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Roceto, Ligia dos Santos, Fernanda Diorio Masi Galhardo, Ivete Alonso Bredda Saad, and Ivan Felizardo Contrera Toro. "Continuous positive airway pressure (CPAP) after lung resection: a randomized clinical trial." Sao Paulo Medical Journal 132, no. 1 (2014): 41–47. http://dx.doi.org/10.1590/1516-3180.2014.1321525.
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CONTEXT AND OBJECTIVE: Noninvasive mechanical ventilation during the postoperative period (PO) following lung resection can restore residual functional capacity, improve oxygenation and spare the inspiratory muscles. The objective of this study was to assess the efficacy of continuous positive airway pressure (CPAP) associated with physiotherapy, compared with physiotherapy alone after lung resection. DESIGN AND SETTING: Open randomized clinical trial conducted in the clinical hospital of Universidade Estadual de Campinas. METHOD: Sessions were held in the immediate postoperative period (POi) and on the first and second postoperative days (PO1 and PO2), and the patients were reassessed on the discharge day. CPAP was applied for two hours and the pressure adjustment was set between 7 and 8.5 cmH2O. The oxygenation index (OI), Borg scale, pain scale and presence of thoracic drains and air losses were evaluated. RESULTS : There was a significant increase in the OI in the CPAP group in the POi compared to the Chest Physiotherapy (CP) group, P = 0.024. In the CP group the OI was significantly lower on PO1 (P = 0,042), than CPAP group. The air losses were significantly greater in the CPAP group in the POi and on PO1 (P = 0.001, P = 0.028), but there was no significant difference between the groups on PO2 and PO3. There was a statistically significant difference between the groups regarding the Borg scale in the POi (P < 0.001), but there were no statistically significant differences between the groups regarding the pain score. CONCLUSION: CPAP after lung resection is safe and improves oxygenation, without increasing the air losses through the drains. CLINICAL TRIAL REGISTRATION: NCT01285648
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Fanfani, Massimo. "Senno del poi o senno di poi?" XVI, 2021/1 (gennaio-marzo), no. 1 (January 22, 2021): 20–23. http://dx.doi.org/10.35948/2532-9006/2021.5461.
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In questi ultimi tempi diverse persone attente e sensibili ai fatti di lingua si sono rivolte al servizio di Consulenza linguistica dell’Accademia della Crusca per sapere se sia corretto dire col senno del poi, o non piuttosto col senno di poi.
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Cymrot, Moacir, Sandro Percário, and Lydia Masako Ferreira. "Comportamento do estresse oxidativo e da capacidade antioxidante total em ratos submetidos a retalhos cutâneos isquêmicos." Acta Cirurgica Brasileira 19, no. 1 (January 2004): 18–26. http://dx.doi.org/10.1590/s0102-86502004000100003.
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OBJETIVO: Estudar o comportamento do estresse oxidativo (MDA) e da defesa antioxidante (CAT), em fragmentos de retalhos cutâneos randômicos isquêmicos em ratos. MÉTODOS: Foram utilizados 18 ratos adultos jovens, machos (Wistar EPM-1, 290 a 350g), submetidos à elevação de retalho cutâneo de base cranial no dorso, divididos em três grupos (N=6) em função do tempo pós-operatório: imediato (POI), terceiro e sétimo dias (PO3 e PO7, respectivamente). Ao final, foram coletadas amostras de sangue periférico e fragmentos de tecido do retalho e de área cutânea normal fora do retalho para dosagem de MDA e de CAT. RESULTADOS: Para MDA no soro, o grupo POI apresentou valores significativamente menores que os grupos PO3 e PO7, os quais não diferiram entre si. Não foi encontrada diferença entre os valores das amostras cutâneas em nenhum dos três grupos estudados. Para os valores da capacidade antioxidante total (CAT) não houve diferença significante entre os três grupos, quando analisado o soro dos animais, no entanto, para as amostras de fragmentos cutâneos, os valores diminuíram significativamente em função do tempo. CONCLUSÃO: A inexistência de diferença para os valores de MDA nas amostras cutâneas entre os grupos e a diminuição dos valores da CAT ao longo do tempo sugere que a presença de necrose na porção distal dos retalhos dos animais do grupo PO7 decorra, não somente da agressão oxidativa, mas também da diminuição da capacidade de defesa antioxidante local.
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Rodriguez-Monguio, PhD, MS, Rosa, Ellen Berkley, PharmD, Edgardo Mendoza, PharmD, Kirsten Miller, PharmD, Shafat Selim, PharmD, Cindy Trac, PharmD, Zhixin Lun, PhD, and Lori Reisner, PharmD, FCSHP. "Inpatient administration of opioids and risk for post-operative ileus in older adults." Journal of Opioid Management 18, no. 4 (July 1, 2022): 317–25. http://dx.doi.org/10.5055/jom.2022.0727.
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Objective: Post-operative ileus (POI) is a common and potentially serious complication after surgery. We assessed the incidence and identified predictors of POI in older surgical patients.Design: A retrospective observational study.Setting: University of California-San Francisco electronic medical record data.Participants: Opioid-naïve, noncancer patients, aged 65 and older, who underwent elective surgery in the period 2017-2019.Exposure: Administration of opioid analgesics per day of hospitalization in opioid naïve patients.Main outcomes measure: Incidence of POI and likelihood of developing POI.Results: In the study period, 3 percent of opioid naïve patients developed POI. Patients with POI used on average 197.1 oral morphine equivalents (OMEs) per day of hospitalization compared to 82.5 OME in patients without POI (p = 0.013). Yet, there were not statistically significant differences in post-operative pain scores between patients with and without POI. General surgery (p = 0.0031), length of surgery (p = 0.0031), and hospital length of stay (p 0.0001) were significant predictors of the risk for developing POI. Adjusted inpatient administration of more than 90 OME per day of hospitalization was associated with a four times greater risk for developing POI (p = 0.016). Developing POI was associated with 6.5 (95 percent confidence interval: 5.2-7.8) additional days of hospitalization among patients who developed POI compared to patients who did not develop POI (p 0.0001).Conclusions: Adjusted inpatient administration of more than 90 OME significantly increased the risk for developing POI in opioid-naïve older patients. Developing POI after surgery significantly increased the hospital length of stay. Optimizing inpatient administration of opioids may prevent opioid use-related POI and longer hospitalizations.
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Lasmana, Indradhi, and Yohana Milo. "EVALUASI KINERJA JARINGAN IRIGASI AIR TANAH GUNA PENINGKATAN PEMENUHAN KEBUTUHAN AIR IRIGASI PADA DAERAH IRIGASI DI KABUPATEN TIMOR TENGAH UTARA (STUDI KASUS DI KECAMATAN INSANA UTARA)." JUTEKS - Jurnal Teknik Sipil 3, no. 1 (July 15, 2018): 232. http://dx.doi.org/10.32511/juteks.v3i1.195.
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Dalam mencapai ketahanan dan kemandirian pangan melalui peningkatan produksi pangan khususnya beras di Propinsi Nusa Tenggara Timur, pemanfaatan air tanah dapat digunakan sebagai air irigasi di daerah-daerah yang kekurangan air. Seiring dengan waktu pemanfaatannya dan usia guna pada beberapa sumur bor untuk Jaringan irigasi air tanah (JIAT) di Kecamatan Insana Utara kabupaten Timor Tengah Utara, mesin pompa maupun jaringannya mengalami penurunan. Bahkan dibeberapa titik lokasi (banyak sistem jaringan Air Tanah tersebut tidak berfungsi. Perlu dilakukannya evaluasi kinerja jaringan irigasi air tanah guna meningkatkan pemenuhan kebutuhan airi irigasi di Kabupaten Timor Tengah Utara umumnya dan kecamatan Insana Utara khususnya. Penelitian evaluasi kinerja jaringan irigasi air tanah di kabupaten Timor Tengah Utara di lakukan di kecamatan Insana Utara. Terdapat 5 Sumur bor di Kecamatan Insana Utara Kabupaten Timor Tengah Utara yang pemanfaatan untuk Jaringan irigasi air tanah (JIAT) yaitu Sumur POI-90, POI-91, POI-92,POI-93 dan sumur POI-95 dengan total daerah layanan sawah seluas +49 Ha. Dari hasil identifikasi masing-masing sumur tersebut menunjukan 2 sumur (POI-90, POI-92) Rumah pompa dalam kondisi rusak berat, 5 Sumur menunjukkan mesin dan pompa mengalami kerusakan, 3 Sumur (POI-90, POI-91, POI-92) system jaringan pipa mengalami kerusakan termasuk asesoriesnya. Hasil evaluasi penilaian Kinerja jaringan irigasi air tanah (JIAT) yang meliputi komponen (1) prasarana fisik, (2) Produktifitas tanaman, (3) Sarana penunjang, (4) Organisasi personalia, (5) Dokumentasi JIAT (6) Petani Pemakai Air Tanah (P3AT) masing diperoleh : Sumur POI-90 = 35% , POI-91 = 30%, Sumur POI- 92 = 10%, Sumur POI-93 = 31% dan Sumur POI-95 = 32 %. Kriteria yang diperoleh dari 5 sumur bor tersebut menunjukkan kinerja jaringan irigasi air tanah (JIAT) adalah kinerja Buruk/jelek dan perlu perhatian (< 50%). Untuk memenuhi kebutuhan air irigasi pada lahan di masing lokasi perlu dilakukan perbaikan.
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Qu, Xinyu, Xinyan Zhu, Xiongwu Xiao, Huayi Wu, Bingxuan Guo, and Deren Li. "Exploring the Influences of Point-of-Interest on Traffic Crashes during Weekdays and Weekends via Multi-Scale Geographically Weighted Regression." ISPRS International Journal of Geo-Information 10, no. 11 (November 19, 2021): 791. http://dx.doi.org/10.3390/ijgi10110791.
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Some studies on the impact of traditional land use factors on traffic crashes do not take into account the limitations of spatial heterogeneity and spatial scale. To overcome these limitations this study presents a systematic method based on multi-scale geographically weighted regression (MGWR), which considers spatial heterogeneity and spatial scale differences of different influencing factors, to explore the influence of reclassified points-of-interest (POI) on traffic crashes occurring on weekdays and weekends. Experiments were conducted on 442 communities in Hankou, Wuhan, and the performance of the proposed method was compared against traditional methods based on ordinary least squares (OLS), spatial lag model (SLM), spatial error model (SEM), and geographically weighted regression (GWR). The experiments show that the proposed method yielded the best fitness of models and more accurate model results of local coefficient estimates. The highlights of the results are as follows: There are differences in the scale of the predictor variables. Residential POI, scenic POI, and transportation POI have a global effect on traffic crashes. Commercial service POI and industrial POI affects traffic crashes at the regional scale, while public service POI affects crashes at the local scale. The local coefficient estimates from residential POI and scenic POI have little impact on traffic crashes. During weekdays, more transportation POI in the entire study area leads to more traffic crashes. While on weekends, transportation POI has a significant positive effect on crashes only in some communities. The local coefficient estimates for industrial POI vary at different periods. Commercial service POI and public service POI may increase the risk of crashes in some communities, which can be observed on weekdays and weekends. Exploring the influence of POI on traffic crashes at different periods is helpful for traffic management strategies and in reducing traffic crashes.
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Huang, Jianfeng, Yuefeng Liu, Yue Chen, and Chen Jia. "Dynamic Recommendation of POI Sequence Responding to Historical Trajectory." ISPRS International Journal of Geo-Information 8, no. 10 (September 30, 2019): 433. http://dx.doi.org/10.3390/ijgi8100433.
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Point-of-Interest (POI) recommendation is attracting the increasing attention of researchers because of the rapid development of Location-based Social Networks (LBSNs) in recent years. Differing from other recommenders, who only recommend the next POI, this research focuses on the successive POI sequence recommendation. A novel POI sequence recommendation framework, named Dynamic Recommendation of POI Sequence (DRPS), is proposed, which models the POI sequence recommendation as a Sequence-to-Sequence (Seq2Seq) learning task, that is, the input sequence is a historical trajectory, and the output sequence is exactly the POI sequence to be recommended. To solve this Seq2Seq problem, an effective architecture is designed based on the Deep Neural Network (DNN). Owing to the end-to-end workflow, DRPS can easily make dynamic POI sequence recommendations by allowing the input to change over time. In addition, two new metrics named Aligned Precision (AP) and Order-aware Sequence Precision (OSP) are proposed to evaluate the recommendation accuracy of a POI sequence, which considers not only the POI identity but also the visiting order. The experimental results show that the proposed method is effective for POI sequence recommendation tasks, and it significantly outperforms the baseline approaches like Additive Markov Chain, LORE and LSTM-Seq2Seq.
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Zhang, Suzhi, Zijian Bai, Pu Li, and Yuanyuan Chang. "Multi-Graph Convolutional Network for Fine-Grained and Personalized POI Recommendation." Electronics 11, no. 18 (September 19, 2022): 2966. http://dx.doi.org/10.3390/electronics11182966.
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With the advent of the era of rapid information expansion, the massive data backlog that exists on the Internet has led to a serious information overload problem, which makes recommendation systems a crucial part of human life. In particular, the Point-Of-Interest (POI) recommendation system has been applied to many real-life scenarios, such as life services and autonomous driving. Specifically, the goal of POI recommendation is to recommend locations that match their personalized preferences to users. In existing POI recommendation methods, people tend to pay more attention to the impact of temporal and spatial factors of POI on users, which will alleviate the problems of data sparsity and cold start in POI recommendation. However, this tends to ignore the differences among individual users, and considering only temporal and spatial attributes does not support fine-grained POI recommendations. To solve this problem, we propose a new Fine-grained POI Recommendation With Multi-Graph Convolutional Network (FP-MGCN). This model focuses on the content representation of POIs, captures users’ personalized preferences using semantic information from user comments, and learns fine-grained representations of users and POIs through the relationships between content–content, content–POI, and POI–user. FP-MGCN employs multiple embedded propagation layers and adopts information propagation mechanisms to model the higher-order connections of different POI-related relations for enhanced representation. Fine-grained POI is finally recommended to users through the three types of propagation we designed: content–content information propagation, content–POI information propagation, and POI–user information propagation. We have conducted detailed experiments on two datasets, and the results show that FP-MGCN has advanced performance and can alleviate the data sparsity problem in POI recommendation tasks.
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Brozzetti, Annalisa, Mohammad Alimohammadi, Silvia Morelli, Viviana Minarelli, Åsa Hallgren, Roberta Giordano, Annamaria De Bellis, Roberto Perniola, Olle Kämpe, and Alberto Falorni. "Autoantibody Response Against NALP5/MATER in Primary Ovarian Insufficiency and in Autoimmune Addison's Disease." Journal of Clinical Endocrinology & Metabolism 100, no. 5 (May 1, 2015): 1941–48. http://dx.doi.org/10.1210/jc.2014-3571.
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Abstract Context: NACHT leucine-rich-repeat protein 5 (NALP5)/maternal antigen that embryo requires (MATER) is an autoantigen in hypoparathyroidism associated with autoimmune polyendocrine syndrome type 1 (APS1) but is also expressed in the ovary. Mater is an autoantigen in experimental autoimmune oophoritis. Objectives: The objectives of the study were to determine the frequency of NALP5/MATER autoantibodies (NALP5/MATER-Ab) in women with premature ovarian insufficiency (POI) and in patients with autoimmune Addison's disease (AAD) and to evaluate whether inhibin chains are a target for autoantibodies in POI. Methods: Autoantibodies against NALP5/MATER and inhibin chains-α and -βA were determined by radiobinding assays in 172 patients with AAD without clinical signs of gonadal insufficiency, 41 women with both AAD and autoimmune POI [steroidogenic cell autoimmune POI (SCA-POI)], 119 women with idiopathic POI, 19 patients with APS1, and 211 healthy control subjects. Results: NALP5/MATER-Ab were detected in 11 of 19 (58%) sera from APS1 patients, 12 of 172 (7%) AAD sera, 5 of 41 (12%) SCA-POI sera, 0 of 119 idiopathic POI sera and 1 of 211 healthy control sera (P < .001). None of 160 POI sera, including 41 sera from women with SCA-POI and 119 women with idiopathic POI, and none of 211 healthy control sera were positive for inhibin chain-α/βA autoantibodies. Conclusions: NALP5/MATER-Ab are associated with hypoparathyroidism in APS1 but are present also in patients with AAD and in women with SCA-POI without hypoparathyroidism. Inhibin chains do not appear to be likely candidate targets of autoantibodies in human POI.
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Umair, Zobia, Mi-Ock Baek, Jisue Song, Seona An, Seung Joo Chon, and Mee-Sup Yoon. "MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency." Cells 11, no. 18 (September 7, 2022): 2797. http://dx.doi.org/10.3390/cells11182797.
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Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea that lasts for a minimum of four months in women < 40 years old and is typically characterized by reduced estrogen levels and elevated serum concentrations of follicle-stimulating hormone. We collected urine samples from two participant cohorts from Gil Hospital of Gachon University (Incheon, Korea): a sequencing cohort of 19 participants (seven patients with POI (POI patients without Turner syndrome), seven patients with Turner syndrome (POI patients with Turner syndrome), and five control individuals (age-matched controls with confirmed ovarian sufficiency)) and a validation cohort of 46 participants (15 patients with POI, 11 patients with Turner syndrome, and 20 control individuals). Among differentially expressed miRNAs, hsa-miR-4516 was significantly upregulated in patients with POI in both cohorts, independent of the presence of Turner syndrome. Moreover, the upregulation of miR-4516 was confirmed in the ovary—but not in the uterus—of a cyclophosphamide and busulfan-induced POI mouse model. This was accompanied by a decrease in STAT3 protein level, a predicted target of miR-4516, via miRTarBase2020. Our study provides compelling evidence that miR-4516 is highly expressed in patients with POI and POI mouse models, suggesting that miR-4516 is a diagnostic marker of POI.
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Low, Raymond, Zeynep Duygu Tekler, and Lynette Cheah. "An End-to-End Point of Interest (POI) Conflation Framework." ISPRS International Journal of Geo-Information 10, no. 11 (November 15, 2021): 779. http://dx.doi.org/10.3390/ijgi10110779.
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Point of interest (POI) data serves as a valuable source of semantic information for places of interest and has many geospatial applications in real estate, transportation, and urban planning. With the availability of different data sources, POI conflation serves as a valuable technique for enriching data quality and coverage by merging the POI data from multiple sources. This study proposes a novel end-to-end POI conflation framework consisting of six steps, starting with data procurement, schema standardisation, taxonomy mapping, POI matching, POI unification, and data verification. The feasibility of the proposed framework was demonstrated in a case study conducted in the eastern region of Singapore, where the POI data from five data sources was conflated to form a unified POI dataset. Based on the evaluation conducted, the resulting unified dataset was found to be more comprehensive and complete than any of the five POI data sources alone. Furthermore, the proposed approach for identifying POI matches between different data sources outperformed all baseline approaches with a matching accuracy of 97.6% with an average run time below 3 min when matching over 12,000 POIs to result in 8699 unique POIs, thereby demonstrating the framework’s scalability for large scale implementation in dense urban contexts.
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Brozzetti, Annalisa, Stefania Marzotti, Daria La Torre, Maria Luisa Bacosi, Silvia Morelli, Vittorio Bini, Bruno Ambrosi, et al. "Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response." European Journal of Endocrinology 163, no. 2 (August 2010): 309–17. http://dx.doi.org/10.1530/eje-10-0257.
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ObjectiveSteroid-producing cell autoantibodies (SCAs) directed against 21-hydroxylase autoantibodies (21OHAbs), 17α-hydroxylase autoantibodies (17OHAb), and cholesterol side-chain cleavage enzyme (side-chain cleavage autoantibodies, P450sccAb) characterize autoimmune primary ovarian insufficiency (SCA-POI). The aim of the study was to analyze IgG subclass specificity of autoantibodies related to adrenal and ovarian autoimmunity.DesignWe studied 29 women with SCA-POI, 30 women with autoimmune Addison's disease (AAD) without POI, and 14 patients with autoimmune polyendocrine syndrome type 1 (APS1). 21OHAb isotypes were also analyzed in 14 subjects with preclinical AAD. Samples from 30 healthy women served as control group to determine the upper level of normality in the isotype assays.MethodsImmunoradiometric assays with IgG subclass-specific secondary antibodies.ResultsIn 21OHAb-positive sera, IgG1 isotype was detected in 90% SCA-POI and non-POI AAD sera and 67% APS1 patients. IgG1 isotype was found in 69% 17OHAb-positive SCA-POI and 100% 17OHAb-positive APS1 sera, and in 60% P450sccAb-positive SCA-POI and 80% P450sccAb-positive APS1 sera. For 21OHAb, IgG4 isotype was detected in 17% SCA-POI, 7% non-POI AAD, and 8% APS1 sera. None of the 17OHAb-positive sera was positive for IgG4. In P450sccAb-positive sera, 15% POI and 20% APS1 sera were positive for IgG4. Two 21OHAb-positive SCA-POI (7%), one 21OHAb-positive AAD (3%), three P450sccAb-positive SCA-POI (15%), and two P450sccAb-positive APS1 (20%) sera were positive for IgG4, in the absence of IgG1. All preclinical AAD sera resulted as positive for IgG1-21OHAb, but not for IgG4-21OHAb.ConclusionsThe autoantibody responses in POI and AAD are IgG1 dominated, which suggests a predominant Th1 response. Selective IgG4 isotype specificity identified a small subset of patients with Th2-oriented response.
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Tiosano, Dov, Jason A. Mears, and David A. Buchner. "Mitochondrial Dysfunction in Primary Ovarian Insufficiency." Endocrinology 160, no. 10 (August 8, 2019): 2353–66. http://dx.doi.org/10.1210/en.2019-00441.
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Abstract Primary ovarian insufficiency (POI) is defined by the loss or dysfunction of ovarian follicles associated with amenorrhea before the age of 40. Symptoms include hot flashes, sleep disturbances, and depression, as well as reduced fertility and increased long-term risk of cardiovascular disease. POI occurs in ∼1% to 2% of women, although the etiology of most cases remains unexplained. Approximately 10% to 20% of POI cases are due to mutations in a single gene or a chromosomal abnormality, which has provided considerable molecular insight into the biological underpinnings of POI. Many of the genes for which mutations have been associated with POI, either isolated or syndromic cases, function within mitochondria, including MRPS22, POLG, TWNK, LARS2, HARS2, AARS2, CLPP, and LRPPRC. Collectively, these genes play roles in mitochondrial DNA replication, gene expression, and protein synthesis and degradation. Although mutations in these genes clearly implicate mitochondrial dysfunction in rare cases of POI, data are scant as to whether these genes in particular, and mitochondrial dysfunction in general, contribute to most POI cases that lack a known etiology. Further studies are needed to better elucidate the contribution of mitochondria to POI and determine whether there is a common molecular defect in mitochondrial function that distinguishes mitochondria-related genes that when mutated cause POI vs those that do not. Nonetheless, the clear implication of mitochondrial dysfunction in POI suggests that manipulation of mitochondrial function represents an important therapeutic target for the treatment or prevention of POI.
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Tucker, Elena J., Sonia R. Grover, Anne Bachelot, Philippe Touraine, and Andrew H. Sinclair. "Premature Ovarian Insufficiency: New Perspectives on Genetic Cause and Phenotypic Spectrum." Endocrine Reviews 37, no. 6 (October 3, 2016): 609–35. http://dx.doi.org/10.1210/er.2016-1047.
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Abstract Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of ovarian activity before the age of 40 and characterized by amenorrhea (primary or secondary) with raised gonadotropins and low estradiol. POI affects up to one in 100 females, including one in 1000 before the age of 30. Substantial evidence suggests a genetic basis for POI; however, the majority of cases remain unexplained, indicating that genes likely to be associated with this condition are yet to be discovered. This review discusses the current knowledge of the genetic basis of POI. We highlight genes typically known to cause syndromic POI that can be responsible for isolated POI. The role of mouse models in understanding POI pathogenesis is discussed, and a thorough list of candidate POI genes is provided. Identifying a genetic basis for POI has multiple advantages, such as enabling the identification of presymptomatic family members who can be offered counseling and cryopreservation of eggs before depletion, enabling personalized treatment based on the cause of an individual's condition, and providing better understanding of disease mechanisms that ultimately aid the development of improved treatments.
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Bouilly, Justine, Isabelle Beau, Sara Barraud, Valérie Bernard, Kemal Azibi, Jérôme Fagart, Anne Fèvre, et al. "Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency." Journal of Clinical Endocrinology & Metabolism 101, no. 12 (September 7, 2016): 4541–50. http://dx.doi.org/10.1210/jc.2016-2152.
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Context: Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and infertility. POI affects 1% of women before age 40 years, and several genetic causes have been reported. To date, POI has been considered a monogenic disorder. Objective: The aim of this study was to identify novel gene variations and to investigate if individuals with POI harbor mutation in multiple loci. Patients and Methods: One hundred well-phenotyped POI patients were systematically screened for variants in 19 known POI loci (and potential candidate genes) using next-generation sequencing. Results: At least one rare protein-altering gene variant was identified in 19 patients, including missense mutations in new candidate genes, namely SMC1β and REC8 (involved in the cohesin complex) and LHX8, a gene encoding a transcription factor. Novel or recurrent deleterious mutations were also detected in the known POI candidate genes NOBOX, FOXL2, SOHLH1, FIGLA, GDF9, BMP15, and GALT. Seven patients harbor mutations in two loci, and this digenicity seems to influence the age of symptom onset. Conclusions: Genetic anomalies in women with POI are more frequent than previously believed. Digenic findings in several cases suggest that POI is not a purely monogenic disorder and points to a role of digenicity. The genotype-phenotype correlations in some kindreds suggest that a synergistic effect of several mutations may underlie the POI phenotype.
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Vogt, Elinor C., Lars Breivik, Ellen C. Røyrvik, Marianne Grytaas, Eystein S. Husebye, and Marianne Øksnes. "Primary Ovarian Insufficiency in Women With Addison’s Disease." Journal of Clinical Endocrinology & Metabolism 106, no. 7 (March 4, 2021): e2656-e2663. http://dx.doi.org/10.1210/clinem/dgab140.
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Abstract Context Primary ovarian insufficiency (POI) is defined by menopause before 40 years of age. POI prevalence is higher among women with autoimmune Addison’s disease (AAD) than in the general population, but their clinical characteristics are insufficiently studied. Objective To assess the prevalence of POI in a large cohort of women with AAD and describe clinical, immunological, and genetic characteristics. Methods An observational population-based cohort study of the Norwegian National Addison Registry. The Norwegian Prescription Database was used to assess prescription of menopausal hormone replacement therapy (HRT). A total of 461 women with AAD were studied. The primary outcome measure was prevalence of POI. Secondary outcomes were clinical characteristics, autoantibodies, and genome-wide single nucleotide polymorphism variation. Results The prevalence of POI was 10.2% (47/461) and one-third developed POI before 30 years of age. POI preceded or coincided with AAD diagnosis in more than half of the women. The prevalence of concomitant autoimmune diseases was 72%, and AAD women with POI had more autoantibodies than AAD women without (≥2 autoantibodies in 78% vs 25%). Autoantibodies against side-chain cleavage enzyme (SCC) had the highest accuracy with a negative predictive value for POI of 96%. HRT use was high compared to the age adjusted normal population (11.3 % vs 0.7%). Conclusion One in 10 women with AAD have POI. Autoantibodies against SCC are the most specific marker for autoimmune POI. We recommend testing women with AAD <40 years with menstrual disturbances or fertility concerns for autoantibodies against SCC.
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Schmidt, Peter J., Jamie A. Luff, Nazli A. Haq, Vien H. Vanderhoof, Deloris E. Koziol, Karim A. Calis, David R. Rubinow, and Lawrence M. Nelson. "Depression in Women with Spontaneous 46, XX Primary Ovarian Insufficiency." Endocrinology 151, no. 12 (December 1, 2010): 5972. http://dx.doi.org/10.1210/endo.151.12.9992.
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Context: A high prevalence of depressive symptoms is observed in women with primary ovarian insufficiency (POI) compared with women in whom the menopause is normally timed. Indeed, studies suggest that depression and/or its pharmacological treatment contribute to the onset of POI. Objectives: We characterize the prevalence of psychiatric disorders and the timing of onset of clinically significant depression relative to both the diagnosis of POI and the onset of menstrual irregularity in women with POI. Design and Setting: We conducted a cross-sectional clinic-based study at the National Institutes of Health Clinical Research Center. Patients: A total of 174 women with spontaneous 46, XX POI and 100 women with Turner syndrome participated in the study. Main Outcome Measures: The structured clinical interview for DSM-IV was performed. Results: Lifetime histories of depression in POI exceeded rates of depression reported in women with Turner syndrome and community-based samples of women (P < 0.001). The onset of depression frequently preceded the diagnosis of POI but occurred after the onset of menstrual irregularity. Analyses standardizing the periods of risk for depression showed that similar numbers of depressions occurred before and after these events. Conclusions: POI is associated with an increased lifetime risk for major depression. Attention to the presence of depression in POI should become an important part of the care for these women. The onset of depression frequently occurs after signs of altered ovarian function but before the diagnosis of POI. Thus, in some women the association between POI and depression suggests an overlapping pathophysiology rather than a causal relationship.
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Schmidt, Peter J., Jamie A. Luff, Nazli A. Haq, Vien H. Vanderhoof, Deloris E. Koziol, Karim A. Calis, David R. Rubinow, and Lawrence M. Nelson. "Depression in Women with Spontaneous 46, XX Primary Ovarian Insufficiency." Endocrine Reviews 31, no. 6 (December 1, 2010): 944–45. http://dx.doi.org/10.1210/edrv.31.6.9990.
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Context A high prevalence of depressive symptoms is observed in women with primary ovarian insufficiency (POI) compared with women in whom the menopause is normally timed. Indeed, studies suggest that depression and/or its pharmacological treatment contribute to the onset of POI. Objectives We characterize the prevalence of psychiatric disorders and the timing of onset of clinically significant depression relative to both the diagnosis of POI and the onset of menstrual irregularity in women with POI. Design and Setting We conducted a cross-sectional clinic-based study at the National Institutes of Health Clinical Research Center. Patients A total of 174 women with spontaneous 46, XX POI and 100 women with Turner syndrome participated in the study. Main Outcome Measures The structured clinical interview for DSM-IV was performed. Results Lifetime histories of depression in POI exceeded rates of depression reported in women with Turner syndrome and community-based samples of women (P < 0.001). The onset of depression frequently preceded the diagnosis of POI but occurred after the onset of menstrual irregularity. Analyses standardizing the periods of risk for depression showed that similar numbers of depressions occurred before and after these events. Conclusions POI is associated with an increased lifetime risk for major depression. Attention to the presence of depression in POI should become an important part of the care for these women. The onset of depression frequently occurs after signs of altered ovarian function but before the diagnosis of POI. Thus, in some women the association between POI and depression suggests an overlapping pathophysiology rather than a causal relationship.
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Zhao, Ji, Dan Peng, Chuhan Wu, Huan Chen, Meiyu Yu, Wanji Zheng, Li Ma, Hua Chai, Jieping Ye, and Xiaohu Qie. "Incorporating Semantic Similarity with Geographic Correlation for Query-POI Relevance Learning." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 1270–77. http://dx.doi.org/10.1609/aaai.v33i01.33011270.
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Point-of-interest (POI) retrieval that searches for relevant destination locations plays a significant role in on-demand ridehailing services. Existing solutions to POI retrieval mainly retrieve and rank POIs based on their semantic similarity scores. Although intuitive, quantifying the relevance of a Query-POI pair by single-field semantic similarity is subject to inherent limitations. In this paper, we propose a novel Query-POI relevance model for effective POI retrieval for ondemand ride-hailing services. Different from existing relevance models, we capture and represent multi-field and local&global semantic features of a Query-POI pair to measure the semantic similarity. Besides, we observe a hidden correlation between origin-destination locations in ride-hailing scenarios, and propose two location embeddings to characterize the specific correlation. By incorporating the geographic correlation with the semantic similarity, our model achieves better performance in POI ranking. Experimental results on two real-world click-through datasets demonstrate the improvements of our model over state-of-the-art methods.
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Li, Chengming, Li Liu, Zhaoxin Dai, and Xiaoli Liu. "Different Sourcing Point of Interest Matching Method Considering Multiple Constraints." ISPRS International Journal of Geo-Information 9, no. 4 (March 31, 2020): 214. http://dx.doi.org/10.3390/ijgi9040214.
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Point of interest (POI) matching is critical but is the most technically difficult part of multi-source POI fusion. The accurate matching of POIs from different sources is important for the effective reuse of POI data. However, the existing research on POI matching usually adopts weak constraints, which leads to a low POI matching accuracy. To address the shortcomings of previous studies, this paper proposes a POI matching method with multiple determination constraints. First, according to various attributes (name, class, and spatial location), a new calculation model considering spatial topology, name role labeling, and bottom-up class constraints is established. In addition, the optimal threshold values corresponding to the different attribute constraints are determined. Second, according to the multiattribute constraint values and optimal thresholds, a constraint model with multiple strict determination constraints is proposed. Finally, actual POI data from Baidu Map and Gaode Map in Dongying city is used to validate the method. Comparing to the existing method, the accuracy and recall of the proposed method increase 0.3% and 7.1%, respectively. The experimental results demonstrate that the proposed POI matching method attains a high matching accuracy and high feasibility.
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Zhou, Chaoran, Hang Yang, Jianping Zhao, and Xin Zhang. "POI Classification Method Based on Feature Extension and Deep Learning." Journal of Advanced Computational Intelligence and Intelligent Informatics 24, no. 7 (December 20, 2020): 944–52. http://dx.doi.org/10.20965/jaciii.2020.p0944.
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The automatic classification of point of interest (POI) function types based on POI name texts and intelligent computing can provide convenience in travel recommendations, map information queries, urban function divisions, and other services. However, POI name texts belong to short texts, which few characters and sparse features. Therefore, it is difficult to guarantee the feature learning ability and classification effect of the model when distinguishing the POI function types. This paper proposes a POI classification method based on feature extension and deep learning to establish a short-text classification model. We utilize an Internet search engine as an external knowledge base to introduce real-time, large-scale text feature information to the original POI text to solve the limitation of sparse POI name text features. The input text information is represented by the attention calculation matrix used to reduce the noise information of the extended text and the word-embedding matrix of the original text. We utilize a convolutional neural network with excellent local feature extraction ability to establish the classification model. Experimental results on a real-world dataset (obtained from Baidu) show the excellent performance of our model in POI classification tasks compared with other baseline models.
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Chen, Mengchi, Haotian Jiang, and Chunping Zhang. "Selected Genetic Factors Associated with Primary Ovarian Insufficiency." International Journal of Molecular Sciences 24, no. 5 (February 23, 2023): 4423. http://dx.doi.org/10.3390/ijms24054423.
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Primary ovarian insufficiency (POI) is a heterogeneous disease resulting from non-functional ovaries in women before the age of 40. It is characterized by primary amenorrhea or secondary amenorrhea. As regards its etiology, although many POI cases are idiopathic, menopausal age is a heritable trait and genetic factors play an important role in all POI cases with known causes, accounting for approximately 20% to 25% of cases. This paper reviews the selected genetic causes implicated in POI and examines their pathogenic mechanisms to show the crucial role of genetic effects on POI. The genetic factors that can be found in POI cases include chromosomal abnormalities (e.g., X chromosomal aneuploidies, structural X chromosomal abnormalities, X-autosome translocations, and autosomal variations), single gene mutations (e.g., newborn ovary homeobox gene (NOBOX), folliculogenesis specific bHLH transcription factor (FIGLA), follicle-stimulating hormone receptor (FSHR), forkhead box L2 (FOXL2), bone morphogenetic protein 15 (BMP15), etc., as well as defects in mitochondrial functions and non-coding RNAs (small ncRNAs and long ncRNAs). These findings are beneficial for doctors to diagnose idiopathic POI cases and predict the risk of POI in women.
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Wang, Xican, Yanheng Liu, Xu Zhou, Xueying Wang, and Zhaoqi Leng. "A Point-of-Interest Recommendation Method Exploiting Sequential, Category and Geographical Influence." ISPRS International Journal of Geo-Information 11, no. 2 (January 20, 2022): 80. http://dx.doi.org/10.3390/ijgi11020080.
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Point of interest (POI) recommendation as an important service in location-based social networks has developed rapidly, which can help users find more interesting unknown locations and facilitate service providers to provide users with more accurate notifications or advertisements. Some existing work has addressed the data sparsity problem of collaborative filtering by incorporating contextual information into the model. However, they ignore the sequence relationship contained in the user’s historical check-in records, which makes it difficult to accurately model the user’s preference and affects the final recommendation results. To acquire users’ preference for a location more accurately, this paper proposes a new POI recommendation framework exploiting sequential, category, and geographical influence. Firstly, we obtain the latent vector of POI and the latent vector of the user’s preference for POI from the user’s check-in sequence based on the word embedding model. Next, a virtual common access sequence for users is constructed according to the user’s check-ins, a new similarity computation method is present combining category differentiation and POI latent vector. Then, we apply it to the collaborative filtering framework to get the user’s behavioral preference probability of POI. In addition, the kernel density estimation method is employed to get the user’s geographical preference probability of POI by considering the geographical influence. Finally, the POI recommendation list is obtained by the weighted fusion of the two users’ preference probability to improve the performance of the POI recommendation. Experimental results on two datasets indicate that the proposed method has better performance in terms of three evaluation metrics than the other five POI recommendation methods.
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Lersten, Ivy, Elizabeth Clain, and Nanette Santoro. "Use of Hormone Therapy in Women with Early Menopause and Premature Ovarian Insufficiency." Seminars in Reproductive Medicine 38, no. 04/05 (September 2020): 302–8. http://dx.doi.org/10.1055/s-0040-1721719.
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AbstractWomen with early menopause or primary ovarian insufficiency (POI) experience a menopausal state a decade or more earlier than their peers. The health consequences for POI are vast and varied with detrimental effects seen on neurological, psychological, bone, and cardiovascular systems. The risk profile of POI patients requires special attention, as they differ from a typical menopausal population. This review will explore the health risks associated with POI and examine the various treatment options and also the risks associated with hormone therapy. Given the risks and benefits, POI patients should be strongly encouraged to start hormone therapy until the median age of menopause.
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Attisani, Antonio. "Poetica d’ora in poi." Mimesis Journal, no. 7, 2 (December 1, 2018): 177–80. http://dx.doi.org/10.4000/mimesis.1587.
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Carmen, Raff. "?Prima mangiare, poi filosofare?" Journal of International Development 12, no. 7 (2000): 1019–30. http://dx.doi.org/10.1002/1099-1328(200010)12:7<1019::aid-jid697>3.0.co;2-e.
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Zhou, Chaoran, Jianping Zhao, Xin Zhang, and Chenghao Ren. "Entity Alignment Method of Points of Interest for Internet Location-Based Services." Journal of Advanced Computational Intelligence and Intelligent Informatics 24, no. 7 (December 20, 2020): 837–45. http://dx.doi.org/10.20965/jaciii.2020.p0837.
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In Internet applications, the description for the same point of interest (POI) entity for different location-based services (LBSs) is not completely identical. The POI entity information in a single LBS data source contains incomplete data and exhibits insufficient objectivity. Aligning and consolidating POI entities from various LBSs can provide users with more comprehensive, objective, and authoritative POI information. We herein propose a multi-attribute measurement-based entity alignment method for Internet LBSs to achieve POI entity alignment and data consolidation. This method is based on multi-attribute information (geographical information, text coincidence information, semantic information) of POI entities and is combined with different measurement methods to calculate the similarity of candidate entity pairs. Considering the demand for computational efficiency, the particle swarm optimization algorithm is used to train the model and optimize the weights of multi-attribute measurements. A consolidation strategy is designed for the LBS text data and user rating data from different sources to obtain more comprehensive and objective information. The experimental results show that, compared with other baseline models, the POI alignment method based on multi-attribute measurement performed the best. Using this method, the information of POI entities in multisource LBS can be integrated to serve netizens.
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Shi, Yanan, Xiao Xu, Ting Liu, Rongyun Wang, Jingming Xu, Yujing Wu, Bin Ding, and Qiuhua Sun. "Shenhuang Plaster Application Improves Gastrointestinal Motility in Mice with Postoperative Ileus through Intestinal Microbiota." Evidence-Based Complementary and Alternative Medicine 2022 (August 8, 2022): 1–13. http://dx.doi.org/10.1155/2022/2823315.
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Postoperative ileus (POI) is a common surgical complication, and its incidence remains high. Shenhuang Plaster (SHP) is a famous traditional Chinese medicine with a definite curative effect on postoperative intestinal dysfunction; however, the mechanisms involved in these effects are unclear. Accordingly, in this study, we constructed a POI mouse model and used the intestinal flora as the target to explore the regulatory effect of SHP on gastrointestinal motility. The results illustrated that SHP applied at the Shenque acupoint promoted the recovery of gastrointestinal motility, relieved intestinal villus atrophy and basal damage caused by POI, protected the integrity of intestinal tissue morphology, and alleviated the inflammatory response in the intestinal tissue of POI model mice. In addition, we clarified the role of the intestinal flora in the occurrence and development of POI, further evaluated the changes in the intestinal flora in each group of mice, and analysed the regulatory effect of SHP on the intestinal flora in mice with POI. The results suggested that SHP might improve gastrointestinal motility disorder in POI mice by effectively regulating intestinal flora.
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Huang, Jianfeng, Yuefeng Liu, Yue Chen, and Chen Jia. "Context-Aware POI Sequence Recommendation with Attention-Based Neural Network." Abstracts of the ICA 1 (July 15, 2019): 1–2. http://dx.doi.org/10.5194/ica-abs-1-126-2019.
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<p><strong>Abstract.</strong> Location-based social networks (LBSNs) is playing an increasingly important role in our daily life, through which users can share their locations and location-related contents at any time. The Location information implicitly expresses user's behaviour preference. Therefore, LBSNs is being widely explored for Point-of-Interest (POI) recommendation in recent years. Most of existing POI recommenders only recommend a single POI, while sometimes successive POI sequence recommendation is more practical. For example, when we travel to a strange city, what we expect is not a single POI recommendation, but a POI sequence recommendation which contains a set of POIs and the order of visiting them. To solve this problem, this paper proposes a novel model called Context-Aware POI Sequence Recommendation (CPSR), which is developed based on an attention-based neural network. Neural network has made a great success in various of field because of its powerful learning ability. Recently, dozens of works has demonstrated that attention mechanism can make the neural network models more reasonable.</p>
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Ling, Li, Jiying Hou, Yan Wang, Han Shu, and Yubin Huang. "Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency." Cell Transplantation 31 (January 2022): 096368972211291. http://dx.doi.org/10.1177/09636897221129171.
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Premature ovarian insufficiency (POI) can cause multiple sequelae and is currently incurable. Mesenchymal stem cell (MSC) transplantation might provide an effective treatment method for POI. However, the clinical application of systemic MSC transplantation is limited by the low efficiency of cell homing to target tissue in vivo, including systemic MSC transplantation for POI treatment. Thus, exploration of methods to promote MSC homing is necessary. This study was to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on the migration and homing of transplanted human amnion–derived MSCs (hAD-MSCs) to ovaries in rats with chemotherapy-induced POI. For LIPUS treatment, hAD-MSCs were exposed to LIPUS or sham irradiation. Chemokine receptor expressions in hAD-MSCs were detected by polymerase chain reaction (PCR), Western blot, and immunofluorescence assays. hAD-MSC migration was detected by wound healing and transwell migration assays. Cyclophosphamide-induced POI rat models were established to evaluate the effects of LIPUS on the homing of systemically transplanted hAD-MSCs to chemotherapy-induced POI ovaries in vivo. We found that hAD-MSCs expressed chemokine receptors. The LIPUS promoted the expression of chemokine receptors, especially CXCR4, in hAD-MSCs. SDF-1 induced hAD-MSC migration. The LIPUS promoted hAD-MSC migration induced by SDF-1 through SDF-1/CXCR4 axis. SDF-1 levels significantly increased in ovaries induced by chemotherapy in POI rats. Pretreating hAD-MSCs with LIPUS increased the number of hAD-MSCs homing to ovaries in rats with chemotherapy-induced POI to some extent. However, the difference was not significant. Both hAD-MSC and LIPUS-pretreated hAD-MSC transplantation reduced ovarian injuries and improved ovarian function in rats with chemotherapy-induced POI. CXCR4 antagonist significantly reduced the number of hAD-MSCs- and LIPUS-pretreated hAD-MSCs homing to POI ovaries, and further reduced their efficacy in POI treatment. According to these findings, pretreating MSCs with LIPUS before transplantation might provide a novel, convenient, and safe technique to explore for improving the homing of systemically transplanted MSCs to target tissue.
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Zhang, Hang, Mingxin Gan, and Xi Sun. "Incorporating Memory-Based Preferences and Point-of-Interest Stickiness into Recommendations in Location-Based Social Networks." ISPRS International Journal of Geo-Information 10, no. 1 (January 15, 2021): 36. http://dx.doi.org/10.3390/ijgi10010036.
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In location-based social networks (LBSNs), point-of-interest (POI) recommendations facilitate access to information for people by recommending attractive locations they have not previously visited. Check-in data and various contextual factors are widely taken into consideration to obtain people’s preferences regarding POIs in existing POI recommendation methods. In psychological effect-based POI recommendations, the memory-based attenuation of people’s preferences with respect to POIs, e.g., the fact that more attention is paid to POIs that were checked in to recently than those visited earlier, is emphasized. However, the memory effect only reflects the changes in an individual’s check-in trajectory and cannot discover the important POIs that dominate their mobility patterns, which are related to the repeat-visit frequency of an individual at a POI. To solve this problem, in this paper, we developed a novel POI recommendation framework using people’s memory-based preferences and POI stickiness, named U-CF-Memory-Stickiness. First, we used the memory-based preference-attenuation mechanism to emphasize personal psychological effects and memory-based preference evolution in human mobility patterns. Second, we took the visiting frequency of POIs into consideration and introduced the concept of POI stickiness to identify the important POIs that reflect the stable interests of an individual with respect to their mobility behavior decisions. Lastly, we incorporated the influence of both memory-based preferences and POI stickiness into a user-based collaborative filtering framework to improve the performance of POI recommendations. The results of the experiments we conducted on a real LBSN dataset demonstrated that our method outperformed other methods.
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Chen, Chunpeng James, and Zhiwu Zhang. "GRID: A Python Package for Field Plot Phenotyping Using Aerial Images." Remote Sensing 12, no. 11 (May 26, 2020): 1697. http://dx.doi.org/10.3390/rs12111697.
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Aerial imagery has the potential to advance high-throughput phenotyping for agricultural field experiments. This potential is currently limited by the difficulties of identifying pixels of interest (POI) and performing plot segmentation due to the required intensive manual operations. We developed a Python package, GRID (GReenfield Image Decoder), to overcome this limitation. With pixel-wise K-means cluster analysis, users can specify the number of clusters and choose the clusters representing POI. The plot grid patterns are automatically recognized by the POI distribution. The local optima of POI are initialized as the plot centers, which can also be manually modified for deletion, addition, or relocation. The segmentation of POI around the plot centers is initialized by automated, intelligent agents to define plot boundaries. A plot intelligent agent negotiates with neighboring agents based on plot size and POI distributions. The negotiation can be refined by weighting more on either plot size or POI density. All adjustments are operated in a graphical user interface with real-time previews of outcomes so that users can refine segmentation results based on their knowledge of the fields. The final results are saved in text and image files. The text files include plot rows and columns, plot size, and total plot POI. The image files include displays of clusters, POI, and segmented plots. With GRID, users are completely liberated from the labor-intensive task of manually drawing plot lines or polygons. The supervised automation with GRID is expected to enhance the efficiency of agricultural field experiments.
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Saari, Viivi, Elina Holopainen, Outi Mäkitie, and Saila Laakso. "Pubertal development and premature ovarian insufficiency in patients with APECED." European Journal of Endocrinology 183, no. 5 (November 2020): 513–20. http://dx.doi.org/10.1530/eje-20-0516.
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Objective: To determine the natural course of pubertal development, growth during puberty, and development of POI in females with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also called autoimmune polyendocrine syndrome type I. Design: Longitudinal follow-up study. Methods: A national cohort of females with APECED aged ≥12 years were followed during 1965–2018. Attainment of adult height was defined when patients’ height increased less than 1 cm per year. Diagnosis of POI was based on delayed puberty or POI symptoms with amenorrhea, and/or FSH ≥40 IU/L. Results: Altogether 40 women with APECED were followed up to the average age of 37.3 (range: 14.6–61.9) years; 16 females (40%) were ≥ 40 years. Pubertal development started spontaneously in 34 patients and 29 had spontaneous menarche. POI developed in 28 patients (70%) at the median age of 16.0 years (range: 11.3–36.5), and in 20 of them (71%) before attaining adult height. In 11 cases puberty was induced or completed by hormonal therapy. Patients with POI were significantly shorter at menarche, but adult heights did not differ from non-POI females. Patients with POI had more often primary adrenocortical insufficiency (93% vs 58%, P = 0.017) and ovarian antibodies (81% vs 30%, P=0.003) compared to those with normal ovarian function (n = 12). Conclusions: POI developed in the majority of patients with APECED, often before or shortly after menarche. Timely commencement of hormonal replacement therapy is important to ensure optimal pubertal development and growth. The possibility of fertility preservation before development of POI in APECED patients should be further studied.
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Rudiansyah, Rudiansyah. "Makna Puak Poi pada Upacara Paisin dalam Budaya Masyarakat Tionghoa di Kota Medan." Metahumaniora 7, no. 2 (September 3, 2017): 17. http://dx.doi.org/10.24198/metahumaniora.v7i2.18825.
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ABSTRAK. Tujuan penelitian ini untuk mengetahui makna puak poi dalam upacara paisin dalam budaya masyarakat Tionghoa di Kota Medan. Penelitian ini menggunakan metode kualitatif yang ditulis secara deskriptif. Metode pengumpulan data dilakukan melalui studi lapangan berupa: wawancara, observasi, perekaman upacara penggunaan puak poi, pengamatan terlibat (participant observer), dan studi kepustakaan. Secara kontekstual puak poi merupakan sarana komunikasi kepada Tuhan, dewa, atau leluhur di alam baka. Secara semiotik puak poi memiliki tiga petanda jawaban, yaitu: sengpoi (jawaban “ya”),jipoi (jawaban yang menggantung “antara ya dan tidak”), dan kampoi (jawaban “tidak”). Teks pertanyaan sekaligus permintaan umumnya menggunakan bahasa Indonesia, dengan tema berupa rezeki, jodoh, pengobatan, karir kerja, dan pembersihan altar keluarga.Kata kunci: Tionghoa, Medan, puak poi, paisin, sengpoi, jipoi, kampoi
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., Rudiansyah. "Makna Puak Poi pada Upacara Paisin dalam Budaya Masyarakat Tionghoa di Kota Medan." Metahumaniora 7, no. 2 (September 3, 2017): 17. http://dx.doi.org/10.24198/mh.v7i2.18825.
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ABSTRAK. Tujuan penelitian ini untuk mengetahui makna puak poi dalam upacara paisin dalam budaya masyarakat Tionghoa di Kota Medan. Penelitian ini menggunakan metode kualitatif yang ditulis secara deskriptif. Metode pengumpulan data dilakukan melalui studi lapangan berupa: wawancara, observasi, perekaman upacara penggunaan puak poi, pengamatan terlibat (participant observer), dan studi kepustakaan. Secara kontekstual puak poi merupakan sarana komunikasi kepada Tuhan, dewa, atau leluhur di alam baka. Secara semiotik puak poi memiliki tiga petanda jawaban, yaitu: sengpoi (jawaban “ya”),jipoi (jawaban yang menggantung “antara ya dan tidak”), dan kampoi (jawaban “tidak”). Teks pertanyaan sekaligus permintaan umumnya menggunakan bahasa Indonesia, dengan tema berupa rezeki, jodoh, pengobatan, karir kerja, dan pembersihan altar keluarga.Kata kunci: Tionghoa, Medan, puak poi, paisin, sengpoi, jipoi, kampoi
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Setyawan, Setyawan, and Junaidi Pangeran Saputra. "Kajian Penambahan Konsentrat Ampas Tahu Terhadap Pertambahan Berat Badan Sapi Peranakan Ongole." Jurnal Pengembangan Penyuluhan Pertanian 18, no. 34 (December 31, 2021): 166. http://dx.doi.org/10.36626/jppp.v18i34.704.
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ABSTRAKTernak sapi potong Peranakan Ongole (PO) memiliki keunggulan sebagai sapi tropis; tahan panas, tahan gangguan parasit dan toleransi terhadap pakan yang mengandung serat kasar tinggi. Kajian ini bertujuan untuk melihat penambahan konsentrat ampas tahu terhadap PBB ternak sapi potong PO. Metode menggunakan ternak sapi PO betina berjumlah 4 ekor, umur sapi PO1 dan PO2 berumur ≥ 2 tahun, sapi PO3 dan PO4 berumur ≤ 2 tahun. Pemberian ampas tahu sebanyak 1% dan hijauan 10% dari berat badan, penentuan jumlah pakan yang diberikan berdasarkan berat badan awal ternak sapi PO yaitu: PO1 berat badan awal 428 kg, ampas tahu 4,3 kg, hijauan 43 kg, PO2 berat bawal 297 kg, ampas tahu 3,0 kg, hijauan 30 kg, PO3 berat badan awal 203 kg, ampas tahu 2,0 kg, hijauan 20 kg, PO4 berat badan awal 142 kg, ampas tahu 1,4 kg, hijauan 14 kg. Peubah yang diukur adalah PBBH ternak sapi PO selama tiga bulan. Analisis data menggunakan analisis deskriptif. Hasil kajian bahwa ternak sapi PO yang diberikan hijauan dan konsentrat ampas tahu memiliki rata-rata PBBH 0,55 kg/ekor/hari. Ternak sapi PO2 memiliki rata-rata PBBH paling tinggi (0,70 kg/ekor/hari) dan terendah ternak sapi PO4 (0,28 kg/ekor/hari). Rata-rata PBB selama tiga bulan pada sapi PO1: 27,7 kg/ekor/bulan, PO2: 44,7 kg/ekor/bulan, PO3: 37,7 kg/ekor/bulan, PO4: 13,2 kg/ekor/bulan. Rata-rata PBB sapi PO keseluruhan selama 3 bulan yaitu 30,7 kg. Kesimpulan bahwa rata-rata PBBH ternak sapi PO adalah 0,55 kg dan rata-rata PBB seluruh ternak sapi PO per tiga bulan yaitu 30,7 kg.Kata kunci: Ampas Tahu, Pertambahan Berat Badan, Sapi Peranakan OngoleABSTRACTOngole Peranakan (PO) beef cattle have advantages as tropical cattle; heat resistance, parasitic disturbance resistance, and tolerance to feeds containing high crude fiber. This study aims to see the addition of tofu pulp concentrate to PBB of PO beef cattle. The method uses 4 female PO cattle, PO1 and PO2 cattle aged 2 years, PO3 and PO4 cows 2 years old. Giving tofu dregs as much as 1% and forage 10% of body weight, determining the amount of feed given based on the initial body weight of PO cattle, namely: PO1 initial body weight 428 kg, tofu dregs 4,3 kg, forage 43 kg, PO2 pomfret weight 297 kg, tofu dregs 3,0 kg, forage 30 kg, PO3 initial weight 203 kg, tofu dregs 2,0 kg, forage 20 kg, PO4 initial weight 142 kg, tofu dregs 1,4 kg, forage 14 kg. The variable measured was the PBBH of PO cattle for three months. Data analysis used descriptive analysis. The results of the study showed that PO cattle that were given forage and tofu waste concentrate had an average PBBH of 0,55 kg/head/day. PO2 cattle had the highest average PBBH (0,70 kg/head/day) and the lowest were PO4 cattle (0,28 kg/head/day). Average PBB for three months in cattle PO1: 27,7 kg/head/month, PO2: 44,7 kg/head/month, PO3: 37,7 kg/head/month, PO4: 13,2 kg/head /month. The average PBB of PO cattle for 3 months is 30,7 kg. The conclusion is that the average PBBH of PO cattle is 0,55 kg and the average PBBH of all PO cattle per three months is 30,7 kg.Keywords: Ongole Breeding Cattle, Tofu Residue, Weight Gain
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Yuan, Guangchao, Munindar P. Singh, and Pradeep K. Murukannaiah. "An interpretable framework for investigating the neighborhood effect in POI recommendation." PLOS ONE 16, no. 8 (August 5, 2021): e0255685. http://dx.doi.org/10.1371/journal.pone.0255685.
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Geographical characteristics have been proven to be effective in improving the quality of point-of-interest (POI) recommendation. However, existing works on POI recommendation focus on cost (time or money) of travel for a user. An important geographical aspect that has not been studied adequately is the neighborhood effect, which captures a user’s POI visiting behavior based on the user’s preference not only to a POI, but also to the POI’s neighborhood. To provide an interpretable framework to fully study the neighborhood effect, first, we develop different sets of insightful features, representing different aspects of neighborhood effect. We employ a Yelp data set to evaluate how different aspects of the neighborhood effect affect a user’s POI visiting behavior. Second, we propose a deep learning–based recommendation framework that exploits the neighborhood effect. Experimental results show that our approach is more effective than two state-of-the-art matrix factorization–based POI recommendation techniques.
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Huang, Qiuyan, Bo Liu, Rufang Jiang, Shengbin Liao, Zhiyao Wei, Yin Bi, Xueyuan Liu, et al. "G-CSF-mobilized peripheral blood mononuclear cells combined with platelet-rich plasma accelerate restoration of ovarian function in cyclophosphamide-induced POI rats†." Biology of Reproduction 101, no. 1 (April 29, 2019): 91–101. http://dx.doi.org/10.1093/biolre/ioz077.
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Abstract Peripheral blood mononuclear cells (PBMCs) are rich in hematopoietic cells and mesenchymal stem cells. Platelet-rich plasma (PRP) is rich in various growth factors. PBMCs and PRP have been suggested, individually, to restore ovarian function by improving the local microenvironment. The current study investigated the effect of granulocyte colony-stimulating factor (G-CSF)-mobilized PBMCs combined with PRP on restoring ovarian function in rats with primary ovarian insufficiency (POI). Thirty adult female rats were randomly subdivided into five groups: normal control (control), cyclophosphamide (CTX) plus subsequent PBS (POI + PBS), CTX plus subsequent PRP (POI + PRP), CTX plus subsequent G-CSF-mobilized PBMCs (POI + PBMCs), and CTX plus subsequent G-CSF-mobilized PBMCs combined with PRP (POI + PBMCs + PRP). CTX exposure induced the typical POI phenotype with increased diestrus; shortened estrus; follicle arrest at all stages; decreased serum levels of estradiol-17β (E2) and anti-Mullerian hormone (AMH); and increased levels of follicle-stimulating hormone (FSH). Transplantation of mobilized PBMCs with PRP resulted in a much earlier restoration of the estrous cycle, sex hormone levels, and preantral follicle growth in POI rats. Expression of the male-specific Sry gene in the ovarian tissues of POI + PBMCs + PRP female recipient rats was evident at 5, 10, and 20 days posttransplantation along with significant increases in the expression of angiogenesis markers CD34+ and VEGF and folliculogenesis markers AMH and FSHR. Additionally, PBMCs in combination with PRP mitigated granulosa cell apoptosis by downregulating BAX and upregulating BCL-2. These results demonstrate that G-CSF-mobilized PBMCs combined with PRP accelerate the restoration of ovarian function in POI rats by increasing ovarian neovascularization, reducing granulosa cell apoptosis, and promoting folliculogenesis.
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Gifford, Connor, Amy J. Minnema, Justin Baum, Michelle L. Humeidan, Daniel E. Vazquez, and H. Francis Farhadi. "Development of a postoperative ileus risk assessment scale: identification of intraoperative opioid exposure as a significant predictor after spinal surgery." Journal of Neurosurgery: Spine 31, no. 5 (November 2019): 748–55. http://dx.doi.org/10.3171/2019.5.spine19365.
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OBJECTIVEPostoperative ileus (POI) is associated with abdominal pain, nausea, vomiting, and delayed mobilization that in turn lead to diminished patient satisfaction, increased hospital length of stay (LOS), and increased healthcare costs. In this study, the authors developed a risk assessment scale to predict the likelihood of developing POI following spinal surgery.METHODSThe authors undertook a retrospective review of a prospectively maintained registry of consecutive patients who underwent arthrodesis/fusion surgeries between May 2013 and December 2017. They extracted clinical information, including cumulative intraoperative and postoperative opioid doses using standardized converted morphine milligram equivalent (MME) values. Univariate and multivariate analyses were performed and several categorical and continuous variables were evaluated in a binary logistic regression model built with backward elimination to assess for independent predictors. A points-based prediction model was developed and validated to determine the risk of POI.RESULTSA total of 334 patients who underwent spinal fusion surgeries were included. Fifty-six patients (16.8%) developed POI, more frequently in those who underwent long-segment surgeries compared to short-segment surgeries (33.3% vs 10.4%; p < 0.001). POI was associated with an increased LOS when compared with patients who did not develop POI (8.0 ± 4.5 days vs 4.4 ± 2.4 days; p < 0.01). The incidences of liver disease (16% vs 3.7%; p = 0.01) and substance abuse history (12.0% vs 3.2%; p = 0.04) were higher in POI patients than non-POI patients undergoing short-segment surgeries. While the incidences of preoperative opioid intake (p = 0.23) and cumulative 24-hour (87.7 MME vs 73.2 MME; p = 0.08) and 72-hour (225.6 MME vs 221.4 MME; p = 0.87) postoperative opioid administration were not different, remifentanil (3059.3 µg vs 1821.5 µg; p < 0.01) and overall intraoperative opioid (326.7 MME vs 201.7 MME; p < 0.01) dosing were increased in the POI group. The authors derived a multivariate model based on the 5 most significant factors predictive of POI (number of surgical levels, intraoperative MME, liver disease, age, and history of substance abuse) and calculated relative POI risks using a derived 32-point system.CONCLUSIONSIntraoperative opioid administration, incorporated in a comprehensive risk assessment scale, represents an early and potentially modifiable predictor of POI. These data indicate that potential preventive strategies, implemented as part of enhanced recovery after surgery protocols, could be instituted in the preoperative phase of care to reduce POI incidence.
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Szeliga, Anna, Anna Calik-Ksepka, Marzena Maciejewska-Jeske, Monika Grymowicz, Katarzyna Smolarczyk, Anna Kostrzak, Roman Smolarczyk, Ewa Rudnicka, and Blazej Meczekalski. "Autoimmune Diseases in Patients with Premature Ovarian Insufficiency—Our Current State of Knowledge." International Journal of Molecular Sciences 22, no. 5 (March 5, 2021): 2594. http://dx.doi.org/10.3390/ijms22052594.
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Premature ovarian insufficiency (POI), previously known as premature ovarian failure or premature menopause, is defined as loss of ovarian function before the age of 40 years. The risk of POI before the age of 40 is 1%. Clinical symptoms develop as a result of estrogen deficiency and may include amenorrhea, oligomenorrhea, vasomotor instability (hot flushes, night sweats), sleep disturbances, vulvovaginal atrophy, altered urinary frequency, dyspareunia, low libido, and lack of energy. Most causes of POI remain undefined, however, it is estimated that anywhere from 4–30% of cases are autoimmune in origin. As the ovaries are a common target for autoimmune attacks, an autoimmune etiology of POI should always be considered, especially in the presence of anti-oocyte antibodies (AOAs), autoimmune diseases, or lymphocytic oophoritis in biopsy. POI can occur in isolation, but is often associated with other autoimmune conditions. Concordant thyroid disorders such as hypothyroidism, Hashimoto thyroiditis, and Grave’s disease are most commonly seen. Adrenal autoimmune disorders are the second most common disorders associated with POI. Among women with diabetes mellitus, POI develops in roughly 2.5%. Additionally, autoimmune-related POI can also present as part of autoimmune polyglandular syndrome (APS), a condition in which autoimmune activity causes specific endocrine organ damage. In its most common presentation (type-3), APS is associated with Hashomoto’s type thyroid antibodies and has a prevalence of 10–40%. 21OH-Antibodies in Addison’s disease (AD) can develop in association to APS-2.
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Wijaya, Roby, Honni Honni, and Hendry Pratama. "AUDIT SISTEM INFORMASI PADA PT WALEPAY FINANSIAL TEKNOLOGI MENGGUNAKAN KERANGKA KERJA COBIT 4.1 DAN BALANCED SCORECARD." JBASE - Journal of Business and Audit Information Systems 3, no. 1 (March 30, 2020). http://dx.doi.org/10.30813/jbase.v3i1.2058.
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PT Walepay Finansial Teknologi adalah sebuah perusahaan dibidang teknologi finansial (tekfin). Pada perusahaan ini penulis ingin mengetahui seberapa baik penerapan tata kelola yang sudah dijalankan oleh PT Walepay Finansial Teknologi. Dengan menggunakan kerangka kerja COBIT 4.1 dan BSC Model. Penulis akan mengukur tingkat kematangan pada bagian penerapan pengaturan dan perencanaannya. Penulis menggunakan 10 domain yaitu PO1, PO2, P03, PO4, PO5, PO6, PO7, PO8, PO9 dan PO10. Untuk BSC modelnya, penulis menggunakan perspektif internal perusahaan. Untuk tingkat kematangan didapat pada domain PO1 dan PO6 dengan nilai 3, sedangkan terendah terdapat pada domain PO7 dengan nilai 1,5. Rekomendasi untuk domain PO adalah mematangkan lagi rencana penerapan TI pada perusahaan, terutama dalam menetapkan hubungan proses TI dengan organisasi, memaksimalkan investasi TI yang ada, serta lebih memperhatikan lagi resiko resiko yang ada dari kehadiran TI. Berdasarkan hasil yang didapatkan penulis, penulis memberikan saran kepada perusahaan untuk memperhitungkan resiko TI pada masa mendatang agar perencanaan perusahaan kedepannya lebih baik. Penulis juga menggunakan Balanced Scorecard untuk melihat perspektif dari proses bisnis internal dan perspektif pembelajaran, dan pertumbuhan. Dari perspektif proses bisnis internal, perusahaan sudah cukup baik dalam menjalankan proses bisnis, sedangkan dari perspektif pembelajaran dan pertumbuhan, perusahaan juga sudah cukup baik. Rata-rata dari hasil kesepuluh domain PO adalah 2,25 yaitu dalam tahap Repeatable but Intuitive.
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Rhutso, Yopovinu, Lopa M. Kakoti, Jagannath D. Sharma, and Manoj Kalita. "Significance of Pattern of Invasion in Tongue Squamous Cell Carcinoma—A Retrospective Study from a Regional Cancer Center of North-East India." South Asian Journal of Cancer, February 2, 2022. http://dx.doi.org/10.1055/s-0041-1736201.
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Introduction Many multiparametric models and scoring systems had been proposed in oral tongue squamous cell carcinoma (OTSCC) to predict the survival and recurrence, out of which pattern of invasion (POI) is gaining focus recently. Objective We conducted a retrospective study with the aim to see the prognostic significance of the POI and other parameters such as depth of invasion, perineural invasion (PNI), and lymph node status in OTSCC. Materials and Methods The slides of already diagnosed OTSCC cases were prepared from January 2015 to December 2017 records and studied by two pathologists for different patterns using Brandwein-Gensler scoring system. The different clinicopathologic parameters were compared with different POI. Statistical analysis was performed to present cumulative survival outcomes and for comparison. Results Most of our patients were > 40 years of age with male preponderance. Tumor differentiation pattern was assessed using Broders' system of grading that showed 85% of tumors were well, 12.5% tumors were moderately differentiated, and 2.5% tumors were poorly differentiated. The worst POI was predominantly pattern III (50%) followed by pattern II (32.5%) and pattern IV (13.8%). Most patients were in stage II (33.8%) followed by stage III (32.5%), stage IV (26.3%), and stage I (7.5%). There was an inverse relationship between POI with tumor stage and recurrence. A strong statistically significant association was found between POI with perineural infiltration and lymph node metastasis. Conclusion We concluded from our study that worst POI is significantly associated with number of lymph nodes metastasis and perineural infiltration and hence can be used as an independent prognostic factor.
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Cerruti, Massimo. "Alcuni usi di poi e poi dopo nell’interazione verbale." XXIV, 2023/1 (gennaio-marzo), no. 24 (February 13, 2023). http://dx.doi.org/10.35948/2532-9006/2023.27917.
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Rehnitz, Julia, and Thomas Strowitzki. "Prämature Ovarialinsuffizienz (POI)." Der Gynäkologe, May 5, 2021. http://dx.doi.org/10.1007/s00129-021-04802-8.
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"Sassi. E poi?" CADMO, no. 1 (August 2017): 44. http://dx.doi.org/10.3280/cad2017-001005.
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Silvén, H., S. M. Savukoski, P. Pesonen, E. Pukkala, M. Gissler, E. Suvanto, and M. Niinimäki. "Incidence and familial risk of premature ovarian insufficiency in the Finnish female population." Human Reproduction, February 4, 2022. http://dx.doi.org/10.1093/humrep/deac014.
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Abstract STUDY QUESTION What is the incidence of premature ovarian insufficiency (POI), has the incidence of POI changed over time, and what is the risk of POI among relatives of POI women? SUMMARY ANSWER The incidence of POI increased among females aged 15–19 years from 2007 onwards and decreased in older age groups, and among relatives of women with POI the risk of POI is significantly increased. WHAT IS KNOWN ALREADY So far, there has been no good quality, nationwide studies of the incidence of POI. Early menopause has been associated with the elevated risk of early menopause among relatives, but the knowledge of the familial risk of POI is scarce. Lower socioeconomic status has been associated with lower age at natural menopause. STUDY DESIGN, SIZE, DURATION Population-based study with 5011 women diagnosed with POI in 1988–2017. The data were collected from national registries and covers POI subjects in entire Finland. PARTICIPANTS/MATERIALS, SETTING, METHODS Women with hormone replacement therapy reimbursement for POI were identified from Social Insurance Institution (SII). We calculated POI incidence in different age groups and studied the changes in the incidence rate over time in 5-year segments. Four population-based controls were selected from the Digital and Population Data Services Agency (DVV) for each POI woman. Family members of the POI cases and controls were identified from the DVV and linked to SII reimbursement data to identify POI diagnoses among them. The familial risk of POI was estimated with a logistical regression model. MAIN RESULTS AND THE ROLE OF CHANCE The incidence was highest in the 35–39 age group, ranging from 73.8/100 000 women-years in 1993–1997 to 39.9/100 000 women-years in 2013–2017. From 2007, the incidence among 15- to 19-year-olds rose from 7.0 to 10.0/100 000 women-years in 2015–2017. Cumulative incidence of POI for women under 40 years in 1988–2017 was 478/100 000 women. The relative risk of POI among relatives of women with POI was 4.6 (95% CI 3.3–6.5) compared to relatives of women without POI. POI women tended to have slightly lower socioeconomic status and level of education compared to controls. LIMITATIONS, REASONS FOR CAUTION For some women with POI, diagnosis or reimbursement may be lacking. However, we presume that these women represent a minority due to the nature of the disease and the economic benefits of reimbursement. Some changes in the incidence of POI can reflect changes in clinical practice and changing treatments and reimbursement criteria. WIDER IMPLICATIONS OF THE FINDINGS The risk of developing POI is significantly higher in women who have first-degree relatives diagnosed with POI. Raising awareness of the increased risk might lead to earlier diagnosis and initiation of hormonal replacement therapy, possibly preventing adverse effects of low oestrogen levels, such as osteoporosis. STUDY FUNDING/COMPETING INTEREST(S) This work was financially supported by the Oulu University Hospital. H.S. received a grant from Finnish Menopause Society. S.M.S. received a grant from the Finnish Menopause Society, the Finnish Medical Foundation and the Juho Vainio Foundation. The authors do not have any competing interests to declare. TRIAL REGISTRATION NUMBER N/A.
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Ohba, Tetsuro, Kensuke Koyama, Hiroki Oba, Kotaro Oda, Nobuki Tanaka, and Hirotaka Haro. "Clinical Importance, Incidence and Risk Factors for the Development of Postoperative Ileus Following Adult Spinal Deformity Surgery." Global Spine Journal, December 17, 2020, 219256822097656. http://dx.doi.org/10.1177/2192568220976562.
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Study Design: Retrospective observational study of a cohort of consecutive patients. Objectives: Postoperative ileus (POI) is associated with a variety of adverse effects. Although the incidence of and risk factors for POI following spinal surgery have been reported, the frequency and pathology of POI after spinal corrective surgery for adult spinal deformity (ASD) are still largely unknown. The study objectives were to: (1) clarify the prevalence and clinical significance of POI, (2) elucidate the risk factors for POI, (3) determine radiographically which preoperative and/or postoperative spinal parameters predominantly influence the risk of POI after spinal corrective surgery for ASD. Methods: We included data from 144 consecutive patients who underwent spinal corrective surgery. Perioperative medical complications and clinical information were extracted from patient electronic medical records. Preoperative radiographic parameters and changes in radiographic parameters after surgery were compared between patients with and without POI. Multivariate logistic regression analyses were performed to clarify potential risk factors for POI. Results: POI developed in 25/144 (17.4%) patients and was the most common complication in the present study. The frequencies of smoking, gastroesophageal reflux disease, and lateral lumbar interbody fusion (LLIF), as well as the duration of surgery were significantly greater in the group with POI versus the group without POI. Among radiographic parameters, only the change in thoracolumbar kyphosis (TLK) from before to after surgery was significantly larger in the group with POI. Multivariate logistic regression analysis showed that male sex, LLIF and large changes in TLK from before to after surgery were significantly associated with the development of POI. Conclusions: These results suggested that LLIF and large corrections in TLK were independent risk factors for POI after ASD surgery. When patients with ASD have large TLK preoperatively, and it is determined that a large correction is needed, physicians must be aware of the potential for occurrence of POI.
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Forbes, Connor M., Ali Cyrus Chehroudi, Miles Mannas, Andrea Bisaillon, Tracey Hong, Alan So, Kelly Mayson, and Peter C. Black. "Defining postoperative ileus and associated risk factors in patients undergoing radical cystectomy with an Enhanced Recovery After Surgery (ERAS) program." Canadian Urological Association Journal 15, no. 2 (July 27, 2020). http://dx.doi.org/10.5489/cuaj.6546.
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Introduction: Postoperative ileus (POI) is a common complication of radical cystectomy (RC), occurring in 1.6–23.5% of cases. It is defined heterogeneously in the literature. POI increases hospital length of stay and postoperative morbidity. Factors such as age, epidural use, length of procedure, and blood loss may impact POI. In this study, we aimed to evaluate risk factors that contribute to POI in a cohort of patients managed with a comprehensive Enhanced Recovery After Surgery (ERAS) protocol.
Methods: A retrospective review of consecutive patients who underwent RC from March 2015 to December 2016 at Vancouver General Hospital was performed. POI was defined a priori as insertion of nasogastric tube for nausea or vomiting, or failure to advance to a solid diet by the seventh postoperative day. To illustrate heterogeneity in previous studies, we also evaluated POI using other previously reported definitions in the RC literature. The influence of potential risk factors for POI, including patient comorbidities, American Society of Anesthesiologists score, gender, age, prior abdominal surgery or radiation, length of operation, diversion type, extent of lymph node dissection, removal date of analgesic catheter, blood loss, and fluid administration volume was analyzed.
Results: Thirty-six (27%) of 136 patients developed POI. Using other previously reported definitions for POI, the incidence ranged from <1–51%. Node positive status and age at surgery were associated with POI on univariate analysis but not multivariable analysis.
Conclusions: A large range of POI incidence was observed using previously published definitions of POI. We advocate for a standardized definition of POI when evaluating RC outcomes. POI occurs frequently even with a comprehensive ERAS protocol, suggesting that additional measures are needed to reduce the rate of POI.
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Zhao, Shenglin, Tong Zhao, Haiqin Yang, Michael Lyu, and Irwin King. "STELLAR: Spatial-Temporal Latent Ranking for Successive Point-of-Interest Recommendation." Proceedings of the AAAI Conference on Artificial Intelligence 30, no. 1 (February 21, 2016). http://dx.doi.org/10.1609/aaai.v30i1.9986.
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Successive point-of-interest (POI) recommendation in location-based social networks (LBSNs) becomes a significant task since it helps users to navigate a number of candidate POIs and provides the best POI recommendations based on users’ most recent check-in knowledge. However, all existing methods for successive POI recommendation only focus on modeling the correlation between POIs based on users’ check-in sequences, but ignore an important fact that successive POI recommendation is a time-subtle recommendation task. In fact, even with the same previous check-in information, users would prefer different successive POIs at different time. To capture the impact of time on successive POI recommendation, in this paper, we propose a spatial-temporal latent ranking (STELLAR) method to explicitly model the interactions among user, POI, and time. In particular, the proposed STELLAR model is built upon a ranking-based pairwise tensor factorization framework with a fine-grained modeling of user-POI, POI-time, and POI-POI interactions for successive POI recommendation. Moreover, we propose a new interval-aware weight utility function to differentiate successive check-ins’ correlations, which breaks the time interval constraint in prior work. Evaluations on two real-world datasets demonstrate that the STELLAR model outperforms state-of-the-art successive POI recommendation model about 20% in Precision@5 and Recall@5.
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Samad, Navira, Hanh H. Nguyen, Hikaru Hashimura, Julie Pasco, Mark Kotowicz, Boyd J. Strauss, Peter R. Ebeling, Frances Milat, and Amanda J. Vincent. "Abnormal Trabecular Bone Score, Lower Bone Mineral Density and Lean Mass in Young Women With Premature Ovarian Insufficiency Are Prevented by Oestrogen Replacement." Frontiers in Endocrinology 13 (May 19, 2022). http://dx.doi.org/10.3389/fendo.2022.860853.
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BackgroundLow bone density (BMD) and fractures commonly affect women with premature ovarian insufficiency (POI). However, bone microarchitecture and body composition data are lacking.ObjectiveTo assess and characterise musculoskeletal phenotype and effects of oestrogen replacement therapy (ERT) in women with POI.MethodCross-sectional and longitudinal studies of 60 normal karyotype women with POI, aged 20-40 years, from 2005-2018. Dual x-ray absorptiometry (DXA)-derived spinal (LS) and femoral neck (FN) BMD, trabecular bone score (TBS), appendicular lean mass (ALM), total fat mass (TFM), and fracture prevalence were compared with 60 age-, and BMI-matched population-based controls. Longitudinal changes in bone and body composition variables and ERT effects were analysed using linear mixed models over a median duration of 6 years.ResultsWomen with POI were subdivided into spontaneous (s)-POI (n=25) and iatrogenic (i)-POI (n=35). Median(range) age of POI diagnosis was 34 (10-40) years with baseline DXA performed at median 1(0-13) year post-diagnosis. ERT was used by 82% women (similar for both POI groups). FN-BMD were lowest in s-POI (p<0.002). Low TBS was more common in s-POI [(44%), p=0.03], versus other groups. LS-BMD and ALM were lower in both s-POI and i-POI groups than controls (p<0.05). Fracture prevalence was not significantly different: 20% (s-POI), 17% (i-POI), and 8% (controls) (p=0.26). Longitudinal analysis of 23 POI women showed regular ERT was associated with ALM increment of 127.05 g/year (p<0.001) and protected against bone loss. However, ERT interruption was associated with annual reductions in FN BMD and TBS of 0.020g/cm2 and 0.0070 (p<0.05), respectively.ConclusionDeficits in BMD, trabecular microarchitecture, and lean mass were present in women with POI. However, regular ERT protected against declines in bone variables, with an increase in ALM. Assessment of skeletal and muscle health, and advocating ERT adherence, is essential in POI to optimise musculoskeletal outcomes.