Relevant bibliographies by topics / Preimplantation embryo

Academic literature on the topic 'Preimplantation embryo'

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Published: 4 June 2021
Last updated: 25 May 2024

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Journal articles on the topic "Preimplantation embryo"

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Il'ková, Gabriela, Pavol Rehák, Jarmila Veselá, štefan Čikoš, Dušan Fabian, Soňa Czikková, and Juraj Koppel. "Serotonin localization and its functional significance during mouse preimplantation embryo development." Zygote 12, no. 3 (August 2004): 205–13. http://dx.doi.org/10.1017/s0967199404002862.

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Serotonin is a neurotransmitter functioning also as a hormone and growth factor. To further investigate the biological role of serotonin during embryo development, we analysed serotonin localization as well as the expression of specific serotonin 5-HT1D receptor mRNA in mouse oocytes and preimplantation embryos. The functional significance of serotonin during the preimplantation period was examined by studying the effects of serotonin on mouse embryo development. Embryo exposure to serotonin (1 μM) highly significantly reduced the mean cell number, whereas lower concentrations of serotonin (0.1 μM and 0.01 μM) had no significant effects on embryo cell numbers. In all serotonin-treated groups a significant increase in the number of embryos with apoptotic and secondary necrotic nuclei was observed. Expression of serotonin 5-HT1D receptor mRNA in mouse oocytes and preimplantation embryos was confirmed by in situ hybridization showing a clearly distinct punctate signal. Immunocytochemistry results revealed the localization of serotonin in oocytes and embryos to the blastocyst stage as diffuse punctate cytoplasmic labelling. It appears that endogenous and/or exogenous serotonin in preimplantation embryos could be involved in complex autocrine/paracrine regulations of embryo development and embryo-maternal interactions.
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Rager, Günter. "Präimplantationsdiagnostik und der Status des Embryos." Zeitschrift für medizinische Ethik 46, no. 2 (April 19, 2000): 81–89. http://dx.doi.org/10.30965/29498570-04602003.

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The debate about preimplantation genetic diagnosis (PGD) has put new life into the discussion about the various preimplantation stages of the human embryo. This article explains the embryological foundations for the description of preimplantation stages, provides an interpretation for the embryological findings (the embryo as a dynamic, self-organising system – twin development and individuality – the embryo as a person in becoming), and discusses problems with respect to individuality and personality of human embryos.
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Bueno, Aline, Yuri Karen Sinzato, Gustavo Tadeu Volpato, Franciane Quintanilha Gallego, Felipe Perecin, Tiago Rodrigues, and Débora Cristina Damasceno. "Severity of prepregnancy diabetes on the fetal malformations and viability associated with early embryos in rats†." Biology of Reproduction 103, no. 5 (September 1, 2020): 938–50. http://dx.doi.org/10.1093/biolre/ioaa151.

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Abstract Preexisting/pregestational diabetes enhances the risk of birth defects. Several factors have been involved during the implantation process, such as cytokines (granulocyte-macrophage–colony-stimulating factor [GM-CSF]). The objective was to evaluate the effects of two levels of diabetes on the redox status of preimplantation embryos during the implantation process to comprehend how both are involved in embryo and fetal viability against maternal diabetes. Female Sprague–Dawley rats received streptozotocin at birth (mild diabetes [MD]) or at adulthood (severe diabetes [SD]) to obtain two experimental diabetes intensities. After confirming the diabetic status, the nondiabetic and diabetic groups were mated around day 110 of life. At gestational day (GD) 21, fetuses were assessed for viability and malformations and ovaries for embryo loss before implantation. Other pregnant nondiabetic and diabetic rats were sacrificed at GD2–4 for maternal and preimplantation embryo oxidative stress markers, maternal serum insulin, uterine fluid GM-CSF, and preimplantation embryo morphological analysis. MD and SD caused abnormal redox levels, lower GM-CSF and insulin levels during the preimplantation period, and embryonic loss before implantation. SD caused lower fetal viability and higher fetal malformation percentages at GD21. The SD dam-derived preimplantation embryos presented lower glutathione levels and higher thiobarbituric acid reactive substances concentration at GD3 and an increased frequency of abnormal preimplantation embryos at GD4. In conclusion, preexisting diabetes leads to complications in the implantation process. Furthermore, maternal oxidative stress and other metabolic changes alter the redox state and morphological structure of preimplantation embryos, contributing to damaged growth and development in late pregnancy.
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Ding, Nai-Zheng, Cheng-Qiang He, and Zeng-Ming Yang. "Quantification of basigin mRNA in mouse oocytes and preimplantation embryos by competitive RT-PCR." Zygote 10, no. 3 (August 2002): 239–43. http://dx.doi.org/10.1017/s0967199402002319.

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Basigin is a member of the immunoglobulin superfamily and a key molecule related to mouse blastocyst implantation. Whether preimplantation mouse embryos express basigin mRNA is still unknown. The aim of this study was to use a quantitative competitive polymerase chain reaction to assess quantitatively the levels of basigin mRNA in mouse oocyte and preimplantation embryos. Basigin mRNA was detected in the oocyte and all the stages of preimplantation embryos. The levels of basigin mRNA were 0.0606 ± 0.0282 in the oocyte, 0.0102 ± 0.0036 in the zygote, 0.0007 ± 0.0003 in the 2-cell embryo, 0.0031 ± 0.0017 in the 4-cell embryo, 0.0084 ± 0.0024 in the 8-cell embryo, 0.0537 ± 0.0121 in the morula and 0.0392 ± 0.0161 attomoles in the blastocyst, respectively. The levels of basigin mRNA in the oocyte, morula and blastocyst were significantly higher than those in the zygote and embryos at the 2-cell, 4-cell and 8-cell stages. The high level of basigin expression in the blastocyst may play a role during embryo implantation.
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Lin, Tao, Jae Lee, Jung Kang, Hyeon Shin, Ju Lee, and Dong Jin. "Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development." International Journal of Molecular Sciences 20, no. 2 (January 18, 2019): 409. http://dx.doi.org/10.3390/ijms20020409.

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Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic reticulum (ER) to maintain oocyte and embryo development. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of ER stress and unfolded protein response (UPR) signaling pathways. ER stress and UPR signaling have been identified in mammalian oocytes and embryos produced in vitro, suggesting that modulation of ER stress and UPR signaling play very important roles in oocyte maturation and the development of preimplantation embryos. In this review, we briefly describe the current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development.
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Duranthon, Veronique, Andrew J. Watson, and Patrick Lonergan. "Preimplantation embryo programming: transcription, epigenetics, and culture environment." REPRODUCTION 135, no. 2 (February 2008): 141–50. http://dx.doi.org/10.1530/rep-07-0324.

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Preimplantation development directs the formation of an implantation- or attachment-competent embryo so that metabolic interactions with the uterus can occur, pregnancy can be initiated, and fetal development can be sustained. The preimplantation embryo exhibits a form of autonomous development fueled by products provided by the oocyte and also from activation of the embryo's genome. Despite this autonomy, the preimplantation embryo is highly influenced by factors in the external environment and in extreme situations, such as those presented by embryo culture or nuclear transfer, the ability of the embryo to adapt to the changing environmental conditions or chromatin to become reprogrammed can exceed its own adaptive capacity, resulting in aberrant embryonic development. Nuclear transfer or embryo culture-induced influences not only affect implantation and establishment of pregnancy but also can extend to fetal and postnatal development and affect susceptibility to disease in later life. It is therefore critical to define the basic program controlling preimplantation development, and also to utilize nuclear transfer and embryo culture models so that we may design healthier environments for preimplantation embryos to thrive in and also minimize the potential for negative consequences during pregnancy and post-gestational life. In addition, it is necessary to couple gene expression analysis with the investigation of gene function so that effects on gene expression can be fully understood. The purpose of this short review is to highlight our knowledge of the mechanisms controlling preimplantation development and report how those mechanisms may be influenced by nuclear transfer and embryo culture.
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Kimber, S. J., S. F. Sneddon, D. J. Bloor, A. M. El-Bareg, J. A. Hawkhead, A. D. Metcalfe, F. D. Houghton, et al. "Expression of genes involved in early cell fate decisions in human embryos and their regulation by growth factors." REPRODUCTION 135, no. 5 (May 2008): 635–47. http://dx.doi.org/10.1530/rep-07-0359.

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Little is understood about the regulation of gene expression in human preimplantation embryos. We set out to examine the expression in human preimplantation embryos of a number of genes known to be critical for early development of the murine embryo. The expression profile of these genes was analysed throughout preimplantation development and in response to growth factor (GF) stimulation. Developmental expression of a number of genes was similar to that seen in murine embryos (OCT3B/4,CDX2,NANOG). However,GATA6is expressed throughout preimplantation development in the human. Embryos were cultured in IGF-I, leukaemia inhibitory factor (LIF) or heparin-binding EGF-like growth factor (HBEGF), all of which are known to stimulate the development of human embryos. Our data show that culture in HBEGF and LIF appears to facilitate human embryo expression of a number of genes:ERBB4(LIF) andLIFRandDSC2(HBEGF) while in the presence of HBEGF no blastocysts expressedEOMESand when cultured with LIF only two out of nine blastocysts expressedTBN. These data improve our knowledge of the similarities between human and murine embryos and the influence of GFs on human embryo gene expression. Results from this study will improve the understanding of cell fate decisions in early human embryos, which has important implications for both IVF treatment and the derivation of human embryonic stem cells.
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Warner, C. M., J. A. Newmark, M. Comiskey, S. R. De Fazio, D. M. O'Malley, M. Rajadhyaksha, D. J. Townsend, et al. "Genetics and imaging to assess oocyte and preimplantation embryo health." Reproduction, Fertility and Development 16, no. 7 (2004): 729. http://dx.doi.org/10.1071/rd04088.

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Two major criteria are currently used in human assisted reproductive technologies (ART) to evaluate oocyte and preimplantation embryo health: (1) rate of preimplantation embryonic development; and (2) overall morphology. A major gene that regulates the rate of preimplantation development is the preimplantation embryo development (Ped) gene, discovered in our laboratory. In mice, presence of the Ped gene product, Qa-2 protein, results in a fast rate of preimplantation embryonic development, compared with a slow rate of preimplantation embryonic development for embryos that are lacking Qa-2 protein. Moreover, mice that express Qa-2 protein have an overall reproductive advantage that extends beyond the preimplantation period, including higher survival to birth, higher birthweight, and higher survival to weaning. Data are presented that suggest that Qa-2 increases the rate of development of early embryos by acting as a cell-signalling molecule and that phosphatidylinositol-3′ kinase is involved in the cell-signalling pathway. The most likely human homologue of Qa-2 has recently been identified as human leukocyte antigen (HLA)-G. Data are presented which show that HLA-G, like Qa-2, is located in lipid rafts, implying that HLA-G also acts as a signalling molecule. In order to better evaluate the second criterion used in ART (i.e. overall morphology), a unique and innovative imaging microscope has been constructed, the Keck 3-D fusion microscope (Keck 3DFM). The Keck 3DFM combines five different microscopic modes into a single platform, allowing multi-modal imaging of the specimen. One of the modes, the quadrature tomographic microscope (QTM), creates digital images of non-stained transparent cells by measuring changes in the index of refraction. Quadrature tomographic microscope images of oocytes and preimplantation mouse embryos are presented for the first time. The digital information from the QTM images should allow the number of cells in a preimplantation embryo to be counted non-invasively. The Keck 3DFM is also being used to assess mitochondrial distribution in mouse oocytes and embryos by using the k-means clustering algorithm. Both the number of cells in preimplantation embryos and mitochondrial distribution are related to oocyte and embryo health. New imaging data obtained from the Keck 3DFM, combined with genetic and biochemical approaches, have the promise of being able to distinguish healthy from unhealthy oocytes and embryos in a non-invasive manner. The goal is to apply the information from our mouse model system to the clinic in order to identify one and only one healthy embryo for transfer back to the mother undergoing an ART procedure. This approach has the potential to increase the success rate of ART and to decrease the high, and undesirable, multiple birth rate presently associated with ART.
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Papaioannou, Virginia E., and Richard R. Behringer. "Phenotypic Analysis of Preimplantation Mouse Embryos in Culture." Cold Spring Harbor Protocols 2023, no. 12 (November 6, 2023): pdb.prot108090. http://dx.doi.org/10.1101/pdb.prot108090.

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Preimplantation embryo culture is a valuable approach to investigate a preimplantation lethal phenotype. Standard culture methods have been perfected such that the entire preimplantation period and the process of implantation can be followed in vitro. This protocol provides modifications for the analysis of clutches of embryos from heterozygous matings specifically for the purpose of distinguishing a preimplantation phenotype in homozygous mutants.
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Delhanty, JDA, and JC Harper. "Preimplantation genetic diagnosis." Reproductive Medicine Review 10, no. 1 (March 2002): 3–20. http://dx.doi.org/10.1017/s096227990200011x.

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The aim of preimplantation genetic diagnosis (PGD) is to give couples at risk of passing on a genetic disorder an alternative to standard prenatal diagnosis by enabling them to start a pregnancy that is known to be free of the familial disease. This can be achieved by generating embryos in vitro by standard in vitro fertilization (IVF) techniques and then removing one to two of the cells from the early embryo (embryo biopsy). Single cell polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH) can then be used to diagnose single gene defects or chromosomal abnormalities respectively. Those embryos diagnosed as free from disease can then be considered for transfer to the womb and so the pregnancy is started knowing that the fetus is unaffected. This avoids the need to consider pregnancy termination in the quest for a healthy child. Originally it was thought that the major reason for referral would be the risk of passing on a single abnormal gene but an increasing proportion of couples are requesting PGD because of recurrent miscarriage due to parental chromosomal abnormality.
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Dissertations / Theses on the topic "Preimplantation embryo"

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Legge, M. "Determinants in preimplantation mouse development." Thesis, University of Essex, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235442.

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Spanos, Sophia. "Cell death during preimplantation embryo development." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398228.

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Partridge, Robert James. "The biochemistry of the bovine preimplantation embryo." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245866.

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Alexiou, Maria. "Purine metabolism in the mouse preimplantation embryo." Thesis, University of York, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317658.

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Orsi, Nicolas Michel. "Cellular stress in the mammalian preimplantation embryo." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274488.

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Du, Zheng Feng. "Studies of embryo metabolism during preimplantation development." Thesis, Du, Zheng Feng (1992) Studies of embryo metabolism during preimplantation development. PhD thesis, Murdoch University, 1992. https://researchrepository.murdoch.edu.au/id/eprint/53045/.

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The experiments reported in this thesis were undertaken to study two aspects of the biology of mammalian preimplantation embryos. The first of these dealt with the utilization of the energy substrate, glucose, by the sheep embryo up to and including day 19 of pregnancy. The second dealt with the utilization of glutamine by mammalian embryos and the reciprocal effects of glutamine and glucose on each others metabolism. This latter study was prompted by the recent reports of the beneficial effects of medium containing glutamine, but excluding glucose, on the ability of mouse zygotes to undergo full preimplantation development in vivo . Prior to undertaking the metabolic studies with glutamine a series of experiments were undertaken to study the capacity of the mouse zygotes of different genetic background to develop in vitro and the constituents of the medium that may influence this development. Initial experiments were carried out to examine the effects of reducing oxygen concentration upon the catabolic and anabolic utilization of glucose by the preimplantation sheep conceptus as it develops and differentiates from the cleaving stage to the 19th day of pregnancy. The results of this study demonstrated that lowering O2 to 5% substantially altered both the catabolic and anabolic metabolism of glucose but the pattern of response depended on the stage at which the conceptus was explanted. Next the activity of the pentose phosphate pathway was estimated in both cleaving embryos and the advanced conceptus. There was a substantial utilization of glucose through this pathway and the activity of the pathway changed with development and differentiation. As it has been proposed that trophoblastic vesicles formed by in vitro culture of fresh trophoblast may be used as a model system for studying the biochemistry and physiology of the preimplantation embryos, a study was undertaken to examine glucose metabolism by sheep trophoblastic vesicles formed from day 13 trophoblast and cultured for 6 days. By assessing catabolic and anabolic metabolism of glucose, it was shown that these vesicles were active in the utilization of glucose but the pattern of metabolism did not mimic that seen with fresh tissue samples. The second major aspect dealt with the role of glutamine in the biology and metabolism of the embryo during preimplantation development. The first experiment investigated the development of mouse zygotes of different genotype through the "2-cell block" and the effect of medium components including glutamine, glucose and EDTA upon this development. The results showed that the glutamine containing medium, (CZB medium), significantly improved the development of embryos with more than 50% of zygotes from blocking strains (randombred) reaching the blastocyst stage. By using reciprocal crosses between blocking and non-blocking strains it was shown that the maternal genome is mainly responsible for the "2-cell block". As regards media constituents it was found that EDTA was essential for the 1-cell embryo to pass the 2-cell block. Glutamine, in general, did not exert a major effect upon development of mouse zygotes but appeared to benefit development at early stages. Glucose was necessary for successful development of embryos at least from the post-block stages and had no detrimental effects when added from the commencement of culture. Subsequent studies were undertaken to investigate the metabolism of glutamine and glucose by in vivo and in vitro derived mouse embryos. The data showed that glutamine can be utilized catabolically as an energy source by oxidation to CO2. Embryos from the blocking strain metabolised significantly less glutamine than did those from the non-blocking strain but glucose metabolism was similar between the embryos from the two strains, suggesting that strain differences in embryonic development in vitro may be related to the metabolism of glutamine rather than glucose. Finally, a study of glutamine utilization and its reciprocal relationship with glucose by the sheep conceptus was undertaken. These experiments showed that, as found in the mouse, glutamine can be substantially utilized by the conceptus via oxidation to CO2 through the TCA cycle. However, there was increasing preferential utilization of glucose for energy metabolism with development from the cleaving embryo through to the day 19 conceptus.
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Schliffka, Markus. "Multiscale study of mouse preimplantation morphogenesis." Electronic Thesis or Diss., Université Paris sciences et lettres, 2023. http://www.theses.fr/2023UPSLS021.

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Au cours du développement embryonnaire, les animaux suivent une séquence complexe de changements de forme provoqués par des forces issues de la contractilé cellulaire, générées par le cytosquelette de l’actomyosine. Chez l’embryon de mammifère, la morphogenèse débute dès la phase préimplantatoire, qui commence par la fécondation et aboutit à la formation du blastocyste, la structure qui s’implante dans l’utérus maternel. Ainsi, l’embryon préimplantatoire suit une série de mouvements morphogénétiques contrôlés par la contractilité qui aboutissent avec la formation du premier lumen au sein du blastocyste.Nous avons mené la première étude examinant l’effet de la perte complète de contractilité sur le développement préimplantatoire. Nous avons généré les mutants maternels-zygotiques simples et double des gènes Myh9 et Myh10, codants pour les chaînes lourdes de la myosine non musculaire de type II, ce qui nous a permis d’étudier la contribution relative de ces deux paralogues dans la génération de la contractilité cellulaire. Nous avons constaté que Myh9 est le principal contributeur dans ce processus, car sa perte entraîne un retard du cycle cellulaire, une réduction du nombre de cellules, de la compaction et de la différenciation. La perte de Myh10 n’a pas d’impact fort par rapport aux embryons de type sauvage. Néanmoins, un phénotype plus sévère a pu être observé chez les embryons double mutants dont la cytocinèse échoue dans la plupart des cas, suggérant une compensation par Myh10 dans les mutants Myh9. Malgré le manque de cellules, la différenciation et la formation du lumen se poursuivent dans les double mutants. Dans les cas les plus extrêmes, des embryons composés d’une seule et unique cellule accumulent du fluide dans des compartiments intracellulaires, ce qui indique que le programme préimplantatoire est exécuté indépendamment du nombre de cellules.Dans les embryons sauvages, le blastocyste se forme suivant un processus de fracturation hydraulique produisant un réseau de microlumens qui murit en un lumen unique entourée de plusieurs cellules. Bien que le mécanisme global de ce processus soit compris, on ne sait toujours pas comment les cellules régulent localement la dynamique des microlumens. Ici, nous décrivons des blebs inversés aux contacts entre cellules. Les blebs inversés sont des invaginations membranaires de courte durée qui gonflent dans le cytoplasme avant d’être repoussées par la contractilité cellulaire. Les blebs inversés se forment à la suite de l’augmentation globale de la pression du fluide intercellulaire et du confinement local du fluide par l’adhésion cellulaire. Nous proposons que les blebs inversés agissent comme des pompes hydrauliques pour diriger le fluide au sein du réseau de microlumens, promouvant ainsi son murissement.Ces résultats approfondissent notre compréhension moléculaire, cellulaire et biophysique de la façon dont la contractilité cellulaire façonne l’embryon de mammifère
During development, embryos undergo a complex sequence of morphogenetic shape changes powered by cellular contractile forces which allow the embryo to correctly form tissues and organs. Contractile cellular forces in morphogenesis are chiefly generated by the actomyosin cytoskeleton. In the mammalian embryo, morphogenesis begins during preimplantation development, which commences with fertilization and leads up to the formation of the blastocyst, the structure that implants into the maternal uterus. During preimplantation development, the embryo undergoes a series of contractility-driven morphogenetic steps that culminate in the positioning of the first lumen of development in the blastocyst.Here, we conducted the first study investigating the effect of complete contractility loss on preimplantation development. We performed single and double maternal-zygotic knockout of the non-muscle myosin heavy chain genes Myh9 and Myh10, which allowed us to study the relative contribution of these two paralogs to contractility generation in preimplantation development. We found that Myh9 is the main contributor in this process, as its maternal-zygotic loss results in cell cycle delay, reduced cell number, compaction and differentiation. Loss of Myh10 did not have a strong detectable impact compared to wildtype embryos. Nevertheless, a more severe phenotype could be observed in Myh9 and Myh10 double knockout embryos as cytokinesis failed in most cases, suggesting some compensation by Myh10 in Myh9 single mutants. Despite severely reduced cell number, differentiation and lumen formation still somehow continued in double knockout embryos. In the most extreme cases, single-celled embryos accumulated fluid in intracellular compartments, indicating that the preimplantation developmental program is executed independently of cell number.In WT embryos, the blastocyst forms in a process of hydraulic fracturing producing hundreds of microlumen followed by their coarsening into a single lumen surrounded by multiple cells. While the global mechanism of this process is understood, it remains unclear how cells regulate microlumen dynamics locally. Here, we describe inverse blebs at cell-cell contacts during microlumen formation. Inverse blebs are short-lived membrane protrusions expanding into the cytoplasm before being retracted by actomyosin contraction. We show that inverse blebs form due to a global increase in intercellular fluid pressure and require local fluid confinement by cell-cell adhesion. We propose that inverse blebs serve as hydraulic pumps to push the fluid within the microlumen network, thereby supporting the coarsening of the first mammalian lumen.Together, these finding expand our molecular, cellular and physical understanding of how cell contractility shapes the early mammalian embryo
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Byrne, Annette Therese. "Analysis of apoptosis in the preimplantation mammalian embryo." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310908.

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Thomas, Fay Christina. "Tight junction biogenesis in the mouse preimplantation embryo." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270661.

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Boskovic, Ana. "Study of histone variants and chromatin dynamics in the preimplantation mouse embryo." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ034/document.

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Comment le zygote acquiert la totipotence à partir de deux cellules complètement différenciées, et comment les décisions du destin cellulaire sont faites plus tard dans le développement sont des questions biologiques essentielles. Les études menées au cours de la première partie de mon doctorat ont contribué à l'annotation de la composition de la chromatine embryonnaire en ce qui concerne les variantes des histones et des modifications post-traductionnelles. L'expression ectopique de H2A.Z après la fécondation réduit la progression du développement, ce qui suggère que l'absence de H2A.Z au début du développement pourrait être importante pour l'organisation de la chromatine embryonnaire nouvellement formée. Deuxièmement, j'ai étudié la dynamique des histones dans l'embryon de souris en développement. La reprogrammation épigénétique après la fécondation est accompagnée par une étonnante forte mobilité des histones dans le noyau. Ma thèse a contribué à la compréhension des événements dynamiques affectant la chromatine embryonnaire pendant le remodelage épigénétique après la fécondation
How the zygote acquires totipotency from two differentiated cells, and how cell fate decisions are made later in development is a pivotal biological question. The studies conducted during the first part of my doctorate contributed to the annotation of embryonic chromatin composition with regards to histone variants and PTMs, and more specifically those correlated with active chromatin regions. The histone variant H2A.Z was shown to be present on embryonic chromatin in a stage-specific manner. Ectopic expression of H2A.Z after fertilization reduced developmental progression, suggesting that absence of H2A.Z at the onset of development might be important for the organization of the newly formed embryonic chromatin. Secondly, I investigated histone dynamics in the developing mouse embryo. Our work represents the first report on histone mobility during early mouse embryogenesis. My thesis contributed to the understanding of the dynamic events affecting embryonic chromatin during epigenetic remodeling after fertilization
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Books on the topic "Preimplantation embryo"

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Bavister, Barry D., ed. Preimplantation Embryo Development. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7.

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D, Bavister Barry, Serono Symposia USA, and Symposium on Preimplantation Embryo Development (1991 : Newton, Mass.), eds. Preimplantation embryo development. New York: Springer-Verlag, 1993.

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Bavister, Barry D., ed. The Mammalian Preimplantation Embryo. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5332-4.

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Kollek, Regine. Präimplantationsdiagnostik: Embryonenselektion, weibliche Autonomie und Recht. Tübingen: Francke, 2000.

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1943-, Bavister Barry D., ed. The Mammalian preimplantation embryo: Regulation ofgrowth and differentiation in Vitro. New York: Plenum, 1987.

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Gounalakis, Georgios. Embryonenforschung und Menschenwürde. Baden-Baden: Nomos, 2006.

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D, Bavister Barry, ed. The Mammalian preimplantation embryo: Regulation of growth and differentiation in vitro. New York: Plenum Press, 1987.

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1932-, Yoshinaga Koji, Mori Takahide 1933-, and International Congress of Endocrinology (8th : 1988 : Kyoto, Japan), eds. Development of preimplantation embryos and their environment: Proceedings of a Symposium on Development of Preimplantation Embryos and their Environment (satellite symposium of the 8th International Congress of Endocrinology), held in Kyoto, Japan, July 14-16, 1988. New York: A.R. Liss, 1989.

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Klekamp, Mareike. Lücken im Lebensschutz: Humane Vorkernstadien und Präimplantationsdiagnostik aus der Sicht der christlichen Gesellschaftslehre. Paderborn: F. Schöningh, 2008.

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Gardner, David K., Denny Sakkas, Emre Seli, and Dagan Wells, eds. Human Gametes and Preimplantation Embryos. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6651-2.

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Book chapters on the topic "Preimplantation embryo"

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Albertini, David F., Dineli Wickramasinghe, Susan Messinger, Britta A. Mattson, and Carlos E. Plancha. "Nuclear and Cytoplasmic Changes During Oocyte Maturation." In Preimplantation Embryo Development, 3–21. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_1.

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Magnuson, Terry, Shyam K. Sharan, and Bernadette Holdener-Kenny. "Mutations Affecting Early Development in the Mouse." In Preimplantation Embryo Development, 131–43. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_10.

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Ferguson-Smith, Anne C., and M. Azim Surani. "Parental Imprinting in Mammalian Development." In Preimplantation Embryo Development, 144–56. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_11.

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Rossant, Janet, Elizabeth Merentes-Diaz, Elen Gocza, Eszter Ivanyi, and Andras Nagy. "Developmental Potential of Mouse Embryonic Stem Cells." In Preimplantation Embryo Development, 157–65. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_12.

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Kane, M. T., and M. M. Fahy. "Blastocyst Development and Growth: Role of Inositol and Citrate." In Preimplantation Embryo Development, 169–83. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_13.

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Hardy, Kate. "Development of Human Blastocysts In Vitro." In Preimplantation Embryo Development, 184–99. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_14.

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Gardiner, Catherine S., and Alfred R. Menino. "Development of Na/K ATPase Activity and Blastocoel Formation." In Preimplantation Embryo Development, 200–210. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_15.

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Pedersen, R. A., K. S. Sturm, D. A. Rappolee, and Z. Werb. "Effects of Imprinting on Early Development of Mouse Embryos." In Preimplantation Embryo Development, 212–26. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_16.

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Roberts, R. Michael, William E. Trout, Nagappan Mathialagan, Melody Stallings-Mann, and Ping Ling. "Uterine Secretory Activity and Embryo Development." In Preimplantation Embryo Development, 229–43. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_17.

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Kimber, S. J., R. Waterhouse, and S. Lindenberg. "In Vitro Models for Implantation of the Mammalian Embryo." In Preimplantation Embryo Development, 244–63. New York, NY: Springer New York, 1993. http://dx.doi.org/10.1007/978-1-4613-9317-7_18.

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Conference papers on the topic "Preimplantation embryo"

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Karmenyan, Artashes, Yury Kistenev, Elena Perevedentseva, Alexander Krivokharchenko, Micahella Sarmiento, Eviyona L. Barus, Chia-Liang Cheng, and Denis A. Vrazhnov. "Machine learning methods for the in-vitro analysis of preimplantation embryo Raman micro-spectroscopy." In Fourth International Conference on Terahertz and Microwave Radiation: Generation, Detection, and Applications, edited by Oleg A. Romanovskii and Yurii V. Kistenev. SPIE, 2020. http://dx.doi.org/10.1117/12.2580485.

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Gendi Song, Baoguo Chai, Chunli Li, Zhenyu Zheng, and Weidong Zhao. "The expression of reference genes affecting preimplantation mouse embryo death in the DDK syndrome." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5966296.

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Anh, Huynh Nguyen Loan, Pham Truong Duy, Huynh Thi Thao Nguyen, Ngo Thi Kim Anh, Pham Phuong An, Bui Hong Thuy, and Nguyen Van Thuan. "EVALUATION OF DEVELOPMENTAL CHARACTERISTICS OF SINGLE BLASTOMERE BIOPSIED FROM 8-CELL MOUSE EMBRYO DURING PREIMPLANTATION DEVELOPMENT." In NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM - BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM. Nhà xuất bản Khoa học tự nhiên và Công nghệ, 2022. http://dx.doi.org/10.15625/vap.2022.0070.

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Omelchenko, A. N., K. A. Okotrub, N. V. Surovtsev, T. N. Igonina, E. Yu Brusentsev, and S. Y. Amstislavsky. "APPLICATION OF RAMAN SPECTROSCOPY TO THE CHARACTERIZATION OF THE METABOLISM OF MOUSE PREIMPLANTATION EMBRYOS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-200.

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The research demonstrates the description of the metabolism of mouse preimplantation embryos by Raman spectroscopy using deuterated labels. We observe changes in the transport of fatty acids (stearic acid), amino acids (phenylalanine and leucine) and glucose after embryos cryopreservation.
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Burton, Jason C., Shang Wang, and Irina V. Larina. "Dynamic imaging of preimplantation embryos in the murine oviduct." In SPIE BiOS, edited by Andrew M. Rollins, Scott E. Fraser, and Michael A. Choma. SPIE, 2015. http://dx.doi.org/10.1117/12.2079913.

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Ivanova, A. D., M. A. Tofilo, and I. V. Volodyaev. "FALSE POSITIVE DIAGNOSIS OF CHROMOSOMAL MOSAICISM IN IVF: FACTORS OF INFLUENCE." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.163-170.

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The article discusses the influence of laboratory factors on the occurrence of artifact noise on NGS profiles, which can be falsely interpreted as chromosomal mosaicism of preimplantation embryos in IVF clinical practice.
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Yu-Hsiang Chung, Yi-Hsing Hsiao, Chia-Hsien Hsu, and Chihchen Chen. "Effects of culture medium and volume on preimplantation development of mouse embryos." In 2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2015. http://dx.doi.org/10.1109/nano.2015.7388750.

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Hieu, Giang Trung, Pham Truong Duy, Mai Thi Quynh Nhu, Tran Le Quy, Nguyen Hoang Bao Ngan, Lac Duong Hung, Bui Hong Thuy, and Nguyen Van Thuan. "EFFECT OF CUMULUS CELL CO-CULTURED ON PREIMPLANTATION DEVELOPMENT OF CLONED BOVINE EMBRYOS." In NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM - BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM. Nhà xuất bản Khoa học tự nhiên và Công nghệ, 2022. http://dx.doi.org/10.15625/vap.2022.0065.

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Ilina, Inna V., Yulia V. Khramova, Maxim A. Filatov, and Dmitry S. Sitnikov. "Noncontact tagging and identification of preimplantation mammalian embryos by means of ultrafast laser microsurgery." In Translation of Lasers and Biophotonics Technologies and Procedures: Toward the Clinic, edited by Lothar D. Lilge and Carsten M. Philipp. SPIE, 2019. http://dx.doi.org/10.1117/12.2526838.

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Tan, Do Minh, Nguyen Mai Phuong, Cao Hoang Nam, Nguyen Tuan Anh, Nguyen Huu Hoang Minh, Pham Minh Chien, Pham Quoc Dinh, and Nguyen Van Thuan. "THE EFFECT OF HISTONE DEACETYLATION INHIBITORS (HDACI) TREATMENT DURING ZYGOTIC GENE ACTIVATION ON PREIMPLANTATION DEVELOPMENT OF CLONED BOVINE EMBRYOS." In NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM - BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM. Nhà xuất bản Khoa học tự nhiên và Công nghệ, 2022. http://dx.doi.org/10.15625/vap.2022.0095.

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Reports on the topic "Preimplantation embryo"

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Ingilizova, Gergana, Ivan Kostov, Emil Kovachev, Viktoria Necheva, and Svetlozar Slavov. Preimplantation Embryo Quality in Patients with Low Ovarian Reserve: Study of 72 IVF/ICSI Treatment Cycles. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, August 2020. http://dx.doi.org/10.7546/crabs.2020.08.14.

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