Relevant bibliographies by topics / Pregnenolone

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
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Academic literature on the topic 'Pregnenolone'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Pregnenolone"

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Gao, Huaze, Zachary Magin, Nia Fogelman, Rajita Sinha, Gustavo A. Angarita, and Verica Milivojevic. "Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings." Life 14, no. 11 (2024): 1483. http://dx.doi.org/10.3390/life14111483.

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Substance use disorders (SUDs), including cocaine use disorder (CUD), have significant negative health risks and impose a substantial social burden, yet effective treatments are limited. Pregnenolone, a neuroactive steroid precursor, has been shown to reduce alcohol craving and normalize stress biology in individuals with CUD, but its clinical utility has been questioned due to limited data on bioavailability and the stability of blood levels in humans. Thus, this pilot study aimed to determine whether twice-daily oral pregnenolone (PREG) at 300 mg/day and 500 mg/day versus placebo in week two
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McKay, S. A., G. Jenkin та G. D. Thorburn. "Peripheral plasma concentrations of pregnenolone sulphate, pregnenolone, progesterone and 20α-hydroxy-4-pregnen-3-one in ewes throughout the oestrous cycle". Journal of Endocrinology 113, № 2 (1987): 231–37. http://dx.doi.org/10.1677/joe.0.1130231.

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ABSTRACT Pregnenolone sulphate, pregnenolone, progesterone and 20α-hydroxy-4-pregnen-3-one concentrations in peripheral plasma of normal cyclic ewes were measured by radioimmunoassay. The concentrations of these steroids were correlated with that of progesterone. The concentrations of all the steroids measured in peripheral plasma varied in a cyclic manner and showed a significant (P <0·05) positive correlation with the concentration of progesterone. Peripheral plasma concentrations of these steroids in ovariectomized and ovariectomized, dexamethasone-treated ewes were also determined. The
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Tsang, Benjamin K., David F. Mattice, Ming Li, and Elikplimi K. Asem. "Effect of calcium ionophore A23187 on pregnenolone metabolism to progesterone in rat granulosa cells." Canadian Journal of Physiology and Pharmacology 66, no. 7 (1988): 960–63. http://dx.doi.org/10.1139/y88-157.

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The effect of calcium ionophore A23187 on the metabolism of pregnenolone to progesterone was examined in rat granulosa cells during a 24-h culture period. Granulosa cells harvested from pregnant mare's serum gonadotropin treated immature rats were incubated in the presence and absence of the divalent cation ionophore A23187. The ionophore induced progesterone synthesis from both endogenous sterol substrate and exogenous pregnenolone in a time- and concentration-dependent manner. Pregnenolone metabolism was examined in the presence of aminoglutethimide phosphate, an inhibitor of endogenous preg
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Morsy, Mohamed A., Seham A. Abdel-Gaber, Sahar A. Mokhemer, et al. "Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1." Pharmaceuticals 16, no. 5 (2023): 665. http://dx.doi.org/10.3390/ph16050665.

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The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the cardioprotective potential of pregnenolone against DOX-induced cardiotoxicity. After acclimatization, male Wistar rats were randomly grouped into four groups: control (vehicle-treated), pregnenolone (35 mg/kg/d, p.o.), DOX (15 mg/kg, i.p, once), and pregnenolone + DOX. All treatments continued for seven consecutive days except DOX, which was administe
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Jiang, Jingjing, Xue Liu, Xiaotian Liu, et al. "The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose–response analysis from Henan Rural Cohort." European Journal of Endocrinology 181, no. 6 (2019): 603–14. http://dx.doi.org/10.1530/eje-19-0352.

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Objective Previous studies have uncovered a progestin-only contraceptive association with an increased risk of diabetes, but limited studies have explored the relationship of endogenous progesterone and pregnenolone levels with diabetes status. A case–control study was conducted in Henan Rural Cohort (register number: ChiCTR-OOC-15006699) to evaluate the dose–response independent and interactive relationship of progesterone and pregnenolone levels with prediabetes and type 2 diabetes mellitus (T2DM) in Chinese rural population. Design A case-control study. Methods A total of 798 T2DM patients,
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Legacki, Erin L., Barry A. Ball, C. Jo Corbin, et al. "Equine fetal adrenal, gonadal and placental steroidogenesis." Reproduction 154, no. 4 (2017): 445–54. http://dx.doi.org/10.1530/rep-17-0239.

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Equine fetuses have substantial circulating pregnenolone concentrations and thus have been postulated to provide significant substrate for placental 5α-reduced pregnane production, but the fetal site of pregnenolone synthesis remains unclear. The current studies investigated steroid concentrations in blood, adrenal glands, gonads and placenta from fetuses (4, 6, 9 and 10 months of gestational age (GA)), as well as tissue steroidogenic enzyme transcript levels. Pregnenolone and dehydroepiandrosterone (DHEA) were the most abundant steroids in fetal blood, pregnenolone was consistently higher but
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Costa, Barbara, Stefano Pini, Pamela Gabelloni, et al. "The Spontaneous Ala147Thr Amino Acid Substitution within the Translocator Protein Influences Pregnenolone Production in Lymphomonocytes of Healthy Individuals." Endocrinology 150, no. 12 (2009): 5438–45. http://dx.doi.org/10.1210/en.2009-0752.

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Abstract The de novo production of steroids and neurosteroids begins in mitochondria by the conversion of cholesterol to pregnenolone through cytochrome P450 side-chain cleavage (CYP11A1) enzymatic activity. The C-terminal amino acid domain of the translocator protein (TSPO) has been demonstrated to bind cholesterol, thereby determining its mitochondrial translocation. The goal of the present study was to investigate the effect of the Ala147Thr single-nucleotide polymorphism localized in this TSPO region on pregnenolone production in healthy volunteers. Pregnenolone production was evaluated in
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Vallée, Monique, Sergio Vitiello, Luigi Bellocchio, et al. "Pregnenolone Can Protect the Brain from Cannabis Intoxication." Science 343, no. 6166 (2014): 94–98. http://dx.doi.org/10.1126/science.1243985.

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Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop prot
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French, Joseph T., and Thomas H. Welsh. "In vitro modulation of porcine Leydig cell steroidogenesis by phorbol-12-myristate-13-acetate and 1,2-dioctanoylglycerol." Acta Endocrinologica 122, no. 1 (1990): 101–6. http://dx.doi.org/10.1530/acta.0.1220101.

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Abstract Serum-free primary cultures of neonatal (1-day-old) porcine Leydig cells were used to study the effects of phorbol-12-myristate-13-acetate and 1,2-dioctanoylglycerol on testosterone and pregnenolone production. Phorbol-12-myristate-13-acetate alone from 0.001-10 μmol/l stimulated testosterone and pregnenolone production, whereas 1,2-dioctanoylglycerol alone had no effect on steroid production, relative to control. Phorbol12-myristate-13-acetate and 1,2-dioctanoylglycerol each inhibited pLH-stimulated testosterone and pregnenolone production. To further clarify the influence of these p
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Bracci, Massimo, Laura Zingaretti, Margherita Martelli, et al. "Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 3195. http://dx.doi.org/10.3390/ijerph20043195.

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Steroid hormone levels are closely related to the endogenous circadian rhythm induced by sleep–wake and dark–light cycles. Shift work that disrupts the circadian rhythm may influence the levels of steroid hormones. The association between shift work and alterations in female sex steroid hormone levels has been studied, but little is known about testosterone and its precursor pregnenolone levels in male shift workers. The present study investigated serum pregnenolone and testosterone levels in a group of shift and daytime male workers. All participants were sampled at the beginning of the morni
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Dissertations / Theses on the topic "Pregnenolone"

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Sowa, Calan B. "The role of pregnenolone sulfate in modulating neuronal excitability." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12230.

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Thesis (M.A.)--Boston University<br>The central nervous system operates through a tightly balanced relationship of excitatory and inhibitory synaptic transmission. Neurosteroids, synthesized de novo from cholesterol in the human brain as well as converted from precursors circulating in the blood, are proven modulators of this synaptic activity. Pregnenolone sulfate, one of the most abundant endogenous neurosteroids, is a negative modulator of the GABA receptor and positive modulator of NMDA and AMPA receptors, increasing the frequency of excitatory transmission in the brain. Here, we show that
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Darnaudéry, Muriel. "Sulfate de pregnenolone et mémoire : aspects comportementaux, neurochimiques et électroencéphalographiques." Bordeaux 2, 1998. http://www.theses.fr/1998BOR28608.

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Sano(Hamasaki), Mayumi. "Pregnenoloneは分裂期のcentriole engagementを制御する". 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/195989.

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HU, ZHONG YI. "Neurosteroides : biosynthese et metabolisme de la pregnenolone dans les oligodendrocytes du cerveau de rat." Paris 6, 1989. http://www.theses.fr/1989PA066248.

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Les mitochondries d'oligodendrocytes de rats ages de 3 semaines transforment le #3h-cholesterol en #3h-pregnenolone(p), en #3h-pregn-5-ene-3 beta, 20 alpha-diol (20-oh-p). Les cultures primaires de cellules gliales de rats nouveaux-nes contiennent 60% d'oligodendrocytes, comme indique par la detection immunocytochimique au galactocerebroside, les oligodendrocytes contiennent aussi un antigene reconnu par des igg anti-p450scc, ces cultures primaires convertissent le #3h-mevolonolactone (mva) en #3h-cholesterol(c), en #3h-p et en #3h-20-oh-p. Les oligodendrocytes subissent un processus de differ
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Tomaselli, Giovanni. "Role of pregnenolone derivative AEF0117 on the regulation of CB1 signaling that mediates behavioral effects of THC." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0122.

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Le cannabis sativa est l'une des drogues les plus consommées dans le monde. Le THC, sa principale composante psychoactive, représente un facteur de risque de pathologies mentales, telles que le trouble de la consommation de cannabis, la dépendance et la psychose. Le THC a un effet biphasique, de fortes doses de THC provoquent une hypoactivité et une aversion, tandis que de faibles doses de THC provoquent une hyperactivité et une récompense. Le THC agit sur le récepteur aux cannabinoïdes de type 1 (CB1), dont la signalisation est biaisée avec différents transducteurs pouvant véhiculer une voie
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Urs, Aarti N. "Reciprocal binding of sphingosine and phosphatidic acid to steroidogenic factor 1 regulates the transcription of CYP17." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11212005-102620/.

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Thesis (M. S.)--Biology, Georgia Institute of Technology, 2006.<br>Donald Doyle, Committee Member ; Harish Radhakrishna, Committee Member ; Alfred Merrill, Committee Member ; Marion Sewer, Committee Chair Includes bibliographical references.
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Cox, Michele Margaret Freedman William McElligott James G. "The effects of a neurosteroid, pregnenolone sulfate, in the cerebellum on vestibulo-ocular reflex adaptation (VOR) in goldfish /." Philadelphia, Pa. : Drexel University, 2006. http://hdl.handle.net/1860/1119.

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Whang, Daniel. "Regulation of 7 alpha-hydroxylation of dehydroepiandrosterone and pregnenolone in human adipose stromal cells, mechanistic and expression studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq30833.pdf.

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Young, Jacques. "Les neurosteroides chez le rat et la souris : correlations fonctionnelles." Paris 11, 1996. http://www.theses.fr/1996PA11T006.

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Rouiller-Fabre, Virginie. "Production de pregnenolone et de progesterone par l'ovaire foetal de rat in vitro : ontogenese et regulation des activites enzymatiques." Paris 6, 1989. http://www.theses.fr/1989PA066436.

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Classiquement, il est admis depuis de nombreuses annees que l'ovaire ftal de mammifere ne possede pas d'activite staroidogene alors que, au meme moment, chez le male, une synthese de testosterone apparait. Le but de notre travail a ete de rechercher chez le rat les etapes limitantes de la steroidogenese ovarienne, au cours de la vie ftale. Nous avons etudie les deux etapes conduisant a la production de progesterone. Dans une premiere serie d'experiences, nous avons suivi, par dosage radioimmunologique, la production de pregnenolone et de progesterone d'ovaires ftaux de 18,5 j. P. C. Explantes
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Books on the topic "Pregnenolone"

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Dolby, Victoria. Pregnenolone. McGraw-Hill, 1999.

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Pregnenolone: Nature's feel good hormone. Avery Pub. Group, 1997.

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Pregnenolone: The Ultimate Hormone Precursor (Woodland Health). Woodland Publishing, 1997.

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Pregnenolone: A Radical New Approach to Health, Longevity, and Emotional Well-Being. Essential Science Publishing, 2000.

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Mahler, Philip. Longitudinalverlauf von Pregeneolon und 17-OH Pregnenolon bei Früh- und Neugeborenen in der Neonatalperiode. 2004.

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Book chapters on the topic "Pregnenolone"

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Bährle-Rapp, Marina. "Pregnenolone Acetate." In Springer Lexikon Kosmetik und Körperpflege. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8482.

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Sih, Rakhmawati, Hosam Kamel, Mohamad Horani, and John E. Morley. "Dehydroepiandrosterone and Pregnenolone." In Hormone Replacement Therapy. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-700-0_15.

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Tariq, Syed H., Hosam Kamel, and John E. Morley. "Dehydroepiandrosterone and Pregnenolone." In Endocrine Replacement Therapy in Clinical Practice. Humana Press, 2003. https://doi.org/10.1007/978-1-59259-375-0_18.

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Ritsner, Michael S., Anatoly Gibel, Yael Ratner, and Abraham Weizman. "Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia." In Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6854-6_14.

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Baulieu, Etienne-Emile, Paul Robel, Oliver Vatier, Marc Haug, Claude Le Goascogne, and Eliane Bourreau. "Neurosteroids: Pregnenolone and Dehydroepiandrosterone in the Brain." In Receptor-Receptor Interactions. Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-08949-9_9.

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Baulieu, Etienne-Emile, Paul Robel, Oliver Vatier, Marc Haug, Claude Le Goascogne, and Eliane Bourreau. "Neurosteroids: Pregnenolone and Dehydroepiandrosterone in the Brain." In Receptor-Receptor Interactions. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5415-4_9.

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Roberts, Eugene. "Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-Like Sensitivity." In Neurosteroids. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-59259-693-5_19.

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Payne, Victoria M., Jason D. Kilts, Jennifer C. Naylor, et al. "Allopregnanolone and Pregnenolone Alterations Following Pharmacological Agents in Rodents and Clinic Populations." In Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6854-6_18.

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Wakerley, J. B., and C. M. Richardson. "Differential Effects of the Neurosteroid Pregnenolone Sulphate on Oxytocin and Vasopressin Neurones in Vitro." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4871-3_13.

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Brewster, M. E., W. R. Anderson, T. Loftsson, N. Bodor, and E. Popa. "Effect of 2-Hydroxypropyl-β-Cyclodextrin Complexes of the Neurosteroids, Alfaxalone, Pregnanolone and Pregnenolone, on Various Convulsant Stimuli in the Mouse." In Proceedings of the Eighth International Symposium on Cyclodextrins. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_113.

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Conference papers on the topic "Pregnenolone"

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Zahari, Noor Fazila, and Ikram M. Said. "Pregnenolone from the roots of Holarrhena curtisii." In THE 2013 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2013 Postgraduate Colloquium. AIP Publishing LLC, 2013. http://dx.doi.org/10.1063/1.4858747.

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Eldeeb, Khalil, Allyn C. Howlett, Victor M. Pulgar, et al. "Diphenylpyraline derivative JKH10 behaves as a CB1 receptor agonist and docks at cholesterol and pregnenolone binding sites." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.568.130969.

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Bilan, Dmitri, Sergiu Cojocari, Natalia Sucman, Eughenia Stingaci, and Fliur Macaev. "Transforming the five-membered ring d in a pregnenolone derivative into a six-membered ring through skeletal rearrangement." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab22.

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In pursuit of obtaining steroid derivatives containing a triazole moiety in their structure, a series of reactions was conducted (Figure 1). In these reactions, an intermediate compound was the corresponding azide 3, which was subsequently involved in a reaction with the required alkyne to form a 1,2,3-triazole. In click chemistry reactions, it is well-known that catalysts are one-valent copper salts, which can be generated in situ from copper(II) salts. However, the NMR spectra of the main product, isolated from the reaction mass, did not match the expected results.Figure 1. The procedure for
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Reports on the topic "Pregnenolone"

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Meidan, Rina, and Robert Milvae. Regulation of Bovine Corpus Luteum Function. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604935.bard.

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The main goal of this research plan was to elucidate regulatory mechanisms controlling the development, function of the bovine corpus luteum (CL). The CL contains two different sterodigenic cell types and therefore it was necessary to obtain pure cell population. A system was developed in which granulosa and theca interna cells, isolated from a preovulatory follicle, acquired characteristics typical of large (LL) and small (SL) luteal cells, respectively, as judged by several biochemical and morphological criteria. Experiments were conducted to determine the effects of granulosa cells removal
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