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Journal articles on the topic 'Polyhydroxylated alkaloids'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Koskinen, Ari M. P., Oili A. Kallatsa, and Maija Nissinen. "Polyhydroxylated indolizidine alkaloids—synthesis of dideoxycastanospermine." Tetrahedron 65, no. 45 (November 2009): 9285–90. http://dx.doi.org/10.1016/j.tet.2009.09.017.

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2

Watson, Alison A., George W. J. Fleet, Naoki Asano, Russell J. Molyneux, and Robert J. Nash. "Polyhydroxylated alkaloids — natural occurrence and therapeutic applications." Phytochemistry 56, no. 3 (February 2001): 265–95. http://dx.doi.org/10.1016/s0031-9422(00)00451-9.

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3

Carretero, Juan C., Ramón Gómez Arrayás, and Isabel Storch de Gracia. "A stereoselective approach to polyhydroxylated quinolizidine alkaloids." Tetrahedron Letters 38, no. 49 (December 1997): 8537–40. http://dx.doi.org/10.1016/s0040-4039(97)10241-6.

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4

Shang, Qian, Junfeng Xiang, Hong Zhang, Qian Li, and Yalin Tang. "The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase." PLoS ONE 8, no. 8 (August 13, 2013): e70841. http://dx.doi.org/10.1371/journal.pone.0070841.

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5

Muroni, Daniele, Mauro Mucedda, and Antonio Saba. "Synthetic RCM approaches to enantiopure polyhydroxylated pyrrolizidine alkaloids." Tetrahedron Letters 49, no. 15 (April 2008): 2373–76. http://dx.doi.org/10.1016/j.tetlet.2008.02.071.

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6

Yamashita, Toru, Kayo Yasuda, Haruhisa Kizu, Yukihiko Kameda, Alison A. Watson, Robert J. Nash, George W. J. Fleet, and Naoki Asano. "New Polyhydroxylated Pyrrolidine, Piperidine, and Pyrrolizidine Alkaloids fromScillasibirica." Journal of Natural Products 65, no. 12 (December 2002): 1875–81. http://dx.doi.org/10.1021/np020296h.

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7

Pyne, Stephen G., Christopher W. G. Au, Andrew S. Davis, Ian R. Morgan, Thunwadee Ritthiwigrom, and Arife Yazici. "Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis." Pure and Applied Chemistry 80, no. 4 (January 1, 2008): 751–62. http://dx.doi.org/10.1351/pac200880040751.

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We have demonstrated that the borono-Mannich reaction is a versatile and efficient reaction for the diastereoselective preparation of chiral 1,2-amino alcohols. These Mannich products are valuable starting materials as shown in this report by the synthesis of bioactive polyhydroxylated pyrrolizidine and indolizidine alkaloids. Initial studies, directed at the more complex Stemona alkaloids and using the borono-Mannich reaction on cyclic N-acyliminium ions, are encouraging, as demonstrated by the synthesis of the pyrido[1,2-a]azepine core structure of stemocurtisinol.

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8

Eum, Heesung, Jihye Choi, Cheon-Gyu Cho, and Hyun-Joon Ha. "Regiochemistry-Directed Syntheses of Polyhydroxylated Alkaloids from Chiral Aziridines." Asian Journal of Organic Chemistry 4, no. 12 (September 14, 2015): 1399–409. http://dx.doi.org/10.1002/ajoc.201500285.

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9

Watson, Alison A., George W. J. Fleet, Naoki Asano, Russell J. Molyneux, and Robert J. Nash. "ChemInform Abstract: Polyhydroxylated Alkaloids - Natural Occurrence and Therapeutic Applications." ChemInform 32, no. 34 (May 25, 2010): no. http://dx.doi.org/10.1002/chin.200134269.

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10

CARRETERO, J. C., R. GOMEZ ARRAYAS, and I. STORCH DE GRACIA. "ChemInform Abstract: A Stereoselective Approach to Polyhydroxylated Quinolizidine Alkaloids." ChemInform 29, no. 9 (June 23, 2010): no. http://dx.doi.org/10.1002/chin.199809210.

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11

Yoda, Hidemi. "Recent Advances in the Synthesis of Naturally Occurring Polyhydroxylated Alkaloids." Current Organic Chemistry 6, no. 3 (March 1, 2002): 223–43. http://dx.doi.org/10.2174/1385272024605069.

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12

Bouillon, Marc E., and Stephen G. Pyne. "Diastereoselective concise syntheses of the polyhydroxylated alkaloids DMDP and DAB." Tetrahedron Letters 55, no. 2 (January 2014): 475–78. http://dx.doi.org/10.1016/j.tetlet.2013.11.068.

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13

Lopez, M., J. Cobo, and M. Nogueras. "Building Bicyclic Polyhydroxylated Alkaloids: An Overview from 1995 to the Present." Current Organic Chemistry 12, no. 9 (June 1, 2008): 718–50. http://dx.doi.org/10.2174/138527208784567197.

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14

Kusano, Genjiro, Makio Shibano, and Daisuke Tsukamoto. "Polyhydroxylated Alkaloids with Lipophilic Moieties as Glycosidase Inhibitors from Higher Plants." HETEROCYCLES 57, no. 8 (2002): 1539. http://dx.doi.org/10.3987/rev-02-551.

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15

Asano, Naoki, Makoto Nishida, Miwa Miyauchi, Kyoko Ikeda, Masaru Yamamoto, Haruhisa Kizu, Yukihiko Kameda, Alison A. Watson, Robert J. Nash, and George W. J. Fleet. "Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)." Phytochemistry 53, no. 3 (February 2000): 379–82. http://dx.doi.org/10.1016/s0031-9422(99)00555-5.

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16

Chang, Yi-Fan, Chih-Wei Guo, Ting-Hao Chan, Yi-Wen Pan, En-Lun Tsou, and Wei-Chieh Cheng. "Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids." Molecular Diversity 15, no. 1 (June 20, 2010): 203–14. http://dx.doi.org/10.1007/s11030-010-9255-4.

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17

Asano, Naoki, Toru Yamashita, Kayo Yasuda, Kyoko Ikeda, Haruhisa Kizu, Yukihiko Kameda, Atsushi Kato, Robert J. Nash, Heui Sam Lee, and Kang Sun Ryu. "Polyhydroxylated Alkaloids Isolated from Mulberry Trees (Morus albaL.) and Silkworms (Bombyx moriL.)." Journal of Agricultural and Food Chemistry 49, no. 9 (September 2001): 4208–13. http://dx.doi.org/10.1021/jf010567e.

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18

Asano, Naoki, Hiroyo Kuroi, Kyoko Ikeda, Haruhisa Kizu, Yukihiko Kameda, Atsushi Kato, Isao Adachi, Alison A. Watson, Robert J. Nash, and George W. J. Fleet. "New polyhydroxylated pyrrolizidine alkaloids from Muscari armeniacum: structural determination and biological activity." Tetrahedron: Asymmetry 11, no. 1 (January 2000): 1–8. http://dx.doi.org/10.1016/s0957-4166(99)00508-x.

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19

Kato, Atsushi, Isao Adachi, Miwa Miyauchi, Kyoko Ikeda, Tomomi Komae, Haruhisa Kizu, Yukihiko Kameda, et al. "Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata." Carbohydrate Research 316, no. 1-4 (March 1999): 95–103. http://dx.doi.org/10.1016/s0008-6215(99)00043-9.

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20

Zhang, Ning, Yafeng Li, Yueming Zhou, Jian Hou, Qing He, Xiang-Guo Hu, Yue-Mei Jia, Chu-Yi Yu, and Zongxiu Nie. "Rapid detection of polyhydroxylated alkaloids in mulberry using leaf spray mass spectrometry." Analytical Methods 5, no. 10 (2013): 2455. http://dx.doi.org/10.1039/c3ay00018d.

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21

Yoda, Hidemi. "ChemInform Abstract: Recent Advances in the Synthesis of Naturally Occurring Polyhydroxylated Alkaloids." ChemInform 33, no. 50 (May 18, 2010): no. http://dx.doi.org/10.1002/chin.200250256.

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22

Carroll, Anthony W., and Stephen G. Pyne. "The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis." Current Organic Synthesis 16, no. 4 (July 4, 2019): 498–522. http://dx.doi.org/10.2174/1570179416666190126100312.

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Background: The inherent glycosidase inhibitory activity and potentially therapeutic value of the polyhydroxylated pyrrolizidine alkaloids containing a hydroxymethyl substituent at the C-3 position have been well documented. Belonging to this class, the naturally occurring hyacinthacine C-type alkaloids are of general interest among iminosugar researchers. Their selective micromolar α -glycosidase inhibitory ranges (10 – 100 μM) suggest that these azasugars are potential leads for treating type II diabetes. However, the structures of hyacinthacine C1, C3 and C4 are insecure with hyacinthacine C5 being recently corrected. Objective: This review presents the hyacinthacine C-type alkaloids: their first discovery to the most recent advancements on the structures, biological activities and total synthesis. Conclusion: The hyacinthacine C-type alkaloids are of exponentially increasing interest and will undoubtedly continue to be reported as synthetic targets. They represent a challenging but rewarding synthetic feat for the community of those interested in accessing biologically active iminosugars. Since 2009, ten total syntheses have been employed towards accessing similarly related products but only three have assessed the glycosidase inhibitory activity of the final products. This suggests the need for an accessible and universal glycosidase inhibitory assay so to accurately determine the structure-activity relationship of how the hyacinthacine C-type alkaloids inhibit specific glycosidases. Confirming the correct structures of the hyacinthacine C-type alkaloids as well as accessing various analogues continues to strengthen the foundation towards a marketable treatment for type II diabetes and other glycosidase related illnesses.

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23

Koskinen, Ari M. P., and Oili A. Kallatsa. "Polyhydroxylated indolizidine alkaloids—an efficient synthesis of 1-deoxy-8,8a-di-epi-castanospermine." Tetrahedron 59, no. 35 (August 2003): 6947–54. http://dx.doi.org/10.1016/s0040-4020(03)00918-9.

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24

Shibano, Makio, Daisuke Tsukamoto, and Genjiro Kusano. "ChemInform Abstract: Polyhydroxylated Alkaloids with Lipophilic Moieties as Glycosidase Inhibitors from Higher Plants." ChemInform 33, no. 42 (May 19, 2010): no. http://dx.doi.org/10.1002/chin.200242280.

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25

Asano, Naoki, Makoto Nishida, Miwa Miyauchi, Kyoko Ikeda, Masaru Yamanoto, Haruhisa Kizu, Yukihiko Kameda, Alison A. Watson, Robert J. Nash, and Gerorge W. J. Fleet. "ChemInform Abstract: Polyhydroxylated Pyrrolidine and Piperidine Alkaloids from Adenophora triphylla var. japonica (Campanulaceae)." ChemInform 31, no. 20 (June 8, 2010): no. http://dx.doi.org/10.1002/chin.200020181.

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26

Sanap, Shrihari P., Sougata Ghosh, Amit M. Jabgunde, Rahul V. Pinjari, Shridhar P. Gejji, Shailza Singh, Balu A. Chopade, and Dilip D. Dhavale. "Synthesis, computational study and glycosidase inhibitory activity of polyhydroxylated conidine alkaloids—a bicyclic iminosugar." Organic & Biomolecular Chemistry 8, no. 14 (2010): 3307. http://dx.doi.org/10.1039/c004690f.

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27

Asano, Naoki, Hiroyo Kuroi, Kyoko Ikeda, Haruhisa Kizu, Yukihiko Kameda, Atsushi Kato, Isao Adachi, Alison A. Watson, Robert J. Nash, and George W. J. Fleet. "ChemInform Abstract: New Polyhydroxylated Pyrrolizidine Alkaloids from Muscari armeniacum: Structural Determination and Biological Activity." ChemInform 31, no. 24 (June 8, 2010): no. http://dx.doi.org/10.1002/chin.200024211.

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28

Zheng, Xiao, WenFang Zhu, and PeiQiang Huang. "Concise synthesis of two advanced intermediates for the asymmetric synthesis of polyhydroxylated indolizidine alkaloids." Science China Chemistry 53, no. 9 (September 2010): 1914–20. http://dx.doi.org/10.1007/s11426-010-4065-1.

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29

Asano, Naoki, and et al et al. "ChemInform Abstract: Polyhydroxylated Pyrrolidine and Pyrrolizidine Alkaloids from Hyacinthoides non-scripta and Scilla campanulata." ChemInform 30, no. 42 (June 13, 2010): no. http://dx.doi.org/10.1002/chin.199942229.

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30

Kazmaier, Uli. "ChemInform Abstract: Synthesis of Polyhydroxylated Piperidine Alkaloids via Reactions of Chelated Amino Acid Ester Enolates." ChemInform 30, no. 50 (June 12, 2010): no. http://dx.doi.org/10.1002/chin.199950280.

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31

Delso, Ignacio, Tomás Tejero, Andrea Goti, and Pedro Merino. "Synthesis of d-arabinose-derived polyhydroxylated pyrrolidine, indolizidine and pyrrolizidine alkaloids. Total synthesis of hyacinthacine A2." Tetrahedron 66, no. 6 (February 2010): 1220–27. http://dx.doi.org/10.1016/j.tet.2009.12.030.

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32

Dhavale, Dilip D., K. S. Ajish Kumar, Vinod D. Chaudhari, Tarun Sharma, Sushma G. Sabharwal, and J. PrakashaReddy. "Aziridine carboxylate from d-glucose: synthesis of polyhydroxylated piperidine, pyrrolidine alkaloids and study of their glycosidase inhibition." Organic & Biomolecular Chemistry 3, no. 20 (2005): 3720. http://dx.doi.org/10.1039/b509216g.

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33

White, James D., and Peter Hrnciar. "Synthesis of Polyhydroxylated Pyrrolizidine Alkaloids of the Alexine Family by Tandem Ring-Closing Metathesis−Transannular Cyclization. (+)-Australine." Journal of Organic Chemistry 65, no. 26 (December 2000): 9129–42. http://dx.doi.org/10.1021/jo0012748.

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34

Eum, Heesung, Jihye Choi, Cheon-Gyu Cho, and Hyun-Joon Ha. "Cover Picture: Regiochemistry-Directed Syntheses of Polyhydroxylated Alkaloids from Chiral Aziridines (Asian J. Org. Chem. 12/2015)." Asian Journal of Organic Chemistry 4, no. 12 (November 16, 2015): 1325. http://dx.doi.org/10.1002/ajoc.201500380.

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35

Wei, Helin, Siyuan Liu, Yijun Liao, Chuanhui Ma, Dongying Wang, Jiayun Tong, Jiafu Feng, Tao Yi, and Lin Zhu. "A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus." American Journal of Chinese Medicine 46, no. 08 (January 2018): 1743–70. http://dx.doi.org/10.1142/s0192415x1850088x.

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Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have played a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhydroxylated alkaloids, flavonoids and polysaccharides from mulberry may be the potential active components. The present review systematically summarizes the chemical composition of mulberry and the pharmacological effects of different medicinal parts on DM; these effects include influences on glucose absorption, insulin (INS) production/secretion, anti-oxidation and anti-inflammation processes. After summarizing our research findings, we will discuss the challenges and opportunities and explore the direction of future research and the potential for developing mulberry into pharmaceuticals for the widespread treatment of DM.

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36

Bande, Omprakash P., Vrushali H. Jadhav, Vedavati G. Puranik, and Dilip D. Dhavale. "1,3-Dipolar cycloaddition reaction of a d-galactose derived nitrone with allyl alcohol: synthesis of polyhydroxylated perhydroazaazulene alkaloids." Tetrahedron: Asymmetry 18, no. 10 (June 2007): 1176–82. http://dx.doi.org/10.1016/j.tetasy.2007.05.012.

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37

Ji, Tao, Jun Li, Shu-Lan Su, Zhen-Hua Zhu, Sheng Guo, Da-Wei Qian, and Jin-Ao Duan. "Identification and Determination of the Polyhydroxylated Alkaloids Compounds with α-Glucosidase Inhibitor Activity in Mulberry Leaves of Different Origins." Molecules 21, no. 2 (February 8, 2016): 206. http://dx.doi.org/10.3390/molecules21020206.

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38

Zeng, Jing, Qian Zhang, Hong-Kui Zhang, and Anqi Chen. "Practical synthesis of trans-dihydroxybutyrolactols as chiral C4 building blocks and their application to the synthesis of polyhydroxylated alkaloids." RSC Advances 3, no. 43 (2013): 20298. http://dx.doi.org/10.1039/c3ra43232g.

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39

Pearson, William H., and Erik J. Hembre. "Synthesis of Novel Glycosidase-Inhibitory Hydroxymethyl-Substituted Polyhydroxylated Indolizidines: Ring-Expanded Analogs of the Pyrrolizidine Alkaloids Alexine and Australine." Journal of Organic Chemistry 61, no. 16 (January 1996): 5546–56. http://dx.doi.org/10.1021/jo960610a.

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40

Cahours, X., Y. Daali, S. Cherkaoui, and J. L. Veuthey. "Simultaneous analysis of polyhydroxylated alkaloids by capillary electrophoresis using borate complexation and evaluation of sweeping technique for sensitivity improvement." Chromatographia 55, no. 3-4 (February 2002): 211–16. http://dx.doi.org/10.1007/bf02492144.

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41

White, James D., and Peter Hrnciar. "ChemInform Abstract: Synthesis of Polyhydroxylated Pyrrolizidine Alkaloids of the Alexine Family by Tandem Ring-Closing Metathesis-Transannular Cyclization. (+)-Australine." ChemInform 32, no. 19 (May 8, 2001): no. http://dx.doi.org/10.1002/chin.200119180.

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42

Peralta-Hernández, Eduardo, Omar Cortezano-Arellano, and Alejandro Cordero-Vargas. "A practical one-pot radical-ionic sequence for the preparation of epoxides: application to the synthesis of unnatural polyhydroxylated alkaloids." Tetrahedron Letters 52, no. 51 (December 2011): 6899–902. http://dx.doi.org/10.1016/j.tetlet.2011.10.042.

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43

PEARSON, W. H., and E. J. HEMBRE. "ChemInform Abstract: Synthesis of Novel Glycosidase-Inhibitory Hydroxymethyl-Substituted Polyhydroxylated Indolizidines: Ring-Expanded Analogues of the Pyrrolizidine Alkaloids Alexine and Australine." ChemInform 28, no. 2 (August 4, 2010): no. http://dx.doi.org/10.1002/chin.199702125.

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44

Peralta-Hernandez, Eduardo, Omar Cortezano-Arellano, and Vargas Alejandro Cordero. "ChemInform Abstract: A Practical One-Pot Radical-Ionic Sequence for the Preparation of Epoxides: Application to the Synthesis of Unnatural Polyhydroxylated Alkaloids." ChemInform 43, no. 14 (March 8, 2012): no. http://dx.doi.org/10.1002/chin.201214092.

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45

Chen, Ming-Jen, and Yeun-Min Tsai. "Intramolecular α-acylamino radical cyclizations with acylsilanes in the preparation of polyhydroxylated alkaloids: (+)-lentiginosine, (+)-1,8a-di-epi-lentiginosine, and (+)-1,2-di-epi-swainsonine." Tetrahedron Letters 48, no. 36 (September 2007): 6271–74. http://dx.doi.org/10.1016/j.tetlet.2007.07.021.

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46

Brock, E. Anne, Stephen G. Davies, James A. Lee, Paul M. Roberts, and James E. Thomson. "Polyhydroxylated pyrrolizidine alkaloids from transannular iodoaminations: application to the asymmetric syntheses of (−)-hyacinthacine A1, (−)-7a-epi-hyacinthacine A1, (−)-hyacinthacine A2, and (−)-1-epi-alexine." Organic & Biomolecular Chemistry 11, no. 19 (2013): 3187. http://dx.doi.org/10.1039/c3ob40205c.

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47

Bokov, Dmitry Olegovich. "MUSCARI ARMENIACUM LEICHTLIN (GRAPE HYACINTH): PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES REVIEW." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (January 7, 2019): 68. http://dx.doi.org/10.22159/ajpcr.2018.v12i1.30325.

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This review focuses on the Muscari armeniacum Leichtlin (Asparagaceae Juss) biologically active substances composition presented in the Aireal and underground parts and finding their possible therapeutic effects. The systematic review is dedicated to the composition of biologically active substances, including recent advances in the biological activity investigation, phytochemical studies, and biotechnology methods of plant material producing. Various electronic search engines such as Google, Google Scholar, scientific literature, publishing sites, and electronic databases such as PubMed, Wiley, Springer, and Science Direct had been searched and data obtained. Other online academic libraries such as E-library and specific ethnopharmacological literature had been searched systematically for more exhaustive information on the crude herbal drug. The chemical composition of M. armeniacum biologically active substances is established; it contains anthocyanins (delphinidin and cyanidin derivatives), homoisoflavonoids, polyhydroxylated pyrrolizidine alkaloids (hyacinthacines A1, A2, A3, and B3), oligoglycosides (Muscarosides), and ribosome-inactivating proteins (musarmins). Recent physicochemical analytical procedures for components determination and hyacinthacines synthesis pathways are mentioned. Moreover, future prospects and trends in the research of this plant have been proposed. We have reviewed researches conducted on M. armeniacum especially in areas of its use in medicine, phytochemicals, biological activity, and developed analytical methods. M. armeniacum possesses antioxidant, antimutagenic activity, and specific glycosidase inhibitory activity; M. armeniacum can be used for the production of potential anticancer, antiviral, antidiabetic, and anti-obesity drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for giving further information on the clinical practice and standardization procedures for the crude herbal drug.

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48

Bokov, Dmitry Olegovich. "MUSCARI ARMENIACUM LEICHTLIN (GRAPE HYACINTH): PHYTOCHEMISTRY AND BIOLOGICAL ACTIVITIES REVIEW." Asian Journal of Pharmaceutical and Clinical Research 12, no. 1 (January 7, 2019): 68. http://dx.doi.org/10.22159/ajpcr.2019.v12i1.30325.

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Abstract:

This review focuses on the Muscari armeniacum Leichtlin (Asparagaceae Juss) biologically active substances composition presented in the Aireal and underground parts and finding their possible therapeutic effects. The systematic review is dedicated to the composition of biologically active substances, including recent advances in the biological activity investigation, phytochemical studies, and biotechnology methods of plant material producing. Various electronic search engines such as Google, Google Scholar, scientific literature, publishing sites, and electronic databases such as PubMed, Wiley, Springer, and Science Direct had been searched and data obtained. Other online academic libraries such as E-library and specific ethnopharmacological literature had been searched systematically for more exhaustive information on the crude herbal drug. The chemical composition of M. armeniacum biologically active substances is established; it contains anthocyanins (delphinidin and cyanidin derivatives), homoisoflavonoids, polyhydroxylated pyrrolizidine alkaloids (hyacinthacines A1, A2, A3, and B3), oligoglycosides (Muscarosides), and ribosome-inactivating proteins (musarmins). Recent physicochemical analytical procedures for components determination and hyacinthacines synthesis pathways are mentioned. Moreover, future prospects and trends in the research of this plant have been proposed. We have reviewed researches conducted on M. armeniacum especially in areas of its use in medicine, phytochemicals, biological activity, and developed analytical methods. M. armeniacum possesses antioxidant, antimutagenic activity, and specific glycosidase inhibitory activity; M. armeniacum can be used for the production of potential anticancer, antiviral, antidiabetic, and anti-obesity drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for giving further information on the clinical practice and standardization procedures for the crude herbal drug.

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49

Wang, Niannian, Feifei Zhu, and Keping Chen. "1-Deoxynojirimycin: Sources, Extraction, Analysis and Biological Functions." Natural Product Communications 12, no. 9 (September 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200934.

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1-Deoxynojirimycin (DNJ), a natural polyhydroxylated piperidine alkaloid, is attracting growing attention due to its important biological functions. This paper introduces the discovery and origins of DNJ, its extraction, purification, and physiological functions in the treatment of diabetes. The mechanisms of DNJ in the inhibition of fat accumulation and tumor cell metastasis are also discussed. In addition, the prospects and challenges of DNJ for practical production are proposed. This work aims to provide technical advice on obtaining DNJ and a fuller understanding of its biological activities.

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50

Dumbre, Shrinivas, and Sujit Pal. "Synthesis of Polyhydroxylated Conidine Alkaloid as a Conformationally Restricted Azasugar." Synlett 27, no. 20 (September 6, 2016): 2799–802. http://dx.doi.org/10.1055/s-0036-1588312.

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