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1

Umberto, Bracco, Deckelbaum Richard J, and Nestlé Nutrition Services, eds. Polyunsaturated fatty acids in human nutrition. New York: Raven Press, 1992.

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2

Hudson, Elizabeth Ann. Polyunsaturated fatty acids in tumour-induced cachexia. Birmingham: Aston University. Department of Pharmaceutical Sciences, 1993.

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3

Bernhard, Maisch, and Oelze R, eds. Cardiovascular benefits of omega-3 polyunsaturated fatty acids. Amsterdam: IOS Press, 2006.

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4

Calviello, Gabriella, and Simona Serini, eds. Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-3579-0.

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5

1933-, Simopoulos Artemis P., Kifer Robert R, Martin Roy E, National Institutes of Health (U.S.). Nutrition Coordinating Committee., and National Fisheries Institute, eds. Health effects of polyunsaturated fatty acids in seafoods. Orlando: Academic Press, 1986.

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6

Calviello, Gabriella. Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer. Dordrecht: Springer Science+Business Media B.V., 2010.

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7

International, Conference on the Health Effects of [omega]3 Polyunsaturated Fatty Acids in Seafoods (2nd 1990 Washington D. C. ). Health effects of [omega]3 polyunsaturated fatty acids in seafoods. Basel: Karger, 1991.

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8

International Conference on the Health Effects of [omega]3 Polyunsaturated Fatty Acids in Seafoods (2nd 1990 Washington, D.C.). Health effects of [omega]3 polyunsaturated fatty acids in seafoods. Edited by Simopoulos Artemis P. Basel: Karger, 1990.

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9

Lieberman, Pamela. Response of brain and heart mitochondrial cardiolipin fatty acid profiles to alterations in dietary polyunsaturated fatty acids. Ottawa: National Library of Canada, 1991.

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10

T, Diplock Anthony, Gutteridge John M. C, and Shukla Vijai K. S, eds. Antioxidants, free radicals and polyunsaturated fatty acids in biology and medicine. Lystrup, Denmark: International Food Science Centre, 1993.

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11

Lands, William E. M., 1930- and American Oil Chemists' Society, eds. Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids. Champaign, Ill: American Oil Chemists' Society, 1987.

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12

Tadao, Yasugi, Hakamura Haruo, and Soma Masayoshi, eds. Advances in polyunsaturated fatty acid research: Proceedings of the 5th Scientific Meeting of the Society for Research on Polyunsaturated Fatty Acids (PUFA), Tokyo, 11-14 November 1992. Amsterdam: Excerpta Medica, 1993.

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13

Bowles, Robert David. Production of n-3 polyunsaturated fatty acids by thraustochytrids: Physiology and optimisation. Portsmouth: University of Portsmouth, School of Biological Sciences, 1997.

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14

Services, United States Specialized Information. Effects of fish oils and polyunsaturated omega-3 fatty acids in health and disease. Bethesda, MD: National Institute of Health, 1995.

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15

Das, Undurti N. A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain Polyunsaturated Fatty Acids. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4419-8564-4.

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16

Carlson, Susan E. Assessment of infant visual and cognitive function in relation to long chain polyunsaturated fatty acids. Basel: Editiones Roche, 1996.

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17

A perinatal strategy for preventing adult disease: The role of long-chain polyunsaturated fatty acids. Boston, Mass: Kluwer Academic Publishers, 2002.

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18

McCabe, Anthony J. The role of polyunsaturated fatty acids on the expression and production of matrix metalloproteinases and their inhibitors. [S.l: The Author], 1999.

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19

Hussey, Helen Jayne. Polyunsaturated fatty acid requirements of murine colon adenocarcinomas. Birmingham: Aston University. Department of Chemical Engineering an d Applied Chemistry, 1996.

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20

Pique, G. G. Omega-6: Excess polyunsaturate folly : new diet oil/fiber heart health. San Diego, CA: Omega-3 Project, 1988.

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21

Slater, Joanne Lesley. A molecular study of n-3 polyunsaturated fatty acid production by Thraustochytrium striatum. Portsmouth: University of Portsmouth, School of Biological Sciences, 2001.

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22

Horrobin. Polyunsaturated Fatty Acids. University of Cambridge ESOL Examinations, 2002.

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23

Company, Nestle, and Nestle Nutrition Workshop. Polyunsaturated Fatty Acids in Human Nutrition. Books on Demand, 1992.

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24

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Polyunsaturated fatty acids in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0005.

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Evidence for the importance of the long-chain omega-3 polyunsaturated fatty acids in fetal and infant development is growing, as is interest in what constitutes an appropriate intake from sources such as oily fish or dietary supplements for pregnant women and/or infants. Polyunsaturated fatty acids have been implicated in maternal mental health and aspects of infant development, including cognitive and visual function, adiposity, and allergy. Western diets have become imbalanced with regard to the ratio of omega-6:omega-3 fatty acids, and recommendations to correct this imbalance include increasing the maternal intake of oily fish. However, this recommendation needs to be evaluated in light of the increased risk of exposure to contaminants such as mercury. Vegetable oils and cereals are important sources of polyunsaturated fatty acids for vegetarians.
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25

Simopoulos, Artemis P. Health Effects of Polyunsaturated Fatty Acids in Seafoods. Elsevier Science & Technology Books, 2012.

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26

Health Effects of Polyunsaturated Fatty Acids in Seafoods. Elsevier, 1986. http://dx.doi.org/10.1016/c2012-0-01660-2.

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27

McConn, Michele. Mutants of Arabidopsis deficient in polyunsaturated fatty acids. 1994.

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28

Soma, Masayoshi. Advances in Polyunsaturated Fatty Acids: Proceedings of the 5th Scientific Meeting of the Society for Research on Polyunsaturated Fatty Acids . Tokyo, 11-14 November 1992. Routledge, 1993.

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29

Catala, Angel. Polyunsaturated Fatty Acids: Sources, Antioxidant Properties and Health Benefits. Nova Science Publishers, Incorporated, 2013.

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30

Catala, Angel, and Angelica Catalani. Polyunsaturated Fatty Acids: Food Sources, Health Effects and Significance in Biochemistry. Nova Science Publishers, Incorporated, 2018.

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31

Rodriguez-Cruz, Maricela, and Mardia Lopez-Alarcon, eds. Latest Finding of Omega-3 Long Chain-Polyunsaturated Fatty Acids. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/97816080517791110101.

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32

Yasugi, Tadao, and Haruo Nakamura. Advances in Polyunsaturated Fatty Acid Research: Proceedings of the 5th Scientific Meeting of the Society for Research on Polyunsaturated Fatty Acid (International Congress Series). Excerpta Medica, 1993.

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33

Cardiovascular Benefits of Omega-3 Polyunsaturated Fatty Acids: Volume 7 Solvay Pharmaceuticals Conferences. IOS Press, 2007.

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34

Debicki, Donna Monica. Electrophysiological effects of long chain omega-3 polyunsaturated fatty acids in rabbits in vivo. 2005.

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35

Das, Undurti N. Perinatal Strategy for Preventing Adult Disease: The Role of Long-Chain Polyunsaturated Fatty Acids. Springer, 2012.

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36

Das, Undurti N. Perinatal Strategy for Preventing Adult Disease: The Role of Long-Chain Polyunsaturated Fatty Acids. Springer London, Limited, 2011.

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37

Simopoulos, Artemis, ed. Health Effects Of W3 Polyunsaturated Fatty Acids In Seafoods (WORLD REVIEW OF NUTRITION & DIETETICS). Karger, 1991.

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38

Silflow, Ronald Mark. Effects of omega-3 polyunsaturated fatty acids on bovine alveolar macrophages infected with parainfluenza virus, type 3. 1992.

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39

Das, Undurti N. A Perinatal Strategy for Preventing Adult Disease: The Role of Long-Chain Polyunsaturated Fatty Acids. Springer, 2002.

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40

Yang, Jilin. Zinc deficiency in the pregnant rat affects maternal and fetal metabolism of polyunsaturated fatty acids. 1994.

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41

Billman, George E., ed. The Effects of Omega-3 Polyunsaturated Fatty Acids on Cardiac Rhythm: Antiarrhythmic, Proarrhythmic, Both or Neither? Frontiers Media SA, 2013. http://dx.doi.org/10.3389/978-2-88919-088-1.

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42

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Vitamin B7 (biotin) in pregnancy and breastfeeding. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0011.

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Biotin is a water-soluble B vitamin (vitamin B7) which acts as a coenzyme to carboxylases and has roles in gluconeogenesis, fatty acid synthesis, and amino acid catabolism. Reduced activity of biotin-dependent enzymes (acetyl-CoA carboxylase I and II, and propionyl-CoA carboxylase) alters lipid metabolism and may impair synthesis of polyunsaturated fatty acids and prostaglandins; in addition, biotin has effects on gene expression by binding covalently to histones. Deficiency can be caused by prolonged consumption of egg whites, which contain the biotin-binding protein avidin. Smoking accelerates the degradation of biotin, which can result in marginal biotin deficiency. The effects of deficiency include disruption of immune function and lipid metabolism, with some evidence of teratogenicity in animals. Dietary deficiency is unlikely, although high consumption of egg whites should be avoided in pregnancy.
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43

Rodriguez-Saona, Luis Enrique. Peroxidase and lipoxygenase activities and their effect on the stability of polyunsaturated fatty acids in two different varieties of sweet corn (Zea mays L.), Jubilee and GH 2684, during frozen storage. 1993.

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44

Polyunsaturated Fatty Acid Metabolism. Elsevier, 2018. http://dx.doi.org/10.1016/c2016-0-00749-0.

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45

Burdge, Graham C. Polyunsaturated Fatty Acid Metabolism. AOCS, 2018.

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46

Bender, David A. 8. Functional foods, superfoods, and supplements. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199681921.003.0008.

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When a vitamin or mineral deficiency is widespread in a population, a common approach is to enrich or fortify a staple food. ‘Functional foods, superfoods, and supplements’ defines functional foods as foods that contain one or more added ingredients to provide a positive health benefit, over and above the normal functions of food to provide nutrients and satisfy hunger. Superfoods are ordinary foods that are especially rich in nutrients or antioxidants and other potentially protective compounds, including polyunsaturated fatty acids and dietary fibre. ‘Nutritional supplements’ covers a wide range of preparations which are regarded as foods rather than medicines, and in most countries are regulated under food rather than under medicinal legislation.
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47

Dupuis, Nina, and Stéphane Auvin. Anti-Inflammatory Effects of a Ketogenic Diet. Edited by Jong M. Rho. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0017.

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The high-fat, low-carbohydrate ketogenic diet (KD) is an established and proven treatment for pharmacoresistant epilepsy. Recently, the KD is being explored for some inflammation-induced epileptic encephalopathies. Given the broad neuroprotective properties of the KD in various experimental models of neurological disorders, there are yet additional potential future uses. Consistent with this, there is growing evidence that the KD exerts anti-inflammatory activity. Ketone bodies, caloric restriction, and polyunsaturated fatty acids might be involved in the modulation of inflammation by the KD. This chapter reviews the evidence that, in part through anti-inflammatory effects, the KD holds promise in the treatment of certain epileptic disorders, neuropathic pain, multiple sclerosis, and Parkinson’s disease.
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48

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Practicalities: understanding nutrient recommendations. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0003.

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There has been much research in recent years on the nutritional requirements of mothers during pregnancy, as well as an increasing focus on the nutrition of women before conception. Because there has been much confusion with regards to some nutrients such as vitamin D, iron, and polyunsaturated fatty acids, the second section of this book contains specific advice, based on an in-depth interpretation of the current clinical and scientific literature, on macro- and micronutrient dietary components and their effects on pregnancy and lactation outcomes. This chapter provides an introduction for the subsequent chapters in this section by discussing the practicalities of understanding nutrient recommendations. The chapter also gives an overview of the terms used by various agencies to describe nutrient requirements. In addition, the chapter goes into detail about food labelling standards from the US, Canada, the UK, Australia, and New Zealand.
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49

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Macronutrients and fibre requirements during pregnancy. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0004.

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In this chapter, the impact of varying intakes of protein, carbohydrate and lipids, which are the key nutrients that contribute to calorie intake, is examined. Fibre is also an important food component that needs to be considered. The maternal macronutrient profile can influence embryonic and fetal development. For instance, both low and excessively high protein intakes during pregnancy are associated with restricted growth, increased adiposity, and impaired glucose tolerance. High-fat maternal diets can significantly increase the susceptibility to diet-induced obesity and percentage total body fat in offspring, although types of fats need to be considered, as intake of polyunsaturated fatty acids is important for fetal development. The type and content of carbohydrate (high- vs low-glycaemic sources) in the maternal diet influences blood glucose concentration, which has a direct effect on fetal glucose levels and metabolism.
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50

Gluckman, Sir Peter, Mark Hanson, Chong Yap Seng, and Anne Bardsley. Guidelines for pregnancy. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198722700.003.0037.

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If a pregnant woman has not had pre-conception counselling, it is important to ensure as soon as possible in early pregnancy that she understands her nutrient requirements, and what comprises a balanced diet and healthy body composition. The advice should include weight gain goals in pregnancy, a list of unsafe foods, healthy exercise behaviours, and the effects of alcohol and drugs. Energy intake needs in early pregnancy do not increase from pre-pregnancy levels; women should focus on eating well for pregnancy, and not eating more. Specific attention should be paid to intakes of folate, vitamin A, vitamin B12, vitamin D, iron, and iodine. Glucose status should be monitored in mid-pregnancy. Energy requirements increase in mid- to late pregnancy, but attention should also be paid to the macronutrient balance. If the diet is low in oily fish as a source of polyunsaturated fatty acids, supplementation should be considered.
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