Dissertations / Theses on the topic 'Polymeric drug delivery systems'
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Ketkar, Amol Sharad. "Polymeric drug delivery systems /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487859879937796.
Full textPark, Jung-Hwan. "Polymeric microneedles for transdermal drug delivery." Diss., Available online, Georgia Institute of Technology, 2004:, 2004. http://etd.gatech.edu/theses/available/etd-06072004-131324/unrestricted/park%5Fjung-hwan%5F200405%5Fphd.pdf.
Full textZaid, Alkilani Ahlam. "Polymeric microneedle systems for transdermal drug delivery." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603301.
Full textLindell, Katarina. "An investigation of thermogelling aqueous systems of ethyl (hydroxyethyl) cellulose and ionic surfactants." Lund : Lund University, Dept. of Food Technology, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38100698.html.
Full textZhu, Chongyu. "Polymeric drug delivery systems for biological antimicrobial agents." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/91996/.
Full textMawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.
Full textChakrapani, Aravind. "Processing and characterization of polymer microparticles for controlled drug delivery systems." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164827297.
Full textDonnelly, L. "Synthesis and characterisation of novel polymeric drug delivery systems." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398150.
Full textBenzine, Youcef. "Enzymatically triggered polymeric drug delivery systems for colon targeting." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S036.
Full textChronic inflammatory bowel diseases (IBD) today affects close to 200,000 people in France. They are characterized by the inflammation of the wall of a part of the digestive tract. They usually include Ulcerative Colitis and Crohn’s disease. Both are chronic diseases that involve inflammation of the colonic mucosa. The main difference between Crohn’s disease and Ulcerative Colitis is the location and nature of inflammation. Crohn’s disease can affect any part of the GIT from mouth to anus but in most cases attacks the terminal ileum. In contrast, Ulcerative Colitis is restricted to the colon and the rectum. An ideal dosage form should effectively protect the drug in the stomach and small intestine and subsequently release the drug in the colon in a targeted and controlled manner. The objective of this work was to develop new drug delivery systems containing a polysaccharide (pectin, guar gum, inulin ...), which are degradable by the colonic bacteria and a hydrophobic thermoplastic polymer (ethylcellulose, polyurethane, polyvinyl acetate ...), which will reduce the hydrophilicity of the polysaccharide. The technique used for the preparation of these dosage forms is hot-melt extrusion. It is a continuous and free solvent process that allows the manufacturing of a dosage form called "extrudate" by forcing the soften material through an orifice. It has been demonstrated that extrudates based on polyvinyl acetate/polyurethane and inulin can minimize the release of a model active substance in the upper part of GIT due to the hydrophobic properties of polyvinyl acetate. Indeed, these extrudates uptake low amount of water and lose low dry mass upon exposure to media simulating the stomach and the small intestine. However, once in contact with the colonic flora, these systems show a considerable loss of mass due to the degradation of inulin by enzymes secreted by colonic bacteria. In another study, hot melt extrudates based on ethylcellulose blended with different types of polysaccharides (guar gum, inulin, corn starch, maltodextrin, pectin and chitosan) were studied for the development of controlled drug delivery systems. Anhydrous theophylline and diprophylline have been used as model drugs. This study was useful to set the extrusion parameters: temperature 100 °C; screw speed 30 rpm; feed rate 3 cc/min; 30 % dibutyl sebacate as a plasticizer. Importantly, hot melt extrudates based on ethylcellulose:guar gum blends offer an interesting potential as controlled drug delivery systems: They can be prepared at temperatures of about 100 °C, provide broad spectra of drug release patterns (in particular about constant drug release rates). Finally, hot melt extrudates remained stable after 1 year storage at ambient conditions
Pasqualin, Matteo. "Development of polymeric drug delivery systems for biotech products." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423393.
Full textDai primi anni 80 i passi avanti fatti nel campo della genetica e della proteomica, hanno portato ad un particolare interesse nei confronti dei prodotti biotecnologici, quali DNA e proteine. L’utilizzo terapeutico di queste entità, seppur non privo di difficoltà, è stato facilitato dalla loro produzione su larga scala. Proteine e sequenze oligonucleotidiche si sono rivelate interessanti come agenti terapeutici essendo molecole dotate d’elevatissima selettività/affinità per il recettore o il sito d’azione specifico. L’impiego farmaceutico può evidenziare alcuni svantaggi che ne possono limitare l’utilizzo, come ad esempio la suscettibilità alla degradazione da parte di proteasi e DNasi, la rapida clearance renale e l’immunogenicità. Per affrontare tali limiti, molti ricercatori hanno cercano soluzioni nel campo dei drug delivery sistems (DDSs). A tal proposito, sono stati sviluppati molti sistemi e la coniugazione al PEG (polietilen glicole) è risultata essere una delle più promettenti. La PEGhilazione, infatti, conferisce alle molecole coniugate maggiore solubilità e stabilità nei confronti della digestione proteolitica, una ridotta tendenza all’aggregazione ed una ridotta immunogenicità. Grazie a questi vantaggi ed alle particolari caratteristiche del PEG, ad oggi sono presenti nel mercato 12 composti PEGhilati: 9 sono proteine, un peptide, un aptamero ed una formulazione liposomiale (contenente doxorubicina). Le migliorie apportate ai profili farmacocinetici di questi farmaci biotech grazie all’uso di DDSs possono essere anche impiegate nel campo dell’ingegneria tessutale, dove le medesime problematiche sono di basilare importanza per lo sviluppo di scaffold per cellule, in grado di rilasciare fattori di crescita. Il polietilen glicole (PEG) è il polimero leader per la coniugazione di proteine. Negli ultimi anni diversi polimeri sono stati studiati per trovare una valida alternativa a questo polimero, ma la sua eccellente biocompatibilità e la conoscenza nel suo utilizzo non ha ancora portato nessun polimero ad essere realmente competitivo nei suoi confronti. Nonostante tutto, anche l’utilizzo del PEG presenta alcuni limiti, quali la non-biodegradabilità e la documentata presenza di anticorpi anti-PEG sviluppati in alcuni casi specifici. Per questo motivo si è alla ricerca di un polimero che possa validamente sostituire il PEG. Nella prima parte di questo lavoro di tesi è stato studiato l’acido ialuronico (HA) per la bioconiugazione di proteine (HAylation). Essendo biodegradabile, l’HA può essere vantaggioso rispetto al PEG. L’HA è un polimero endogeno ed è metabolizzato dalle ialuronidasi, inoltre ha il vantaggio di poter raggiungere una capacità di loading elevate rispetto al PEG, grazie alla presenza di gruppi funzionali ripetitivi in ciascun monomero. In questa parte del lavoro di tesi, la ricerca si è concentrata sullo studio della coniugazione dell’HA a due enzimi modello, Ribonuclease A e tripsina, e poi ad un interessante proteina per uso farmaceutico, l’insulina. Per evitare fenomeni di cross-linking, solo una parte dei gruppi carbossilici del polimero è stata coniugata ad uno spacer aldeidico, consentendo la coniugazione con i gruppi amminici delle proteine. Inoltre, modulando il pH di reazione si sono potuti ottenere coniugati con legame selettivo all’N-terminale (pH 6) oppure random (pH 8), sfruttando la differente pKa degli ammino gruppi nelle proteine. I primi coniugati ottenuti con gli enzimi Ribonuclease A e tripsina sono stati studiati verificandone l’attività residua rispetto alle proteine native. Tutti i coniugati, in particolare quelli ottenuti per legame selettivo all’N-terminale, mantengono una buona attività su piccoli substrati (diminuzione del 30%); solo il derivato HA-tripsina mantiene circa il 60% di attività residua nei confronti del substrato ad alto peso molecolare. Inoltre, sempre per HA-tripsina, si è trovata una maggiore stabilità nel tempo rispetto l’enzima nativo (mediamente 45%) e si è confermata la suscettibilità di entrambe i coniugati nei confronti della ialuronidasi. La valutazione del polimero come potenziale carrier per proteine è proseguita preparando dei coniugati con l’insulina bovina, come esempio di proteina farmacologicamente attiva. Sono stati sintetizzati due coniugati con modalità selettiva all’N-terminale a partire da polimeri con diverso grado di modifica con gruppi aldeidici, pari a 4 e 21% e si sono ottenuti prodotti con il 17 e 32% (p/p), rispettivamente, di loading proteico. L’efficacia terapeutica dei coniugati in comparazione con l’insulina è stata testata su ratti Sprague Dawley con diabete indotto. Il coniugato con un minore loading proteico si è rivelato essere più efficace e con una riduzione dei livelli di glucosio nel sangue più prolungata. Nella seconda parte di questo lavoro di tesi si è studiata un’innovativa strategia di PEGhilazione enzimatica di sequenze oligonucleotidiche al fine di sviluppare questo approccio per il delivery di oligonucleotidi. Il metodo è stato messo a punto con sequenze nucleotidiche modello e l’approccio è stato il seguente: una breve sequenza oligonucleotica viene legata chimicamente ad una catena di PEG. Poi, mediante l’azione catalitica della T4 DNA ligase la porzione di PEG-DNA viene coniugata ad un’altra sequenza oligonucleotidica. Per lo studio di PEGhilazione enzimatica si è ideato un modello costituito da 4 sequenze oligonucleotidiche di riferimento: due coppie complementari terminanti con sticky-ends complementari a loro volta (18-mer + 21-mer e 16-mer + 19-mer). L’oligo di 18 nucleotidi portava in posizione 5’ una funzione tiolica, che è stata impiegata per la coniugazione col polimero. Dopo aver apportato alcune variazioni ai protocolli classici di ligazione si sono ottenuti ottimi risultati: completa ligazione del modello PEGhilato ed assenza di prodotti indesiderati. Un’ulteriore conferma di ligazione del modello PEGhilato si è ottenuta tramite digestione con EcoRI. Infatti, solamente dopo la ligazione è possibile trovare nella sequenza oligonucleotidica il sito di restrizione dell’enzima. In presenza o in assenza di polimero la restrizione è avvenuta completamente. Si è poi voluto indagare se una sequenza PEGhilata con un numero di basi ridotto potesse comunque mantenere i requisiti per essere substrato della T4 DNA ligase. Così, la coppia di sequenze complementari designata alla PEGhilazione è stata ridotta alla meta della sua lunghezza (9-mer + 12-mer). Anche con la sequenza PEGhilata così accorciata la ligazione è avvenuta completamente. In conclusione questo lavoro di tesi ha dimostrato che l’HA può essere una promettente alternativa al più noto PEG per la modifica di proteine. Nell’ambito del delivery di oligonucleotidi lo sviluppo di un approccio enzimatico di coniugazione può aprire nuovi orizzonti in questo settore il cui potenziale non è stato ancora esplorato.
Zhang, Feng. "Hot-melt extrusion as a novel technology to prepare sustained-release dosage forms /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Full textChang, Kai. "Structural modification of poly(n-isopropylacrylamide) for drug delivery applications." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48947.
Full textHeffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.
Full textCommittee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.
Basu, Sarkar Arindam Kochak Gregory Michael. "Carbohydrate nanoparticles a novel drug delivery platform for the systemic route /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/BASU_SARKAR_26.pdf.
Full textDeadman, Claire Michelle. "Biopharmaceutical studies of slow release, subcutaneous polymeric drug delivery systems." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433154.
Full textMishra, Kaushik. "Folate Receptor-Targeted Polymeric Micellar Nanocarriers as Drug Delivery Systems." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1629218263972419.
Full textBragger, Janine Lesley. "The design of drug delivery systems for the colon." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307587.
Full textYang, Stephen Chen. "Polyketals a new drug delivery platform for treating acute liver failure /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31785.
Full textCommittee Chair: Murthy, Niren; Committee Member: Bellamkonda, Ravi; Committee Member: Davis, Michael; Committee Member: May, Sheldon; Committee Member: Milam, Valeria. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Li, Ying Jean Y. C. "Free volume properties of drug delivery polymers studied by positron annihilation spectroscopy." Diss., UMK access, 2004.
Find full text"A dissertation in chemistry and software architecture." Advisor: Yan-Ching Jean. Typescript. Vita. Description based on contents viewed Feb. 27, 2006; title from "catalog record" of the print edition. Includes bibliographical references (leaves 205-218). Online version of the print edition.
Romão, Joana Isabel Sobral. "Development of cyclodextrin-hydrogel polymeric systems in scCO2 for drug delivery." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6134.
Full textThis work describes the studies on the development of new cyclodextrin-hydrogel systems in supercritical carbon dioxide (scCO2) with potential application in drug delivery. Three β-cyclodextrin (CDs) derivatives were synthesized: 6-monoacryloyl-β-CD, 2-monoacryloyl-β-CD and 6-monoacryloly-heptakis-(2,3-di-O-benzyl)-β-CD. Their structures were assigned by nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometry (MS) using the technique of matrix-assisted laser desorption/ionisation-time-of-flight (MALDI-TOF). These functionalized β-CDs were co-polymerized in scCO2 and the resulting co-polymers were characterized by high resolution magnetic angle spinning (HR-MAS) NMR. Swelling tests were performed showing that the presence of CD decreases the swelling capacity of the corresponding co-polymers. The β-CD co-polymers were impregnated with a model drug, metronidazole, using a batch supercritical fluid impregnation process. Experiments in vitro were realized in order to evaluate the performance of the cyclodextrin-hydrogel system as drug release device at different pHs, 2.2 and 7.4. The co-polymer with 2.5 % of 2-monoacryloyl-β-CD was the one that impregnated more drug and showed more interesting results, since at pH 2.2 the release is more controlled. The effect of the percentage of β-CD in the co-polymers performance was also investigated. The co-polymer with more percentage of 2-monoacryloyl-β-CD (8.8%) showed a more controlled drug release at pH 7.4. The results with 2.5 % of β-CD indicate that the co-polymer would be more suitable for oral administration, whereas with 8.8 % would be suitable for parenteral administration.
Bailly, Nathalie. "N-vinylpyrrolidone-vinyl acetate block copolymers as drug delivery vehicles." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20133.
Full textENGLISH ABSTRACT: The primary aim of this study was to investigate the feasibility of the amphiphilic block copolymer poly((vinylpyrrolidone)-b-poly(vinyl acetate)) (PVP-b-PVAc) as a vehicle for hydrophobic anti-cancer drugs. PVP-b-PVAc block copolymers of constant hydrophilic PVP block length and varying hydrophobic PVAc block lengths were synthesized via xanthate-mediated controlled radical polymerization (CRP). The methodology consisted of growing the PVAc chain from a xanthate end-functional PVP. In an aqueous environment the amphiphilic block copolymers selfassembled into spherical vesicle-like structures consisting of a hydrophobic PVAc bilayer membrane, a hydrophilic PVP corona and an aqueous core. The self-assembly behaviour and the physicochemical properties of the self-assembled structures were investigated by 1H NMR spectroscopy, fluorescence spectroscopy, transmission electron microscopy (TEM) and dynamic and static light scattering. Drug loading studies were performed using a model hydrophobic drug, clofazimine, and a common anti-cancer drug paclitaxel (PTX) to evaluate the potential of the PVP-b-PVAc block copolymers for drug delivery,. Clofazimine and PTX were physically entrapped into the hydrophobic domain of the self-assembled PVP-b-PVAc block copolymers via the dialysis method. The drug-loaded PVP-b-PVAc block copolymers were characterized regarding particle size, morphology, stability and drug loading capacity in order to assess their feasibility as a drug vehicle. The polymer vesicles had a relatively high drug loading capacity of 20 wt %. The effect of the hydrophobic PVAc block length on the drug loading capacity and encapsulation efficiency were also studied. Drug loading increased with increasing the hydrophobic PVAc block length. The effect of the drug feed ratio of clofazimine and PTX on the drug loading capacity and encapsulation efficiency were also investigated. The optimal formulation for the drug-loaded PVP-b-PVAc was determined and further investigated in vitro. The size stability of the drugloaded PVP-b-PVAc block copolymers was also assessed under physiological conditions (PBS, pH 7.4, 37 °C) and were stable in the absence and presence of serum. PVP-b-PVAc block copolymers were tested in vitro on MDA-MB-231 multi-drug-resistant human breast epithelial cancer cells and normal MCF12A breast epithelial cells to provide evidence of their antitumor efficacy. In vitro cell culture studies revealed that the PVP-b-PVAc drug carrier exhibited no cytotoxicity towards MDA-MB-231 and MCF12A cells, confirming the biocompatibility of the PVP-b-PVAc carrier. In vitro cytotoxicity assays using clofazimine-PVPb- PVAc formulations showed that when MDA-MB-231 cells were exposed to the formulations, an enhanced therapeutic effect was observed compared to the free drug. Cellular internalization of the PVP-b-PVAc drug carrier was demonstrated by fluorescent labeling of the PVP-b-PVAc carrier. Fluorescence microscopy results showed that the carrier was internalized by the MDAMB- 231 cells after 3 hours and localized in the cytoplasm and the perinuclear region. Overall, it was demonstrated that PVP-b-PVAc block copolymers appear to be promising candidates for the delivery of hydrophobic anti-cancer drugs.
AFRIKAANSE OPSOMMING: Die studie is gebaseer op die gebruik van amfifieliese blokkopolimere van poli((Nvinielpirolidoon)- b-poli(vinielasetaat)) (PVP-b-PVAc) as potensiële geneesmiddeldraers. PVP-b-PVAc blokkopolimere van konstante hydrofiliese bloklengte en verskillende hydrofobiese bloklengte is voorberei via die RAFT/MADIX-proses. Blokkopolimere met vinielasetaat is vanaf poli(N-vinielpirolidoon) met ‘n xantaatendfunksie voorberei. In ‘n wateromgewing vorm die PVP-b-PVAc blokkopolimere vesikel strukture met ‘n hydrofobiese membraan en ‘n hydrofiliese mantel. Die fisies-chemiese eienskappe van die PVP-b-PVAc blokkopolimere is gekarakteriseerd met gebruik van KMR spektroskopie, fluoresent spektroskopie, transmissie elektronmikroskopie (TEM) en dinamiese en statiese lig verstrooiing. Die potensiaal van PVP-b-PVAc as ‘n geneesmiddeldraer is ondersoek deur gebruik te maak van die hydrofobiese geneesmiddel, clofazimine, en ‘n anti-kanker geneesmiddel, paclitaxel. Clofazimine en paclitaxel is ge-inkapsuleer in die hydrofobiese gedeelte van die blokkopolimere via die dialise-metode. Clofazimine-PVP-b-PVAc en paclitaxel-PVPb- PVAc blokkopolimere is gekarakteriseerd met betrekking tot die partikel grootte, morfologie, stabiliteit en laai kapasitiet om die PVP-b-PVAc blokkopolimere as geneesmiddeldraers te evalueer. Die PVP-b-PVAc geneesmiddeldraer het ‘n relatiewe hoë laai kapsiteit van 20 gew % aangetoon. Die invloed van die bloklengte op die laai kapasitiet is ook ondersoek en beskryf. ‘n Toename in die laai kapasitiet is gesien met ‘n toename in die hydrofobiese bloklengte. Die invloed van die hoeveelheid geneesmiddel op die laai kapasitiet en die inkapsuleer doeltreffendheid is ook ondersoek. Die optimale formulasie is gevind en verder gebruik vir in vitro studies. Die stabiliteit van die geneesmiddeldraer in fisiologiese omstandighede (pH 7.4, 37 °C) is ook beskryf. Resultate toon aan dat die sisteem stabiel is onder hierdie omstandighede in die afwesigheid en aanwesigheid van serum. In vitro eksperimente is op MCF12A epiteel-borsselle en MDA-MB-231 epiteelborskankerselle getoets om die anti-tumoraktiwiteit te ondersoek. Resultate toon aan dat die PVP-b-PVAc geen sitotoxiese effek op die selle het nie, wat aandui dat die polimere bioverenigbaar is. Verder is dit bewys dat die PVP-b-PVAc geneesmiddel formualsie ’n hoër sitotoxisiteit besit as die vry-geneesmiddel. Fluoresent studies het aangetoon dat die geneesmiddeldraer na 3 uur opgeneen word deur MDA-MB231 selle en gelokaliseerd is in die sitoplasma en in die omgewing van die kern van die selle. In die algemeen is dit aangetoon dat PVP-b-PVAc blokkopolimere potensiële kandidate vir die lewering van hydrofobiese geneesmiddels is.
Ogden, Dorothy. "Modifiable Hyperbranched Polyester Drug Delivery Systems." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1316178520.
Full textSwami, Salesh N., University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." THESIS_CSTE_SFH_Swami_S.xml, 2004. http://handle.uws.edu.au:8081/1959.7/698.
Full textDoctor of Philosophy (PhD)
Grandelli, Heather Eilenfield. "Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23891.
Full textPh. D.
Gates, Kimberly Ann. "Controlled drug delivery using bioerodible polymeric systems for the treatment of periodontitis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41022.pdf.
Full textPywell, E. J. "Studies on some polymeric matrices for use in transdermal drug delivery systems." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378309.
Full textChan, Yannie Ka Yan Chemical Sciences & Engineering Faculty of Engineering UNSW. "Development of acid-cleavable polymeric nano/microparticles for delivery of therapeutics." Awarded by:University of New South Wales. Chemical Sciences & Engineering, 2007. http://handle.unsw.edu.au/1959.4/40442.
Full textEisenbrey, John Wheatley Margaret A. "Ultrasound sensitive polymeric drug carriers for treatment of solid tumors /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3218.
Full textNguyen, Duong Thuy. "Self-assembly Polymeric Nanoparticles Composed of Polymers Crosslinked with Transition Metals for Use in Drug Delivery." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822738/.
Full textSwami, Salesh N. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." Thesis, View thesis, 2004. http://handle.uws.edu.au:8081/1959.7/698.
Full textKomurcu, Ramazan. "Tryptamine terminated 1st generation polyamide dendrimer synthesis and drug release /." Akron, OH : University of Akron, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1196653318.
Full text"December, 2007." Title from electronic thesis title page (viewed 02/25/2008) Advisor, Stephanie T. Lopina; Faculty readers, Bi-min Newby, Helen Qammar; Department Chair, Lu-Kwang Ju; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
Hans, Meredith L. Lowman Anthony M. "Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860/741.
Full textMahaguna, Vorapann. "Investigation of cellulose ether polymers in controlled drug delivery." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037524.
Full textSutton, Damon Michael. "PH SENSITIVE RNA AND DRUG DELIVERY SYSTEMS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1179847644.
Full textSwami, Salesh N. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." View thesis, 2004. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20050729.124150/index.html.
Full textTeng, Yue. "Solubilization and release studies of small molecules in polymeric micelles /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Full textSwai, Hulda Paulo Shaidi. "Water sorption and drug release behaviour of polymeric systems based on heterocyclic/cyclic methacrylates." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313482.
Full textLofton, Megan Christina. "Development of a small molecule drug delivery vehicle for treatment of chronic pulmonary diseases." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24706.
Full textGiglio, Valentina. "Biofunctionalized systems for drug discovery and delivery." Doctoral thesis, Università di Catania, 2016. http://hdl.handle.net/10761/3893.
Full textMackenzie, R. C. "Computational modelling of polymer-based drug delivery systems." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28852/.
Full textMcCarron, Paul A. "Design and evaluation of polymeric drug delivery systems for the treatment of cervical intraepithelial neoplasia." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359100.
Full textRodríguez, Escalona Gabriela de Jesús. "DEVELOPMENT OF CONTROLLED DRUG DELIVERY SYSTEMS OF POLYMERIC NANOMEDICINES ASSOCIATED TO SCAFFOLDS FOR TISSUE REGENERATION." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/63231.
Full text[ES] Actualmente, una de las mayores preocupaciones que permanentemente laman la atención de los principales sectores de la sociedad humana es la salud. La ciencia médica moderna está comprometida no solo con suministrar tratamientos adecuados, sino más bien ofrecer soluciones efectivas y específicas para cada tipo de enfermedad o patología humana. En este sentido, estrategias innovadoras como la ingeniería de tejidos o la medicina regenerativa, los sistemas de liberación controlada de fármacos y las nanomedicinas, surgen como buenas alternativas para abordar situaciones difíciles de resolver aplicando los tratamientos y estrategias terapéuticas convencionales, como es el caso cuando se hace necesario reemplazar tejidos o incluso órganos dañados por algún traumatismo o enfermedad. Concretamente, el presente trabajo de investigación tiene por objetivo principal diseñar un sistema combinado para la liberación controlada, estable y localizada de agentes terapéuticos que sean capaces de ejercer su efecto de forma selectiva sobre la zona que amerita el tratamiento. Este constructo tendrá la versatilidad suficiente como para poder adaptarse a casi cualquier tipo de tratamiento, desde el cáncer hasta la regeneración de tejido, siempre que el requisito clave del tratamiento sea la necesidad de suministrar el tratamiento de manera localizada, estable y controlada. Para efectos de facilitar la compresión y el diseño del sistema se escogió para la prueba de concepto materiales y fármacos asociados a la regeneración de tejidos, como tratamiento para casos de heridas crónicas. El sistema en cuestión está constituido por tres elementos principales: 1) El primer elemento son los conjugados poliméricos de agentes terapéuticos que contribuirán a aumentar la selectividad de la acción terapéutica del fármaco, así como también a mejora la estabilidad, biodisponibilidad y biocompatibilidad de los mismos. En caso de que el fármaco sea hidrofóbico, la conjugación contribuye a aumentar su solubilidad en agua, y en el caso de usar proteínas como agentes terapéuticos, la conjugación contribuye a disminuir la respuesta inmunológica del cuerpo incrementando las posibilidad de éxito del tratamiento. 2) El segundo elemento son micropartículas poliméricas biodegradables, que en este caso actúan con agentes de encapsulación para los conjugados poliméricos, permitiendo así contar con un segundo punto de control en la cinética de liberación de los agentes terapéuticos. Simultáneamente, las micropartículas también cumplen un papel de modificador de la textura del constructo final, adjudicándole propiedades mecánica y fisicoquímicas que contribuyen a mejorar las propiedades biológicas del material final, como son la afinidad, la adhesión y la proliferación celular. 3) El tercer elemento consiste en una membrana polimérica biodegradable nanoporosa hecha por electrospinning, que constituyen el elemento unificados del sistema, aporta manejabilidad al constructo y es en sí mismo el último punto de control en la cinética de liberación del agente terapéutico. Este último debe ser biocompatible y estable en condiciones ambientales, puesto que probablemente este expuesto al ambiente mientras protege la herida, en el caso concreto de este tipo de aplicación. Estos tres elementos, que en sí mismos constituyen sistemas complejos por separado, se han combinado sistemáticamente para alcanzar una relación sinérgica entre ellos de manera que cada uno potencia las cualidades de los otros dos. El constructo resultante se caracterizó demostrando tener propiedades características que se pueden utilizar como parámetro de control durante la fabricación del mismo. Así mismo estudios in vitro del sistema desarrollado señalan que puede ser un buen candidato para el tratamiento de heridas crónicas entre otras patologías que requieran tratamientos localizados.
[CAT] Actualment, una de les majors preocupacions que permanentment llepen l'atenció dels principals sectors de la societat humana és la salut. La ciència mèdica moderna està compromesa no solament amb subministrar tractaments adequats, sinó més aviat oferir solucions efectives i específiques per a cada tipus de malaltia o patologia humana. En aquest sentit, estratègies innovadores com l'enginyeria de teixits o la medicina regenerativa, els sistemes d'alliberament controlat de fàrmacs i les nanomedicines, sorgeixen com a bones alternatives per a abordar situacions difícils de resoldre aplicant els tractaments i estratègies terapèutiques convencionals, com és el cas quan es fa necessari reemplaçar teixits o fins i tot òrgans danyats per algun traumatisme o malaltia. Concretament, el present treball de recerca té per objectiu principal dissenyar un sistema combinat per a l'alliberament controlat, estable i localitzada d'agents terapèutics que seguen capaços d'exercir el seu efecte de forma selectiva sobre la zona que amirita el tractament. Aquest constructe tindrà la versatilitat suficient com per a poder adaptar-se a quasi qualsevol tipus de tractament, des del càncer fins a la regeneració de teixit, sempre que el requisit clau del tractament sega la necessitat de subministrar el tractament de manera localitzada, estable i controlada. Per a efectes de facilitar la compressió i el disseny del sistema es va escollir per a la prova de concepte materials i fàrmacs associats a la regeneració de teixits, com a tractament per a casos de ferides cròniques. El sistema en qüestió està constituït per tres elements principals: 1) El primer element són els conjugats polimèrics d'agents terapèutics que contribuiran a augmentar la selectivitat de l'acció terapèutica del fàrmac, així com també a millora l'estabilitat, biodisponibilitat i biocompatibilitat dels mateixos. En cas que el fàrmac sega hidrofòbic, la conjugació contribueix a augmentar la seua solubilitat en aigua, i en el cas d'usar proteïnes com a agents terapèutics, la conjugació contribueix a disminuir la resposta immunològica del cos incrementant les possibilitat d'èxit del tractament. 2) El segon element són microparticles polimèriques biodegradables, que en aquest cas actuen amb agents d'encapsulació per als conjugats polimèrics, permetent així comptar amb un segon punt de control en la cinètica d'alliberament de l'agent terapèutics. Simultàniament, les microparticles també compleixen un paper de texturitzant del constructe final, adjudicant-li propietats mecànica i fisicoquímiques que contribueixen a millorar la propietats biològiques del material final, com són l'afinitat, l'adhesió i la proliferació cel·lular. 3) El tercer element consisteix en una membrana polimèrica biodegradable nanoporosa feta per electrospinning, que constitueixen el element unificats del sistema, aporta manejabilitat al constructe i és en si mateix el ultimi punt de control en la cinètica d'alliberament de l'agent terapèutic. Aquest últim ha de ser biocompatible i estable en condicions ambientals, ja que probablement aquest exposat a l'ambient mentre protegeix la ferida, en el cas concret d'aquest tipus d'aplicació. Aquests tres elements que en si mateixos constitueixen sistemes complexos per separat, s'han combinat sistemàticament per a aconseguir una relació sinergètica entre ells de manera que cadascun potencia les qualitats dels altres dos. El constructe resultant es va caracteritzar demostrant tenir propietats característiques que es poden utilitzar com a paràmetre de control durant la fabricació del mateix. Així mateix estudis in vitro del sistema desenvolupat assenyalen que pot ser un bon candidat per al tractament de ferides cròniques entre altres patologies que requeriren tractaments localitzats.
Rodríguez Escalona, GDJ. (2016). DEVELOPMENT OF CONTROLLED DRUG DELIVERY SYSTEMS OF POLYMERIC NANOMEDICINES ASSOCIATED TO SCAFFOLDS FOR TISSUE REGENERATION [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/63231
TESIS
FIORENTINI, FABRIZIO. "Development and fabrication of plant-based drug delivery polymeric systems for skin wound healing applications." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1092253.
Full textTison, Christopher Kirby. "Programmable, isothermal disassembly of DNA-linked colloidal particles." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28189.
Full textCommittee Chair: Milam, Valeria; Committee Member: Boyan, Barbara; Committee Member: Li, Mo; Committee Member: McDevitt, Todd; Committee Member: Sandhage, Ken.
Repka, Michael Andrew. "Physical-mechanical and chemical properties of topical films produced by hot-melt extrusion /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.
Full textBaki, Mert. "Bone Marrow Targeted Liposomal Drug Delivery Systems." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613251/index.pdf.
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) upon bone marrow transplantation (BMT). There is a need for increasing homing efficiency after BMT since only 10-15% of the transplanted cells can home to their own niches and a limited amount of donor marrow can be transplanted. In this study, we aimed to develop and characterize bone marrow targeted liposomal SDF-1&alpha
delivery system prepared by extrusion method. Alendronate conjugation was chosen to target the liposomes to bone marrow microenvironment, particularly the endosteal niche. Optimization studies were conducted with the model protein (
Bhide, Mahesh. "Nitric oxide delivery from polymeric wound dressings." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1144940498.
Full text"May, 2006." Title from electronic dissertation title page (viewed 10/11/2006). Advisor, Daniel J. Smith; Committee members, Michael J. Taschner, Wiley J. Youngs, Kim C. Calvo, Darrell H. Reneker; Department Chair, Michael J. Taschner; Dean of the College, Ronald F. Levant; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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Full textSoane, Robert J. "Bioadhesive polymers as intranasal drug delivery systems for peptide and protein drugs." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298078.
Full textGlässl, Bianca. "On the importance of drug-polymer interactions in controlled drug delivery systems." Lille 2, 2009. http://www.theses.fr/2009LIL2S026.
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