Journal articles on the topic 'Pregnancy outcome predictors'
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Sinyakova, Anna A., Elena V. Shipitsyna, Olga V. Budilovskaya, Vyacheslav M. Bolotskikh, and Alevtina M. Savicheva. "Anamnestic and microbiological predictors of miscarriage." Journal of obstetrics and women's diseases 68, no. 2 (May 29, 2019): 59–70. http://dx.doi.org/10.17816/jowd68259-70.
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Hypothesis/aims of study. Miscarriage is a significant medical and social problem. The etiology of pregnancy losses is diverse and depends on many factors. It is believed that dysbiotic disorders of the vagina are one of the main causes of this pathology. While the etiopathogenesis of miscarriage is actively studied, many questions still remain open. The aim of the study was to investigate anamnestic and microbiological predictor factors of miscarriage.
Study design, materials, and methods. In a prospective cohort study, 159 pregnant women were examined in the first trimester of pregnancy: the anamnesis, course of pregnancy, vaginal microflora, and present pregnancy outcome were studied. The vaginal microflora was analyzed using microscopic, bacteriological and quantitative real-time PCR methods. Depending on the present pregnancy outcome, the patients were divided into two groups: those delivered at term and women with early and late miscarriage. The analysis of predictors of miscarriage of the ongoing pregnancy was performed depending on the period of delivery.
Results. The rate of miscarriage in women was 13%. The independent predictors of early miscarriage were chronic endometritis (OR 10.54; 95% CI 2.54 to 43.64), the dominance of Lactobacillus iners in the vaginal microflora (OR 8.52; 95% CI 2.07 to 35.05), and the prevalence of non-Lactobacillus species in microscopy of vaginal preparations (OR 4.50; 95% CI 1.02 to 19.69). The dominance of Lactobacillus crispatus was a significant protective factor of late miscarriage (OR 0.20; 95% CI 0.04 to 0.99).
Conclusion. The undertaken analysis revealed significant associations of a number of anamnestic and microbiological predictor factors with miscarriage, which will enable to substantiate approaches for predicting pregnancy outcomes at different gestational age and to develop methods of pre-conception care and treatment in women with different risk of miscarriage.
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Burgoyne, M., R. Clouston, A. Banerjee, J. Fraser, and P. Atkinson. "LO01: What presenting features predict obstetrical outcomes in women who present to the emergency department with early pregnancy bleeding?" CJEM 22, S1 (May 2020): S6—S7. http://dx.doi.org/10.1017/cem.2020.57.
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Introduction: Vaginal bleeding in early pregnancy is a common emergency department (ED) presentation, with many of these episodes resulting in poor obstetrical outcome. These outcomes have been extensively studied, but there have been few evaluations of what variables are associated predictors. This study aimed to identify predictors of less than optimal obstetrical outcomes for women who present to the ED with early pregnancy bleeding. Methods: A regional centre health records review included pregnant females who presented to the ED with vaginal bleeding at <20 weeks gestation. This study investigated differences in presenting features between groups with subsequent optimal outcomes (OO; defined as a full-term live birth >37 weeks) and less than optimal outcomes (LOO; defined as a miscarriage, stillbirth or pre-term live birth). Predictor variables included: maternal age, gestational age at presentation, number of return ED visits, socioeconomic status (SES), gravida-para-abortus status, Rh status, Hgb level and presence of cramping. Rates and results of point of care ultrasound (PoCUS) and ultrasound (US) by radiology were also considered. Results: Records for 422 patients from Jan 2017 to Nov 2018 were screened and 180 patients were included. Overall, 58.3% of study participants had a LOO. The only strong predictor of outcome was seeing an Intra-Uterine Pregnancy (IUP) with Fetal Heart Beat (FHB) on US; OO rate 74.3% (95% CI 59.8-88.7; p < 0.01). Cramping (with bleeding) trended towards a higher rate of LOO (62.7%, 95% CI 54.2-71.1; p = 0.07). SES was not a reliable predictor of LOO, with similar clinical outcome rates above and below the poverty line (57.5% [95% CI 46.7-68.3] vs 59% [95% CI 49.3-68.6] LOO). For anemic patients, the non-live birth rate was 100%, but the number with this variable was small (n = 5). Return visits (58.3%, 95% CI 42.2-74.4), previous abortion (58.8%, 95% CI 49.7-67.8), no living children (60.2%, 95% CI 50.7-69.6) and past pregnancy (55.9%, 95% CI 46.6-65.1) were not associated with higher rates of LOO. Conclusion: Identification of a live IUP, anemia, and cramping have potential as predictors of obstetrical outcome in early pregnancy bleeding. This information may provide better guidance for clinical practice and investigations in the emergency department and the predictive value of these variables support more appropriate counseling to this patient population.
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Mujaibel, K., D. Farquharson, and R. D. Wilson. "Predictors of Pregnancy Outcome in Renal transplant Recipients." Journal SOGC 23, no. 10 (October 2001): 939–44. http://dx.doi.org/10.1016/s0849-5831(16)30862-x.
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Lee, G. "OP10.05: Predictors of pregnancy outcome for emergency cerclage." Ultrasound in Obstetrics & Gynecology 46 (September 2015): 81–82. http://dx.doi.org/10.1002/uog.15193.
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Umarsingh, Shalini, Jamila Khatoon Adam, and Suresh Babu Naidu Krishna. "The relationship between anti-Müllerian hormone (AMH) levels and pregnancy outcomes in patients undergoing assisted reproductive techniques (ART)." PeerJ 8 (December 22, 2020): e10390. http://dx.doi.org/10.7717/peerj.10390.
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A variety of predictors are available for ovarian stimulation cycles in assisted reproductive technology (ART) forecasting ovarian response and reproductive outcome in women including biomarkers such as anti- Müllerian hormone (AMH). The aim of our present study was to compare the relationship between AMH levels and pregnancy outcomes in patients undergoing intra-cytoplasmic sperm injection (ICSI). Overall, fifty patients (n = 50), aged 20–45 years were recruited for the present prospective study. Three AMH levels were presented with high often poly cystic ovarian syndrome (PCOS) amongst 52.4% patients, 40.5% in normal and 7.1% in low to normal, correspondingly. There was statistically significant relationship between AMH and day of embryo transfer (p < 0.05). The Pearson analysis between AMH, age, E2 and FSH displayed no statistically significant relationship between E2 and AMH (p < 0.05) and negative correlation between FSH and age (p > 0.05). The area under the receiver operating characteristic curve for E2 was 0.725 and for AMH levels as predictors of CPR was 0.497 indicating E2 as better predictor than AMH. The number of oocytes, mature oocytes and fertilized oocytes all presented a weak positive relationship to AMH. Our results confirm the clinical significance of AMH to accurately predict ovarian reserve as a marker and its limitations to use as predictor for a positive pregnancy outcome. Additional prospective studies should be conducted to validate the predictive capability of AMH levels for the outcome of clinical pregnancy.
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De Carolis, Sara, Angela Botta, Stefania Santucci, Serafina Garofalo, Carmelinda Martino, Alessandra Perrelli, Silvia Salvi, Sergio Ferrazzani, Leonardo Caforio, and Giovanni Scambia. "Predictors of Pregnancy Outcome in Antiphospholipid Syndrome: A Review." Clinical Reviews in Allergy & Immunology 38, no. 2-3 (June 27, 2009): 116–24. http://dx.doi.org/10.1007/s12016-009-8144-z.
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Syoum, Fisseha Hailemariam, Girmatsion Fisseha Abreha, Dessalegn Massa Teklemichael, and Mebrahtu Kalayu Chekole. "Fetomaternal Outcomes and Associated Factors among Mothers with Hypertensive Disorders of Pregnancy in Suhul Hospital, Northwest Tigray, Ethiopia." Journal of Pregnancy 2022 (November 9, 2022): 1–9. http://dx.doi.org/10.1155/2022/6917009.
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Background. Hypertensive disorder of pregnancy is the leading cause of maternal and perinatal morbidity and mortality worldwide and the second cause of maternal mortality in Ethiopia. The current study is aimed at assessing fetal-maternal outcomes and associated factors among mothers with hypertensive disorders of pregnancy complication at Suhul General Hospital, Northwest Tigray, Ethiopia, 2019. Methods:A hospital-based cross-sectional study was conducted from Oct. 1st, 2019, to Nov. 30, 2019, at Suhul General Hospital women’s chart assisted from July 1st, 2014, to June 31st, 2019. Charts were reviewed consecutively during five years, and data were collected using data abstraction format after ethical clearance was assured from the Institutional Review Board of Mekelle University College of Health Sciences. Data were entered into Epi-data 3.5.3 and exported to SPSS 22 for analysis. Bivariable and multivariable analyses were done to ascertain fetomaternal outcome predictors. Independent variables with p value < 0.2 for both perinatal and maternal on the bivariable analysis were entered in multivariable logistic regression analysis and the level of significance set at p value < 0.05. Results. Out of 497 women, 328 (66%) of them were from rural districts, the mean age of the women was 25.94 ± 6.46 , and 252 (50.7%) were para-one. The study revealed that 252 (50.3%) newborns of hypertensive mothers ended up with at least low Apgar score 204 (23.1%), low birth weight 183 (20.7%), preterm gestation 183 (20.7%), intensive care unit admissions 90 (10.2%), and 95% CI (46.1% -54.9%), and 267 (53.7%) study mothers also developed maternal complication at 95% (49.3-58.1). Being a teenager ( AOR = 1.815 : 95 % CI = 1.057 − 3.117 ), antepartum-onset hypertensive disorders of pregnancy ( AOR = 7.928 : 95 % CI = 2.967 − 21.183 ), intrapartum-onset hypertensive disorders of pregnancy ( AOR = 4.693 : 95 % CI = 1.633 − 13.488 ), and low hemoglobin level ( AOR = 1.704 : 95 % CI = 1.169 − 2.484 ) were maternal complication predictors; rural residence ( AOR = 1.567 : 95 % CI = 1.100 − 2.429 ), antepartum-onset hypertensive disorders of pregnancy ( AOR = 3.594 : 95 % , CI = 1.334 − 9.685 ), and intrapartum-onset hypertensive disorders of pregnancy ( AOR = 3.856 : 95 % CI = 1.309 − 11.357 ) were predictors of perinatal complications. Conclusions. Hypertensive disorder during pregnancy leads to poor fetomaternal outcomes. Teenage age and hemoglobin levels were predictors of maternal complication. A rural resident was the predictor of poor perinatal outcome. The onset of hypertensive disorders of pregnancy was both maternal and perinatal complication predictors. Quality antenatal care services and good maternal and childcare accompanied by skilled healthcare providers are essential for early detection and management of hypertensive disorder of pregnancy.
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Xie, Xinglei, Jiaming Liu, Isabel Pujol, Alicia López, María José Martínez, Apolonia García-Patterson, Juan M. Adelantado, Gemma Ginovart, and Rosa Corcoy. "Inadequate Weight Gain According to the Institute of Medicine 2009 Guidelines in Women with Gestational Diabetes: Frequency, Clinical Predictors, and the Association with Pregnancy Outcomes." Journal of Clinical Medicine 9, no. 10 (October 18, 2020): 3343. http://dx.doi.org/10.3390/jcm9103343.
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Background: In the care of women with gestational diabetes mellitus (GDM), more attention is put on glycemic control than in factors such as gestational weight gain (GWG). We aimed to evaluate the rate of inadequate GWG in women with GDM, its clinical predictors and the association with pregnancy outcomes. Methods: Cohort retrospective analysis. Outcome variables: GWG according to Institute of Medicine 2009 and 18 pregnancy outcomes. Clinical characteristics were considered both as GWG predictors and as covariates in outcome prediction. Statistics: descriptive, multinomial and logistic regression. Results: We assessed 2842 women diagnosed with GDM in the 1985–2011 period. GWG was insufficient (iGWG) in 50.3%, adequate in 31.6% and excessive (eGWG) in 18.1%; length of follow-up for GDM was positively associated with iGWG. Overall pregnancy outcomes were satisfactory. GWG was associated with pregnancy-induced hypertension, preeclampsia, cesarean delivery and birthweight-related outcomes. Essentially, the direction of the association was towards a higher risk with eGWG and lower risk with iGWG (i.e., with Cesarean delivery and excessive growth). Conclusions: In this cohort of women with GDM, inadequate GWG was very common at the expense of iGWG. The associations with pregnancy outcomes were mainly towards a higher risk with eGWG and lower risk with iGWG.
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Lapshtaeva, A. V., I. V. Sychev, and L. N. Goncharova. "Laboratory predictors of pregnancy in vitro fertilization." Russian Clinical Laboratory Diagnostics 66, no. 5 (May 23, 2021): 291–96. http://dx.doi.org/10.51620/0869-2084-2021-66-5-291-296.
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Identification of factors determining both of favorable and unfavorable outcome of IVF will increase the effectiveness of this method and optimize infertility treatment. The aim of the research is to analyze the correlation between serum IL-1α concentration, its gene rs1800587 (C/T) genotype carrier and thyroid-stimulating hormone (TSH), thyroid hormones (triiodothyronine (T3) and tetraiodothyronine (T4)), and evaluate the prognostic significance of their combinations in women with tube-peritoneal infertility under the IVF program. 120 patients with tube-peritoneal infertility who applied for an IVF program were examined. Depending on the outcome of the procedure, 2 groups of patients were allocated: 1 group - 40 women who had a pregnancy after IVF, 2 group - 80 patients who did not have a pregnancy. The content of IL-1α, TSH, T3, T4 was determined in blood by ELISA. Genotyping was performed on the rs1800587 (C/T) polymorphic marker of the IL-1α gene. TSH, T3, T4 were within the norm for both groups. In our study, women with a TSH concentration of 0.23 to 1.7 nmol/L had a chance of a favorable IVF outcome 1.4 times higher than with other TSH levels (p = 0.042901); with a T3 level of 1.0 to 1.8 nmol/L had a chance of becoming pregnant 5.7 times higher than with other levels of T3 (p = 0.00002). For T4 concentration, the confidence test was not achieved (p = 0.068505). The individual indicators of IL-1α, TSH, T3 and carrier of the genotype of the gene IL-1α at the preconceptive stage have lower diagnostic value than their combined combination. Three combinations have maximum predictive value: a combination of the T/T genotype of the IL-1α gene and the TSH level of 0.23 to 1.7 nmol/l - OR = 8.1 (p = 0.000048); combination of IL-1α of 28.7 to 85.1 pg/ml, T/T gene genotype IL-1α and TSH level of 0.23 to 1.7 nmol/l - OR = 8.1 (p = 0.000048); combination of IL-1α of 28.7 to 85.1 pg/ml, T/T gene genotype IL-1α, TSH level of 0.23 to 1.7 nmol/l and T3 level of 1.0 to 1.8 nmol/l - OR = 8.1 (p = 0.000146). Thus, proposed new prognostic markers of IVF program effectiveness.
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Rottenstreich, A., S. Fridman Lev, R. Rotem, T. Mishael, B. Koslowsky, E. Goldin, S. Grisaru-Granovsky, and A. Bar-Gil Shitrit. "P242 Prior pregnancy outcome is an important determinant of subsequent pregnancy outcome in women with inflammatory bowel diseases." Journal of Crohn's and Colitis 14, Supplement_1 (January 2020): S266—S267. http://dx.doi.org/10.1093/ecco-jcc/jjz203.371.
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Abstract Background Inflammatory bowel diseases (IBD) are commonly diagnosed in women of childbearing age. As such, pregnancy is often encountered in this subset of patients. Disease flare throughout gestation are not uncommon and can substantially affect pregnancy outcomes. We aimed at the effect of prior pregnancy outcome on the risk of disease flare at subsequent pregnancy in women with IBD. Methods Women with IBD attending a multidisciplinary clinic for the preconception, antenatal and postnatal treatment were prospectively recruited during 2011–2018. Results Overall, 476 IBD women were followed during the study period. Of them, 69 (14.5%) had two pregnancies throughout the follow-up period and constituted the study cohort. Among these 69 women, 48 (69.6%) had Crohn’s disease and 21 (30.4%) ulcerative colitis. The median interpregnancy interval was 20 [11–32] months. Overall, 34 (49.3%) women experienced disease flare at the subsequent pregnancy. In multivariate analysis, active disease at conception (odds ratio [95% CI]: 25.65 (3.05, 215.52), p < 0.001) and history of disease flare at the previous pregnancy (odds ratio [95% CI]: 4.21 (1.10, 16.58), p < 0.001) were the only independent predictors of disease relapse in current gestation. Rates of hospitalisation during pregnancy (14.7% vs. 0, p = 0.02) and preterm delivery (32.4% vs. 5.7%, p = 0.006) were higher, and neonatal birth weight was lower (median 3039 vs. 3300 grams, p = 0.03), in those with disease flare as compared with those with maintained remission. Conclusion History of disease relapse at previous gestation and periconception disease activity were found as an important predictor of disease flare among IBD women. These data would facilitate adequate counselling and informed management decisions among reproductive-aged IBD women and their treating physicians.
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Imbasciati, Enrico, and Claudio Ponticelli. "Pregnancy and Renal Disease: Predictors for Fetal and Maternal Outcome." American Journal of Nephrology 11, no. 5 (1991): 353–62. http://dx.doi.org/10.1159/000168338.
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Maso, Martha J., Elizabeth J. Gong, Marc S. Jacobson, Dean S. Bross, and Felix P. Heald. "Anthropometric predictors of low birth weight outcome in teenage pregnancy." Journal of Adolescent Health Care 9, no. 3 (May 1988): 188–93. http://dx.doi.org/10.1016/0197-0070(88)90070-8.
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Cookingham, L. M., E. H. Duran, R. P. Goossen, D. K. Shah, A. Sparks, and B. J. Van Voorhis. "Predictors of Poor Early Pregnancy Outcome after In Vitro Fertilization." Fertility and Sterility 101, no. 2 (February 2014): e25-e26. http://dx.doi.org/10.1016/j.fertnstert.2013.11.100.
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Coricovac, Anca, Dimitrie Nanu, and Laura Dracea. "Predictive factors of outcome in assisted reproductive technologies." Romanian Medical Journal 62, no. 3 (September 30, 2015): 229–36. http://dx.doi.org/10.37897/rmj.2015.3.3.
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Objectives. Study of predictive factors of outcome in assisted reproductive technologies. Material and methods. The retrospective study on a sample that contains information about 1,121 cycles of embryo transfer (ET) from oocytes and sperm autologous procedures. To quantify the relationship between indicators of success and influence factors, a multivariate analysis were used for factors affecting probability of pregnancy (biochemical or clinical) with in vitro fertilization in relation with 14 independent variables (factorial explanatory). Results. Variables with positive influence correlated with biochemical or clinical pregnancy were identified as: type of medication for ovarian stimulation, age of embryo at the day of transfer, number of days of stimulation, number of retrieved oocytes, female age. Conclusion. Study of risk factors and their influence on the success of assisted reproduction technologies may offer new information and could change practice in the field of in vitro fertilization (IVF). Female age, number of days of stimulation and number of retrieved oocytes are predictors for the chance of pregnancy in IVF treatments. More extensive studies are needed, especially studies that focus on the analysis of factors related to embryo quality as predictors of pregnancy in IVF.
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Endeshaw, Gezehagn, and Yifru Berhan. "Perinatal Outcome in Women with Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study." International Scholarly Research Notices 2015 (January 8, 2015): 1–8. http://dx.doi.org/10.1155/2015/208043.
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Background. Hypertensive disorders of pregnancy (HDP) are multisystem diseases known to increase the risk of perinatal mortality worldwide, with a significant proportion of these deaths occurring in low income countries. However, little is known about the obstetric and treatment predictors of perinatal mortality in women with HDP. Methods. A retrospective cohort study design was used to include 1015 hypertensive pregnant women who gave birth to 1110 babies between 2008 and 2013 in three university teaching hospitals. Bivariate and multivariate regression models were used to estimate the associations between selected predictor variables and perinatal mortality taking the onset of HDP illness to death or discharge from the hospital as the time period. Results. There were 322 perinatal deaths resulting in a perinatal mortality rate (PMR) of 290/1000 total births. The proportion of stillbirths was more than 4-fold higher than early neonatal deaths (81% versus 19%). The multivariate analysis demonstrated that multiparity (OR, 1.6; 95% CI, 1.12–228), grand multiparity (OR, 2.8; 95% CI, 1.55–4.92), preterm (OR, 1.5; 95% CI, 1.02–2.35) and very preterm gestational age (OR, 7.7; 95% CI, 5.26–11.20), lack of antenatal care (OR, 2.0; 95% CI, 1.43–2.67), having eclampsia (OR, 4.1; 95% CI, 2.85–6.04), antepartum or before (OR, 6.6; 95% CI, 3.40–12.75) and intrapartum onset of HDP (OR, 4.0; 95% CI, 1.99–8.04), raised SGOT level (OR, 2.3; 95% CI, 1.30–3.91), vaginal delivery (OR, 5.3; 95% CI, 2.93–9.54), low fetal birth weight (OR, 4.3; 95% CI, 2.56–7.23), and maternal death (OR, 12.8; 95% CI, 2.99–54.49) were independent predictors of perinatal mortality. Conclusion. This study showed that the PMR of HDP was among the highest in the world. Parity, gestational age, type and onset of HDP, mode of delivery, birthweight, and maternal outcome were strong predictors of perinatal mortality.
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Winkel, Per, Janus Christian Jakobsen, Jørgen Hilden, Gorm Boje Jensen, Erik Kjøller, Ahmad Sajadieh, Jens Kastrup, et al. "Prognostic value of 12 novel cardiological biomarkers in stable coronary artery disease. A 10-year follow-up of the placebo group of the Copenhagen CLARICOR trial." BMJ Open 10, no. 8 (August 2020): e033720. http://dx.doi.org/10.1136/bmjopen-2019-033720.
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ObjectiveTo assess if 12 novel circulating biomarkers, when added to ‘standard predictors’ available in general practice, could improve the 10-year prediction of cardiovascular events and mortality in patients with stable coronary heart disease.DesignThe patients participated as placebo receiving patients in the randomised clarithromycin for patients with stable coronary artery disease (CLARICOR) trial at a random time in their disease trajectory.SettingFive Copenhagen University cardiology departments and a coordinating centre.Participants1998 participants with stable coronary artery disease.OutcomesDeath and composite of myocardial infarction, unstable angina pectoris, cerebrovascular disease and death.ResultsWhen only ‘standard predictors’ were included, 83.4% of all-cause death predictions and 68.4% of composite outcome predictions were correct. Log(calprotectin) and log(cathepsin-S) were not associated (p≥0.01) with the outcomes, not even as single predictors. Adding the remaining 10 biomarkers (high-sensitive assay cardiac troponin T; neutrophil gelatinase-associated lipocalin; osteoprotegerin; N-terminal pro-B-type natriuretic peptide; tumour necrosis factor receptor 1 and 2; pregnancy-associated plasma protein A; endostatin; YKL40; cathepsin-B), which were all individually significantly associated with the prediction of the two outcomes, increased the figures to 84.7% and 69.7%.ConclusionWhen ‘standard predictors’ routinely available in general practices are used for risk assessment in consecutively sampled patients with stable coronary artery disease, the addition of 10 novel biomarkers to the prediction model improved the correct prediction of all-cause death and the composite outcome by <1.5%.Trial registration numberNCT00121550.
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Gangat, Naseema, Alexandra Wolanskyj, Susan Schwager, and Ayalew Tefferi. "Predictors of Pregnancy Outcome in Essential Thrombocythemia: A Single Institution Study of 63 Pregnancies." Blood 112, no. 11 (November 16, 2008): 1752. http://dx.doi.org/10.1182/blood.v112.11.1752.1752.
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Abstract Background: Essential thrombocythemia (ET) frequently occurs in women of childbearing age. Recently, an increased risk of pregnancy complications was reported in patients with ET carrying the JAK2V617F mutation (Passamonti et al. Blood. 2007;110:485). In the current study, we sought to validate this observation as well as identify other predictors of pregnancy loss in ET. Methods: Data was abstracted from the medical records of a consecutive cohort of patients with WHO-defined ET seen at the Mayo Clinic. Patient characteristics and pregnancy outcome are summarized using descriptive statistics. The analysis of risk factors associated with pregnancy complications was carried out by both univariate and multivariate analyses. Results: i) Patient characteristics at ET diagnosis A total of 63 pregnancies were recorded in 36 women at or after their diagnosis of ET. At diagnosis of ET, median (range) values were: age 26 years (15–36), platelet count 1350 x 109/L (683–3300), hemoglobin level 13.3 g/dL (10.5–16) and leukocyte count 9.3 x109/L (5–26.9). JAK2V617F mutation analysis was performed in 20 patients; half were positive. Only 5 patients had a history of thrombosis at diagnosis. Follow-up after ET diagnosis was for a median of 82.9 months (range, 6.5–340.8 months). ii) Outcome of first pregnancy at or after diagnosis of ET A total of 36 first pregnancies were documented at or after the diagnosis of ET. At the time, median (range) values were: time from diagnosis 25.5 months (0–155), age 28 years (20–36), platelet count 840 x 109/L (255–1998), hemoglobin 12.9 g/dl (9–16.6) and leukocyte count 8.4 x109/L (6.6–19.8). Seven of the 36 (19%) women were receiving cytoreductive therapy at time of conception: anagrelide (n=4), interferon (n=1), hydroxyurea (n=1) and radiophosphorus (n=1). Aspirin therapy was documented in 53% of the women at time of conception and in 69% during the first trimester of their pregnancy. Among the 36 first pregnancies, 61% (n=22) resulted in live birth and 39% (n=14) in fetal loss. Twelve of the 14 pregnancy losses occurred during the first trimester (10 spontaneous miscarriages, 1 ectopic pregnancy and 1 therapeutic abortion) and the remaining two during the second trimester. Maternal complications occurred in 11% (n=4) of pregnancies and included pre-eclampsia (n=1), hematoma after Cesarean-section (n=2) and post-partum hemorrhage (n=1). iii) Predictors of first pregnancy outcome in ET Pregnancy outcome, in terms of live birth versus miscarriage did not correlate with age (p=0.27), presence of cardiovascular risk factor (p=0.76), platelet count (p=0.49), leukocyte count (p=0.67) or hemoglobin level (p=0.31). Similarly, pregnancy loss was similar between JAK2V617F-positive (4 of 10 pregnancies) and JAK2V617F-negative (4 of 10 pregnancies) patients (p>0.9). Furthermore, among 5 cases of 3 consecutive miscarriages, 4 were JAK2V617F-negative. Interestingly, the rate of pregnancy loss was only 21% among 24 patients receiving aspirin therapy during the first trimester as compared to 75% among the 12 patients in whom no such treatment was documented (p=0.002). iv) Second and subsequent pregnancy outcome Seventeen second pregnancies were recorded; 71% (n=12) resulted in live birth that included 8 of 9 patients with successful and 4 of 8 with unsuccessful first pregnancies (p=0.07). The trend was similar among 7 third pregnancies, which resulted in only one live birth; 5 of the 6 fetal losses occurred in women with history of first pregnancy loss (p=0.09). Conclusion: The current study does not support the recently communicated association between the presence of JAK2V617F and increased risk of pregnancy loss in ET. Instead, two parameters of potential importance for predicting pregnancy outcome in ET were identified; the occurrence of a miscarriage might be a marker for a similar event during subsequent pregnancies whereas aspirin therapy during the first trimester might be beneficial.
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Shiao, Shyang-Yun Pamela K., Claire M. Andrews, and Rebecca Jo Helmreich. "Maternal Race/Ethnicity and Predictors of Pregnancy and Infant Outcomes." Biological Research For Nursing 7, no. 1 (July 2005): 55–66. http://dx.doi.org/10.1177/1099800405278265.
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Objective. To examine predictors of pregnancy and infant outcomes, including maternal race/ethnicity. Design. Prospective and observational follow-up of high-risk pregnancies and births. Participants. Three hundred fifty-four mothers and their preterm and/or high-risk live-born neonates were closely followed in three tertiary care centers from the prenatal to postnatal periods for potential high-risk and/or preterm births that required neonatal resuscitations. Major Outcome Measures. Pregnancy complications, birth complications, and infant outcomes were examined in conjunction with maternal factors, including preexisting health problems, health behaviors (smoking, alcohol consumption, prenatal visits), and the birth setting (tertiary care centers or community hospitals). Results. About 22% of these infants were transferred into the tertiary care centers from the community hospitals right after birth; the rest were born in the centers. According to regression analyses, predictors of the birth setting were race (White vs. non-White), maternal health behaviors, pregnancy complications, fetal distress, and the presence of congenital defects for infants (p < .001). Predictors for fetal distress included race (Whites) and pregnancy-induced hypertension (p < .003). Predictors for lower birth weight included race (non-Whites), maternal cigarette smoking, pregnancy complications, fetal distress, and congenital defects (p < .001). Infant mortality rate was 3.9% for these high-risk infants, with the highest rate in infants born to Black mothers (8%). Conclusions. There are obvious health disparities among White and non-White women experiencing high-risk pregnancies and births. Future studies are needed to develop interventions targeted to different racial/ethnic groups during pregnancy to reduce preterm and high-risk births.
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Baharvand, Parastoo, Khatereh Anbari, and Masoud Abdolian. "Health Literacy and Its Predictors Among Pregnant Women: A Cross-sectional Study." Journal of Education and Community Health 9, no. 3 (September 30, 2022): 170–75. http://dx.doi.org/10.34172/jech.2022.25.
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Background: Due to the great importance of health literacy during pregnancy and its direct impact on the health of the mother and her child, this study aimed to evaluate the health literacy of pregnant women in a semi-urban area, Kuhdasht county, located in western Iran and to investigate its associated factors. Methods: This is a cross-sectional study conducted on 300 pregnant mothers referred to a governmental prenatal care center in Kuhdasht county, Iran, in 2019. Data collection tools included a demographic form and the Persian version of the Maternal Health Literacy and Pregnancy Outcome Questionnaire (MHLAPQ). Collected data were then analyzed through SPSS software version 22 using the Pearson correlation test and Multiple linear regression analysis. Results: The mean score for the maternal health literacy dimension was 58.38±8.87 (out of 70), and it was 47.20±6.22 (out of 60) for the pregnancy outcome dimension. This indicates that the current pregnant women had adequate health literacy and pregnancy outcome. Further, there was a significant relationship between maternal health literacy and pregnancy outcome (r=0.58, P=0.001). Moreover, multiple linear regression results indicated that age, occupation, education, ferrous sulfate uptake, history of abortion, frequency of pregnancy, the trimester for prenatal care initiation, and birth weight of infants could not significantly predict health literacy in women (P>0.05). Conclusion: The health literacy level of pregnant women in Kuhdasht county, Iran, is adequate but not high. Accordingly, it is necessary to further consider maternal health literacy in socio-economic and health planning due to its effect on the health of the child and mother.
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Malinowski, A. Kinga, Kevin H. M. Kuo, George A. Tomlinson, Richard Ward, and Nadine Shehata. "Prediction of Risk for Adverse Pregnancy Outcomes in Women with Sickle Cell Disease." Blood 134, Supplement_1 (November 13, 2019): 1009. http://dx.doi.org/10.1182/blood-2019-130087.
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Introduction: Pregnancies in women with Sickle Cell Disease (SCD) are at risk of adverse maternal and fetal outcomes. There are no studies characterizing features predictive of pregnancy-related complications that would enable targeted interventions towards those at high-risk, whilst avoiding exposure of those at low risk to the potential intervention-associated complications. Objective: To explore risk factors associated with adverse pregnancy outcomes in women with SCD and to develop a prediction rule identifying women at different levels of risk for adverse pregnancy outcomes. Methods: Retrospective cohort study of pregnant women with SCD at a tertiary care center. Maternal composite outcome (MCO) includes any of the following: severe, complicated anemia, multi-organ failure, venous thromboembolism, vaso-occlusive episodes requiring admission, blood transfusion, maternal mortality, hypertensive disorder of pregnancy (HDP), cardiac, pulmonary, hepatobiliary, MSK/skin, splenic, neurologic, or renal complication. Fetal composite outcome (FCO) includes any of the following: perinatal mortality, preterm birth, or small for gestational age size. Both composite outcomes were defined a priori. SCD-associated MCO were defined based on a published classification of SCD manifestations. HDP were divided to include gestational hypertension or pre-eclampsia, as noted in the health record. For twin pregnancies, the FCO was considered present if either infant met criteria. Predictor variables included SCD-related and non-SCD related maternal factors, which have been shown in the literature and through clinical experience to potentially result in adverse pregnancy outcomes. For a variable to be interpreted as a potential cause of an adverse outcome, it must have been present before the outcome and must not have been part of the outcome definition. Regression models for MCO and FCO were constructed using generalized estimation equation (GEE) logistic regression with clustering by woman to account for non-independence of outcomes in women with several pregnancies during the study period. From a set of 21 potential predictors for MCO and 26 potential predictors for FCO, those with univariate p-values <0.2 in GEE were included in a multivariable GEE regression model. Using cross-validation, predictive performance of the fitted model was evaluated using the concordance statistic and accuracy of prediction using a calibration curve; for each of 10 90%:10% splits of the dataset, a model was fitted on the 90% and used to obtain predicted probabilities on the 10%. Results: Of 199 pregnancies in 131 women between 1990 and 2016, MCO and FCO occurred in 71% and 45% of pregnancies, respectively. Risk for MCO was predicted by low maternal BMI, low first-trimester hemoglobin, VOE in the year preceding pregnancy, high LDH in pregnancy, history of multiple transfusions, and history of cardiac complications (heart failure, cardiomyopathy, or cardiomegaly). While presence of MCO was not part of the model given the inability to include it in a prediction rule for primiparous women, its manifestation was a risk factor for recurrence in subsequent pregnancies. FCO risk was predicted by older maternal age, high LDH in pregnancy, and maternal composite outcome during pregnancy. The model was discriminative for (a) MCO with a concordance statistic of 0.84 (se=0.03) on the observed data, and a cross-validated value of 0.80 (se=0.03), and (b) FCO with a concordance statistic of 0.72 (se=0.04) on the observed data, and a cross-validated value of 0.69 (se=0.04). Except at the extremes, predicted risk agreed well with observed risk for both the MCO and the FCO (Figure 1). Predicted risk of the MCO, separated pregnancies into groups having as low as a 35% to as high as a 95% chance, while predicted risk of FCO separated pregnancies into groups as low as 10% to as high as 70% (Figure 1). Conclusions: Our study shows that readily available clinical and laboratory variables can predict the degree of risk for an adverse pregnancy outcome in women with SCD. In our models, SCD genotype itself does not predict adverse maternal or fetal outcome, while presence of MCO or FCO are important predictors alongside other prespecified variables. The prediction rules will enable identification of sub-groups of women at higher risk of adverse events, allowing for consideration of targeted interventions such as prophylactic transfusion. Disclosures Malinowski: Alexion: Consultancy, Honoraria. Kuo:Agios: Consultancy; Alexion: Consultancy, Honoraria; Apellis: Consultancy; Bioverativ: Other: Data Safety Monitoring Board; Pfizer: Consultancy; Bluebird Bio: Consultancy; Celgene: Consultancy; Novartis: Consultancy, Honoraria.
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Rausch, Mary E., Richard S. Legro, Huiman X. Barnhart, William D. Schlaff, Bruce R. Carr, Michael P. Diamond, Sandra A. Carson, et al. "Predictors of Pregnancy in Women with Polycystic Ovary Syndrome." Journal of Clinical Endocrinology & Metabolism 94, no. 9 (September 1, 2009): 3458–66. http://dx.doi.org/10.1210/jc.2009-0545.
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Context: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The selection of first-line therapies for ovulation induction is empiric. Objective: The aim of the study was to develop a clinically useful predictive model of live birth with varying ovulation induction methods. Design, Setting, and Participants: We built four prognostic models from a large multicenter randomized controlled infertility trial of 626 women with PCOS performed at academic health centers in the United States to predict success of ovulation, conception, pregnancy, and live birth, evaluating the influence of patients’ baseline characteristics. Interventions: Ovulation was induced with clomiphene, metformin, or the combination of both for up to six cycles or conception. Main Outcome Measure: The primary outcome of the trial was the rate of live births. Results: Baseline free androgen index, baseline proinsulin level, interaction of treatment arm with body mass index, and duration of attempting conception were significant predictors in all four models. History of a prior loss predicted ovulation and conception, but not pregnancy or live birth. A modified Ferriman Gallwey hirsutism score of less than 8 was predictive of conception, pregnancy, and live birth (although it did not predict ovulation success). Age was a divergent predictor based on outcome; age greater than 34 predicted ovulation, whereas age less than 35 was a predictive factor for a successful pregnancy and live birth. Smoking history had no predictive value. Conclusions: A live birth prediction chart developed from basic clinical parameters (body mass index, age, hirsutism score, and duration of attempting conception) may help physicians counsel and select infertility treatments for women with PCOS. The probability of a live birth after ovulation induction in PCOS women can be estimated based on their age, body mass index, hirsutism, and duration of attempted conception.
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Kirk, Emma, and Tom Bourne. "Predicting Outcomes in Pregnancies of Unknown Location." Women's Health 4, no. 5 (September 2008): 491–99. http://dx.doi.org/10.2217/17455057.4.5.491.
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A pregnancy of unknown location (PUL) is a descriptive term used to classify a woman when she has a positive pregnancy test but no intra- or extra-uterine pregnancy is visualized on transvaginal sonography. Expectant management has been shown to be safe for the majority of women with a PUL. Serum progesterone and human chorionic gonadotrophin levels as well as mathematical models play a role in predicting the final outcomes of PULs, which include intrauterine pregnancy, failing PUL and ectopic pregnancy. Other possible predictors of outcome have been studied, but currently no factor has been identified that combines accuracy with reproducibility and simplicity. This article discusses the various aspects of the management of women with PULs. Future work should be aimed at prospectively testing current models in order to predict the outcome of a PUL and minimizing follow-up.
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Liao, C. H., L. C. Wang, S. C. Hsieh, and B. L. Chiang. "AB0424 PREDICTORS OF SLE FLARE-UP AND PREMATURE DELIVERY IN PREGNANCY." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1511.1–1512. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2904.
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Background:Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease that affects many women of child-bearing age, with potentially severe consequences on pregnancy outcome. SLE flare-ups may occur during pregnancy and the post-partum period. Previous studies documenting the incidence and risk factors of flare-up of SLE during pregnancy and puerperium had partially discordant results.Objectives:We aimed to delineate the pregnancy complications of women with SLE, as well as neonatal outcomes of their offspring, and hoped to clarify the incidence and risk factors of SLE flare-ups during pregnancy and puerperium.Methods:We retrospectively reviewed the medical records of SLE patients with previous records of pregnancies in our institution. Flare events during pregnancy and puerperium were documented. The pregnancy outcomes recorded include live births, intra-uterine fetal death (IUFD), premature delivery (< 36 weeks of gestational age), NICU admission, and small for gestational age (SGA, <10thpercentile). Univariate logistic regression was performed to determine the factors associated with disease relapse and pregnancy outcomes.Results:From January, 2000 to December, 2019, a total of 94 SLE patients with 139 pregnancies were identified. The overall live birth rate was 92.4% (134/145). Forty-six (34.3%) of the neonates were delivered prematurely. Forty-six (34.3%) of them were SGA. The admission rate to the neonatal intensive care unit was 25% (30/120). Nine (6.4%) were diagnosed to have SLE during pregnancy. The flare rate during pregnancy was 20% while post-partum 9.4%. The majority of the relapses during pregnancy occurred in the second trimester (46.2%), followed by the first trimester (30.8%), and the third trimester (23.1%). Low complement C3 (C3 < 80mg/dl), thrombocytopenia (PLT < 100*103/uL) at conception, and low serum albumin level at the first trimester were associated with antepartum flare. Presence of disease flare and pre-eclampsia in pregnancy, and low serum albumin level at conception were significantly associated with premature delivery.Conclusion:Low complement C3 and thrombocytopenia at conception, and low serum albumin level at the first trimester were associated with disease flare-up during pregnancy. Patients with relative low serum albumin level at conception, or presence of eclampsia or disease flare-up during pregnancy had a higher risk of premature delivery.References:[1]Shaharir SS, Mohamed Said MS, Mohd R, et al. Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia.PloS one2019;14(9):e0222343.[2]Bundhun PK, Soogund MZ, Huang F. Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: A meta-analysis of studies published between years 2001-2016.Journal of autoimmunity2017;79:17-27.Disclosure of Interests: :None declared
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J., Cicily T., Sherin Sams, and Soniya C. Alphonse. "Pregnancy and heart disease: risk and predictors of obstetric complications." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 6 (May 25, 2017): 2191. http://dx.doi.org/10.18203/2320-1770.ijrcog20172015.
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Background: Although the disease is limited to only 0.5 to 1.0 percent of pregnant women, it remains an important cause of maternal morbidity and even mortality and has a significant effect on fetal outcome. Pregnancy and the peripartum period are associated with important cardiocirculatory changes that can lead to marked clinical deterioration in the woman with heart disease. Objectives of present study were to comprehend the impact of heart disease during pregnancy, to study the maternal and neonatal outcomes of pregnancies in women with heart disease, to identify predictors of pregnancy related complications in women with heart disease and to refine the risk stratification and to assess the individual risk of each pregnant woman with heart disease.Methods: It is a perspective study carried out at College Department of Obstetrics and Gynaecology, Govt. Medical, Kottayam from January 2012 to March 2014.Results: The outcomes of the pregnancies in 100 women who presented with heart disease and received their obstetrical care were evaluated. A maternal cardiac event, neonatal event, or both occurred in 37 completed pregnancies. A cardiac event complicated 8 completed pregnancies. It includes 2 maternal deaths, one on 9th postnatal day in women with hypertrophic obstructive cardiomyopathy and another in women with rheumatoid mitral stenosis who died of congestive cardiac failure. Most cardiac events (75%) occurred in the antepartum period and were either heart failure or cardiac arrhythmia.Conclusions: Strict prenatal care and early risk stratification during gestation are fundamental measures to improve the prognosis of pregnancy in women with heart disease.
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Hingorani, Varshika Mahesh, Dharita S. Shah, Madhura Ghate, and Sachin Patel. "Doppler predictors of perinatal outcome in intra-uterine growth retarded foetuses." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 11 (October 23, 2019): 4298. http://dx.doi.org/10.18203/2320-1770.ijrcog20194846.
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Background: The study aims at early detection of intrauterine growth retarded fetuses which are at high risk of perinatal complications. It can help obstetricians take appropriate preventive steps and prevent serious perinatal complications.Methods: The study undertaken over 100 pregnant women with pregnancy induced hypertension between 28-36 weeks subjected to umbilical artery and uterine artery doppler. The outcome data including gestational age at birth, birth height, APGAR score, admission to NICU, need for positive pressure ventilation and neonatal mortality.Results: The study shows that 58% mothers with IUGR foetuses were primigravida; gestational age at delivery is 34.2 weeks and 82% of IUGR foetuses were delivered by C-section. Average birth weight of foetus with abnormal doppler was significantly lower and there was high incidence of NICU admission. The study also shows that oligohydroamnios was common with abnormal doppler group.Conclusions: Umbilical artery doppler velocity in addition to uterine artery velocity doppler should be considered as a primary tool for foetal surveillance in pregnancy induced hypertension patients and for planning management of IUGR foetuses.
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Lapshtaeva, A. V., I. V. Sychev, A. I. Adamchik, I. V. Evsegneeva, and V. V. Novikov. "Предикторы неблагоприятного исхода программ экстракорпорального оплодотворения." Voprosy ginekologii, akušerstva i perinatologii 20, no. 1 (2021): 22–28. http://dx.doi.org/10.20953/1726-1678-2021-1-22-28.
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Identification of factors determining both adverse and favorable outcome of IVF will increase the effectiveness of this method and optimize infertility treatment. Objective. The aim of the research is to determine the relationship between hormonal and cytokine status indicators with an adverse outcome of the IVF procedure in women with tubal-peritoneal infertility. Patients and methods. The study involved 120 women with tubal-peritoneal infertility who underwent a “short” protocol of stimulation of superovulation in the IVF program. Depending on the result, women were divided into two groups: group 1 – with clinically confirmed pregnancy (n = 40), group 2 – non-pregnant women (n = 80). The content of IL-1α, IL-1β, IL-1Ra and hormones in serum were determined by ELISA. Genotyping of polymorphic markers rs1800587 (C/T) of the IL-1α gene, rs16944 (С511Т) of the IL-1β gene and rs2234663 (2/4) of the IL-1Ra gene was performed. Results. Markers of adverse IVF outcome that had prognostic significance were: C/C genotype of the IL-1α gene (OR = 2 [0.9–4.6], p = 0.043113), serum IL-1α concentration <11.4 pg/mL (OR = 3, 2 [1.1-9.1], p = 0.025347), endometrial thickness on the 2nd day of the menstrual cycle was >5 mm (OR = 3.2 [1.1–9.1], p = 0.025347), the concentration of prolactin on the 3rd day of the menstrual cycle was >363.8 mU/mL (OR = 6.3 [1.8–22.2], p = 0.001745), genotype T/T of the IL-1β gene (OR = 15.8 [5.1–48.9], p < 0.001), the concentration of progesterone was <16 nmol/L (OR = 22.2 [2.3–170], p = 0.000057). Key words: cytokines, IVF, IL-1α, IL-1β, IL-1Rа, rs1800587, rs16944, rs2234663
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Bolduc, Stéphane, Marc Anthony Fischer, Genevieve Deceuninck, and Michel Thabet. "Factors predicting overall success: a review of 747 microsurgical vasovasostomies." Canadian Urological Association Journal 1, no. 4 (March 4, 2013): 388. http://dx.doi.org/10.5489/cuaj.454.
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Objectives: Advances in surgical techniques have improved the outcome of microsurgical vasovasostomy (VV). We performed a retrospective analysis of surgical procedures to determine outcomes and predictors of VV success, to develop Kaplan–Meier Curves for predicting VV outcomes and to evaluate the use of α-glucosidase (AG) to predict outcomes.Patients and Methods: We undertook a retrospective analysis of 747 modified 1-layer microsurgical VV procedures performed between 1984 and 2000. Obstructive interval, partner status, social status preoperatively and method of vasal obstruction, vasal fluid quality and sperm granuloma intraoperatively were compared with outcome results. Parameters evaluated at follow-up included semen analysis, AG concentration in ejaculate fluid and pregnancy rates.Results: The overall patency rate was 86% and pregnancy rates were 33% and 53% at 1 and 2 years after primary VV, respectively. Preoperative factors associated with successful outcome and pregnancy included shorter obstructive interval and same female partner (p < 0.05). Intraoperative factors predicting success included the use of surgical clips instead of suture at vasectomy, the presence of a sperm granuloma, the presence and quality of vasal fluid, and the presence and quality of sperm in vasal fluid. Further, increased AG in the postoperative semen predicted improved patency and pregnancy outcomes.Conclusion: This study confirms the effectiveness of VV for vasectomized men who wish to father children. It also demonstrates that preoperative and intraoperative factors are predictive of the VV outcome. Postoperative AG is also a useful marker of patency and it appears to predict pregnancy outcome.
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Walter, Isabel Johanna, Mirthe Jasmijn Klein Haneveld, Anne Titia Lely, Katharina Wilhelmina Maria Bloemenkamp, Maarten Limper, and Judith Kooiman. "Pregnancy outcome predictors in antiphospholipid syndrome: A systematic review and meta-analysis." Autoimmunity Reviews 20, no. 10 (October 2021): 102901. http://dx.doi.org/10.1016/j.autrev.2021.102901.
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LINARES, L. ORIANA, BONNIE J. LEADBEATER, LESLIE JAFFE, PAMELA M. KATO, and ANGELA DIAZ. "Predictors of Repeat Pregnancy Outcome among Black and Puerto Rican Adolescent Mothers." Journal of Developmental & Behavioral Pediatrics 13, no. 2 (April 1992): 89–94. http://dx.doi.org/10.1097/00004703-199204000-00002.
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Birukov, Anna, Louise Bjørkholt Andersen, Florian Herse, Natalia Rakova, Gitte Kitlen, Henriette Boye Kyhl, Michaela Golic, et al. "Aldosterone, Salt, and Potassium Intakes as Predictors of Pregnancy Outcome, Including Preeclampsia." Hypertension 74, no. 2 (August 2019): 391–98. http://dx.doi.org/10.1161/hypertensionaha.119.12924.
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Owen, P. "Routine ultrasound scanning in pregnancy. Apgar scores are poor predictors of outcome." BMJ 307, no. 6903 (August 28, 1993): 559–60. http://dx.doi.org/10.1136/bmj.307.6903.559-c.
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Zhang, Z., L. L. Zhu, H. S. Jiang, H. Chen, Y. Chen, and Y. T. Dai. "Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes." Andrologia 48, no. 9 (January 19, 2016): 962–69. http://dx.doi.org/10.1111/and.12525.
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Erjavec, Katja, Tamara Poljičanin, and Ratko Matijević. "Impact of the Implementation of New WHO Diagnostic Criteria for Gestational Diabetes Mellitus on Prevalence and Perinatal Outcomes: A Population-Based Study." Journal of Pregnancy 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/2670912.
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Objectives. To determine the impact of the implementation of new WHO diagnostic criteria for gestational diabetes mellitus (GDM) on prevalence, predictors, and perinatal outcomes in Croatian population.Methods. A cross-sectional study was performed using data from medical birth certificates collected in 2010 and 2014. Data collected include age, height, and weight before and at the end of pregnancy, while perinatal outcome was assessed by onset of labor, mode of delivery, and Apgar score.Results. A total of 81.748 deliveries and 83.198 newborns were analysed. Prevalence of GDM increased from 2.2% in 2010 to 4.7% in 2014. GDM was a significant predictor of low Apgar score (OR 1.656), labor induction (OR 2.068), and caesarean section (OR 1.567) in 2010, while in 2014 GD was predictive for labor induction (OR 1.715) and caesarean section (OR 1.458) only. Age was predictive for labor induction only in 2014 and for caesarean section in both years, while BMI before pregnancy was predictive for all observed perinatal outcomes in both years.Conclusions. Despite implementation of new guidelines, GDM remains burdened with increased risk of labor induction and caesarean section, but no longer with low Apgar score, while BMI remains an important predictor for all three perinatal outcomes.
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Lackovic, Milan, Dejan Filimonovic, Sladjana Mihajlovic, Biljana Milicic, Ivana Filipovic, Marija Rovcanin, Dejan Dimitrijevic, and Dejan Nikolic. "The Influence of Increased Prepregnancy Body Mass Index and Excessive Gestational Weight Gain on Pregnancy Course and Fetal and Maternal Perinatal Outcomes." Healthcare 8, no. 4 (September 24, 2020): 362. http://dx.doi.org/10.3390/healthcare8040362.
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Background: The aim of our study was to assess the influence of prepregnancy Body Mass Index (BMI) changes as well as excessive gestational weight gain (GWG) on maternal and fetal perinatal parameters. Furthermore, we aimed to analyze the influence of increased prepregnancy BMI values and excessive GWG on neonatal early motoric development. Methods: The 203 eligible female participants were evaluated. Prepregnancy Body Mass Index (BMI) and excessive gestational weight gain (GWG) defined according to Institute of Medicine 2009 guidelines in the USA were assessed with tested maternal and fetal perinatal parameters and infants early motoric development (Alberta Infant Motor Scale—AIMS). Results: Significant predictors of increased prepregnancy BMI in perinatal period include: weight at delivery (p = 0.001), GWG (p = 0.002) and BMI at delivery (p < 0.001), while significant predictors of excessive GWG in perinatal period are: prepregnancy BMI (p = 0.029) and BMI at delivery (p < 0.001). In the group of participants with both increased prepregnancy BMI and excessive GWG versus others, significant predictors were: hypertension (HTA) (p = 0.019), amniotic fluid index (AFI) (p = 0.047), Pronation (AIMS) (p = 0.028) and Supination (AIMS) (p = 0.029). Conclusion: Increased prepregnancy BMI and excessive GWG are significantly associated with numerous perinatal factors that could alter the pregnancy course, pregnancy outcome and early motoric development of newborn. Moreover, increased prepregnancy BMI is shown to be a significant predictor of excessive GWG; thus, early selection of pregnant women for close monitoring of weight gain during pregnancy will have positive effects on reducing the risk of less favorable pregnancy course and early motoric development of newborn.
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Fakhraei, Romina, Kathryn Denize, Alexandre Simon, Ayni Sharif, Julia Zhu-Pawlowsky, Alysha L. J. Dingwall-Harvey, Brian Hutton, et al. "Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review." International Journal of Environmental Research and Public Health 19, no. 4 (February 12, 2022): 2063. http://dx.doi.org/10.3390/ijerph19042063.
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Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome (n = 32), followed by preterm birth (n = 29), preeclampsia (n = 27), low birthweight infants (n = 20), small for gestational age newborns (n = 12), and stillbirth (n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age < 20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.
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Srinivasa, S., and Muragesh Awati. "Perinatal outcomes of hypertensive disorders of pregnancy." Karnataka Pediatric Journal 35 (January 25, 2021): 105–9. http://dx.doi.org/10.25259/kpj_21_2020.
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Objectives: Hypertensive disorders of pregnancy (HDP) are multisystem diseases, which include chronic (preexisting) hypertension, gestational hypertension, pre-eclampsia, eclampsia, and pre-eclampsia superimposed on chronic hypertension. These disorders may complicate 5%–10% of all pregnancies and are leading causes of maternal and perinatal mortality and morbidity worldwide. This study was done to assess the incidence of HDP and perinatal outcomes in comparison to normal pregnancy. The objectives of this study were to assess the incidence of HDP and its correlation with perinatal outcome. Materials and Methods: Eighty patients were enrolled for the study, Group A (cases) – 40 patients of HDP and Group B (controls) – 40 normotensive controls, these 40 normotensive controls were properly matched with Group A with respect to age and gestational age. The collected data were analyzed with IBM SPSS statistics software 23.0 Version XVII. Results: In Group A, 45% were gestational hypertensive patients, 35% were pre-eclamptic patients, 12.5% eclampsia, and 7.5% chronic hypertension. Perinatal morbidity and mortality were increased in HDP when compared with age and gestational age-matched controls. Perinatal mortality was seen in 10% in Group A. In Group B(controls) there were no perinatal mortalities. Conclusion: The study demonstrated that high parity, low gestational age, lack of antenatal care, having eclampsia, pre-delivery onset of HDP, vaginal delivery, low fetal birth weight, and maternal death were independent predictors of perinatal mortality. The majority of perinatal mortality predictors were also predictors of stillbirths. The strong association of perinatal mortality with eclampsia (a late complication of HDP in the majority) and lack of antenatal care is an indirect evidence for the delay in the utilization of obstetric services.
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Neves, Paulo A. R., Chiara A. S. Campos, Maíra B. Malta, Bárbara H. Lourenço, Márcia C. Castro, and Marly A. Cardoso. "Predictors of vitamin A status among pregnant women in Western Brazilian Amazon." British Journal of Nutrition 121, no. 2 (November 15, 2018): 202–11. http://dx.doi.org/10.1017/s0007114518003112.
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AbstractDetermining the predictors of serum retinol at mid-pregnancy is relevant for planning interventions aimed at improving vitamin A status of pregnant women and their offspring. This prospective study assessed predictors of serum retinol at the beginning of the third trimester of pregnancy. We enrolled 442 pregnant women living in the urban area of Cruzeiro do Sul, Western Brazilian Amazon. Demographic, socio-economic, environmental and clinical characteristics as well as obstetric history, anthropometric, dietary and biochemical data, including serum retinol, were gathered between 16 and 20 gestational weeks. Serum retinol also measured at the beginning of the third trimester of pregnancy (approximately 28 gestational weeks) was the outcome of interest. Multiple linear regression models were used to evaluate associations with the outcome. Overall, the following variables explained serum retinol at the beginning of the third trimester of pregnancy in the adjusted model (R2 = 11·1 %): seasonality (winter season – November to April; β=0·134; 95 % CI 0·063, 0·206), weekly consumption of Amazonian fruits (β=0·087; 95 % CI 0·012, 0·162) and retinol concentrations between 16 and 20 gestational weeks (β=0·045; 95 % CI 0·016, 0·074) were positively associated, whereas having a smoker in the house was negatively associated (β=–0·087; 95 % CI: –0·166, –0·009). Consumption of pro-vitamin A-rich fruits by pregnant women should be encouraged. Passive smoking may play a role in decreasing vitamin A status as a proxy of smoking exposure during pregnancy.
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HUNT, Sarah, Xiaohong LI, Shan LUO, Wei HUANG, and Ben MOL. "Inter-Cycle Variation in Endometrial Thickness in Fresh Embryo Transfer Cycles: Predictors and Association with Pregnancy Outcome." Fertility & Reproduction 04, no. 03n04 (September 2022): 151. http://dx.doi.org/10.1142/s2661318222740632.
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Background: The use of intracytoplasmic sperm injection (ICSI) has increased substantially worldwide, primarily in couples with non-male factor infertility. We recently published the results of a large randomised controlled trial (RCT) comparing ICSI and IVF showing no significant improvement of ICSI over IVF in couples with normal semen concentration and motility. Here, we assess the cost-effectiveness of ICSI in these couples, with additional attention for subgroups. Aim: To evaluate the inter-cycle variation in endometrial combined thickness (ECT) in fresh embryo transfer cycles Method: This was a retrospective cohort study in a single university affiliated fertility clinic in Chengu, China. We studied women undergoing IVF/ ICSI treatment in a fresh stimulated cycle, and measured endometrial combined thickness on the day of HCG trigger in consecutive stimulated IVF/ICSI cycles. Inter-cycle variation in ECT was the main outcome measure. Secondary outcomes were the relationship between ECT and treatment outcomes clinical pregnancy, live birth and miscarriage. Results: The mean ECT in consecutive fresh stimulated cycles was 10.28 ⊠ 2.15mm in cycle 1 (n=7038), 9.93 ⊠ 2.11mm in cycle 2 (n=1287), 9.49 ⊠ 2.22mm in cycle 3 (n=148) and 8.63 ⊠ 1.82mm in cycle 4 (n=17) (p [Formula: see text]0.01.). An incremental increase in the clinical pregnancy rate was demonstrated for each additional millimetre in ECT up to a threshold level of 12-15mm. There was no evidence of systematic bias on the visual assessment of the Bland Altman plot in women undergoing 2 consecutive cycles of treatment (mean bias 0.46, (95% limits of agreement -5.62 to 5.65)). Multivariate predictors of ECT were the number of previous treatment cycles, secondary infertility, infertility diagnoses of anovulation, endometriosis, male factor or unexplained infertility and the number of follicles greater than 14mm on the day of HCG trigger. There was a small, significant interaction between female age and ECT on the outcome clinical pregnancy. Conclusion: There is a slight decrease in mean ECT in women undergoing consecutive stimulated IVF/ICSI cycles which is potentially explained by the increased occurrence of pregnancy with thicker ECT. Each millimetre increase in late follicular ECT increases the odds ratio of clinical pregnancy to a threshold level of 12-15mm.
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Jeremic, Katarina, Aleksandar Stefanovic, Jelena Dotlic, Sasa Kadija, Olivera Kontic, Miroslava Gojnic, Jelena Jeremic, and Vesna Kesic. "Cancer during pregnancy – clinical characteristics, treatment outcomes and prognosis for mothers and infants." Journal of Perinatal Medicine 46, no. 1 (January 26, 2018): 35–45. http://dx.doi.org/10.1515/jpm-2016-0212.
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AbstractObjective:To assess which obstetrical characteristics and treatment improved outcomes and prognosis of pregnant women with malignancy.Methods:A prospective study, undertaken between 2005 and 2014, involving 35 pregnant women who were diagnosed with malignant tumors during pregnancy. Patients were followed-up for 1 year after delivery. The pregnancy course and outcome and parameters that could influence the condition of mother and fetus were evaluated.Results:Most malignancies were hematological, diagnosed in the second trimester and treated with combined therapy (surgery/adjuvant) after pregnancy. Most fetuses were in good state throughout pregnancy, but were delivered by caesarean section (CS) before term. Adjuvant therapy during pregnancy mostly caused transitory deterioration of fetal conditions. The majority of both mothers and infants were in a good state 12 months postpartum, although numerous mothers were still ill and on therapy. Surviving pregnancy and preventing tumors progression during pregnancy were the best predictors of mothers’ future condition (P=0.022). High birthweight and term delivery were the most important factors for good outcome of the infants (P=0.001).Conclusions:If the tumor is not progressing, pregnancy should be continued as long as possible to obtain adequate birthweight of the infant. Second trimester surgery is safe, while other therapies should preferably be applied after delivery.
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Levin, Gabriel, and Amihai Rottenstreich. "Earlier predictors for treatment outcome among single dose methotrexate for an ectopic pregnancy." Archives of Gynecology and Obstetrics 300, no. 3 (July 18, 2019): 793. http://dx.doi.org/10.1007/s00404-019-05250-5.
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Journal, Baghdad Science. "Impact of maternal risk factors on the outcome of pregnancy in Baghdad city." Baghdad Science Journal 7, no. 1 (March 7, 2010): 813–20. http://dx.doi.org/10.21123/bsj.7.1.813-820.
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To find out the impact of maternal risk factors on the outcome of pregnancy in Baghdad city. A descriptive purposive study was carried out on 100 postpartum women who had delivered for 1 hr. to 24 hrs. ago . the study sample was selected from three hospitals in Baghdad city ( Baghdad teaching hospital ,Fatima Al-Zahra'a maternity and pediatric teaching hospital and Al-Yarmook teaching hospital),during the period from 25 Jan. to 25 Feb. 2006. The data were collected through the use of questionnaire format reviewing pregnants' records and personal interview and were analyzed by using descriptive and inferential statistical approaches. The finding revealed that maternal pregnancy complications had weak effects on pregnancy outcome , while maternal employment & spouse's consanguinity were predictors for poor pregnancy outcome . The study recommended the necessity of establishing health education programs for pregnant to be self monitoring & early detection of complications that associate the pregnancy . In addition promote the system of follow up care during antenatal ,perinatal,& postnatal.
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Bello, Folasade Adenike, Oladapo Olayemi, Christopher O. Aimakhu, and Adeyemi O. Adekunle. "Effect of Pregnancy and Childbirth on Sexuality of Women in Ibadan, Nigeria." ISRN Obstetrics and Gynecology 2011 (October 5, 2011): 1–6. http://dx.doi.org/10.5402/2011/856586.
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A study of 375 antenatal attendees to assess women's views and experience in sexual matters during pregnancy and following childbirth. Explanatory variables included the perception women had of sex during pregnancy and after childbirth. Outcome variables were frequency and satisfaction of sexual activity. The commonest reasons for having coitus in pregnancy were marital harmony and facilitation of delivery. Libido rose throughout pregnancy but orgasms were less often experienced. The man-on-top position became less practised. Vaginal intercourse remained the commonest type. Masturbation and anal intercourse increased, while oral sex declined throughout. Marriage (OR 9.0, 95% CI 1.0–79.5) and current cohabitation (OR 13.6, 95% CI 1.6–113.4) were predictors of sex in pregnancy. Dyspareunia and partners' extramarital affairs were deterrent. Vaginal delivery and episiotomy were not significant predictors of postnatal sex. The respondents and their partners seem able to adapt to pregnancy changes and enhance their marital bonds. Anticipatory guidance and informed counselling may encourage this.
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Alder, Judith, Gertrud Breitinger, Cristina Granado, Isabel Fornaro, Johannes Bitzer, Irene Hösli, and Corinne Urech. "Antenatal Psychobiological Predictors of Psychological Response to Childbirth." Journal of the American Psychiatric Nurses Association 17, no. 6 (November 2011): 417–25. http://dx.doi.org/10.1177/1078390311426454.
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Background: Several psychological and obstetric predictors of a negative childbirth experience and traumatic response to delivery have been identified. However, the influence of antepartum physiological stress parameters has not been elucidated. Objective: The study includes an exploratory analysis of the associations of fear of delivery, antenatal basal and reactive activity of the hypothalamic–pituitary–adrenal axis, and obstetric outcomes, with childbirth experience and posttraumatic avoidance in the postpartum period. Design: This was a prospective study with two antenatal measurements and a final assessment during the first week postpartum. An experimental condition with a standardized stressor (Trier Social Stress Test) was included in the design to study psychobiological stress response as a predictor of traumatic birth and posttraumatic avoidance. Results: Linear regression analyses show independent associations of fear of delivery and more pronounced antenatal cortisol awakening response with a more negative childbirth experience. Fear of delivery was mediated by state anxiety after stress exposure, which, together with cortisol awakening response, explained 16% of the variance in the outcome of a more negative childbirth experience. Finally, antenatal fear of delivery and a negative childbirth experience both predicted higher avoidance scores during the first week postpartum. Conclusions: The associations found in this study can improve identification during pregnancy of women at risk for negative psychological response to childbirth. For these women, the provision of supportive care during pregnancy should be evaluated.
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Cohn, Danny M., Saskia Middeldorp, Johanna C. Korevaar, Feroza Dawood, Harry R. Büller, Mariëtte Goddijn, and Roy Farquharson. "Recurrent Miscarriage in Women with and without Antiphospholipid Syndrome: Prognosis and Predictors of a Subsequent Successful Delivery." Blood 114, no. 22 (November 20, 2009): 2971. http://dx.doi.org/10.1182/blood.v114.22.2971.2971.
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Abstract Abstract 2971 Poster Board II-947 Introduction: Women with antiphospholipid syndrome (APS) are at increased risk of recurrent miscarriage. Remarkably, the outcome of a successive pregnancy in women with APS and recurrent miscarriage is merely unknown. Patients and methods: We performed a cohort study including all women with 2 or more consecutive miscarriages who attended the recurrent miscarriage clinic of Liverpool Women's Hospital, Liverpool, UK between 1988 and 2006. All women underwent a systematic diagnostic work up including testing for APS. Women with proven APS (according to the SAPPORO criteria) were studied, and outcomes were compared to women with unexplained recurrent miscarriage. We excluded all women from couples with other reasons for recurrent miscarriage. Results: 737 women were included, of whom 220 (30%) had APS. Mean age (32 years) and obstetric history (mean number of prior losses: 3) did not differ between women with and without APS. Of women with APS, 148 (67%) had a successful pregnancy outcome as compared to 324 women without APS (63%), OR=1.2 (95%CI 0.9 to 1.7). No differences were found for birth weight, gestational age, and intra-uterine growth retardation. Women with APS who received aspirin and heparin more often had a successful pregnancy 53/67 (79%) as compared to women without treatment 26/44 (59%); OR=2.6 (95%CI 1.0 to 6.6). Combined use of aspirin and heparin was not associated with an increased success rate in women without APS: 25/43 (58%) vs 204/305 (67%); OR=0.7 (95%CI 0.3-1.4). Conclusions: The prognosis of a successive pregnancy in women with recurrent miscarriage and APS was comparable to women with unexplained recurrent miscarriage. However, the combined use of heparin and aspirin was associated with a significantly increased chance of a successful pregnancy in women with APS. Disclosures: No relevant conflicts of interest to declare.
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Laube, Robyn, Yunki Yau, Christian P. Selinger, Cynthia H. Seow, Amanda Thomas, Sai Wei Chuah, Ida Hilmi, et al. "Knowledge and Attitudes Towards Pregnancy in Females with Inflammatory Bowel Disease: An International, Multi-centre Study." Journal of Crohn's and Colitis 14, no. 9 (March 11, 2020): 1248–55. http://dx.doi.org/10.1093/ecco-jcc/jjaa047.
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Abstract Background and Aims Poor knowledge of inflammatory bowel disease [IBD] in pregnancy underlies unwarranted voluntary childlessness [VC], and risks poorer obstetric outcomes and adverse fetal outcomes. IBD is increasing worldwide but education on IBD issues might be heterogeneous based on cultural differences and variations in models of care. Methods Consecutive female IBD subjects aged 18–45 years were prospectively recruited from two dedicated IBD-pregnancy clinics, two multidisciplinary IBD clinics and nine general gastroenterology clinics. Subjects completed the validated CCPKnow [score 0–17] with questions on demographics, medical history and pregnancy knowledge. The primary outcome was knowledge per clinic-type and per geographical region. Results Surveys were completed by 717 subjects from 13 hospitals across ten countries. Dedicated IBD-pregnancy clinics had the highest knowledge, followed by multidisciplinary IBD clinics then general IBD clinics (median CCPKnow 10.0 [IQR: 8.0–11.0], 8.0 [IQR: 5.0–10.5] and 4.0 [IQR:2.0–6.0]; p < 0.001). Median CCPKnow scores in Western, Asian and Middle Eastern clinics were 9.0, 5.0 and 3.0 respectively [p < 0.001]. Dedicated IBD-pregnancy clinics, IBD support organization membership, childbearing after IBD diagnosis and employment independently predicted greater knowledge. Patient perception of disease severity [r = −0.18, p < 0.01] and consideration of VC [r = −0.89, p = 0.031] negatively correlated with CCPKnow score. The overall VC rate was 15.0% [95% CI: 12.2–18.2]. VC subjects had significantly lower pregnancy-specific IBD knowledge than non-VC subjects (median CCPKnow 4.0 [IQR: 2.0–6.0] and 6.0 [IQR: 3.0–9.0] respectively; p < 0.001). Pregnancy-specific IBD knowledge and dedicated IBD-pregnancy clinic attendance were significant negative predictors of VC. Conclusions In this large international study we identified predictors of pregnancy-specific IBD knowledge. Dedicated IBD-pregnancy clinics had the greatest IBD-related pregnancy knowledge and lowest VC rates, reflecting the benefits of pre-conception counselling.
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Al-Mousawi, Bushra J., Maanee A. H. Al-Azzam, Balsam Al-Zahawi, and Hayder A. Fawzi. "Agonist Versus Antagonist in Intracytoplasmic Sperm Injection Cycles: Which Is the Best?" International Journal of Women's Health and Reproduction Sciences 8, no. 3 (October 1, 2019): 285–89. http://dx.doi.org/10.15296/ijwhr.2020.46.
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Objectives: The comparison of gonadotropin-releasing hormone (GnRH) agonist against GnRH antagonists regarding the pregnancy rate and effect of various predictors on pregnancy outcomes. Materials and Methods: This prospective comparative study involved 189 women who underwent intracytoplasmic sperm injection (ICSI) cycles and were divided into agonist (107 patients) and antagonist arm (82 patients) groups. The chemical and clinical pregnancy rate was the main outcome and the other outcomes included the number and quality of oocyte measurement and pregnancy outcomes. Results: Based on the results, the agonist protocol showed a higher rate of pregnancy (32.7%, 95% CI: 23.9-42.4%) compared to the antagonist protocol (22.0%, 95% confidence interval (CI): 13.6-32.5%) with the odds ratio (OR) of (95% CI) = 1.73 (0.89-3.35). The results further revealed that the count of retrieved oocytes, count of M2 oocytes, count of fertilized oocytes, count of embryos, and the fertilization percent out of total retrieved oocytes were higher in the agonist arm compared to the antagonist arm. In the multivariate analysis after adjusting for the confounders, the agonist protocol had higher odds of a successful pregnancy compared to the antagonist protocol by 57% (partial OR = 1.57, P value = 0.23). Conclusions: In general, the agonist protocol offers a favourable outcome in comparison to the antagonist arm, and there seems to be an intrinsic benefit for the agonist protocol, which is not explained by the higher number of transferred embryos.
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Bamniya, Jaishree, Divyesh Panchal, Pooja Singh, Ami Shah, and Harshad Ladola. "Early sonographic markers and prediction of pregnancy outcome: a prospective study." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 6 (May 25, 2017): 2471. http://dx.doi.org/10.18203/2320-1770.ijrcog20172333.
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Background: The objective of the study was to examines the pregnancy outcome in patients with early sonography markers and study design was a prospective study.Methods: This prospective study was conducted at Department of Obstetrics and Gynaecology, GCS Medical College, Ahmedabad, Gujarat, India from Feb 2012 to August 2016. Total of 612 Women with early pregnancy were included in the study that fulfilled the inclusion criterias. After first sonography examination patients were assigned to the control group and study group. Patients were followed up for outcome.14 pateients were lost to follow up.Results: The incidence of pregnancy loss was highest with Large yolk sac i.e 78.57%, followed by loss with Bradycardia (38%), Tachycardia (15.78%) and Smaller than normal G Sac to be 14.28%. As compared to control which had pregnancy loss of only 7.7%. Incidence of other complications like IUGR, PIH were also increased in patients with abnormal early sonography markers up to 33%.Conclusions: T Transvaginal sonography should be used adequately to look for early pregnancy markers like Size of Gestational sac, size and shape of yolk sac, fetal heart rate and in cases of threatened abortion presence of subchorionic haematoma and its size because all these markers are good predictors of pragnacy outcome and can prove helpful in patient counseling.
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Attanasio, Monica, Michela Cirillo, Maria Elisabetta Coccia, Giancarlo Castaman, and Cinzia Fatini. "Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?" Mediterranean Journal of Hematology and Infectious Diseases 12, no. 1 (August 29, 2020): e2020058. http://dx.doi.org/10.4084/mjhid.2020.058.
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A growing number of infertile women are considering pregnancy through assisted reproductive technologies; hormonal fertility treatment is associated with a procoagulant milieu. In oocyte donation Assisted Reproductive Technologies there are patients who experience repeated implantation failures, as well as biochemical pregnancy, in particular in women at advanced age (>40 yrs). No information is available concerning coagulation changes in women undergoing oocyte donation.
In this study, we decided to identify changes in haemostasis in women undergoing infertility treatment and their relationship with clinical pregnancy outcome.
Our findings evidence an early increase of FVIII and VWF coagulation proteins, suggesting their potential role as early “predictors” of a successful clinical pregnancy in oocyte donation women. This may be intriguing for exploring potential mechanisms responsible for the establishment of a successful pregnancy after oocyte donation.
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Anwar, Aqsa, Faiza Sharif, and Zuhaib Saleem. "Predictors of Disability Attributed to Symptoms of Increased Interrecti Distance in Pregnant and Postpartum Women with Diastasis Rectus Abdominis." Healer Journal of Physiotherapy and Rehabilitation Sciences 2, no. 1 (June 30, 2022): 88–96. http://dx.doi.org/10.55735/thjprs.v2i1.46.
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Background: Physically and physiologically, pregnancy and parturition are the phases of transformation for women. During pregnancy, the rectus abdominis muscles move laterally, and the interrecti distance increases and may remain increased in the immediate post-birth period which can lead to disability. Objective: To investigate various physical and physiological factors that can cause disability attributed to symptoms of increased interrecti distance after childbirth. Methods: This cross-sectional survey was conducted from after approval from the ethical committee. About 239 postpartum females with age ranges of 25 to 35 years having an interrecti distance of at least 2 cm and whose youngest child ages between 1 to 8 years were included. Correlation analysis was applied for different variables using Pearson correlation with a disability as the outcome variable and fear-avoidance beliefs, emotional distress, body mass index, lumbopelvic pain, increased interrecti distance, and physical activity level as predictor variables. Results: Four strong predictors were considered that cause disability in the postpartum females with almost 2 finger-width increased interrecti distance at baseline. All patients reported disability caused by symptoms produced by these strong independent predictors like body mass index, fear-avoidance, depression/anxiety, and lumbopelvic pain. The disability was caused by symptoms of body mass index of 22%, with Tampa scale of kinesiophobia questionnaire fear-avoidance belief cause disability 23.4%, with hospital anxiety and depression score was 10%, and with lumbopelvic pain 16% or mean value of visual analog scale 5.78% and total score of pain disability index was reported 9%. The p-value for correlation of all predictor variables with disability outcome variable shows a significant correlation between them. Conclusion: The intensity of lumbopelvic pain, fear-avoidance attitudes, body mass index, and emotional distress are the primary causes of disability related to symptoms of an increased interrecti distance after childbirth. These four predictor variables show a significant correlation with disability.
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Yue, Chao-Yan, Chun-Yi Zhang, Ying-Hua Ni, and Chun-Mei Ying. "Are serum levels of inhibin A in second trimester predictors of adverse pregnancy outcome?" PLOS ONE 15, no. 5 (May 29, 2020): e0232634. http://dx.doi.org/10.1371/journal.pone.0232634.
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