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Diz, Harry R., and Jason Murnock. "Distribution of Arsenic in Presque Isle State Park Pond Sediments." Journal of the Pennsylvania Academy of Science 87, no. 3 (December 1, 2013): 134–44. http://dx.doi.org/10.5325/jpennacadscie.87.3.0134.
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ABSTRACT A study of arsenic in pond sediments on the Presque Isle peninsula, Erie, PA, was conducted in 2000 and 2001 by Murnoch (2002) due to concerns expressed by citizens and various local officials. Samples of pond and lagoon sediments were collected at thirteen primary sites and additional reference sites for analysis of arsenic content during the fall, 2000, and again in spring, 2001. The probable effect concentration (PEC) for arsenic of 33.0 mg/kg-DW, an indication of the concentration above which adverse impacts on benthic organisms are expected to occur, was exceeded in the surface sediments at all 13 primary sites during fall sampling and in all but one site during spring sampling, with concentrations as high as 393 mg/kg-DW measured. For deeper sediments, the PEC was exceeded in the fall at nine sites and in the spring at six sites. Surface sediments contained more arsenic than did deeper sediments. These differences were more pronounced in the spring samples than in the fall samples. There was a general trend, with numerous exceptions, for sites closer to Gull Point (the geologically ‘new’ end of the peninsula) to have lower arsenic levels. While the source of the arsenic in the sediments of Presque Isle is unknown, these high levels are likely due to natural processes that, over time, have resulted in an enrichment of arsenic in surface sediments. A possible mechanism for this enrichment is proposed. This study has not attempted to document the risk to the ecosystem associated with elevated arsenic concentrations, but it is reasonable to speculate that there could be an adverse impact on some organisms.
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Chorba, Carrie C. "James Mandrell, Don Juan and the point of honor: Seduction, patriarchal society, and literary tradition. Pennsylvania State University Press, University Park, PA, 1992; 310 pp." Nueva Revista de Filología Hispánica (NRFH) 44, no. 1 (January 1, 1996): 222–26. http://dx.doi.org/10.24201/nrfh.v44i1.1924.
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Classen, Albrecht. "Robert the Devil: The First Modern English Translation of Robert le Diable, an Anonymous French Romance of the Thirteenth Century. Prepared by Samuel N. Rosenberg. University Park, PA: The Pennsylvania State University Press, 2018, 157 pp., 1 frontispiece." Mediaevistik 31, no. 1 (January 1, 2018): 477–78. http://dx.doi.org/10.3726/med012018_477.
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Quite commonly, medieval poets deal with a royal couple that seems to be infertile, when suddenly the wife becomes pregnant after all. But where and when would the devil be the one who creates this miracle after the poor queen has appealed to him, having turned despondent over God’s unwillingness to listen to her prayers? Even in the Middle English Sir Gowther (late 15th century), the future mother does not know that the devil takes on the shape of her husband in order to sleep with her, while in the Old French text, Robert le Diable, the poor woman even prays to the devil to help her. It also seems rather unusual that the poet then describes the child as virtually possessed by the devil, demonstrating egregiously aggressive behavior toward everyone, until at one point the protagonist learns from his mother the truth about his origin and immediately tries to atone for his evil deeds and turns into a most curious fool, obeying God’s command that he no longer speak and act like an utter madman, taking food only from a dog’s mouth.
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Lambert, Rodney K., Peter D. Paré, and Mitsushi Okazawa. "Stiffness of peripheral airway folding membrane in rabbits." Journal of Applied Physiology 90, no. 6 (June 1, 2001): 2041–47. http://dx.doi.org/10.1152/jappl.2001.90.6.2041.
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We have observed that small, membranous bronchioles from rabbits, in which the smooth muscle is not activated, experience a critical elastic buckling involving the whole airway wall during deflation of the lung. This implies that, at some point during the deflation, the airway wall goes from being in a state of tension to a state of compression. At the transition, there is neither net tension nor net compression in the wall, and the transmural pressure difference must, therefore, be zero. Thus at this point, the pressure difference across the muscle that results from the passive stress in the muscle is just balanced by the pressure difference across the folded mucosal membrane. We estimated the muscle stress, and hence the pressure across the muscle, from published data on rabbit trachealis (Opazo-Saez A and Paré PD, J Appl Physiol 77: 1638–1643, 1994) and equated this to the pressure across the folded membrane. By using a theoretical prediction of this pressure (Lambert RK, Codd SL, Alley MR, and Pack RJ, J Appl Physiol 77: 1206–1216, 1994), together with the results of our morphometric measurements on these airways, we estimated that the flexural rigidity of the folding membrane in peripheral rabbit airways is of the order of 10−12 Pa · m3. This value implies that, in these airways, membrane folding provides significant resistance to airway smooth muscle shortening.
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Wright, Samuel J., Minae An, Byung Hoon Min, You Jeong Heo, Milan Parikh, Lynn Bi, Hyuk Lee, et al. "Abstract 6846: Tumor cell metaplastic programs and failure of T cell remodeling drive resistance and progression to frontline chemoimmunotherapy in advanced gastric cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 6846. http://dx.doi.org/10.1158/1538-7445.am2024-6846.
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Abstract Adding aPD1 to 5-FU/platinum in advanced gastroesophageal adenocarcinomas (GEA) has yielded modest and heterogeneous results. Understanding cooperativity between these two treatment modalities will inform novel combination treatments for GEA. Towards this end, we conducted a trial (n = 47) sequentially adding pembrolizumab to 5-FU/platinum in previously untreated advanced GEA. Using serial biopsy of the primary tumor at baseline, after one cycle of 5-FU/platinum, and after the addition of pembrolizumab we transcriptionally profiled 358,067 single cells and obtained TCR-sequences from single tumor-resident T cells. Stratifying patients into slow- (> 6 months) and fast-progressing (< 6 months) groups based on progression-free survival allowed us to quantify differences in immune, stromal and epithelial subpopulations across treatment time points. Using topic modeling with consensus non-negative matrix factorization (cNMF), we identified gene expression programs in each population at each time point and developed a methodology to verify the stability of those programs across the cohort using cross-validation. Faster clinical progression featured decreased M1-like macrophage repolarization and increased MUC5A and MSLN containing metaplasia programs in tumor cells. We next selected features from cell state gene programs and identified trajectories of tumor cells across a spectrum of treatment sensitive and resistant states. We identified several factors that correlated with these trajectories and regulons that may be influencing them. After pembrolizumab we observed slower progression was associated with further increased CD8 T cell infiltration with increased CXCL13+ T cells. We next calculated covarying programs between patient samples at each time point and performed permutation testing to identify which programs (and respective cell types they were expressed in) were significantly correlated to infer the presence of multicellular tumor communities. We found that the tumor cell interferon program co-varied with the CXCL13 T cell program, and the emergence of a covarying module with tumor-reactive CXCL13 program expression happens as early as after the first dose of chemotherapy. To better understand the behavior of tumor reactive T cells within the tumor microenvironment, we leveraged TCR-sequencing data to study T cell clonality and diversity across treatment time points and between fast and slow progressors. Our data provide an invaluable resource to dissect chemoimmunotherapy response in tumor cells, understand T cell behavior and propose strategies to drive anti-tumor immune hub formation to expand the portion of patients benefiting from immunotherapy approaches. Citation Format: Samuel J. Wright, Minae An, Byung Hoon Min, You Jeong Heo, Milan Parikh, Lynn Bi, Hyuk Lee, Taejun Kim, Song-Yi Lee, Jeonghyeon Moon, Ryan J. Park, Matthew R. Strickland, Woong Yang Park, Won Ki Kang, Kyoung-Mee Kim, Seung Tae Kim, Arnav Mehta, Samuel J. Klempner, Jeeyun Lee. Tumor cell metaplastic programs and failure of T cell remodeling drive resistance and progression to frontline chemoimmunotherapy in advanced gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6846.
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SILVA (IFPA), Wagner Luiz Gonçalves da, and Gilberto de Miranda ROCHA (UFPA). "DINÂMICA ESPACIAL DE USO E OCUPAÇÃO DO SOLO URBANO NO MUNICÍPIO DE BREU BRANCO-PA." Revista Margens Interdisciplinar 14, no. 22 (February 19, 2021): 101. http://dx.doi.org/10.18542/rmi.v14i22.9648.
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Breu Branco é um município do estado do Pará, localizado na microrregião do lago de Tucuruí. Ao longo dos anos o município experimentou um crescimento populacional acelerado, consequência da migração de pessoas oriundas de outras regiões em busca de trabalho e moradia próximos às obras de barragem. O crescimento espacial tem forte relação com a Hidroelétrica. Além do fator populacional, outros três fatores foram importantes para o crescimento espacial de Breu Branco: o preço da terra, a topografia da área de expansão e a falta de políticas de proteção ambiental no município. Nesse trabalho utilizamos ferramentas cartográficas e sensoriamento remoto para a construção de mapas em três períodos 1996, 2006 e 2016. Os resultados obtidos mostram novas dinâmicas espaciais, como a duplicação da área urbana, saturação do núcleo projetado da cidade em direção ao norte, conversão de áreas de floresta e preservação (APP) em ocupações, concentração imobiliária e especulação sobre novas áreas, do ponto de vista populacional um aumento de 58% da população em vinte anos.Palavras-chave: Hidroelétrica. Território, Dinâmicas de uso e ocupação do solo. Cartografia. Plano diretor.SPATIAL DYNAMICS OF USE AND OCCUPATION OF URBAN SOIL IN THE MUNICIPALITY OF BREU BRANCO-PAAbstract: Breu Branco is a municipality in the state of Pará, located in the microregion of Lake Tucuruí. Over the years, the municipality experienced an accelerated population growth, a consequence of the migration of people from other municipalities of Pará and the northeast region of Brazil in search of work and housing near the works. The spatial growth has a strong relationship with the implementation phases of the Tucuruí HPP. In addition to the population factor, three other factors were important for the Breu Branco spatial growth: the price of land, the topography of the expansion area and the lack of environmental protection policies the municipality. In this work, we used cartographic tools and remote sensing for the construction of maps in three periods 1996, 2006 and 2016. The results obtained show new spatial dynamics, such as the duplication of the urban area, saturation of the projected nucleus of the city towards the north, conversion of forest and preservation areas (APP) into occupations, real estate concentration and speculation about new areas, from the point of view. population view an increase of 58% of the population in twenty years. Keywords: Hydroelectric.Territory. Dynamics of use and Soil occupation. Cartography. Master Plan.
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Lee, Meng-Hua, Kevin Louault, Krinio Giannikou, Xiangming Ding, Alice Yanovsky, Jin-Seok Park, Yves A. DeClerck, and Shahab Asgharzadeh. "Abstract 3543: Mesenchymal stromal cells and tumor-associated macrophages modulate adrenergic to mesenchymal state switching in neuroblastoma." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3543. http://dx.doi.org/10.1158/1538-7445.am2023-3543.
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Abstract Neuroblastoma (NB), a common solid tumor of children, can adopt a lineage-committed adrenergic (ADRN) or an immature mesenchymal (MES) tumor cell type, which differs in phenotype, epigenetic landscape, transcription factors, and core regulatory circuitries. These cell types can spontaneously interconvert, but the mechanism remains largely unknown. Here, we hypothesize that the tumor-associated macrophages (TAM) and cancer-associated fibroblast (CAF) within the tumor microenvironment contribute to pro-tumorigenic factors production and drive switching from ADRN to MES state in neuroblastoma. We first demonstrate the ADRN and MES lineage identity of NB cell lines by Western blot and compared the control and NB cell lines co-cultured with mesenchymal stromal cells (MSC), the precursor cell of CAF, and monocyte in transwell. Initial experiments demonstrated the morphology of NB cell line CHLA255 and CHLA136 showing increased spreading area and spindle shape in TAM-CAF co-cultures compared to control cells. As compared to control cells, monocytes and MSC-CAF co-culture induced the MES lineage markers SOX9 and Notch1 of NB cell lines that had low basal SOX9 expression, with a reduction in protein levels of ADRN lineage markers PHOX2B, and GATA3. Next, single-cell RNA-sequencing was utilized to analyze the expression of TAM and CAF, and MES- and ADRN-signature genes of NB cells in NB-TAM-CAF co-cultures. Single-cell analyses of TAM-CAF co-cultured CHLA255 and CHLA136 demonstrated enrichment of MES signature over time providing clear evidence of mesenchymal differentiation of NB cells within a TME-rich environment. Pathway enrichment analyses reveal enrichment of pathways associated with extracellular matrix (ECM) deposition and epithelial to mesenchymal of TAM-CAF co-cultured NB cell lines. Our results suggested that the presence of CAF and TAM in the tumor microenvironment drives neuroblastoma ADRN: MES switch akin to that observed in epithelial: mesenchymal switch in adult tumors. ADRN-MES state switching has been shown relevant for tumor relapse and therapy resistance. Our studies point to a therapeutic vulnerability by targeting cells and pathways activated in the NB-TAM-CAF axis. Citation Format: Meng-Hua Lee, Kevin Louault, Krinio Giannikou, Xiangming Ding, Alice Yanovsky, Jin-Seok Park, Yves A. DeClerck, Shahab Asgharzadeh. Mesenchymal stromal cells and tumor-associated macrophages modulate adrenergic to mesenchymal state switching in neuroblastoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3543.
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Groshong, Lisa, Sonja A. Wilhelm Stanis, Andrew T. Kaczynski, J. Aaron Hipp, and Gina M. Besenyi. "Exploring Attitudes, Perceived Norms, and Personal Agency: Insights Into Theory-Based Messages to Encourage Park-Based Physical Activity in Low-Income Urban Neighborhoods." Journal of Physical Activity and Health 14, no. 2 (February 2017): 108–16. http://dx.doi.org/10.1123/jpah.2016-0069.
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Background:Public parks hold promise for promoting population-level PA, but studies show a significant portion of park use is sedentary. Past research has documented the effectiveness of message-based strategies for influencing diverse behaviors in park settings and for increasing PA in nonpark contexts. Therefore, to inform message-based interventions (eg, point-ofdecision prompts) to increase park-based PA, the purpose of this study was to elicit insights about key attitudes, perceived norms, and personal agency that affect park use and park-based PA in low-income urban neighborhoods.Methods:This study used 6 focus groups with youth and adults (n = 41) from low-income urban areas in Kansas City, MO, to examine perceptions of key attitudinal outcomes and motivations, perceived norms, key referents, and personal agency facilitators and constraints that affect park use and park-based PA.Results:Participant attitudes reflected the importance of parks for mental and physical health, with social interaction and solitude cited as key motivations. Of 10 themes regarding perceived norms, influential others reflected participants’ ethnic makeup but little consensus emerged among groups. Social and safety themes were cited as both facilitators and constraints, along with park offerings and setting.Conclusions:Information about attitudes, perceived norms, and personal agency can increase understanding of theoretically derived factors that influence park-based PA and help park and health professionals create communication strategies to promote PA.
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Kelley, Kathleen, Jeffrey Hyde, James Travis, and Robert Crassweller. "Assessing Consumer Preferences of Scab-resistant Apples: A Sensory Evaluation." HortTechnology 20, no. 5 (October 2010): 885–91. http://dx.doi.org/10.21273/horttech.20.5.885.
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One hundred forty-nine consumers participated in a sensory evaluation, conducted on 14 Nov. 2008, at The Pennsylvania State University, University Park, PA, to determine consumer acceptance and perceptions of scab-resistant apples (Malus ×domestica). Consumers were exclusively screened for liking and eating apples. The study provides tree fruit growers and marketers in the mid-Atlantic United States with information on consumer preferences for apples that might substitute for common cultivars that require frequent apple scab pesticide applications. Resistant cultivars are also attractive in organic production systems. During the 10-minute sensory evaluation, panelists rated five scab-resistant apples [‘Crimson Crisp’, ‘GoldRush’, NY 75907–49 (NY 49), ‘Crimson Topaz’, and ‘Sundance’] and a commercially available non-resistant cultivar, Jonagold, on appearance, aroma, texture, flavor, and overall liking using a nine-point hedonic scale (9 = “like extremely” and 1 = “dislike extremely”). Three of the four apples tested with a red peel (‘Crimson Topaz’, NY 49, and ‘Crimson Crisp’) were rated significantly higher than the other apples on the basis of appearance, receiving mean ratings that were between “like moderately” and “like very much,” a rating of 7 and 8, respectively. In regards to texture, ‘Crimson Topaz’ and ‘Crimson Crisp’ were significantly higher than ‘Jonagold’ and NY 49, with mean ratings between “like slightly” and “like moderately.” For overall liking scores, ‘Crimson Crisp’, which was rated between “like slightly” and “like moderately,” was not significantly different from ‘Crimson Topaz’ and ‘GoldRush’; however, ‘Crimson Crisp’ was rated higher than ‘Jonagold’, NY 49, and ‘Sundance’. Panelists also responded to questions regarding their food-purchasing attitudes and behaviors. Sixty-two percent of panelists purchased fresh apples for themselves and/or other household members at least “two or three times a month” during an average year. Only 2.7% responded that they purchased fresh apples “more than once a week.” This study of consumer preferences provides an initial assessment of the feasibility of marketing new apple cultivars and organic apples within the mid-Atlantic U.S. region. Those that performed well in the sensory evaluation should be candidates for additional market research.
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Santos, Gedinara Paiva dos, Amanda Frederico Mortati, Luis Gustavo De Castro Canani, and Leidiane Leão Oliveira. "Efeitos da integridade ambiental da zona ciliar e sua influência na qualidade da água de igarapés urbanos em Santarém-PA, Amazônia, Brasil." Revista Brasileira de Geografia Física 14, no. 7 (January 3, 2022): 4035. http://dx.doi.org/10.26848/rbgf.v14.7.p4035-4055.
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Os igarapés urbanos são afetados pela supressão da floresta ripária o que ocasiona degradação ambiental. Devido às atividades antrópicas, esses ambientes são alterados e descaracterizados, sofrendo profundas mudanças em suas estruturas aquática e terrestre. Essas alterações se refletem na qualidade das águas, e usualmente são estimadas através da análise quantitativa de parâmetros hidrológicos e físico-químicos. O Índice de Integridade do Habitat (IIH) é um método qualitativo de avaliação das condições ambientais dos igarapés. Este estudo busca avaliar se a variação da integridade do habitat reflete a variação hidrológica e físico-química decorrente das alterações antrópicas nos ambientes aquáticos. Foram medidas as variáveis ambientais da zona ripária (Índice de Integridade do Habitat - IIH e cobertura vegetal média); do canal (vazão, largura e profundidade médias) e da água (pH, condutividade, oxigênio dissolvido e turbidez médias, temperatura média) em de seis igarapés urbanos de Santarém- PA. Dos seis igarapés analisados, cinco encontram-se em estado degradado e com a área de proteção permanente em desacordo com o Código Florestal Brasileiro. Foi avaliada a correlação do IIH com as variáveis ambientais e análise de variância para verificar se houve diferença significativa entre os valores das variáveis ambientais nos pontos amostrados. Verificou-se que o Índice de Integridade do Habitat - IIH apresentou uma correlação significativa (p<0,05) com as variáveis oxigênio dissolvido e condutividade, sendo capaz de captar a influência destas variáveis na qualidade da água. Em termos de variação espacial dos parâmetros físico-químicos, o Ponto 6 se destacou com o maior número de diferenças significativas em relação aos demais pontos amostrados e foi o único classificado pelo IIH como íntegro, demonstrando que o IIH foi capaz de detectar a variação da qualidade da água e que pode ser uma ferramenta para um rápido e efetivo diagnóstico das condições ambientais de corpos d’água. Diante dos resultados, medidas de recuperação devem ser tomadas para minimizar e reverter as fontes de impacto que promovem a degradação dos igarapés urbanos na cidade de Santarém- PA.Palavras-chave: Gestão de microbacias urbanas, qualidade da água, mata ciliar. Effects of the environmental integrity of the riparian zone and its influence on the water quality of urban streams in Santarém-Pa, Amazonia, Brazil A B S T R A C TUrban streams are affected by the suppression of riparian forest, which causes environmental degradation. Due to human activities, these environments are altered and uncharacterized, undergoing profound changes in their aquatic and terrestrial structures. These changes are reflected in the water quality and are usually estimated through the quantitative analysis of hydrological and physical-chemical parameters. The Habitat Integrity Index (IIH) is a qualitative method for assessing the environmental conditions of streams. This study aims to assess whether the variation in habitat integrity reflects the hydrological and physical-chemical variation resulting from anthropic changes in aquatic environments. The environmental variables from the riparian zone (Habitat Integrity Index - IIH and average vegetation cover), from the channel (mean flow, width, and depth) and from the water (pH, average conductivity, dissolved oxygen and turbidity, average temperature) were measured; in six urban streams in Santarém-PA. Among the six streams analyzed, five are in a degraded state and have a permanent protection area that does not comply with the Brazilian Forest Code. The correlation of the IIH with the environmental variables and an analysis of variance was performed in order to verify if there was a significant difference between the environmental variables’ values at the sampled points. It was found that the Habitat Integrity Index - IIH showed a significant correlation (p <0.05) with the variables dissolved oxygen and conductivity, being able to capture the influence of these variables on water quality. In terms of spatial variation of the physical-chemical parameters, the Point 6 stood out with the largest number of significant differences in relation to the other sampled points and was the only one classified by the IIH as intact, which demonstrates that the IIH could detect the variation of the water quality and that it can be a tool for a quick and effective diagnosis of the environmental conditions of water bodies. In view of the results, recovery measures must be taken to minimize and reverse the sources of impact that promote the degradation of urban streams in the city of Santarém-PA.Keywords Management of urban micro basins, water quality, riparian forest.
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Domanskyi, Sergii, Todd B. Sheridan, Brian J. Sanderson, SungHee Park, Jessica Kaster, Haiyin Li, Olga Anczukow, Meenhard Herlyn, Jeffrey H. Chuang, and Jill C. Rubinstein. "Abstract A010: Longitudinal histology and spatial transcriptomics profiling in targeted treatment of melanoma patient-derived models interrogates persister and resistant cell populations." Cancer Research 84, no. 3_Supplement_2 (February 1, 2024): A010. http://dx.doi.org/10.1158/1538-7445.canevol23-a010.
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Abstract Over half of BRAF-mutant melanoma patients with initial response to targeted therapy will recur with resistant disease. It is thought that recurrence arises from the ability of resistant clonal populations to enter and exit a slow-cycling persister state, evading treatment in quiescence before returning to a proliferative state. However, clonal transcriptional profiles and their spatial relationships in the tumor environment are not well characterized. Through longitudinal profiling of tumors from pre-treatment through the growth of resistant tumors, we track clonal lineages and transcriptional state changes to identify recurrent evolutionary patterns. BRAF mutant patient-derived melanoma xenografts were treated with BRAF/MEK inhibitors through maximum tumor size reduction and re-growth. Spatial transcriptomics (ST) and H&E histological staining were performed at five timepoints across 94 and 133 days of PDX models WM4237 and WM4007 treatment, tracking clonal populations with intact tissue structure. Deep learning feature extraction on high-resolution H&E-stained images allowed the detection of histological features that co-localize with expression levels. A novel computational workflow performed integration of samples across time points, pathway enrichment analysis, and pseudotemporal ordering, allowing spatial recreation of copy number variation based clonal phylogenies and cell fate trajectory inference during the treatment course. We characterize the clonal populations by the burden of accumulated copy number variations and establish clonal phylogeny. With the added temporal resolution, ST profiling during melanoma treatment enables observation of a global shift where all lineages begin the transition into the persister transcriptional state. The drug-sensitive cells are eliminated due to treatment, and distinct transcriptional states arise due to metabolic plasticity regardless of the lineage of origin. The clones of the transient persister state constitute the minimal residual disease, where melanoma cells have an increase in invasive capacity and a slowing of the cell cycle. The ability to survive through the persister state and re-emerge into a proliferating clone where the cell cycle is upregulated varies by lineage. We observe that the transcriptional changes during emergence from dormancy show decreased invasiveness and continued reliance on oxidative respiration versus glycolysis. We compare the re-emerged resistant cell populations and pre-treatment samples to pinpoint the changes in the transcriptional state of the MAPK signaling pathway and find that sets of upregulated genes differ by the model, WM4237 and WM4007. We connect deep learning imaging features extracted from longitudinal histology profiling to ST profiles to associate histology data with the cell cycle activation, invasiveness, hypoxia state, and metabolic mode across the timepoints. We observe that the imaging features alone can be potentially used to track the evolution of the tumor cell population phenotypes during drug treatment. Citation Format: Sergii Domanskyi, Todd B. Sheridan, Brian J. Sanderson, SungHee Park, Jessica Kaster, Haiyin Li, Olga Anczukow, Meenhard Herlyn, Jeffrey H. Chuang, Jill C. Rubinstein. Longitudinal histology and spatial transcriptomics profiling in targeted treatment of melanoma patient-derived models interrogates persister and resistant cell populations [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Translating Cancer Evolution and Data Science: The Next Frontier; 2023 Dec 3-6; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(3 Suppl_2):Abstract nr A010.
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Toselli, Stefania, Laura Bragonzoni, Laura Dallolio, Grigoletto Alessia, Alice Masini, Sofia Marini, Giuseppe Barone, et al. "The Effects of Park Based Interventions on Health: The Italian Project “Moving Parks”." International Journal of Environmental Research and Public Health 19, no. 4 (February 14, 2022): 2130. http://dx.doi.org/10.3390/ijerph19042130.
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Obesity and physical inactivity are global health problems responsible for the risk increment of noncommunicable diseases. To overcome these problems, interventions aimed at increasing physical activity (PA) are necessary. Green space can have a positive influence on promoting PA, so, the aim of the present study was to assess the effectiveness of the project “The moving parks project”, which provides for the administration of PA to citizens within Bologna’s parks (Italy). An ad hoc questionnaire was administered before and after three months of outdoor PA. A total of 329 adult subjects participated in the survey. At follow-up, all psychosocial parameters showed an improvement, with a reduction in the state of tension, sadness and fatigue, and an improvement in the state of energy, serenity, and vitality. The impact of the interventions carried out in the “Moving Parks project” was positive and appears to be a good strategy for improving health outcomes.
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Klyukanov, Igor. "Embodiment, Relation, Community: A Continental Philosophy of Communication, Garnet Butchart (2019)." Empedocles: European Journal for the Philosophy of Communication 14, no. 1 (April 1, 2023): 91–96. http://dx.doi.org/10.1386/ejpc_00054_5.
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Review of: Embodiment, Relation, Community: A Continental Philosophy of Communication, Garnet Butchart (2019) University Park, PA: Pennsylvania State University Press, 199 pp., ISBN 978-0-27108-325-4, h/bk, $80.95
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Hancock, Rae. "Drawing on Religion: Reading and the Moral Imagination in Comics and Graphic Novels, Ken Koltun-Fromm (2020)." Studies in Comics 12, no. 1 (November 1, 2021): 163–67. http://dx.doi.org/10.1386/stic_00060_5.
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Review of: Drawing on Religion: Reading and the Moral Imagination in Comics and Graphic Novels, Ken Koltun-Fromm (2020) University Park, PA: The Pennsylvania State University Press, ISBN 978-0-271-08775-7, p/bk, £27.95
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Frandsen, Steen Bo. "Beyond the Multinational States: the Revival of Nations and Nationalism." Contemporary European History 10, no. 2 (July 2001): 295–305. http://dx.doi.org/10.1017/s0960777301002065.
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Rogers Brubaker, Nationalism Reframed: Nationhood and the National Question in the New Europe (Cambridge: Cambridge University Press, 1996), 202 pp., ISBN 0-521-57649-0. Michael Forman, Nationalism and the International Labor Movement. The Idea of the Nation in Socialist and Anarchist Theory (University Park, PA: Pennsylvania State University Press, 1998), 212 pp., cloth $35.00, paper $17.95, ISBN 0-271-01727-9. Ilya Prizel, National Identity and Foreign Policy. Nationalism and leadership in Poland, Russia and Ukraine (Cambridge: Cambridge University Press, 1998), 443 pp., hardback £50.00, paperback £16.95 ($54.95 / $24.95), ISBN 0-521-57697-0. Andrew Baruch Wachtel, Making a Nation, Breaking a Nation. Literature and Cultural Politics in Yugoslavia (Stanford: Stanford University Press, 1998), 302 pp., cloth $55.00, paper $18.95, ISBN 0-804-73181-0. Yitzhak M. Brudny, Reinventing Russia. Russian Nationalism and the Soviet State 1953–1991, (Cambridge, MA: Harvard University Press, 1998), 352 pp., ISBN 0-674-75408-5. Catherine Wanner, Burden of Dreams. History and Identity in Post-Soviet Ukraine (University Park, PA: Pennsylvania State University Press, 1998), 255 pp., cloth $50.00, paper $18.95, ISBN 0-271-01793-7.
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Simonson, Brandon. "Review of Historical Implications of Jewish Surnames in the Old Kingdom of Romania by Alexander Avram." Names 70, no. 2 (June 3, 2022): 57–59. http://dx.doi.org/10.5195/names.2022.2393.
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Review of Historical Implications of Jewish Surnames in the Old Kingdom of Romania. By Alexander Avram. Studies in Jewish Onomastics: The Project for the Study of Jewish Names. University Park, PA: Penn State University Press, 2021. Pp. 296 + xi. $115.00 (hard back), ISBN 9780271091426.
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McArthur, Heather, Jorge Henrique Santos Leal, Christina DiLauro Abaya, Sangeetha Reddy, Meredith Carter, Reva Basho, Michelle Phillips, et al. "Abstract OT3-25-01: Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial." Cancer Research 83, no. 5_Supplement (March 1, 2023): OT3–25–01—OT3–25–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot3-25-01.
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Abstract Background: Immune checkpoint inhibition (ICI) is synergistic with HER2-directed therapy in pre-clinical models. Clinically, pembrolizumab (K)-mediated ICI plus HER2-directed therapy with trastuzumab (H) was safe and demonstrated modest activity in H-resistant HER2-positive (HER2+) metastatic breast cancer. Because ICI may confer more robust activity when administered earlier in the course of disease, H and K administered in the curative-intent, treatment-naive setting may allow for de-escalation of cytotoxic chemotherapy; confer life-long, tumor-specific immunity; and ultimately, improve cure rates. Moreover, the synergy of H and K with paclitaxel (T) may overcome the need for dual HER2-blockade with H plus pertuzumab (P). In this randomized, multicenter, phase II, open-label, multi-center trial the efficacy and safety of neoadjuvant THP vs THP-K vs TH-K are explored. Methods: 174 patients (pts) ≥18y with previously untreated, stage II-III, HER2+ breast cancer will be randomized and stratified by clinical nodal status (positive vs. negative) and hormone receptor status (positive vs. negative). In arm A, pts receive T at 80mg/m2 weekly for 12 weeks, H at 8mg/Kg (loading dose) and then 6mg/Kg every 3 weeks x 3 doses, P at 840 mg (loading dose) and then 420mg/Kg every 3 weeks x 3 doses (THP). In arm B, pts receive THP plus K at 200mg every 3 weeks x 4 doses (THP-K). In arm C, pts receive TH-K; however, in a preplanned interim analysis, arm C did not meet the pre-defined efficacy threshold and this arm was subsequently closed. Enrollment to arms A and B continue. Definitive surgery is 3-6 weeks after the last dose. After surgery, pts are treated per the treating physician’s discretion including radiotherapy per local clinical standard. Pts whose tumors are hormone-receptor positive will receive hormone therapy per local standard-of-care. The primary end point is pathologic complete response (pCR) rate in the breast and axilla (ypT0/Tis ypN0). Secondary end points include pCR rate by ypT0ypN0 and ypT0/Tis, residual cancer burden index, event free survival, breast conserving surgery rate, safety and overall survival. Exploratory correlative studies will characterize potential immune biomarkers predictive of efficacy and/or toxicity. Funding sources: BCRF, Merck NCT03747120 Citation Format: Heather McArthur, Jorge Henrique Santos Leal, Christina DiLauro Abaya, Sangeetha Reddy, Meredith Carter, Reva Basho, Michelle Phillips, David Chan, Hugo Hool, Dorothy Park, Mary El-Masry, Philomena McAndrew, Swati Sikaria, Laura M. Spring, Aditya Bardia, Mourad Tighiouart, Farnaz Dadmanesh, Armando Giuliano, Stephen Shiao, David B. Page. Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr OT3-25-01.
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Jakob, Stefan. "Neo-Assyrian Specialists: Crafts, Offices, and Other Professional Designations. By Heather D. Baker." Journal of the American Oriental Society 140, no. 4 (September 19, 2021): 1024. http://dx.doi.org/10.7817/jaos.140.4.2020.brev013.
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Neo-Assyrian Specialists: Crafts, Offices, and Other Professional Designations. By Heather D. Baker. The Prosopography of the Neo-Assyrian Empire, vol. 4, pt. 1, Professions Index . Helsinki: The Neo- ASssrian Text Corpus Project, 2017. Pp. xvii + 397. $94 (paper). [Distributed by Penn State Univ . Press, University Park, PA]
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Goldfarb, Shari B., Victoria Blinder, Devika Gajria, Cassandra Chang, Analisa Dacunto, Jinae Park, Monica Fornier, and Mario Lacouture. "Abstract P5-08-10: Safety and Tolerability of Paxman Scalp Cooling at Lower Temperatures to Improve Efficacy with Anthracycline Chemotherapy." Cancer Research 83, no. 5_Supplement (March 1, 2023): P5–08–10—P5–08–10. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-08-10.
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Abstract Background: Chemotherapy induced alopecia is one of the most distressing side effects of cancer therapy since it is a constant reminder of the underlying malignancy. Anthracycline chemotherapy induces total alopecia. Although scalp cooling devices have been used to prevent this alopecia, there is still a need to improve efficacy with anthracycline therapy. This study was performed to evaluate if the Paxman Scalp Cooling System is safe, tolerable, and more efficacious at lower temperatures. Objectives: The primary end point is to assess the safety and tolerability of the Paxman Scalp Cooling System at lower temperatures (-7.5 Celsius and -10 Celsius), defined as the ability of patients to undergo scalp cooling without any DLTs during the treatment period. The secondary end point is successful hair preservation assessed using the Common Terminology Criteria for Adverse Events version 4.0 scale (grade 0 [no hair loss] or grade 1 [< 50% hair loss not requiring a wig] were considered to have hair preservation) after anthracycline chemotherapy. Methods: 34 women with stage I-III breast cancer who were receiving anthracycline-based neoadjuvant or adjuvant therapy were enrolled on study. The first 7 patients received scalp cooling at -7.5 Celsius and the subsequent 27 patients received scalp cooling at -10 Celsius. Patients completed safety and tolerability assessments at each visit. In addition, participants had standardized scalp photography to assess the superior, vertex and frontal scalp views, trichoscopic assessments, alopecia grading and completed PROs (CADS, Tolerability, Change in scalp coverage). Results: Thirty-four women (56% White, 18% Black, 8% Asian, 18% other) with a mean age of 44 (range 20-68) were enrolled on this IRB-approved pilot study. Seventy-four percent received ddAC-T, 18% received ddAC-THP and 8% received ddAC/Pembro-T/Carbo/Pembro. Twenty-six patients were evaluable for the DLT end point. Three patients are still on study and five patients left the study before completion (2 due to lack of efficacy, 1 shaved her head, 1 was removed from study due to hospitalization for sepsis and 1 patient changed her mind and never started scalp cooling). There were no DLTs in any patient throughout the study. Both the -7.5 and -10 Celsius temperatures were found to be tolerable with no difference in tolerability. The most common reported AEs were headaches 48%, discomfort 13%, scalp pain 9.7%, dizziness 9.6%, scalp coldness 6%, feeling cold 3% and lightheadedness 3%. Twenty-nine percent of patients reported that scalp cooling triggered a headache and the average level of pain was mild. Only 16% of patients reported pain killer use due to scalp cooling, which effectively resolved headaches or discomfort. Sixty-one percent of patients reported hair preservation at the primary end point. Hair regrowth was reported in patients after they experienced grade 2 alopecia and while still on study. More detailed data on hair preservation will be forthcoming once all of the photos and trichoscopic measures are assessed. Conclusions: Paxman Scalp Cooling System is safe, tolerable and even more efficacious at lower temperatures. The -10 Celsius is more efficacious and as tolerable as -7.5 in patients being treated with anthracycline therapy. When using the Paxman Scalp Cooling System in patients being treated with anthracycline therapy, you should consider performing scalp cooling at lower temperatures Table 1: Demographics Citation Format: Shari B. Goldfarb, Victoria Blinder, Devika Gajria, Cassandra Chang, Analisa Dacunto, Jinae Park, Monica Fornier, Mario Lacouture. Safety and Tolerability of Paxman Scalp Cooling at Lower Temperatures to Improve Efficacy with Anthracycline Chemotherapy [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-08-10.
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Blanco, Sofía T., Inmaculada Velasco, Evelyne Rauzy, and Santos Otín. "Dew points of ternary methane + water + methanol. Measurement and correlation." Canadian Journal of Chemistry 78, no. 12 (December 1, 2000): 1587–93. http://dx.doi.org/10.1139/v00-151.
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A water and methanol dew point generation device has been built up and tested. Experimental measurements of dew point for ternary methane + water + methanol were carried out between 1.01 × 105 Pa to 97.84 × 105 Pa and the temperature range from 248.71 to 282.93 K. A EOS-CR method (equation of state chemical reticular) reproduces very accurately the experimental curves independently of the pressure and temperature ranges.Key words: dew point, experimental method, equation of state, excess function.
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Finney, Mark A., and Robert E. Martin. "Fire history in a Sequoiasempervirens forest at Salt Point State Park, California." Canadian Journal of Forest Research 19, no. 11 (November 1, 1989): 1451–57. http://dx.doi.org/10.1139/x89-221.
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Fire occurrence data between the 12th and 20th centuries were obtained from analysis of fire scars on coast redwood (Sequoiasempervirens (D. Don.) Endl.) and bishop pine (Pinusmuricata D. Don.). Mean fire intervals were calculated for settlement and presettlement periods from fire scar samples individually (point data) and from composites of samples aggregated within three approximately 200-ha study areas. Mean fire intervals from point data (20.5 to 29.0 years) were more than three times greater than mean intervals from composite data (6.1 to 9.3 years). Mean fire intervals derived from point data compared well with values previously reported, although substantial bias ascribed to point data suggests that these values for mean fire intervals in redwood forest communities are too large. A period of significantly longer fire intervals during the 17th century was suggested by analysis of fire intervals by century and using a moving average.
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McArthur, Heather, Jorge Henrique Santos Leal, Isaac Chan, Nisha Unni, Stephen Shiao, Joshua Gruber, Samira Syed, et al. "Abstract PO5-19-08: Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO5–19–08—PO5–19–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-19-08.
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Abstract Background: Immune checkpoint inhibition (ICI) is synergistic with HER2-directed therapy in pre-clinical models. Clinically, pembrolizumab (K)-mediated ICI plus HER2-directed therapy with trastuzumab (H) was safe and demonstrated modest activity in H-resistant HER2-positive (HER2+) metastatic breast cancer. Because ICI may confer more robust activity when administered earlier in the course of disease, H and K administered in the curative-intent, treatment-naive setting may allow for de-escalation of cytotoxics; confer life-long, tumor-specific immunity; and ultimately, improve cure rates. Moreover, the synergy of H and K with paclitaxel (T) may overcome the need for dual HER2-blockade with H plus pertuzumab (P). In this randomized, multicenter, phase II, open-label trial the efficacy and safety of neoadjuvant THP vs THP-K vs TH-K are explored. Methods: Patients (pts) ≥18y with previously untreated, stage II-III, HER2+ breast cancer are being randomized and stratified by clinical nodal status (positive vs. negative) and hormone receptor status (positive vs. negative). In arm A, pts receive T at 80mg/m2 weekly for 12 weeks, H at 8mg/Kg (loading dose) and then 6mg/Kg every 3 weeks x 3 doses, P at 840 mg (loading dose) and then 420mg/Kg every 3 weeks x 3 doses (THP). In arm B, pts receive THP plus K at 200mg every 3 weeks x 4 doses (THP-K). In arm C, pts receive TH-K. After enrollment of 22 pts to arm C, a prespecified interim efficacy analysis was conducted, and enrollment to this arm was subsequently terminated. Enrollment to the other arms continues with 32/58 pts enrolled to arm A and 33/58 pts enrolled to arm B as of 2/14/2023. Definitive surgery is 3-6 weeks after the last dose. After surgery, pts are treated per the treating physician’s discretion per local clinical standard. The primary end point is pathologic complete response (pCR) rate in the breast and axilla (ypT0/Tis ypN0). Secondary end points include pCR rate by ypT0ypN0 and ypT0/Tis, residual cancer burden index, event free survival, breast conserving surgery rate, safety and overall survival. Exploratory correlative studies will characterize potential immune biomarkers predictive of efficacy and/or toxicity. Funding sources: BCRF, Merck NCT03747120 Citation Format: Heather McArthur, Jorge Henrique Santos Leal, Isaac Chan, Nisha Unni, Stephen Shiao, Joshua Gruber, Samira Syed, Namrata Peswani, Navid Sadeghi, Glenda Delgado, Dawn Klemow, Reva Basho, Meredith Carter, Mai Badran, Nasir Qureshi, Jessica Curtin, Joshua Weese, Stephanie Rice, Michelle Phillips, David Chan, Hugo Hool, Dorothy Park, Mary El-Masry, Philomena McAndrew, Swati Sikaria, Laura Spring, Aditya Bardia, Mourad Tighiouart, Farnaz Dadmanesh, Armando Giuliano, Katherine Sanchez, David Page. Neoadjuvant HER2-targeted Therapy +/- Immunotherapy with Pembrolizumab (neoHIP): An Open Label Randomized Phase II Trial [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-19-08.
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Furlong, Matthew. "Nathan Widder (2008) Reflections on Time and Politics, University Park, PA: Pennsylvania State University Press." Deleuze Studies 6, no. 3 (August 2012): 504–12. http://dx.doi.org/10.3366/dls.2012.0077.
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Gross, Alan G. "Book Review: Landau, Iddo. (2006). Is Philosophy Androcentric? University Park, PA: The Pennsylvania State Press." Philosophy of the Social Sciences 38, no. 3 (September 2008): 400–404. http://dx.doi.org/10.1177/0048393108319474.
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Goldman, Alan H. "Real BeautyEddy M. Zemach University Park, PA: Pennsylvania State University Press, 1997, xi + 222 pp." Dialogue 38, no. 3 (1999): 667–71. http://dx.doi.org/10.1017/s001221730004717x.
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Lee, Charles E. "CASE HISTORY OF SHORE PROTECTION AT PRESQUE ISLE PENINSULA, PA." Coastal Engineering Proceedings 1, no. 3 (January 1, 2000): 24. http://dx.doi.org/10.9753/icce.v3.24.
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The beach protection aspects rather than the importance to navigation of Presque Isle Peninsula is stressed in this paper, The history of the locality is so extensive that only that which bears on beach protection and the portion deemed pertinent to provide background to the early importance of the site will be related. The three main reasons for protecting Presque Isle Peninsula are as follows: for protection of the natural harbor at Erie, Pennsylvania; for the preservation of the beaches which provide Pennsylvania's only public lakeshore recreational area on Lake Erie; and to prevent destruction of the only land access to the facilities on the peninsula. It is reported that in 1947 over 1,500,000 people visited the 3,200 acre Presque Isle State Park. There are also located on the peninsula installations of the Erie Water Works, the United States Coast Guard and the Pennsylvania State Department of Fisheries.
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Pioli, R. N., L. Mozzoni, and E. N. Morandi. "First Report of Pathogenic Association Between Fusarium graminearum and Soybean." Plant Disease 88, no. 2 (February 2004): 220. http://dx.doi.org/10.1094/pdis.2004.88.2.220a.
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Fusarium graminearum, a pathogen of wheat and corn, was reported recently as a saprophytic fungus colonizing soybean (Glycine max L. Merr.) fruits and seeds at R7 in Argentina (2). To evaluate the capacity of F. graminearum obtained from stem and seeds of symptomatic soybean plants that cause disease on soybean seedlings, isolates were obtained during the 2001 to 2002 growing season from: (i) the basal one-third of stems from field-grown soybean plants, collected at R5, with light brown external and internal discoloration and leaves with interveinal chlorosis; and (ii) soybean seeds with pink tegument. The pathogen was isolated on potato glucose agar acidified with 0.2% lactic acid (PGAA). Isolates were identified as F. graminearum on the basis of growth rate and pigmentation of colonies on PGAA, lack of microconidia (1), and morphology and size of typical macroconidia in sporodochia developed on Spezieller Nährstoffarmer Agar (3). Isolates of F. graminearum, CE135 and CE136 (from wheat) and CE137 (from corn) deposited in the Centro de Referencia en Micología (CEREMIC), Fac. Farmacia y Bioquímica, UNR, Argentina, were used as references in identifying the soybean isolates. Plants (14-day-old) were inoculated separately with stem and seed isolates in the greenhouse at 26 ± 2 and 20 ± 2°C day/night temperature by inserting a piece of mycelium into a wound made with a scalpel in the hypocotyl. A completely randomized block design (RCB) was utilized with four replicate pots with four plants per pot. Plants wounded but without mycelium served as controls. This test was conducted twice (experiments 1 and 2). Another test was completed by burying a thin layer of wheat caryopsis colonized by fungal mycelium of the stem isolate CE170 in the soil of pots. Plants in pots with soil without inoculum served as controls (4). The experiment was conducted twice (experiments 3 and 4) in an RCB with five replications, four plants per replication. The progress of symptoms in experiments 1 and 2 were stem with light brown discoloration around the inoculation point that extended progressively along the stem, interveinal chlorosis or loss of turgence of unifoliate leaves, and interveinal chlorosis of trifoliate leaves followed by plant wilting and death. Twenty-one days after inoculation, average percentages of dead plants (%DP) was 42 and 21% for stem and seed isolates, respectively. For experiments 3 and 4, %DP was 56%, 45 days after emergence. These plants had roots with light brown, necrotic areas. Control plants remained healthy. The pathogen was reisolated from the stem (100%) and root (57%) tissues of symptomatic plants but not from similar tissues of control plants. To our knowledge, this is the first report of a pathogenic relationship between F. graminearum and soybean. References: (1) P. E. Nelson et al. Fusarium species: An Illustrated Manual for Identification. The Pennsylvania State University Press, University Park, PA, 1983. (2) R.N. Pioli et al. Fitopatología 35(2):111, 2000. (3) B. A. Summerell et al. Plant Dis. 87:117, 2003. (4) C. E. Windels. Fusarium. Pages 115–128 in: Methods for Research on Soilborne Phytopathogenic Fungi. L. L. Singleton, J. D. Mihail, and C. M. Rush, eds. The American Phytopathological Society, St. Paul, MN, 1992.
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Woolrych, Austin. "Robert Thomas Fallon. Milton in Government. University Park, Pa.: Penn State Press. Pp. xvi, 288. $42.50." Albion 26, no. 1 (1994): 136–38. http://dx.doi.org/10.2307/4052117.
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Zueva, Olga. "The system of specially protected natural areas of Kuzbass." BIO Web of Conferences 31 (2021): 00034. http://dx.doi.org/10.1051/bioconf/20213100034.
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On the territory of Kuzbass there are 29 specially protected natural areas with a total area of 1.3 thousand hectares. The existing system of protected areas of Kuzbass is a protected area of federal significance (the State Nature Reserve Kuznetskiy Alatau, the National Natural Park Shorskiy, the State Natural Monument Lipovy Ostrov), 22 protected areas of regional and 4 protected areas of municipal importance. The purpose of this study is to analyze the location of specially protected natural areas in terms of the floristic zoning of Kuzbass and the primary analysis of the PA system in Kuzbass.
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Fitzgerald, Richard, and Michael Rondeau. "A Fluted Projectile Point from Crystal Cove State Park, Orange County, Alta California." California Archaeology 4, no. 2 (December 2012): 247–56. http://dx.doi.org/10.1179/cal.2012.4.2.247.
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Kim, ji-Yeon, Kyunghee Park, woong-Yang Park, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Se Kyung Lee, and Yeon Hee Park. "Abstract P6-01-37: Tumor microenvironment subtype influence the response of neoadjuvant chemotherapy in breast cancer." Cancer Research 83, no. 5_Supplement (March 1, 2023): P6–01–37—P6–01–37. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-01-37.
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Abstract Introduction Recent transcriptome analysis developed a holistic tumor microenvironment (TME) classification platform based on immune and fibrotic markers. This TME classification had four categories, immune enriched, fibrotic (IE/F); immune enriched, non-fibrotic (IE); Fibrotic (F); and Immune Desert (D). And these four TME subtypes are a predictive biomarker to immunotherapy in multiple cancer and four subtypes have been changed during treatment. Previously our study suggested baseline immune features and dynamic immune response on-treatment were predictive of treatment outcome in BC with neoadjuvant chemotherapy (NAC). In this study, we evaluated the impact of TME classification and dynamic change of TME classification on treatment outcome in BC with NAC. Methods Early and locally advanced BCs which would be planned to receive standard NAC (four cycles of anthracycline plus cyclophosphamide and four cycles of docetaxel or docetaxel plus trastuzumab for human epidermal growth factor receptor 2[HER2+] disease or six cycles of docetaxel, carboplatin, trastuzumab and pertuzumab for HER2+ disease) followed by curative surgery. We prospectively collected tumor tissue and matched blood three times for each patients: at BC diagnosis (T1), three weeks after the first cycle of NAC (T2), and curative surgery (T3). RNASeq was performed to classify TME subtype. In terms of clinical variables, clinical stage and IHC subtype at diagnosis, pathologic complete response (pCR), distant recurrence free survival (DRFS) and overall survival (OS) were used. Generalized logistic regression was used for predicting RCB class and pCR with clinical and genomic characteristics at T1. Kaplan-Meier analysis were performed to analysis DRFS and OS. Results In total, 210 patients who were treated with scheduled NAC were enrolled. Finally, RNASeq in 240 BC tissues (T1:119, T2:91 and T3:30) were conducted from 142 patients. In 119 BCs which was performed RNASeq at T1, hormone receptor(HR)+, HER2- BC was 32 (26.9%), 29 of HR+HER2+ BC (24.4%), 18 of HR-HER2+ BC (15.1%) and 44 of triple negative BC (TNBC) (37.0%). In TME classification, immune desert (D) was most frequently observed (45.3%), followed by IE (35.3%), F (10.1%) and IE/F (9.2%). The association between BC subtype and TME subtype suggested that HR+HER2- BC was frequently categorized into D (22 of 32, 68.8%) whereas TNBC was into IE (24 of 44, 54.5%) (p< 0.001). TME subtype has been dynamically changed during NAC. At T2, IE subtype was most frequently observed (27.5%) followed by D (25.3%), IE/F (24.2%) and F (23.1%). The inclination of TME change were different according to NAC response. In BC achieved pCR, IE/F subtype had increased (4 at T1 and 10 at T2) and decrease of D subtype (15 at T1 and 3 at T2). In BC with non-pCR, IE/F subtype had slightly increased at T2 (7 at T1 and 12 at T2) but there was no IE/F subtype at T3 point. Contrarily, D subtype had decreased at T2 but increased at T3 (39 at T1, 20 at T2 and 24 at T3). The impact of TME subtype was different according to pCR status. In BC with pCR, F subtype had poor prognosis in DRFS and OS compared to other subtype ([5year DRFS rate for F vs. others: 66.7% vs. 93.2%, p=0.028], [5year OS rate for F vs. others: 70.7% vs. 100%, p< 0.001]). In BC without pCR, there was no different DRFS and OS according to TME subtypes. Conclusion Our data suggested that TME subtype has been changed during NAC and the subtype switching was affected by the NAC response. Moreover, TME subtype may have prognostic role in DRFS and OS according to pCR status. Citation Format: ji-Yeon Kim, Kyunghee Park, woong-Yang Park, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Se Kyung Lee, Yeon Hee Park. Tumor microenvironment subtype influence the response of neoadjuvant chemotherapy in breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P6-01-37.
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Orozco-Quintero, Alejandra, Leslie King, and Rosaline Canessa. "Interplay and Cooperation in Environmental Conservation: Building Capacity and Responsive Institutions Within and Beyond the Pacific Rim National Park Reserve, Canada." SAGE Open 10, no. 2 (April 2020): 215824402093268. http://dx.doi.org/10.1177/2158244020932683.
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Although protected areas (PAs) have become pivotal components in the pursuit of environmental sustainability, they have had mixed success in achieving environmental goals, in part due to internal factors such as governance design and insufficient ability to operate within, and connect to, wider social, economic, and institutional frameworks. A growing body of scholarship reveals that there are fundamental mismatches between rhetoric and practice in state-driven “participatory” conservation, and that state–community cooperation is extremely challenging. This study draws on data from qualitative research on institutions and interactions in conservation planning and management to examine factors influencing collaboration between Parks Canada and Nuu-chah-nulth communities adjacent to the Pacific Rim National Park Reserve. We consider the evolution of policies, institutional arrangements, state-community interactions, and socio-cultural and legal frameworks within which state-led conservation takes place to assess progress in multilevel cooperation. We found that despite differences in degrees of authority and decision-making power, and a land tenure framework that favors the state, there is a shift from domination toward negotiation in the interplay between the federal government and grassroots actors. That shift is linked to the recognition of First Nations’ ancestral tenure and custodianship, and the particularities of grassroots and state leadership. The findings suggest significant progress in sustaining the PA as a multilevel effort, and that cooperation in conservation helps all parties to build capacity for environmental stewardship beyond the PA and to fashion conservation institutions that are responsive to changing social–ecological conditions.
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Kennedy, William J. "Sara Sturm-Maddox. Petrarch's Laurels. University Park, PA: Pennsylvania State University Press, 1992. viii + 310 pp. $39.50." Renaissance Quarterly 47, no. 3 (1994): 649–50. http://dx.doi.org/10.2307/2863027.
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Bauer, Nancy. "BOOK REVIEW: Margaret A. Simons.FEMINIST INTERPRETATIONS OF SIMONE DE BEAUVOIR.University Park, PA: Pennsylvania State University Press, 1995." Hypatia: A Journal of Feminist Philosophy 11, no. 3 (July 1996): 161–64. http://dx.doi.org/10.2979/hyp.1996.11.3.161.
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Bauer, Nancy. "Margaret A. Simons, Feminist Interpretations of Simone de Beauvoir. University Park, PA, Pennsylvania State University Press, 1995." Hypatia 11, no. 3 (1996): 161–64. http://dx.doi.org/10.1111/j.1527-2001.1996.tb01022.x.
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Chidsey, Thomas, and Hellmut Doelling. "Dead Horse Point, Southeastern Utah." Geosites 1 (March 11, 2020): 1–17. http://dx.doi.org/10.31711/geosites.v1i1.56.
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The Dead Horse Point geosite, within the state park by the same name, is located in the heart of the Canyonlands region of Utah between Canyonlands and Arches National Parks. The views are spectacular, sublime, awe-inspiring, and majestic, and hard to surpass anywhere on the Colorado Plateau. The mood of the vistas changes by season and time of day. Here, one of nature’s engineers, in this instance the Colorado River and its tributaries, has carved and exposed strata of Late Pennsylvanian (307 million years ago [Ma]) to Early Jurassic (200 Ma) age within just the past 5 million years (figures 2 and 3).
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Patel, Archit, Arya Mariam Roy, Malak Alharbi, Kristopher Attwood, Chi-Chen Hong, Song Yao, Thaer Khoury, et al. "Abstract PO5-06-08: Real-world analysis of efficacy, adverse events and predictive biomarkers for advanced triple negative breast cancer (TNBC) treated with immune check point Inhibitors (ICI): A single center experience." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO5–06–08—PO5–06–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-06-08.
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Abstract Introduction KEYNOTE-355 investigated the addition of pembrolizumab to chemotherapy in advanced TNBC patients (pts) with PD-L1 positive tumors showing median overall survival (OS) of 23.0 months (mos) and median progression-free survival (PFS) of 16.1 mos. Given significant OS benefit with pembrolizumab, it is the current standard of care while the indication of atezolizumab has been withdrawn due to lack of OS benefit in IMPASSION-130. Clinical efficacy and adverse events in pts on this treatment regimen in clinical practice is unknown and understanding the real-world outcomes of this regimen is critical. Methods We conducted a retrospective, single-center observational study among TNBC pts treated with ICI (Pembrolizumab or Atezolizumab) at Roswell Park Comprehensive Cancer Center from January 2017 to May 2023. Demographics and clinicopathological variables were collected including comorbidities, laboratory data, sites of metastases (mets), treatment received, immune related adverse events (irAEs), and clinical outcomes. Adverse events were reported using the Common Terminology Criteria for Adverse Events v5.0. Serial CT scans were reviewed and response rate was determined using RECIST v1.1. Patient demographic, clinical and outcome characteristics were summarized by treatment and survival outcomes were obtained using standard Kaplan-Meier methods. Associations between survival outcomes and baseline or treatment characteristics were evaluated using Cox regression models using Firth’s method. All analyses were conducted in SAS v9.4 at a significance level of 0.05. Results A total of 44 pts with advanced TNBC treated with ICI were included (23 received pembrolizumab and 21 received Atezolizumab). The study population consisted of all female pts with stage IV disease, median age 53.7 years (IQR 30.4-85.2), 68.2 % (30/44) White, 25.0% (11/44) Black, 34.1% (15/44) obese (BMI≥30). 27.3% (12/44) pts developed any grade irAEs which included myocarditis (4.5%), rash (9.1%), hyperthyroidism (6.8%), hypothyroidism (4.5%), adrenal insufficiency (2.3%), diabetes mellitus (2.4%), colitis (2.3%), and transaminitis (2.3%). Distribution of reported irAE was 25% grade 1 (3/12), 66.7% grade 2 (8/12) and 8.3% grade 3 (1/12). 75% pts (33/44) received standard treatment (ICI+ chemotherapy) of which 72.7 % (24/33) received it in the first-line setting. Median OS in pts treated in first line was 16.2 mos (95% CI, 10.7-NR) and median PFS was 4.4 mos (95% CI, 2.7-8.4). Overall response rate (ORR) was 29.1% (7/24) of which 8.3% (2/24) had complete response and 20.8% (5/24) had partial response. ORR was 22.2 % (2/9) in pembrolizumab cohort and 33.3 % (5/15) in atezolizumab cohort. Among pts with first line treatment, obese pts were found to have improved PFS compared to non-obese (11.5 vs 3.8 mos, univariate hazard ratio (HR) 0.46, 95% CI 0.23-0.93, p= 0.031), and this difference was maintained in multivariable analysis even after adjusting for age (adjusted HR (aHR) 0.40, 95% CI 0.17-0.98, p= 0.044). Pts with brain mets had poor extracranial PFS compared to those without brain mets (2.8 vs. 5.2 mos, HR 2.25, 95% CI 1.08-4.68, p= 0.036), however this difference was not observed when further adjusted for age (aHR 2.27, 95% CI= 0.91-5.68, p= 0.08). Conclusion Clinical outcomes in our study were inferior to KEYNOTE-355 where median PFS was 16.1 mos and OS was 23.0 mos and ORR was 52.7% for PD-L1 positive population. This may reflect a more heterogeneous population of pts treated in routine clinical practice who are typically less fit than pts on clinical trials. Our study found improved outcomes among obese patients, similar to data reported in other disease settings. These data warrant multi-center validation with larger number of patients. Citation Format: Archit Patel, Arya Mariam Roy, Malak Alharbi, Kristopher Attwood, Chi-Chen Hong, Song Yao, Thaer Khoury, Amy Early, Tracey O'Connor, Ellis Levine, Shipra Gandhi. Real-world analysis of efficacy, adverse events and predictive biomarkers for advanced triple negative breast cancer (TNBC) treated with immune check point Inhibitors (ICI): A single center experience [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-06-08.
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Rubinstein, Jill Carol, Sergii Domanskyi, Todd B. Sheridan, Brian J. Sanderson, SungHee Park, Jessica Kaster, Haiyin Li, Olga Anczukow, Meenhard Herlyn, and Jeffrey H. Chuang. "Abstract 1164: Spatiotemporal profiling defines persister and resistance signatures in targeted treatment of melanoma." Cancer Research 83, no. 7_Supplement (April 4, 2023): 1164. http://dx.doi.org/10.1158/1538-7445.am2023-1164.
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Abstract Over half of BRAF mutant melanoma patients with response to targeted therapy recur within 15 months. Resistance is postulated to arise from certain clonal populations that enter a slow cycling persister state, evade treatment with relative dormancy, and repopulate the tumor when reactivated. Via longitudinal profiling we define expression states of clonal populations and track their evolutionary progression. BRAF mutant patient derived melanoma xenografts were treated with BRAF/MEK inhibitors through maximum tumor size reduction and re-growth. Spatial transcriptomics (ST) was performed at 5 timepoints across 94 days of treatment, tracking clonal populations with intact tissue structure. Deep learning on H&E-stained images automatically detected histological features that co-localize with expression levels. A novel computational pipeline performed clustering, differential expression and pathway enrichment analysis, copy number variation detection, and pseudotemporal ordering, allowing spatial recreation of clonal phylogenies and cell fate trajectory inference during the treatment course. Three clonal categories were defined; Sensitive: predominant in treatment-naïve samples, Persister: remaining clusters in maximally shrunken specimens, Resistant: re-emergent, fast-proliferating. Analysis of clonal composition identified GAPDH and CCND1 as highly expressed in sensitive clones, suppressed in persisters, and reactivated in resistant clones; TYRP1, DCT, MITF, and NGFR showed an opposite pattern. Persister clones evolved from oxidative phosphorylation toward glycolysis and MAPK regulation. Spatial analysis showed increased glycolysis:oxidative phosphorylation ratio in centrally located sensitive clusters, with more balanced peripheral expression. Resistant clones showed upregulated DUSP6 expression and enrichment in Orexin signaling and MAPK regulation. Imaging- and expression-based clones were highly concordant. Spatial profiling during melanoma treatment identified transient persister and emergent resistant clones, defining expression profiles and phenotypic features. Altered ratio of oxidative to glycolytic metabolic pathways was a hallmark of clonal evolution in both space and time. Specific MAPK pathway re-entry points were identified as candidate resistance mechanisms, suggesting potential therapeutic targets. Deep learning features derived from histological images showed good correlation with ST profiles, providing a promising method for clonal tracking via images alone. This longitudinal experiment mimics a tumor’s clinical course, inducing persistence and resistance via treatment that parallels that seen by patients. Combining ST and imaging techniques, we provide insight into clonal dynamics with novel spatiotemporal resolution, defining an evolutionary roadmap to acquired treatment resistance. Citation Format: Jill Carol Rubinstein, Sergii Domanskyi, Todd B. Sheridan, Brian J. Sanderson, SungHee Park, Jessica Kaster, Haiyin Li, Olga Anczukow, Meenhard Herlyn, Jeffrey H. Chuang. Spatiotemporal profiling defines persister and resistance signatures in targeted treatment of melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1164.
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Sutton, P., R. Meyer, and R. Stalter. "The Vascular Plants of Cape May Point State Park Cape May County, New Jersey." Bulletin of the Torrey Botanical Club 117, no. 3 (July 1990): 294. http://dx.doi.org/10.2307/2996698.
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Carvalho, Joema, Santiago José Elías Velazco, Tiaro Katu Pereira, and Franklin Galvão. "Regeneração natural em povoamentos de Araucaria angustifolia e Pinus sp. em Tunas do Paraná, PR." Pesquisa Florestal Brasileira 36, no. 85 (March 31, 2016): 9. http://dx.doi.org/10.4336/2016.pfb.36.85.892.
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Com o propósito de estudar a regeneração natural em povoamentos de Araucaria angustifolia (PA) e Pinus sp.(PP), sem manejo, nas áreas do Parque Estadual de Campinhos, no Município de Tunas do Paraná, PR, foram instaladas 18 parcelas de 10 m2, 7 para PA e 11 para PP. Amostraram-se todos os indivíduos maiores que 1,5 m de altura, dos quais se mensurou o perímetro à 1,30 m do nível do solo. No PA obteve-se 586 indivíduos, 67 espécies e 29 famílias e no PP foram mensurados 442 indivíduos de 58 espécies e 22 famílias. As espécies mais importantes no PA foram Cordyline spectabilis, Lonchocarpus muehlbergianus e Clethra scabra, e no PP C. spectabilis, Lonchocarpus sp1. e Cupania vernalis. O PA apresentou parâmetros fitossociológicos e diversidade superiores ao PP. A composição florística foi similar em ambos, o que denotou o potencial regenerativo do PP.Natural regeneration under reforestation of Araucaria angustifolia and Pinus sp. in Tunas do Paraná, PR, BrazilThis study aimed to assess the natural regeneration in stands of Araucaria angustifolia (PA) and Pinus sp. (PP) without management in Campinhos State Park, in the Municipality of Tunas do Paraná, Parana State, Brazil. Eighteen plots of 10 m2 were installed, 7 plots for PA and 11 for PP. All trees higher than 1.5 m were sampled and their circumference were measured at 1.30 m above ground level. In PA stand there were 586 individuals, corresponding to 67 species and 29 families and in PP stand 442 individuals of 58 species and 22 families were measured. The most important species in PA were Cordyline spectabilis, Lonchocarpus muehlbergianus and Clethra scabra; and in PP were C. spectabilis, Lonchocarpus sp.1 and Cupania vernalis. PA showed phytosociological parameters and diversity higher than PP. The floristic composition was similar for both stands, which denoted the regenerative potential of PP.Index terms: Native species; Forest plantation; Conservation unit
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FERREIRA, MARIANA NAPOLITANO E., and NATÁLIA COSTA FREIRE. "Community perceptions of four protected areas in the Northern portion of the Cerrado hotspot, Brazil." Environmental Conservation 36, no. 2 (June 2009): 129–38. http://dx.doi.org/10.1017/s0376892909990166.
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SUMMARYEstablishing effective networks of protected areas (PAs) is one of the major goals of conservation strategies worldwide. However, the success of PAs in promoting biodiversity conservation depends on their integration to local and regional contexts, reducing and mitigating human impacts originating from buffer zones. Community perceptions affect interactions between residents and PAs, and thereby conservation effectiveness. Research at Tocantins state (northern Brazilian Cerrado), aimed to analyse local community perceptions of four PAs, discussing how different factors may influence these. Perceptions were assessed through standardized interviews applied to PA employees and 275 local inhabitants. There was modest community participation in PA establishment and management. Residents were aware of the PAs’ existence, but were unfamiliar with their goals. Length of residency and occupation of inhabitants influenced their PA perceptions, shaping different people-park relations in each of the four studied PAs. Involvement of local residents in PA planning and management represents a central strategy to strengthen local support for PAs over the long term. In those areas that still have settlements inside their boundaries, community relocation should follow a careful participatory process to avoid significant changes in local perceptions and attitudes towards these PAs, crucial for conserving Brazilian biodiversity.
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Al-Rbeawi, Salam. "Revisiting Current Techniques for Analyzing Reservoir Performance: A New Approach for Horizontal-Well Pseudosteady-State Productivity Index." SPE Journal 24, no. 01 (August 17, 2018): 71–91. http://dx.doi.org/10.2118/191139-pa.
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Summary The objective of this paper is to revisit currently used techniques for analyzing reservoir performance and characterizing the horizontal-well productivity index (PI) in finite-acting oil and gas reservoirs. This paper introduces a new practical and integrated approach for determining the starting time of pseudosteady-state flow and constant-behavior PI. The new approach focuses on the fact that the derivative of PI vanishes to zero when pseudosteady-state flow is developed. At this point, the derivative of transient-state pressure drop and that of pseudosteady-state pressure drop become mathematically identical. This point indicates the starting time of pseudosteady-state flow as well as the constant value of pseudosteady-state PI. The reservoirs of interest in this study are homogeneous and heterogamous, single and dual porous media, undergoing Darcy and non-Darcy flow in the drainage area, and finite-acting, depleted by horizontal wells. The flow in these reservoirs is either single-phase oil flow or single-phase gas flow. Several analytical models are used in this study for describing pressure and pressure-derivative behavior considering different reservoir configurations and wellbore types. These models are developed for heterogeneous and homogeneous formations consisting of single and dual porous media (naturally fractured reservoirs) and experiencing Darcy and non-Darcy flow. Two pressure terms are assembled in these models; the first pressure term represents the time-dependent pressure drop caused by transient-state flow, and the second pressure term represents time-invariant pressure drop controlled by the reservoir boundary. Transient-state PI and pseudosteady-state PI are calculated using the difference between these two pressures assuming constant wellbore flow rate. The analytical models for the pressure derivatives of these two pressure terms are generated. Using the concept that the derivative of constant PI converges to zero, these two pressure derivatives become mathematically equal at a certain production time. This point indicates the starting time of pseudosteady-state flow and the constant behavior of PI. The outcomes of this study are summarized as the following: Understanding pressure, pressure derivative, and PI behavior of bounded reservoirs drained by horizontal wells during transient- and pseudosteady-state production Investigating the effects of different reservoir configurations, wellbore lengths, reservoir homogeneity or heterogeneity, reservoirs as single or dual porous media, and flow pattern in porous media whether it has undergone Darcy or non-Darcy flow Applying the concept of the PI derivative to determine the starting time of pseudosteady-state stabilized PI The novel points in this study are the following: The derivative of the PI can be used to precisely indicate the starting time of pseudosteady-state flow and the constant behavior of PI. The starting time of pseudosteady-state flow determined by the convergence of transient- and pseudosteady-state pressure derivative or by the PI curve is always less than that determined from the curves of total pressure drop and its derivative. Non-Darcy flow may significantly affect the transient-state PI, but pseudosteady-state PI is slightly affected by non-Darcy flow. The starting time of pseudosteady-state flow is not influenced by non-Darcy flow. The convergence of transient- and pseudosteady-state pressure derivatives is affected by reservoir configurations, wellbore lengths, and porous-media characteristics.
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G, Ganzorig, Enkh-Amgalan G, Аmartuvshin O, Densmaa Sh, and Gantulga Ts. "The valuation of ecosystem services of the Khangain nuruu national park." Mongolian Journal of Agricultural Sciences 22, no. 03 (May 9, 2018): 123–31. http://dx.doi.org/10.5564/mjas.v22i03.960.
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The state protected areas (PAs) lack with financial resource, which weakens the PA management including lack of human resource and their skill development, transparent cooperations, and of equipments and vehicles for ecosystem conservation and rehabilitation activities of the PAs. Thus, research on analysing the economic value of the PAs is vital important for the decision makers and policy planners, because they have lack of understanding of benefits of investing to the PAs. In 2013, United Nations Development Programme published a book that reflects the approach of “Targeted Scenario Analysis”, which is used in our study. The Khangain Nuruu National Park (KNPA) locates in 11 soums of three provinces, namely Arkhangai, Bayankhongor and Uvurkhangai, and we analyzed economic value of the KNPA for six economic sectors (livestock husbandry, crop farming, forestry, tourism, mining and industry), and two non-economic but consumption based sectors (carbon sequestration from larch trees, and drinkable water). The economic value or the contribution to the economy of Mongolia from KNPA was about MNT 165.4 billion in 2014, and it summed up to MNT 1 trillion between 2002 and 2014. Livestock husbandry, mining and tourism sectors benefitted about two third of this value. In case of “Business As Usual-BAU” scenario takes, continuesly, in place the total economic loss would reach to MNT 1.4 trillion between 2015 and 2040, compared to “Investing in Natural Capital-INC” scenario. Hence, implementing INC in the KNPA management would save this loss. We recommend to increase the financial resources for the KNPA management, therefore the economic sectors will not diminish due to lack of ecosystem services of the PA, which would then develop the sectors in the long run sustainably.
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Drapac, Vesna. "The End of Yugoslavia." Contemporary European History 10, no. 2 (July 2001): 317–31. http://dx.doi.org/10.1017/s0960777301002089.
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Francine Friedman, The Bosnian Muslims: Denial of a Nation (Colorado: Westview Press, 1996), 288 pp., $35.00, ISBN 0-8133-2096-8. Eric D. Gordy, The Culture of Power in Serbia: Nationalism and the Destruction of Alternatives (University Park, PA: Pennsylvania State University Press, 1999), 230 pp., $17.95, ISBN 0-271-01958-1. Lorraine M. Lees, Keeping Tito Afloat: The United States, Yugoslavia, and the Cold War (University Park, PA: Pennsylvania State University Press, 1997), 246 pp., $40, ISBN 0-271-01629-9. Reneo Lukic and Allen Lynch, Europe from the Balkans to the Urals: The Disintegration of Yugoslavia and the Soviet Union (Oxford: Oxford University Press and Stockholm International Peace Research Institute Monographs, 1996), 436 pp., £35.00, ISBN 0-19-829200-7. Viktor Meier, Yugoslavia: A History of its Demise, trans. Sabrina Petra Ramet (London and New York: Routledge, 1999), 279 pp., £16.99, ISBN 0-415-18596-3. Aleksandar Pavkovic, The Fragmentation of Yugoslavia: Nationalism and War in the Balkans, 2nd edn (London and New York: Macmillan and St. Martin's Press, 2000), 243 pp., £42.50, ISBN 0-312-23084-2. Sabrina Petra Ramet, Balkan Babel: The Disintegration of Yugoslavia from the Death of Tito to Ethnic War, 2nd edn (Boulder, CO: Westview Press, 1996), 354 pp., $30.00, ISBN 0-8133-2559-5. Richard H. Ullman, ed., The World and Yugoslavia's Wars (New York: Council on Foreign Relations, 1996), 230 pp., $18.95, ISBN 0-87609-191-5. Susan L. Woodward, Balkan Tragedy: Chaos and Dissolution after the Cold War (Washington, DC: Brookings Institution, 1995), 536 pp., $16.95, ISBN 0-8157-9513-0.
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McGowen, Pat, and Rebecca Gleason. "Evaluation of Non-Motorized Use in Grand Teton National Park Phase II: Post Pathway Construction 2012." UW National Parks Service Research Station Annual Reports 34 (January 1, 2011): 75–76. http://dx.doi.org/10.13001/uwnpsrc.2011.3863.
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The 2006 Transportation Plan for Grand Teton National Park proposed 22.5 miles of multi-use pathways outside the road to enhance safety and mobility for travelers using non-motorized modes of transportation in the most visited and developed areas of the park. (Grand Teton National Park Transportation Plan 2006, 2007). Construction of the Phase I Pathway, a 7.7-mile segment between Dornanâs Junction and South Jenny Lake Junction along Teton Park Road began in June 2008 (Figure 1). This report summarizes research conducted by the Western Transportation Institute at Montana State University before and after this construction occurred. Researchers counted non-motorized travelers, primarily bicyclists and pedestrians, and administered surveys to learn about visitor perceptions regarding the conditions for non-motorized travel in the park. The primary purpose of this research was to compare the conditions before and after Phase I Pathway was constructed. These results also offer a âpoint-in-timeâ glimpse of current non-motorized usage of this region of the park.
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Matheson, David. "Legal Argumentation and EvidenceDouglas N. Walton University Park, PA: Pennsylvania State University Press, 2002, xvii + 374 pp., $65.00." Dialogue 43, no. 3 (2004): 607–9. http://dx.doi.org/10.1017/s0012217300003140.
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Stanlick, Nancy A. "Feminist Interpretations of Mary Wollstonecraft. By Maria J. Falco. University Park, PA: The Pennsylvania State University Press, 1996." Hypatia 12, no. 1 (1997): 179–82. http://dx.doi.org/10.1111/j.1527-2001.1997.tb00177.x.
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Mutter, Robert, Tina Hieken, Todd DeWees, Arslan Afzal, Stephanie Kenison, Laura Vallow, Christopher Deufel, et al. "Abstract PD7-03: Ultra-accelerated photon, proton, and brachytherapy partial breast irradiation: Primary results of the Mayo 3-fraction trial." Cancer Research 82, no. 4_Supplement (February 15, 2022): PD7–03—PD7–03. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd7-03.
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Abstract Background: Partial breast irradiation (PBI) is an established option for selected patients with early stage breast cancer. The optimal technique, target volume and dose/fractionation for PBI has yet to be defined. The most studied regimen in North America (38.5 Gy in 10 fractions twice daily) has been associated with cosmetic deterioration. We hypothesized that condensing treatment and reducing the total administered dose could improve the therapeutic ratio in luminal breast cancer and DCIS based on emerging evidence that breast cancer is more sensitive than surrounding normal tissues to high dose fractions. Herein, we report cosmetic, tolerability, disease control, and patient reported outcomes of a novel ultra-accelerated PBI regimen. Methods: We conducted a single arm, three cohort trial of photon, proton, and brachytherapy PBI. Technique was selected at physician and patient discretion. Eligible women were age ≥ 50 years with estrogen receptor positive (ER+), sentinel lymph node negative invasive or in-situ breast cancer measuring ≤ 2.5 cm. The regimen was designed to have comparable biologically equivalent effect as 40 Gy in 15 fractions, assuming an α/β ratio of 3.5. Intracavitary brachytherapy target volume was lumpectomy cavity plus 1 cm and prescribed 21 Gy in 3 fractions. Photon and proton target volumes were post-operative tumor bed plus 1 cm and a 3 mm setup uncertainty margin, prescribed 21.9 Gy (RBE) in 3 fractions, and delivered with image guidance. The primary outcome was the percentage difference in patients with adverse cosmesis (defined as fair or poor cosmesis) at 3 years compared to baseline pre-PBI, as assessed by trained nurses using the 4-point Harvard breast cosmesis scale. Patients also completed quality of life surveys and self-reported cosmesis using the 4-point scale. Locoregional and distant recurrence-free survival was determined using the Kaplan-Meier method. Adverse events were assessed using CTCAE, v 4.0. Results: Between 2015 and 2017, 163 patients were treated: photons in 58, protons in 48, and brachytherapy in 57. Median patient age was 66 years. 129 (79%) patients had invasive breast cancer (all ER+) and 34 (21%) had DCIS (83% ER+). Median tumor size was 1.1 cm. Grade was 2-3 in 102 (63%). The median mean heart/ipsilateral lung doses were photons 0.1/1.6 Gy, protons <0.001/0.1 Gy, and brachytherapy 0.5/0.9 Gy. Median follow-up was 4.1 years (IQR 3.9-5.0). The proportion of patients with adverse cosmesis (by RN assessment) was 14.3% at baseline and 3.8% at 3 years, with four patients (1 photon, 1 proton, 2 brachytherapy) experiencing cosmetic deterioration at 3 years from baseline. The proportion with adverse cosmesis by self-report at 3 years was 2.4%, with three patients (1 photon, 1 proton, 1 brachytherapy) reporting cosmetic deterioration. Four patients developed locoregional recurrence (1 photons, 2 protons, 1 brachytherapy); three were local only and one was local and distant. 4-year locoregional recurrence and distant metastasis-free survival were 97.9% and 97.4%, respectively. There were 2 treatment related ≥ grade 2 late events (grade 2 fibrosis and grade 2 seroma, both brachytherapy associated), and no evidence of deterioration in patient-reported pain, fatigue, breast related or overall quality of life, as assessed by the patient reported outcomes version of the CTCAE, 10-point linear analog scales, and the breast cancer treatment outcomes scale. Conclusions: Ultra-accelerated 3-fraction PBI exquisitely spared normal tissues and was associated with favorable cosmetic outcomes, disease control, and excellent long-term tolerability. This ‘precision-radiotherapy’ approach may optimize the therapeutic ratio over more aggressive radiotherapy options as well as radiotherapy omission, particularly in patients with long life expectancies. Citation Format: Robert Mutter, Tina Hieken, Todd DeWees, Arslan Afzal, Stephanie Kenison, Laura Vallow, Christopher Deufel, Nicholas Remmes, Kathryn Ruddy, Judy Boughey, Keith Furutani, Amy Degnim, James Jakub, Tamara Vern-Gross, Dean Shumway, William Wong, Samir Patel, Lisa McGee, Minetta Liu, Carlos Vargas, Daniel Visscher, Bradley Stish, Deanna Pafundi, Mark Waddle, Michael Golafshar, Michele Halyard, Kimberly Corbin, Sean Park. Ultra-accelerated photon, proton, and brachytherapy partial breast irradiation: Primary results of the Mayo 3-fraction trial [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD7-03.
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Ghosh, Karthik, Sarah Jenkins, Jennifer Ridgeway, Jessica D. Austin, Bijan Borah, Bhavika K. Patel, Deborah Rhodes, et al. "Abstract P6-05-38: Breast Density Notification: Impact on anxiety, breast cancer worry, and self-perceived risk among Latinas at a federally qualified medical center." Cancer Research 83, no. 5_Supplement (March 1, 2023): P6–05–38—P6–05–38. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-05-38.
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Abstract Mammographic breast density (MBD) has been shown to be a strong, independent risk factor for breast cancer (BC) irrespective of race/ethnicity. Given the risk association of MBD and its potential to mask tumors on a mammogram, state and federal laws have mandated that women receive information regarding their personal MBD in their mammography reports. However, concerns have been raised regarding the impact of MBD notification on patient anxiety, especially written information for women who experience health disparities such as racial/ethnic minorities, lower health literacy, limited English proficiency and lower socioeconomic status. We performed a randomized controlled clinical trial to examine the impact of three different written and interpersonal approaches to MBD notification on patient anxiety, BC worry, and self-perceived BC risk, among Latinas receiving routine mammography screening at a federally qualified medical center (FQHC). We hypothesized that interpersonal education would reduce anxiety and worry, relative to the written notifications alone. The study was performed at the Baseline Clinic of Mountain Park Health Center, a FQHC in Phoenix, AZ. Women between ages 40 and 74 years presenting for screening mammogram were eligible. After providing signed informed consent, participants were randomized equally to usual care (UC- mailed notification letter); enhanced care (notification letter and MBD educational brochure designed for this study): interpersonal care (notification letter, brochure, promotora education via telephone). A stratified block randomization procedure was used with age > 50 years (yes vs no), ethnicity (Hispanic vs non-Hispanic), and language preference (Spanish vs. English) as strata. Study participants completed surveys at the time of enrollment/pre-intervention (T0), at two weeks to six months after intervention was delivered (T1), and about one year after randomization (T2). Anxiety state was measured using the state anxiety subscale of the State-Trait Anxiety Inventory scale (STAI-S) (range from 20-80). BC worry was probed using the question: “How frequently do you worry about getting breast cancer someday”. The self-perceived lifetime risk of BC was rated between 0% (no chance of BC) to 100% (definitely will get BC). The proportion of participants with an increase or persistence of higher level for each outcome between time points was compared between the three study groups. The study was approved by the Mayo Clinic Institutional Review Board. 1332 Latina women were enrolled and randomized between October 2016 and October 2019. All completed the baseline (T0) survey, 928 completed T1, 632 completed T2, and 516 completed both T1 and T2 surveys. At study entry, majority of the participants were young (64.1% between age 40-49 years), had no family history of breast cancer (81.0%), had less than high school education (68.8%), and were married or partnered (67.8%). At T0, the mean (SD) anxiety STAI score was 32.5 (11.1); 51.8% with moderate or severe anxiety (score > 30). With regard to BC worry, 41.3% reported worrying “sometimes”, “often”, or “almost all the time”. Further, 25.4% reported a self-perceived lifetime risk of developing BC of >10% while only 6.6% had a Gail model estimated lifetime risk score of >10%. There was no significant difference in changes in anxiety, BC worry or self-perceived risk from T0 to either T1 or T2 surveys between the intervention groups. In summary, this study found high levels of baseline anxiety and BC worry (despite the majority being 40-49 years old and having no family history of BC) which persisted regardless of how notification and education were delivered. Future work is needed to improve the understanding of factors that could lower anxiety and BC worry and improve risk perception in this population. Citation Format: Karthik Ghosh, Sarah Jenkins, Jennifer Ridgeway, Jessica D. Austin, Bijan Borah, Bhavika K. Patel, Deborah Rhodes, Aaron Norman, Edna P. Ramos, Matt Jewett, Crystal Gonzalez, Valentina Hernandez, Davinder Singh, Vera Suman, Celine Vachon. Breast Density Notification: Impact on anxiety, breast cancer worry, and self-perceived risk among Latinas at a federally qualified medical center. [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P6-05-38.
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Danik, Yulia, and Mikhail Dmitriev. "Symbolic Regulator Sets for a Weakly Nonlinear Discrete Control System with a Small Step." Mathematics 10, no. 3 (February 2, 2022): 487. http://dx.doi.org/10.3390/math10030487.
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For a class of discrete weakly nonlinear state-dependent coefficient (SDC) control systems, a suboptimal synthesis is constructed over a finite interval with a large number of steps. A one-point matrix Padé approximation (PA) of the solution of the initial problem for the discrete matrix Riccati equation is constructed based on the state-dependent Riccati equation (SDRE) approach and the asymptotics by the small-step of the boundary layer functions method. The symmetric gain coefficients matrix for Padé control synthesis is constructed based on the one-point PA. As a result, the parametric closed-loop control is obtained. The results of numerical experiments illustrate, in particular, the improved extrapolation properties of the constructed regulator, which makes the algorithm applicable in control systems for a wider range of parameter variation.