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Journal articles on the topic 'Polyketals'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Ito, Shingo, Wenhan Wang, Katsuyuki Nishimura, and Kyoko Nozaki. "Formal Aryne/Carbon Monoxide Copolymerization To Form Aromatic Polyketones/Polyketals." Macromolecules 48, no. 7 (April 3, 2015): 1959–62. http://dx.doi.org/10.1021/acs.macromol.5b00315.

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2

Whiting, Bryan T., and Geoffrey W. Coates. "Synthesis and Polymerization of Bicyclic Ketals: A Practical Route to High-Molecular Weight Polyketals." Journal of the American Chemical Society 135, no. 30 (July 19, 2013): 10974–77. http://dx.doi.org/10.1021/ja405581r.

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3

Lee, Woo Young, and Chang Hee Park. "Orthocyclophanes. 2. Starands, a new family of macrocycles of spirobicyclic polyketals with a 2n-crown-n moiety." Journal of Organic Chemistry 58, no. 25 (December 1993): 7149–57. http://dx.doi.org/10.1021/jo00077a044.

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4

LEE, W. Y., and C. H. PARK. "ChemInform Abstract: Orthocyclophanes. Part 2. Starands, a New Family of Macrocycles of Spirobicyclic Polyketals with a 2n-Crown-n Moiety." ChemInform 25, no. 16 (August 19, 2010): no. http://dx.doi.org/10.1002/chin.199416209.

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5

Shenoi, Rajesh A., Jayaprakash K. Narayanannair, Jasmine L. Hamilton, Benjamin F. L. Lai, Sonja Horte, Rajesh K. Kainthan, Jos P. Varghese, Kallanthottathil G. Rajeev, Muthiah Manoharan, and Jayachandran N. Kizhakkedathu. "Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells." Journal of the American Chemical Society 134, no. 36 (August 30, 2012): 14945–57. http://dx.doi.org/10.1021/ja305080f.

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6

Maity, Santanu, Priya Choudhary, Manu Manjunath, Aditya Kulkarni, and Niren Murthy. "A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy." Chemical Communications 51, no. 88 (2015): 15956–59. http://dx.doi.org/10.1039/c5cc05242d.

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7

Wang, Yang, Baisong Chang, and Wuli Yang. "pH-Sensitive Polyketal Nanoparticles for Drug Delivery." Journal of Nanoscience and Nanotechnology 12, no. 11 (November 1, 2012): 8266–75. http://dx.doi.org/10.1166/jnn.2012.6677.

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8

Fiore, Vincent F., Megan C. Lofton, Susanne Roser-Page, Stephen C. Yang, Jesse Roman, Niren Murthy, and Thomas H. Barker. "Polyketal microparticles for therapeutic delivery to the lung." Biomaterials 31, no. 5 (February 2010): 810–17. http://dx.doi.org/10.1016/j.biomaterials.2009.09.100.

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9

Iwan, Agnieszka, Bozena Kaczmarczyk, Janusz Kasperczyk, Jan Jurusik, Henryk Janeczek, Danuta Sek, and Zbigniew mazurak. "Polyketanils. Polymers protonated with Bronsted acid." Journal of Polymer Science Part A: Polymer Chemistry 44, no. 19 (2006): 5645–60. http://dx.doi.org/10.1002/pola.21705.

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10

Lee, Sungmun, Stephen C. Yang, Michael J. Heffernan, W. Robert Taylor, and Niren Murthy. "Polyketal Microparticles: A New Delivery Vehicle for Superoxide Dismutase." Bioconjugate Chemistry 18, no. 1 (January 2007): 4–7. http://dx.doi.org/10.1021/bc060259s.

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11

Bittner, Magalis, Fidelina Gonzalez, Hugo Valdebenito, Mario Silva, Valerie J. Paul, William Fenical, Marie H. M. Chen, and Jon Clardy. "A novel tetracyclic polyketal from the marine red alga." Tetrahedron Letters 28, no. 35 (January 1987): 4031–32. http://dx.doi.org/10.1016/s0040-4039(01)83853-3.

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12

Guo, Shutao, Yoshiyuki Nakagawa, Aoune Barhoumi, Weiping Wang, Changyou Zhan, Rong Tong, Claudia Santamaria, and Daniel S. Kohane. "Extended Release of Native Drug Conjugated in Polyketal Microparticles." Journal of the American Chemical Society 138, no. 19 (May 5, 2016): 6127–30. http://dx.doi.org/10.1021/jacs.6b02435.

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13

Heffernan, Michael J., and Niren Murthy. "Polyketal Nanoparticles: A New pH-Sensitive Biodegradable Drug Delivery Vehicle." Bioconjugate Chemistry 16, no. 6 (November 2005): 1340–42. http://dx.doi.org/10.1021/bc050176w.

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14

Wang, Shaobai, Kangzhou Xie, and Donglin Tang. "Benign oxidation of PVA for configuration of reversible polyketal networks." European Polymer Journal 140 (November 2020): 110050. http://dx.doi.org/10.1016/j.eurpolymj.2020.110050.

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15

Sek, Danuta, Agnieszka Iwan, and Henryk Janeczek. "Synthesis and Photoluminescence of Polyketanils with Aliphatic Chains." Polymer Journal 34, no. 12 (December 2002): 911–16. http://dx.doi.org/10.1295/polymj.34.911.

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16

Sęk, Danuta, Agnieszka Iwan, Janusz Kasperczyk, and Henryk Janeczek. "Synthesis and characterisation of polyketanils with ether linkages." Macromolecular Symposia 199, no. 1 (October 2003): 455–66. http://dx.doi.org/10.1002/masy.200350938.

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17

Darcel, Laurine, Sanjit Das, Isabelle Bonnard, Bernard Banaigs, and Nicolas Inguimbert. "Thirtieth Anniversary of the Discovery of Laxaphycins. Intriguing Peptides Keeping a Part of Their Mystery." Marine Drugs 19, no. 9 (August 24, 2021): 473. http://dx.doi.org/10.3390/md19090473.

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Lipopeptides are a class of compounds generally produced by microorganisms through hybrid biosynthetic pathways involving non-ribosomal peptide synthase and a polyketyl synthase. Cyanobacterial-produced laxaphycins are examples of this family of compounds that have expanded over the past three decades. These compounds benefit from technological advances helping in their synthesis and characterization, as well as in deciphering their biosynthesis. The present article attempts to summarize most of the articles that have been published on laxaphycins. The current knowledge on the ecological role of these complex sets of compounds will also be examined.

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18

Yang, Stephen C., Mahesh Bhide, Ian N. Crispe, Robert H. Pierce, and Niren Murthy. "Polyketal Copolymers: A New Acid-Sensitive Delivery Vehicle for Treating Acute Inflammatory Diseases." Bioconjugate Chemistry 19, no. 6 (June 2008): 1164–69. http://dx.doi.org/10.1021/bc700442g.

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19

Zhong, Haiping, Jingqing Mu, Yanyan Du, Zunkai Xu, Yang Xu, Na Yu, Shubiao Zhang, and Shutao Guo. "Acid-Triggered Release of Native Gemcitabine Conjugated in Polyketal Nanoparticles for Enhanced Anticancer Therapy." Biomacromolecules 21, no. 2 (January 29, 2020): 803–14. http://dx.doi.org/10.1021/acs.biomac.9b01493.

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20

Poziomek, E. J., M. E. Kronenberg, and E. Havinga. "Polyketal products in the oxidation of 1,2-di-2-pyridyl-1,2-ethenediol with iodine." Recueil des Travaux Chimiques des Pays-Bas 85, no. 8 (September 2, 2010): 800–802. http://dx.doi.org/10.1002/recl.19660850808.

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21

Rajagopal, Pratheppa, Giridhara R. Jayandharan, and Uma Maheswari Krishnan. "Evaluation of the Anticancer Activity of pH-Sensitive Polyketal Nanoparticles for Acute Myeloid Leukemia." Molecular Pharmaceutics 18, no. 5 (March 29, 2021): 2015–31. http://dx.doi.org/10.1021/acs.molpharmaceut.0c01243.

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22

Zhao, Menghui, Jiaqi Yao, Xiangxue Meng, Yaxin Cui, Tianyu Zhu, Fengying Sun, Youxin Li, and Lesheng Teng. "Polyketal Nanoparticles Co-Loaded With miR-124 and Ketoprofen for Treatment of Rheumatoid Arthritis." Journal of Pharmaceutical Sciences 110, no. 5 (May 2021): 2233–40. http://dx.doi.org/10.1016/j.xphs.2021.01.024.

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23

Tsai, Tsuimin, Chen-Yu Kao, Chun-Liang Chou, Lu-Chun Liu, and Tz-Chong Chou. "Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats." Journal of Microencapsulation 33, no. 5 (June 29, 2016): 401–11. http://dx.doi.org/10.1080/02652048.2016.1202344.

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24

IWAN, AGNIESZKA, and DANUTA SEK. "Modification of the structure and properties of polyketanils for applications in optoelectronics." Polimery 50, no. 07/08 (July 2005): 581–86. http://dx.doi.org/10.14314/polimery.2005.581.

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25

Lee, Woo Young, Chang Hee Park, and Sangsoo Kim. "A novel star-shaped crown ether: spontaneous isomerization of a macrocyclic polyketone to a spirobicyclic polyketal." Journal of the American Chemical Society 115, no. 3 (February 1993): 1184–85. http://dx.doi.org/10.1021/ja00056a074.

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26

Sohn, Young-Doug, Inthirai Somasuntharam, Pao-Lin Che, Rishim Jayswal, Niren Murthy, Michael E. Davis, and Young-sup Yoon. "Induction of pluripotency in bone marrow mononuclear cells via polyketal nanoparticle-mediated delivery of mature microRNAs." Biomaterials 34, no. 17 (June 2013): 4235–41. http://dx.doi.org/10.1016/j.biomaterials.2013.02.005.

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27

Somasuntharam, Inthirai, Archana V. Boopathy, Raffay S. Khan, Mario D. Martinez, Milton E. Brown, Niren Murthy, and Michael E. Davis. "Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction." Biomaterials 34, no. 31 (October 2013): 7790–98. http://dx.doi.org/10.1016/j.biomaterials.2013.06.051.

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28

Sy, Jay C., Edward A. Phelps, Andrés J. García, Niren Murthy, and Michael E. Davis. "Surface functionalization of polyketal microparticles with nitrilotriacetic acid–nickel complexes for efficient protein capture and delivery." Biomaterials 31, no. 18 (June 2010): 4987–94. http://dx.doi.org/10.1016/j.biomaterials.2010.02.063.

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29

Sek, D., A. Iwan, H. Janeczek, P. Rannou, and A. Pron. "New conjugated polyketanils: tuning of optical properties via chain design and protonic doping." Thin Solid Films 453-454 (April 2004): 362–66. http://dx.doi.org/10.1016/j.tsf.2003.11.107.

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30

Iwan, Agnieszka, Danuta Sȩk, and Janusz Kasperczyk. "Characterization and Photoluminescence Study of Blue and Green Emitting Polyketanils and Their Blends." Macromolecules 38, no. 10 (May 2005): 4384–92. http://dx.doi.org/10.1021/ma050102f.

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31

Iwan, Agnieszka, and Danuta Sek. "Processible polyazomethines and polyketanils: From aerospace to light-emitting diodes and other advanced applications." Progress in Polymer Science 33, no. 3 (March 2008): 289–345. http://dx.doi.org/10.1016/j.progpolymsci.2007.09.005.

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32

LEE, W. Y., C. H. PARK, and S. KIM. "ChemInform Abstract: A Novel Star-Shaped Crown Ether: Spontaneous Isomerization of a Macrocyclic Polyketone to a Spirobicyclic Polyketal." ChemInform 24, no. 24 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199324210.

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33

Iwan, Agnieszka, Zbigniew Mazurak, Bozena Kaczmarczyk, Bozena Jarzabek, and Danuta Sek. "Synthesis and characterization of polyketanils with 3,8-diamino-6-phenylphenanthridine moieties exhibiting light emitting properties." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 69, no. 2 (February 2008): 291–303. http://dx.doi.org/10.1016/j.saa.2007.04.001.

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34

Seshadri, Gokulakrishnan, Jay C. Sy, Milton Brown, Sergey Dikalov, Stephen C. Yang, Niren Murthy, and Michael E. Davis. "The delivery of superoxide dismutase encapsulated in polyketal microparticles to rat myocardium and protection from myocardial ischemia-reperfusion injury." Biomaterials 31, no. 6 (February 2010): 1372–79. http://dx.doi.org/10.1016/j.biomaterials.2009.10.045.

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35

Youssef, Fadia S., Elham Alshammari, and Mohamed L. Ashour. "Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling." International Journal of Molecular Sciences 22, no. 4 (February 13, 2021): 1866. http://dx.doi.org/10.3390/ijms22041866.

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Genus Aspergillus represents a widely spread genus of fungi that is highly popular for possessing potent medicinal potential comprising mainly antimicrobial, cytotoxic and antioxidant properties. They are highly attributed to its richness by alkaloids, terpenes, steroids and polyketons. This review aimed to comprehensively explore the diverse alkaloids isolated and identified from different species of genus Aspergillus that were found to be associated with different marine organisms regarding their chemistry and biology. Around 174 alkaloid metabolites were reported, 66 of which showed important biological activities with respect to the tested biological activities mainly comprising antiviral, antibacterial, antifungal, cytotoxic, antioxidant and antifouling activities. Besides, in silico studies on different microbial proteins comprising DNA-gyrase, topoisomerase IV, dihydrofolate reductase, transcriptional regulator TcaR (protein), and aminoglycoside nucleotidyl transferase were done for sixteen alkaloids that showed anti-infective potential for better mechanistic interpretation of their probable mode of action. The inhibitory potential of compounds vs. Angiotensin-Converting Enzyme 2 (ACE2) as an important therapeutic target combating COVID-19 infection and its complication was also examined using molecular docking. Fumigatoside E showed the best fitting within the active sites of all the examined proteins. Thus, Aspergillus species isolated from marine organisms could afford bioactive entities combating infectious diseases.

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36

Mitra, Kheyanath, Sumit Kumar Hira, Shikha Singh, Niraj Kumar Vishwakarma, Sambhav Vishwakarma, Uttam Gupta, Partha Pratim Manna, and Biswajit Ray. "In Vitro Anticancer Drug Delivery Using Amphiphilic Poly(N -vinylpyrrolidone)-b -Polyketal-b -Poly(N -vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier." ChemistrySelect 3, no. 31 (August 16, 2018): 8833–43. http://dx.doi.org/10.1002/slct.201801399.

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37

Iwan, Agnieszka, and Danuta Sek. "Effect of Chain Structure and Dopant on the Thermal and Optical Properties of Conjugated—non-conjugated Isomeric Polyketanils." High Performance Polymers 19, no. 2 (February 12, 2007): 194–212. http://dx.doi.org/10.1177/0954008306068295.

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38

Hira, Sumit Kumar, Kheyanath Mitra, Prateek Srivastava, Shikha Singh, Sambhav Vishwakarma, Ranjeet Singh, Biswajit Ray, and Partha Pratim Manna. "Doxorubicin loaded pH responsive biodegradable ABA-type Amphiphilic PEG-b-aliphatic Polyketal-b-PEG block copolymer for therapy against aggressive murine lymphoma." Nanomedicine: Nanotechnology, Biology and Medicine 24 (February 2020): 102128. http://dx.doi.org/10.1016/j.nano.2019.102128.

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39

Mitra, Kheyanath, Sumit Kumar Hira, Shikha Singh, Niraj Kumar Vishwakarma, Sambhav Vishwakarma, Uttam Gupta, Partha Pratim Manna, and Biswajit Ray. "Corrigendum: In Vitro Anticancer Drug Delivery Using Amphiphilic Poly( N ‐vinylpyrrolidone)‐ b ‐Polyketal‐ b ‐Poly( N ‐vinylpyrrolidone) Block Copolymer as Micellar Nanocarrier." ChemistrySelect 4, no. 40 (October 25, 2019): 11851. http://dx.doi.org/10.1002/slct.201903976.

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40

Iwan, Agnieszka, Janusz Kasperczyk, Bozena Kaczmarczyk, Henryk Janeczek, Jan Jurusik, Zbigniew Mazurak, and Danuta Sek. "Polyketanils: Preparation of π-Conjugated Polymer Bases from p-dibenzoylbenzene with Various Diamines. Protonation with DL-Camphor-10-sulfonic Acid." High Performance Polymers 19, no. 1 (October 23, 2006): 78–96. http://dx.doi.org/10.1177/0954008306071032.

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41

Heffernan, Michael J., Sudhir P. Kasturi, Stephen C. Yang, Bali Pulendran, and Niren Murthy. "The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)–poly(cytidylic acid)." Biomaterials 30, no. 5 (February 2009): 910–18. http://dx.doi.org/10.1016/j.biomaterials.2008.10.034.

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42

Yang, Junyu, Milton E. Brown, Hanshuo Zhang, Mario Martinez, Zhihua Zhao, Srishti Bhutani, Shenyi Yin, David Trac, Jianzhong Jeff Xi, and Michael E. Davis. "High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 312, no. 5 (May 1, 2017): H1002—H1012. http://dx.doi.org/10.1152/ajpheart.00685.2016.

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Myocardial infarction (MI) is the most common cause of heart failure. Excessive production of ROS plays a key role in the pathogenesis of cardiac remodeling after MI. NADPH with NADPH oxidase (Nox)2 as the catalytic subunit is a major source of superoxide production, and expression is significantly increased in the infarcted myocardium, especially by infiltrating macrophages. While microRNAs (miRNAs) are potent regulators of gene expression and play an important role in heart disease, there still lacks efficient ways to identify miRNAs that target important pathological genes for treating MI. Thus, the overall objective was to establish a miRNA screening and delivery system for improving heart function after MI using Nox2 as a critical target. With the use of the miRNA-target screening system composed of a self-assembled cell microarray (SAMcell), three miRNAs, miR-106b, miR-148b, and miR-204, were identified that could regulate Nox2 expression and its downstream products in both human and mouse macrophages. Each of these miRNAs were encapsulated into polyketal (PK3) nanoparticles that could effectively deliver miRNAs into macrophages. Both in vitro and in vivo studies in mice confirmed that PK3-miRNAs particles could inhibit Nox2 expression and activity and significantly improve infarct size and acute cardiac function after MI. In conclusion, our results show that miR-106b, miR-148b, and miR-204 were able to improve heart function after myocardial infarction in mice by targeting Nox2 and possibly altering inflammatory cytokine production. This screening system and delivery method could have broader implications for miRNA-mediated therapeutics for cardiovascular and other diseases. NEW & NOTEWORTHY NADPH oxidase (Nox)2 is a promising target for treating cardiovascular disease, but there are no specific inhibitors. Finding endogenous signals that can target Nox2 and other inflammatory molecules is of great interest. In this study, we used high-throughput screening to identify microRNAs that target Nox2 and improve cardiac function after infarction.

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43

"A New Monomer for High Molecular Weight Polyketals." Synfacts 9, no. 10 (September 17, 2013): 1059. http://dx.doi.org/10.1055/s-0033-1339803.

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44

Somasuntharam, Inthirai, Niren Murthy, and Michael Davis. "Abstract P032: Nanoparticle Mediated Nox2-siRNA Therapy for Preventing Cardiac Dysfunction Following Myocardial Infarction." Circulation Research 109, suppl_1 (December 9, 2011). http://dx.doi.org/10.1161/res.109.suppl_1.ap032.

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Myocardial infarction (MI) is the most common cause of heart failure in the developed world. Following MI, reactive oxygen species (ROS) play a key role in the pathogenesis of cardiac remodeling leading to impaired ventricular function. Oxidative stress at high levels lead to many of the injury associated changes: proinflammatory cytokine release, myocyte apoptosis, cardiac fibrosis and hypertrophy. Nicotinamide adenine denucleotide phosphate (NADPH) oxidase with Nox2 as the catalytic subunit, is a major source for cardiac ROS production. After MI, Nox2 expression is significantly increased in the infarcted myocardium. Moreover, mice lacking the Nox2 gene are protected from ischemic injury. We used polyketals, a new class of acid-degradable polymers, as delivery vehicles for Nox2-siRNA to the post-MI environment. When engaged by macrophages, present in high quantities during MI, these particles have been shown to be taken up by macrophages and contents released within cells in active form. Nox2-siRNA was ion-paired to the cationic lipid DOTAP, and spherical particles averaging 500nm diameter were made by a single emulsion procedure with polyketal PK3 using PVA as surfactant. While a commercially available transfection reagent yielded 7% uptake as measured by flow cytometery, 81% of macrophages were positive for fluorescently-labeled siRNA in PK3-siNOX2 treated cells. These data were confirmed with confocal microscopy. Macrophages treated with PK3-siNOX2 demonstrated a significant 43% knockdown in Nox2 gene expression at 24 hours, while no reduction was seen with scrambled siRNA or empty particles. Functional activity was assessed by a fluorescent dihyroethidium dye based HPLC quantification after phorbol 12-myristate 13-acetate stimulation following 72 hours of particle treatment to measure superoxide production. PK3-siNox2 treated cells exhibited a 41% reduction in activity, with no significant changes seen with scrambled siRNA or empty particle treatment. Currently, the therapeutic potential of the Nox2-siRNA particles is being evaluated in a mouse model of ischemia-reperfusion. Successful completion of these studies could lead to a novel treatment for post-infarction injury.

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45

Sęk, Danuta, and Agnieszka Iwan. "Molecular and supramolecular approaches for tuning properties of new polyketanils." e-Polymers 4, no. 1 (December 1, 2004). http://dx.doi.org/10.1515/epoly.2004.4.1.847.

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Abstract A new family of π-conjugated polyketanils was synthesized and thermal and optical properties of the polymers were tuned by ‘chain engineering’, consisting of the appropriate design of chain building blocks using diamines and diketones with various chemical structures, and ‘dopant engineering’ in which a specially designed multifunctional dopant was used, 1,2-(di-2-ethylhexyl) ester of 4-sulfophthalic acid, capable of specific interaction with the host polymer. The structure of the dopant creates a new type of supramolecular comb-shaped architecture in which the lateral groups, anions of the sulfophthalic acid residue, are ionically bonded to the main chain via protonation of ketimine nitrogen atoms. This specific interaction of the dopant with the host polymer influences the polyketanils’ properties and the following changes were observed: decreasing glass transition temperature and improvement of polymer film flexibility, as well as a bathochromic shift of the photoluminescence emission band.

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46

Gray, Warren D., Pao Lin Che, Milton Brown, Xinghai Ning, Niren Murthy, and Michael E. Davis. "Abstract P164: N-acetylglucosamine Conjugated to Nanoparticles Enhances Myocyte Uptake and Improves Delivery of a Small Molecule P38 Inhibitor for Postinfarct Healing." Circulation Research 109, suppl_1 (December 9, 2011). http://dx.doi.org/10.1161/res.109.suppl_1.ap164.

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An estimated 985,000 new myocardial infarctions (MI) will occur in the U.S. in 2011. While many will survive the initial insult, the early damage will eventually lead to heart failure for which the only definitive cure is transplantation. Cardiomyocyte (CM) apoptosis is a large contributor to cardiac dysfunction, and although potential therapeutic molecules exist to inhibit apoptotic pathways, drug delivery methods are lacking. This damage is largely regional and thus localized delivery of therapeutics holds great potential. However, CMs are relatively non-phagocytic, which precludes existing delivery schemes using polymeric particles that target phagocytic cells. Recently, the carbohydrate N-acetyl-glucosamine (GlcNAc) was discovered to be bound and internalized by CMs, providing a potential mechanism for drug delivery. Here we demonstrate efficacy of a drug delivery system comprising a drug-loaded biodegradable polyketal nanoparticle that is surface-decorated with GlcNAc. Inclusion of the sugar enhanced uptake by CMs in vitro as measured by intracellular activated fluorescence. When delivered in vivo following ischemia-reperfusion injury, GlcNAc-decorated particles loaded with the p38 inhibitor SB239063 reduced infarct size and improved acute cardiac function. This was in contrast to our published data demonstrating no acute effect of non-sugar decorated, p38 inhibitor-loaded particles. These data suggest a novel therapeutic option to enhance uptake of drug-loaded nanoparticles to CMs, and perhaps to reduce the large amount of CM cell death following myocardial injury.

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