Academic literature on the topic 'Pragmatic organisation dynamic display'

Individuals with autism spectrum disorders (ASD) are severely challenged by their difficulties with language and communication. Some research suggests that augmented language input, whereby a speaking communication partner adopts and uses an augmentative or alternative communication (AAC) system for both expressive and receptive language, can be effective with these individuals. The Pragmatic Organization Dynamic Display (PODD) system is both a method and tool for developing and utilizing augmented language input. As a promising practice, PODD provides strategies to support the design, production, and implementation of communication systems that enable genuine communication for a variety of functions in all daily environments. PODD includes strategies to minimize some of the common difficulties associated with the use of multi-level communication books. Specifically, PODD: (a) supports the individual who relies on AAC and his/her communication partners to move efficiently between pages to locate required vocabulary, (b) reduces the time required to access vocabulary to produce multi-symbol messages, (c) provides a strategy for quick access to predictable messages, and (d) enables access to a broad range of vocabulary for spontaneous, unpredicted messages. This article explores the use of the PODD system for individuals with ASD, with emphasis on features that address the unique communication challenges faced by these individuals.

This essay hypothesizes that the tension between religious ideology and pragmatism has persisted throughout Iranian history. The Iranian Revolution simply put it on graphic display in the contemporary period. The essay also suggests that the dynamic processes of cultural maturation seem to be shifting the balance of influence increasingly away from religious ideology toward pragmatic calculation of the national interest in the making and implementation of foreign policy decisions. The obvious implications of all this for US-Iran relations are mentioned.

Transmission of malaria-causing parasites to mosquitoes relies on the production of gametocyte stages and their development into gametes. These stages display various microtubule cytoskeletons and the architecture of the corresponding microtubule organisation centres (MTOC) remains elusive. Combining ultrastructure expansion microscopy (U-ExM) with bulk proteome labelling, we first reconstructed in 3D the subpellicular microtubule network which confers cell rigidity to Plasmodium falciparum gametocytes. Upon activation, as the microgametocyte undergoes three rounds of endomitosis, it also assembles axonemes to form eight flagellated microgametes. U-ExM combined with Pan-ExM further revealed the molecular architecture of the bipartite MTOC coordinating mitosis with axoneme formation. This MTOC spans the nuclear membrane linking cytoplasmic basal bodies to intranuclear bodies by proteinaceous filaments. In P. berghei, the eight basal bodies are concomitantly de novo assembled in a SAS6- and SAS4-dependent manner from a deuterosome-like structure, where centrin, γ-tubulin, SAS4 and SAS6 form distinct subdomains. Basal bodies display a fusion of the proximal and central cores where centrin and SAS6 are surrounded by a SAS4-toroid in the lumen of the microtubule wall. Sequential nucleation of axonemes and mitotic spindles is associated with a dynamic movement of γ-tubulin from the basal bodies to the intranuclear bodies. This dynamic architecture relies on two non-canonical regulators, the calcium-dependent protein kinase 4 and the serine/arginine-protein kinase 1. Altogether, these results provide insights into the molecular organisation of a bipartite MTOC that may reflect a functional transition of a basal body to coordinate axoneme assembly with mitosis.

Ideas of homeostasis derive from the concept of the organism as an open system. These ideas can be traced back to Heraclitus. Hopkins, Bernard, Hill, Cannon, Weiner and von Bertalanffy developed further the mechanistic basis of turnover of biological components, and Schoenheimer and Rittenberg were pioneers of experimental approaches to the problems of measuring pool sizes and dynamic fluxes. From the second half of the twentieth century, a biophysical theory mainly founded on self-organisation and Dynamic Systems Theory allowed us to approach the quantitative and qualitative analysis of the organised complexity that characterises living systems. This combination of theoretical framework and more refined experimental techniques revealed that feedback control of steady states is a mode of operation that, although providing stability, is only one of many modes and may be the exception rather than the rule. The concept of homeodynamics that we introduce here offers a radically new and all-embracing concept that departs from the classical homeostatic idea that emphasises the stability of the internal milieu toward perturbation. Indeed, biological systems are homeody- namic because of their ability to dynamically self-organise at bifurcation points of their behaviour where they lose stability. Consequently, they exhibit diverse behaviour; in addition to monotonic stationary states, living systems display complex behaviour with all its emergent characteristics, i.e., bistable switches, thresholds, waves, gradients, mutual entrainment, and periodic as well as chaotic behaviour, as evidenced in cellular phenomena such as dynamic (supra)molecular organisation and flux coordination. These processes may proceed on different spatial scales, as well as across time scales, from the very rapid processes within and between molecules in membranes to the slow time scales of evolutionary change. It is dynamic organisation under homeodynamic conditions that make possible the organised complexity of life.

This paper analyses the determinants of different organisational techniques dedicated to creativity by stressing the crucial role played by the dynamic innovative capacities of firms in this process. In particular, we show that the impact of creativity methods varies with the type of innovator (product versus process; single versus complex). We use a bivariate probit estimation on a sample of 4,570 manufacturing firms drawn from the 2010 French Community Innovation Surveys (CIS 2010) to study how the innovation profiles of firms impact the propensity to use organisational creativity methods. The estimation results show a strong but differentiated impact of the innovation profiles of firms (products/process, single/complex) on the use of different creativity methods. These empirical results display the accuracy of modern research on the determinants of intra-firm organisation of creativity.

Over the recent decade, the number of architectural competitions organised in Lithuania has been continuously growing. Analysis and inventory of the competitions reveal the essential features of the period, qualitative and dynamic changes in this field, and at the same time may be useful for improvement of the competition organisation system in the nearest future. The paper deals with the legislation changes that influence the competitions as well as introduces quantitative and typological analysis of the competitions of 1999–2009 comparing it with that of other periods. Achievements of the Lithuanian architects at international competitions, participation of foreign architects at creative contests of Lithuania are described. New manifestations of architectural criticism of competitions, the theme of plagiarism, gaps in competition organization, “commercialization”, the tendency of strengthening pragmatic ambitions are described. Santrauka Pastarąjį dešimtmetį Lietuvoje organizuojama vis daugiau architektūrinių konkursų. Jų analizė ir inventorizacija ne tik atskleidžia esminius laikotarpio bruožus, kokybinius ir dinaminius poslinkius šioje srityje, bet kartu gali būti naudinga tobulinant konkursų organizavimo sistemą artimiausioje ateityje. Straipsnyje aptariami konkursams įtaką darantys teisinės bazės pokyčiai, atliekama kiekybinė ir tipologinė 1999–2009 m. konkursų analizė, kuri lyginama su kitais periodais. Aprašomi Lietuvos architektų pasiekimai tarptautiniuose konkursuose, užsienio architektų dalyvavimas Lietuvos kūrybinėse varžytuvėse. Aprašomos naujos konkursų architektūros kritikos apraiškos, plagiato tema, konkursų organizacinės spragos, komercialėjimas, pragmatinių siekių stiprėjimo tendencija.

Over the recent decade, the number of architectural competitions organised in Lithuania has been continuously growing. Analysis and inventory of the competitions reveal the essential features of the period, qualitative and dynamic changes in this field, and at the same time may be useful for improvement of the competition organisation system in the nearest future. The paper deals with the legislation changes that influence the competitions as well as introduces quantitative and typological analysis of the competitions of 1999–2009 comparing it with that of other periods. Achievements of the Lithuanian architects at international competitions, participation of foreign architects at creative contests of Lithuania are described. New manifestations of architectural criticism of competitions, the theme of plagiarism, gaps in competition organization, “commercialization”, the tendency of strengthening pragmatic ambitions are described. Santrauka Pastarąjį dešimtmetį Lietuvoje organizuojama vis daugiau architektūrinių konkursų. Jų analizė ir inventorizacija ne tik atskleidžia esminius laikotarpio bruožus, kokybinius ir dinaminius poslinkius šioje srityje, bet kartu gali būti naudinga tobulinant konkursų organizavimo sistemą artimiausioje ateityje. Straipsnyje aptariami konkursams įtaką darantys teisinės bazės pokyčiai, atliekama kiekybinė ir tipologinė 1999–2009 m. konkursų analizė, kuri lyginama su kitais periodais. Aprašomi Lietuvos architektų pasiekimai tarptautiniuose konkursuose, užsienio architektų dalyvavimas Lietuvos kūrybinėse varžytuvėse. Aprašomos naujos konkursų architektūros kritikos apraiškos, plagiato tema, konkursų organizacinės spragos, komercialėjimas, pragmatinių siekių stiprėjimo tendencija.

Chitin is a highly abundant polymer in nature and a principal component of apical extracellular matrices in insects. In addition, chitin has proved to be an excellent biomaterial with multiple applications. In spite of its importance, the molecular mechanisms of chitin biosynthesis and chitin structural diversity are not fully elucidated yet. To investigate these issues, we use Drosophila as a model. We previously showed that chitin deposition in ectodermal tissues requires the concomitant activities of the chitin synthase enzyme Kkv and the functionally interchangeable proteins Exp and Reb. Exp/Reb are conserved proteins, but their mechanism of activity during chitin deposition has not been elucidated yet. Here, we carry out a cellular and molecular analysis of chitin deposition, and we show that chitin polymerisation and chitin translocation to the extracellular space are uncoupled. We find that Kkv activity in chitin translocation, but not in polymerisation, requires the activity of Exp/Reb, and in particular of its conserved Nα-MH2 domain. The activity of Kkv in chitin polymerisation and translocation correlate with Kkv subcellular localisation, and in absence of Kkv-mediated extracellular chitin deposition, chitin accumulates intracellularly as membrane-less punctae. Unexpectedly, we find that although Kkv and Exp/Reb display largely complementary patterns at the apical domain, Exp/Reb activity nonetheless regulates the topological distribution of Kkv at the apical membrane. We propose a model in which Exp/Reb regulate the organisation of Kkv complexes at the apical membrane, which, in turn, regulates the function of Kkv in extracellular chitin translocation.

This study explores the relationship between spirituality in the corporate environment and corporate or organisational citizenship behaviour. The relationships amongst the sub-dimensions of workplace spirituality (meaningfulness of work, sense of community, alignment with organisational values) and the sub-dimensions of corporate or organisational citizenship behaviour (altruism, conscientiousness, sportsmanship, courtesy, civic virtue) are also examined. The extent to which the sub-dimensions of organisational citizenship behaviour predict workplace spirituality are analysed. The study was undertaken in a retail products outlet that focuses on quality and professionalism. The sample was drawn using cluster sampling and the adequacy of the sample was assessed using the Kaiser-Meyer-Olkin Measure and Bartlett’s Test of Sphericity. Data was collected using a closed-ended, established questionnaire and analysed using descriptive and inferential statistics. The results reflect that the organisation is fairly high on workplace spirituality with the focus being on meaningfulness of work and, on corporate or organisational citizenship behaviour with altruism and civic virtue being its greatest strength. There is a significant relationship between spirituality in the corporate environment and corporate or organisational citizenship behaviour, with sportsmanship and civic virtue being strong predictors of workplace spirituality. The results therefore, display the dynamic relationship between spirituality in the corporate environment and corporate or organisational citizenship behaviour, which when nurtured has the potential to enhance both bottom-lines of profits and people as well as society as a whole.

We have shown previously that intracellular phagosome movement requires microtubules. Here we provide evidence that within cells phagosomes display two different kinds of microtubule-based movements in approximately equal proportions. The first type occurs predominantly in the cell periphery, often shortly after the phagosome is formed, and at speeds below 0.1 microm/second. The second is faster (0.2-1.5 micron/second) and occurs mainly after phagosomes have reached the cell interior. Treating cells with nanomolar concentrations of taxol or nocodazole alters microtubule dynamics without affecting either total polymer mass or microtubule organisation. Such treatments slow the accumulation of phagosomes in the perinuclear region and reduce the number of slow movements by up to 50% without affecting the frequency of fast movements. This suggests that a proportion of slow movements are mediated by microtubule dynamics while fast movements are powered by microtubule motors. In macrophages, interphase microtubules radiate from the microtubule organising centre with their plus-end towards the cell periphery. To understand the behaviour of ‘early’ phagosomes at the cell periphery we investigated their ability to bind microtubule plus-ends in vitro. We show that early phagosomes have a strong preference for microtubule plus-ends, whereas ‘late’ phagosomes do not, and that plus-end affinity requires the presence of microtubule-associated proteins within cytosol. We suggest that phagosomes can bind to the plus-ends of dynamic microtubules and move by following their shrinkage or growth.

ABSTRACT Background: A language is an individual tool for stimulating and organizing concepts and thinking. Through a language, the individual is also given opportunities to understand the outside world and himself. Not having access to a functional language and means to communicate results in a potential loss of opportunities for development and limitations in all aspects of life. For individuals with language-, speech- and communication difficulties, there are Augmentative and Alternative Communication (AAC). AAC is a collective term for various tools and methods that aim to improve and facilitate communication and interaction between the individual and the persons surrounding them. One type of AAC is Pragmatic Organized Dynamic Display (PODD). Aim: This study aims to investigate what happens during interaction with PODD in conversations between two people using the methodology of Conversation Analysis (CA). Method: A qualitative case study was conducted during a day at a training school where an AAC user ("Adam") and his communication partner ("Elin) interacted with PODD in different everyday activities. The observation was documented with two video cameras. Result: The recorded material totaled three hours. From this amount of video material, a couple of sequences were selected for analysis. The analysis of the material shows that the interaction with PODD is built up sequentially through cooperation between the participants. Participants used different approaches to initiate, maintain and terminate communicative projects with PODD. The analysis also shows that PODD was used to perform various social actions within several different activity types. The results also indicate that it is the partner’s ability to pay attention to, interpret, support and guide the AAC user's communicative initiative, which gives the AAC user the opportunity to participate in the joint communicative projects.
SAMMANFATTNING Bakgrund: Ett språk är ett individuellt redskap för att stimulera och organisera begrepp och tänkande. Genom språket ges individen också möjligheter att förstå omvärlden och sig själv. Att inte ha tillgång till ett funktionellt språk och kommunikationssätt innebär att individen riskerar att gå miste om många utvecklingsmöjligheter och bli starkt begränsad i livets samtliga aspekter. För individer med språk, tal och kommunikationssvårigheter finns Alternativ och Kompletterande Kommunikation (AKK). AKK är ett samlingsbegrepp för olika redskap och metoder som avser att förbättra och underlätta kommunikation och interaktion mellan individen och personerna i dennes omgivning. En form av AKK är Pragmatisk Organiserad Dynamisk Display (PODD). Syfte: Denna studie syftar till att med metodologin för Conversation Analysis (CA) undersöka vad som sker i interaktion med PODD under samtal mellan två personer. Metod: En kvalitativ fallstudie som genomfördes under en dag på en träningsskola då en AKK-användare (”Adam”) och hans kommunikationspartner (”Elin) interagerade med PODD i vardagliga aktiviteter. Observationen dokumenterades med två videokameror. Resultat: Det inspelade materialet uppgick till totalt tre timmar. Utifrån denna mängd valdes ett par sekvenser ut för analys. Analysen av materialet visar att interaktionen med PODD byggs upp sekventiellt genom ömsesidigt samarbete mellan deltagarna. Deltagarna använde sig av olika tillvägagångssätt för att initiera, upprätthålla och avsluta kommunikativa projekt med PODD. Analysen visar även att PODD användes för att utföra olika sociala handlingar inom flera olika aktivitetstyper. Resultaten tyder också på att det är kommunikationspartnerns förmåga att uppmärksamma, tolka, stötta och vägleda AKK-användarens kommunikativa initiativ som ger AKK-användaren möjlighet att delta i det gemensamma kommunikativa projektet.