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Journal articles on the topic 'POEMS syndrom'

Author: Grafiati

Published: 8 February 2025

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1

Schwarz, Ricarda, and Marius Horger. "POEMS-Syndrom." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 190, no. 02 (January 18, 2018): 106–10. http://dx.doi.org/10.1055/s-0043-121581.

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2

Braun, S. A., P. Albrecht, A. Methner, and S. Hanneken. "POEMS-Syndrom." Der Hautarzt 62, no. 10 (September 15, 2011): 722–25. http://dx.doi.org/10.1007/s00105-011-2239-1.

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3

Cohnen, Mathias, Michael Uppenkamp, Peter Meusers, and Günter Brittinger. "POEMS-Syndrom." Medizinische Klinik 93, no. 11 (November 1998): 678–82. http://dx.doi.org/10.1007/bf03044880.

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4

Erbslöh-Möller, Brigitte, Boris Perras, and Klaus Sack. "POEMS-Syndrom mit Niereninsuffizienz." Medizinische Klinik 94, no. 3 (March 1999): 159–64. http://dx.doi.org/10.1007/bf03044846.

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5

Ebhardt, H., T. Eidner, A. Berndt, D. Katenkamp, and H. Kosmehl. "Das POEMS-Syndrom - Ein Fallbericht." Der Pathologe 21, no. 3 (May 29, 2000): 255–59. http://dx.doi.org/10.1007/s002920050397.

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6

Mäurer, M., and C. Sommer. "POEMS-Syndrom - ungewöhnliche Manifestation mit beidseitigem Charcot-Gelenk." DMW - Deutsche Medizinische Wochenschrift 124, no. 12 (March 25, 2008): 346–50. http://dx.doi.org/10.1055/s-2007-1024305.

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7

Schaumberg, J., C. Müller-Habich, and A. Müller-Jensen. "POEMS-Syndrom – schwierig zu diagnostizieren – schwierig zu therapieren." Aktuelle Neurologie 37, no. 02 (March 2010): 86–88. http://dx.doi.org/10.1055/s-0029-1223517.

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8

Birkenbach, A., F. Kühlhorn, M. Grube, H. Helbig, and M. A. Gamulescu. "POEMS-Syndrom als seltene Ursache eines bilateralen Papillenödems." Der Ophthalmologe 114, no. 3 (June 30, 2016): 262–65. http://dx.doi.org/10.1007/s00347-016-0287-8.

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9

Kurzen, Kunz, and Nigg. "Blauverfärbung der Hände, Taubheitsgefühl an den Füssen, indolente Lymphknotenschwellung zervikal bei einem 73-jährigen Mann." Praxis 95, no. 41 (October 1, 2006): 1589–93. http://dx.doi.org/10.1024/1661-8157.95.41.1589.

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Ein 73-jähriger Patient wurde uns zugewiesen wegen einer Blauverfärbung der Hände. Zusätzlich bestanden anamnestisch und klinisch eine B-Symptomatik, brennende Schmerzen mit Taubheitsgefühl an den Füssen bei Polyneuropathie sowie eine indolente Lymphknotenschwellung zervikal. 1996 und 2001 waren wegen einer lokalisierten angiofollikulären Lympknotenhyperplasie (Castleman-Erkrankung) bereits Halslymphknoten exzidiert worden. Laborchemisch bestanden erhöhte Entzündungszeichen, eine Hypothyreose und eine monoklonale Gammopathie. Die Bildgebung zeigte generalisierte Lymphknotenvergrösserungen zervikal, mediastinal und abdominal sowie eine Splenomegalie. Somit bestand das Vollbild eines POEMS-Syndroms (Sonderform des Multiplen Myeloms) mit Polyneuropathie, Organomegalie (Milz), Endokrinopathie (Schilddrüse), monoklonaler Gammopathie und Skin Changes (Blauverfärbung der Hände). Die generalisierte Lymphadenopathie entsprach histologisch einem Rezidiv der vorbestehenden Castleman-Erkrankung, deren Assoziation mit dem POEMS-Syndrom bekannt ist. Der Patient sprach gut auf die eingeleitete Steroidtherapie an und ist heute weitgehend beschwerdefrei.

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10

Barry, Jean-Cyriaque, Marc Gleichmann, and Helmut Wilhelm. "Beidseitige Papillenschwellung bei Polyneuropathie, Organomegalies Endokrinopathie, monoklonalen Proteinen und Hautveränderungen (POEMS-Syndrom)." Klinische Monatsblätter für Augenheilkunde 215, no. 07 (July 1999): 59–63. http://dx.doi.org/10.1055/s-2008-1034671.

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11

Ulas, Sevtap Tugce, and Süha Dasdelen. "Multizentrische Castleman-Erkrankung in Kombination mit Polyserositis und POEMS-Syndrom – Fallbericht und Übersichtsbeitrag." Der Internist 62, no. 7 (June 17, 2021): 777–85. http://dx.doi.org/10.1007/s00108-021-01063-4.

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12

Dowker, A., B. Hermelin, and L. Pring. "A savant poet." Psychological Medicine 26, no. 5 (September 1996): 913–24. http://dx.doi.org/10.1017/s003329170003525x.

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SynopsisPoems by an individual with a diagnosis of Asperger's Syndrome were analysed and compared with those of a comparison poet. Though the savant poet performed less efficiently on formal language tests supposed to tap creativity, there were few differences between the two poets in regard to the poems' content and the use of various structural devices. The poems by the savant referred more often to aspects of self-analysis, while descriptions of people not related to the self were less frequent. Both poets made use of similes and metaphors. The results are discussed in terms of different modular domains within the language system.

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13

Gutiérrez Araujo, Vianca, Esther Hernández Santos, and Luis Camacho Saavedra. "Síndrome de POEMS: a propósito de un caso." Horizonte Médico (Lima) 22, no. 3 (September 27, 2022): e1561. http://dx.doi.org/10.24265/horizmed.2022.v22n3.10.

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14

Wang, Yang, Yalong Liu, Xiaoli Huang, Lan Peng, and Zhijun Zhang. "POEMS syndrome characterized by bone lesions: A case report." Medicine 102, no. 50 (December 15, 2023): e36678. http://dx.doi.org/10.1097/md.0000000000036678.

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Rationale: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal paraproteinemia, and skin changes) syndrome is a rare clinical syndrome characterized by multiple peripheral neuropathies, hepatosplenomegaly, endocrine disorders, monoclonal paraproteinemia, and dermatosis. The main manifestations of POMES were nerve and skin changes, and bone disease was not reported. Here, we report a case of POEMS syndrome with the main manifestation of bone lesions. Patient concerns: POMES is rare and its clinical manifestations are complex, making it difficult for patients to find the department they should visit. It is easy to miss diagnosis and misdiagnosis, delay the treatment time of patients, and affect the prognosis. Diagnosis interventions: The patient was admitted to the gastroenterology department due to hepatic insufficiency. Multiple osteogenic changes were found by improved enhanced CT due to screening for causes of hepatic insufficiency, and spleen enlargement was indicated by abdominal ultrasound. Due to the involvement of multiple system problems, and follow-up of medical history, it was found that there was a history of discoloration of the distal limb in cold weather in the past 5 years. All things considered, it may be POMES. Further refinement of the bone marrow examination revealed active proliferation of granulocytes and erythrocytes. Bone marrow biopsy showed active hyperplasia, dominated by granulocytes. IFE showed IgA (type λ) and monoclonal myeloma (M) protein bands. To sum up, POMES diagnosis is considered. Outcomes: After the diagnosis is clear and the informed consent of the patient and his family is obtained, prednisone acetate is anti-inflammatory, lenalidomide is used to regulate immune function, liver and stomach protection treatment and bile secretion promotion are given. The patient reported improvement in liver function, significant improvement in overall and limb stiffness, and was discharged with improvement. Lessons: Although bone lesions are not typically the main manifestation of POEMS syndrome, this diagnosis should be considered when this manifestation is combined with organ enlargement, skin changes, and peripheral neuropathy. In addition, the collection of medical history is crucial, when there is a clinical manifestation and auxiliary examination does not match, the idea should be expanded according to the relevant evidence, and finally make the corresponding diagnosis.

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15

Vaithy, Anandraj, Shanmugasamy K, Bhavani Bhavani, and Koteeswaran G. "Spectrum of Clinico-Pathological Profile of Poems Syndrome." Annals of Pathology and Laboratory Medicine 5, no. 6 (June 2018): A527–532. http://dx.doi.org/10.21276/apalm.1986.

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16

Kyle, Robert A. "POEMS Syndrome." Clinical Lymphoma 4, no. 3 (December 2003): 186. http://dx.doi.org/10.3816/clm.2003.n.030.

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17

Keddie, Stephen, and Michael P. Lunn. "POEMS syndrome." Current Opinion in Neurology 31, no. 5 (October 2018): 551–58. http://dx.doi.org/10.1097/wco.0000000000000610.

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18

Scarlato, Marina, and Stefano C. Previtali. "POEMS syndrome." Current Opinion in Neurology 24, no. 5 (October 2011): 491–96. http://dx.doi.org/10.1097/wco.0b013e328348e107.

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19

Kumar, Naresh, Deepak Rosha, Puneet Gupta, and Tarun Sharma. "POEMS Syndrome." Apollo Medicine 3, no. 3 (September 2006): 318–21. http://dx.doi.org/10.1016/s0976-0016(11)60219-6.

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20

Soubrier, Martin. "Syndrome POEMS." La Presse Médicale 36, no. 11 (November 2007): 1676–82. http://dx.doi.org/10.1016/j.lpm.2007.06.009.

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21

Marcant, P., L. Terriou, E. Boyle, P. Y. Hatron, and D. Staumont-Sallé. "Syndrome POEMS." Annales de Dermatologie et de Vénéréologie 146, no. 1 (January 2019): 82–85. http://dx.doi.org/10.1016/j.annder.2018.11.003.

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22

Leung, Nancy W. Y., Joseph C. K. Pang, and Christopher W. K. Lam. "Poems syndrome." Pathology 23, no. 2 (1991): 167–71. http://dx.doi.org/10.3109/00313029109060819.

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23

Dispenzieri, Angela. "POEMS Syndrome." Hematology 2005, no. 1 (January 1, 2005): 360–67. http://dx.doi.org/10.1182/asheducation-2005.1.360.

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Abstract POEMS syndrome is defined by the presence of a peripheral neuropathy (P), a monoclonal plasma cell disorder (M), and other paraneoplastic features, the most common of which include organomegaly (O), endocrinopathy (E), skin changes (S), papilledema, edema, effusions, ascites, and thrombocytosis. Virtually all patients will have either sclerotic bone lesion(s) or co-existent Castleman’s disease. Not all features of the disease are required to make the diagnosis, and early recognition is important to reduce morbidity. Other names for the syndrome include osteosclerotic myeloma, Crow-Fukase syndrome, or Takatsuki syndrome. Because the peripheral neuropathy is frequently the overriding symptom and because the characteristics of the neuropathy are similar to that chronic inflammatory demyelinating polyneuropathy (CIDP), patients are frequently misdiagnosed with CIDP or monoclonal gammopathy of underdetermined significance (MGUS)-associated peripheral neuropathy. Not until additional features of the POEMS syndrome are recognized is the correct diagnosis made and effective therapies initiated. Clues to an early diagnosis include thrombocytosis and sclerotic bone lesions on plain skeletal radiographs. Therapies that may be effective in patients with CIDP and MGUS-associated peripheral neuropathy (intravenous gammaglobulin and plasmapheresis) are not effective in patients with POEMS. Instead, the mainstays of therapy for patients with POEMS include irradiation, corticosteroids, and alkylator-based therapy, including high-dose chemotherapy with peripheral blood stem cell transplantation.

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24

Laurenti, L., and S. De Matteis. "POEMS syndrome." Drugs of the Future 33, no. 6 (2008): 543. http://dx.doi.org/10.1358/dof.2008.033.06.1209527.

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25

Caswell, R., T. Warner, A. Mehta, and L. Ginsberg. "POEMS syndrome." Practical Neurology 6, no. 2 (April 1, 2006): 111–16. http://dx.doi.org/10.1136/jnnp.2006.089003.

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26

Dispenzieri, Angela. "POEMS syndrome." Blood Reviews 21, no. 6 (November 2007): 285–99. http://dx.doi.org/10.1016/j.blre.2007.07.004.

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27

Perniciaro, Charles. "POEMS syndrome." Seminars in Dermatology 14, no. 2 (June 1995): 162–65. http://dx.doi.org/10.1016/s1085-5629(05)80013-6.

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28

Dispenzieri, Angela, Taxiarchis Kourelis, and Francis Buadi. "POEMS Syndrome." Hematology/Oncology Clinics of North America 32, no. 1 (February 2018): 119–39. http://dx.doi.org/10.1016/j.hoc.2017.09.010.

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29

Jaccard, Arnaud. "POEMS Syndrome." Hematology/Oncology Clinics of North America 32, no. 1 (February 2018): 141–51. http://dx.doi.org/10.1016/j.hoc.2017.09.011.

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30

Arkhipov, I. E., I. Yu Vergunova, N. A. Malkova, and D. S. Korobko. "POEMS-syndrome." Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123, no. 7 (2023): 15. http://dx.doi.org/10.17116/jnevro202312307215.

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31

Kumar, Naresh, Deepak Rosha, Puneet Gupta, and Tarun Sharma. "Poems Syndrome." Apollo Medicine 3, no. 3 (September 2006): 318–21. http://dx.doi.org/10.1177/0976001620060312.

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32

Paolo Sotelo, Pedro, Fanny Elizabeth Ramírez Calderón, and María Del Pilar Quiñones Avila. "SÍNDROME POEMS ASOCIADO A ENFERMEDAD DE CASTLEMAN. UN REPORTE DE CASO." Revista de la Facultad de Medicina Humana 19, no. 4 (October 15, 2019): 120–25. http://dx.doi.org/10.25176/rfmh.v19i4.2145.

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33

Wysocka-Dubielecka, Kalina, Andrzej Bizoń, Katarzyna Głogowska, Dorota Mączyńska-Karcz, Katarzyna Łoza, Kazimierz Kalbarczyk, Oskar Janeczek, and Marek Braszkiewicz. "Pseudoscleroderma associated with POEMS syndrome." Dermatology Review 106, no. 5 (2019): 529–37. http://dx.doi.org/10.5114/dr.2019.90001.

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34

Valencia, Juan, Alais Cruz, Jess FuentesLara, Edgar MuozMiramontes, Alejandro SolrzanoMelndez, Adrian VallesQuintanilla, Jorge Lpez, Luis BayardoLo, and pez pez. "Fractionated Stereotactic radiotherapy for POEMS syndrome, a case report." International Journal of Medical Reviews and Case Reports 2, Reports in Surgery and Dermatolo (2019): 1. http://dx.doi.org/10.5455/ijmrcr.poems-syndrome-fractionated-stereotactic-radiotherapy.

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35

Del Río, R., M. Alsina, J. Monteagudo, D. Torremorell, U. González, J. Luelmo, and J. M. Mascaró. "POEMS syndrome and multiple angioproliferative lesions mimicking generalized histiocytomas." Acta Dermato-Venereologica 74, no. 5 (September 1, 1994): 388–90. http://dx.doi.org/10.2340/0001555574388390.

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A case of POEMS syndrome and Castleman's multicentric disease is reported. Multiple long-standing cutaneous lesions, histologically similar to histiocytomas, were the initial manifestation of POEMS syndrome. A high incidence of angiomatous lesions associated with POEMS syndrome has already been established. To our knowledge, this report is the first report to associate multiple angioproliferative lesions mimicking generalized histiocytomas with POEMS syndrome.

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36

Rose, C., M. Mahieu, E. Hachulla, T. Façon, PY Hatron, F. Bauters, and B. Devulder. "Le POEMS syndrome." La Revue de Médecine Interne 18, no. 7 (July 1997): 553–62. http://dx.doi.org/10.1016/s0248-8663(97)80807-7.

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37

Ding, Chao, and Yanqiu Li. "A case of paraprotein-negative POEMS syndrome: Case report and literature review." Medicine 103, no. 36 (September 6, 2024): e39267. http://dx.doi.org/10.1097/md.0000000000039267.

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Rationale: POEMS syndrome is a rare monoclonal plasma cell disease. The diagnosis of POEMS requires polyradiculoneuropathy and monoclonal plasma proliferating as 2 mandatory criteria, at least 1 of the major criteria (Castleman disease, elevated vascular endothelial growth factor level, and sclerotic bone lesion), and at least 1 of the minor criteria (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, and thrombocytosis/polycythemia). This multisystem disorder is of high heterogeneity, and few variants of POEMS with no evidence of monoclonal gammopathy have been described, which further complicates the diagnosis in clinical practice. Now, we report a case of paraprotein-negative POEMS syndrome. Patients concerns: A 45-year-old woman complained of lower extremity edema, shortness of breath, abdominal distension, and lymphadenopathy for few years. Finally, she was diagnosed with paraprotein-negative POEMS syndrome. With the lenalidomide-based regimen, the symptoms were all relieved. Diagnosis: Paraprotein-negative POEMS syndrome. Intervention: Lenalidomide-based regimen and some supportive therapy. Outcome: All symptoms were relieved after 1 year of treatment. Lessons: Physicians should pay more attention to the POEMS syndrome, especially the POEMS syndrome variants, which are absence of paraprotein; probably, these variants are just “on the way” to classic POEMS syndrome antiplasma cell therapy, which remains the treatment of choice.

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38

Dörner, Marc, Mihai Ceanga, Frank Schreiber, Jan-Hendrik Stahl, Cornelius Kronlage, Julia Wittlinger, Magdalena Kramer, et al. "High-Resolution Nerve Ultrasound Abnormalities in POEMS Syndrome—A Comparative Study." Diagnostics 11, no. 2 (February 9, 2021): 264. http://dx.doi.org/10.3390/diagnostics11020264.

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Background: High-resolution nerve ultrasound (HRUS) has been proven to be a valuable tool in the diagnosis of immune-mediated neuropathies, such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) is an important differential diagnosis of CIDP. Until now, there have been no studies that could identify specific HRUS abnormalities in POEMS syndrome patients. Thus, the aim of this study was to assess possible changes and compare findings with CIDP patients. Methods: We retrospectively analyzed HRUS findings in three POEMS syndrome and ten CIDP patients by evaluating cross-sectional nerve area (CSA), echogenicity and additionally calculating ultrasound pattern scores (UPSA, UPSB, UPSC and UPSS) and homogeneity scores (HS). Results: CIDP patients showed greater CSA enlargement and higher UPSS (median 14 vs. 11), UPSA (median 11.5 vs. 8) and HS (median 5 vs. 3) compared with POEMS syndrome patients. However, every POEMS syndrome patient illustrated enlarged nerves exceeding reference values, which were not restricted to entrapment sites. In CIDP and POEMS syndrome, heterogeneous enlargement patterns could be identified, such as inhomogeneous, homogeneous and regional nerve enlargement. HRUS in CIDP patients visualized both increased and decreased echointensity, while POEMS syndrome patients pictured hypoechoic nerves with hyperechoic intraneural connective tissue. Discussion: This is the first study to demonstrate HRUS abnormalities in POEMS syndrome outside of common entrapment sites. Although nerve enlargement was more prominent in CIDP, POEMS syndrome patients revealed distinct echogenicity patterns, which might aid in its differentiation from CIDP. Future studies should consider HRUS and its possible role in determining diagnosis, prognosis and treatment response in POEMS syndrome.

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39

Ueda, Shuji, Sayoko Yonemoto, Kazumasa Oka, Naohiko Fujii, Keiichi Nakata, Hitomi Matsunaga, Seiko Kataoka, et al. "Lenalidomide and Dexamethasone for a Patient of POEMS Syndrome Presenting with Massive Ascites." Case Reports in Hematology 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/818946.

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POEMS syndrome is a multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. POEMS syndrome is a rare cause of refractory ascites. We report the case of a patient with POEMS syndrome presenting with massive ascites who was treated with very-low-dose lenalidomide and dexamethasone. A 57-year-old Japanese man was admitted to our hospital with pleural effusion, massive ascites, and leg edema. The diagnosis of POEMS syndrome was made based on the combination of the following findings: peripheral neuropathy, organomegaly, endocrinopathy, serum monoclonal protein elevation, skin changes, plasma VEGF elevation, and evidence of extravascular volume overload. Renal dysfunction induced by biopsy-proven renal involvement of POEMS syndrome was observed. Massive ascites of the patient dramatically diminished with long-time treatment of very-low-dose lenalidomide and dexamethasone. Lenalidomide seems to be a very promising therapy for POEMS syndrome presenting with extravascular volume overload such as edema, pleural effusion, and ascites. Very-low-dose lenalidomide might be effective especially for the patients with POEMS-related nephropathy.

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Bhattacharjee, S., I. Siyad, and BV Maramattom. "Chronic diarrhea - The poetic masquerade." Journal of Postgraduate Medicine 68, no. 4 (2022): 239–42. http://dx.doi.org/10.4103/jpgm.jpgm_1169_21.

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Chronic diarrhea, by definition, is the passage of loose/liquid stools, with increased frequency (more than three times/day), or an output of over 200 g/day, lasting for a duration of four or more weeks. The clinical approach to identify the cause of chronic diarrhea generally depends on the local socioeconomic status. In high-income countries, systemic causes such as irritable bowel syndrome (IBS), inflammatory bowel disease, malabsorption syndromes (lactose intolerance/coeliac disease) are primarily considered. In mid- to low-income countries, infective causes like chronic bacterial, mycobacterial, fungal infections, HIV, bowel cancer are considered before systemic causes/malabsorption syndromes. Amyloidosis, more accurately, reactive amyloidosis is one of the rarer causes of chronic/persistent diarrhea. Inflammatory colitis secondary to POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) as a cause for chronic diarrhea has been reported only in a handful of cases and is often missed. We present such a case of chronic diarrhea in a middle-aged man, who was eventually diagnosed to have POEMS syndrome.

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41

Korotaeva, V. V., Ya B. Kushnir, O. V. Kudyasheva, A. Yu Polushin, and V. S. Krasnov. "POEMS-syndrome with the disease onset in the form of сhronic dysimmune neuropathy." Russian Medical Inquiry 6, no. 10 (2022): 589–95. http://dx.doi.org/10.32364/2587-6821-2022-6-10-589-595.

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POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) is a rare paraneoplastic disease associated with plasma cell dyscrasias, the pathogenesis of which is currently not fully understood. The diagnosis of POEMS syndrome is commonly confirmed after an extended period of time from the disease onset, since the syndrome is rare and can be mistaken for other neurological diseases, for instance, chronic inflammatory demyelinating polyneuropathy (CIDP). The article describes a clinical case of the disease in a young male patient with the onset of neurological disorders in the form of the CIDP clinical phenotype, refractory to first-line therapy, and further systemic clinical and laboratory comorbidities of POEMS syndrome. The necessary laboratory and radiological studies were performed to confirm the diagnosis. The diagnosis was established based on the presence of 2 major, 1 additional major and 4 minor criteria of POEMS syndrome in the patient. Then the patient was discharged for further observation of hematologists to initiate basic therapy of POEMS syndrome. Early detection of the POEMS syndrome "red flags" in patients with the CIDP allows for timely treatment initiation, prevention of further disease progression and the development of persistent disabling disorders. KEYWORDS: POEMS-syndrome, chronic inflammatory demyelinating polyneuropathy, paraprotein, monoclonal gammopathy of undetermined significance. FOR CITATION: Korotaeva V.V., Kushnir Ya.B., Kudyasheva O.V. et al. POEMS-syndrome with the disease onset in the form of сhronic dysimmune neuropathy. Russian Medical Inquiry. 2022;6(10):589–595 (in Russ.). DOI: 10.32364/2587-6821-2022-6-10-589-595.

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42

Shi, Huan, Xiaohong Jiang, Long Wang, and Jiayan Zhou. "Missed diagnosis of POEMS syndrome with onset of progressive fatigue and numbness: a case report." Journal of International Medical Research 49, no. 2 (February 2021): 030006052098670. http://dx.doi.org/10.1177/0300060520986706.

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POEMS syndrome is a rare multisystem disease associated with an underlying plasma cell disorder. Its name is an acronym for peripheral neuropathy (P), endocrinopathy (E), organomegaly (O), monoclonal plasma cell proliferative disorder (M), and skin changes (S). This case report describes a patient with POEMS syndrome who presented with progressive fatigue and numbness in the lower extremities. Initially, the patient was erroneously diagnosed with diabetes and diabetic peripheral neuropathy because of the endocrinopathy associated with POEMS syndrome. After a second hospitalization, the patient was diagnosed with POEMS syndrome and recovered with alkylator therapy and a peripheral blood stem cell transplant. The patient’s overall condition was improved at the 1-year follow-up. POEMS syndrome should be considered if a patient presents with endocrinopathy and unexplained peripheral neuropathy.

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43

Liang, Minrui, Zhixing Jiang, Zhiguang Lin, Bobin Chen, Hejian Zou, Weiguo Wan, and Jun Liu. "Polyneuropathy as Novel Initial Manifestation in a Case of “Nonsecretory” POEMS Syndrome with Sjögren’s Syndrome." Case Reports in Medicine 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/1276759.

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POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome driven by plasma cell dyscrasias. We report a patient with novel initial manifestation of polyneuropathy, which was considered due to Sjögren’s syndrome but with poor response to methylprednisolone (120 mg/d) and intravenous immunoglobulin (IVIg). Further investigation by imaging tests and following biopsy eventually confirmed the diagnosis of POEMS syndrome secondary to solitary plasmocytoma. To our knowledge, this is the first reported case of POEMS syndrome with Sjögren’s syndrome occurring in the absence of a peripheral monoclonal gammopathy, highlighting the diagnostic challenges posed by this disease and reviewing the diagnostic role of (18) F-FDG PET/CT in POEMS syndrome.

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Rathore, Hemant, and Nirav Thaker. "Chronic Inflammatory Demyelinating Polyradiculoneuropathy as a Presentation of Plasmacytoma." Indian Journal of Nuclear Medicine 38, no. 4 (2023): 379–80. http://dx.doi.org/10.4103/ijnm.ijnm_44_23.

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Polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes (POEMS) syndrome is one of the rare paraneoplastic disorders of the multiorgan association whose initialism describes the principal clinical features as polyneuropathy, organomegaly, endocrinopathy, M-protein elevation, and skin changes caused by an underlying plasma cell disorder, one of the major diagnostic criteria for which is the presence of an osseous lesion. We present a case of POEMS syndrome with nearly all signs and symptoms on clinical and hematological examinations, which was further investigated with MRI of the whole spine and 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan, as the latter is a very useful imaging modality for evaluation of any paraneoplastic syndromes, including myeloproliferative disorders such as plasmacytoma or multiple myeloma, and lymphoproliferative or other malignancies.

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Du, Hua Ping, Ye Zhang, Lei Min Sun, and Liang Luo. "Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review." Journal of International Medical Research 49, no. 4 (April 2021): 030006052199096. http://dx.doi.org/10.1177/0300060521990967.

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POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome is rare, with polyneuropathy and monoclonal plasma cell disorder generally considered as essential diagnostic symptoms. We report two cases of POEMS syndrome without monoclonal protein expression. The first case was a 72-year-old man who had experienced recurrent edema of the lower limbs for 2 years and abdominal distention for 2 months. The other case was a 62-year-old man with a 5-year history of recurrent numbness of the extremities and muscle weakness, which had become serious over the preceding 3 months. Both patients had various symptoms that matched those of POEMS syndrome, but neither had monoclonal protein expression. However, a diagnosis of POEMS syndrome was made in each case. Both patients were treated with lenalidomide and dexamethasone, after which their symptoms improved and laboratory test results normalized. The findings in these two cases suggest the possibility that POEMS syndrome may occur without monoclonal protein expression. The diagnostic criteria of POEMS syndrome may thus need further investigation.

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Bykov, Yu N., T. B. Bender, Yu N. Vasiliev, A. S. Bokhna, A. V. Shirokova, S. V. Vasilkova, and N. I. Merinova. "CLINICAL OBSERVATION OF POEMS SYNDROME: DIFFICULTIES IN DIAGNOSIS AND TREATMENT." Baikal Medical Journal 1, no. 1 (2022): 57–63. http://dx.doi.org/10.57256/2949-0715-2022-1-57-63.

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POEMS syndrome is a rare systemic disease that manifests with the following main symptoms: polyneuropathy, organomegaly, endocrinopathy, paraproteinemia, skin changes. A clinical case of POEMS syndrome in a 42-year-old patient is presented. The diagnosis was verified after the appearance and increase of extraneural symptoms, such as severe edema, respiratory failure, endocrinopathy, hepatosplenomegaly, lymphadenopathy. Additional examinations of the patient revealed paraproteinemia which is typical for this disease. The patient had a course of specific therapy in the hematology department that caused a positive effect. Due to multisystem organ damage, there may be a variety of onsets of the disease, which makes correct diagnosis and prescription of appropriate therapy difficult.

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Casacov, Rolando, Oscar Díaz Moyano, and Mercedes Cassino. "Sindrome de Poems." Revista de la Facultad de Ciencias Médicas de Córdoba 56, no. 2 (November 30, 2023): 113–21. http://dx.doi.org/10.31053/1853.0605.v56.n2.40331.

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Poems syndrome :s a rare multisistemic disorder. It manifestations are Polynueropathy, Organomegaly, Endocrinopathy,and / 01Edema. Monoclonal protein and changes in the Skin. (P.O.E.M.S.)Though some bibliography make no difference with osteoesclerotic mieloma it is considered a real syndrome.The polynueropathy is customarily severe. Although high levels of inrnullo- globulins has been found in the poems, it has not been isolatcd a specific antibody that explain the polynueropathy even though it is strongly suspected.The organomegaly, endocrinopathy, changes in the skin and other systems and involved organs could be in relationship toproducts secreted by plasmatic celis. Wc review the physiopathology and bibliography of the Poems, especially its neurological expression its nosologic location different from osteosclerotic myeloma and a possible relationship to the Herpes Virus S.It was crossed in Medline the terms P.O.E.M.S. and syndrome and were obtained 271 abstracts that were all examined and finallyselected the bibliography considerate meaningful for the objectives. It is presented briefly a case.P.O.E.M.S. is a syndrome that is associated to multiple plasma eclI dyscracia, included the osteoesclerotic myeloma.Prognosis and the treatment vary with the underlying diseasc. As physiopathology of this syndrome is insinuated the action of the interleukines 1- (IL-1 beta) and 6 (IL-6), the vascular growth endothelial factor (VGEF), the tunioral necrosis factor alpha (TNF-alpha) and antibodies anti- nerve. The P.O.E.M.S. is a syndrome with own Palabras claves: Síndrome de POEMS aso- identity. ciado con mieloma múltiple.The Herpes Virus 8 may plays a key rol Material y Métodos to uncover the Poems physiopathology.

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Bourgeault, Emilie, Alice Dahl, Marie-Marthe Thibeault, Audrey Dupéré, Anne-Marie Drolet, and Jean Mathieu. "POEMS Syndrome Complicated by Extensive Calciphylaxis: A Remarkable Recovery." Journal of Cutaneous Medicine and Surgery 19, no. 3 (March 11, 2015): 309–12. http://dx.doi.org/10.2310/7750.2014.14086.

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Background and Objective Calciphylaxis is life threatening. It has traditionally been associated with end-stage renal disease and hyperparathyroidism but is increasingly common in other clinical contexts. The association of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and calciphylaxis has been reported only in a few cases. This case is the first of patient survival in such widespread disease. Methods and Results A 42-year-old man with POEMS syndrome developed extensive calciphylaxis despite normal renal and parathyroid function. Rapid diagnosis, treatment, and supportive care contributed to full clinical resolution. Conclusion This is the fifth case of POEMS syndrome associated with calciphylaxis. The observations from this report suggest that POEMS syndrome might be an independent risk factor for the development of calciphylaxis. This case underlines the importance of careful follow-up in patients with POEMS syndrome and prompt diagnosis and treatment of associated calciphylaxis.

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Văcăraș, Vitalie, Aida Asaftei, Nicu Cătălin Drăghici, Mihnea Zdrenghea, and Dafin Fior Mureșanu. "POEMS syndrome misdiagnosed as CIDP: A case report." Balneo and PRM Research Journal 14, Vol.14, no.2 (June 23, 2023): 558. http://dx.doi.org/10.12680/balneo.2022.558.

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POEMS syndrome is a paraneoplastic disorder manifested by peripheral neuropathy and monoclonal plasma cell dyscrasia. Due to its clinical and electrophysiological aspect, POEMS syndrome is often mistaken as a chronic inflammatory demyelinating polyneuropathy (CIDP) [1]. Its acronym is derived from its principal characteristics: polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes [2]. The purpose of this paper is to present the case of a patient who was lately diagnosed with POEMS syndrome after he was mistreated for CIDP in order to show the importance of a complete physical examination. Keywords: POEMS syndrome, demyelinating polyneuropathy, monoclonal plasma cell disorder, skin changes, vascular endothelial growth factor.

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Sonika Mayanglambam, LH Ghotekar, Madhur Yadav, Shivraj Meena, Shubham Goswami, and Bangkim Kshetrimayum. "POEMS syndrome masquearading as Tuberculosis." International Journal of Science and Research Archive 8, no. 1 (February 28, 2023): 954–59. http://dx.doi.org/10.30574/ijsra.2023.8.1.0179.

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POEMS syndrome, also called Osteosclerotic myeloma or Takatsuki syndrome or Crow-Fukase syndrome, is a rare multisystemic disease paraneoplastic syndrome under the plasma cell dyscrasias. POEMS is an acronym for Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein elevation, and skin changes. It is usually 1.5 times more common in male than female. Patients often present in the fifth to sixth decades of life and have a median survival rate of 8 to 14 years without successful treatment. Here we described a case of POEMS syndrome in a young 30 years old adult who presented with anasarca, polyneuropathy as initial manifestation and masquerading as tuberculosis. He was successfully treated with Melphalan-Dexamethasone therapy with clinical improvement. Therefore, patients with unexplained polyneuropathy especially when it is associated with endocrinopathy, skin changes or oedema, should be evaluated for POEMS syndrome.

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