Relevant bibliographies by topics / Pre-clinical imaging

Academic literature on the topic 'Pre-clinical imaging'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Pre-clinical imaging"

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Drexler, W. "SP-0516: Optical imaging in pre-clinical research." Radiotherapy and Oncology 106 (March 2013): S200. http://dx.doi.org/10.1016/s0167-8140(15)32822-x.

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Hazle, J. "WE-EF-204-01: Pre-Clinical Imaging for Co-Clinical Trials." Medical Physics 42, no. 6Part39 (June 2015): 3680. http://dx.doi.org/10.1118/1.4926004.

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Meikle, Steven, Stefan Eberl, and Hidehiro Iida. "Instrumentation and Methodology for Quantitative Pre-Clinical Imaging Studies." Current Pharmaceutical Design 7, no. 18 (December 1, 2001): 1945–66. http://dx.doi.org/10.2174/1381612013396961.

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Kondrashova, T., D. De Wan, M. U. Briones, and P. Kondrashov. "Integration of ultrasound imaging into pre-clinical dental education." European Journal of Dental Education 21, no. 4 (April 4, 2016): 228–34. http://dx.doi.org/10.1111/eje.12205.

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Madonna, R., C. Cevik, and N. Cocco. "Multimodality imaging for pre-clinical assessment of Fabry's cardiomyopathy." European Heart Journal - Cardiovascular Imaging 15, no. 10 (June 5, 2014): 1094–100. http://dx.doi.org/10.1093/ehjci/jeu080.

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Zöllner, Frank G., Raffi Kalayciyan, Jorge Chacón-Caldera, Fabian Zimmer, and Lothar R. Schad. "Pre-clinical functional Magnetic Resonance Imaging part I: The kidney." Zeitschrift für Medizinische Physik 24, no. 4 (December 2014): 286–306. http://dx.doi.org/10.1016/j.zemedi.2014.05.002.

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Meßner, Nadja M., Frank G. Zöllner, Raffi Kalayciyan, and Lothar R. Schad. "Pre-clinical functional Magnetic Resonance Imaging part II: The heart." Zeitschrift für Medizinische Physik 24, no. 4 (December 2014): 307–22. http://dx.doi.org/10.1016/j.zemedi.2014.06.008.

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Finegan, K., M. Babur, D. Forster, J. O’Connor, C. Tournier, and K. Williams. "A novel pre-clinical model for imaging cancer-associated inflammation." European Journal of Cancer 61 (July 2016): S107. http://dx.doi.org/10.1016/s0959-8049(16)61377-1.

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O'Neill, Karen, Scott K. Lyons, William M. Gallagher, Kathleen M. Curran, and Annette T. Byrne. "Bioluminescent imaging: a critical tool in pre-clinical oncology research." Journal of Pathology 220, no. 3 (October 27, 2009): 317–27. http://dx.doi.org/10.1002/path.2656.

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ÁLVAREZ, F. J., J. BISBE, V. BISBE, and A. DÁVALOS. "MAGNETIC RESONANCE IMAGING FINDINGS IN PRE-CLINICAL CREUTZFELDT-JAKOB DISEASE." International Journal of Neuroscience 115, no. 8 (January 2005): 1219–25. http://dx.doi.org/10.1080/00207450590914491.

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Dissertations / Theses on the topic "Pre-clinical imaging"

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Bianchi, Andrea. "Magnetic resonance imaging techniques for pre-clinical lung imaging." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0060/document.

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Dans ce travail, les s´séquences Imagerie par Résonance Magnétique (IRM) radiales à temps d’écho ultra-court (UTE) sont analysées pour évaluer leur potentiel dans l’étude non-invasive de différents modèles expérimentaux de maladies pulmonaires chez la souris. Chez le petit animal, les séquences radiales UTE peuvent efficacement limiter l’impact négatif sur la qualité de l’image dû au déphasage rapide des spins causé par les nombreuses interfaces air/tissu. En plus, les séquences radiales UTE sont moins sensibles aux artefacts de mouvement par rapport aux séquences Cartésiennes classiques. En conséquence, chez le petit animal, les séquences radiales UTE peuvent permettre d’obtenir des images du poumon avec une résolution bien inférieure au millimètre avec des rapports signal/bruit importants dans le parenchyme pulmonaire, tout en travaillant en conditions physiologiques (animaux en respiration spontanée). Dans cette thèse, il sera démontré que les séquences d’IRM protonique UTE sont outils efficaces dans l’étude quantitative et non-invasive de différents marqueurs distinctifs de certaines pathologies pulmonaires d’intérêt général. Les protocoles développés serontsimples, rapides et non-invasifs, faciles à implémenter, avec une interférence minimale sur la pathologie pulmonaire étudiée et, en définitive, potentiellement applicables chez l’homme. Il sera ainsi démontré que l’emploi des agents de contraste, administrés via les voies aériennes, permet d’augmenter la sensibilité des protocoles développés. Parallèlement, dans cette thèse des protocoles suffisamment flexibles seront implémentés afin de permettre l’étude d’un agent de contraste paramagnétique générique pour des applications aux poumons
In this work, ultra-short echo time (UTE) Magnetic Resonance Imaging (MRI) sequences are investigated as flexible tools for the noninvasive study of experimental models of lung diseases in mice. In small animals radial UTE sequences can indeed efficiently limit the negative impact on lung image quality due to the fast spin dephasing caused by the multiple air/tissue interfaces. In addition, radial UTE sequences are less sensitive to motion artifacts compared to standard Cartesian acquisitions. As a result, radial UTE acquisitions can provide lung images in small animals at sub-millimetric resolution with significant signal to noise ratio in the lung parenchyma, while working with physiological conditions (freely-breathing animals). In this thesis, UTE proton MRI sequences were shown to be efficient instruments to quantitatively investigate a number of hallmarks in longitudinal models of relevant lung diseases with minimal interference with the lung pathophysiology, employing easilyimplementable fast protocols. The synergic use of positive contrast agents, along with anadvantageous administration modality, was shown to be a valuable help in the increase of sensitivity of UTE MRI. At the same time, UTE MRI was shown to be an extremely useful and efficacious sequence for studying positive contrast agents in lungs
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Almeida, Gilberto Serrano de. "Pre-clinical imaging evaluation of the PARP inhibitor rucaparib." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2033.

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Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA-binding enzyme involved in DNA repair by the base-excision pathway. The inhibition of PARP1 is being investigated as a cancer treatment. Rucaparib (CO338) is a potent PARP 31 inhibitor currently in Phase II clinical development. In this thesis P in vivo MR Spectroscopy (MRS) and Dynamic Contrast Enhanced (DCE) MRI were used to study acute effects of rucaparib on energy metabolism and tumour vasculature. 1 31 18 18 Ex vivo H and P-MRS, and in vivo [ F]FLT and [ F]FDG-PET, were used to study effects of treatment with rucaparib on tumour metabolism and proliferation. A2780 and SW620 tumours implanted in mice were scanned in a horizontal Varian 7T MR system. Two i.v. injections of the MRI contrast agent gadoteridol were given 90 minutes apart with dynamic phosphorus MRS acquired following the injection of rucaparib, temozolomide or both drugs in combination. The 18 18 same tumours were evaluated by [ F]FLT- and [ F]FDG-PET after 5 daily treatments with rucaparib, temozolomide or the combination, and the livers of PARP1 knock out (KO) and wild type (WT) mice treated in a similar manner 1 31 were analysed by ex vivo H and P-MRS. Tumour uptake of gadoteridol changed significantly after treatment with hydralazine and higher doses of rucaparib in SW620 tumours, and following 31 hydralazine and 1mg/Kg of rucaparib in A2780 tumours. P-MRS studies revealed an increase in the inorganic phosphate (Pi) to β-NTP ratio, consistent with impairment of tumour energy metabolism following hydralazine treatment. 18 [ F]FLT-PET demonstrated a significant reduction in the SUV values in the 18 rucaparib/temozolomide combination group in SW620 tumours, and [ F]FDG- PET revealed a non-significant reduction in tumour metabolism in A2780 1 tumours. H ex vivo MRS demonstrated an increase in the liver NAD concentrations after treatment with rucaparib, but a decrease following the treatment with temozolomide, regardless of the PARP1 status. Together, these pre-clinical imaging studies have shown that MR can be used 18 to investigate the acute anti-vascular effects of rucaparib, that [ F]FLT-PET predicted subsequent changes in tumour volume following combined rucaparib 1 and temozolomide treatment, and that ex vivo H-MRS can be used in mechanistic studies of PARP inhibition. Both MRI/MRS and PET are potential pharmacodynamic and surrogate response imaging biomarkers for PARP inhibitors.
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Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.

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In this thesis, we describe several imaging techniques specifically designed and developed for the assessment of pulmonary structure, function and pathology. We then describe the application of this technology within appropriate biological systems, including the identification, tracking and assessment of lung tumors in a mouse model of lung cancer. The design and development of a Large Image Microscope Array (LIMA), an integrated whole organ serial sectioning and imaging system, is described with emphasis on whole lung tissue. This system provides a means for acquiring 3D pathology of fixed whole lung specimens with no infiltrative embedment medium using a purpose-built vibratome and imaging system. This system enables spatial correspondence between histology and non-invasive imaging modalities such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET), providing precise correlation of the underlying 'ground truth' pathology back to the in vivo imaging data. The LIMA system is evaluated using fixed lung specimens from sheep and mice, resulting in large, high-quality pathology datasets that are accurately registered to their respective CT and H&E histology. The implementation of an in vivo micro-CT imaging system in the context of pulmonary imaging is described. Several techniques are initially developed to reduce artifacts commonly associated with commercial micro-CT systems, including geometric gantry calibration, ring artifact reduction and beam hardening correction. A computer controlled Intermittent Iso-pressure Breath Hold (IIBH) ventilation system is then developed for reduction of respiratory motion artifacts in live, breathing mice. A study validating the repeatability of extracting valuable pulmonary metrics using this technique against standard respiratory gating techniques is then presented. The development of an ex vivo laser scanning confocal microscopy (LSCM) and an in vivo catheter based confocal microscopy (CBCM) pulmonary imaging technique is described. Direct high-resolution imaging of sub-pleural alveoli is presented and an alveolar mechanic study is undertaken. Through direct quantitative assessment of alveoli during inflation and deflation, recruitment and de-recruitment of alveoli is quantitatively measured. Based on the empirical data obtained in this study, a new theory on alveolar mechanics is proposed. Finally, a longitudinal mouse lung cancer study utilizing the imaging techniques described and developed throughout this thesis is presented. Lung tumors are identified, tracked and analyzed over a 6-month period using a combination of micro-CT, micro-PET, micro-MRI, LSCM, CBCM, LIMA and H&E histology imaging. The growth rate of individual tumors is measured using the micro-CT data and traced back to the histology using the LIMA system. A significant difference in tumor growth rates within mice is observed, including slow growing, regressive, disappearing and aggressive tumors, while no difference between the phenotype of tumors was found from the H&E histology. Micro-PET and micro-MRI imaging was conducted at the 6-month time point and revealed the limitation of these systems for detection of small lesions ( < 2mm) in this mouse model of lung cancer. The CBCM imaging provided the first high-resolution live pathology of this mouse model of lung cancer and revealed distinct differences between normal, suspicious and tumor regions. In addition, a difference was found between control A/J mice parenchyma and Urethane A/J mice ‘normal’ parenchyma, suggesting a 'field effect' as a result of the Urethane administration and/or tumor burden. In conclusion, a comprehensive murine lung cancer imaging study was undertaken, and new information regarding the progression of tumors over time has been revealed.
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Assadian, Sarah. "Rodent FDG-PET imaging for the pre-clinical assessment of novel glioma therapies." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101836.

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The rapid discovery of novel therapeutic agents, targeting the specific mechanism of cancer progression, invasion and angiogenesis, necessitates the development and validation of efficient techniques to assess the therapeutic efficacy of these drugs in vivo. Recently the development of dedicated PET scanners for the imaging of small animals, such as the microPET system (CTI Concorde R4), has allowed for the high-resolution functional and molecular imaging of murine and rodent models of disease. This study, investigates the ability of microPET imaging, using the 18F labelled 2-fluoro-2-deoxyglucose (FDG) PET tracer, to detect the therapeutic efficacy of novel targeted therapies in a rat model of glioma. This technique potentially allows for the rapid and high-throughput assessment of tumour response and evaluation of efficacy of such therapeutic agents in vivo at the pre-clinical stage and will, consequently, facilitate the translation of these novel drugs from the discovery to the clinical phases.
La découverte accélérée de nouvelles molécules thérapeutiques qui ciblent lesmécanismes de progression du cancer tels que l'invasion et l'angiogenèse, nécessite lamise au point et la validation de techniques efficaces qui permettent d'évaluer l'efficacitéthérapeutique de ces agents in vivo. Le développement récent des scanners detomographie à émission de positron (TEP) dédiés à l'imagerie de petits animaux(microPET, CT! Concorde R4), permet aujourd'hui d'obtenir une image fonctionnelle etmoléculaire de haute résolution des modèles rongeurs. Cette étude s'intéresse au potentieldu 18F-2-fluoro-2-deoxyglucose (FDG) en utilisant l'imagerie microPET dansl'évaluation de l'efficacité de nouveaux agents thérapeutiques dans un modèle de gliomechez le. rat. Cette technique pourrait éventuellement mener à une évaluation rapide et àgrande échelle de la réponse tumorale, ainsi que la mesure de l'efficacité d'agentsthérapeutiques in vivo au stade d'étude préclinique. Globalement, cette étude a pour butde faciliter la transition entre la découverte de nouvelles molécules thérapeutiques et leursapplications cliniques.
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Ambrosini, Valentina <1975&gt. "Pre-clinical imaging: small animal pet and CT applications in pneumology, oncology and cardiology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1087/.

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Chen, Liu Qi. "Development and Application of AcidoCEST MRI for Evaluating Tumor Acidosis in Pre-Clinical Cancer Models." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/323450.

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Tumor acidosis is an important biomarker in cancer. We have developed a noninvasive imaging method, termed acidosis Chemical Exchange Saturation Transfer (acidoCEST) MRI to measure extracellular pH (pHe) in the tumor microenvironment. Chapter 1 introduces the importance of measuring tumor acidosis and presents various imaging modalities and their shortcoming to measure pHe. Chapter 2 describes the optimization of acidoCEST MRI for in vivo pHe measurement. The acidoCEST MRI protocol consists of a CEST-FISP acquisition and Lorentzian line shape fittings. We determined the optimal saturation time, saturation power and bandwidth, 5 sec, 2.8 µT and 90 Hz respectively. We also tried various routes of administration to increase contrast agent uptake in the tumor. We decided upon 200 µL bolus followed by 150 µL/hr infusion. The optimized acidoCEST MRI protocol was tested on a mammary carcinoma mouse model of MDA- MB-231. Our method can detect an increase in pHe in the bladder and tumor of the mice treated with bicarbonate. We used this optimized acidoCEST MRI method to measure pHe in lymphoma tumor model of Raji, Ramos and Granta 519 as described in Chapter 3. Pixel-wise pHe maps showed tumor heterogeneity. The pHe of Raji, Ramos and Granta 519 were determined to be mildly acidic with no significant difference. Chapter 4 describes the evolution of pixel-wise analysis in more detail. Besides the pHe map and spatial heterogeneity, we were able to determine the % contrast agent uptake. We monitored these biomarkers in two different mammary carcinoma mouse models, MDA- MB-231 and MCF-7 longitudinally and made comparisons between the different tumor models: MCF-7 were more acidic, more heterogeneous and faster growing than MDA- MB-231.
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Jones, Bernard Lee. "Development of dosimetry and imaging techniques for pre-clinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43727.

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Cancer is one of the leading causes of death worldwide, and affects roughly 1.5 million new people in the United States every year. One of the leading tools in the detection and treatment of cancer is radiation. Tumors can be detected and identified using CT or PET scans, and can then be treated with external beam radiotherapy or brachytherapy. By taking advantage of the physical properties of gold and the biological properties of nanoparticles, gold nanoparticles (GNPs) can be used to improve both cancer radiotherapy and imaging. By infusing a tumor with GNPs, either using passive extravasation of nanoparticles by the tumor vasculature or active targeting of an antibody-conjugated nanoparticle to a specific tumor marker, the higher photon cross-section of gold will cause more radiation dose to be deposited in the tumor during photon-based radiotherapy. In principle, this would allow escalation of dose to the tumor while not increasing the dose to normal healthy tissue. Additionally, if a tumor infused with GNPs was irradiated by an external kilo-voltage source, the fluorescence emitted by the gold atoms would allow one to localize and quantify the GNP concentration. This work has two main aims: to quantify the GNP-mediated dose enhancement during GNRT on a nanometer scale, and to develop a refined imaging modality capable of quantifying GNP location and concentration within a small-animal-sized object. In order to quantify the GNP-mediated dose enhancement on a nanometer scale, a computational model was developed. This model combines both large-scale and small-scale calculations in order to accurately determine the heterogeneous dose distribution of GNPs. The secondary electron spectra were calculated using condensed history Monte Carlo, which is able to accurately take into account changes in beam quality throughout the tumor and calculate the average energy spectrum of the secondary charged particles created. Then, the dose distributions of these electron spectra were calculated on a nanometer scale using event-by-event Monte Carlo. The second aim is to develop an imaging system capable of reconstructing a tomographic image of GNP location and concentration in a small animal-sized object by capturing gold fluorescence photons emitted during irradiation of the object by an external beam. This would not only allow for localization of GNPs during gold nanoparticle-aided radiation therapy (GNRT), but also facilitate the use of GNPs as imaging agents for drug-delivery or other similar studies. The purpose of this study is to develop a cone-beam implementation of XFCT that meets realistic constrains on image resolution, detection limit, scan time, and dose. A Monte Carlo model of this imaging geometry was developed and used to test the methods of data acquisition and image reconstruction. The results of this study were then used to drive the production of a functioning benchtop, polychromatic cone-beam XFCT system.
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Landuyt, Willy. "Intra-tumoural blood vessels and hypoxia: targets for treatment and imaging to improve anti-cancer therapies pre-clinical investigations /." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2002. http://arno.unimaas.nl/show.cgi?fid=7247.

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Onthank, David C. "Prediction of "First Dose in Human" for radiopharmaceuticals/imaging agents based on allometric scaling of pharmacokinetics in pre-clinical animal models." Link to electronic dissertation, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-011006-132234/.

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Adcock, Jane Elizabeth St Vincent's Clinical School UNSW. "The reliability and clinical validity of functional magnetic resonance imaging in the assessment of language in pre-surgical patients with temporal lobe epilepsy." Awarded by:University of New South Wales. St Vincent's Clinical School, 2005. http://handle.unsw.edu.au/1959.4/22484.

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Defining language lateralisation is important to minimise morbidity in patients treated surgically for temporal lobe epilepsy (TLE). Functional magnetic resonance imaging (fMRI) offers a promising, non-invasive, alternative strategy to the Wada test. Here, fMRI has been used to study healthy controls and patients with TLE in order (i) to define language-related activation patterns and their reproducibility; (ii) to compare lateralisation determined by fMRI with that from the Wada test; and (iii) to explore the usefulness of multiple fMRI language paradigms. 18 healthy controls (12 right-handed and 6 left-handed) and 24 pre-operative TLE patients (19 right-handed: 12 left-TLE, 7 right-TLE; 5 left-handed: 2 right-TLE, 3 left-TLE) were studied using fMRI. Four fMRI language paradigms used: phonetic and semantic fluency, and the naming of living and non-living things. The data for all 4 tasks were acquired during a single scanning session on two occasions. All patients also underwent Wada testing. In patients and controls, phonetic and semantic fluency tasks were robustly activating and strongly lateralising. Quantified language-related lateralisation from fMRI verbal fluency data was highly reproducible and concordant with the lateralisation of the Wada test. Both fluency tasks identified patients with atypical language lateralisation, including 4/12 right-handed patients with left-TLE and 4/5 left-handed TLE patients, regardless of the side of epileptic focus. In comparison, the two confrontational naming tasks were not strongly lateralising and did not reliably agree with Wada lateralisation in either 12 right-handed controls or 19 right-handed patients with TLE. However, there was a difference in the pattern of fMRI activation in right-handed pat ients with left-TLE. Left-TLE patients had a more right lateralised network of activation when naming living things relative to non-living things, suggesting that some patients may be at risk of a category specific naming decline for non-living things after left anterior temporal lobectomy. These results demonstrate that non-invasive fMRI measures of languagerelated lateralisation may provide a practical and reliable alternative to invasive testing for pre-surgical language lateralisation in patients with TLE. The high proportion of TLE patients showing atypical language lateralisation suggests considerable plasticity of language representation in the brains of patients with intractable TLE.
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Books on the topic "Pre-clinical imaging"

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Najarian, Kayvan. Biomedical Signal and Image Processing. Boca Raton: Taylor & Francis, 2012.

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Nixdorff, Uwe, Stephan Achenbach, Frank Bengel, Pompillio Faggiano, Sara Fernández, Christian Heiss, Thomas Mengden, et al. Imaging in cardiovascular prevention. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656653.003.0006.

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Imaging tools in preventive cardiology can be divided into imaging modalities to assess pre-clinical and clinical atherosclerosis and functional assessments of vascular function or vascular inflammation. To calculate the likelihood of pre-clinical atherosclerosis intima-media thickness as well as coronary calcium scoring are most frequently used. However, beyond these two there are other parameters derived by ultrasound and multi-detector computed tomography as well as magnetic resonance imaging and nuclear/molecular imaging which are discussed in the chapter. Functional tests include flow-mediated dilatation, pulse wave analysis, and the ankle-brachial index. In clinical research other invasive measurements such as intravascular ultrasound/virtual histology/elastography, optical coherence tomography as well as thermography are being used. However, their value in clinical prevention still needs to be established.
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Cleverley, Joanne. The imaging of fungal disease. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0041.

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The imaging of fungal infection is diverse and often non-specific with multiple abnormalities commonly identified, frequently with more than one organ involved. By correlating the clinical information, which should include patient immune status, pre-existing chronic disease, and potential exposure to endemic fungi, and using this information with an awareness of the radiographic findings of fungal infection, a potential diagnosis can be ascertained. In this chapter, the imaging of fungal infection is discussed, concentrating on the various imaging modalities available, their role, and the major organs involved, highlighting any distinguishing radiographic findings, which may help in the search for a definitive diagnosis.
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Loving, Vilert A. Pre-Operative Localization. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0059.

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Non-palpable, surgical breast lesions require image guidance to direct the site of excision. With the widespread adoption of screening mammography and increased identification of non-palpable breast cancers, image guidance is critical to support the surgeon in successful breast-conserving surgery. Pre-operative localization procedures are typically performed under mammography guidance or ultrasound guidance, and less commonly under magnetic resonance imaging (MRI) guidance. This chapter, appearing in the section on interventions and surgical changes, reviews protocols and pitfalls, pre-/peri-/post-procedure clinical management, and imaging follow-up of pre-operative localization procedures. Topics discussed include mammography-guided, ultrasound-guided, and MRI-guided localization procedures. This chapter also introduces the radioactive seed and radiofrequency identification localization procedures and discusses post-operative specimen radiographs.
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Splinter, Robert, and Kayvan Najarian. Biomedical Signal and Image Processing. Taylor & Francis Group, 2016.

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Splinter, Robert, and Kayvan Najarian. Biomedical Signal and Image Processing. Taylor & Francis Group, 2016.

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Kayvan, Najarian, and Splinter Robert, eds. Biomedical signal and image processing. Boca Raton, FL: CRC/Taylor & Francis, 2005.

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Splinter, Robert, and Kayvan Najarian. Biomedical Signal and Image Processing. Taylor & Francis Group, 2016.

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Wang, Sigen, Otto Zhou, and Sha Chang. Carbon-nanotube field emission electron and X-ray technology for medical research and clinical applications. Edited by A. V. Narlikar and Y. Y. Fu. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533060.013.19.

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This article describes carbon-nanotube based X-ray technologies for medical research and clinical applications, including an X-ray source, microfocus X-ray tube, microcomputed tomography scanner, stationary digital breast tomosynthesis, microradiotherapy system, and single-cell irradiation system. It first examines electron field emission from carbon nanotubes before discussing carbon-nanotube field emission electron and X-ray technologies in greater detail. It highlights the enormous promise of these systems in commercial and research application for the future in diagnostic medical imaging; in-vivo imaging of small-animal modelsfor pre-clinical cancer studies; security screening; industrial inspection; cancer radiotherapy of small-animal models for pre-clinical cancer studies; and basic cancer research using single-cell irradiation.
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McCormick, Patrick Neil. Pre-clinical evaluation of [carbon-11]-(+)-PHNO as an agonist positron emission tomography (PET) radiotracer for imaging of the high-affinity state of the dopamine D2 receptor. 2006.

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Book chapters on the topic "Pre-clinical imaging"

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Rasey, Janet S., Gary V. Martin, and Kenneth A. Krohn. "Quantifying Hypoxia with Radiolabeled Fluoromisonidazole: Pre-Clinical and Clinical Studies." In Imaging of Hypoxia, 85–117. Dordrecht: Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-017-1828-8_6.

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Hill, Melissa L., Kela Liu, James G. Mainprize, Ronald B. Levitin, Rushin Shojaii, and Martin J. Yaffe. "Pre-clinical Evaluation of Tumour Angiogenesis with Contrast-Enhanced Breast Tomosynthesis." In Breast Imaging, 1–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31271-7_1.

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André, M. P., C. H. Barker, N. Sekhon, J. Wiskin, D. Borup, and K. Callahan. "Pre-Clinical Experience with Full-Wave Inverse-Scattering for Breast Imaging." In Acoustical Imaging, 73–80. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-8823-0_10.

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Lyons, Scott K., and Kevin M. Brindle. "Molecular Imaging of Cancer and the Implications for Pre-invasive Disease." In Pre-Invasive Disease: Pathogenesis and Clinical Management, 167–207. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6694-0_10.

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Bringout, Gael, Hanne Wojtczyk, Mandy Grüttner, Matthias Graeser, Wiebke Tenner, Julian Hägele, Florian M. Vogt, Jörg Barkhausen, and Thorsten M. Buzug. "Safety Aspects for a Pre-clinical Magnetic Particle Imaging Scanner." In Springer Proceedings in Physics, 355–59. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-24133-8_57.

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Nadjmi, Maschallah. "MRI of Syringomyelia: Comparison of Pre-Postoperative Results with Clinical Symptoms." In Imaging of Brain Metabolism Spine and Cord Interventional Neuroradiology Free Communications, 187–90. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74337-5_48.

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Lao, Yi, Sinchai Tsao, and Natasha Lepore. "Computer Aided Diagnosis in Pre-Clinical Dementia: From Single-Modal Metrics to Multi-Modal Fused Methodologies." In Big Data in Multimodal Medical Imaging, 47–70. Boca Raton : CRC Press, [2020]: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/b22410-3.

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Frostig, Ron D. "Intrinsic Signal Optical Imaging (ISOI): State-of-the-Art with Emphasis on Pre-clinical and Clinical Studies." In Brain Informatics and Health, 111–27. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6883-1_5.

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Gomes, C. M., M. M. Welling, I. Que, N. Henriquez, G. van der Pluijm, A. J. Abrunhosa, M. F. Botelho, P. C. W. Hogendoorn, E. K. J. Pauwels, and A. M. Cleton-Jansen. "Imaging Multidrug Resistance in Osteosarcoma: A Pre-clinical Approach Using an Orthotopic Animal Model." In IFMBE Proceedings, 784–87. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03879-2_219.

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Denisko, Danielle, Samuel Oduneye, Philippa Krahn, Sudip Ghate, Ilan Lashevsky, Graham Wright, and Mihaela Pop. "Analysis of Activation-Recovery Intervals from Intra-cardiac Electrograms in a Pre-clinical Chronic Model of Myocardial Infarction." In Functional Imaging and Modelling of the Heart, 280–88. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-59448-4_27.

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Conference papers on the topic "Pre-clinical imaging"

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WIEBE, LEONARD I. "MEDICAL IMAGING APPLICATIONS IN PRE-CLINICAL AND CLINICAL MEDICINE." In Proceedings of the 3rd International Conference on Isotopes. WORLD SCIENTIFIC, 2000. http://dx.doi.org/10.1142/9789812793867_0046.

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Cruje, Charmainne, Justin J. Tse, David W. Holdsworth, Elizabeth R. Gillies, and Maria Drangova. "Blood-pool contrast agent for pre-clinical computed tomography." In SPIE Medical Imaging, edited by Thomas G. Flohr, Joseph Y. Lo, and Taly Gilat Schmidt. SPIE, 2017. http://dx.doi.org/10.1117/12.2255581.

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Weis, Jared A., Thomas E. Yankeelov, Samantha A. Munoz, Rahul A. Sastry, Stephanie L. Barnes, Lori R. Arlinghaus, Xia Li, and Michael I. Miga. "A consistent pre-clinical/clinical elastography approach for assessing tumor mechanical properties in therapeutic systems." In SPIE Medical Imaging, edited by John B. Weaver and Robert C. Molthen. SPIE, 2013. http://dx.doi.org/10.1117/12.2007425.

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Cruje, Charmainne, David W. Holdsworth, Elizabeth R. Gillies, and Maria Drangova. "High-concentration gadolinium nanoparticles for pre-clinical vascular imaging." In Physics of Medical Imaging, edited by Guang-Hong Chen, Joseph Y. Lo, and Taly Gilat Schmidt. SPIE, 2018. http://dx.doi.org/10.1117/12.2293016.

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Parnham, K. B., S. Chowdhury, J. Li, D. J. Wagenaar, and B. E. Patt. "Second-Generation, Tri-Modality Pre-Clinical Imaging System." In 2006 IEEE Nuclear Science Symposium Conference Record. IEEE, 2006. http://dx.doi.org/10.1109/nssmic.2006.354244.

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Wu, Yanjun, Jeremy W. Wellen, and Susanta K. Sarkar. "Multi-modality molecular imaging: pre-clinical laboratory configuration." In Biomedical Optics 2006, edited by Fred S. Azar and Dimitris N. Metaxas. SPIE, 2006. http://dx.doi.org/10.1117/12.660244.

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Tibbelin, Sandra, Peter Nillius, Björn Cederström, and Mats Danielsson. "HyperSPECT: a new system for pre-clinical imaging in vivo." In SPIE Medical Imaging, edited by Ehsan Samei and Jiang Hsieh. SPIE, 2009. http://dx.doi.org/10.1117/12.812964.

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Vogel, P., S. Herz, M. A. Ruckert, C. Brede, A. Brandl, T. Kampf, S. Veldhoen, et al. "Traveling wave MPI goes pre-clinical application." In 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI). IEEE, 2015. http://dx.doi.org/10.1109/iwmpi.2015.7106997.

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Guggenheim, James A., Hector R. A. Basevi, Iain B. Styles, Jon Frampton, and Hamid Dehghani. "Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging." In European Conferences on Biomedical Optics, edited by Paola Taroni and Hamid Dehghani. SPIE, 2013. http://dx.doi.org/10.1117/12.2033317.

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Du, Louise Y., Ting-Yim Lee, and David W. Holdsworth. "Image quality assessment of a pre-clinical flat-panel volumetric micro-CT scanner." In Medical Imaging, edited by Michael J. Flynn and Jiang Hsieh. SPIE, 2006. http://dx.doi.org/10.1117/12.650970.

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Reports on the topic "Pre-clinical imaging"

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Gilland, David R. Pre-clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices. Fort Belvoir, VA: Defense Technical Information Center, October 2009. http://dx.doi.org/10.21236/ada564056.

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Gilland, David R. Pre-clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices. Fort Belvoir, VA: Defense Technical Information Center, October 2010. http://dx.doi.org/10.21236/ada585696.

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Gilland, David R. Pre-Clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada585792.

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Gilland, David R. Pre-Clinical and Clinical Evaluation of High Resolution, Mobile Gamma Camera and Positron Imaging Devices. Fort Belvoir, VA: Defense Technical Information Center, November 2007. http://dx.doi.org/10.21236/ada585791.

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