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Journal articles on the topic 'Polymeric drug delivery systems'

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Published: 4 June 2021
Last updated: 11 March 2023

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1

Román, Julio San, Alberto Gallardo, and Belén Levenfeld. "Polymeric drug delivery systems." Advanced Materials 7, no. 2 (February 1995): 203–8. http://dx.doi.org/10.1002/adma.19950070223.

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2

Davies, M. "Polymeric Drugs and Drug Delivery Systems." Biomaterials 14, no. 3 (January 1993): 239. http://dx.doi.org/10.1016/0142-9612(93)90033-x.

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3

Kennedy, John F., and Giampiero Pagliuca. "Polymeric Drugs and Drug Delivery Systems." Carbohydrate Polymers 18, no. 4 (January 1992): 311–12. http://dx.doi.org/10.1016/0144-8617(92)90098-b.

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4

Demchuk, Zoriana, Mariya Savka, Andriy Voronov, Olga Budishevska, Volodymyr Donchak, and Stanislav Voronov. "Amphiphilic Polymers Containing Cholesterol for Drug Delivery Systems." Chemistry & Chemical Technology 10, no. 4s (December 25, 2016): 561–70. http://dx.doi.org/10.23939/chcht10.04si.561.

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The interaction of binary copolymers poly(maleic anhydride-co-poly(ethylene glycol) methyl ether methacrylate) with cholesterol results in formation of cholesterol containing polymers, which contain from 4.6 to 46.0 mol % monocholesteryl maleic links. Their structure was confirmed using functional analysis and IR spectroscopy. Acidic and anhydride links of these copolymers form polymeric salts if react with alkali. These salts are surfactants which in aqueous medium form a hierarchy micelles and micellar aggregates depending on the copolymer concentration. Using conductometry it was found that preferably monomolecular micelles are formed in dilute solutions, and micellar aggregates begin to form at higher concentrations. In aqueous media polymeric salts are able to solubilize such lipophilic substances as Sudan III dye and anticancer drug curcumin. Efficiency of solubilization towards Sudan III grows if the content of monocholesteryl maleic fragment in surfactant increases.
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5

D'Emanuele, Antony. "Responsive Polymeric Drug Delivery Systems." Clinical Pharmacokinetics 31, no. 4 (October 1996): 241–45. http://dx.doi.org/10.2165/00003088-199631040-00001.

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6

Jeong, Seo Young, and Sung Wan Kim. "Biodegradable polymeric drug delivery systems." Archives of Pharmacal Research 9, no. 2 (June 1986): 63–73. http://dx.doi.org/10.1007/bf02857213.

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7

Rawat, S., S. Bisht, and P. Kothiyal. "PULSATILE DRUG DELIVERY A PROGRAMMED POLYMERIC DEVICE." INDIAN DRUGS 50, no. 05 (May 28, 2013): 5–22. http://dx.doi.org/10.53879/id.50.05.p0005.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place, at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. The use of pulsatile release of the drugs is desirable where constant drug release is not desired. These systems are designed according to the circadian rhythm of the body. According to Latin literature circa means about and Diem means day. This could be advantageous for many drugs or therapies including asthma, peptic ulcer & arthritis etc. To correlate with our biological needs, “precisely timed drug delivery,” which could be accomplished with “programmable dosage forms,” is desirable. Precisely timed drug delivery may maximize therapeutic efficacy, minimize dose frequency, and may reduce toxicity. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical device.
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8

Rawat, S., S. Bisht, and P. Kothiyal. "PULSATILE DRUG DELIVERY A PROGRAMMED POLYMERIC DEVICE." INDIAN DRUGS 50, no. 05 (May 28, 2013): 5–22. http://dx.doi.org/10.53879/id.50.05.p0005.

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Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place, at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. The use of pulsatile release of the drugs is desirable where constant drug release is not desired. These systems are designed according to the circadian rhythm of the body. According to Latin literature circa means about and Diem means day. This could be advantageous for many drugs or therapies including asthma, peptic ulcer & arthritis etc. To correlate with our biological needs, “precisely timed drug delivery,” which could be accomplished with “programmable dosage forms,” is desirable. Precisely timed drug delivery may maximize therapeutic efficacy, minimize dose frequency, and may reduce toxicity. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical device.
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9

Madan, M., A. Bajaj, S. Lewis, N. Udupa, and JA Baig. "In situforming polymeric drug delivery systems." Indian Journal of Pharmaceutical Sciences 71, no. 3 (2009): 242. http://dx.doi.org/10.4103/0250-474x.56015.

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10

Yoon, Hee-Jae, and Woo-Dong Jang. "Polymeric supramolecular systems for drug delivery." J. Mater. Chem. 20, no. 2 (2010): 211–22. http://dx.doi.org/10.1039/b910948j.

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11

Thatte, Suhas, Kapil Datar, and Raphael M. Ottenbrite. "Perspectives On: Polymeric Drugs and Drug Delivery Systems." Journal of Bioactive and Compatible Polymers 20, no. 6 (November 2005): 585–601. http://dx.doi.org/10.1177/0883911505059549.

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12

Langer, Robert. "Drug Delivery Systems." MRS Bulletin 16, no. 9 (September 1991): 47–49. http://dx.doi.org/10.1557/s0883769400056050.

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For many years, drug delivery systems were composed of simple pills, eyedrops, ointments, or intravenous solutions. Recently, materials have begun to play a major role in improving drug delivery. Drugs are now chemically attached to polymers, entrapped in small vesicles that are injected into the bloodstream, or put in pumps or polymeric materials that are placed in the body. These new materials-based systems are beginning to change the way drugs can be administered and, in so doing, have improved human health. This article provides a brief review of the major classes of drug delivery systems; a recent paper discusses these issues in detail.Chemically attaching a drug to a polymer may alter such properties as its distribution in the body, rate of appearance in certain tissues, solubility, or antigenicity. For example, drugs have been linked to soluble macromolecules such as proteins, polysaccharides, or synthetic polymers via degradable linkages. This alters the drug's size and other properties, resulting in a different bodily drug distribution pattern. One example involves coupling the antitumor agent neocarzinostatin to styrene-maleic acid copolymers. When this complex was injected intra-arterially in patients with liver cancer, tumor size decreased significantly. In animals, the antitumor agent, doxorubicin, bound to N(2-hydroxypropyl) methacrylamide copolymers reduced toxicity. The plasma half-life and the drug levels in the tumor increased while the concentrations in the rest of the body decreased.
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13

Jain, Shikha, Vikas Jain, and S. C. Mahajan. "Lipid Based Vesicular Drug Delivery Systems." Advances in Pharmaceutics 2014 (September 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/574673.

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Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.
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14

Berillo, Dmitriy, Adilkhan Yeskendir, Zharylkasyn Zharkinbekov, Kamila Raziyeva, and Arman Saparov. "Peptide-Based Drug Delivery Systems." Medicina 57, no. 11 (November 5, 2021): 1209. http://dx.doi.org/10.3390/medicina57111209.

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Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide–drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.
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15

Ahmad, Zaheer, Afzal Shah, Muhammad Siddiq, and Heinz-Bernhard Kraatz. "Polymeric micelles as drug delivery vehicles." RSC Adv. 4, no. 33 (2014): 17028–38. http://dx.doi.org/10.1039/c3ra47370h.

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16

Nair, Praful R. "Delivering Combination Chemotherapies and Targeting Oncogenic Pathways via Polymeric Drug Delivery Systems." Polymers 11, no. 4 (April 5, 2019): 630. http://dx.doi.org/10.3390/polym11040630.

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The side-effects associated with chemotherapy necessitates better delivery of chemotherapeutics to the tumor. Nanoparticles can load higher amounts of drug and improve delivery to tumors, increasing the efficacy of treatment. Polymeric nanoparticles, in particular, have been used extensively for chemotherapeutic delivery. This review describes the efforts made to deliver combination chemotherapies and inhibit oncogenic pathways using polymeric drug delivery systems. Combinations of chemotherapeutics with other drugs or small interfering RNA (siRNA) combinations have been summarized. Special attention is given to the delivery of drug combinations that involve either paclitaxel or doxorubicin, two popular chemotherapeutics in clinic. Attempts to inhibit specific pathways for oncotherapy have also been described. These include inhibition of oncogenic pathways (including those involving HER2, EGFR, MAPK, PI3K/Akt, STAT3, and HIF-1α), augmentation of apoptosis by inhibiting anti-apoptosis proteins (Bcl-2, Bcl-xL, and survivin), and targeting dysregulated pathways such as Wnt/β-catenin and Hedgehog.
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17

EL FRAY, MIROSLAWA, and JOANNA GAJOWY. "Polymeric self-assemblies as drug delivery systems." Polimery 57, no. 4 (April 2012): 257–65. http://dx.doi.org/10.14314/polimery.2012.257.

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18

Anghel, Sanziana, Muhammad Arif Mahmood, Consuela Elena Matei, and Anita Ioana Visan. "Polymeric Coatings for Drug Delivery by Medical Devices." Journal of Nanotechnology in Diagnosis and Treatment 7 (October 31, 2021): 33–48. http://dx.doi.org/10.12974/2311-8792.2021.07.4.

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An analysis of the current landscape of therapeutics and delivery methods was conducted, aiming the field of drug delivery systems. Drug delivery biodistribution characteristics should be systematically understood, in order to maximize the function of these delivery systems. As a result, this review covers a history of the drug delivery systems, as well as the basic terminology associated with them, with a focus on the usage of polymers in the drug administration systems (particularly in form of coatings) and their application. New trends in nanomaterials-based drug delivery systems, primarily for cancer treatment, were presented, involving a technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. There is a justified need to investigate drug delivery systems in form of thin films because, in comparation to bulk drug delivery system, which have a long and comprehensive history, there is still insufficient and fragmented understanding about the delivery of thin polymeric films, with research limited in general to very specific cases. Our efforts have been concentrated on these specifically polymeric drug delivery systems in the form of coatings. Understanding the dynamic changes that occur in a biodegradable polymeric thin film can aid in the prediction of the future performance of synthesized films designed to be used as implantable medical devices. Extensive research is required to continuously develop new therapeutic systems in order to achieve an optimal concentration of a specific drug at its site of action for an appropriate duration.
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19

Nakayama, Masamichi. "Thermoresponsive polymeric materials for drug delivery systems." Drug Delivery System 23, no. 6 (2008): 627–36. http://dx.doi.org/10.2745/dds.23.627.

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20

Borandeh, Sedigheh, Bas van Bochove, Arun Teotia, and Jukka Seppälä. "Polymeric drug delivery systems by additive manufacturing." Advanced Drug Delivery Reviews 173 (June 2021): 349–73. http://dx.doi.org/10.1016/j.addr.2021.03.022.

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21

Gong, C., T. Qi, X. Wei, Y. Qu, Q. Wu, F. Luo, and Z. Qian. "Thermosensitive Polymeric Hydrogels As Drug Delivery Systems." Current Medicinal Chemistry 20, no. 1 (December 1, 2012): 79–94. http://dx.doi.org/10.2174/0929867311302010009.

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22

Smyth, Hugh D. C. "A Review of: “Polymeric Drug Delivery Systems”." Drug Development and Industrial Pharmacy 32, no. 9 (January 2006): 1111. http://dx.doi.org/10.1080/03639040600599913.

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23

Sershen, S., and J. West. "Implantable, polymeric systems for modulated drug delivery." Advanced Drug Delivery Reviews 54, no. 9 (November 2002): 1225–35. http://dx.doi.org/10.1016/s0169-409x(02)00090-x.

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24

Kumari, Avnesh, Sudesh Kumar Yadav, and Subhash C. Yadav. "Biodegradable polymeric nanoparticles based drug delivery systems." Colloids and Surfaces B: Biointerfaces 75, no. 1 (January 2010): 1–18. http://dx.doi.org/10.1016/j.colsurfb.2009.09.001.

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25

Majumder, Nairrita, Nandita G Das, and Sudip K. Das. "Polymeric micelles for anticancer drug delivery." Therapeutic Delivery 11, no. 10 (October 2020): 613–35. http://dx.doi.org/10.4155/tde-2020-0008.

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Polymeric micelles have gained interest as novel drug delivery systems for the treatment and diagnosis of cancer, as they offer several advantages over conventional drug therapies. This includes drug targeting to tumor tissue, in vivo biocompatibility and biodegradability, prolonged circulation time, enhanced accumulation, retention of the drug loaded micelle in the tumor and decreased side effects. This article provides an overview on the current state of micellar formulations as nanocarriers for anticancer drugs and their effectiveness in cancer therapeutics, including their clinical status. The type of copolymers used, their physicochemical properties and characterization as well as recent developments in the design of functional polymeric micelles are highlighted. The article also presents the design and outcomes of various types of stimuli-responsive polymeric micelles.
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26

Heggannavar, Geetha B., Divya Achari, Cristiana Fernandes, Geoffrey R. Mitchell, Pedro Morouço, and Mahadevappa Y. Kariduraganavar. "Smart Polymers in Drug Delivery Applications." Applied Mechanics and Materials 890 (April 2019): 324–39. http://dx.doi.org/10.4028/www.scientific.net/amm.890.324.

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The most important components of living cells such as carbohydrates, proteins and nucleic acids are the polymeric molecules. Nature utilizes polymers both as constructive elements and as a part of the complicated cell machinery of living things. The rapid advancement in biomedical research has led to many creative applications for biocompatible polymers. With the development of newer and more potent drugs, a parallel expansion in more sophisticated drug delivery systems becomes mandatory. Smart polymeric drug-delivery systems have the ability to respond to environmental changes and consequently, alter their properties reversibly enabling an efficient and safe drug delivery. This review comprehensively discusses various aspects of these polymers classified in different categories as per the type of stimulus.
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27

AbdElhamid, Ahmed S., Dina G. Zayed, Lamia Heikal, Sherine N. Khattab, Omar Y. Mady, Sanaa A. El-Gizawy, and Ahmed O. Elzoghby. "Recent advances in polymer shell oily-core nanocapsules for drug-delivery applications." Nanomedicine 16, no. 18 (August 2021): 1613–25. http://dx.doi.org/10.2217/nnm-2021-0037.

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Polymeric nanocapsules are vesicular drug-delivery systems composed of an inner oily reservoir surrounded by polymeric membranes. Nanocapsules have various advantages over other nanovesicular systems such as providing controlled drug release properties. We discuss the recent advances in polymeric shell oily-core nanocapsules, illustrating the different types of polymers used and their implementation. Nanocapsules can be utilized for many purposes, especially encapsulation of highly lipophilic drugs. They have been shown to have variable applications, especially in cancer therapy, due to the ability of the polymeric shell to direct the loaded drugs to their target sites, as well as their high internalization efficacy. Those productive applications guaranteed their high potential as drug-delivery systems. However, their clinical development is still in an early stage.
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28

Begines, Belén, Tamara Ortiz, María Pérez-Aranda, Guillermo Martínez, Manuel Merinero, Federico Argüelles-Arias, and Ana Alcudia. "Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects." Nanomaterials 10, no. 7 (July 19, 2020): 1403. http://dx.doi.org/10.3390/nano10071403.

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The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.
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29

Yahya, Ibtihag, Razan Atif, Lina Ahmed, Tahleel Salah Eldeen, Akram Omara, and Megdi Eltayeb. "Polymeric Nanoparticles as Drug Delivery Systems for Controlled Release." Advanced Science, Engineering and Medicine 12, no. 2 (February 1, 2020): 263–70. http://dx.doi.org/10.1166/asem.2020.2495.

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This study focuses on providing a comparative mathematical analysis of drug release from polymeric nanoparticle with different structures to allow in silico prediction of the appropriate and optimal model that applies to the whole drug release and not limited to a part of the process. The drug release data from nanoparticles have been applied using MATLAB software to apply mathematical models such as Zero-order, First-order, Higuchi, Hixson–Crowell, Korsmeyer-Peppas models besides a proposed model called Tanh function. This study results highlight the usefulness of mathematical models, key findings emerge that the Tanh model and First-order model gave the best fits of the parameters data as both model's plots showed high linear correlation (R2 = 0.9781, 0.9448) respectively. Finally, this study concludes that both proposed Tanh function and First-order model shows better performance, giving good results and can be successfully used to characterize drug and applied for prolonged drugs release.
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30

Avramović, Nataša, Boris Mandić, Ana Savić-Radojević, and Tatjana Simić. "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy." Pharmaceutics 12, no. 4 (March 25, 2020): 298. http://dx.doi.org/10.3390/pharmaceutics12040298.

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Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
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31

Kotta, Sabna, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, and Kamal YT. "Progress in Polymeric Micelles for Drug Delivery Applications." Pharmaceutics 14, no. 8 (August 5, 2022): 1636. http://dx.doi.org/10.3390/pharmaceutics14081636.

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Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core–shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent advances and understandings of PMs with a focus on the latest drug delivery applications. The types, methods of preparation and characterization of PMs are described along with their applications in oral, parenteral, transdermal, intranasal and other drug delivery systems. The applications of PMs for tumor-targeted delivery have been provided special attention. The safety, quality and stability of PMs in relation to drug delivery are also provided. In addition, advanced polymeric systems and special PMs are also reviewed. The in vitro and in vivo stability assessment of PMs and recent understandings in this area are provided. The patented PMs and clinical trials on PMs for drug delivery applications are considered indicators of their tremendous future applications. Overall, PMs can help overcome many unresolved issues in drug delivery.
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32

Sizochenko, Natalia, and Jerzy Leszczynski. "Drug-Nanoparticle Composites." Journal of Nanotoxicology and Nanomedicine 2, no. 1 (January 2017): 1–10. http://dx.doi.org/10.4018/jnn.2017010101.

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Polymeric nanoparticles represent attractive targets for the controlled delivery of therapeutic drugs. Drug-nanoparticle conjugates are convenient targets to enhance solubility and membrane permeability of drugs, prolong circulation time and minimize non-specific uptake. The behavior of drugs-loaded nanoparticles is governed by various factors. Understanding of these effects is very important for design of drug-nanoparticle systems, that could be suitable for treating the particular diseases. The aim of the current study is a complementary molecular docking followed by quantitative structure-activity relationships modeling for drugs payload on polymeric nanoparticles. Twenty-one approved drugs were considered. Docking of drugs was performed towards a simplified polymeric surface. Binding energies agreed well with the observed mass loading. Quantitative structure-activity relationships model supported this data. Effects of electronegativity and hydrophobicity were discussed. Developed model may contribute to the development of other useful nano-sized polymeric drug carriers to deliver a spectrum of therapeutic and imaging agents for medical purposes.
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33

Dumitriu, Severian, Marcel Popa, and Maria Dumitriu. "Review : Polymeric Biomaterials As Enzyme and Drug Carriers* Part III: Polymeric Drugs and Drug Delivery Systems." Journal of Bioactive and Compatible Polymers 4, no. 1 (January 1989): 57–73. http://dx.doi.org/10.1177/088391158900400107.

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34

Malik, Rafi, Tarun Garg, Amit K. Goyal, and Goutam Rath. "Polymeric nanofibers: targeted gastro-retentive drug delivery systems." Journal of Drug Targeting 23, no. 2 (September 30, 2014): 109–24. http://dx.doi.org/10.3109/1061186x.2014.965715.

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35

Alvarez-Lorenzo, Carmen, and Angel Concheiro. "Intelligent Drug Delivery Systems: Polymeric Micelles and Hydrogels." Mini-Reviews in Medicinal Chemistry 8, no. 11 (October 1, 2008): 1065–74. http://dx.doi.org/10.2174/138955708785909952.

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36

Sabbagh, Farzaneh, and Beom Soo Kim. "Recent advances in polymeric transdermal drug delivery systems." Journal of Controlled Release 341 (January 2022): 132–46. http://dx.doi.org/10.1016/j.jconrel.2021.11.025.

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37

Siepmann, J. "Mathematical modeling of bioerodible, polymeric drug delivery systems." Advanced Drug Delivery Reviews 48, no. 2-3 (June 11, 2001): 229–47. http://dx.doi.org/10.1016/s0169-409x(01)00116-8.

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38

De Souza, Raquel, Payam Zahedi, Christine J. Allen, and Micheline Piquette-Miller. "Polymeric drug delivery systems for localized cancer chemotherapy." Drug Delivery 17, no. 6 (April 30, 2010): 365–75. http://dx.doi.org/10.3109/10717541003762854.

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39

Hashida, Mitsuru, and Yoshinobu Takakura. "Pharmacokinetics in design of polymeric drug delivery systems." Journal of Controlled Release 31, no. 2 (September 1994): 163–71. http://dx.doi.org/10.1016/0168-3659(94)00025-5.

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40

Ahlawat, Jyoti, Gabriela Henriquez, and Mahesh Narayan. "Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles." Molecules 23, no. 9 (August 27, 2018): 2157. http://dx.doi.org/10.3390/molecules23092157.

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While pharmaceutical drugs have revolutionized human life, there are several features that limit their full potential. This review draws attention to some of the obstacles currently facing the use of chemotherapeutic drugs including low solubility, poor bioavailability and high drug dose. Overcoming these issues will further enhance the applicability and potential of current drugs. An emerging technology that is geared towards improving overall therapeutic efficiency resides in drug delivery systems including the use of polymeric nanoparticles which have found widespread use in cancer therapeutics. These polymeric nanoparticles can provide targeted drug delivery, increase the circulation time in the body, reduce the therapeutic indices with minimal side-effects, and accumulate in cells without activating the mononuclear phagocyte system (MPS). Given the inroads made in the field of nanodelivery systems for pharmaceutical applications, it is of interest to review and emphasize the importance of Polymeric nanocarrier system for drug delivery in chemotherapy.
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41

Mhlwatika, Zandile, and Blessing Aderibigbe. "Polymeric Nanocarriers for the Delivery of Antimalarials." Molecules 23, no. 10 (October 2, 2018): 2527. http://dx.doi.org/10.3390/molecules23102527.

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Malaria is an infectious disease caused by a protozoan parasite which is transmitted by female Anopheles mosquitoes around tropical and sub-tropical regions. Half of the world’s population is at risk of being infected by malaria. This mainly includes children, pregnant women and people living with chronic diseases. The main factor that has contributed to the spread of this disease is the increase in the number of drug-resistant parasites. To overcome drug resistance, researchers have developed drug delivery systems from biodegradable polymers for the loading of antimalarials. The drug delivery systems were characterized by distinct features such as good biocompatibility, high percentage drug encapsulation, reduced drug toxicity and targeted drug delivery. In this review article, we highlight the various types of drug delivery systems developed from polymeric nanocarriers used for the delivery of antimalarials.
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42

Li, Linying, Chanhwa Lee, Daniela F. Cruz, Sai Archana Krovi, Michael G. Hudgens, Mackenzie L. Cottrell, and Leah M. Johnson. "Reservoir-Style Polymeric Drug Delivery Systems: Empirical and Predictive Models for Implant Design." Pharmaceuticals 15, no. 10 (October 3, 2022): 1226. http://dx.doi.org/10.3390/ph15101226.

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Controlled drug delivery systems can provide sustained release profiles, favorable pharmacokinetics, and improved patient adherence. Here, a reservoir-style implant comprising a biodegradable polymer, poly(ε-caprolactone) (PCL), was developed to deliver drugs subcutaneously. This work addresses a key challenge when designing these implantable drug delivery systems, namely the accurate prediction of drug release profiles when using different formulations or form factors of the implant. The ability to model and predict the release behavior of drugs from an implant based on their physicochemical properties enables rational design and optimization without extensive and laborious in vitro testing. By leveraging experimental observations, we propose a mathematical model that predicts the empirical parameters describing the drug diffusion and partitioning processes based on the physicochemical properties of the drug. We demonstrate that the model enables an adequate fit predicting empirical parameters close to experimental values for various drugs. The model was further used to predict the release performance of new drug formulations from the implant, which aligned with experimental results for implants exhibiting zero-order release kinetics. Thus, the proposed empirical models provide useful tools to inform the implant design to achieve a target release profile.
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43

Rao, Monica RP, Ashwini Sonawane, Sharwari Sapate, and Kshitija Abhang. "Exploring Recent Advances in Nanotherapeutics." Journal of Drug Delivery and Therapeutics 10, no. 5-s (October 15, 2020): 273–80. http://dx.doi.org/10.22270/jddt.v10i5-s.4484.

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Nanotechnology is a rapidly expanding field, encompassing the development of materials in a size range of 5-200 nanometers (nm). The applications of nanotechnology to drug delivery opened the floodgates to create novel therapeutics and diagnostics which have changed the landscape of pharmaceutical and biotechnological industries. Advances in nanotechnology are being utilized in medicine for therapeutic drug delivery and treatment of various diseases and disorders. The biodegradable nanoparticle/nanocarriers, in which drug is dissolved and entrapped are specially designed to absorb the drug and to protect it against chemical and enzymatic degradation. The important role to design these nanostructures as a delivery system is to release pharmacologically active molecules for site-specific action with an accurate dose. In recent times, several biodegradable polymeric nanostructures have been developed with an innate capacity to target specific organs/tissue to deliver the drug. Nanoparticulate drug delivery systems use polymers or lipids as carriers for drugs. Newer polymers engineered to achieve temporal and spatial drug delivery form the mainstay of these systems. In nanotechnology, being tiny molecules of immunotherapeutic have many advantages over biological drugs regarding complexity, tissue penetration, manufacturing cost, stability and shelf life, which is one of dominating therapy in the current research field. The present review gives details about the recent developments of nanostructure drug delivery systems and their applications. Keywords: liposomes, polymeric micelles, gold nanoparticles, superparamagnetic nanoparticles, solid lipid nanoparticles, aptamers, quantum dots.
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44

Misiak, Paweł, Karolina H. Markiewicz, Dawid Szymczuk, and Agnieszka Z. Wilczewska. "Polymeric Drug Delivery Systems Bearing Cholesterol Moieties: A Review." Polymers 12, no. 11 (November 6, 2020): 2620. http://dx.doi.org/10.3390/polym12112620.

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This review aims to provide an overview of polymers comprising cholesterol moiety/ies designed to be used in drug delivery. Over the last two decades, there have been many papers published in this field, which are summarized in this review. The primary focus of this article is on the methods of synthesis of polymers bearing cholesterol in the main chain or as side chains. The data related to the composition, molecular weight, and molecular weight distribution of polymers are presented. Moreover, other aspects, such as forms of carriers, types of encapsulated drugs, encapsulation efficiency and capacity, are also included.
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45

Harwansh, Ranjit K., Rohitas Deshmukh, Md Abul Barkat, and Md Akhlaquer Rahman. "Bioinspired Polymeric-based Core-shell Smart Nano-systems." Pharmaceutical Nanotechnology 7, no. 3 (August 6, 2019): 181–205. http://dx.doi.org/10.2174/2211738507666190429104550.

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Smart nanosystems (SNs) have the potential to revolutionize drug delivery. Conventional drug delivery systems have poor drug-loading, early burst release, limited therapeutic effects, etc. Thus, to overcome these problems, researchers have taken advantage of the host-guest interactions as bioinspired nanosystems which can deliver nanocarriers more efficiently with the maximum drug loading capacity and improved therapeutic efficacy as well as bioavailability. SNs employ nanomaterials to form cage molecules by entrapping new nanocarriers called smart nanosystems in their cargo and design. The activities of SNs are based on responsive materials that interact with the stimuli either by changing their properties or conformational structures. The aptitude of living systems to respond to stimuli and process information has encouraged researchers to build up integrated nanosystems exhibiting similar function and therapeutic response. Various smart materials, including polymers, have been exhaustively employed in fabricating different stimuli-responsive nanosystems which can deliver bioactive molecules to a specific site for a certain period with minimal side effects. SNs have been widely explored to deliver diverse kinds of therapeutic agents ranging from bioactive compounds, genes, and biopharmaceuticals like proteins and peptides, to diagnostic imaging agents for biomedical applications. Nanotechnology-based different nanosystems are promising for health care issues. The advancement of SNs with physical science and engineering technology in synthesizing nanostructures and their physicochemical characterization should be exploited in medicine and healthcare for reducing mortality rate, morbidity, disease prevalence and general societal burden.
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46

AHMED, Sana, and Kazuaki MATSUMURA. "Freezing Assisted Protein Delivery by Using Polymeric Cryoprotectant." MRS Proceedings 1622 (2014): 123–27. http://dx.doi.org/10.1557/opl.2014.39.

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ABSTRACTA number of drug carrier systems such as liposomes, polymeric-nanoparticles, microparticles, polymeric micelles have been investigated for intracellular delivery. Among these liposomes are the potential drug vehicles for efficient cytosolic delivery. They have an adhesive property for cell membrane to encapsulate the drug or protein effectively and showing the enhanced absorption rate. One of the problems could be the difficulty of incorporation of the drug or protein into cell. Therefore many studies of the drug carriers have been developed to enhance the intracellular delivery of materials. Here we propose the novel method to improve the intracellular uptaking by using freeze concentration. Solutes are excluded from ice crystallization and concentrated in the remaining solution during freezing by freezing concentration. We have reported that polymeric cryoprotectant which is carboxylated poly-L-lysine was adsorbed on to the cell membrane during freezing and caused effective freeze concentration. In this study we investigated that delivery of protein effectively taking place by liposome as a carrier agent. It was successfully delivered protein to L929 cells via freeze concentration using polymeric cryoprotectant as a novel drug delivery.
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Chen, Feng, Yang Li, Xiongjie Lin, Huayu Qiu, and Shouchun Yin. "Polymeric Systems Containing Supramolecular Coordination Complexes for Drug Delivery." Polymers 13, no. 3 (January 25, 2021): 370. http://dx.doi.org/10.3390/polym13030370.

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Cancer has become a common disease that seriously endangers human health and life. Up to now, the essential treatment method has been drug therapy, and drug delivery plays an important role in cancer therapy. To improve the efficiency of drug therapy, researchers are committed to improving drug delivery methods to enhance drug pharmacokinetics and cancer accumulation. Supramolecular coordination complexes (SCCs) with well-defined shapes and sizes are formed through the coordination between diverse functional organic ligands and metal ions, and they have emerged as potential components in drug delivery and cancer therapy. In particular, micelles or vesicles with the required biocompatibility and stability are synthesized using SCC-containing polymeric systems to develop novel carriers for drug delivery that possess combined properties and extended system tunability. In this study, the research status of SCC-containing polymeric systems as drug carriers and adjuvants for cancer treatment is reviewed, and a special focus is given to their design and preparation.
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48

Villarreal-Gómez, Luis Jesús, Aracely Serrano-Medina, Erick José Torres-Martínez, Graciela Lizeth Perez-González, and José Manuel Cornejo-Bravo. "Polymeric advanced delivery systems for antineoplasic drugs: doxorubicin and 5-fluorouracil." e-Polymers 18, no. 4 (July 26, 2018): 359–72. http://dx.doi.org/10.1515/epoly-2017-0202.

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AbstractConventional pharmaceuticals generally display the inability to transport active ingredients directly to specific regions of the body, amongst some of their main limitations. The distribution of the drugs in the circulatory system may lead to undesired toxicity, and therefore, adverse reactions. To address this situation, a selective transport of drugs is required, that is, releasing drugs specifically to the site of action in appropriate concentrations and in the right time. To achieve this goal, it is necessary to develop delivery systems that respond to several features, such as low toxicity, optimum properties for the transport and release of the drug, as well as a long half-life in the body. This feature paper critically provides an overview of different strategies of controlled drug release for two model antineoplasic drugs, i.e. doxorubicin (DOX) and 5-fluorouracil (5-FU). Any of the presented strategies for drug release possess advantages and disadvantages, and the selection of the strategy used will depend on the targeted tissue and nature of the drug.
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Nelemans, Levi Collin, and Leonid Gurevich. "Drug Delivery with Polymeric Nanocarriers—Cellular Uptake Mechanisms." Materials 13, no. 2 (January 13, 2020): 366. http://dx.doi.org/10.3390/ma13020366.

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Nanocarrier-based systems hold a promise to become “Dr. Ehrlich’s Magic Bullet” capable of delivering drugs, proteins and genetic materials intact to a specific location in an organism down to subcellular level. The key question, however, how a nanocarrier is internalized by cells and how its intracellular trafficking and the fate in the cell can be controlled remains yet to be answered. In this review we survey drug delivery systems based on various polymeric nanocarriers, their uptake mechanisms, as well as the experimental techniques and common pathway inhibitors applied for internalization studies. While energy-dependent endocytosis is observed as the main uptake pathway, the integrity of a drug-loaded nanocarrier upon its internalization appears to be a seldomly addressed problem that can drastically affect the uptake kinetics and toxicity of the system in vitro and in vivo.
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50

Lacroce, Elisa, Paola Saccomandi, and Filippo Rossi. "Can gold nanoparticles improve delivery performance of polymeric drug-delivery systems?" Therapeutic Delivery 12, no. 7 (July 2021): 489–92. http://dx.doi.org/10.4155/tde-2021-0037.

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