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Journal articles on the topic 'Premenstrual syndrome – Physiological aspects'

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Published: 4 June 2021

Last updated: 20 February 2023

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1

Boyles, Lucy, and Callum Baxter. "Premenstrual syndrome." InnovAiT: Education and inspiration for general practice 14, no. 5 (April 20, 2021): 313–17. http://dx.doi.org/10.1177/1755738021994144.

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Premenstrual syndrome (PMS) is a common condition that affects women, most of whom will be managed in general practice. PMS should be distinguished from the physiological premenstrual symptoms experienced by many women, often not needing medical advice. PMS encompasses psychological, physical and behavioural symptoms that generally occur just before menses. This article aims to guide the assessment of women presenting with PMS, including a brief overview of the epidemiology, aetiology, diagnosis and management.

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2

Indusekhar, Radha, Sa'adatu Bose Usman, and Shaughn O'Brien. "Psychological aspects of premenstrual syndrome." Best Practice & Research Clinical Obstetrics & Gynaecology 21, no. 2 (April 2007): 207–20. http://dx.doi.org/10.1016/j.bpobgyn.2006.10.002.

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3

Matsumoto, Tamaki, Hiroyuki Asakura, and Tatsuya Hayashi. "Biopsychosocial aspects of premenstrual syndrome and premenstrual dysphoric disorder." Gynecological Endocrinology 29, no. 1 (July 19, 2012): 67–73. http://dx.doi.org/10.3109/09513590.2012.705383.

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4

Татарчук, Т. Ф., Н. Ф. Захаренко, and I. П. Маноляк. "Premenstrual syndrome. Pathogenetic aspects of treatment." Reproductive Endocrinology, no. 43 (December 3, 2018): 50–54. http://dx.doi.org/10.18370/2309-4117.2018.43.50-54.

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5

Golubovic, S. M. Tosic, V. Sibinovic, and N. Djordjevic. "499 PSYCHOPATHOLOGICAL ASPECTS OF PREMENSTRUAL SYNDROME." European Journal of Pain 10, S1 (September 2006): S132a—S132. http://dx.doi.org/10.1016/s1090-3801(06)60502-8.

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6

Siegel, Judith. "Premenstrual Syndrome: Psychiatric, Physiological, and Psychosocial Perspectives." Health & Social Work 12, no. 4 (1987): 284–89. http://dx.doi.org/10.1093/hsw/12.4.284.

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7

Пахаренко, Л. В. "Psychological aspects of women with premenstrual syndrome." Family Medicine, no. 3(65) (October 16, 2016): 145–47. http://dx.doi.org/10.30841/2307-5112.3(65).2016.80039.

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8

Assoc, Doreen, and Adam Magos. "Psychological and physiological changes in severe premenstrual syndrome." Biological Psychology 33, no. 2-3 (July 1992): 115–32. http://dx.doi.org/10.1016/0301-0511(92)90027-r.

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9

Khan, Akhtar, Michael Hardway, and Kinza Younas. "Premenstrual dysphoric disorder." InnovAiT: Education and inspiration for general practice 14, no. 4 (February 15, 2021): 234–39. http://dx.doi.org/10.1177/1755738021990414.

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An estimated 8-out-of-10 women experience physiological premenstrual symptoms, 3–30% of these women suffer with symptoms of premenstrual syndrome (PMS) that interfere with daily life, with 1–10% of women suffering from severe PMS symptoms meeting the DSM-5 criteria for diagnosis of premenstrual dysphoric disorder (PMDD). PMDD can be considered a subdivision of PMS and is a combination of psychological, behavioural and physical symptoms that can vary in intensity and presents cyclically during the luteal phase of ovulatory menstrual cycles. The diagnosis of PMDD and PMS depends on the timing of symptoms, the severity of symptoms and their impact on quality of life. Physiological symptoms (feeling bloated, headache, acne, mood changes and constipation) that do not impact on daily activities and quality of life are considered to be physiological premenstrual symptoms rather than PMS. There is no association with age, educational status or employment for PMS or PMDD.

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Katibli, S. "Study of premenstrual syndrome and premenstrual dysphorik disorder in Azerbaijan." European Psychiatry 26, S2 (March 2011): 1667. http://dx.doi.org/10.1016/s0924-9338(11)73371-5.

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ObjectivesThe study is aimed to investigate clinical and social aspects of premenstrual disorders in Azerbaijan.Methods180 women at the age 20–49 from general population have been included in the research. The study used the Premenstrual Symptoms Screening Tool to assess severity of premenstrual symptoms. The women's quality of life was evaluated with QoLS (Quality of life Scale).ResultsThe most prevalent complaints included sleep disorders, fatigue, irritability and depressed mood. These symptoms affected work efficiency or productivity, relationships with co-workers, relationships with family members, social life activities, and home responsibilities. At the same time short-term presentation of these symptoms had limited impact on quality of life indicators attributed to long-term outcomes.ConclusionsThe activities on increasing awareness on premenstrual disorders are recommended as an important component of reproductive health program.

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11

Nappi, Rossella E., Laura Cucinella, David Bosoni, Alessandra Righi, Federica Battista, Pietro Molinaro, Giulia Stincardini, Manuela Piccinino, Roberta Rossini, and Lara Tiranini. "Premenstrual Syndrome and Premenstrual Dysphoric Disorder as Centrally Based Disorders." Endocrines 3, no. 1 (March 16, 2022): 127–38. http://dx.doi.org/10.3390/endocrines3010012.

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Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) encompass a variety of symptoms that occur during the luteal phase of the menstrual cycle and impair daily life activities and relationships. Depending on the type and severity of physical, emotional or behavioral symptoms, women of reproductive age followed for at least two prospective menstrual cycles may receive one of the two diagnoses. PMDD is the most severe form of PMS, predominantly characterized by emotional and behavioral symptoms not due to another psychiatric disorder. PMS and PMDD are common neuro-hormonal gynecological disorders with a multifaceted etiology. Gonadal steroid hormones and their metabolites influence a plethora of biological systems involved in the occurrence of specific symptoms, but there is no doubt that PMS/PMDD are centrally based disorders. A more sensitive neuroendocrine threshold to cyclical variations of estrogens and progesterone under physiological and hormonal therapies is present. Moreover, altered brain sensitivity to allopregnanolone, a metabolite of progesterone produced after ovulation potentiating GABA activity, along with an impairment of opioid and serotoninergic systems, may justify the occurrence of emotional and behavioral symptoms. Even neuro-inflammation expressed via the GABAergic system is under investigation as an etiological factor of PMS/PMDD. Pharmacological management aims to stabilize hormonal fluctuations and to restore the neuroendocrine balance. The rationale of suppressing ovulation supports prescription of combined hormonal contraception (CHC). Its effect on mood is highly variable and depends on biochemical characteristics of exogenous steroids and on type and severity of symptoms. Hormonal regimens reducing the estrogen-free interval or suppressing menstruation seem better choices. Psychoactive agents, such as serotonin reuptake inhibitors (SSRIs), are effective in reducing the symptoms of PMS/PMDD and may be prescribed continuously or only during the luteal phase. Novel therapeutic approaches include inhibition of progesterone receptors in the brain, i.e., with ulipristal acetate, reduced conversion of progesterone with dutasteride, and modulation of the action of allopregnanolone on the brain GABAergic system with sepranolone.

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12

KEENAN, P., R. STERN, D. JANOWSKY, and C. PEDERSEN. "Psychological aspects of premenstrual syndrome I: Cognition and memory." Psychoneuroendocrinology 17, no. 2-3 (May 1992): 179–87. http://dx.doi.org/10.1016/0306-4530(92)90056-d.

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13

Figert, Anne E. "Premenstrual syndrome as scientific and cultural artifact." Integrative Physiological & Behavioral Science 40, no. 2 (April 2005): 102–13. http://dx.doi.org/10.1007/bf02734245.

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14

Mbati, Dorkas Day, Ni Ketut Alit, and Laily Hidayati. "LITERATURE REVIEW: ANALYSIS OF FACTORS AFFECTING PREMENSTRUAL SYNDROME IN GIRLS ADOLESCENT." Indonesian Journal of Community Health Nursing 6, no. 2 (November 30, 2021): 75. http://dx.doi.org/10.20473/ijchn.v6i2.29691.

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Introduction: Premenstrual syndrome in adolescent girls is very disturbing daily activities. Changes such as feeling sensitive or irritable, lack of confidence, difficulty concentrating, crying easily, restlessness and anxiety. Premenstrual syndrome in adolescents causes anxiety so that it can result in decreased interest in activities. The purpose of this study is to explain the factors that influence premenstrual syndrome in adolescent girls based on empirical studies in the last five years.Method: The literature review article search was conducted in five databases (Scopus, Proquest, Pubmed, Science Direct and Google Scholar), the search was conducted from July to August 2020. A prism checklist was used to guide this review. Analyzed and tabulated data on articles. Title, abstract, full text and methodology were assessed to determine the feasibility of the study.Result: There were 10 studies that matched the research inclusion criteria, the studies were divided into two themes, namely the influencing factors of premenstrual syndrome (n= 8) and the impact of premenstrual syndrome (n= 2).Conclusion: Factors that affect premenstrual syndrome include: physiological factors include (age, education, length of menstruation, menstrual cycle, menstrual history, physical activity), nutritional factors include (diet, coffee consumption), psychological factors include (stress, feeling uncomfortable). , feelings of insecurity) and the external factor is the use of the internet. Premenstrual syndrome can physically show in the form of headache, breast tenderness, swelling of the extremities, abdominal and heartburn pain and psychologically shows anxiety, withdrawal, confusion, depression and irritability.

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KEENAN, P., L. LINDAMER, and S. JONG. "Psychological aspects of premenstrual syndrome II: Utility of standardized measures." Psychoneuroendocrinology 17, no. 2-3 (May 1992): 189–94. http://dx.doi.org/10.1016/0306-4530(92)90057-e.

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16

Hodambia, Magaille, and Sindi Dandala. "Body Massa Index with Premenstrual Syndrome in College Students." Journal Wetenskap Health 2, no. 2 (August 4, 2021): 74–79. http://dx.doi.org/10.48173/jwh.v2i2.120.

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Premenstrual syndrome (PMS) symptoms may range from mild to severe. PMS severity is affected by hormonal, psychological, and physiological variables in women. Nutritional status was determined using the body mass index (BMI). According to one research, each kilogram/m2 rise in BMI was linked with a 3% increase in the chance of developing PMS. Respondents with normal height and weight who dominated the results of BMI measures in this study were found to be in the same BMI category as female students experiencing mild PMS. When it comes to female students, there is a significant disparity between BMI and PMS degree levels. There is a strong relationship between BMI and the intensity of PMS symptoms. A significant relationship exists between BMI and PMS degrees in female university students. There is a strong relationship between BMI and the intensity of PMS symptoms.

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17

Mendelevich, D. M., and V. D. Mendelevich. "Gynecologic psychiatry. Current aspects of the problem." Neurology Bulletin XXV, no. 1-2 (September 20, 1993): 104–8. http://dx.doi.org/10.17816/nb105984.

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The general-purpose mechanisms of the formation of psychical phenomena in gynecologic and obstetric pathology are considered, in particular, in climacteric, premenstrual syndrome, castration, pregnancy, amenorrhea, sterility and etc. It is concluded that such physical factors as personal peculiarities of a patient, a type of response to the disease, information of the disease and prospect of the physicians prognosis are significant for the gynecologic pathology.

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18

Perveen, Shagufta, Naila Mairaj, Muniba Maqbool, Ahmad Bilal, and Sara Munir. "Prevalence the Premenstrual Syndrome (PMS) in Pakistani Women." Pakistan Journal of Medical and Health Sciences 16, no. 9 (September 30, 2022): 433–34. http://dx.doi.org/10.53350/pjmhs22169433.

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Objective: to determine the prevalence the premenstrual syndrome (PMS) in Pakistani women of child bearing age and the frequency of practices regarding premenstrual syndrome in Pakistani women of child bearing age. Methodology: this cross sectional study included 250 cases, during 2013. A history was taken regarding their menstrual cycle and an interview was carried out. The answers to the questions on the interview were recorded on previously designed performa. The presence or absence of premenstrual syndrome was noted and the patients were also asked about details of symptoms of premenstrual syndrome and treatment related to it. Results: During the study period,250 women were included in study. Out of 250 women, 174(69.6%) had one or more symptoms of premenstrual syndrome (p<0.0001) 80% had awareness of symptoms regarding premenstrual syndrome and treatment relate to it.(P<0.05). Conclusion: The prevalence of premenstrual syndrome among women under study was high and clinically significant.(p<0.0001). Keywords: Premenstrual syndrome, PMS, PMDD, Dysmorphic Disorder, DSM criteria IV, menstrual cycle

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19

Roy-Byrne, Peter P., David R. Rubinow, Harry Gwirtsman, Christine Hoban, and Gay N. Grover. "Cortisol Response to Dexamethasone in Women with Premenstrual Syndrome." Neuropsychobiology 16, no. 2-3 (1986): 61–63. http://dx.doi.org/10.1159/000118298.

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20

Hamidovic, Ajna, Nhan Dang, Dina Khalil, and Jiehuan Sun. "Association between Neuroticism and Premenstrual Affective/Psychological Symptomatology." Psychiatry International 3, no. 1 (January 26, 2022): 52–64. http://dx.doi.org/10.3390/psychiatryint3010005.

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Neuroticism and premenstrual conditions share pleiotropic loci and are strongly associated. It is presently not known which DSM-5 symptoms of premenstrual syndrome/premenstrual mood disorder are associated with neuroticism. We enrolled 45 study participants to provide prospective daily ratings of affective (“depression”, “anxiety, “anger”, “mood swings”) and psychological (“low interest”, “feeling overwhelmed”, and “difficulty concentrating”) symptoms across two-three menstrual cycles (128 total cycles). Generalized additive modeling (gam function in R) was implemented to model the relationships between neuroticism and the premenstrual increase in symptomatology. Significance level was adjusted using the False Discovery Rate method and models were adjusted for current age and age of menarche. Results of the association analysis revealed that “low interest” (p ≤ 0.05) and “difficulty concentrating” (p ≤ 0.001) were significantly associated with neuroticism. None of the remaining symptoms reached statistical significance. The late luteal phase of the menstrual cycle is characterized by complex symptomatology, reflecting a physiological milieu of numerous biological processes. By identifying co-expression between neuroticism and specific premenstrual symptomatology, the present study improves our understanding of the premenstrual conditions and provides a platform for individualized treatment developments.

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21

Amiel Castro, R. T., E. A. Pataky, and U. Ehlert. "Associations between premenstrual syndrome and postpartum depression: A systematic literature review." Biological Psychology 147 (October 2019): 107612. http://dx.doi.org/10.1016/j.biopsycho.2018.10.014.

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22

Hou, Lulu, Yamei Huang, and Renlai Zhou. "Premenstrual syndrome is associated with altered cortisol awakening response." Stress 22, no. 6 (May 6, 2019): 640–46. http://dx.doi.org/10.1080/10253890.2019.1608943.

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23

Nikbakht, Anahita, and Parisa Gazerani. "Premenstrual Syndrome Characteristics in Caucasian and Asian Women: A Survey - Based Study in Denmark." Current Opinion in Gynecology and Obstetrics 1, no. 1 (December 20, 2018): 111–19. http://dx.doi.org/10.18314/cogo.v1i1.1295.

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Women of reproductive age present one or more emotional or physical symptoms in premenstrual phase of their menstrual cycle, which is collectively called premenstrual syndrome (PMS). Estimates show that about 5 to 8% of women suffer from severe PMS. This form has been termed as premenstrual dysphoric disorder (PMDD). Diagnostic criteria have been proposed for PMDD. For the purpose of this research work, the term PMS was used to include variants of premenstrual syndrome in general. Common symptoms include but not limited to breast swelling, food cravings, bloating, mood swings and backache. The etiology of PMS remains unclear; but available evidence suggests that genetics and environmental factors may influence the PMS experience and its severity. The present study was designed to investigate PMS experience and characteristics in two ethnic groups of Caucasian and Asian women living in Denmark. An online survey-based methodology was applied to target Asians and Caucasians women (18-55 years) with PMS, living in different regions in Denmark. The questionnaire consisted of 36 questions to cover the required information for the purpose of this study. Regression analysis was applied to find the association between PMSassociated factors and ethnicity. Asian (47) in comparison with Caucasian women (47) presented with higher ratings of several PMS symptoms such as mood swings, depression and food cravings (p < 0.05). Asian women were also found with higher rate in digestion problems (p < 0.05) and higher rate of cramps and nausea during menstruation and a shorter menstruation period compared with the Caucasians (p < 0.05). This study highlighted that Asian women had higher rates of both psychological and physiological factors in relation to PMS. Potential reasons for a difference between Asian and Caucasian women living in Demark is not clear, and need further investigation.

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Padma, I. V., Kala Madhuri, and Farheen Fatima. "PMS (Premenstrual Syndrome) Symptoms in Adolescent Girls and Correlation of Physiological, Psychological and EEG Findings." International Journal of Physiology 4, no. 2 (2016): 147. http://dx.doi.org/10.5958/2320-608x.2016.00069.x.

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25

Kwon, Yu-Jin, Da-In Sung, and Ji-Won Lee. "Association among Premenstrual Syndrome, Dietary Patterns, and Adherence to Mediterranean Diet." Nutrients 14, no. 12 (June 14, 2022): 2460. http://dx.doi.org/10.3390/nu14122460.

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Premenstrual syndrome (PMS) adversely affects the physiological and psychological health and quality of life of women. Mediterranean diet (MD) could be helpful for managing and preventing PMS, but evidence on the association between dietary patterns and PMS in Asian women is limited. This study aimed to investigate the association of dietary patterns and adherence to MD with PMS in Korean women. This cross-sectional study recruited 262 women aged 20–49 years via an online survey. PMS was diagnosed using the American College of Obstetricians and Gynecologists diagnostic criteria. MD adherence was assessed using the Korean version of the Mediterranean Diet Adherence Screener. Mediterranean Diet Score (MDS) was classified into tertiles (T) (T1: 0–3, T2: 4–5, and T3: ≥6). Dietary pattern was assessed with the Food Frequency Questionnaire. Multiple logistic regression analyses were conducted to evaluate the association between dietary pattern scores and PMS prevalence. The proportion of PMS was significantly lower in MDS tertile (T) 3 than in T1 (55.4% in T3 vs. 74.4% in T1, p = 0.045). After adjusting for confounders, participants in the highest tertile of the bread/snack pattern had a higher risk of PMS (odds ratio [95% CI]: 2.59 [1.32–5.06]), while traditional dietary pattern and meat/alcohol pattern were not associated with PMS. In conclusion, we found that low adherence to MD and higher bread/snack dietary pattern were associated with increased risk of PMS, respectively.

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SHAPIRO, F., and I. NIR. "Stunting Syndrome in Broilers: Physical, Physiological, and Behavioral Aspects." Poultry Science 74, no. 1 (January 1995): 33–44. http://dx.doi.org/10.3382/ps.0740033.

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27

Satyanath, R. Kodidala, J. Sorout, S. Jayachandra, A. Gandhi, and S. Kacker. "Physiological and clinical aspects in COVID-19." RUDN Journal of Medicine 24, no. 3 (December 15, 2020): 201–6. http://dx.doi.org/10.22363/2313-0245-2020-24-3-201-206.

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There is a new public health crises threatening globally with the emergence and spread of 2019 novel corona virus (COVID-19) or the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). In very recent decade we have seen endemic outbreaks in the form of Middle East respiratory syndrome coronavirus (MERS CoV) and severe acute respiratory syndrome related coronavirus (SARS-CoV). Now we again see the emergence of another serious outbreak due to a new strain called the SARS-CoV-2 virus. This SARS-CoV-2 initially presented as pneumonia of unknown etiology with group of symptoms including fever, dry cough and shortness of breath in a cluster of patients in December 2019 Wuhan, China. COVID-19 now has quickly became a health emergency now across worldwide. SARS-CoV-2 is a newly emerging human infectious corona virus that causes COVID-19, now this has been recognized as a pandemic by the World Health Organization (WHO) on 11th March, 2020. Because of the pathogenesis and proliferation pathways of COVID-19 are still unknown the development of vaccine was not developed yet and definitive treatment was not implemented. Therefore, in this article, new potential COVID-19 therapies are briefly reviewed. The world is in emergent need for searching of possible medications for COVID-19.

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28

Rezende, Ana Paula Rodrigues, Fernanda Rassi Alvarenga, Marcelo Ramos, Débora Luiza Franken, Juvenal Soares Dias da Costa, Marcos Pascoal Pattussi, and Vera Maria Vieira Paniz. "Prevalence of Premenstrual Syndrome and Associated Factors Among Academics of a University in Midwest Brazil." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 44, no. 02 (February 2022): 133–41. http://dx.doi.org/10.1055/s-0041-1741456.

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Abstract Objective To investigate the prevalence of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in university students, the factors associated with PMS, the most prevalent symptoms, and the interference of symptoms in academic, family, social, and work activities. Methods This cross-sectional study included 1,115 university students aged ≥ 18 years from the University of Rio Verde, Goiás. Premenstrual syndrome and PMDD were identified using the Premenstrual Symptoms Screening Tool. Associations with sociodemographic, behavioral, reproductive, nutritional, and health factors were investigated using the Poisson regression. Results The prevalence of PMS was 46.9% (95% confidence interval [CI] 44.0–49.8), and of PMDD, 11.1% (95% CI 9.3–13.0). The most prevalent symptoms were physical, such as breast tenderness, bloating, e weight gain (73%); followed by psychological ones such as overeating/food cravings, tearful/more sensitive to rejection (> 60%). More than 30% of the patients reported that the symptoms interfered in a moderate-to-severe way in their social and academic activities. After adjusted analysis, PMS was more prevalent in those who were attending the 1st/2nd semester of college (prevalence ratio [PR] 1.44; 95% CI 1.14–1.80), those who consumed alcohol in the last 30 days (PR 1.23; 95% CI 1.04–1.47), and those who had depression (PR 1.49; 95% CI 1.30–1.71). Conclusion Almost half of the university students had PMS and ∼ 11%, PMDD. Physical symptoms were the most common and interfered in a moderate-to-severe way in various aspects of life. Attending the first semesters, consuming alcohol, and having depression were risk factors for PMS. The identification of risk factors for PMS is essential to prevent symptoms and reduce the impact of the syndrome.

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Doyle, Caroline, Holly A. Swain Ewald, and Paul W. Ewald. "Premenstrual Syndrome: An Evolutionary Perspective on Its Causes and Treatment." Perspectives in Biology and Medicine 50, no. 2 (2007): 181–202. http://dx.doi.org/10.1353/pbm.2007.0015.

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Padmavathi, P., S. Raja Sankar, and N. Kokilavani. "Premenstrual Symptoms and Academic Performance Among Adolescent Girls." Asian Journal of Health Sciences 1, no. 1 (December 1, 2013): 20–24. http://dx.doi.org/10.15419/ajhs.v1i1.411.

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Premenstrual syndrome is a psychophysiological stress induced disorder. Stress disturbs the balance of sympathetic and parasympathetic nervous system. Changes in heart rate and blood pressure are the most important physiological response following stress.To correlate the premenstrual symptoms and academic performance among adolescent girls. A correlational survey was adopted for the study Setting: Higher secondary school, NamakkalDistrict. 60adolescentgirlsfulfillingtheinclusioncriteriawereselectedbysimplerandomsamplingtechnique.Allparticipantsweregiven a questionnaire to complete; questions were related to Baseline Proforma of adolescent girls, rating scale on the common premenstrual symptoms, Student life stress Inventory, Academic Demand Distress were given 40 minutes to complete the questionnaire. The findings revealed that, there was significantly higher numbers of symptoms perceived 8.46±2.9 follicular and 7.14±2.8, luteal, p=.001 and higher distress (1.25±0.41 follicular and 1.52±0.31 luteal, p=.003) in the follicular phase than in the luteal phase. The academic demand component of academic stress measured daily frequency and distress associated with assignments, papers, projects/presentation and time studying. Within the follicular phase number of assignments due was significantly correlated to symptom perception and distress (.41, .31, respectively) and the number of projects/presentations due was correlated to symptom distress (.29) at p<.05. There were significant correlations between follicular phase symptom perception and distress, and luteal phase symptom distress with academic demand distress. There was significant correlation between premenstrual symptoms and academic performance.

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Cox, Joanna H., Stefano Seri, and Andrea E. Cavanna. "Sensory aspects of Tourette syndrome." Neuroscience & Biobehavioral Reviews 88 (May 2018): 170–76. http://dx.doi.org/10.1016/j.neubiorev.2018.03.016.

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32

Jarzabek-Bielecka, Grazyna, Malgorzata Mizgier, and Witold Kedzia. "Metrorrhagia iuvenilis and Premenstrual Syndrome as frequent problems of adolescent gynecology with aspects of diet therapy." Ginekologia Polska 90, no. 7 (July 26, 2019): 423–29. http://dx.doi.org/10.5603/gp.2019.0072.

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33

Nugrahmi, Mega Ade, Joserizal Serudji, and Almurdi Almurdi. "Perbedaan Kadar HS-CRP Menurut Indeks Massa Tubuh dan Derajat Pramenstrual Syndrome pada Remaja Usia 18 � 24 Tahun." Jurnal Ilmiah Universitas Batanghari Jambi 18, no. 3 (October 6, 2018): 575. http://dx.doi.org/10.33087/jiubj.v18i3.505.

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Premenstrual syndrome occurs through the mechanism of chronic inflammation. This can be explained through the immune system which plays an important role in many aspects of women's reproductive function, including follicular recruitment, ovulation, implantation, and endometrium (Evans, 2012). The increase in CRP as a marker of inflammatory process/inflammation associated with obesity (Schulz, 2011). Body fat mass, as well as deposits of energy, it also produces adipocytokines and proinflammatory molecules such as interleukin-6 (IL-6) which is a major determinant of CRP gene expression (Wellen, 2003; Nyandak, 2007; Schulz, 2011; Basir, 2012). An increase in inflammatory conditions cause increased hs-CRP protein in the liver. The effect of that increases estrogen levels during the luteal phase which triggers an increase in prostaglandins and causes an inflammatory response.The purpose of this research is to know the difference in the levels of hs-CRP according to Body Mass Index and the degree of premenstrual syndrome.This research is a quantitative research with the kind of analytical research studies. The design of the research was cross sectional study. The study was conducted at the Padang Health Ministry Polytechnic. The population in this study were all fertile women aged 18-24 years who were active in studying at the Padang Health Ministry Polytechnic. The sample of this research were all populations that met the inclusion and exclusion criteria.The results of the research showed a mean difference where the levels of hs-CRP were higher in obese adolescents compared to normal BMI and it also showed a mean difference where the levels of hs-CRP were higher in moderate PMS degrees compared to low PMS degrees with p <0.05.There is a significant relationship between the Body Mass Index and the degree of premenstrual syndrome. It is necessary to have a weight loss program in people with obesity and weight control to keep it in ideal condition, so that it can reduce the increase in complaints on premenstrual syndrome.

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Karthikkeyan, Kanmani, Nirmala N., Thirumalai Kolundhu Subramanian P., Charumathi V., and Dharani B. "Prevalence of menstrual morbidity in adolescents girls: a cross sectional study." International Journal of Research in Medical Sciences 8, no. 3 (February 26, 2020): 863. http://dx.doi.org/10.18203/2320-6012.ijrms20200554.

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Background: Menstruation is said to be a physiological process in women. The word ‘menstruation’ was derived from a Latin word ‘menses’. Menstrual dysfunction was found to affect 75% of adolescent girls which includes dysmenorrhoea, menorrhagia and irregular cycles. Premenstrual syndrome constitutes a group of physical and emotional symptoms which occurs one week before menstrual cycle. It was found to be a cycle disorder which appears in the luteal phase. Adolescent girls are at high risk of developing premenstrual syndrome. Because of menstrual dysfunction and premenstrual syndrome, the adolescent girls are at high risk of menstrual morbidity.Methods: After getting approval from institutional ethical committee of Madras Medical College, the study was carried out in adolescent girls. The study was carried out by giving questionnaire in nearly 505 students for the duration of 6 months. The study participants were explained about the study. The questionnaire was structured so as to obtain information regarding the age at menarche, duration of cycle, awareness about menstruation, source of information regarding menstruation, practices during menstrual cycles, regarding menstrual problems and treatment practices.Results: The average age of participants was 17 years with an SD of 1.5. of 505 participants, about 6% had 45 days frequency, 10% had 38 days frequency and 2% had 60 days frequency of menstrual cycle. It was found around 1% had 8 days duration and 3% had 9 days duration of menstrual cycle. About 13% of Participants had mild flow, 7% had severe flow and 20% had variable quantity of menstrual flow.Conclusions: From this study, it was found that menstrual dysfunction were prevalent among adolescent girls. These were found to cause menstrual morbidity among adolescent girls. Hence it is necessary to educate and create awareness about menstrual morbidity among adolescent girls.

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(Gautam), Nitu kumari singh, and Laxmi Paudyal. "Effectiveness of Structured Teaching Programme Regarding Selected Yoga Techniques to Relieve Symptoms of Premenstrual Syndrome Among Adolescent Girls of Selected High School at Bangalore." Volume 5 - 2020, Issue 8 - August 5, no. 8 (September 17, 2020): 1688–98. http://dx.doi.org/10.38124/ijisrt20aug722.

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Premenstrual syndrome (PMS) is a challenging problem as the psychological changes which occur in adolescent period are much more stressful and complex. Premenstrual syndrome also known as premenstrual tension (PMT) is a collection of emotional symptoms, with or without physical symptoms, related to menstrual cycle of girls. Menstruation is a normal physiological cycle or process in all females of the reproductive age group. However some women, girls feel or affected by menstrual problem. Among those, PMS is one of the disorder and it is mainly due to hormonal imbalance in the body. Yoga which helps to harmonize the mind and breath with the body through various breathing techniques, yoga posture (asanas) and meditation which also helps in relieving pain. Yoga, tailored to chronic low back pain which helps to produce significant reduction in pain and depression. Several yoga poses helps to ease PMS and also help the mind and body to adapt with stress, anxiety and depression making to feel relaxed and calm, as well as enabling us to cope with psychological symptoms of PMS. The study was conducted with the aim to evaluate the effectiveness of structured teaching programme (STP) regarding selected yoga techniques to relieve the symptoms of PMS among adolescent girls. Researcher adopted an evaluatory approach with pre-experimental one group pre-test and post-test design in the study. Self- structured knowledge questionnaire was used to assess the knowledge among adolescent girls regarding selected yoga technique to relieve the symptoms of PMS. Split half method was used to check the Reliability of the Tool and the tool was found reliable ( r= 0.88). probability simple random sampling techniques was used to select 100 adolescent girls from 3 high school. Findings revealed that the post-test knowledge score (26.49±2.48) was higher than pre-test knowledge score (10.25±2.46). The calculated ‘t’value in knowledge (51.34 p<0.05). The study found significant association between knowledge and demographical variables. Study concludes that structured teaching programme was effective in improving the knowledge of adolescent girls regarding Yoga techniques to relieve the symptoms of premenstrual syndrome.

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Keenan, PA, and LA Lindamer. "Non-Migraine Headache Across the Menstrual Cycle in Women With and Without Premenstrual Syndrome." Cephalalgia 12, no. 6 (December 1992): 356–59. http://dx.doi.org/10.1111/j.1468-2982.1992.00356.x.

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Fluctuation of estrogen levels across the menstrual cycle influences migraine headache. In this study, 53 women documented prospectively the incidence and severity of headache daily for an average of three menstrual cycles. Seven of the women met the criteria established by the International Headache Society for migraine with or without aura, while the remaining 46 women failed to do so. Chi-square analysis revealed that, overall, the incidence of non-migraine headache was dependent on day of the cycle (χ2 [1,66] = 247.7, p < 0.001), with more headaches occurring during the perimenstrual phase. The 46 women without migraine were further classified according to NIMH criteria into PMS ( N= 26) and non-PMS groups (n = 26). An association between headache and menstrual cycle phase was noted for both groups ( p < 0.001), although the incidence of severe headache was greater for the PMS women, during both the perimenstrual and intermenstrual phases. Both groups experienced an increase in severe headaches during the perimenstrual phase. The PMS women peaked on the day prior to menstruation, while the non PMS women peaked on the first day of menstruation. There did not appear to be an overall difference in the reporting of mild headache across the cycle between women with or without PMS. These findings suggest that (a) severe headache which does not meet the criteria for migraine with or without aura also may be menstrually related in women with and without PMS and; (b) the as yet unidentified physiological mechanism predisposing some women to PMS may also render them susceptible to more frequent, severe, non-migraine headaches both during the perimenstrual phase and throughout the entire menstrual cycle.

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Артюшкевич, А. С., Т. Б. Людчик, Ю. И. Степанова, and Н. В. Насибянц. "Maxillofacial Lymphadenitis: Anatomical, Physiological and Clinical Aspects." Стоматология. Эстетика. Инновации, no. 2 (November 3, 2021): 201–12. http://dx.doi.org/10.34883/pi.2021.5.2.008.

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В статье представлен аналитический обзор научной отечественной и зарубежной литературы за последние 15 лет, посвященный анатомо-физиологическим и клиническим аспектам лимфаденитов челюстно-лицевой области. Синдром лимфаденопатии (ЛАП) встречается при большой группе различных заболеваний и представляет собой увеличение одной или нескольких групп лимфатических узлов в основном за счет гиперплазии фолликул лимфоидной ткани, что может быть проявлением как реактивных состояний, так и злокачественных процессов. В настоящее время в клинической практике стоматолога во всем мире отмечается увеличение распространенности лимфаденитов челюстно-лицевой области, в том числе у детей, что, с одной стороны, обусловлено неблагоприятной экологической ситуацией, а с другой – изменениями иммунологической реактивности человеческого организма. В связи с этим вопросы дифференциальной диагностики, лечения и профилактики лимфаденитов приобретают особую значимость для современного здравоохранения Республики Беларусь. The article presents an analytical review of the scientific domestic and foreign literature for the last 15 years, devoted to the anatomical, physiological and clinical aspects of lymphadenitis of the maxillofacial region. Lymphadenopathy syndrome (LAP) is occurred in a large group of various diseases and is an enlargement of one or more groups of lymph nodes mainly due to hyperplasia of lymphoid follicles tissue, which can be a manifestation of both reactive states and malignant processes. Currently, in the clinical practice of the dentist around the world, there is an increase in the prevalence of lymphadenitis of the maxillofacial region, including in children. On the one hand it is due to the unfavorable environmental situation, and on the other – changes in the immunological reactivity of the human body. In this regard, the issues of differential diagnosis, treatment and prevention of lymphadenitis are of particular importance for modern healthcare in Republic of Belarus.

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Elin, R. J. "Assessment of magnesium status." Clinical Chemistry 33, no. 11 (November 1, 1987): 1965–70. http://dx.doi.org/10.1093/clinchem/33.11.1965.

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Abstract The adult human body contains approximately 24 g (1 mol) of magnesium--about half in bone and half in soft tissues. Only about 0.3% of the total body magnesium is present in serum, yet the majority of analytical data obtained is from this body fluid. Assessing the magnesium status of an individual is difficult, there being at present no simple, rapid, and accurate test to determine intracellular magnesium, but determination of total and free magnesium in tissues and physiological tests provide some information. Changes in magnesium status have been linked to cardiac arrhythmias, coronary heart disease, hypertension, and premenstrual syndrome. A better understanding of magnesium transport and of factors controlling magnesium metabolism is needed to elucidate the role of magnesium in disease processes.

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Meng, Yao, Lei Chang, Lulu Hou, and Renlai Zhou. "Menstrual attitude and social cognitive stress influence autonomic nervous system in women with premenstrual syndrome." Stress 25, no. 1 (January 2, 2022): 87–96. http://dx.doi.org/10.1080/10253890.2021.2024163.

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Ross, Judith, Andrew Zinn, and Elizabeth McCauley. "Neurodevelopmental and psychosocial aspects of Turner syndrome." Mental Retardation and Developmental Disabilities Research Reviews 6, no. 2 (2000): 135–41. http://dx.doi.org/10.1002/1098-2779(2000)6:2<135::aid-mrdd8>3.0.co;2-k.

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Kulshreshtha, Megha, Naveen Gaur, Varuna Gupta, and Satyanath Reddy Kodidala. "Assessment of cardiovascular sympathetic function tests in premenstrual syndrome patients visiting tertiary care hospital: A case–control study." Asian Journal of Medical Sciences 12, no. 12 (December 1, 2021): 108–13. http://dx.doi.org/10.3126/ajms.v12i12.39593.

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Background: Premenstrual syndrome (PMS) is a stress-induced disorder and is showing a rising prevalence but its etiopathogenesis is not yet understood. Stress disturbs the balance of the sympathetic and parasympathetic nervous system. Alteration in heart rate and blood pressure is the most important physiological response following stress-induced sympathetic changes. Aims and Objectives: The present study was designed to test the hypothesis of an association between sympathetic functions and PMS and to observe the degree of changes (if any) in these sympathetic functions. The study also aims to provide timely interventions to prevent the development of cardiovascular complications and improve lifestyle. Materials and Methods: A Menstrual Distress Questionnaire was used to evaluate physical, emotional, and behavioral symptoms accompanying the menstrual cycle of the subjects who fulfilled the inclusion criteria. Based on the scores obtained by their questionnaire, subjects with the higher scores formed the PMS group, while the age-matched females with low score served as controls. Cardiovascular sympathetic functions were assessed by standardized, simple, non-invasive tests which included Handgrip test and orthostatic hypotension test. Unpaired Student’s t-test was used for statistical analysis. Results: The results revealed that the sympathetic reactivity is insignificantly higher in PMS group during the follicular phase. During the luteal phase, sympathetic activity is significantly increased. Conclusion: PMS involves psychoneuroendocrinal turmoil, thus early screening of high-risk groups and interventions such as relaxation techniques and lifestyle modification can prevent further cardiovascular complications in patients of high sympathetic responses.

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Hermanns-Lê, Trinh, Jean-François Hermanns, Marianne Lesuisse, and Gérald E. Piérard. "Cyclic Catamenial Dermatoses." BioMed Research International 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/156459.

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Circulating sex hormones follow major fluctuations during the ovarian cycle. The so-called premenstrual syndrome represents a global condition grouping the diversity of catamenial disorders. At the skin level, the sebaceous gland activity is obviously modulated by these endocrine fluctuations. In addition, a series of pathological manifestations take place simultaneously in some women. Among them, the most frequent skin condition is represented by catamenial acne. Concurrently, the autoimmune progesterone dermatitis refers to a diversity of skin alterations resulting from an immune reaction to progesterone. It is present under variable clinical aspects. A series of other recurrent skin conditions are not specifically induced but are merely exacerbated at the end of the ovarian cycle.

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Di Filippo, Chiara, Beatrice Bacchi, and Carlo Di Mario. "Novel Aspects of Classification, Prognosis and Therapy in Takotsubo Syndrome." European Cardiology Review 14, no. 3 (December 18, 2019): 191–96. http://dx.doi.org/10.15420/ecr.2019.27.3.

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Takotsubo syndrome (TTS) can be considered a transient form of acute heart failure that mimics an acute coronary syndrome. Although many hypotheses have been formulated, the precise physiopathology of TTS remains unknown. TTS is associated with a heterogeneous clinical course, which ranges from benign to poor outcome, comprising life-threatening phenotypes. In the acute phase, TTS patients may experience complications including left ventricular outflow tract obstruction, cardiogenic shock, arrhythmias and thromboembolic events. Furthermore, after the acute episode, physiological abnormalities can persist and some patients continue to suffer cardiac symptoms. To recognise patients at higher risk earlier, many variables have been proposed and risk stratifications suggested. There is no solid evidence regarding specific therapy and the proper management of TTS patients, either in the acute phase or long term. This review describes the current knowledge regarding diagnostic criteria, prognosis and therapy in TTS.

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Brighenti, Stefania, Selene Schintu, Donato Liloia, and Roberto Keller. "Neuropsychological aspects of Asperger Syndrome in adults: a review." Neuropsychological Trends, no. 24 (November 2018): 63–95. http://dx.doi.org/10.7358/neur-2018-024-brig.

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Sawaguchi, Toshiko. "Comprehensive study on the epidemiological, physiological, and pathological aspects of sudden infant death syndrome." Pathophysiology 10, no. 3-4 (June 2004): 147. http://dx.doi.org/10.1016/j.pathophys.2004.01.001.

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Sawaguchi, Toshiko. "Comprehensive study on the epidemiological, physiological and pathological aspects of sudden infant death syndrome." Early Human Development 75 (December 2003): 1–2. http://dx.doi.org/10.1016/j.earlhumdev.2003.08.002.

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Šrámková, Monika, Michaela Dušková, Jana Vítků, Petr Matucha, Olga Bradnová, Jose De Cordeiro, Luboslav Stárka, and Josef Včelák. "Physiological changes of adipokines during the menstrual cycle." Problems of Endocrinology 62, no. 5 (September 22, 2016): 41–42. http://dx.doi.org/10.14341/probl201662541-42.

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Background. The cyclical effects of hormones during the menstrual cycle (MC) are responsible for driving ovulation. The information about roles of adipokines within the scope of MC are not definite. Leptin plays a role in sexual function and regulating the onset of puberty. Thin girls often fail to ovulate or release an egg from an ovary during menstruation cycles. Leptin also acts on specific receptors in the hypothalamus to inhibit appetite. Levels of leptin are increased in women suffering from premenstrual syndrome.Aim. The aim of our study was to describe physiological changes of selected steroids and adipokines at healthy women during the MC.Methods. Twenty-seven women with regular menstrual cycles were included in the study. Each sample was collected in cooled EDTA tubes, centrifuged at 2000 rpm in a refrigerated centrifuge, and stored at –80 °C. For all samples we measured luteinizing hormone (LH), follicularstimulating hormone (FSH), sex hormone-binding globulin (SHBG), testosterone, dehydroepiandrosterone (DHEA), estradiol, 7α-DHEA, 7β-DHEA, 7-oxoDHEA, 17-hydroxyprogesterone (17-OH P), progesterone, cortisol, adrenocorticotropic hormone (ACTH) by RIA and IRMA. Levels in plasma of hormones associated with food intake (c-peptide, ghreline, GIP, GLP, GLP-1, glucagon, insulin, leptin, PAI-1, resistin and visfatin) were measured using magnetic bead-based multiple assays (x-MAP technology, Luminex Corporation). Two kits were used: the 10-plex Bio-Plex Pro Human Diabetes assay and the 2-plex Bio-Plex Pro Human Adiponectin and Adipsin assay (both Bio-Rad Laboratories).Patient. Twenty-seven women with regular menstrual cycles (cycle length 28±2 days) were included in the study. The average age of the women was 31.8±3.56, and average BMI 22.9±2.8. The women used no hormonal contraceptives or other medicines influencing the production of steroid hormones, and were non-smokers. Before enrollment in the study, all signed informed consent that was approved by the local ethical committee of the Institute of Endocrinology.Intervention. Fasting blood samples were taken in the morning between 7 and 8 am. The first sampling was done at the start of the menstrual cycle (1st or 2nd day). Subsequent samples were taken at regular intervals every three days, for a total of 10 samples taken during the study.Main outcome measures. During the MC we found increased levels of testosterone, estradiol, progesterone, and 17-hydroxyprogesterone during ovulation. SHBG gradually increased after ovulation. There was a significant decrease in resistin levels during ovulation, followed by an increase in the latter part of the cycle. Adipsin showed a notable increase during ovulation, but this increase was not statistically significant.Results. Classical changes in gonadotropins, estrogens and progesterone during the menstrual cycle are accompanied by less striking but significant changes in 17-hydroxyprogesterone and testosterone. No significant changes show dehydroepiandrosterone and its 7-oxygenated metabolites. Adipokines show a tendency to increase during ovulation, while ghrelin and resistin decrease. There is also a remarkable association of sex hormone binging globuline (SHBG) on the day of the cycle.Conclusions. Our results demonstrate that changes to adipokines during the menstrual cycle are not substantial. Differing leptin levels are characteristic for premenstrual syndrome. Precise descriptions of physiological changes in healthy women are important in helping us understand the significance of the changes accompanying various pathological states.

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Prabu, Y. John Sam Arun, and M. Priyanka Israel. "A quasi experimental study to assess the knowledge and attitude regarding premenstrual syndrome among adolescent girls in selected schools at Madurai." Journal of Community Health Management 9, no. 2 (July 15, 2022): 89–92. http://dx.doi.org/10.18231/j.jchm.2022.018.

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Adolescence is a journey from the world of the child to adult. It is a time of physical and emotional change as the body matures. Adolescence is a critical transitional period that includes the biological changes of puberty and the need to negotiate key developmental task and it requires special attention and protection. Health of today’s adolescence is hope for tomorrow’s world The aim of the study is to investigate the knowledge and the attitude of adolescent school girls towards premenstrual syndrome. A quasi experimental research using one group pre-test post-test design was conducted with simple random sample of 100 adolescent girls, Madurai. A structured knowledge on premenstrual syndrome and likert type attitude scale were developed by the researcher to assess the attitude regarding premenstrual syndrome and used to collect data from the participants. The planned teaching programme covered all aspects in it. The knowledge and attitude of the adolescent girls were assessed immediately before and a week after planned teaching programme was conducted.The majority 75(75%) of the adolescent girls belonged to the age group of 15 to 18 years. Nearly three fourths 90(70%) of the adolescent girls attained menarche in the age group of 11 to 16 years. Majority 95(95%) had inadequate knowledge and 5(5%) had moderate knowledge regarding pre menstrual syndrome in the pre-test and 50(50%) of adolescent girls had adequate knowledge, 38(38%) had moderate knowledge and 12(12%) had inadequate knowledge in the post-test (12.4±4.36 to 23.6±8.25 p< 0.05; paired t- test). Majority 56(56%) had neutral attitude, 41(41%) had negative attitude and 3(3%) had positive attitude in the pre test. Majority 48(48%) had positive attitude, 42(42%) had neutral attitude and 10(10%) had negative attitude. The attitude score significantly increased from 11.0±2.21 to 13.9±2.61 (p< 0.05; paired t- test). There was significant positive correlation between post test knowledge and attitude scores (r=0.06). The present study concludes that recently pre menstrual syndrome is a common problem all over the world affecting the quality of life of women significantly. Despite the growing awareness, there remains a considerable deficiency of knowledge and attitude about the symptoms, treatment and home remedies of pre menstrual syndrome. The further research is required for a large population including women from various background for the better assessment and strategize to manage this rising problem. Majority of adolescent reports, stress exacerbates their pre menstrual syndrome. It is important that a healthy culture to be promoted among adolescent girls as well as women through health education. Pre menstrual syndrome, programme KAA dolescent girls.

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Ovsyannikova, Tamara V., and Ilya A. Kulikov. "Hormonal contraception in women of reproductive age: endocrinological aspects." Gynecology 21, no. 1 (February 15, 2019): 65–68. http://dx.doi.org/10.26442/20795696.2019.1.190285.

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Relevance. Woman’s late reproductive age is a period of complex hormonal adjustment, a preparation for menopause onset. Despite a decline in a reproductive potential and accumulation of gynecological and extragenital diseases in this population a gynecologist has to deal with their contraception as well as a treatment of menstrual disorders and a prevention of hyperplastic processes in the genitals. A search for safe and reliable drugs to solve these problems is extremely important in women of late reproductive period. Aim. Based on date of modern clinical and scientific research a relevance of combined oral contraceptives (COCs) for a safe and reliable contraception as well as for some gynecological diseases treatment and female genital organs hyperplastic and neoplastic diseases prevention was determined. Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 10 years was conducted. The review includes articles from peer-reviewed literature, data of domestic and foreign clinical guidelines on contraceptive issues and Cochrane Library reviews. Results. Use administration of microdose COCs in the late reproductive period, when taking into account criteria for their acceptability, provides reliable contraception. Based on Cochrane database systematic reviews (2011-2018) reliable data on COCs non-contraceptive therapeutic and prophylactic properties at menstrual cycle disorders, endometriosis, hyperandrogenemia, premenstrual syndrome and polycystic ovary syndrome are presented. Conclusion. A choice of COC containing ethinyl estradiol 20 µg and gestodene (progestogen III generation) 75 µg, given contraindications and current observation, is a rational, effective and safe. This provides effective family planning and maintenance of reproductive health of women of late and perimenopausal age due to its wide therapeutic and prophylactic properties given woman's body features.

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Sorokin, Genady A., and V. V. Shilov. "HYGIENIC ASPECTS OF CHRONIC FATIGUE AND AGING." Hygiene and sanitation 96, no. 7 (March 27, 2019): 627–31. http://dx.doi.org/10.18821/0016-9900-2017-96-7-627-631.

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The aim of the study was to establish relations between the acute and chronic fatigue of workers, and between chronic fatigue and age dynamics of indices of health. In 859 women, white-collar workers, with normal fatigue at work of various degree and different physiological labor intensity there was determined an annual gain of professional risks (GPR): syndromes of motor, visual, and non-specific chronic fatigue; indices of the physical performance; morbidity with temporary disability. During the year the health is deteriorating both in 59% of women who are very tired at work, and 63% of women with chronic fatigue syndrome. Under a high level of the physiological intensity of labor GPR increases by 2 times for diseases of the cardiovascular system and by 2.2-times for the disorders of the musculoskeletal system. For hygienic evaluation rate of aging working in harmful conditions, there are required values of age population trends in health indices observed in favorable habitat, without the harmful effects of professional and non-professional factors.

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