con la historia de vida de los participantes y en concreto de sus actividades laborales, las cuales fueron descritas e incluso representadas gráficamente, con el fin de evocar recuerdos y vivencias pasadas. Las obras seleccionadas del proyecto, fueron analizadas con el objetivo de mantener activo el cerebro del usuario, es decir, invitan al espectador a un juego de percepción visual, (Arnheim, 2005), en el que se utiliza el Arte de Camuflaje (Méndez Baiges, 2007) para crear la imagen, donde las personas mayores con Demencia pueden ver objetos que en su conjunto forman una imagen de una persona desarrollando una actividad de la vida diaria (AVD) como es el trabajar. Estas obras nos permiten abrir el diálogo hacia varios caminos, permitiéndonos averiguar cuál y cuantos objetos se esconden tras el cuadro mediante el análisis de su silueta. El ejercicio precisa de atención sostenida y centrada en cada objeto que compone la figura. Este juego visual (Winnicott, 2008) ha sido utilizado con participantes en Fase leve y leve-moderada, obteniendo resultados positivos por el interés que despierta el juego visual y adivinanza entre los y las participantes, generándose episodios de humor y risas compartidas.
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Bertoldi, Lucas de Oliveira Pinto, Beatriz Cassarotti, Isabela Silva Souza, Alana Strucker Barbosa, Eduardo Silveira Marques Branco, Isabela Badan Fernandes, Paula Carolina Grande Nakazato, et al. "Case Report: Creutzfeld- Jakob disease, onset with ataxia and absence of dementia." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.614.

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Context: Creutzfeld Jakob disease, a rare prion disease that leads to rapidly progressive dementia and movement disorders, through its pathophysiology will determine brain damage. Regardless of the cause, the course of the disease will be rapid and will invariably lead to death. Objective: The reason why the case is described is due to the low incidence of this disease and its unusual course in the case described. Case report: A 67-year-old male, had a personal history of smoking and obesity . Referred to our service due to sudden ataxia, in the presence of an unchanged MRI scan. The first sympton started when he woke up with a dizzying and inability to walk due to imbalance. In the initial assessment, the patient had appendicular ataxia in all 4 limbs, with an examination of his mental status without changes. New head MRI exam showing alterations compatible with CJD. Interned with hipotheses diagnoses of Wilson’s disease, encephalitis or CJD, he developed abdominal distension with surgical need and immediately after the procedure he already presented a comatose, spastic, and myoclonic condition compatible with the final phase of CJD, later protein 14-3-3 was found in the CSF. Conclusions: CJD, usually presents with rapidly progressive cognitive deficit associated with movement disorder. In the case presented, initially there was no change in cognition and after an urgent surgical procedure, there was an important advance in a shorter than expected period for the disease.
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Souto, Emília Correia, Carolina Maria Marin, Gustavo Carvalho Costa, Igor Braga Farias, Bruno de Mattos Lombardi Badia, Icaro França Navarro Pinto, Roberta Ismael Lacerda Machado, Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, and Acary Souza Bulle Oliveira. "Family with atypical Parkinsonism due to CHCHD10 gene mutation." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.502.

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Introduction: Parkinson’s disease - PD is the second most common agerelated neurodegenerative disorder. Characterized by a variety of motor and non-motor symptoms that relate to the loss of dopaminergic neurons in the midbrain black substance. Although most cases of PD are sporadic, 5–10% of patients have monogenetic mutations with a description of more than 20 genes for the familial form. Mitochondrial mutation in CHCHD10 has also been reported to be associated with a wide spectrum of neurodegenerative disorders, including PD. Objectives: Description of a rare recently described genetic cause of autosomal dominant parkinsonism. Methodology: Describe the case of a Brazilian woman with atypical parkinsonism due to CHCHD10 pathogenic variant that was followed up in our service. Result: Female, 64 years old. “. He started episodes of imbalance about 5 years ago, with falls, in addition to limb stiffness, worse on the left. 4 years ago, he started myalgia to great efforts with low subsequent tolerance to light effort. 1 year ago with urinary incontinence and choking past of poor performance in physical activities without pre-motor symptoms FAMILY: mother with clinical picture of possible dementia syndrome at age 60, history in the maternal family of myalgia, intolerance to physical exercise and hearing loss in adulthood. EXOMA: presence of variant c.146C > T (p.Ala49Val) in simple heterozygosity without CHCHD10 gene. MRI with thigh muscle hypotrophy in anterior and posterior thigh compartments; slight muscle edema in the legs. Conclusion: Pathogenic variants in the CHCHD10 gene should be considered in cases of atypical parkinsonism, especially in cases of positive familial history of mitochondrial myopathy or dementia.
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Costa, Matheus Gomes Reis, Victor Bertani Andrade, and Carla Jamile Jabar Menezes. "Clinical-epidemiological profile of the patient hospitalized with Dementia in the state of São Paulo." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.451.

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Background: Dementia syndromes have a progressive and varied nature, causing cognitive and functional decay. Therefore, understanding the epidemiology of this disease is important for its screening. Objectives: To present the patients hospitalized in the state of São Paulo clinical-epidemiological profile, between March 2011 and February 2021. Design and settings: Descriptive, retrospective, and quantitative epidemiological study. Methodology: The data were collected in Sistema de Informação Hospitalares do Sistema Único de Saúde. The number of hospitalizations and mortality rate were analyzed, correlating them with sex, color, age group, care type, and year. Results: In 6572 hospitalizations, there was no sex majority. 20.3% of the patients did not present information about color. Among the identified, the majority was white (66.2%) or brown (24.7%). Individuals older than 60 years represented 62.6%, with peak between 70 and 79 years old. White population had the highest mortality rates (7.85 ‰), followed by the black population (7.55 ‰). The mortality rate was higher among women older than 80 years. Mortality in elective care (11.6 ‰) was approximately 4 times higher than in emergency care (2.77 ‰). Conclusions: The profile includes white and brown population, older than 60 years. Higher mortality rates in women older than 80 years may be related to their longer life expectancy. Higher mortality in elective care may indicate greater neurodegenerative diseases presence.
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Oliveira, Danielle de, Marina Grigoli, Paloma Zanarelli, Patrícia Manzine, and Márcia Cominetti. "INCREASED EXPRESSION OF SOLUBLE INACTIVE ADAM10 IN PATIENTS WITH ALZHEIMER’S DISEASE AND TYPE 2 DIABETES MELLITUS." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda003.

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Background: DM2 (type 2 diabetes mellitus) can lead to higher risk of developing AD (Alzheimer’s disease). Previous results show that soluble inactive ADAM10 (A Disintegrin And Metalloprotease 10) plasma levels are increased in AD. Objectives: To compare plasma ADAM10 levels between cognitively healthy participants, patients with AD and with the concomitant presence of AD and DM2. Methods: Plasma samples from 36 individuals aged 60 years or more were analyzed, divided into 4 groups: Cognitively and metabolically preserved, AD, DM2 and concomitant presence of AD and DM2. Blood was collected and plasma was separated by centrifugation. The total protein concentration was determined using the Pierce BCA method. ADAM10 levels were determined by SDS-PAGE analysis followed by western blotting. Human serum albumin levels were used as endogen control. Results: Both AD and DM patients had increased plasma ADAM10 levels compared to control participants and these levels were also higher in patients with both diseases. These preliminary results indicate that changes in the insulin pathway may be related to changes in plasma ADAM10 levels, contributing to the development of AD. Conclusions: This study can contribute to the understanding of the biology of the disease itself, as well as the treatment of this type of dementia, also observing the metabolic state of patients.
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Tavares-Junior, Jose Wagner, Pedro Braga-Neto, Manoel Sobreira Neto, Danilo Oliveira, Carmem Gomes, Safira Gaspar, Emmanuelle Sobreira, Werbety Lucas Feitosa, Leticia Chaves Cunha, and Raquel Montenegro. "LONG-COVID COGNITIVE IMPAIRMENT: COGNITIVE ASSESSMENT AND APOLIPOPROTEIN E (APOE) GENOTYPING CORRELATION IN A BRAZILIAN COHORT." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda030.

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Background: COVID-19 neurological manifestations were demonstrated during the pandemic, including cognitive impairment. Objectives: To determine the prevalence of cognitive and behavioral complaints (such as dementia, MCI or SCD) in a outpatient sample with recent SARS-COV2 infection. Specific: Evaluate the association of cognitive impairment with the presence of the polymorphism found in the APOE gene and with respiratory disease. Methodology: Observational, longitudinal, prospective clinical study. Inclusion criteria: patients with confirmed Covid-19. Patients are evaluated in an outpatient clinic. They are evaluated through a standardized attendance record, with somatic and cognitive neurological assessment. Cognitive assessment involves the application of cognitive (ACER, MMSE and CDR), functional (Pfeffer) and psychiatric (GDS or Beck) screening instruments, in addition to subsequent extensive neuropsychological assessment. In addition, APOE polymorphism is analysed. Preliminary. Results: To date, 191 patients and 11 controls were evaluated. The average age is 46.5 years, with 65.4% female, 79.16% with 8 or more years of schooling, in addition to 57.5% of the sample with cognitive complaints. Conclusions: The results so far in our study demonstrate that cognitive complaints are frequent in patients even in the chronic phase of the disease.
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Casiddu, Niccolò, Francesco Burlando, Claudia Porfirione, and Annapaola Vacanti*. "Si–Robotics: an assistive experimental robot." In Intelligent Human Systems Integration (IHSI 2022) Integrating People and Intelligent Systems. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001025.

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SiRobotics is a European-funded project that involves 17 partners among companies and universities, which worked together to design and develop novel solutions of collaborative assistive ICT robotics with advanced capabilities to support caregivers, users and families in healthcare services, while acting with a socially acceptable behavior. The aim of the project is to support weak users in their daily activities, whether they live in home environments or elder care facilities; assessing the progress of their physical and cognitive decline, i.e. cognitive frailty, dementia, mild cognitive impairment, etc., will enable early diagnosis, objective assessment, therapy control and rehabilitation. Si-Robotics system will be used within the context of elder care facilities or home environments, characterized by the presence of frail people requiring gentle and dedicated attention and interaction, assisted by professional and/or in-formal caregivers and medical operators, working with very scheduled and demanding tasks; a first prototype developed in all its physical and interactional features is being tested in a simulation with real end users. The paper will describe our design process and the following choices, involving the shape and aesthetics of the robot.
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Faur, Maria Eduarda, Emily Stefhani Keil, Gabriel Augusto Corti, Maria Eduarda Angelo de Mendonça Filet, Raddib Eduardo Noleto da Nóbrega de Oliveira, Rafael Pereira Guimarães, Thábata Emanuelle Martins Nunes, Gustavo da Cunha Ribas, Carla Heloísa Cabral Moro, and Alexandre Luiz Longo. "Creutzfeldt-Jakob disease: case report strongly suspicious with 14- 3-3 protein missing." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.059.

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Context: The Creutzfeldt-Jakob disease (CJd) is a rare spongiform encephalopathy caused by a prion. In clinical practice the presence of 14- 3-3 protein can be a insensitive marker of sporadic CJd, well as absent for genetic CJd and new variantes, being susceptible to false negatives. Case report: V.L, male, 57 years old, previously rigid, who presented na insidious picture of memory loss and a progressive functional decline for one month and a half. On admission, he was alert, non-contacting, with evidente myoclonus in the upper and lower members and spasticity in lower members. The picture is compatible with rapidly progressive dementia, and the hypothesis of CJd was suggested. The skull CT showed microangiopathy. Clean looking CSF, negative bacteroscopy, non-reactive VDRL, negative nanquim exam and missing 14-3-3 protein search. EEG recorded abnormal rhythm secondary to moderate diffuse and persistente encouragement of fund activity, indicating mild diffuse brain dysfunction, possibly encephalopatic. Skull MRI, signs of restriction and diffusion compromising the caudate nucleus of the putamen bilaterally and symmetrically, and the parietal córtex, predominantly the left, compatible with CJd. Patient had normal thyroid function and hypovitaminosis of mild B12, corrected with intramuscular injection. Evolved in 25 days to akinetic mutism and died in one month due to bronchial aspiration pneumonia. Conclusions: The CJd is a pathology difficult to diagnose, the 14-3-3 protein research is subject to bias, the clinical and radiological findings strongly indicate CJd.
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Silva, Vinícius de Oliveira, Lucas Costa Lins, and Elton Marcio Marques Coelho. "Clinical-epidemiological profile of the hospitalized patient with Alzheimer in the State of São Paulo." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.701.

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Background: Alzheimer’s Disease (AD) is the most common form of dementia and its prevalence practically doubles every five years from the age of 60. The progression of the disease determines cognitive deterioration, impairment of basic daily activities and the need for multiple hospitalizations. Objectives: Characterize the clinical-epidemiological profile of hospitalizations for Alzheimer’s in the state of São Paulo, in the period from 2015 to 2019. Design and Setting: Epidemiological, descriptive and retrospective study with quantitative analysis. Methods: Data provided from the Hospital Morbidity System (SIH-SUS) of the Ministry of Health. Results: A total of 2270 hospitalizations were identified, with a decrease in the number of hospitalizations over the five years (590 in 2015 and 435 in 2019). There was a predominance in people over 80 years old. About 68% of hospitalizations were on an urgent basis. The mortality rate increased 286.23% between 2015 and 2019, and the region with the highest number of hospitalizations was the greater São Paulo (n=1318). Conclusion: The increase in the mortality rate, associated with the reduction in the number of hospitalizations over the years and the predominance of hospitalizations on an urgent basis, may indicate that hospitalizations occur in the presence of a more severe disease, whether due to better management of moderate disease or late diagnosis of its complications. The predominance of hospitalizations in the greater São Paulo region indicates a centralization of health services and technological resources.
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Reports on the topic "Presenile dementia"

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Hauer, Klaus, Ilona Dutzi, Christian Werner, Jürgen M. Bauer, and Phoebe Ullrich. Implementation of intervention programs specifically tailored for patients with CI in early rehabilitation during acute hospitalization: a scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0067.

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Review question / Objective: What is the current status of implementation of interventional programs on early functional rehabilitation during acute, hospital-based medical care, specifically tailored for older patients with CI and what are the most appropriate programs or program components to support early rehab in this specific population? This study combines a systematic umbrella review with a scoping review. While an umbrella review synthesizes knowledge by summarizing existing review papers, a scoping review aims to provide an overview of an emerging area, extracting concepts and identify the gaps in knowledge. The study focuses on older hospitalized adults (>65 yrs.) receiving ward based early rehabilitation. The focus within this review is on study participants with cognitive impairment or dementia. The study targets at controlled trials independent of their randomization procedure reporting on an early functional rehabilitation during hospitalization. Trials that were conducted in different or mixed settings (e.g. inpatient and aftercare intervention) without a clear focus on hospital based rehabilitation were excluded. The study aim is to identify the presence of CI specific features for early rehabilitation including: CI/dementia assessment, sub-analysis of results according to cognitive status, sample description defined by cognitive impairment, program modules specific for geriatric patients CI.
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