Journal articles on the topic 'Polypharmacological'
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Garcia-Romero, Ezra Michelet, Edgar López-López, Catalina Soriano-Correa, José L. Medina-Franco, and Carolina Barrientos-Salcedo. "Polypharmacological drug design opportunities against Parkinson's disease." F1000Research 11 (October 17, 2022): 1176. http://dx.doi.org/10.12688/f1000research.124160.1.
Full textPeragovics, Agnes, Zoltan Simon, Andras Malnasi-Csizmadia, and Andreas Bender. "Modeling Polypharmacological Profiles by Affinity Fingerprinting." Current Pharmaceutical Design 22, no. 46 (January 24, 2017): 6885–94. http://dx.doi.org/10.2174/1381612822666160831104718.
Full textSchneider, Petra, and Gisbert Schneider. "Polypharmacological Drug−target Inference for Chemogenomics." Molecular Informatics 37, no. 9-10 (May 24, 2018): 1800050. http://dx.doi.org/10.1002/minf.201800050.
Full textSeki, Hajime, Song Xue, Mark S. Hixon, Sabine Pellett, Marek Remes̆, Eric A. Johnson, and Kim D. Janda. "Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity." Chemical Communications 51, no. 28 (2015): 6226–29. http://dx.doi.org/10.1039/c5cc00677e.
Full textSchneider, P., M. Röthlisberger, D. Reker, and G. Schneider. "Spotting and designing promiscuous ligands for drug discovery." Chemical Communications 52, no. 6 (2016): 1135–38. http://dx.doi.org/10.1039/c5cc07506h.
Full textBesnard, Jérémy, Gian Filippo Ruda, Vincent Setola, Keren Abecassis, Ramona M. Rodriguiz, Xi-Ping Huang, Suzanne Norval, et al. "Automated design of ligands to polypharmacological profiles." Nature 492, no. 7428 (December 2012): 215–20. http://dx.doi.org/10.1038/nature11691.
Full textVitali, Francesca, Francesca Mulas, Pietro Marini, and Riccardo Bellazzi. "Network-based target ranking for polypharmacological therapies." Journal of Biomedical Informatics 46, no. 5 (October 2013): 876–81. http://dx.doi.org/10.1016/j.jbi.2013.06.015.
Full textGao, Lanchang, Chao Hao, Ru Ma, Jiali Chen, Guisen Zhang, and Yin Chen. "Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics." RSC Advances 11, no. 28 (2021): 16931–41. http://dx.doi.org/10.1039/d1ra02426d.
Full textLi, Hongchun, Fen Pei, D. Lansing Taylor, and Ivet Bahar. "QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics." Bioinformatics 36, no. 12 (March 28, 2020): 3935–37. http://dx.doi.org/10.1093/bioinformatics/btaa210.
Full textKinnings, Sarah L., Li Xie, Kingston H. Fung, Richard M. Jackson, Lei Xie, and Philip E. Bourne. "The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications." PLoS Computational Biology 6, no. 11 (November 4, 2010): e1000976. http://dx.doi.org/10.1371/journal.pcbi.1000976.
Full textWetzel, Carlie, Mitchell Lonneman, and Chun Wu. "Polypharmacological drug actions of recently FDA approved antibiotics." European Journal of Medicinal Chemistry 209 (January 2021): 112931. http://dx.doi.org/10.1016/j.ejmech.2020.112931.
Full textChand, Karam, Rajeshwari Rajeshwari, Emanuel Candeias, Sandra M. Cardoso, Sílvia Chaves, and M. Amélia Santos. "Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug." Metallomics 10, no. 10 (2018): 1460–75. http://dx.doi.org/10.1039/c8mt00143j.
Full textLiu, Wandong, Caiyun Hou, Jiaming Li, Xiaodong Ma, Yanchun Zhang, Mengqi Hu, and Yuanzheng Huang. "Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents." Journal of Enzyme Inhibition and Medicinal Chemistry 35, no. 1 (November 22, 2019): 187–98. http://dx.doi.org/10.1080/14756366.2019.1693703.
Full textReddy, A. Srinivas, Zhi Tan, and Shuxing Zhang. "Curation and Analysis of Multitargeting Agents for Polypharmacological Modeling." Journal of Chemical Information and Modeling 54, no. 9 (August 29, 2014): 2536–43. http://dx.doi.org/10.1021/ci500092j.
Full textPatel, Hitesh, Xavier Lucas, Igor Bendik, Stefan Günther, and Irmgard Merfort. "Target Fishing by Cross-Docking to Explain Polypharmacological Effects." ChemMedChem 10, no. 7 (June 1, 2015): 1209–17. http://dx.doi.org/10.1002/cmdc.201500123.
Full textSunduru, Naresh, Olli Salin, Åsa Gylfe, and Mikael Elofsson. "Design, synthesis and evaluation of novel polypharmacological antichlamydial agents." European Journal of Medicinal Chemistry 101 (August 2015): 595–603. http://dx.doi.org/10.1016/j.ejmech.2015.07.019.
Full textPapa, Alessandro, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, and Fabrizio Vincenzi. "Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition." Cells 11, no. 3 (January 29, 2022): 471. http://dx.doi.org/10.3390/cells11030471.
Full textLi, Bin, Min Xiong, and Hong-Yu Zhang. "Elucidating Polypharmacological Mechanisms of Polyphenols by Gene Module Profile Analysis." International Journal of Molecular Sciences 15, no. 7 (June 25, 2014): 11245–54. http://dx.doi.org/10.3390/ijms150711245.
Full textR. Sahrawat, Tammanna, and Prabhjeet Kaur Kaur. "Polypharmacological study of Ceritinib using a structure based in silico approach." Bionatura 4, no. 2 (May 15, 2019): 836–40. http://dx.doi.org/10.21931/rb/2019.04.02.3.
Full textTu, Gao, Tingting Fu, Fengyuan Yang, Jingyi Yang, Zhao Zhang, Xiaojun Yao, Weiwei Xue, and Feng Zhu. "Understanding the Polypharmacological Profiles of Triple Reuptake Inhibitors by Molecular Simulation." ACS Chemical Neuroscience 12, no. 11 (May 12, 2021): 2013–26. http://dx.doi.org/10.1021/acschemneuro.1c00127.
Full textNacher, Jose C., and Jean-Marc Schwartz. "Modularity in Protein Complex and Drug Interactions Reveals New Polypharmacological Properties." PLoS ONE 7, no. 1 (January 18, 2012): e30028. http://dx.doi.org/10.1371/journal.pone.0030028.
Full textVijayan, Ranjit, Bincy Baby, Priya Antony, Walaa Al Halabi, and Zahrah Al Homedi. "Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases." Drug Design, Development and Therapy Volume 10 (September 2016): 3109–23. http://dx.doi.org/10.2147/dddt.s118423.
Full textPark, Hwangseo, Hoi-Yun Jung, Shinmee Mah, Kewon Kim, and Sungwoo Hong. "Kinase and GPCR polypharmacological approach for the identification of efficient anticancer medicines." Organic & Biomolecular Chemistry 18, no. 41 (2020): 8402–13. http://dx.doi.org/10.1039/d0ob01917h.
Full textDutta, Devawati, Ranjita Das, Chhabinath Mandal, and Chitra Mandal. "Structure-Based Kinase Profiling To Understand the Polypharmacological Behavior of Therapeutic Molecules." Journal of Chemical Information and Modeling 58, no. 1 (December 15, 2017): 68–89. http://dx.doi.org/10.1021/acs.jcim.7b00227.
Full textKung, Mei-Lang, Pei-Ying Lin, Shih-Tsung Huang, Ming-Hong Tai, Shu-Ling Hsieh, Chih-Chung Wu, Bi-Wen Yeh, Wen-Jeng Wu, and Shuchen Hsieh. "Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines." ACS Applied Materials & Interfaces 11, no. 1 (December 19, 2018): 137–50. http://dx.doi.org/10.1021/acsami.8b14559.
Full textMoesker, A. "187 TREATMENT OF NEUROPATHIC PAIN IN CRPS TYPE-I ON A POLYPHARMACOLOGICAL BASIS." European Journal of Pain 11, S1 (June 2007): S81—S82. http://dx.doi.org/10.1016/j.ejpain.2007.03.202.
Full textKaplan, Andrew, Sebastian A. Andrei, Anna van Regteren Altena, Tristan Simas, Sara L. Banerjee, Nobuo Kato, Nicolas Bisson, Yusuke Higuchi, Christian Ottmann, and Alyson E. Fournier. "Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth." Cell Chemical Biology 27, no. 6 (June 2020): 657–67. http://dx.doi.org/10.1016/j.chembiol.2020.02.010.
Full textSharma, Charu, Juma M. Al Kaabi, Syed M. Nurulain, Sameer N. Goyal, Mohammad Amjad Kamal, and Shreesh Ojha. "Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise." Current Pharmaceutical Design 22, no. 21 (May 30, 2016): 3237–64. http://dx.doi.org/10.2174/1381612822666160311115226.
Full textChiu, Yi-Yuan, Chun-Yu Lin, Chih-Ta Lin, Kai-Cheng Hsu, Li-Zen Chang, and Jinn-Moon Yang. "Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets." BMC Genomics 13, Suppl 7 (2012): S21. http://dx.doi.org/10.1186/1471-2164-13-s7-s21.
Full textSalacz, Michael, Marc-Eric Halatsch, Georg Karpel-Massler, and Richard Kast. "RARE-09. MINIMALLY TOXIC MULTIMODAL AND POLYPHARMACOLOGICAL THERAPY IN TREATMENT OF DIFFUSE MIDLINE GLIOMA." Neuro-Oncology 19, suppl_6 (November 2017): vi213. http://dx.doi.org/10.1093/neuonc/nox168.862.
Full textGower, Carrie M., Jason R. Thomas, Edmund Harrington, Jason Murphy, Matthew E. K. Chang, Ivan Cornella-Taracido, Rishi K. Jain, Markus Schirle, and Dustin J. Maly. "Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity." ACS Chemical Biology 11, no. 1 (November 6, 2015): 121–31. http://dx.doi.org/10.1021/acschembio.5b00847.
Full textWang, Xia, Chenxu Pan, Jiayu Gong, Xiaofeng Liu, and Honglin Li. "Enhancing the Enrichment of Pharmacophore-Based Target Prediction for the Polypharmacological Profiles of Drugs." Journal of Chemical Information and Modeling 56, no. 6 (May 31, 2016): 1175–83. http://dx.doi.org/10.1021/acs.jcim.5b00690.
Full textBrunhofer, Gerda, Christian Studenik, Gerhard F. Ecker, and Thomas Erker. "Synthesis, spasmolytic activity and structure–activity relationship study of a series of polypharmacological thiobenzanilides." European Journal of Pharmaceutical Sciences 42, no. 1-2 (January 2011): 37–44. http://dx.doi.org/10.1016/j.ejps.2010.10.005.
Full textChicca, Andrea, Chiara Arena, Simone Bertini, Francesca Gado, Elena Ciaglia, Mario Abate, Maria Digiacomo, et al. "Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system." European Journal of Medicinal Chemistry 154 (June 2018): 155–71. http://dx.doi.org/10.1016/j.ejmech.2018.05.019.
Full textMaccallini, Cristina, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, and Rosa Amoroso. "HDAC Inhibitors for the Therapy of Triple Negative Breast Cancer." Pharmaceuticals 15, no. 6 (May 26, 2022): 667. http://dx.doi.org/10.3390/ph15060667.
Full textJanardhan, S., L. John, M. Prasanthi, V. Poroikov, and G. Narahari Sastry. "A QSAR and molecular modelling study towards new lead finding: polypharmacological approach to Mycobacterium tuberculosis." SAR and QSAR in Environmental Research 28, no. 10 (October 3, 2017): 815–32. http://dx.doi.org/10.1080/1062936x.2017.1398782.
Full textDurrant, Jacob D., Rommie E. Amaro, Lei Xie, Michael D. Urbaniak, Michael A. J. Ferguson, Antti Haapalainen, Zhijun Chen, et al. "A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology." PLoS Computational Biology 6, no. 1 (January 22, 2010): e1000648. http://dx.doi.org/10.1371/journal.pcbi.1000648.
Full textWei, Tzu-Tang, Yi-Ting Lin, Ruo-Yu Tseng, Chia-Tung Shun, Yu-Chin Lin, Ming-Shiang Wu, Jim-Min Fang, and Ching-Chow Chen. "Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor." Clinical Cancer Research 22, no. 16 (August 14, 2016): 4158–69. http://dx.doi.org/10.1158/1078-0432.ccr-15-2379.
Full textTao, Qiangqiang, Fang Fang, Jiaming Li, Yong Wang, Can Zhao, Jingtai Liang, Xiaodong Ma, and Hao Wang. "A conjugated mTOR/MEK bifunctional inhibitor as potential polypharmacological anticancer agent: the prototype compound discovery." Medicinal Chemistry Research 29, no. 3 (January 13, 2020): 519–27. http://dx.doi.org/10.1007/s00044-020-02502-x.
Full textZHENG, CHUN-SONG, YIN-SHENG WU, HONG-JUAN BAO, XIAO-JIE XU, XING-QIANG CHEN, HONG-ZHI YE, GUANG-WEN WU, et al. "Understanding the polypharmacological anticancer effects of Xiao Chai Hu Tang via a computational pharmacological model." Experimental and Therapeutic Medicine 7, no. 6 (April 2, 2014): 1777–83. http://dx.doi.org/10.3892/etm.2014.1660.
Full textReyes-Parada, Miguel, and Patricio Iturriaga-Vasquez. "The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors." Expert Opinion on Drug Discovery 11, no. 10 (August 30, 2016): 969–81. http://dx.doi.org/10.1080/17460441.2016.1227317.
Full textKiilerich, K., N. Speth, J. Lorenz, A. Casado-Sainz, V. Shalgunov, D. Lange, M. Xiong, et al. "P.228 The polypharmacological profile of psilocybin and potential behavioural effects of very low doses." European Neuropsychopharmacology 29 (December 2019): S175—S176. http://dx.doi.org/10.1016/j.euroneuro.2019.09.271.
Full textHemmati, Shiva, and Haniyeh Rasekhi Kazerooni. "Polypharmacological Cell-Penetrating Peptides from Venomous Marine Animals Based on Immunomodulating, Antimicrobial, and Anticancer Properties." Marine Drugs 20, no. 12 (December 4, 2022): 763. http://dx.doi.org/10.3390/md20120763.
Full textKumari, Shikha, Chandra Bhushan Mishra, and Manisha Tiwari. "Polypharmacological Drugs in the Treatment of Epilepsy: The Comprehensive Review of Marketed and New Emerging Molecules." Current Pharmaceutical Design 22, no. 21 (May 30, 2016): 3212–25. http://dx.doi.org/10.2174/1381612822666160226144200.
Full textAllen, B., S. Mehta, N. Ayad, and S. Schurer. "DD-01 * LIGAND- AND STRUCTURE-BASED VIRTUAL SCREENING TO DISCOVER POLYPHARMACOLOGICAL DUAL EGFR AND BRD4 INHIBITORS." Neuro-Oncology 16, suppl 5 (November 1, 2014): v60. http://dx.doi.org/10.1093/neuonc/nou246.1.
Full textTao, Li, Min Xu, Xiaojun Dai, Tengyang Ni, Dan Li, Feng Jin, Haibo Wang, et al. "Polypharmacological Profiles Underlying the Antitumor Property ofSalvia miltiorrhizaRoot (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps." Oxidative Medicine and Cellular Longevity 2018 (August 19, 2018): 1–16. http://dx.doi.org/10.1155/2018/4908328.
Full textMok, Simon Wing-Fai, Vincent Kam-Wai Wong, Hang-Hong Lo, Ivo Ricardo de Seabra Rodrigues Dias, Elaine Lai-Han Leung, Betty Yuen-Kwan Law, and Liang Liu. "Natural products-based polypharmacological modulation of the peripheral immune system for the treatment of neuropsychiatric disorders." Pharmacology & Therapeutics 208 (April 2020): 107480. http://dx.doi.org/10.1016/j.pharmthera.2020.107480.
Full textCheng, Feixiong, Weihua Li, Zengrui Wu, Xichuan Wang, Chen Zhang, Jie Li, Guixia Liu, and Yun Tang. "Prediction of Polypharmacological Profiles of Drugs by the Integration of Chemical, Side Effect, and Therapeutic Space." Journal of Chemical Information and Modeling 53, no. 4 (April 8, 2013): 753–62. http://dx.doi.org/10.1021/ci400010x.
Full textAntony, Priya, Bincy Baby, Zahrah Al Homedi, Walaa Al Halabi, Amanat Ali, and Ranjit Vijayan. "Polypharmacological potential of natural compounds against prostate cancer explored using molecular docking and molecular dynamics simulations." International Journal of Computational Biology and Drug Design 13, no. 2 (2020): 181. http://dx.doi.org/10.1504/ijcbdd.2020.10029439.
Full textAntony, Priya, Bincy Baby, Zahrah Al Homedi, Walaa Al Halabi, Amanat Ali, and Ranjit Vijayan. "Polypharmacological potential of natural compounds against prostate cancer explored using molecular docking and molecular dynamics simulations." International Journal of Computational Biology and Drug Design 13, no. 2 (2020): 181. http://dx.doi.org/10.1504/ijcbdd.2020.107314.
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