Relevant bibliographies by topics / Pre-implantation embryo

Academic literature on the topic 'Pre-implantation embryo'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Pre-implantation embryo"

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Niakan, K. K., J. Han, R. A. Pedersen, C. Simon, and R. A. R. Pera. "Human pre-implantation embryo development." Development 139, no. 5 (February 7, 2012): 829–41. http://dx.doi.org/10.1242/dev.060426.

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Flores, Diana, Manoj Madhavan, Savannah Wright, and Ripla Arora. "Mechanical and signaling mechanisms that guide pre-implantation embryo movement." Development 147, no. 24 (November 6, 2020): dev193490. http://dx.doi.org/10.1242/dev.193490.

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ABSTRACTHow a mammalian embryo determines and arrives at its attachment site has been studied for decades, but our understanding of this process is far from complete. Using confocal imaging and image analysis, we evaluate embryo location along the longitudinal oviductal-cervical axis of murine uteri. Our analysis reveals three distinct pre-implantation phases: embryo entry, unidirectional movement of embryo clusters and bidirectional scattering and spacing of embryos. We show that unidirectional clustered movement is facilitated by a mechanical stimulus of the embryo and is regulated by adrenergic uterine smooth muscle contractions. Embryo scattering, on the other hand, depends on embryo-uterine communication reliant on the LPAR3 signaling pathway and is independent of adrenergic muscle contractions. Finally, we demonstrate that uterine implantation sites in mice are neither random nor predetermined but are guided by the number of embryos entering the uterine lumen. These studies have implications for understanding how embryo-uterine communication is key to determining an optimal implantation site necessary for the success of a pregnancy.
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Morris, D. G., P. Humpherson, H. J. Leese, and J. M. Sreenan. "Protein and energy metabolism in the pre-implantation cattle embryo." BSAP Occasional Publication 26, no. 2 (September 2001): 443–46. http://dx.doi.org/10.1017/s0263967x0003408x.

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AbstractThere is no information on the metabolism of the cattle embryo during the period from day 8 to 16 a period of greatest embryonic loss. In this study the rate of protein synthesis and phosphorylation was measured in 13 to 15 day old cattle embryos. The rate of glucose utilisation and amino acid uptake/efflux by day 14 to 16 embryos was also measured. Protein synthesis and phosphorylation activity when expressed per unit of protein decreased with increasing embryo size and age. Similarly the rate of glucose utilisation was greatest for the earlier day 14 embryos. Embryos differed in their requirement for different amino acids. The pattern of uptake/efflux was similar to that of the earlier day 7 embryo. This study suggests that the metabolic rate of cattle embryos expressed per unit of protein content tends to decrease with increasing age and size from the initial burst of activity at day 13 around the time that expansion of the embryo begins.
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Rajhans, R., G. S. Kumar, and G. T. Sharma. "292 EXPRESSION PROFILES OF STRESS AND METABOLIC MARKER GENES DURING IN VITRO PRODUCTION OF BUFFALO (BUBALUS BUBALIS) EMBRYOS." Reproduction, Fertility and Development 18, no. 2 (2006): 253. http://dx.doi.org/10.1071/rdv18n2ab292.

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An increased understanding of the pre-implantation embryo developmental stage, with respect to physiological interaction of embryo with its micromilieu both in vivo and in vitro, is imperative to comprehend the events of pre-implantation development.The objective of the present study was to examine the temporal expression of heat shock protein 70 (Hsp-70) and glucose transporter 1 (Glut1) genes in pre-implantation-stage buffalo embryos produced under the standard in vitro production (IVP) system. Embryos were produced from slaughterhouse ovaries employing standard in vitro embryo production protocol, and presumptive zygotes produced following IVM/IVF were cultured in vitro in mSOF under mineral oil; FCS (10%) was added at 48 h post-insemination (hpi).The time series of development at stages being zygote (18-20 hpi), 2-1 cell (48 hpi), 8-16 cell (94-96 hpi), morula (120-144 hpi), and blastocyst (168-192 hpi), pre-implantation embryos conforming to the above developmental pattern were considered as 'fast-cleaving embryos', and all the embryos that did not conform to the above developmental timing were regarded as 'slow-cleaving embryos'. Pools of immature oocytes (IM, 120), Matured oocytes (MO, 120), 8-16 cell stages (8-16, 70), morula (M, 28), and blastocyst (B, 9) were collected and prepared for total RNA isolation and RT-PCR for the specific transcripts, with �-actin as loading control. The total RNA content ranged from 2.5 to 5.0 ng per oocyte/embryo. Presence of Hsp 70 and Glut1 gene transcripts was assessed in different stages of buffalo pre-implantation embryos using primers designed from bovine Hsp 70 and Glut1 by using the OLIGO program. RT was standardized using the embryo equivalent of 1-10 oocytes/embryo as the template as described by Arcellana-Panlilio and Schultz 1993 (Methods Enzymol. 225, 303-328) with PCR conditions being 59�C and 62�C for 45 s with 39 cycles for Glut1 and Hsp 70 gene transcripts, respectively. Amplicons were subjected to restriction digestion and sequencing (Acc. No. AJ812563, AJ812564). The expression of Hsp 70 throughout pre-implantation development in the fast-cleaving embryos indicated their maternal and zygotic origin, but transcripts of the Hsp 70 gene, represented by a single 488-bp amplicon, were not detected in slow-cleaving embryos, suggesting altered zygotic expression. Glut1 expression was prominent from the 8-16 cell stage, indicating a metabolic shift from pyruvate to glucose after the pre-compaction stage. For slow-cleaving embryos, transcripts of the Glut1 gene, represented by a single 327-bp amplicon, were absent during morula- and blastocyst-stage embryos, indicating the poor developmental competence of these embryos, which morphologically appeared normal. These transcription patterns reflect the embryonic response to the in vitro culture conditions and also correlate with the embryo quality and the speed of development of the pre-implantation buffalo (Bubalus bubalis) embryos.
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O'Neill, C. "013.The regulation of survival of the pre-implantation embryo." Reproduction, Fertility and Development 16, no. 9 (2004): 13. http://dx.doi.org/10.1071/srb04abs013.

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There are many aspects of the regulation of the growth and survival of the pre-implantation embryo that remain enigmatic. The increasing production of such embryos by assisted reproductive technologies (ART) in human medicine, animal production and conservation biology has highlighted the relatively poor viability of such embryos. Many embryos fail to survive past the normal time of implantation. Population biology theory predicts that any circumstance that results in high death rates within a population creates a potential for genetic selection. This occurs if the surviving individuals have a genetic make up that preferentially favours survival. Since ART clearly favours the survival of some embryos over others, it is a high priority to develop a sound understanding of those factors that normally govern embryo survival and how they may be affected by ART. It raises the question, do embryos that survive ART have a genetic make up that favours their survival compared to the proportion of the population that does not survive? It is now demonstrated that autocrine and paracrine factors are essential for embryo survival and that these act via the 1-o-phosphatidylinositol-3-kinase (PI3K) survival signalling pathway (1). PI3K activates many downstream pro-survival and anti-apoptotic mediators. ART changes the expression of some of these mediators. Pharmacological and genetic moderation of their expression can influence embryo survival, highlighting potential targets for genetic selection through ART. Studies in appropriate models will allow rational approaches to safety assessment of ART and spawn new strategies for media and procedural design. (1) Lu, D. P., Chandrakanthan, V., Cahana, A., Ishii, S., O'Neill, C. (2004) J. Cell Sci. 117, 1567–1576.
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Matsumoto, K., A. Uenoyama, T. Matsuoka, K. Saeki, Y. Hosoi, and A. Iritani. "228 EXPRESSION OF zag1 IN MOUSE PRE-IMPLANTATION EMBRYOS." Reproduction, Fertility and Development 17, no. 2 (2005): 264. http://dx.doi.org/10.1071/rdv17n2ab228.

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Embryonic gene activation (EGA) first occurs during the second half of the mouse 1-cell embryo (Latham KE 1999 Int. Rev. Cytol. 193, 71–124). Moreover, precise regulation of EGA is considered to be essential for normal embryo development. To understand the molecular basis for the regulation of EGA, we have focused on the identification and functional characterization of genes activated at the late 1-cell stage of the mouse embryo. Recently, we have identified and isolated a novel gene, termed zag1 (zygotic activating gene 1), transcribed specifically at the EGA, using a fluoro-differential display method with oocytes and embryos at 15 h post-insemination. Messenger RNA of zag1 expressed at lower level in the oocyte than that in the embryo at 15 h post-imsemination. In this study, we investigated the potential function of zag1 by analysis of mRNA expression and protein distribution in mouse tissues and pre-implantation embryos. Nucleotide sequence analysis of zag1 cDNA revealed that the open reading frame of 1726 bps encodes a protein of 575 amino acids with a predicted molecular mass of 66 kDa. The deduced amino acid sequence indicated that zag1 protein might be a soluble protein with a bipartite nuclear targeting sequence, a NACHT NTP domain, and an APT/GTP binding site motif as a predicted functional domain. Two μg of Poly(A)+ RNA from various tissues of adult mice were subjected to Northern blot analysis using the mouse zag1 cDNA probe. We detected this gene abundantly expressed in mouse testis and ovary by approximately 2- to 3-fold compared with one in other mouse tissues (heart, liver, kidney, lung, brain, skeletal muscle, and spleen). zag1 transcript and protein, as assessed by RT-PCR and immunoblotting, respectively, were slightly present in ovulated oocytes, gradually decreased in the early 1-cell embryos, but re-expressed in the late 1-cell and early 2-cell stage embryos which coincided with the mouse EGA. Subsequent to microinjection of an expression vector encoding zag1-enhanced green fluorescent protein (EGFP), fused protein into male pronucleus of 1-cell embryos was detected in the nuclei of 2-cell embryos. These findings suggest that zag1 may be functionally associated with early embryonic development. This study was supported by a Grant-in-Aid for the 21st Century COE Program of the Japan MEXT, and by a grant from the Wakayama Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence of the JST.
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Li, Geng, Karam Khateeb, Erin Schaeffer, Bao Zhang, and Hasan Khatib. "Genes of the transforming growth factor-beta signalling pathway are associated with pre-implantation embryonic development in cattle." Journal of Dairy Research 79, no. 3 (June 12, 2012): 310–17. http://dx.doi.org/10.1017/s0022029912000210.

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One of the main factors affecting cattle fertility is pre-implantation development of the bovine embryo, which is a complex process regulated by various signal-transduction pathways. The transforming growth factor-β (TGF-β) signalling system, which is responsible for many biological processes including cell proliferation, differentiation and apoptosis, also is involved in embryo development. We hypothesized that altered expression of TGF-β genes in pre-implantation bovine embryos is associated with morphological abnormalities of these embryos. To test this hypothesis, we produced embryos in vitro and classified them at the blastocyst stage as either normally developed blastocysts or degenerates (growth-arrested embryos). The expression patterns of 25 genes from the TGF-β pathway were assessed using quantitative real time PCR. Ten genes showed differential expression between the two embryo groups, four genes displayed similar expressional profiles, and 11 genes had no detectable expression. An altered expression profile was statistically significant for 10 of the 14 expressed genes, and all were up-regulated in degenerate embryos vs. blastocysts. Furthermore, genomic association analysis of the cows from which embryos were produced revealed a significant association of ID3 and BMP4 polymorphisms—two of the most significant differentially expressed genes—with fertilization rate and blastocyst rate, respectively. Taken together, we conclude that TGF-β pathway genes, especially BMP4 and ID3 play a vital function in the regulation of pre-implantation embryo development at both embryo and maternal levels. Hence, these genes may be suitable as genetic markers for embryo development and fertility in cattle.
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Maganha, Juliana, Evelise de Souza Rocha, Marcos Antônio Fernandes Brandão, Vera Maria Peters, and Martha de Oliveira Guerra. "Embryo development alteration in rats treated with lapachol." Brazilian Archives of Biology and Technology 49, no. 6 (November 2006): 927–34. http://dx.doi.org/10.1590/s1516-89132006000700010.

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Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth retardation.
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Fu, Bo, Hong Ma, and Di Liu. "Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development." International Journal of Molecular Sciences 20, no. 3 (February 12, 2019): 790. http://dx.doi.org/10.3390/ijms20030790.

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Pre-implantation embryo development encompasses several key developmental events, especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous retroviruses (ERVs), which are regarded as “deleterious genomic parasites”, were previously considered to be “junk DNA”. However, it is now known that ERVs, with limited conservatism across species, mediate conserved developmental processes (e.g., ZGA). Transcriptional activation of ERVs occurs during the transition from maternal control to zygotic genome control, signifying ZGA. ERVs are versatile participants in rewiring gene expression networks during epigenetic reprogramming. Particularly, a subtle balance exists between ERV activation and ERV repression in host–virus interplay, which leads to stage-specific ERV expression during pre-implantation embryo development. A large portion of somatic cell nuclear transfer (SCNT) embryos display developmental arrest and ZGA failure during pre-implantation embryo development. Furthermore, because of the close relationship between ERV activation and ZGA, exploring the regulatory mechanism underlying ERV activation may also shed more light on the enigma of SCNT embryo development in model animals.
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Lutz, J., S. Johnson, K. Duprey, P. Taylor, H. Vivanco, M. Ponce-Salazar, M. Miguel, and C. Youngs. "7 Pregnancy from a vitrified-warmed alpaca pre-implantation embryo." Reproduction, Fertility and Development 32, no. 2 (2020): 128. http://dx.doi.org/10.1071/rdv32n2ab7.

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The alpaca (Vicugna pacos) is a ruminant livestock species in the South American camelid family. There are more than 9 million South American camelids globally that make important contributions to the livelihoods of rural farmers through conversion of low quality roughages to high quality food and fibre. Reproductive biotechnologies for alpacas are not well developed compared with those for other ruminant livestock species. In particular, embryo cryopreservation technologies are lacking. The objective of this study was to evaluate under field conditions a vitrification protocol originally developed for old world camels that we adapted for use in alpacas. Potential donors were evaluated for follicular development using a 7.5-MHz ultrasound probe. Hembras (sexually mature female alpacas) with ovarian follicles 7-10mm in diameter were behaviour tested to determine sexual receptivity, and receptive females were naturally mated to a proven herd sire. At the time of breeding, non-superovulated donors (n=4) received 30μg gonadorelin. Embryos were nonsurgically collected 7 days after breeding and handled at 20°C. Diameter of harvested embryos (n=4 quality grade 1 hatched expanded blastocysts) was measured using an eyepiece reticle. All recovered embryos were placed individually into 0.5-mL drops of vitrification solution (VS1: 1.4M glycerol) for 5min, 0.5-mL drops of VS2 (1.4 M glycerol + 3.6M ethylene glycol) for 5min, 0.05-mL drops of VS3 (3.4 M glycerol + 4.6M ethylene glycol) for 20s, and 0.05-mL drops of VS3 for 20s while loading into open-pulled straws (OPS). Each OPS was plunged directly into liquid nitrogen for storage for 29 days. At warming, each OPS was submerged into a 1-mL drop of warming solution 1 (WS1: 0.5M galactose) for 1min followed by 1min in WS2 (0.25 M galactose) for 5min before being incubated at 37°C in 5% CO2 in humidified air for 21h in 1mL of Syngro holding medium supplemented with 10% (vol/vol) alpaca serum. Embryos that grew during culture (n=2) were transferred individually into synchronous recipients, and embryos that did not appear to grow (n=2) were transferred together as a pair. Prior to embryo transfer, potential recipients were evaluated ultrasonographically as described previously. Hembras with ovarian follicles 7-10mm in diameter were behaviour tested, and sexually receptive females received 30μg gonadorelin 6 days before embryo transfer. Final selection of recipients (n=3) was based on presence of a corpus luteum and nonreceptive behaviour to a herd sire 24h before transfer. Pregnancy was detected ultrasonographically, and fetal heartbeat was detected 29 days post-transfer in one of the three recipients. Ultrasound at 177 days post-transfer revealed that the pregnancy, generated from a 400μm×375μm vitrified-warmed embryo that had grown in culture, was still ongoing. If this pregnancy results in the birth of a live cria (newborn alpaca), it would represent-to the best of our knowledge-the world's first cria born from a cryopreserved alpaca pre-implantation embryo. It would also demonstrate the potential utility of this protocol under field conditions.
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Dissertations / Theses on the topic "Pre-implantation embryo"

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Graham, Sarah Jane Lehar. "Novel molecular mechanisms in pre-implantation mouse embryo development." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708487.

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Wonnacott, Karen Elizabeth. "Fatty Acid Uptake in the Ruminant Ovary and Pre-Implantation Embryo." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503811.

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Spyropoulou, Isabella. "Studies of methods to improve human pre- and peri-implantation embryo development in vitro." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365394.

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Kurowski, Agata Maria. "The establishment and maintenance of the pluripotency network in the pre-implantation mouse embryo." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709248.

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Balasuriya, A. S. "An investigation of DNA integrity biomarkers in gametogenesis and pre-implantation embryo development to predict reproductive potential." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1416269/.

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Unsuccessful fertilization, aberrant embryo development, implantation failure and recurrent miscarriages can occur despite any obvious reasons during assisted reproduction. DNA fragmentation and aneuploidy in gametes have been implicated as a possible cause for infertility, but the use of DNA fragmentation tests is controversial. The SCD-FISH test claims to analyse DNA fragmentation and aneuploidy in the same cell. In this thesis SCD-FISH was compared to single FISH and SCD, which showed that SCD-FISH was an unreliable method to study these parameters. Sperm preparation techniques in assisted reproduction technologies (ART) potentially generate exogenous stresses that cause additional DNA damage. This study subjected mature sperm to environmental insults that normally occur during ART, and highlighted the significant increase in sperm DNA fragmentation due to heat, freezing and oxidative stress. Since it is not possible to investigate the level of DNA damage in the egg or sperm, and still maintain its viability for use in fertilization, DNA damage in cumulus and granulosa cells were studied. There was no relationship between DNA fragmentation in these cells and fertilization or pregnancy outcome. DNA fragmentation was significantly higher in cumulus than granulosa cells. Allegedly minimising DNA damage, GM-CSF is a component added to IVF culture media. Its effect on murine embryo DNA fragmentation was studied and it was found to have no significant effect. The exposure of human embryonic stem cells to pre-tested toxins and its impact on DNA fragmentation and aneuploidy, and the correlation between these two parameters were also investigated. These studies emphasise the belief that the introduction of DNA fragmentation assays to the clinical arena is premature as its role is unsubstantiated, the lack of a transparent relationship between DNA fragmentation and pregnancy outcome and the importance of minimising damage to sperm and embryos due to external stresses during laboratory research and ART. Overall, the aim of this thesis was to examine the hypotheses that DNA fragmentation, aneuploidy and phosphatidylserine translocation are potential biomarkers of reproductive potential that exist in variable degrees of at different stages of gametogenesis and preimplantation embryo development, and are susceptible to environmental stresses.
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Hanna, Carol Bailey McCormick. "Comparison of gene expression in pre-implantation bovine embryos either injected or transfected with a siRNA targeted against E-cadherin." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3048.

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Hughes, Jaime. "The effect of dietary omega-3 and -6 polyunsaturated fatty acids on ovine ovarian function and the pre-implantation embryo." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/11800/.

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There is considerable interest in the beneficial role of dietary polyunsaturated fatty acids (PUFA) on reproduction in ruminants. Detailed information regarding the mechanisms behind this beneficial effect is limited. The main objective of this thesis was to test the effects of dietary supplementation with omega-3 (n-3) or -6 (n-6) PUFA on gene expression, fatty acid (FA) composition and steroidogenesis in granulosa and theca cells and pre-implantation embryo development. A previous study in our laboratory reported increased follicular-fluid progesterone concentrations in ewes fed an n-3 compared to an n-6 PUFA-enriched diet, but detected no differential effect of n-3 and n-6 PUFA enriched high-density lipoproteins (HDL) on granulosa cell steroidogenesis in vitro. Also, n-6 PUFA enriched HDL reduced early embryo development, but in the absence of a net uptake of FA. In view of these observations it was hypothesised that (i) effects of n-3 PUFA on ovarian steroidogenesis are mediated by theca rather than granulosa cells and (ii) during embryo culture lipids are acquired solely from the albumin fraction of serum, so that albumin delivered n- 3 and n-6 PUFA would exert a greater differential effect on embryo development than either LDL or HDL delivered PUFA. Initial investigations into granulosa cell gene expression profiles using an ovine gonad-targeted cDNA macroarray were unsuccessful, highlighted by subsequent qRTPCR analysis. A thorough investigation confirmed that inconsistencies were due to poor array hybridisation. In vitro data confirmed that n-3 PUFA, via delivery by HDL, increase progesterone production solely in theca cells and that this is associated with an increase in STAR transcript expression. We also demonstrate that albumin is the only serum fraction that leads to a net uptake of FA during embryo culture. PUFA enriched serum and albumin accelerated the development of embryos and increased the yield of morphologically poorer quality blastocysts with increased transcript expression for the antioxidant enzyme SOD1. Important differential effects of n-3 and n-6 PUFA on ovarian steroidogenesis acting solely on theca cells are identified, but differentially effects of PUFA on embryo development are less apparent.
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Shaikly, Valerie Ruth. "An investigation into the factors associated with human pre-implantation embryo development and foetal maternal tolerance in the course of in vitro fertilization." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502139.

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Porchet, Nicolas. "Role of signaling pathays in cell-fate specification in the early mouse embryo." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7096.

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Lors du développement précoce de l’embryon de souris, divers évènements de spécification des destins cellulaires induisent la formation du blastocyste pré-implantatoire. Ces évènements sont majoritairement contrôlés par l’action de voies de signalisation activées via la fixation de molécules signal à la membrane de la cellule. L’activité de ces voies de signalisation permet la régulation de la transcription de gènes cible responsable de l’acquisition d’une identité cellulaire et de son arrangement sous forme de tissu. Ici je m’intéresse aux rôles des voies ACTIVINE/NODAL et βCATENIN dans la spécification de ces identités cellulaires lors de la formation du blastocyste de souris
During the early mouse embryogenesis, cell-fate specification events result in the formation of the pre-implantation blastocyst. Those events are mainly regulated by the action of signaling cascades activated upon fixation of the signaling molecules at the cell membrane. The activity of these signaling pathways allow the transcriptional regulation of a specific pool of genes responsible for cell-fate decisions and the formation of tissues. Here, I am interested in the roles of both ACTIVIN/NODAL and βCATENIN signaling pathways in the specification of cell identities during the maturation of the mouse blastocyst
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Smith, Malcolm. "Regulating IVF and pre-implantation tissue-typing for the creation of "saviour siblings" : a harm analysis." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/35798/1/Malcolm_Smith_Thesis.pdf.

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Scientific discoveries, developments in medicine and health issues are the constant focus of media attention and the principles surrounding the creation of so called ‘saviour siblings’ are of no exception. The development in the field of reproductive techniques has provided the ability to genetically analyse embryos created in the laboratory to enable parents to implant selected embryos to create a tissue-matched child who may be able to cure an existing sick child. The research undertaken in this thesis examines the regulatory frameworks overseeing the delivery of assisted reproductive technologies (ART) in Australia and the United Kingdom and considers how those frameworks impact on the accessibility of in vitro fertilisation (IVF) procedures for the creation of ‘saviour siblings’. In some jurisdictions, the accessibility of such techniques is limited by statutory requirements. The limitations and restrictions imposed by the state in relation to the technology are analysed in order to establish whether such restrictions are justified. The analysis is conducted on the basis of a harm framework. The framework seeks to establish whether those affected by the use of the technology (including the child who will be created) are harmed. In order to undertake such evaluation, the concept of harm is considered under the scope of John Stuart Mill’s liberal theory and the Harm Principle is used as a normative tool to judge whether the level of harm that may result, justifies state intervention or restriction with the reproductive decision-making of parents in this context. The harm analysis conducted in this thesis seeks to determine an appropriate regulatory response in relation to the use of pre-implantation tissue-typing for the creation of ‘saviour siblings’. The proposals outlined in the last part of this thesis seek to address the concern that harm may result from the practice of pre-implantation tissue-typing. The current regulatory frameworks in place are also analysed on the basis of the harm framework established in this thesis. The material referred to in this thesis reflects the law and policy in place in Australia and the UK at the time the thesis was submitted for examination (December 2009).
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Books on the topic "Pre-implantation embryo"

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Regulating pre-implantation genetic diagnosis: A comparative and theoretical analysis. Abingdon, Oxon [UK]: Routledge, 2012.

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Marie, O'Leary, and Arnett John 1959-, eds. Pregnancy protein research. Hauppauge, NY: Nova Science Publishers, 2009.

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Elliston, Sarah, and Sheila A. M. McLean. Regulating Pre-Implantation Genetic Diagnosis: A Comparative and Theoretical Analysis. Taylor & Francis Group, 2014.

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Elliston, Sarah, and Sheila A. M. McLean. Regulating Pre-Implantation Genetic Diagnosis: A Comparative and Theoretical Analysis. Taylor & Francis Group, 2012.

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Elliston, Sarah, and Sheila A. M. McLean. Regulating Pre-Implantation Genetic Diagnosis: A Comparative and Theoretical Analysis. Taylor & Francis Group, 2012.

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Book chapters on the topic "Pre-implantation embryo"

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Boatman, Dorothy E. "In Vitro Growth of Non-Human Primate Pre- and Peri- Implantation Embryos." In The Mammalian Preimplantation Embryo, 273–308. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5332-4_13.

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Lau, Pin Lean. "The Legal and Ethical Debates in Embryo Selection." In Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions, 73–121. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22308-3_3.

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Pollard, Jeffrey W. "Colony Stimulating Factor-1 in the Female Reproductive Tract During the Pre- and Peri-Implantation Periods." In Endocrinology of Embryo-Endometrium Interactions, 253–68. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-1881-5_21.

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Schatten, Heide, and Qing-Yuan Sun. "Posttranslationally Modified Tubulins and Other Cytoskeletal Proteins: Their Role in Gametogenesis, Oocyte Maturation, Fertilization and Pre-implantation Embryo Development." In Advances in Experimental Medicine and Biology, 57–87. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0817-2_4.

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Meyer, John R. "The Ontological Status of Pre-implantation Embryos." In Philosophy and Medicine, 17–34. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55766-3_3.

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Heindryckx, Björn, Josiane Elst, and Marc Dhont. "Culture Medium Preferences of Pre-Implantation Cloned Mouse Embryos." In Methods in Molecular Biology, 59–77. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59745-154-3_4.

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Muggleton-Harris, A. L. "Proliferation of Cells Derived from the Biopsy of Pre-Implantation Embryos." In Advances in Assisted Reproductive Technologies, 887–98. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4613-0645-0_91.

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Bazer, Fuller W., Greg A. Johnson, and Thomas E. Spencer. "Growth and Development: Pre‐Implantation Embryo." In Encyclopedia of Animal Science, Second Edition, 601–3. CRC Press, 2011. http://dx.doi.org/10.1081/e-eas2-120041186.

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Ornoy, Asher, and Noa Bischitz. "Diabetic embryopathy in the pre-implantation embryo." In Textbook of Diabetes and Pregnancy, 165–72. Informa Healthcare, 2008. http://dx.doi.org/10.3109/9781439802007.022.

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"PGD and the making of the ‘genetic embryo’ as a political tool." In Regulating Pre-Implantation Genetic Diagnosis, 53–84. Routledge, 2012. http://dx.doi.org/10.4324/9780203096376-8.

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Conference papers on the topic "Pre-implantation embryo"

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Wang, Zenan, and Wei Tech Ang. "Automatic zona pellucida dissection position selection for embryo biopsy in pre-implantation genetic diagnosis." In 2014 IEEE International Conference on Robotics and Biomimetics (ROBIO). IEEE, 2014. http://dx.doi.org/10.1109/robio.2014.7090376.

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Wang, Ze Nan, Wei Tech Ang, Su Zhao, and Tat Joo Teo. "Application of lateral oscillating piezo-driven micropipette in embryo biopsy for pre-implantation genetic diagnosis." In 2014 13th International Conference on Control Automation Robotics & Vision (ICARCV). IEEE, 2014. http://dx.doi.org/10.1109/icarcv.2014.7064489.

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Le Gac, Severine. "Microfluidic technology: New opportunities to develop physiologically relevant in vitro models integrated microfluidic platform for the in vitro pre-implantation culture of individual mammalian embryos and their in situ characterization." In ESSDERC 2017 - 47th IEEE European Solid-State Device Research Conference (ESSDERC). IEEE, 2017. http://dx.doi.org/10.1109/essderc.2017.8066641.

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You might also be interested in the extended bibliographies on the topic 'Pre-implantation embryo' for particular source types:
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