Relevant bibliographies by topics / Polyhydroxylated alkaloids

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  2. Dissertations / Theses
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Academic literature on the topic 'Polyhydroxylated alkaloids'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 January 2023

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Journal articles on the topic "Polyhydroxylated alkaloids"

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Koskinen, Ari M. P., Oili A. Kallatsa, and Maija Nissinen. "Polyhydroxylated indolizidine alkaloids—synthesis of dideoxycastanospermine." Tetrahedron 65, no. 45 (November 2009): 9285–90. http://dx.doi.org/10.1016/j.tet.2009.09.017.

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Watson, Alison A., George W. J. Fleet, Naoki Asano, Russell J. Molyneux, and Robert J. Nash. "Polyhydroxylated alkaloids — natural occurrence and therapeutic applications." Phytochemistry 56, no. 3 (February 2001): 265–95. http://dx.doi.org/10.1016/s0031-9422(00)00451-9.

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Carretero, Juan C., Ramón Gómez Arrayás, and Isabel Storch de Gracia. "A stereoselective approach to polyhydroxylated quinolizidine alkaloids." Tetrahedron Letters 38, no. 49 (December 1997): 8537–40. http://dx.doi.org/10.1016/s0040-4039(97)10241-6.

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4

Shang, Qian, Junfeng Xiang, Hong Zhang, Qian Li, and Yalin Tang. "The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase." PLoS ONE 8, no. 8 (August 13, 2013): e70841. http://dx.doi.org/10.1371/journal.pone.0070841.

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Muroni, Daniele, Mauro Mucedda, and Antonio Saba. "Synthetic RCM approaches to enantiopure polyhydroxylated pyrrolizidine alkaloids." Tetrahedron Letters 49, no. 15 (April 2008): 2373–76. http://dx.doi.org/10.1016/j.tetlet.2008.02.071.

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Yamashita, Toru, Kayo Yasuda, Haruhisa Kizu, Yukihiko Kameda, Alison A. Watson, Robert J. Nash, George W. J. Fleet, and Naoki Asano. "New Polyhydroxylated Pyrrolidine, Piperidine, and Pyrrolizidine Alkaloids fromScillasibirica." Journal of Natural Products 65, no. 12 (December 2002): 1875–81. http://dx.doi.org/10.1021/np020296h.

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Pyne, Stephen G., Christopher W. G. Au, Andrew S. Davis, Ian R. Morgan, Thunwadee Ritthiwigrom, and Arife Yazici. "Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis." Pure and Applied Chemistry 80, no. 4 (January 1, 2008): 751–62. http://dx.doi.org/10.1351/pac200880040751.

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We have demonstrated that the borono-Mannich reaction is a versatile and efficient reaction for the diastereoselective preparation of chiral 1,2-amino alcohols. These Mannich products are valuable starting materials as shown in this report by the synthesis of bioactive polyhydroxylated pyrrolizidine and indolizidine alkaloids. Initial studies, directed at the more complex Stemona alkaloids and using the borono-Mannich reaction on cyclic N-acyliminium ions, are encouraging, as demonstrated by the synthesis of the pyrido[1,2-a]azepine core structure of stemocurtisinol.
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Eum, Heesung, Jihye Choi, Cheon-Gyu Cho, and Hyun-Joon Ha. "Regiochemistry-Directed Syntheses of Polyhydroxylated Alkaloids from Chiral Aziridines." Asian Journal of Organic Chemistry 4, no. 12 (September 14, 2015): 1399–409. http://dx.doi.org/10.1002/ajoc.201500285.

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Watson, Alison A., George W. J. Fleet, Naoki Asano, Russell J. Molyneux, and Robert J. Nash. "ChemInform Abstract: Polyhydroxylated Alkaloids - Natural Occurrence and Therapeutic Applications." ChemInform 32, no. 34 (May 25, 2010): no. http://dx.doi.org/10.1002/chin.200134269.

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CARRETERO, J. C., R. GOMEZ ARRAYAS, and I. STORCH DE GRACIA. "ChemInform Abstract: A Stereoselective Approach to Polyhydroxylated Quinolizidine Alkaloids." ChemInform 29, no. 9 (June 23, 2010): no. http://dx.doi.org/10.1002/chin.199809210.

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Dissertations / Theses on the topic "Polyhydroxylated alkaloids"

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Rudge, Andrew John. "The synthesis of polyhydroxylated alkaloids." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272797.

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Tang, Minyan. "The asymmetric synthesis of polyhydroxylated pyrrolizidine alkaloids." Department of Chemistry - Faculty of Science, 2004. http://ro.uow.edu.au/theses/233.

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Chapter 1 of this thesis is a review of the literature on the structure, biological activities and synthesis of polyhydroxylated 3-hydroxymethylpyrrolizidine alkaloids. This Chapter also outlines he aims of this project, which were to develop a flexible synthesis of the 1,2,7-trihydroxy-3-hydroxymethylpyrroizidine alkaloid australine, and its epimers. Chapter 2 describes model synthetic chemical studies on the synthesis of the pyrrolizidine core structure. The key synthetic steps, the aminolysis reaction of vinyl expoxides with ally1 amine, the ring-closing metathesis of the resulting diene, syndihydroxylation of the 2,5-dihydropyrrole product and finally ring closure to give the pyrrolizidine nucleus were successfully developed. Chapter 3 describes the application of the chemistry developed in Chapter 2 to the diastereoselective synthesis of the 3-hydroxymethy1-2,3,5,6,7,7 a-hexahydro-1H-pyrrolizine-1,2,7-triol structure, characteristic of several pyrrolizidine natural products. Two unnatural pyrrolizidine alkaloids, (-)-7-espiaustraline and (+)-1,7-diepiaustraline were successfully synthesized. The oxazolidinone group was found to be a useful protecting group in the RCM reaction and, as part of a pyrrolo[1,2-c]oxazol-3-one ring system, functioned as a stereo- and regio-directing group, in a key diastereoselective syn-dihydroxylation reaction and a regioselective nucleophilic ring-opening of a S,S-dioxo-dioxathiole. Chapter 4 describes the asymmetric synthesis of the pyrrolizidine alkaloid, (+)-1-epiaustraline. Attempts to extend this methodology to the synthesis of australine were not successful since the final pyrrolidine ring closure to produce the desired pyrrolizine was not productive.
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Morewood, Karen Margaret. "Studies towards the synthesis of polyhydroxylated alkaloids." Thesis, Loughborough University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421748.

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Collins, Ian James. "Studies towards the synthesis of polyhydroxylated indolizidines." Thesis, University of Cambridge, 1991. https://www.repository.cam.ac.uk/handle/1810/272578.

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Ramsden, Nigel G. "Some asymmetric syntheses." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258255.

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Farrant, Elizabeth. "A novel approach to the synthesis of polyhydroxylated indolizidine alkaloids." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360718.

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Legrave, Nathalie. "Identification, synthèse et valorisation de molécules bioactives d’invertébrés marins de Nouvelle Calédonie et de Méditerranée." Thesis, Nice, 2013. http://www.theses.fr/2013NICE4124.

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Ce manuscrit présente nos travaux de recherches réalisés sur : i) des éponges marines de Méditerranée (Phorbas tenacior) et des DOM-TOM (Niphates sp. et Clathria rugosa), sélectionnées sur la base des propriétés biologiques préliminaires réalisées sur les extraits bruts, de l’originalité des métabolites, et/ou de l’absence d’étude chimique antérieure de l’espèce ; ii) la synthèse et l’évaluation des propriétés biocides d’analogues de la viscosaline, molécule de type 3-alkylpyridinium aux propriétés antibactériennes et antisalissures faiblement valorisées. L’étude de l’éponge calédonienne Niphates sp. a conduit à l’isolement des népheliosynes A et B, deux polyacétylènes polyhydroxylés avec des cytotoxicités modérées. Les anchinopeptolides B-D, inhibiteurs sélectifs des kinases GSK-3 et PfGSK-3, ont été isolés de Phorbas tenacior, ainsi que la phorbasoïne, un alcaloïde nouveau avec un coeur hydantoïne. Enfin, la première étude chimique de Clathria rugosa a conduit à l’isolement d’un nouveau macrolide, le Clathriolide, un métabolite secondaire cytotoxique vis-à-vis de nombreuses lignées cellulaires tumorales. Chacun des métabolites isolés a fait l’objet d’une étude structurale et biologique poussée. Une stratégie de synthèse originale d’analogues structuraux de la viscosaline a été mise au point. Les dérivés obtenus possèdent d’excellentes activités antibactériennes et antisalissures ainsi que des activités antitumorales modérées
This manuscript deals with : i) marine sponges from the Mediterranean Sea (Phorbas tenacior) and New Caledonia (Niphates sp. and Clathria rugosa), selected for their biological activities conduced on their crude extract, the originality of produced secondary metabolites and the absence of previous chemical studies ii) the synthesis and the antibacterial properties of analogues of viscosaline. Viscosaline is a 3-alkylpyridinium secondary metabolites which exhibited interesting antibacterial and antifouling properties. The study of the New Caledonian marine sponge Niphates sp. led to the isolation of nepheliosynes Aand B, two polyhydroxylated polyacetylenic acids which exhibited moderate cytotoxic properties. The anchinopeptolides B-D, selective inhibitors of GSK-3 and PfGSK-3 kinases, have been isolated from Phorbas tenacior along with the new alkaloid phorbasoïne. Finally, the first study of the New Caledonian sponge Clathria rugosa let to the isolation of new macrolide, clathriolide, which exhibited cytotoxic properties. The structures and biological properties of each metabolite have been extensively studied in this work. An original synthesis of analogues of viscosaline had been developed. All the derivatives showed excellent antibacterial and antifouling properties, and moderate antitumoral activities
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Yao-Ting, Yeh, and 葉耀廷. "Chiral Cyclic Nitrone Chemistry: Preparation of Polyhydroxylated Pyrrolidine and Piperidine Alkaloids." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/61660957671733400891.

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碩士
國立臺灣師範大學
化學系
96
The chiral polyhydroxy alkaloids have attracted considerable attention in organic synthesis owing to their remarkable biological properties and their potential as pharmaceuticals, especially, to serve as glycosidase inhibitors in treatment of cancers, diabetes and viral infections. The development of new methods for the synthesis of pyrrolidine- or piperidine-based compounds is therefore of considerable importance, particularly for the approaches leading to chiral derivatives of these ring skeletons. In this thesis, we have developed new and efficient synthetic protocols to prepare various polyhydroxylated pyrrolidine and piperidine-based alkaloids from D-xylose to evaluate their biological activities.
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Hrnciar, Peter. "Synthetic studies on alkaloids : part I; asymmetric synthesis of (��) codeine. Formal synthesis of (��) morphine : part II; a unified asymetric approach toward synthesis of polyhydroxylated pyrrolizidine alkaloids, australine and alexine." Thesis, 1998. http://hdl.handle.net/1957/33295.

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Books on the topic "Polyhydroxylated alkaloids"

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Hrnciar, Peter. Synthetic studies on alkaloids: Part I; asymmetric synthesis of (±) codeine. Formal synthesis of (±) morphine : part II; a unified asymetric approach toward synthesis of polyhydroxylated pyrrolizidine alkaloids, australine and alexine. 1998.

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Book chapters on the topic "Polyhydroxylated alkaloids"

1

Nash, Robert J., Alison A. Watson, and Naoki Asano. "Chapter Five Polyhydroxylated alkaloids that inhibit glycosidases." In Alkaloids: Chemical and Biological Perspectives, 345–76. Elsevier, 1996. http://dx.doi.org/10.1016/s0735-8210(96)80009-4.

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