Log in

Relevant bibliographies by topics / Prebiotic molecules

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers

Academic literature on the topic 'Prebiotic molecules'

Author: Grafiati

Published: 14 September 2022

Last updated: 10 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Prebiotic molecules.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Prebiotic molecules"

1

Rinninella, Emanuele, and Lara Costantini. "Polyunsaturated Fatty Acids as Prebiotics: Innovation or Confirmation?" Foods 11, no. 2 (January 6, 2022): 146. http://dx.doi.org/10.3390/foods11020146.

Full text

Abstract:

The International Scientific Association for Probiotics and Prebiotics (ISAPP), in its last consensus statement about prebiotics, defined polyunsaturated fatty acids (PUFAs) as “candidate prebiotics” due to a lack of complete scientific evidence. Previous studies have demonstrated the ability of microbiota to metabolize PUFAs, although the role of the resulting metabolites in the host is less known. Recent partial evidence shows that these metabolites can have important health effects in the host, reinforcing the concept of the prebiotic action of PUFAs, despite the data being mostly related to omega-6 linoleic acid and to lactobacilli taxon. However, considering that the symbionts in our gut benefit from the nutritional molecules that we include in our diet, and that bacteria, like all living organisms, cannot benefit from a single nutritional molecule, the concept of the “correct prebiotic diet” should be the new frontier in the field of gut microbiota research.

APA, Harvard, Vancouver, ISO, and other styles

2

Thaddeus, P. "The prebiotic molecules observed in the interstellar gas." Philosophical Transactions of the Royal Society B: Biological Sciences 361, no. 1474 (September 7, 2006): 1681–87. http://dx.doi.org/10.1098/rstb.2006.1897.

Full text

Abstract:

Over 130 molecules have been identified in the interstellar gas and circumstellar shells, the largest among them is a carbon chain with 13 atoms and molecular weight of 147 (twice that of the simplest amino acid glycine). The high reliability of astronomical identifications, as well as the fairly accurate quantitative analysis which can often be achieved, is emphasized. Glycine itself has been claimed, but a recent analysis indicates that few, if any, of the astronomical radio lines attributed to glycine are actually from that molecule. Polycyclic aromatic hydrocarbons (PAHs) have long been proposed as the source of the unidentified infrared bands between 3 and 16 μm, but no single PAH has been identified in space, partly because PAHs generally have weak or non-existent radio spectra. A remarkable exception is the non-planar corannulene molecule (C 20 H 10 ) that has a strong radio spectrum; in the rich molecular cloud TMC-1, it is found that less than 10 −5 of the carbon is contained in this molecule, suggesting that PAHs are not the dominant large molecules in the interstellar gas, as has been claimed. Owing to inherent spectroscopic limitations, determining the structures of the large molecules in space may require capture of the dust grains, which are continually entering the outer Solar System.

APA, Harvard, Vancouver, ISO, and other styles

3

Balucani, Nadia. "Gas-phase prebiotic chemistry in extraterrestrial environments." Proceedings of the International Astronomical Union 5, H15 (November 2009): 682–83. http://dx.doi.org/10.1017/s1743921310010938.

Full text

Abstract:

AbstractA variety of molecular species up to complex polyatomic molecules/radicals have been identified in many extraterrestrial gaseous environments, including interstellar clouds, cometary comae and planetary atmospheres. Amongst the identified molecules/radicals, a large percentage are organic in nature and encompass also prebiotic molecules. Different types of microscopic processes are believed to be involved in their formation, including surface processes, ion- and radical- molecule reactions. A thorough characterization of such a complex chemistry relies on a multi-disciplinary approach, where the observations are complemented by accurate chemical modeling. Unfortunately, a literature survey reveals that only a small percentage of the elementary reactions considered in the available models have been characterized in laboratory experiments. In this contribution, a brief overview will be given of recent experimental techniques that have allowed us to reach a better description of neutral-neutral gas-phase reactions, which might be responsible for the formation of simple prebiotic molecules.

APA, Harvard, Vancouver, ISO, and other styles

4

Chandru, Mamajanov, Cleaves, and Jia. "Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry." Life 10, no. 1 (January 19, 2020): 6. http://dx.doi.org/10.3390/life10010006.

Full text

Abstract:

A variety of organic chemicals were likely available on prebiotic Earth. These derived from diverse processes including atmospheric and geochemical synthesis and extraterrestrial input, and were delivered to environments including oceans, lakes, and subaerial hot springs. Prebiotic chemistry generates both molecules used by modern organisms, such as proteinaceous amino acids, as well as many molecule types not used in biochemistry. As prebiotic chemical diversity was likely high, and the core of biochemistry uses a rather small set of common building blocks, the majority of prebiotically available organic compounds may not have been those used in modern biochemistry. Chemical evolution was unlikely to have been able to discriminate which molecules would eventually be used in biology, and instead, interactions among compounds were governed simply by abundance and chemical reactivity. Previous work has shown that likely prebiotically available α-hydroxy acids can combinatorially polymerize into polyesters that self-assemble to create new phases which are able to compartmentalize other molecule types. The unexpectedly rich complexity of hydroxy acid chemistry and the likely enormous structural diversity of prebiotic organic chemistry suggests chemical evolution could have been heavily influenced by molecules not used in contemporary biochemistry, and that there is a considerable amount of prebiotic chemistry which remains unexplored.

APA, Harvard, Vancouver, ISO, and other styles

5

Brown, Ronald D. "Prebiotic Matter in Interstellar Molecules." Symposium - International Astronomical Union 112 (1985): 123–37. http://dx.doi.org/10.1017/s0074180900146431.

Full text

Abstract:

With the discovery of the first polyatomic molecules, NH3, H2O and H2CO in 1968/9 there was immediate speculation as to how far biological chemical evolution - from atoms to small carbon compounds of biological significance - could have occurred in the Galaxy. There was also potential conflict with the canonical scientific view of the origin of life, traceable to the production of simple bio-molecules from the influence of energetic atmospheric events on the simple gaseous mixture (CH4, H2, H2O and NH3) presumed to compose the atmosphere of the very young Earth.

APA, Harvard, Vancouver, ISO, and other styles

6

Winnewisser, Gisbert. "Interstellar Molecules of Prebiotic Interest." International Astronomical Union Colloquium 161 (January 1997): 5–22. http://dx.doi.org/10.1017/s0252921100014573.

Full text

Abstract:

AbstractThe field of interstellar molecules is reviewed with special consideration of molecules which are of potential biological interest. At present more than 110 interstellar molecules have been identified in interstellar clouds and circumstellar envelopes. The more complex molecules are found in the dense cores which are often the sites of active star formation. These locations represent prime targets for the search of larger molecules such as glycine and possibly other amino acids. However, in the list of detected interstellar molecules still many simple hydrides are missing, e.g. SH, PH, PH2, etc., which constitute the building blocks for larger molecules and biomolecules. With the technological opening of the terahertz region to both laboratory and interstellar spectroscopy, great scientific advances are to expected such as the direct detection of the low energy bending vibrations of larger (linear) molecules or the ring-puckering motion of larger ring molecules like the polycyclic (multiring) aromatic hydrocarbons, which might shed new light on the assignment of the «unidentified infrared» features or even on the diffuse visible interstellar bands (DIBs).

APA, Harvard, Vancouver, ISO, and other styles

7

Villicana-Pedraza, I., R. Walterbos, F. Carreto-Parra, J. Ott., E. Momjian, A. Thelen, A. Ginsburg, et al. "Preliminary results from prebiotic molecules with ALMA in the era of artificial intelligence." Proceedings of the International Astronomical Union 15, S352 (June 2019): 248–50. http://dx.doi.org/10.1017/s1743921319009220.

Full text

Abstract:

AbstractStudy of the composition from diverse sources of the Universe helps to us to understand their evolution. Molecular spectroscopy provides detailed information of the observed objects. We present a small study of the starburst NGC 253 with ALMA at 1mm. We detect the prebiotic molecules NH2CHO, and CNCHO. We obtain the integrated intensity maps and abundances of HNCO, CH3OH, H3O+ and CH3C2H. We propose the use of Artificial Intelligence for big data to find prebiotic molecules in galaxies.

APA, Harvard, Vancouver, ISO, and other styles

8

Micca Longo, Gaia, Luca Vialetto, Paola Diomede, Savino Longo, and Vincenzo Laporta. "Plasma Modeling and Prebiotic Chemistry: A Review of the State-of-the-Art and Perspectives." Molecules 26, no. 12 (June 16, 2021): 3663. http://dx.doi.org/10.3390/molecules26123663.

Full text

Abstract:

We review the recent progress in the modeling of plasmas or ionized gases, with compositions compatible with that of primordial atmospheres. The plasma kinetics involves elementary processes by which free electrons ultimately activate weakly reactive molecules, such as carbon dioxide or methane, thereby potentially starting prebiotic reaction chains. These processes include electron–molecule reactions and energy exchanges between molecules. They are basic processes, for example, in the famous Miller-Urey experiment, and become relevant in any prebiotic scenario where the primordial atmosphere is significantly ionized by electrical activity, photoionization or meteor phenomena. The kinetics of plasma displays remarkable complexity due to the non-equilibrium features of the energy distributions involved. In particular, we argue that two concepts developed by the plasma modeling community, the electron velocity distribution function and the vibrational distribution function, may unlock much new information and provide insight into prebiotic processes initiated by electron–molecule collisions.

APA, Harvard, Vancouver, ISO, and other styles

9

Miller, Stanley L. "Endogenous synthesis of prebiotic organic molecules." Origins of Life and Evolution of the Biosphere 26, no. 3-5 (October 1996): 201–2. http://dx.doi.org/10.1007/bf02459712.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Van Loo, Jan. "The specificity of the interaction with intestinal bacterial fermentation by prebiotics determines their physiological efficacy." Nutrition Research Reviews 17, no. 1 (June 2004): 89–98. http://dx.doi.org/10.1079/nrr200377.

Full text

Abstract:

The concept of prebiotic food ingredients is an important recent development in nutrition. The concept has attracted a great deal of attention, and many food ingredients (mainly dietary carbohydrates) have been claimed to be ‘prebiotic’. It is emphasised that in order to be called prebiotic, a compound should be: (1) non-digestible; (2) fermentable; (3) fermentable in a selective way. These properties should be demonstrated in human volunteers in at least two independent dietary intervention trials. On the basis of published and unpublished results, it is shown in the present paper that the way in which a prebiotic influences intestinal fermentation is the key to its physiological properties. This statement is illustrated mainly by considering an established group of prebiotics, the β(2–1) fructans. These linear molecules show a strong discontinuity in physicochemical properties as the chains become longer. The β(2–1) fructans with a chain length of up to ten monomer units are very soluble and are particularly ‘bifidogenic’. Longer chains (ten to sixty-five monomer units) are poorly soluble in water, they have less pronounced bifidogenic properties, and they are fermented more slowly. It was observed that a combination of short-chain and long-chain fructans (Synergy1) is physiologically (for example, increasing mineral absorption, suppressing carcinogenesis, modulating lipid metabolism, etc) more active than the individual fractions. A possible mechanism is described in the present review. From an in-depth overview of the literature it is confirmed that for prebiotic action, the ‘selectivity principle’ for intestinal fermentation is determinative for the type and for the efficiency of physiological activity. It is confirmed that prebiotics act through their influence on intestinal fermentation.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Prebiotic molecules"

1

Widicus, Weaver Susanna Leigh Beauchamp Jesse L. "Rotational spectroscopy and observational astronomy of prebiotic molecules /." Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-05162005-153745.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Laporte, Sara. "The Electric Field at an Oxide Surface - Impact on Reactivity of Prebiotic Molecules." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066314/document.

Full text

Abstract:

Les surfaces minérales auraient eu un rôle important dans la chimie prébiotique, grace à leurs propriétés catalytiques, tel que le champ électrique de surface. Dans ce travail, le champ électrique à la surface de MgO et à l'interface MgO/eau est étudié en utilisant la dynamique moléculaire ab-initio. Ce champ est local et intense, de l'ordre de V/Å, même lorque la surface est recouverte d'eau. Une réaction prébiotique modèle est ensuite étudiée, à la surface de MgO : une molécule de monoxide de carbone et une molécule d'eau, donnant une molécule d'acide formique. En utilisant la métadynamique, et sans connaissance des états de transition en amont, des chemins de réaction sont trouvés et leurs profils d 'énergie libre sont calculés à 5 kcal/mol près, avec l'aide d'un échantillonage dans l'espace des configurations par « umbrella sampling ». La présence de la surface minérale stabilise l'acide formique d'au moins 15 kcal/mol par-rapport au cas en solution sans surface. La même réaction a aussi été étudiée sous un champ électrique homogène de 0,3 V/Å, afin de comparer l'effet de ce champ à l'effet du champ de surface sur le paysage d'énergie libre. Le champ homogène stabilise aussi le produit, et l'acide formique se trouve orienté dans la direction du champ électrique de surface ainsi que dans le champ électrique homogène. Ce travail montre que les conditions proche d'une surface minérale, même sans adsorption directe, peut modifier considerablement le paysage d'énergie libre de réactions chimiques, ce qui pourrait avoir de l'importance en chimie prébiotique
Mineral surfaces are thought to be of importance to prebiotic chemistry due to their catalytic properties, which include a strong electric field at the interface. In this work the electric field at the surface of MgO and at the interface of MgO and water is studied through ab-initio molecular dynamics. The spontaneous electric field from the surface is found to be local and intense, on the order of V/Å, even when completely covered with water. A model prebiotic reaction is then studied on the model MgO surface : carbon monoxide and water yielding formic acid. Using metadynamics, reaction pathways were found with no a priori knowledge of the transition states, and umbrella sampling was then used to compute free energy landscapes to about 5 kcal/mol accuracy. The presence of the mineral surface was found to stabilise formic acid by at least 15 kcal/mol compared to the bulk case. The reaction was also studied in solution with an applied electric field of 0.3 V/Å, in order to estimate to impact of the surface electric field on the free energy landscape. The field is also found to stabilise the product, and formic acid is found to have a preferred orientation in the direction of both the applied electric field and the surface electric field. This work shows that near surface conditions (without direct adsorption) can significantly alter the free energy landscapes of chemical reactions, in a way which could be of importance for prebiotic chemistry

APA, Harvard, Vancouver, ISO, and other styles

3

Neish, Catherine Dorothy. "Formation of Prebiotic Molecules in Liquid Water Environments on the Surface of Titan." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194180.

Full text

Abstract:

Saturn’s moon Titan represents a unique locale for studying prebiotic chemistry. Reactions occurring in its thick nitrogen-methane atmosphere produce a wide variety of carbon, hydrogen, and nitrogen containing organic molecules. If these molecules are exposed to liquid water, they may react further to produce oxygen-containing species, a key step in the formation of terrestrial biomolecules. On average, Titan's surface is too cold for liquid water. However, models indicate that melting caused by impacts and/or cryovolcanism may lead to its episodic availability. One possible cryovolcanic dome, Ganesa Macula, was identified in early observations by the Cassini spacecraft. In this work, I estimate the height and morphology of this feature using a synthetic aperture radar (SAR) image. I then use a thermal conduction code to calculate the freezing timescale for an initially liquid dome, yielding freezing timescales of ~10² - 10⁵ years. To determine how far aqueous organic chemistry can proceed in liquid water environments on Titan, I measure the rate coefficients of Titan analogue organic molecules ("tholins") with low temperature aqueous solutions to produce oxygenated species. These reactions display first-order kinetics with half-lives between 0.4 and 7 days at 273 K (in water) and between 0.3 and 14 days at 253 K (in 13 wt. % ammonia-water). Tholin hydrolysis in aqueous solutions is thus very fast compared to the freezing timescales of impact melts and volcanic sites on Titan, which take hundreds to thousands of years to freeze. The fast incorporation of oxygen, along with new chemistry made available by the introduction of ammonia, may lead to the formation of molecules of prebiotic interest in these transient liquid water environments. This chemistry makes impact craters and cryovolcanoes important targets for future missions to Titan.

APA, Harvard, Vancouver, ISO, and other styles

4

Dioses, Castro Silvio, and Richard Korswagen. "Over the possible role of metal atom clusters in cosmochemistry and in the origin of life." Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100714.

Full text

Abstract:

We present here the hypothesis of a possible relationship between metal atom clusters and the formation of organic molecules in the interstellar medium and on small bodies as a possible pathway to the origin of such molecules. Two distinct stages are díscussed: a) the possible formation and presence of atom clusters in space and on the primitive Earth, and b) the synthesis of interstellar and terrestrial prebiotic organic molecules, a process in which metalclusters could be the active catalysts. The confirmatíon of these suggestions might be very important in arder to explain the presence of extra-terrestrial organic molecules in the interstellar medium, small bodies and planetary systems, and therefore would have great relevance in cosmochemistry and in the current theories about the origins of life.

APA, Harvard, Vancouver, ISO, and other styles

5

Morasch, Matthias [Verfasser], and Dieter [Akademischer Betreuer] Braun. "Accumulation, gelation, and crystallization of prebiotic molecules in a thermal gradient and deep UV Circular dichroism / Matthias Morasch ; Betreuer: Dieter Braun." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1210424290/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Vazart, Fanny. "Gas-phase formation of Complex Organic Models molecules in interstellar medium: computational investigations." Doctoral thesis, Scuola Normale Superiore, 2017. http://hdl.handle.net/11384/85813.

Full text

Abstract:

[excerpt form the abstract:] In the field of astro- and prebiotic chemistry, the building blocks of life, which are molecules composed of more than 6 atoms, are called Complex Organic Molecules (COMs). Their appearances on the early inorganic Earth is therefore one of the major issues faced by researchers interested in the origin of life. In this thesis, split into three parts, the main purpose is to show how different COMs are formed in interstellar medium (ISM), using computational chemistry. The first part focuses mainly on preliminary studies aiming at evaluating the appropriate level of theory to use to perform studies of formation reactions. First, a comprehensive benchmark of C≡N stretching vibrations computed at harmonic and anharmonic levels is reported with the goal of proposing and validating a reliable computational strategy to get accurate results for this puzzling vibrational mode, involved in biological molcules, without any ad hoc scaling factor.

APA, Harvard, Vancouver, ISO, and other styles

7

Bean, Heather D. "Prebiotic synthesis of nucleic acids." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/28259.

Full text

Abstract:

Thesis (M. S.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2008.
Committee Chair: Hud, Nicholas V.; Committee Member: Fox, Ronald F.; Committee Member: Lynn, David G.; Committee Member: Powers, James C.; Committee Member: Wartell, Roger M.; Committee Member: Williams, Loren D.

APA, Harvard, Vancouver, ISO, and other styles

8

Aylward, Nigel Nunn. "Studies of electronic and structural properties of molecular clusters of prebiotic importance." Thesis, Queensland University of Technology, 2006. https://eprints.qut.edu.au/16328/1/Nigel_Aylward_Thesis.pdf.

Full text

Abstract:

This thesis applies the ab initio techniques of computational chemistry to studies of molecular clusters containing covalent (strong) or van der Waals (weak) bonds formed in chemistry and biochemistry in the temperature range 10-300 K. Van derWaals complexes with an enthalpy of formation from reactants of less than 25 kJ mol-1 and covalent clusters are described in this thesis. The first group of van der Waals complexes involved the molecule carbon monoxide that possesses a small permanent dipole that could lead to dipole - induced dipole interaction and dipole - dipole interaction with another reactant in addition to dispersion. The substrates investigated were methanimine and cyanogen where endergonic unstable molecules were formed, and the clustering of carbon monoxideon a porphin surface leading to the formation of carbon - carbon fragments. TheFaraday effect was invoked to suggest that this was the original method by which thechirality of the D-sugars was selected. Coordination of imino-compounds on thesame surface involving induction and electrostatic interactions could lead to the preferential formation of L-aziridones, hydrolysable to L-amino-acids.The preferred formation of D-ribose, and the more stable D-2-deoxyribose, andnucleotides polymerisable to deoxyribonucleic acids was described. The second group of van der Waals complexes involved the polymerisation of acetylene molecules, to di- and tri-acetylene complexes where the exchange interaction involved the quadrupole moment of the acetylene radical reacting with acetylene or diacetylene. The reaction of carbon monoxide was extended to include its interaction with diacetylene. The entire potential energy surface for the interaction with diacetylene was investigated. The reaction was shown to be endergonic to produce a reactive species, here postulated to rearrange with a reasonable activation energy toform an aldehyde. The energetics of the formation of diacetylene, triacetylene andhigher polymers was briefly investigated. The reactivity of the acetylene polymeraldehydes with other substrates was briefly investigated. This work has apparently laid a firm basis both, qualitative and quantitative, tounderstand some of the weakest interactions in nature involving the simplest ofreactions that have been important in atmospheric chemistry.

APA, Harvard, Vancouver, ISO, and other styles

9

Aylward, Nigel Nunn. "Studies of electronic and structural properties of molecular clusters of prebiotic importance." Queensland University of Technology, 2006. http://eprints.qut.edu.au/16328/.

Full text

Abstract:

This thesis applies the ab initio techniques of computational chemistry to studies of molecular clusters containing covalent (strong) or van der Waals (weak) bonds formed in chemistry and biochemistry in the temperature range 10-300 K. Van derWaals complexes with an enthalpy of formation from reactants of less than 25 kJ mol-1 and covalent clusters are described in this thesis. The first group of van der Waals complexes involved the molecule carbon monoxide that possesses a small permanent dipole that could lead to dipole - induced dipole interaction and dipole - dipole interaction with another reactant in addition to dispersion. The substrates investigated were methanimine and cyanogen where endergonic unstable molecules were formed, and the clustering of carbon monoxideon a porphin surface leading to the formation of carbon - carbon fragments. TheFaraday effect was invoked to suggest that this was the original method by which thechirality of the D-sugars was selected. Coordination of imino-compounds on thesame surface involving induction and electrostatic interactions could lead to the preferential formation of L-aziridones, hydrolysable to L-amino-acids.The preferred formation of D-ribose, and the more stable D-2-deoxyribose, andnucleotides polymerisable to deoxyribonucleic acids was described. The second group of van der Waals complexes involved the polymerisation of acetylene molecules, to di- and tri-acetylene complexes where the exchange interaction involved the quadrupole moment of the acetylene radical reacting with acetylene or diacetylene. The reaction of carbon monoxide was extended to include its interaction with diacetylene. The entire potential energy surface for the interaction with diacetylene was investigated. The reaction was shown to be endergonic to produce a reactive species, here postulated to rearrange with a reasonable activation energy toform an aldehyde. The energetics of the formation of diacetylene, triacetylene andhigher polymers was briefly investigated. The reactivity of the acetylene polymeraldehydes with other substrates was briefly investigated. This work has apparently laid a firm basis both, qualitative and quantitative, tounderstand some of the weakest interactions in nature involving the simplest ofreactions that have been important in atmospheric chemistry.

APA, Harvard, Vancouver, ISO, and other styles

10

Hoffman, Jessie Baldwin. "PCB DISRUPTION OF GUT AND HOST HEALTH: IMPLICATIONS OF PREBIOTIC NUTRITIONAL INTERVENTION." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/25.

Full text

Abstract:

Exposure to environmental pollutants poses numerous risk factors for human health, including increasing incidence of cardiovascular disease and diabetes. Persistent organic pollutants, such as polychlorinated biphenyls (PCBs) have been strongly linked to the development of these chronic inflammatory diseases and the primary route of exposure is through consumption of contaminated food products. Thus, the gastrointestinal tract is susceptible to the greatest levels of these pollutants and is an important facet to study. The first two hypotheses of this dissertation tested that exposure to PCBs disrupts gut microbiota directly (in vitro) and within a whole body system. PCB exposure disrupted microbial metabolism and production of metabolites (i.e. short chain fatty acids) in vitro. These disruptions in microbial populations were consistent in our mouse model of cardiometabolic disease, where we observed reductions in microbial diversity, an increase in the putative pro-inflammatory ratio of Firmicutes to Bacteroidetes, and reductions in beneficial microbial populations in exposed mice. Furthermore, observed greater inflammation was observed both within the intestines and peripherally in PCB exposed mice as well as disruptions in circulating markers associated with glucose homeostasis. Nutritional interventions high in prebiotic dietary fiber such as inulin may be able to attenuate the toxic effects of pollutant exposure. To test the hypothesis that consumption of the prebiotic inulin can decrease PCB-induced disruption in gut microbial and metabolic homeostasis, LDLr-\- mice were fed a diet containing inulin and exposed to PCB 126. Mice fed an inulin-containing diet and exposed to PCBs exhibited improved glucose tolerance, lower hepatic inflammation and steatosis, and distinct differences in gut microbial populations. Overall, these data suggests that nutritional intervention, specifically prebiotic consumption, may reduce pollutant-induced disease risk.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Prebiotic molecules"

1

Tze-Fei, Wong J., and Lazcano Antonio, eds. Prebiotic evolution and astrobiology. Austin, Tex: Landes Bioscience, 2009.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Peter, Walde, and Boiteau L. 1967-, eds. Prebiotic chemistry: From simple amphiphiles to protocell models. Berlin: Springer, 2005.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

3

1964-, Zaikowski Lori, Friedrich Jon M, and American Chemical Society Meeting, eds. Chemical evolution across space and time: From Big Bang to prebiotic chemistry. Washington, D.C: American Chemical Society, 2007.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

4

Menor-Salván, César. Prebiotic Chemistry and Chemical Evolution of Nucleic Acids. Springer, 2019.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

5

Menor-Salván, César. Prebiotic Chemistry and Chemical Evolution of Nucleic Acids. Springer, 2018.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

6

Douglas, Kenneth. DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology. Taylor & Francis Group, 2016.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

7

Douglas, Kenneth. DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology. Taylor & Francis Group, 2016.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

8

DNA Nanoscience: From Prebiotic Origins to Emerging Nanotechnology. Taylor & Francis Group, 2016.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

9

Nishimura, S. Comprehensive Natural Products Chemistry : Prebiotic Chemistry, Molecular Fossils, Nucleosides and RNA. Pergamon Pr, 1999.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

10

Nishimura, S. Comprehensive Natural Products Chemistry : Prebiotic Chemistry, Molecular Fossils, Nucleosides and RNA. Pergamon Pr, 1999.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Prebiotic molecules"

1

Brown, Ronald D. "Prebiotic Matter in Interstellar Molecules." In The Search for Extraterrestrial Life: Recent Developments, 123–37. Dordrecht: Springer Netherlands, 1985. http://dx.doi.org/10.1007/978-94-009-5462-5_19.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Civiš, Svatopluk, Martin Ferus, and Antonín Knížek. "Additional Views on Prebiotic Molecules." In SpringerBriefs in Molecular Science, 69–76. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24032-5_4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Ohishi, Masatoshi. "Prebiotic Complex Organic Molecules in Space." In Astrobiology, 11–21. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3639-3_2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Ziurys, Lucy M. "Interstellar Molecules and Their Prebiotic Potential." In Handbook of Astrobiology, 147–63. Boca Raton, Florida : CRC Press, [2019]: CRC Press, 2018. http://dx.doi.org/10.1201/b22230-13.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Greenberg, J. Mayo, and Celia X. Mendoza-Gómez. "Interstellar Dust Evolution: A Reservoir of Prebiotic Molecules." In The Chemistry of Life’s Origins, 1–32. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1936-8_1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Miller, Stanley L. "The Prebiotic Synthesis of Organic Molecules and Polymers." In Advances in Chemical Physics, 85–107. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470142790.ch7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Harris, Kelley, and Irene A. Chen. "Mathematical Models of Prebiotic Replication of Informational Molecules." In Cellular Origin, Life in Extreme Habitats and Astrobiology, 67–88. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2941-4_4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Germain, Aurèle, Marta Corno, and Piero Ugliengo. "Computing Binding Energies of Interstellar Molecules by Semiempirical Quantum Methods: Comparison Between DFT and GFN2 on Crystalline Ice." In Computational Science and Its Applications – ICCSA 2021, 632–45. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-86976-2_43.

Full text

Abstract:

AbstractInterstellar Grains (IGs) spread in the Interstellar Medium (ISM) host a multitude of chemical reactions that could lead to the production of interstellar Complex Organic Molecules (iCOMs), relevant in the context of prebiotic chemistry. These IGs are composed of a silicate-based core covered by several layers of amorphous water ice, known as a grain mantle. Molecules from the ISM gas-phase can be adsorbed at the grain surfaces, diffuse and react to give iCOMs and ultimately desorbed back to the gas phase. Thus, the study of the Binding Energy (BE) of these molecules at the water ice grain surface is important to understand the molecular composition of the ISM and its evolution in time. In this paper, we propose to use a recently developed semiempirical quantum approach, named GFN-xTB, and more precisely the GFN2 method, to compute the BE of several molecular species at the crystalline water ice slab model. This method is very cheap in term of computing power and time and was already showed in a previous work to be very accurate with small water clusters. To support our proposition, we decided to use, as a benchmark, the recent work published by some of us in which a crystalline model of proton-ordered water ice (P-ice) was adopted to predict the BEs of 21 molecules relevant in the ISM. The relatively good results obtained confirm GFN2 as the method of choice to model adsorption processes occurring at the icy grains in the ISM. The only notable exception was for the CO molecule, in which both structure and BE are badly predicted by GFN2, a real pity due to the relevance of CO in astrochemistry.

APA, Harvard, Vancouver, ISO, and other styles

9

Despois, Didier, and Hervé Cottin. "Comets: Potential Sources of Prebiotic Molecules for the Early Earth." In Lectures in Astrobiology, 289–352. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/10913406_9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ferris, J. P. "The Prebiotic Synthesis and Replication of RNA Oligomers: The Transition from Prebiotic Molecules to the RNA World." In Self-Production of Supramolecular Structures, 89–98. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0754-9_7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Prebiotic molecules"

1

Omer, Markovitch, and Lancet Doron. "Prebiotic Evolution of Molecular Assemblies: From Molecules to Ecology." In European Conference on Artificial Life 2013. MIT Press, 2013. http://dx.doi.org/10.7551/978-0-262-31709-2-ch020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Puzzarini, Cristina, Vincenzo Barone, Luca Dore, Mattia Melosso, and Lorenzo Spada. "PREBIOTIC MOLECULES IN INTERSTELLAR SPACE: ROTATIONAL SPECTROSCOPY OF CYANOMETHANIMINE AND ETHANIMINE." In 73rd International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2018. http://dx.doi.org/10.15278/isms.2018.tl03.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Hays, Brian, Susanna Widicus Weaver, and Althea Roy. "MILLIMETER/SUBMILLIMETER SPECTROSCOPY OF PREBIOTIC MOLECULES FORMED FROM THE O(1D) INSERTION INTO METHYLAMINE." In 69th International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2014. http://dx.doi.org/10.15278/isms.2014.ta05.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Puzzarini, Cristina, Silvia Alessandrini, Luca Bizzocchi, and Mattia Melosso. "PREBIOTIC MOLECULES IN INTERSTELLAR SPACE: THE ROLE OF ROTATIONAL SPECTROSCOPY AND QUANTUM-CHEMICAL CALCULATIONS." In 2022 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2022. http://dx.doi.org/10.15278/isms.2022.rn06.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Lolur, P., M. Rahm, M. Skogh, L. García-Álvarez, and G. Wendin. "Benchmarking the variational quantum eigensolver through simulation of the ground state energy of prebiotic molecules on high-performance computers." In MIPT (PHYSTECH) - QUANT 2020. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0054915.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Schultz, Chase, Susanna Widicus Weaver, and Hayley Bunn. "MILLIMETER AND SUBMILLIMETER SPECTRUM OF GLYCOLIC AICD AND GLYCOLAMIDE: INVESTIGATION OF ORGANIC ACID AND AMIDE PREBIOTIC TARGET MOLECULES IN THE INTERSTELLAR MEDIUM." In 2020 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2020. http://dx.doi.org/10.15278/isms.2020.wf09.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Greenberg, J. Mayo. "Prebiotic chiral molecules created in interstellar dust and preserved in comets, comet dust, and meteorites: an exogenous source of life's origins." In Optical Science, Engineering and Instrumentation '97, edited by Richard B. Hoover. SPIE, 1997. http://dx.doi.org/10.1117/12.278810.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Widicus Weaver, Susanna. "PREBIOTIC ASTROCHEMISTRY IN THE "THz-GAP"." In 2020 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2020. http://dx.doi.org/10.15278/isms.2020.ma01.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Widicus Weaver, Susanna. "PREBIOTIC ASTROCHEMISTRY IN THE "THz-GAP"." In 2021 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2021. http://dx.doi.org/10.15278/isms.2021.ma01.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Schultz, Chase, Susanna Widicus Weaver, and Hayley Bunn. "EXTENSION OF THE MILLIMETER AND SUBMILLIMETER SPECTRUM OF GLYCOLIC ACID: ROTATIONAL SPECTROSCOPIC STUDY OF A POTENTIAL PREBIOTIC INTERSTELLAR MOLECULE." In 2022 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2022. http://dx.doi.org/10.15278/isms.2022.wn09.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!