Relevant bibliographies by topics / Polyketals

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'Polyketals'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Polyketals"

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Ito, Shingo, Wenhan Wang, Katsuyuki Nishimura, and Kyoko Nozaki. "Formal Aryne/Carbon Monoxide Copolymerization To Form Aromatic Polyketones/Polyketals." Macromolecules 48, no. 7 (April 3, 2015): 1959–62. http://dx.doi.org/10.1021/acs.macromol.5b00315.

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Whiting, Bryan T., and Geoffrey W. Coates. "Synthesis and Polymerization of Bicyclic Ketals: A Practical Route to High-Molecular Weight Polyketals." Journal of the American Chemical Society 135, no. 30 (July 19, 2013): 10974–77. http://dx.doi.org/10.1021/ja405581r.

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Lee, Woo Young, and Chang Hee Park. "Orthocyclophanes. 2. Starands, a new family of macrocycles of spirobicyclic polyketals with a 2n-crown-n moiety." Journal of Organic Chemistry 58, no. 25 (December 1993): 7149–57. http://dx.doi.org/10.1021/jo00077a044.

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LEE, W. Y., and C. H. PARK. "ChemInform Abstract: Orthocyclophanes. Part 2. Starands, a New Family of Macrocycles of Spirobicyclic Polyketals with a 2n-Crown-n Moiety." ChemInform 25, no. 16 (August 19, 2010): no. http://dx.doi.org/10.1002/chin.199416209.

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Shenoi, Rajesh A., Jayaprakash K. Narayanannair, Jasmine L. Hamilton, Benjamin F. L. Lai, Sonja Horte, Rajesh K. Kainthan, Jos P. Varghese, Kallanthottathil G. Rajeev, Muthiah Manoharan, and Jayachandran N. Kizhakkedathu. "Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells." Journal of the American Chemical Society 134, no. 36 (August 30, 2012): 14945–57. http://dx.doi.org/10.1021/ja305080f.

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Maity, Santanu, Priya Choudhary, Manu Manjunath, Aditya Kulkarni, and Niren Murthy. "A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy." Chemical Communications 51, no. 88 (2015): 15956–59. http://dx.doi.org/10.1039/c5cc05242d.

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Wang, Yang, Baisong Chang, and Wuli Yang. "pH-Sensitive Polyketal Nanoparticles for Drug Delivery." Journal of Nanoscience and Nanotechnology 12, no. 11 (November 1, 2012): 8266–75. http://dx.doi.org/10.1166/jnn.2012.6677.

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Fiore, Vincent F., Megan C. Lofton, Susanne Roser-Page, Stephen C. Yang, Jesse Roman, Niren Murthy, and Thomas H. Barker. "Polyketal microparticles for therapeutic delivery to the lung." Biomaterials 31, no. 5 (February 2010): 810–17. http://dx.doi.org/10.1016/j.biomaterials.2009.09.100.

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Iwan, Agnieszka, Bozena Kaczmarczyk, Janusz Kasperczyk, Jan Jurusik, Henryk Janeczek, Danuta Sek, and Zbigniew mazurak. "Polyketanils. Polymers protonated with Bronsted acid." Journal of Polymer Science Part A: Polymer Chemistry 44, no. 19 (2006): 5645–60. http://dx.doi.org/10.1002/pola.21705.

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Lee, Sungmun, Stephen C. Yang, Michael J. Heffernan, W. Robert Taylor, and Niren Murthy. "Polyketal Microparticles: A New Delivery Vehicle for Superoxide Dismutase." Bioconjugate Chemistry 18, no. 1 (January 2007): 4–7. http://dx.doi.org/10.1021/bc060259s.

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Dissertations / Theses on the topic "Polyketals"

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Yang, Stephen Chen. "Polyketals a new drug delivery platform for treating acute liver failure /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31785.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.
Committee Chair: Murthy, Niren; Committee Member: Bellamkonda, Ravi; Committee Member: Davis, Michael; Committee Member: May, Sheldon; Committee Member: Milam, Valeria. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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Somasuntharam, Inthirai. "Modulation of the immune response following myocardial infarction utilizing biomaterial-based therapeutic delivery strategies." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53854.

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In 2015, American Heart Association (AHA) reported that 1 in 9 deaths are attributed to Heart failure (HF), the number one killer in the world. While advancements in interventional cardiology in conjunction with pharmacotherapies have significantly reduced the rate of mortality following MI, there has been a corresponding rise in chronic heart failure (CHF) in surviving patients, largely attributed to the limited regenerative capacity of the heart and the inadequate healing response. Myocardial ischemic injury triggers an exuberant local and systemic inflammation, and the extent and quality of the cardiac wound healing process is intricately tied to the delicate equilibrium of this inflammatory response. While cardiac regeneration is an important goal, it is imperative in the meantime to explore therapeutic strategies that target these inflammatory mediators of early cardiac repair. These interventions to influence and improve cardiac wound healing can represent a new therapeutic window to halt the progression of heart failure between the few hours that may be used to limit infarct size by reperfusion and an irreversible non-contractile cardiac scar. This dissertation examines three therapeutic delivery strategies aimed at modulating the immune response to enhance cardiac repair in rodent models MI: 1) Polyketal nanoparticles as siRNA delivery vehicles for antioxidant therapy; 2) Spherical nucleic acid particles for anti-inflammatory therapy and; 3) Bioactive PEG (polyethyleneglycol)-based hydrogel for immunomodulation. The work presented here applies novel nucleic acid delivery strategies for cardiac gene silencing and has contributed to new knowledge with regard to modulating the immune response following MI.
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Sy, Jay Christopher. "Novel strategies for cardiac drug delivery." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39531.

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The American Heart Association (AHA) estimates that at least one American will die from a coronary event every minute, costing over $150 billion in 2008 alone. Regenerating the myocardium of patients that survive the initial infarction has proven to be an elusive goal. A variety of factors - including the loss of contractile cells, inflammatory response following infarction, cardiac hypertrophy, and lack of suitable cues for progenitor cells - causes fibrosis in the heart and loss of cardiac function. This dissertation examines three drug delivery strategies aimed at improving conditions for cardiac regeneration: polyketal microspheres as non-inflammatory drug delivery vehicles; surface functionalization of microparticles with nitrilotriacetic acid-nickel (NTA-Ni) for non-covalent tethering of proteins; and using Hoechst-inspired ligands for targeting extracellular DNA in necrotic tissue.
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Kao, Chen-Yu. "Local and sustained delivery of hydrophobic drugs to the spinal cord with polyketal microparticles." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37304.

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Amyotrophic lateral sclerosis (ALS) is a devastating disease. Currently, there is no cure for this disease, and effective treatment strategies are greatly needed. Calpain activation plays a major role in the motor neuron degeneration that causes ALS. Therefore, therapeutic strategies can inhibit calpain activity in the central nervous system (CNS) have great clinical potential. The calpain inhibitors AK295 and MDL-28170 have been demonstrated to be neuroprotective in animal models of neurological injury, and should have great potential to treat ALS; however delivery problems have hindered their clinical success. Therefore, development of a new strategy that can locally deliver the calpain inhibitors to the central nervous system could significantly improve the treatment of ALS. The objectives of my thesis research were (1) to develop high molecular weight polyketals that provide sustained release properties for hydrophobic molecules, (2) to formulate calpain inhibitor-encapsulated polyketal microparticles which have a release half life of one month in vitro, (3) and to evaluate the performance of polyketal microparticles for delivering calpain inhibitors to the spinal cord in vivo. In completing these specific aims, we have developed biodegradable polymeric microparticles for the delivery of calpain inhibitors, AK295 and MDL-28170 to treat ALS. The results of calpain assays showed that both AK-PKMs and MDL-PKMs maintained most of their inhibitory activities even after the robust emulsion process. The in vitro release profile of MDL-28170 in MDL-PKMs showed that 50 % of the drug was released in the first 30 days. Experiments using dye-encapsulated microparticles showed that polyketal microparticles (1-2 ìm) are not easily cleared in the neutral physiological environment and can have potential to continuously release drug from the injection sites in the spinal cord. The efficacy of calpain inhibitor-encapsulated PKMs were studied by evaluation the behavior and survival of SOD1G93A rats, a genetic rat model for ALS. We observed the trend toward improvements in grip strength and rotarod performance in the first two months from the AK-PKMs treated group, however, further improvements are needed to enhance their in vivo efficacy.
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Díaz, Gómez Nina Christin [Verfasser]. "Synthese von Derivaten des marinen Polyketids (+)-Tedanolid : Synthese von Pf-Myosin A Inhibitoren / Nina Christin Díaz Gómez." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover, 2011. http://d-nb.info/1011250071/34.

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Kumpfmüller, Jana [Verfasser]. "Heterologe Produktion des Polyketids 6-Desoxyerythronolid B und des nichtribosomalen Peptids Enniatin B in Bacillus subtilis / Jana Kumpfmüller." Greifswald : Universitätsbibliothek Greifswald, 2014. http://d-nb.info/1060773988/34.

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Krumbholz, Grit [Verfasser], and Jörg [Akademischer Betreuer] Hacker. "Untersuchungen zur Struktur, Regulation und Funktion des nichtribosomalen Peptid-Polyketids Colibactin aus E. coli / Grit Krumbholz. Betreuer: Jörg Hacker." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1014892112/34.

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Lofton, Megan Christina. "Development of a small molecule drug delivery vehicle for treatment of chronic pulmonary diseases." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24706.

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Rema, B. "Studies Of Moisture-induced Crosslinking in Some Novel Vinyl Ether-Maleic Anhydride Copolymers and Terpolymers And Synthesis And Characterization Of Hyperbranched Polyketals." Thesis, 1999. http://etd.iisc.ernet.in/handle/2005/1660.

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Liu, Lu-chun, and 劉律君. "Preparation of magnolol loaded polyketal microparticles and their biomedical applications." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/w7444v.

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碩士
國立臺灣科技大學
醫學工程研究所
100
Acute lung injury (ALI) is one of the leading causes of death in sepsis. Pro-inflammatory cytokines secreted by macrophages and consequently produced nitric oxide (NO) that play a major role in mediating acute lung injury. Magnolol has shown inhibitory effects on NO production in lipopolysaccharides (LPS)-activated macrophages, however, the poor solubility and the poor suspension properties of magnolol have hindered the success. Drug delivery systems that can target magnolol to macrophages have great clinical potential. Polyketals, a family of pH sensitive biodegradable polymers, have been used as drug delivery vehicles for the treatment of inflammatory diseases because they have excellent biocompatibility and do not generate inflammatory acid degradation products.Polyketal microparticles can be manipulated to the optimal sizes (1-5 μm) for pulmonary drug delivery by changing the preparation conditions. Microparticles formulated from polyketal copolymers should be suitable for treating acute lung injury because they rapidly hydrolyze and release magnolol in the phagolysosome of macrophages (pH 5.0), but remain stables at physiological conditions (pH 7.4). In this research, we successfully synthesized a polyketal copolymer with rapid hydrolysis rate, and used it to encapsulate magnolol. The results showed the particle size of magnolol-PKMs is 3.5 ± 0.417 μm and encapsulation efficiency of magnolol-PKMs is 85 ± 8.44 %. Also magnolol-PKMs exhibited a great aqueous dispensability and low cytotoxicity. The magnolol-PKMs also showed better inhibitory effects on NO production from LPS -activated RAW 264.7 cell when compared to free magnolol at same condition．
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Conference papers on the topic "Polyketals"

1

Liu, Lu-Chun, Chi-Sheng Lo, Kan-Sheng Shih, and Chen-Yu Kao. "Preparation and in vitro Release of Itraconazole from Polyketal Microparticles." In 14th Asia Pacific Confederation of Chemical Engineering Congress. Singapore: Research Publishing Services, 2012. http://dx.doi.org/10.3850/978-981-07-1445-1_442.

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Journal articles
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