Dissertations / Theses on the topic 'Post-Cancer'
To see the other types of publications on this topic, follow the link: Post-Cancer.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Post-Cancer.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Moore, Julie. "Cancer and post-traumatic growth." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/171959/.
Abstract:
Cancer is a major medical problem and a leading cause of mortality in the UK. The experience of diagnosis and treatment can be a traumatic one for many people, with symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) common for many patients. Despite this, many survivors also report benefits and a sense of personal growth from their experience. Understanding this process and the influence of posttraumatic growth (PTG) on mental health outcomes for cancer patients may have far reaching implications for the promotion of psychological adjustment to this chronic illness. The literature review in this paper explores the predominant theories of PTG and the research on cancer-related PTG. The literature review explores links between the predictions of these general theories and research findings for cancer patients specifically. Establishing factors that predict PTG and its relationship with a range of mental health outcomes would help to build our understanding of emotional adjustment to chronic illness and inform the development of psychological interventions. The empirical paper investigates the role of trauma-related cognitive appraisals in the perception of PTG for breast cancer patients. More negative appraisals in relation to the event were associated with benefit finding.
2
Holland, C. M. "Genomic and post-genomic studies in endometrial cancer." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604158.
Abstract:
Genomic abnormalities lead to aberrant cell growth and signalling, contributing to the development of malignancy. Growth and metastasis also require the development of tumour vasculature. The VEGFs and angiopoietins are growth factor families central to this process. This thesis examines their expression in endometrial cancer. Genomic and post-genomic studies are used to broaden the investigation of angiogenesis and include related pathways. Using in situ hybridisation VEGF-A mRNA was detected in epithelial cancer cells but not pre-malignant and benign endometrium while VEGF-B was localised to both epithelial and stromal cells and was most abundant in benign endometrium. These findings suggest that VEGF-B may modulate the actions of VEGF-A by occupying receptors. Larger, gene microarray studies confirmed the differential expression of angiogenic factors and also identified a distinct set of coherently regulated genes in endometrial cancers. Within this gene set, PPARα, a transcription factor regulating fatty acid metabolism, was over-expressed in cancers unlike RXRβ, a heterodimerisation partner, which was down-regulated. A PPARα ligand altered proliferation and apoptosis of endometrial cancer cells suggesting that a normal PPARα/RXRβ ratio helps maintain cellular growth control. In conclusion, this work has defined the pattern of expression of the VEGF and angiopoieten families in endometrial cancer and identified VEGF-B as a possible modulator of VEGF-A action. Abnormalities of the fatty acid metabolic pathway have also been identified as a feature of endometrial cancer. Furthermore, an activating ligand for PPARα, a key factor in this pathway, exerted beneficial effects on the growth of endometrial cancer cells. PPARα ligands may therefore have therapeutic potential in endometrial cancer.
3
Simmons, Kingsley Lorraine. "The uptake of post-surgical treatment in cancer patients." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416863.
4
Ooi, Li Yin. "Post-GWAS functional characterisation of colorectal cancer risk loci." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23514.
Abstract:
Large bowel cancer, or colorectal cancer (CRC) is the third most common cause of cancer worldwide and the fourth biggest cause of cancer mortality. Twin studies have shown that the heritable contribution is ~35%, with ~5% of cases due to rare, high-penetrance mutations. In the last decade, the use of genome-wide association studies on large, well-characterised case-control cohorts of CRC has facilitated the identification of over 25 common genetic variants that carry with them an increased predisposition to colorectal cancer, invoking the common-disease common variant paradigm. As almost all of these variants lie within non-coding regions, the underlying causal mechanism is to-date poorly understood for the majority of these loci, and it is thought that they mediate risk by influencing gene expression levels. To test this hypothesis, an agnostic approach that utilises expression quantitative trait loci (eQTL) analysis was first carried on 115 normal colorectal mucosa samples and 59 peripheral blood mononuclear cells (PBMC). As these heritable variation on gene expression are likely to be subtle, there is a strong emphasis on the technical methodology to minimise experimentally-induced non-biological variations, including the extraction of high-quality RNA from primary tissue, the selection and validation of reference genes for normalisation of gene expression quantification, as well as internal validation of the samples and data processing. Thereafter, the association between the 25 CRC risk variants and the expression of their cis-genes were examined systematically, demonstrating that ten of these variants are also tissue-specific eQTLs. This intermediate phenotype strongly suggests that they confer risk, at least in part, by modifying regulatory mechanisms. One of the best eQTL associations (Xp22.2) is investigated in further detail to reveal a novel indel polymorphism (Indel24) at the distal promoter region of target gene SHROOM2 that influenced both transcript abundance and CRC risk more than the original tagging SNP. Functional verification with gene reporter assays indicated that Indel24 displays differential allelic control over transcriptional activity. Further in silico analysis and mutations to the reporter gene constructs provided evidence that Indel24 modulates transcription by modifying the spacing between CCAAT motifs and the consequent binding affinity of NF-Y transcription factor. siRNA depletion of NF-Y was associated with a reduction in transcriptional activity of the Indel24 gene construct as well as endogenous SHROOM2, which is strongly supportive of the interaction between Indel24 and NF-Y in the transcriptional activation of SHROOM2. Preliminary evidence is suggestive of SHROOM2 being expressed at the top of the intestinal epithelial crypt and playing a role in cell cycle regulation. Hypothesis-driven approaches can also be of utility in demonstrating functionality of CRC risk variants, complementing the hypothesis-free approach of eQTL analysis. Guided by a recently discovered gene-environment interaction between the 16q22.1 risk variant and circulating vitamin D levels, the influence of the rs9929218 SNP on CDH1 gene expression was examined, in relation to the expression of putative regulatory genes derived from in silico analysis and studies of other target genes. Although there was no direct association between rs9929218 and CDH1 expression, there were multiple two-way interactions that were together suggestive of rs9929218 influencing the VDR/FOXO4 regulation of CDH1. This provides functional support for the mechanism underlying the epidemiological observation of the gene-environment interaction between 16q22.1 and vitamin D, and demonstrates a candidate-based approach in deciphering the link between genetic locus and CRC susceptibility. In summary, the research presented in this thesis has validated the experimental rationale of utilising expression studies of normal colorectal mucosa to hone in on the molecular mechanisms and susceptibility genes underlying the association between common genetic variation and CRC risk.
5
Swartzman, Samantha. "Psychosocial determinants of post-traumatic stress among cancer survivors." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/10d5554d-8987-436b-9558-4e6be5f844f2.
Abstract:
Cancer survivors can experience a number of consequences of their disease, both physical and psychological. In this thesis, I aimed to clarify the psychosocial processes that reduce or increase post-traumatic stress after cancer. “Social support,” for instance, has often been linked to post-traumatic stress, but I describe several problems with this concept. Alternatively, inspired by the Social Identity Approach (SIA) to health, I proposed that group identification, or a sense of belonging and commonality with social groups, might predict levels of post-traumatic stress after cancer. In line with Social Cognitive Processing Theory (SCPT), I also proposed that cancer survivors’ perceptions that members of their social groups are closed, judgmental, and unreceptive in conversations about cancer (“group constraints”) might predict post-traumatic stress. I proposed that these constructs might act in tandem to predict levels of post-traumatic stress. To begin my programme of research, I conducted a meta-analysis that established factors contributing to post-traumatic stress disorder (PTSD). I also found an increased prevalence of PTSD among cancer survivors compared to controls without cancer. This meta-analysis demonstrated that cancer survivors can experience PTSD related to their illness. Subsequently, I undertook a series of quantitative questionnaire studies to establish psychosocial determinants of post-traumatic stress. My questionnaire included scales measuring post-traumatic stress, social support, group identification, and group constraints. In a pilot study, I used convenience sampling to test out the acceptability of the questionnaire and to provide a foundation for further hypothesising. Then, I distributed this piloted questionnaire to colorectal cancer survivors in Tayside. In initial “wave 1” cross-sectional analyses of this data, I found that social support was not an independent predictor of post-traumatic stress in multivariate analyses. However, group constraints consistently and independently predicted post-traumatic stress. Group identification exerted an effect on post-traumatic stress by reducing group constraints. I then distributed the same questionnaire a second time to the same respondents from wave 1 in order to collect longitudinal data. The results of the data from respondents at both waves 1 and 2 revealed that social support was, in fact, a likely causal predictor of post-traumatic stress. Constraints within the family also causally reduced post-traumatic stress. Family identification was a weak causal factor in reducing post-traumatic stress, but reciprocally, post-traumatic stress reduced group identifications. The longitudinal data also provided further, albeit not strong, support for the hypothesis that family identification reduces post-traumatic stress by reducing constraints on conversations within the family. Finally, in light of the consistent evidence from the quantitative studies above that conversational constraints are associated with increased post-traumatic stress, I conducted a qualitative interview study with a small number of cancer survivors aiming to characterise their experiences of conversations about cancer. The participants reported a broad range of experiences, beyond just constraints versus openness. These findings have broad implications for both theory and practice. For instance, in the final chapter, I discuss ways in which these results motivate further research on intersections between the Social Identity Approach and cancer-related post-traumatic stress. I also discuss implications for interventions going beyond traditional trauma exposure techniques.
6
Patel, Uday. "Post chemoradiation re-staging of rectal cancer using MRI." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/23905.
Abstract:
The role of MRI after preoperative treatment of rectal cancer is unclear. This thesis investigates its diagnostic relevance in patient management. Matching pathology with MR images aimed to characterise post treatment rectal cancer appearances on T2 weighted MRI and verify the proposed MRI tumour regression grading system(mrTRG). Correlation of post-chemoradiation mrTRG, T stage(ymrT), N stage(ymrN) and Circumferential Resection Margin(ymrCRM) with histopathological T stage(ypT), N stage (ypN), and pathological CRM(pCRM) was investigated. These parameters were also compared against survival outcomes. The alternative response assessment methods of tumour volume and length change/RECIST as well as mrTRG and ymrT were evaluated against pathology. The accuracy and reproducibility of MRI parameters in assessing rectal cancer response to neoadjuvant chemotherapy was also investigated. Patients with good response to chemoradiation(assessed by mrTRG) were enrolled into a deferral of surgery trial. Serial MRI-based monitoring enabled evaluation of quantitative imaging methods such as Apparent Diffusion Co-efficient (ADC) measurements in distinguishing tumour vs. complete response. Pathological fibrosis correlated with low signal on MRI, tumour was intermediate signal. mrTRG showed good diagnostic accuracy against ypT&pTRG, ymrT's diagnostic accuracy was fair but improved when grouped into favourable and unfavourable categories. MRI Length&volume assessment were less consistently related. Negative ymrN and potentially clear ymrCRM correlated well with their respective pathological endpoints. Importantly, mrTRG and ymrCRM involvement predicted survival outcomes. mrTRG showed good diagnostic accuracy against pTRG when assessing neoadjuvant chemotherapy response, ymrT correlated less well. Overall mrTRG and ymrT were the most reproducible parameters. ADC values were significantly lower in patients with tumour vs. complete response with ADC measurement of <1.3X10-3/mm2/sec associated with tumour regrowth in 86% of cases. mrTRG and MRI CRM assessment appear the most important post treatment imaging parameters. Grouped ymrT may also be useful. These parameters could be used by the multidisciplinary team to tailor treatment pre-operatively.
7
Wagner, Heidi. "Investigating post-translational modifications of c-Met in cancer." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203995/1/Heidi_Wagner_Thesis.pdf.
8
Longman, Michael Roy. "Combination of post-transcriptional and post-translational down-regulation of the oestrogen receptor in breast cancer." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/54416/.
Abstract:
Greater concentrations of fulvestrant are being employed within the clinic due to increased oestrogen receptor (ER) down-regulation and greater clinical benefit in ER+ breast cancer. However, complete ER down-regulation has not been achieved. The importance of residual ER is unknown and could allow cells to survive initial anti-hormone impact and progression to hormone insensitivity. This project aims to go further than current clinical therapy, using the MCF-7 cell model to target and assess the importance of residual ER. Cells were treated with fulvestrant aiming to achieve maximal ER down-regulation. The effect of any residual ER on signalling and growth was subsequently assessed. An alternative model for ER loss, ER siRNA, was employed to see whether this had a greater anti-ER effect. Finally, fulvestrant and ER siRNA were employed in combination to assess whether these agents work synergistically to give greater ER down-regulation and increased anti- tumour effect. With fulvestrant at 10"7M, ER levels were markedly reduced, although residual ER was observed that remained with increasing drug concentrations. There was significant reduction of ER signalling, proliferation and growth, but the inhibition was incomplete. When ER siRNA was assessed, similar results were obtained, with comparable and incomplete ER loss, residual signalling and growth. Following combination treatment of fulvestrant and ER siRNA, residual ER was almost undetectable, though this did not correspond to greater loss of ER signalling or growth when compared to either agent alone. While this work showed greater ER loss than previously recorded by targeting both protein and mRNA together, no greater anti-tumour activity was observed. Thus, while the mechanism underlying residual growth warrants future investigation (along with longer exposure), targeting ER alone, no matter how successfully, may not be the best treatment regimen and a combination of targets may be required as the optimum strategy to treat ER+ breast cancer.
9
Djordjevic, Darja. "The Cancer War(d): Onco-Nationhood in Post-Traumatic Rwanda." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493385.
Abstract:
In Africa, the effects of the HIV/AIDS pandemic, rapidly expanding industrial and extractive economies, uncontrolled economic growth, environmental and lifestyle changes, and the rising age of populations with better access to medicine have occasioned rising rates of cancer. Rwanda’s national cancer program has been hailed as a unique example of how to build clinical oncology into a public healthcare infrastructure. Using ethnographic data, interviews, and historical archives, I address three sets of questions: 1. What historical, economic, social, and political factors have shaped the development of the country’s cancer program? 2. How do local clinicians and patients experience cancer as a treatable chronic disease? And how is that experience affected by the development of a national oncology infrastructure and new biomedical technologies? 3. As an instance of the transnational private-public partnerships characteristic of global health interventions in postcolonial Africa, what successes, limitations, and challenges does this cancer program present for envisioning oncology programs elsewhere in the global south? What are the ethical, political, and epistemological stakes involved in different models of cancer care? This project contributes to a new chapter in medical anthropology, one focused on rising rates of cancer in contemporary Africa.
I argue that Rwanda’s cancer project is an exercise in the construction of a new sense of sovereignty, rendered through the politics of life as onco-nationhood; that it is an effort to create a postcolonial polity whose citizen body is gifted care of a international caliber provided by a paternal state. In a critical moment of post-traumatic social reconstruction, national biomedicine is becoming the entity through which government seeks to fuse sovereign statehood and nationhood in the cause of a healthy Rwandan future. Theorizing this relationship holds at least one key to developing an anthropology of cancer in contemporary Africa.Anthropology
10
Costanzo, Erin Susan. "Post-treatment adjustment and behavior change among women with breast cancer." Diss., University of Iowa, 2006. http://ir.uiowa.edu/etd/56.
11
Sebti, Salwa. "Rôle de la protéine BAT3 dans la signalisation cellulaire de l'autophagie." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T028.
Abstract:
L'autophagie est un processus d'autodigestion qui se produit dans toutes les cellules eucaryotes et conduit à la dégradation d'éléments du cytoplasme (organites, macromolécules) par le lysosome. Ce mécanisme, qui se produit de manière basale, permet le renouvellement du contenu cytoplasmique mais également la survie cellulaire lorsqu'il est induit par différents stress (carence nutritionnelle, hypoxie…). L'autophagie est alors impliquée dans diverses pathologies comme les maladies neurodégénératives et le cancer car sa dérégulation peut grandement perturber l'homéostasie cellulaire. Le but de ma thèse est de déterminer le rôle de la protéine nucléaire et cytoplasmique BAT3 dans l'autophagie et d'étudier son mécanisme de régulation. Cette protéine de 150 kDa, également appelée BAG6 ou Scythe, est composée de nombreux domaines protéiques (UBL, Prolin-rich, NLS, BAG) qui lui permettent d'interagir avec de multiples partenaires. Sa fonction majeure réside dans le contrôle qualité du cytoplasme mais BAT3 est aussi impliquée dans l'immunité ou l'apoptose. Ce travail identifie la protéine BAT3 comme essentiel pour l'autophagie basale et induite. Nous montrons que son mécanisme d'action passe par la régulation de la localisation de l'acétyltransférase p300 et l'acétylation de ces substrats : p53 et une protéine de la machinerie de l'autophagie : ATG7. En effet, BAT3 (i) limite la présence de p300 dans le cytosol en (ii) maintenant un faible et régulable niveau d'acétylation d'ATG7 et (iii) permet l'acétylation de p53 dans le noyau au cours de la carence nutritionnelle, événement indispensable à l'induction de l'autophagieAutophagy, literally meaning self-eating, is a highly evolutionary conserved process in eukaryotes in which parts of the cytoplasm (organelles, macromolecules) are degraded by lysosomes. Basal autophagy is a quality control mechanism allowing the renewal of the cytoplasm but autophagy is also induced by cellular stress (starvation, hypoxia…) to improve cell survival. Autophagy has been implicated in several physiopathologies such as cancer or neurodegenerative diseases. Deregulations of autophagy may profoundly affect homeostasis.The purpose of my thesis is to explore the role of the nucleo-cytoplasmic shuttling protein BAT3 in autophagy and the mechanism of BAT3-dependent autophagy.Also known as BAG6 or Scythe, this 150 kDa protein is composed of various domain (UBL, Prolin-Rich, NLS, BAG) by which BAT3 interacts with multiple partners. The major of role BAT3 seems to be the protein quality control but BAT3 is also implicated in immunity and apoptosis. Our work demonstrates that the protein BAT3 is essential for basal and starvation-induced autophagy. We show that BAT3 regulation of autophagy is mediated by the modulation of p300 acetyltransferase intracellular localization and acetylation of two subtrates: p53 and the autophagy-related protein ATG7. Indeed, Bat3 allows: (i) the limitation of p300 into cytosol resulting in (ii) the maintenance of a low level of ATG7 acetylation and (iii) the increase of the starvation-induced p53 autophagy leading to the induction of autophagy
12
Kyung, Chan Park. "Pleiotropic roles, post-translational regulation and pharmacological targeting of NDRG1 in cancer." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20146.
Abstract:
The metastasis suppressor, NDRG1, is a promising therapeutic target for cancer treatment. In past decade, much of the research has elucidated the anti-oncogenic molecular functions of NDRG1 in cancer cells. However, studies in some cancer-types revealed that this protein may have a pro-oncogenic role, leading to cancer progression. Although the studies on NDRG1 have been performed in diverse cancer-types, there was no clear explanation for the pleiotropic roles of NDRG1. Furthermore, the link between post-translational modification of NDRG1, its sub-cellular localisation and cellular regulation was not fully understood. Therefore, the studies in this thesis aimed to elucidate the role of NDRG1 post-translational modification and cellular localisation on its pleiotropic effects in cancer. Further, cellular processing of NDRG1 protein and its potential functional interaction with the proto-oncogene, c-Met, were investigated. To summarise the contents of this thesis, the results from Chapter 3 demonstrated that phosphorylation and truncation of NDRG1 protein could dictate its cellular localisation, but does not play an important role in pleiotropy. Data from Chapter 4 showed that NDRG1 protein is regulated by both the autophay- and proteasome-mediated pathways, which generate different NDRG1 isoforms. Finally, studies in Chapter 5 demonstrated that the proto-oncogene, c-Met, is potently down-regulated by the NDRG1-inducing anti-cancer agents, di-2-pyridylketone thiosemicarzones in cancer cells via two mechanisms involving lysosomal degradation and intracellular shedding, but this effect was NDRG1-independent. The investigations in this dissertation broaden our understanding of NDRG1 pleiotropy and cellular processing in tumour cells, as well as uncovering the suppressive effect of the di-2-pyridylketone thiosemicarbazones on c-Met expression.
13
Scott, Michael David. "Fluorescent Polymer Based Post-Translational Differentiation and Subtyping of Cancer Cells." Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26680.
Abstract:
The field of personalized medicine is focused on gathering information at a pre-translational level. Although this information is useful, it is becoming increasingly apparent that post-translational expression is not always consistent with that of the DNA or mRNA. Thus to advance personalized medicine, the development of additional technologies to gather disease state information at post-translational levels are necessary. This dissertation is focused on the advancement of fluorescent polymer technology to monitor at a secretomics level. Secretomics is a subset of proteomics that is focused on secreted proteins/enzymes from the cell. To monitor these secreted proteins, polymers were synthesized from the monomer state, with a polymerizable moiety of 4-vinylbenzoic acid. This compound was conjugated to various amino acids, alcohol derivatives, fluorophores, and metalloproteinase inhibitors. The monomer composition was thus varied to generate a library of polymers capable of forming unique interactions with proteins and enzymes. This polymeric library was screened against recombinant human MMP-7, -9, and -10. The fluorescent emissions data was subsequently evaluated using statistical analysis. This analysis provided information regarding an optimal polymer formulation for MMP isozyme specific interactions. This polymer was subsequently screened against both breast and prostate cancer cell conditioned media. This media were prepared such that the polymers would only interact with secreted proteins/enzymes (i.e. secretomics). Again fluorescence emissions data were evaluated using statistical analysis (linear discriminate analysis [LDA]) to demonstrate the polymer could distinguish between the subtypes, or sub-classification of the cancerous cells. Replacement of the fluorophore with a more hydrophilic pyranine improved the water solubility of the polymer. This polymer was thus screened against both the prostate and breast cancer conditioned media and evaluated using LDA. The results demonstrate an enhanced ability to distinguish and subtype the cancer cells. This dissertation will discuss an alternative mythology for the advancement of post-translational sub-typing with the intent to advance the field of personalized medicine.
14
Shatley, Joseph Andrew, and L. Lee Glenn. "Sexuality and Quality of Life of Breast Cancer Patients Post Mastectomy." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/7510.
Abstract:
Excerpt: Manganiello et al., (2010) aimed to evaluate the sexual functioning of mastectomy patients and its association with their quality of life. There are two shortcomings with this study that render its conclusions invalid, or at least, weakly supported.
15
Rivera, Vargas Thaiz Dayana. "La régulation post-transcriptionnelle des Cyclines D1, D3 et G1 par le complexe nucléaire IMP-3 dans les cancers humains." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T055.
Abstract:
La famille des protéines IMPs (IGF2 mRNA binding proteins) compte trois membres IMP1, 2 et 3. Les IMPs participent au développement embryonnaire. IMP1 et IMP3 sont considérées comme des protéines oncofoetales. En effet, malgré leur faible expression dans les tissus adultes, elles se retrouvent fortement surexprimées dans des cellules tumorales. Malgré la forte homologie entre les membres de la famille, les IMPs présentent des différences fonctionnelles qui restent très mal comprises jusqu’à présent. De nombreuses études montrent que la protéine IMP3 est très abondante dans de nombreux cancers tels que les carcinomes utérin, rénal, pulmonaire, les hépatocarcinomes et les rhabdomyosarcomes. Ces dernières années, IMP3 est devenu un marqueur de mauvais pronostique pour les patients atteins de cancer. Au cours de ma thèse j’ai principalement travaillé sur une lignée cellulaire de rhabdomyosarcomes (RMS). Les RMS sont des tumeurs principalement pédiatriques mais qui peuvent survenir à tout âge. En outre, la moitié des patients atteints des RMS meurent dans l'année suivant leur rechute et 90% des patients meurent dans les cinq ans suivant leur rechute. De nouvelles approches thérapeutiques sont absolument nécessaires. Mon sujet de thèse consiste à comprendre par quels mécanismes moléculaires les IMPs participent au processus oncogénique des RMS embryonnaires (eRMS). Pour cela, je me suis intéressée à la régulation des cyclines par les IMPs. Dans le cadre de mon projet, j’ai étudié l’effet des IMPs sur trois cyclines différentes : D1, D3 et G1. J’ai montré qu’IMP3, à la différence des deux autres, est capable de contrôler l’expression des cyclines D1, D3 et G1 dans les eRMS, ainsi que dans huit autres lignées de cancer humain différentes. Cette régulation a également des effets sur le cycle cellulaire des eRMS, expliquant l’importance d’IMP3 dans les cancers. Par diverses approches biochimiques, j’ai démontré que, sur les trois IMPs, seule IMP3 est très enrichie dans le noyau des eRMS, dans lequel elle forme des complexes avec les ARNm des CCND1, D3 et G1. Les différents résultats obtenus suggèrent un modèle selon lequel ces interactions au sein du noyau semblent indispensables à la régulation de la traduction des trois cyclines en protégeant leurs ARNm du complexe de silencing RISC (RNA induced silencing complex) et constituent donc la clé du mécanisme par lequel IMP3 contrôle la prolifération des cellules cancéreusesRNA-binding proteins of the IMP family (IGF2 mRNA-binding proteins 1-3) are key post-transcriptional regulatory factors of gene expression. They are known to control cell motility, adhesion, and proliferation. In our previous work, we show that all three IMP proteins can directly bind the mRNAs of cyclins D1, D3, and G1 (CCND1, D3, and G1) in vitro. Nevertheless, only IMP-3 regulates their expression in a significant manner in vivo, thus controlling proliferation of a number of human cancer cell lines. Importantly, the nuclear localization of IMP-3 is essential for the post-transcriptional regulation of the expression of CCND1, CCND3, and CCNG1 (CCNs). To elucidate the molecular mechanisms of IMP-3- specific regulation, we have identified its protein partners in human embryonic rhabdomyosarcoma (RMS) cells. We now show that in the nucleus and in the cytoplasm, IMP-3 interacts with a number or RNA-binding nucleocytoplasmic proteins, including DHX9, PTBP1, NF90, NF110, HNRNPA1, HNRNPA2/B1 and HuR. These IMP-3 partners have a dramatic impact on the protein levels of the cyclins. Interestingly, the decrease of CCNs protein synthesis in IMP-3 depleted cells can be fully reversed by down-regulating the key proteins of RNAi machinery, such as AGO2 and GW182. These findings suggest that IMP-3- dependent RNP complexes pre-assembled in the nucleus can protect their target mRNAs from cytoplasmic RNAi-dependent repression in human cancer cells
16
D'Urso, Anita. "Post-traumatic stress symptoms in young people with cancer and their siblings." Thesis, University of East Anglia, 2014. https://ueaeprints.uea.ac.uk/50725/.
Abstract:
Background: Children with cancer and their families are frequently confronted with physical and psychosocial late effects resulting from cancer. In recent years, this has been expanded to include posttraumatic stress symptoms (PTSS). However, to date very little research has been completed in the UK to investigate these symptoms. Furthermore, previous research has been limited by lack of adherence to mainstream theoretical accounts of posttraumatic stress disorder (PTSD). Therefore, the current study examined rates of PTSS in children with cancer and their siblings. Secondly, it investigated whether aspects of the Ehlers and Clark (2000) model of PTSD could provide a useful framework for understanding the phenomenon in this population. Methods: A cross-sectional between-groups design was employed to examine the differences in levels of PTSS between children who had been diagnosed with and/or treated for cancer (n = 34) and siblings (n = 26). Participants were aged between 8-18 years. Self-report measures of PTSS, maladaptive appraisals, traumacentred identity, thought suppression, perceived social support and family functioning were completed. Results: There were no significant differences between children with cancer and siblings on measures of PTSS. In support of the hypotheses, maladaptive appraisals, thought suppression and trauma-centred identity were found to significantly correlate with levels of PTSS for both children with cancer and siblings. Perceived social support was found to be significantly correlated with levels of PTSS for siblings only. Contrary to the hypothesis, family functioning was not related to PTSS for either the patient or sibling group. Conclusions: Results failed to evidence differences in levels of PTSS between children with cancer and their siblings. However, provisional support was found for aspects of the Ehlers and Clark (2000) cognitive model of PTSD in explaining PTSS for the current population.
17
Owusu, Miriam Sekyere. "Lymphedema, post breast cancer treatment at Komfo Anokye Teaching Hospital, Kumasi, Ghana." Thesis, Cape Peninsula University of Technology, 2011. http://hdl.handle.net/20.500.11838/2262.
Abstract:
Thesis (MTech (Nursing))--Cape Peninsula University of Technology, 2011.To determine the incidence, risk factors and the treatment of lymphedema after breast cancer treatment at the oncology unit of KATH, Kumasi, Ghana from 01 January 2005 to 31 December 2008. Descriptive retrospective survey was used. Using a data capture sheet, data was collected from the medical records of the breast cancer patients. Breast cancer and lymphedema-related variables were collected. Data was analyzed as descriptive statistics. Chi-square test was applied to determine whether or not two variables are independent variables. Among 313 patients treated for breast cancer between 2005 and 2008, 31 (9.9%) developed lymphedema after treatment. A chi-square test showed that axillary lymph node dissection was statistically a significant risk factor of lymphedema (Chi-square test value=7.055, P value=0.008). Radiation and late stage of breast cancer diagnosis may have contributed in development of lymphedema despite having P value> 0.05. Age, body mass index (BMI) and hypertension were also not associated with lymphedema.
18
Chand, Manish. "The prognostic role of extramural venous invasion in post-chemoradiotherapy rectal cancer." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/31467.
Abstract:
Introduction Extramural venous invasion (EMVI) is a poor prognostic factor in rectal cancer. It is detected by magnetic resonance imaging (MRI) and histopathological analysis. Neoadjuvant chemoradiotherapy (CRT) is often given to patients with locally advanced disease however the clinical outcomes of EMVI-positive tumours following such treatment remains unknown. This thesis aimed to investigate the radiological, pathological and molecular changes which occur in EMVI-positive tumours following CRT to determine whether these changes can predict prognosis. Methods Following a systematic review (SR) of EMVI in rectal cancer, a series of studies were conducted. Patients were identified from a prospectively maintained database of primary rectal cancers who were scheduled for CRT followed by curative surgery between 2006 and 2012. Imaging and pathology samples were reviewed and tissue samples were further processed for molecular profiling using micro-RNA analytical techniques. Data were correlated with disease-free survival (DFS), recurrence rate and patterns of relapse. Results SR demonstrated that EMVI is associated with locally advanced tumours, distant disease recurrence and worse overall survival. However there is a variation in technique and definitions which makes interpretation of historical studies problematic. EMVI is an important consideration in the multidisciplinary management of rectal cancer as most clinicians use it to influence treatment decisions. MRI may allow for improved detection rates of EMVI following CRT compared with routine histopathology techniques and it is an independent prognostic factor for recurrence at 3 years. Patients with persistent EMVI following CRT have improved DFS if given adjuvant chemotherapy. Finally, EMVI-positive tumours express specific patterns of microRNA sequences. Conclusion EMVI is a poor prognostic factor following CRT. Patients with evidence of EMVI may be considered for intensive adjuvant chemotherapy and more frequent surveillance for distant disease. Unique molecular signatures may hold the key for future management strategies. These results have led to the development of the MARVEL Study.
19
BELLAZZO, ARIANNA. "Tumor Suppressor DAB2IP as a target for post-transcriptional inactivation in cancer." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908029.
Abstract:
The intricate network established among cancer cells and their microenvironment, strongly affect cancer progression.
The tumor suppressor DAB2IP (Disable homolog 2 interacting protein), also known as AIP1 (ASK1 interacting protein), is an essential factor in this context, since it modulates signal transduction by several growth factors and inflammatory cytokines, affecting cancer cells’ behavior. Importantly, DAB2IP modulates TNF alpha signaling in endothelial and cancer cells sustaining the activation of the pro-apoptotic JNK/ASK1 pathway, while counteracting the activation of the NF-kB. Moreover, acting as a scaffold protein, this tumor suppressor counteracts the activation of other oncogenic pathways, exerting an important control on epithelial-to mesenchymal transition (EMT), migration, and survival of tumor cells. In summary, behaving as a guardian of signal transduction in tumor cells, DAB2IP can be considered a cytoplasmic tumor suppressor.
Despite significant knowledge on its molecular function, little is known about its regulation. DAB2IP is rarely mutated, but it is epigenetically silenced in different types of tumors. In addition, other molecular mechanism might exist in cancer to counteract the tumor suppressive activity of this protein. Therefore, their identification could provide novel therapeutic and diagnostic strategies against tumors.
Point mutations of the TP53 gene represent a significant factor in cancer progression. In this Thesis, I report data demonstrating that mutp53 binds DAB2IP in the cytoplasm of tumor cells, counteracting its inhibitory role on NF-kB and blocking the activation of JNK pathway. I demonstrate that mutp53, through the interaction with DAB2IP, reprograms tumor cell response to TNF, sustaining a pro-invasive behavior and counteracting apoptosis. Notably, this action is coupled to an increased expression of chemokines that can expose tumor cells to host immunity, potentially affecting response to therapy and patient outcome.
We hypothesize that other conditions that would impair DAB2IP protein levels - or function - could promote tumor progression. Its potentially represents a good target for microRNAs (miRNA)-mediated regulation. Up to known, 2 miRNAs regulating DAB2IP (miR-338-5p and miR-889) have been reported, in a model of neuronal differentiation and in esophageal squamous cells carcinoma. To discover additional DAB2IP-targeting miRNAs, we functionally screened a large collection of human miRNA mimics. Among several hits, we identified one miRNA showing strongly ability to down-regulate DAB2IP protein levels in multiple transformed cell lines. In this Thesis I report how this miRNA can affects DAB2IP protein levels in tumor cells, the activation of pathways downstream DAB2IP and increasing invasiveness of cancer cells. The DAB2IP inhibitory activity exerted by miRNA can be blocked using specific inhibitors, or target protectors, thus reducing aggressive phenotypes of cancer cells. These results suggest that the inhibition of miRNA oncogenic activity, and the consequent rescue of DAB2IP protein levels in cancer cells could potentially represent a mechanism to affect tumor progression and outcome.
20
Wall, David P. "Responding to localised prostate cancer : Lifeworld reconstruction during the first post-diagnostic year." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2005. https://ro.ecu.edu.au/theses/655.
Abstract:
This thesis investigated the experiences of men diagnosed with localised prostate cancer, as they reconstructed their lifeworlds during the first post-diagnostic year. With the exception of health related quality of life, a review of the psychosocial research literature revealed few studies that, explored the psychosocial experience of men diagnosed with localised prostate cancer. Furthermore, the review uncovered no studies that explored the process of Iifeworld reconstruction, and only three studies that considered the role of masculinity in the responses of men to the prostate cancer experience. Such a limited understanding, about the nature and process of lifeworld reconstruction, potentially compromises the provision of gender appropriate care by health care professionals. Therefore, providing an improved understanding of men's evolving responses to localised prostate cancer is important for the development of gender appropriate care that is lifeworld compatible. The purpose of this study was to contribute to an improved understanding of men's emotional, relational, and existential engagements with the prostate cancer experience, by providing an in-depth descriptive account of the process of lifeworld reconstruction.
21
Hockett, Keri Ann. "The effects of a comprehensive post-treatment recovery program for breast cancer survivors." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001256.
22
Askwith, Bryn Catherine. "Post-treatment exercise counseling and programming preferences of women living with breast cancer." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31655.
Abstract:
Background: The 5-year overall survival rate for women with early detected breast cancer is
87%. Many of these women, however, live with physical and psychosocial sequelae from
breast cancer and its treatments. Health care needs of this growing population have fueled
research on cancer survivorship including interventions, such as exercise, that can lead to
improved quality of life (QOL). Nevertheless, despite demonstrated physical, mental and
QOL benefits of exercise among persons with breast cancer, low levels of adoption and
adherence remain a reality.
Study Aim: The purpose of this descriptive study was to identify the exercise counseling
and programming preferences of women who have completed treatments for breast cancer in
British Columbia (BC).
Methods: A self-administered questionnaire (SAQ) was mailed to 472 randomly selected
women living with stage 0,1, II or III breast cancer, greater than 3 months post-treatment.
The 54-item questionnaire identified exercise behaviours, counseling and programming
preferences, demographic and medical variables. Descriptive statistics were used to analyze
study data.
Results: Overall, 70% of participants preferred or maybe preferred to receive exercise
counseling at some point during their cancer experience. The majority of respondents
preferred to receive exercise counseling face to face (87%), from an exercise specialist
affiliated with a cancer centre (60%). As for exercise program preferences, the greatest number of respondents preferred walking (46%), at a moderate-intensity (66%), outdoors
(33%). Sixty-three percent of participants were interested or maybe interested in regularly
attending (at least 3 times/week) an exercise program for women living with breast cancer.
Discussion and Conclusions: Although a majority of respondents were interested in some
type of exercise, results from this study indicate that women living with breast cancer who
are post-treatment have unique exercise preferences. Accounting for these preferences when
creating and prescribing exercise programs for women living with breast cancer may result in
increased adoption and long-term adherence. Preferences to receive in-person exercise
counseling and to begin a moderate-intensity exercise program following treatment offer a
realistic starting point for women to adopt a lifelong pattern of exercise. Implications for
cancer care professionals are explored and recommendations are provided for future research.Medicine, Faculty of
Graduate
23
Djoki´c, Tamara. "Identification of predictive models for treatment of neutropenia in post-chemotherapy cancer patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0020/MQ54615.pdf.
24
Colbourne, Linda Claire. "Testicular and prostate cancer : explaining the treatment and post treatment experience of couples." Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419165.
25
Steyn, Beatrix Hendrina. "Surviving a laryngectomy : the experiences of post-operative cancer patients and their families." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95872.
Abstract:
Thesis (PhD)--Stellenbosch University, 2014.ENGLISH ABSTRACT: Post-operative laryngectomy patients face various physical, psychological and social challenges. The comprehensive effects of a total laryngectomy can have an adverse impact on the patient and his or her family. Because improved medical treatment can increase the life expectancy of cancer sufferers, psychosocial guidance is required over an extended period. Unfortunately, limited information on the coping strategies of such patients is available. The social work profession could benefit from greater insight into the strengths and coping mechanisms of post-operative cancer patients in order to guide them through their survivorship journey with insight and compassion. The researcher therefore aimed to explore and describe the experience of a patient and his/her close family while coping with the long-term challenges of a laryngectomy. The objectives were: (1) to discuss the nature of cancer survivorship, (2) to describe the medical aspects of and physical re-adjustments to a laryngectomy, (3) to discuss principles and strategies for coping and surviving a laryngectomy, (4) to describe the comprehensive psychosocial effects during the permanent survival phase and re-entry into society; (5) to explore the survivorship journey of laryngectomy patients and their families, and (6) to analyse and interpret data obtained from the study. Each of the survivorship phases as contextualised by Miller et al. (2008:369-374)* is discussed in the literature review. Both the ecological and the strengths perspective were utilised as the theoretical framework for this study. Principles of the strengths perspective focus on the inherent strengths that help patients cope with this traumatic life event, while the ecological perspective focuses on the utilisation of community resources in order to survive the laryngectomy experience. A combination of exploratory and descriptive designs was applied throughout the study to gain insight into the survival experience of post-operative laryngectomy patients and their families. The research question was: “What are patients’ and families’ experiences of surviving a laryngectomy with the assistance of internal and external resources within the family system and environment?” This question was addressed by combining the quantitative and qualitative research approaches. Forty-five post laryngectomy patients and fifteen family members, representing one-third of these patients, were included in the study through purposive sampling. The study period was from June 2012 to July 2013. The inclusion criteria required: (1) Patients from the service area of the selected hospital who received a total laryngectomy as surgical treatment for an advanced stage of cancer of the larynx or hypopharynx; (2) patients who were operated on not less than three months previously; (3) patients who had already completed their initial treatment and who were attending the follow-up clinic; and (4) patients who had successfully acquired trachea-oesophageal speech. Data obtained from the interviews were organised into themes. Four themes were identified: (1) the need for pre-operative information; (2) experience of physical adjustment; (3) coping and strengths used; and (4) experience of psychosocial effects of surgery and re-entry into society. These themes were divided into sub-themes and categories. The main outcome of the study was that both patients and families mobilise a combination of inner strengths and external resources to adapt to the inevitable physical changes resulting from a laryngectomy. It is therefore recommended that social workers dealing with survivorship cases utilise a combination of the ecological and strengths perspectives to create an environment in which patients can explore their own inner strengths, or to help them link to community resources whilst coping with their survivorship journey. Future research should focus on the long-term psychosocial survival of laryngectomy patients and their families, as it is likely that survivorship will increase in future; the implementation of survivorship programmes for health care professionals to equip them with skills to guide cancer survivors to full utilisation of their own strengths and available community resources; the role of pre- and primary school children/grandchildren in the rehabilitation of laryngectomy patients deserves further investigation.
AFRIKAANSE OPSOMMING: Laringektomie-pasiënte word ná hul operasie met verskeie liggaamlike, psigiese en sosiale uitdagings gekonfronteer. Die omvattende gevolge van ‘n totale laringektomie kan die pasiënt en sy of haar gesin nadelig affekteer. Aangesien verbeterde mediese behandeling die lewensverwagting van kankerpasiënte kan verleng, word psigososiale ondersteuning oor ‘n langer tydperk benodig. Ongelukkig bestaan daar baie min inligting oor hoe pasiënte kanker hanteer. Die maatskaplike werk beroep kan dus voordeel trek uit beter insig in die hanteringsmeganismes van post-operatiewe kankerpasiënte om hulle met insig en empatie deur hul oorlewingsreis te kan begelei. Die navorser het ten doel gehad om die ondervindings van die kankerpasiënt en sy/haar naby familie tydens hul langtermynhantering van ‘n laringektomie te ondersoek en te beskrywe. Verdere oogmerke van die studie was: (1) om die aard van kankeroorlewing te bespreek; (2) om die mediese aspekte van en liggaamlike aanpassing ná ‘n laringektomie te beskrywe; (3) om die beginsels en strategieë vir ‘n oorwinning oor ‘n laringektomie te bespreek; (4) om die omvattende psigososiale gevolge van die finale oorlewingsfase en hertoetrede tot die gemeenskap te beskrywe; (5) om die oorlewingsreis van die laringektomiepasiënt en sy/haar gesin te ondersoek; en (6) om die resultate van die studie te ontleed en te interpreteer. Elk van die oorlewingsfases soos deur Miller et al. (2008:369-374)* beskrywe, is in die literatuuroorsig bespreek. Die ekologiese en die sterkte-perspektiewe is tesame as teoretiese raamwerk vir die studie gebruik. Die beginsels van die sterkte-perspektief is op die inherente krag van pasiënte gemik, om te bepaal hoe hulle hierdie traumatiese lewensgebeurtenis hanteer, terwyl die ekologiese perspektief op hul aanwending van gemeenskapsbronne om die laringektomie te oorleef, fokus. ‘n Kombinasie van ondersoekende en beskrywende navorsings ontwerpe is deurgaans gebruik om insig in die oorlewingstryd van laringektomiepasiënte en hul gesinne te verkry. Die navorsingsvraag was: “Wat is pasiënte en hul gesinne se ervarings van oorlewing na ‘n laringektomie met die hulp van interne en eksterne hulpbronne in die gesinstruktuur en omgewing?” Kwantitatiewe en kwalitatiewe navorsingsmetodes is gekombineer om hierdie vraag te ondersoek. Vyf-en-veertig laringektomiepasiënte en vyftien gesinslede, wat verteenwoordigend van twee-derdes van die pasiënte was, is met behulp van ‘n doelbewuste steekproef by die studie betrek. Die studie is tussen Junie 2012 en Julie 2013 onderneem. Die insluitingskriteria was: Pasiënte uit die diensgebied van die spesifieke hospitaal wat 'n totale laringektomie as chirurgiese behandeling vir 'n gevorderde stadium van kanker van die larinks of hipofarinks ontvang het; (2) pasiënte wat hul operasie nie meer as drie maande vantevore ondergaan het nie, (3) pasiënte wat reeds hul aanvanklike behandeling voltooi het en wat die opvolgkliniek bywoon, (4) pasiënte wat tragea-esofageale spraak suksesvol bemeester het. Die data, wat deur middel van onderhoude ingesamel is, is in temas gegroepeer. Vier temas is geïdentifiseer: (1) die behoefte aan inligting voor die operasie; (2) ervaring van liggaamlike aanpassing; (3) die hantering van omstandighede en innerlike krag; en (4) ervaring van die psigososiale uitwerking van die operasie en hertoetrede tot die gemeenskap. Hierdie temas is verder in subtemas en kategorieë verdeel. Die belangrikste uitkoms van hierdie studie is dat beide pasiënte en gesinne ‘n kombinasie van hul innerlike krag en eksterne bronne aangewend het om ná die laringektomie by die onafwendbare liggaamlike veranderinge aan te pas. Daar word dus aanbeveel dat maatskaplike werkers wat kankeroorlewendes hanteer, van ‘n kombinasie van die ekologiese en die sterkte-perspektief gebruik maak om ‘n omgewing te skep waarin die pasiënt sy of haar eie innerlike krag kan ontgin, of om pasiënte te help om kontak met gemeenskapsbronne te maak terwyl hulle die oorlewingsreis baasraak. Toekomstige navorsing behoort te fokus op langtermyn psigososiale oorlewing van laringektomie pasiënte en familie met inagneming van die tendens dat kanker pasiënte se oorlewing toeneem; die implementering van opleidingsprogramme vir gesondheidswerkers te fokus om hulle met die nodige kennis toe te rus om kankeroorlewendes te begelei om hul volle krag en alle beskikbare gemeenskapsbronne te gebruik. Daarby verdien die rol van voorskoolse- en laerskoolkinders in die rehabilitasie van laringektomiepasiënte verdere ondersoek.
26
Elgamal, Ola A. "TRANSCRIPTIONAL AND POST TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION: APPLICATIONS TO BIOLOGY AND CANCER." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461071345.
27
Mosquet, Guillaume. "L'analgésie post-opératoire par bupivacaïne interpleurale dans la chirurgie du cancer de l'oesophage." Caen, 1991. http://www.theses.fr/1991CAEN3128.
28
Allensworth-Davies, Donald. "Assessing localized prostate cancer post-treatment quality of life outcomes among gay men." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12263.
Abstract:
Thesis (Ph.D.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.Background: An estimated 2.3 million prostate cancer survivors reside in the United States, 50,000-70,000 of which are gay men. Fearing discrimination, stigma, or receipt of substandard care, gay men may not reveal their sexual orientation potentially affecting provider communication, treatment decision-making and post-treatment quality of life (QoL). Sexual orientation and other social factors may play an important role in men's QoL. Research suggests that functional impairments following treatment diminish QoL more for younger (i.e., age 50-64 years) than older men, while supportive partners can positively influence how men adapt to prostate cancer. Yet data are currently limited to heterosexual populations; it is unknown whether these effects are similar among gay prostate cancer survivors. Aims: To revise recent measures of prostate cancer QoL to include the experiences of gay men, assess the role of age and partnership status among gay men and compare QoL between gay and straight men. Methods: We administered a national QoL survey to gay prostate cancer survivors, including questions about sexual orientation disclosure and community rejection derived from qualitative interviews. Survey data were analyzed to assess the role of age and partnership status among gay men for four post-treatment prostate cancer QoL outcomes (masculine self-esteem, health worry, informed treatment decision and treatment regret) and QoL was then compared to straight prostate cancer survivors using data from a previous study to assess for differences based on sexual orientation. Results: Younger gay men experienced poorer QoL outcomes following treatment than older men; no association with partnership status was found. Comfort in revealing one's sexual orientation to a provider may result in better outcomes. Gay men reported more stigma, lower masculine self-esteem and more treatment regret following prostate cancer treatment than straight men. Conclusions: For gay men, greater sensitivity to stigma as a sexual minority may result in poorer QoL compared to straight men. While both gay and straight men struggle with similar QoL issues following localized prostate cancer treatment, gay men may have more difficulty due to sexual orientation. Further research is needed to better understand the role that sexual orientation and stigma play in prostate cancer QoL.
29
Rajandram, Rama Krsna. "Posttraumatic growth in oral cancer patients: a novel coping strategy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661691.
30
EL, Dhaybi Mohamad. "Déterminants moléculaires non-apoptotiques de l'activité oncogénique de Bcl-xL : rôle de la monodéamidation de Bcl-xL." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0034/document.
Abstract:
Bcl-xL est un oncogène surexprimé dans plusieurs types de cancers et qui joue un rôle important dans la survie cellulaire en régulant deux processus: l'apoptose et l'autophagie. Récemment, nous avons identifié l'existence d'une nouvelle forme de Bcl-xL qui subit une simple déamidation sur le résidu Asn52. Cette forme monodéamidée est exprimée en conditions contrôles et apparaît spontanément in vitro et in vivo. La déamidation de Bcl-xL produit un mélange de protéines contenant en position 52 soit un résidu Asp, soit un résidu isoAsp. L'objectif de cette thèse est de caractériser les fonctions de ces deux espèces protéiques, et de déterminer comment la monodéamidation de Bcl-xL modifie les fonctions de survie de cet oncogène. Nous avons montré que le mutant déamido-mimétique Bcl-xL N52DN66A conserve la même fonction anti-apoptotique que Bcl-xL native, mais présente une activité autophagique plus grande, et des propriétés oncogéniques et tumorigéniques altérées in vitro, ex vivo et in vivo. Nous avons étudié certains des mécanismes impliqués dans la régulation de l'autophagie et les propriétés oncogéniques comme la voie mTor, les voies de signalisation médiées par l'oncogène Ras, ainsi que l'activité métabolique et l'état souche des cellules. D'autre part, nous avons aussi développé des tests in vitro pour analyser les interactions établies par les formes déamidées de Bcl-xL comportant un isoAsp. L'ensemble de nos données permet de suggérer une régulation des fonctions de Bcl-xL par des mécanismes indépendants de l'apoptose, et renforce l'importance d'explorer les fonctions non apoptotiques de cette protéine pour mettre en évidence sa capacité à promouvoir la survie cellulaire et entraîner la progression du cancerBcl-xL is an oncogene overexpressed in many types of cancer and which promotes cell survival by regulating two cellular processes : apoptosis and autophagy. We have recently identified a new form of this oncogene, which results from the deamidation of Asn52. This monodeamidated form is expressed under control conditions and is ubiquitously found in vitro and in vivo. Bcl-xL monodeamidation produces a mixture of proteins containing either an Asp residue or an IsoAsp residue in position 52. Our goal is to caracterise the functions of both species, and to determine how Bcl-xL monodeamidation modifies the survival functions of this oncogene. We have shown that the deamidomimetic mutant Bcl-xL N52DN66A retains the same anti-apoptotic function as the native protein, but exhibits enhanced autophagic activity and impaired clonogenic and tumorigenic properties in vitro, ex-vivo, and in vivo. We have studied certain of the mechanisms which can be involved in the regulation of autophagy and oncogenic properties of Bcl-xL such as mTor, Ras oncogene signaling pathway, metabolic activity measurement and stemness. We also implement in vitro assays to analyse the interactions established by isoAsp containing forms of Bcl-xL. Altogether our results support the view that deamidation regulates Bcl-xL oncogenic properties through apoptosis-independent mechanisms, and reinforce the importance of deciphering the non apoptotic functions of this protein to tackle its ability to sustain cell survival and drivecancer progression
31
Gouverneur, Amandine Andrée Denise Suzanne. "Evaluation post-commercialisation des médicaments en oncogériatrie : application au traitement du cancer colorectal métastatique." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0887/document.
Abstract:
En France, en 2012, les sujets âgés d’au moins 65 ans représentaient 71 % de l’incidence du Cancer ColoRectal (CCR). Depuis 2005, des thérapies ciblées ont été autorisées dans le CCR métastatique (CCRm) et sont recommandées en 1ère ligne en association à une chimiothérapie. Face à un manque d’évaluation de ces médicaments chez le sujet âgé, l’objectif de ce travail était l’étude, en situation réelle de soins, de l’utilisation, des bénéfices et de la sécurité d'emploi des médicaments anticancéreux, dont les thérapies ciblées, chez le sujet âgé et/ou fragile atteint de CCRm. Une revue systématique de la littérature a confirmé la faible inclusion des sujets âgés et fragiles dans les essais cliniques évaluant les thérapies ciblées dans le CCRm. D’après une étude sur des données mondiales de pharmacovigilance et la réunion de deux cohortes de terrain de patients traités par thérapies ciblées, nous avons montré que leur effectivité et sécurité d’emploi chez le sujet âgé étaient équivalentes à celles du sujet plus jeune. Dans la cohorte, la fragilité vis-à-vis des effets indésirables graves et du décès était liée aux caractéristiques du CCRm. Enfin, d’après une étude de terrain pilote et une cohorte dans les données de l’Assurance Maladie française, nous avons montré que, chez le sujet âgé, le traitement par médicaments anticancéreux, dont les thérapies ciblées, n’était pas optimal et encore très lié à l’âge des patients. Le rapport bénéfices/risques des thérapies ciblées semble donc positif dans la population âgée atteinte de CCRm actuellement traitée. Cependant, la population âgée traitée ne semble pas encore totalement correspondre à celle qui pourrait bénéficier du traitementIn France, in 2012, patients aged at least 65 years accounted for 71% of the incidence of ColoRectal Cancer (CCR). Since 2005, targeted therapies have been authorized in metastatic CRC (mCRC) and are recommended in first-line in combination with conventional chemotherapy. Given this lack of evaluation of these drugs in the elderly, the objective of this work was the study, in real-life setting, of the use, the benefits and the safety of anticancer drugs, including targeted therapies in elderly and/or frail mCRC patients. A systematic review of the literature confirmed the low inclusion of elderly and frail patients in clinical trials evaluating targeted therapies in the mCRC. According to a study on international pharmacovigilance data and the pooling of two field cohorts of patients treated by targeted therapies, we showed that their effectiveness and safety in the elderly were equivalent to those of the younger. In the cohort, frailty regarding serious adverse events and death was related to the characteristics of the mCRC. Finally, according to a pilot field study and a cohort in the French health insurance data, we have shown that, in the elderly, the treatment with anticancer drugs, including targeted therapies, was not optimal and still very related to the age of the patients. The benefit/risk ratio of targeted therapies therefore seems positive in the elderly population with mCRC currently treated. However, the elderly population treated does not seem to be fully matching with those who would benefit from treatment
32
JAMET, SERGE. "Les sarcomes post-radiques de la region thoracique apres irradiation pour cancer du sein." Nice, 1988. http://www.theses.fr/1988NICE6519.
33
Nduka, Charles. "Operative dissemination of cancer : the impact of microenvironmental manipulation on post-operative tumour growth." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391634.
34
Redwood, Katie. "An exploration of gender differences in post-traumatic growth in survivors of colorectal cancer." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/381737/.
35
Lelorain, Sophie. "Qualité de vie et développement post-traumatique à long terme d'un cancer du sein." Nantes, 2009. http://www.theses.fr/2009NANT3034.
Abstract:
Cette recherche a pour objectifs de décrire et surtout d'expliquer de décrire et surtout d'expliquer la qualité de vie et le développement post-traumatique (changements positifs psychologiques vécus suite à un événement de vie difficile) de femmes étant actuellemnt de 5 à 15 ans du diagnostic d'un cancer du sein, en comparaison avec d'autres n'ayant pas eu le acncer et faisant référence à l'événement le plus difficile vécu dans les 15 dernières années de leur vie. Méthode : cette étude transversale a été menée par questionnaires auprès de 307 femmes ayant eu le cancer et 132 femmes constituant une position contrôle. Des entretiens semi-directifs, conduits auprès de 28 femmes anciennement cancéreuses ont complété les questionnaires dans l'appréhension du développement post-traumatiques après le cancer. Résultats : La qualité de vie des femmes à long terme du cancer est satisfaisante et comparable à celle de la population contrôle. Bien que des changements positifs soient effectivement déclarés, ils ne semblent pas spécifiques au cancer. Dans les deux populations, la qualité de vie mentale dépend essentiellement de la personnalité et du soutien perçu, la qualité de vie physique de variables sociodémographiques, médicales et des séquelles laissées par l'événement, le développement post-traumatique du coping. Conclusion : dans l'ensemble et à long terme, le cancer ne paraît pas plus délétère que d'autres événements difficiles sur la qualité de vie. Il convient néanmoins de ne pas minimiser l'impact d'un cancer du sein dans la vie d'une femme.
36
Farashi, Samaneh. "Identification and characterisation of prostate cancer-associated genetic variations modulating the miRNA regulome." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/210596/1/Samaneh_Farashi_Thesis.pdf.
Abstract:
This thesis has studied the genetic regions that are associated with the risk of prostate cancer. The results from this thesis provide insights into causative miRNA genes that contribute to prostate cancer. The identified prostate cancer risk regions in the genome have valuable potential in utilising in investigating pathogenic mechanisms in prostate cancer. This greatly helps with a broader range of treatment options according to the targetable gene networks and pathways. As the elderly population increases in Australia, the social and economic consequences of prostate cancer will increase unless successful means of prevention or treatment are found.
37
Lacourt, Luis Eduardo. "A Phenomenological Exploration into the Resiliency of Prostate Cancer Survivors." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/4971.
Abstract:
Scholarly articles related to the physical and emotional effects of prostate cancer treatment and survivorship are abundant. However, few researchers have explored resiliency of prostate cancer survivors through their recovery and survivorship experience. There is a gap in the literature regarding resilience through the lived experiences of prostate cancer survivors. Counselor educators could be better prepared to teach counselors to promote the resilience needs of prostate cancer survivors. The purpose of this hermeneutic phenomenological qualitative study was to explore and describe the lived experiences of prostate cancer survivors. Coding analysis of data collected from interviews of 7 participants generated 3 major themes and 30 subthemes of experiences. Themes included experiences and feelings surrounding the cancer diagnosis, descriptions of resilience, and the personal growth the participants gained from their experiences. The results of this study give voice to their challenges and offer insight into how prostate cancer survivors find meaning while adapting constructively to adversity and resilience. A clearer understanding of these experiences may promote understanding of the prostate cancer experience for men, offer insight for promoting resilience among prostate cancer survivors, and give clues to the experiences of other populations responding to cancer.
38
Johnson, Frank Phillip. "The impact of ablative facial cancer surgery and the affect of post-operative facial prostheses." Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/12865/.
Abstract:
This thesis examines psychosocial issues experienced by participants following a diagnosis of facial malignancy and ablative cancer surgery of the face. It investigates how participants felt about surgery and the affect that the use of postoperative facial prostheses had on each participant. Semi-structured interviews were used to capture participants' experiences of treatment. Interpretative Phenomenological Analysis (Smith 2004; Smith, Flowers & Larkin 2009) was used to perform a content analysis of the data which revealed themes and sub-themes common to all participants. Ethical approval was granted for the inclusion of up to eight participants in the study. Initially twenty participants were randomly selected and contacted by letter. Thirteen individuals agreed to their inclusion in the study and eight were randomly selected for inclusion and contacted by letter. The five individuals not selected were contacted and thanked. Interviewing ceased after the sixth participant had been interviewed n=6 after no new themes relative to the study were discovered. Some findings of the research were congruent with previous research. A supportive partner and family group make coping easier. Professional attendants who listen and allow individuals to talk have a positive impact. Findings specific to this study suggest that facial prostheses are useful after ablative cancer surgery of the face. Prostheses restore outward normality which was important for reasons of social acceptability. However, the study found that feelings of normality were not restored This concluded with a re-definition of normality for disfigured patients who use a facial prosthesis to incorporate the wider context revealed by the study.
39
Wilson, Fiona. "Developing a decision aid for women considering post-treatment CA-125 testing for ovarian cancer." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/26045.
Abstract:
Aims: This thesis had three aims: to review evidence evaluating the effectiveness of decision aids at increasing cancer patients’ treatment-related knowledge and reducing decisional conflict; to explore the decision-making processes of ovarian cancer patients who had opted for or against CA-125 testing during post-treatment surveillance; and to elicit patients’ and health professionals’ views on the proposed development of a decision aid aimed at helping women decide for or against CA-125 testing during post-treatment surveillance for ovarian cancer. Methods: A systematic review was conducted of evidence relating to the effectiveness of cancer treatment-related decision aids at increasing treatment-related knowledge and reducing decisional conflict. In the qualitative study, semi-structured interviews were conducted with ovarian cancer patients (n = 18) and health professionals (n = 6) in an outpatient gynecological oncology clinic. Framework analysis was used to identify themes in the qualitative data. Results: Overall, results from the systematic review supported previous research where decision aids were found to improve patient knowledge and reduce decisional conflict across a range of cancer treatment-related decisions. However, the lack of psychometric support for the treatment-related knowledge measures used in the majority of the studies compromised their ability to address the review question. In the qualitative study, accurate knowledge about CA-125 testing in post-treatment surveillance was found to greatly influence participants’ decision-making processes. Most women with less knowledge about the test chose to have testing based on the false belief that earlier detection of recurrence would lead to earlier treatment and prolonged survival. There was strong enthusiasm from patients and health professionals for the development of the proposed decision aid to assist women facing this treatment decision. Conclusions: The systematic review findings add to previous research supporting the use of decision aids in cancer-related treatment decisions and advocate for their continued development, evaluation and implementation into the healthcare system. The need for a decision aid to ensure accurate knowledge about CA-125 and to aid decision-making for women with ovarian cancer was supported. As well as assisting women with this decision, the proposed decision aid may ultimately support health professionals in practicing shared decision-making regarding CA-125 testing with ovarian cancer patients.
40
Banthia, Rajni. "Post-treatment fatigue in breast cancer survivors : the role of sleep quality and depressed mood /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3130213.
41
Garcia, Amandine. "Régulation, par les microARNs, des gènes de prédisposition au cancer du sein BRCA." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10159.
Abstract:
Une absence ou une réduction de l’expression des gènes de prédisposition au cancer du sein BRCA1 et BRCA2 est retrouvée dans un tiers des cancers du sein sporadiques. Cependant, les mécanismes entraînant une inactivation de leur expression déjà identifiés comme la présence de mutations somatiques, l’hyperméthylation de leur promoteur ou encore la perte d’hétérozygotie (LOH) ne suffisent pas, à eux-seuls, à expliquer cette forte diminution. Nous avons donc émis l’hypothèse d’une régulation de l’expression des gènes BRCA par les microARNs (miR). Suite à une analyse bioinformatique, validée par des tests luciférase, nous avons montré l’interaction directe de miR-146a et miR-146b-5p avec la 3’UTR de BRCA1. Ces miRs diminuent le taux de protéine BRCA1 lors de leur surexpression et l’augmentent lors de leur inhibition. Nous avons montré également le rôle joué par ces miRs dans la prolifération cellulaire et dans la réparation par recombinaison homologue, fonctions pour lesquelles BRCA1 est requise. Nous avons retrouvé ces 2 miRs surexprimés dans les lignées mammaires et les tumeurs triple-négatives qui ont un profil semblable aux tumeurs développées chez les porteuses de mutations BRCA1. Dans une deuxième partie nous avons analysé si ces deux microARNs jouaient aussi un rôle dans les cancers du sein familiaux. Notre étude du SNP rs2910164 : G>C situé dans le gène de miR-146a, nous a permis de montrer que sa présence ne modifie pas le risque de développer un cancer du sein chez les porteuses de mutation BRCA1 et BRCA2. Nous avons également entrepris de rechercher si certains gènes codant pour des miRs pouvaient être de nouveaux gènes modificateurs du risque tumoral chez les porteuses BRCA, et/ou de nouveaux allèles de prédisposition au cancer du seinAn absence or a reduction of the expression of the BRCA1 and BRCA2 breast cancer predisposition genes is found in one third of sporadic breast cancers. However, the mechanisms leading to the inactivation of their expression that have been already identified like the presence of somatic mutations, hypermethylation of the promoter or loss of heterozygosity at the BRCA loci are not sufficient to explain this large diminution. We therefore hypothesised that the expression of the BRCA genes could be regulated by microRNAs (miR). Following a bioinformatics analysis, validated by luciferase tests, we have shown a direct interaction of miR-146a and miR-146-b-5p with the 3’UTR of BRCA1. These miRs decrease the BRCA1 protein rate when they are overexpressed and increase it when they are inhibited. Furthermore we have demonstrated the role played by these miRs in cell proliferation and DNA repair by homologous recombination, two mechanisms for which BRCA1 is required. We have found these two miRs overexpressed in mammary cell lines and in triple-negative breast tumors that have a profile similar to that of the tumors developed by BRCA1 mutation carriers. In a second part, we analysed if these two microRNAs also play a role in familial breast cancers. An association study of the rs2910164 : G>C SNP located in the gene for miR-146a, has permitted us to show that its presence does not seem to modify the risk to develop breast cancer in BRCA1 and BRCA2 mutation carriers. We have also undertaken to determine if some miR genes could modify tumor risk in BRCA mutation carriers, and/or could represent new breast cancer predisposing alleles
42
Bellera, Carine A. "Hierarchical changepoint modeling of post-radiotherapy prostate-specific antigen (PSA) series in men with prostate cancer." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100321.
Abstract:
Prostate-specific antigens (PSA) help monitor the post-therapy course of prostate cancer. If radiotherapy is successful, levels reach a nadir, and remain low or possibly rise very slowly. A sustained steep increase indicates biochemical failure.Serial PSA measurements are rarely perfectly monotonic. The American Society for Therapeutic Radiology and Oncology (ASTRO) consensus panel defines biochemical failure as three consecutive PSA increases. I examined the sensitivity and specificity of the ASTRO criterion using simulations of realistic, sophisticated data sets, that accurately reflect the systematic and random variations observed in PSA series.
In a preliminary analysis, I estimated the underlying PSA trajectories in a cohort of 470 men treated with radiotherapy for localized prostate cancer. I exploited the flexibility of Bayesian hierarchical regression models to describe the individual PSA series, each with its own changepoint, and non-constant variance.
The estimates provided by the hierarchical model allowed me to simulate a large set of true PSA series. From these, I generated observed PSA series: each underlying PSA value was distorted by adding a realistic amount of 'noise'. To evaluate the performance of rules for biochemical failure, including the ASTRO criterion, I then compared the generated observed PSA series to the underlying true PSA series. My results suggest that another rule might outperform ASTRO. This simulation-based approach can be applied to evaluate other rules that purport to rapidly and accurately detect up (down) turns in noisy series, such as in other medical data, and in data series used to monitor economic trends.
Finally, I present a practical charting paper for physicians to record post-treatment PSA values of individual patients. The plotted serial values provide rapid and accurate estimates of the PSA doubling time, without any difficult computations.
43
Grant, Andriene Simone. "The Association between Hemoglobin Level and Cancer Incidence, Mortality and Inflammatory Biomarkers in Post-Menopausal Women." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/301693.
Abstract:
Background: Knowledge regarding the associations of (i) hemoglobin level (Hb) prior to cancer diagnosis and cancer mortality (ii) the full range of Hb and cancer incidence and (iii) baseline inflammatory/other biomarkers and Hb in older populations is limited. The present study examined the associations of anemia status/Hb with cancer incidence and mortality, as well as the association with inflammatory biomarker levels in post-menopausal women. Methods: Anemia was defined as Hb <1 2 g/dl, while high Hb was defined as Hb >= 15 g/dl, or >= 16 g/dl. Associations were determined in three Women's Health Initiative Study sub-populations. The association between anemia/Hb with cancer mortality was determined in women without (N=21,021) or with (N=2,976) cancer history who had cancers on follow-up. The cross-sectional association of biomarkers and anemia/Hb was determined on 1,001 women with these available data. Finally, the association between anemia/Hb with cancer incidence was determined in women enrolled in the Observational Study/Clinical Trial who did not have a history of cancer/extreme energy intakes/missing follow-up time (N=140,269). Results: Anemia was associated with a 21% higher hazard of total cancer death in participants with, and a 55% greater hazard in participants without cancer history. Anemic women with a history of cancer had twice the hazard of colorectal cancer death. C-reactive protein, TNF-alpha, TNF-beta and TNFR2 were significantly associated with anemia. IL-1 alpha and IL-10 were significantly associated with continuous Hb. Anemia was not associated with cancer incidence in the total population, but anemic African-American women had a reduced risk of any cancer incidence which was not observed in white women (p-interaction=0.03). Women with high Hb had an increased hazard of any (HR: 1.37; 95% CI: 1.17, 1.60) or breast cancer (HR: 1.42; 95% CI: 1.10, 1.84) incidence. Conclusions: Anemia determined prior to cancer diagnosis was associated with total and colorectal cancer death. High Hb was associated with increased risk of total cancer and breast cancer incidence. Anemia was associated with elevated levels of C-reactive protein, TNF-alpha, TNF-beta and TNFR2, while continuous Hb was associated with IL-1 alpha and IL-10. Further research is required to confirm associations and clarify causal mechanisms.
44
Buttiglione, V. "THE ROLE OF MIR-340 IN POST-TRANSCRIPTIONAL REGULATION OF THE UPA-SYSTEM IN BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365720.
Abstract:
The urokinase-type plasminogen activator system (uPA-system), whose main components are the serine protease uPA (PLAU), the cell surface receptor uPAR (PLAUR) and the uPA inhibitor PAI-1 (SERPINE1), has been extensively studied for its involvement in cancer pathogenesis. Specifically, nowadays the components of the uPA-system are well-characterised determinants for the prognosis of breast cancer. The regulation of the gene expression of the uPA-system components is very complex and depends on a plethora of stimuli acting both at transcriptional and post-transcriptional level. The uPA-system components are often over expressed in breast cancer but the detailed molecular mechanisms regulating the expression are still to uncover. In an expression analysis conducted on a cohort of unselected breast cancer patients, we found that the expression of PLAU and PLAUR is highly correlated. Meta-analyses of published experimental data and in silico studies pointed out the possibility that PLAU, PLAUR and also SERPINE1 might be negatively regulated at post-transcriptional level by a microRNA, the miR-340. We experimentally validated the role of miR-340 as negative regulator of the expression of the three uPA-system components using MDA-MB-231, a triple negative breast cancer cell line. Microarray experiments, performed to characterise the global transcriptome changes induced by miR-340 in MDA-MB-231 cells, showed that miR-340 down regulates also the expression of desmoplastic reaction-related genes underlining a possible role of miR-340 in regulating tumour-associated genes. Notably, most of the identified miR-340 target genes were found indeed to be associated with poor clinical outcome in breast cancer. Functional studies carried out in MDA-MB-231 cells suggested that miR-340 might modulate cell proliferation, even if this effect was not confirmed in vivo. In order to better define the functional role of miR-340, we generated a miR-340 deficient mouse model, taken advantage of the zinc finger nuclease technology. Overall these data identify, for the first time, a single microRNA that is able to down regulate the expression of the three main components of the uPA-system together with desmoplastic reaction and breast cancer prognosis-related genes, thus representing a new potential player in the pathogenesis of breast cancer.
45
Lagauche, Jacqueline. "Résultats de la radiothérapie post-opératoire dans le traitement du cancer de l'endomètre stade 1 : étude d'une série de 89 cas." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25318.
46
Bombil, Ifongo. "Incidental cancer in multinodular goiter post thyroidectomy." Thesis, 2015. http://hdl.handle.net/10539/18473.
Abstract:
A report submitted to the Faculty of Health Science, University of Witwatersrand for
the Degree of Mastery of Medicine (Surgery)
JOHANNESBURG 2015The risk of malignancy in the background of multinodular goitre (MNG) approximates 7.2%. The gold standard for diagnosis of thyroid cancer is fine needle aspiration (FNA). Unsuccessful, inconclusive or suspicious result mandate further investigations. The concern is on benign FNA which would not necessitate thyroidectomy but carries a risk of missed malignancy. Aim To determine the percentage and histopathological subtype of incidental cancers in patients who had thyroidectomy for multinodular goitre (MNG). Method Records of patients who underwent thyroidectomy between January 2005 and December 2010 at Chris Hani Baragwanath Academic Hospital were retrospectively reviewed. Data retrieved included patients’ demography, type of thyroidectomy, thyroid function test, FNA cytology and final histopathological results. Results A total of 166 thyroidectomies were performed on 162 patients. Majority (139) of patients were females. The mean age was 46 years (ranging from 15 to 79 years). A total of 120 pre-operative FNAs were available for analysis and 78 FNA were suggestive of benign nodular goitre. 70 of benign FNA results were histologically confirmed to be MNG after thyroidectomy. Incidental malignancy was found in 4 out of 70 cases of MNG (5.7 %); all were papillary carcinomas and predominantly (75%) follicular variant. Conclusion The risk of missing cancer in the background of MNG was 5.7%. The commonest histological type of thyroid cancer found in MNG was papillary carcinoma (100%) with follicular variant being the most common subtype (75%).
47
Wu, Timothy H., and 巫孟叡. "Integrative Cancer Marker Discovery in Post Genomic Era." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/90774634090036442043.
Abstract:
碩士國立陽明大學
生物資訊研究所
94
Expressed Sequence Tags (ESTs) are cDNA sequences reverse transcribed from mRNAs, reflecting the gene transcript at the time of extraction. Thus, ESTs offer a tremendous amount of information valuable for gene profiling. As of the year 2006, the database of EST at NCBI (dbEST) hosts more than 7 million human cDNA sequences, invaluable for mining differentially expressed genes from various cancer tissues. Here, a new approach for expression profile is presented. Unlike the existing EST database mining tools, our method bypass common problems associated with EST clustering techniques and is more flexible in dataset selection and the final selection of significant genes. A number of known cancer markers were easily found in our analysis. In general, this new technology will be useful for the identification of previously uncharacterized genes and may be helpful for developing cancer diagnosis and therapeutic agents.
48
Schmidtmann, Frank. "Co- and post-translational synthesis towards carbohydrate based cancer vaccines /." 2005. http://wwwlib.umi.com/dissertations/fullcit/3149206.
49
Jing-HongGuo and 郭勁宏. "MicroRNAs Mediate Post-transcriptional Regulation of Pin1 in Prostate Cancer." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/07279735601378536767.
50
Rocha, Rafael Amorim. "Histone post-translational modifications and chromatin remodelers in colorectal cancer." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/109416.