Academic literature on the topic 'Podophyllotoxine – analogues et dérivés'
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Journal articles on the topic "Podophyllotoxine – analogues et dérivés":
Labidalle, S. "Analogues morphiniques dérivés des tétra- et hexahydrodibenzofurannes." European Journal of Medicinal Chemistry 24, no. 4 (August 1989): 385–90. http://dx.doi.org/10.1016/0223-5234(89)90082-2.
Buu-Hoï, Ng Ph. "La p-Hydroxypropiophénone, Ses Analogues et Leurs Dérivés." Recueil des Travaux Chimiques des Pays-Bas 68, no. 8 (September 2, 2010): 759–80. http://dx.doi.org/10.1002/recl.19490680811.
Tinant, B., A. Parfonry, and J. P. Declercq. "Structure Géométrique Et Électronique De Trois Dérivés Analogues Du Butanedinitrile-1,4." Bulletin des Sociétés Chimiques Belges 97, no. 11-12 (September 1, 2010): 883–92. http://dx.doi.org/10.1002/bscb.19880971112.
Benazeth, S., D. Bazin, B. Viossat, H. Dexpert, P. Lamelle, and Nguyen-Huy Dung. "Composés du Pt(II) à visée antitumorale, dérivés de l’ellipticine et de ses analogues." Journal de Chimie Physique 86 (1989): 1635–42. http://dx.doi.org/10.1051/jcp/1989861635.
Aubagnac, Jean-Louis, Françoise Debart, Driss Mrani, Gilles Gosselin, Bernard Rayner, and Jean-Louis Imbach. "Caractérisation de nouveaux dérivés et analogues de la nétropsine et identification de leurs intermédiaires de synthèse par spectrométrie de masse FAB." Journal of Heterocyclic Chemistry 28, no. 1 (January 1991): 145–51. http://dx.doi.org/10.1002/jhet.5570280126.
Pirotte, B., G. Dive, J. Delarge, B. Masereel, L. Dupont, L. Thunus, M. Schynts, J. Coyette, and JM Frère. "Synthèse, étude théorique et évaluation biologique de dérivés du 4-amino-4H-1,2,4-triazole analogues des antibiotiques β-lactamiques." European Journal of Medicinal Chemistry 27, no. 3 (April 1992): 193–205. http://dx.doi.org/10.1016/0223-5234(92)90003-j.
Jaeger, F. M. "Sur les éthers-sels des acides gras avec les deux Phytostérines de la graisse de Calabar, et sur les dérivés analogues de la Cholestérine, qui possèdent trois phases liquides stables." Recueil des Travaux Chimiques des Pays-Bas et de la Belgique 26, no. 9 (September 3, 2010): 311–56. http://dx.doi.org/10.1002/recl.19070260902.
Dissertations / Theses on the topic "Podophyllotoxine – analogues et dérivés":
Mouton, Carole. "La podophyllotoxine et ses dérivés inhibant la polymérisation de la tubuline et/ ou l'ADN-topoisomérase II." Paris 5, 1994. http://www.theses.fr/1994PA05P153.
Nguyen, Dinh Vu. "Synthèse de composés antidépresseurs et anticancéreux - Contribution méthodologique à la réactivité des époxydes et des dérivés organiques du bismuth." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS374/document.
My PhD thesis mainly involves the enantioselective synthesis of the Milnacipran's analog, a trisubstituted cyclobutane bearing two contiguous stereogenic centers. We have devised a conventional approach which consists of an intramolecular SN2 cyclization. After an acidic treatment, the key intermediate lactone was isolated with an ee > 99%, which was converted to the Milnacarre with no erosion of the ee value. We have also interested in the nanometric formulation of Podophyllotoxine derivatives. The natural product was designed to bear a hydrophilic and hydrophobic side chain. Its micellar solution was evaluated in vitro, in vivo and the obtained resuls were shown to be promising.We have also studied two methodologies: the reactivity of glycidyl ether toward alkyllithium reagents and oxydation of hydroxylamines to nitrone using triphenylbismuth carbonate. We observed in the former case an original rearrangement of the substrate to a vicinal diol, while in the latter case we have developped a mild condition to perform an tandem oxydation/1,3-dipolar cycloaddition in situ with a strained alkyne
Aillerie, Alexandre. "Organocatalyse : réduction asymétrique par transfert d’hydrogène et synthèse de nouveaux catalyseurs." Thesis, Lille 1, 2014. http://www.theses.fr/2014LIL10185.
The control of chirality is crucial in the synthesis of chiral active biologically molecules. Numerous chiral tetrahydroquinolines have revealed outstanding biological activities, particularly in the treatment of cancer. One of the asymmetric reduction systems to access these compounds of medicinal interest combines an organic hydride source and a chiral Brønsted acid catalyst. This system is based on a biomimetic approach of NADH and NADPH cofactors involved in many redox metabolisms. Following this methodology in agreement with the sustainable development, various enantiopure nitrogen-based heterocycles have been prepared as potential anticancer drugs. The first enantioselective synthesis of 4-azapodophyllotoxine derivatives using this reduction process has been set up. An innovative methodology, based on the possibility to generate in situ the hydride source has also been developed. Moreover, news organocatalysts derived from phospholanic acid and ferrocene have also been synthesized and evaluated within chemical transformations
Meneyrol, Jérôme. "Synthèse de nouveaux hétérolignanes dérivés de la podophyllotoxine en séries 1-Aza et 4-Aza." Paris 5, 2001. http://www.theses.fr/2001PA05P626.
Schmitt, Benoît. "5,6,7,8-tétrahydro-1,6-naphtyridines : dérivés et analogues structuraux." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13210.
Maiga, Soufiana. "Synthèse et études photobiologique et pyronocoumarines, analogues des psoralènes." Paris 11, 1991. http://www.theses.fr/1991PA114843.
MERESSE, PHILIPPE. "Conception, synthese et evaluation biologique d'agents antitumoraux : analogues structuraux de l'etoposide, de la podophyllotoxine et de la 4-demethylepipodophyllotoxine." Paris 6, 2000. http://www.theses.fr/2000PA066327.
Simon, Gaëlle. "Analogues et dérivés des méridianines : Synthèse et Étude structure-activité biologique." Brest, 2004. http://www.theses.fr/2004BRES2011.
The marine environment constitues a very promising source for novel and bioactive molecules, and meridianins have been identified among those recently discovered. These indoles with a 2-aminopyrimidine at C-3 can inhibit cyclin-dependent kinases. In order to conduct additionnal biological tests about these 3-(2-aminopyrimidine)indoles, we first synthesised NH meridianin-analogues through two routes: (i) a Miyaura-Suzuki coupling of indol-3-ylboronic acids to 2-amino-4-chloropyrimidine, and (ii) the formation of a 2-amino-pyrimidine by guanidine condensation with enaminones issued from the reaction of N,N-dimethylformamide dimethylacetal (DMF-DMA) with 3-acetylindoles. Then, in a second stage we prepared N-alkyled derivatives of meridianins by applying the same linear synthesis, using pyrrolidine for the formation of enaminones. At last, various derivatives were prepared by replacing the indole with the 1,2,3,9-tetrahydro-4H-carbazol-4-one cycle or using various pyrimidines. Some of these molecules were finally tested against cyclin-dependent kinases (GSK-3 and CDK1) and cell lines (RAJI, DAUDI and K562) as part of cancer-related researches. Other tests about the fixation of barnacle larvae were also performed to investigate the antifouling properties of these new molecules
Bayrakdar, Hassan. "Synthèse et activité biologique (spectre antibactérien, inhibition de l'ADN gyrase) d'analogues ouverts et monocycliques des quinolones." Nancy 1, 1992. http://docnum.univ-lorraine.fr/public/SCD_T_1992_0428_BAYRAKDAR.pdf.
Duca, Maria. "Nouveaux inhibiteurs de topoisomérase II dérivés de la 4'-déméthylépipodophyllotoxine dirigés sur des séquences spécifiques de l'ADN : conception, synthèse et applications." Paris, Muséum national d'histoire naturelle, 2005. http://www.theses.fr/2005MNHN0008.
DNA topoisomerase II is an ubiquitous and essential enzyme that modulates DNA topology by passing an intact DNA double helix through a transient double-stranded break. This enzyme plays critical roles in a number of DNA processes. Topoisomerase II is the primary cellular target for a large number of anticancer agents, like 4'-demethylepipodophillotoxin derivatives. These molecules stabilise the DNA/TopoII complex, and induce DNA breaks. This action converts topoisomerase II into a potent cellular toxin that fragments the genome and induces cell death. Among 4'-demethylepipodophyllotoxin derivatives, etoposide is widely used in anticancer therapy, however it presents several limitations, such as poor water solubility, development of drug resistance, metabolic inactivation and toxic effects. Therefore, we synthesized new series of etoposide analogs by introducing different substituents in 4-position, like carbamate or sulfonamide chains. Then we evaluated the effect on topoisomerase II and the cytotoxicity. The conjugation of antitumor agents, such as topoisomerase I inhibitors, allowed to direct the cleavage mediated by topoisomerase I to specific sites of the genome. On this basis we synthesized new conjgates between the new topoisomerase II inhibitors and triplex forming oligonucletides (TFO) and evaluated their ability to recruit topoisomerase II and direct its cleavage to specific DNA sequences. This targeting strategy allows to obtain topoisomerase II-mediated DNA cleavage at specific sequences of DNA, like a gene involved in cancer development. We choose to target mdr1 gene which is responsible of multidrug resistance. We obtained the inhibition of its expression by using a conjugate TFO-daunorubicine. These conjugates are also a biochemical tool to study the molecular mechanism of action of etoposide and its analogs
Books on the topic "Podophyllotoxine – analogues et dérivés":
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc, Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens... Creative Media Partners, LLC, 2018.
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc: Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens. Creative Media Partners, LLC, 2018.
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc, Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens... Creative Media Partners, LLC, 2022.
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc, Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens... Creative Media Partners, LLC, 2022.
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc, Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens... Creative Media Partners, LLC, 2018.
Pihan, Antoine Paulin. Dictionnaire Étymologique des Mots de la Langue Française dérivés de l'arabe, du Persan Ou du Turc: Avec Leurs Analogues Grecs, Latins, Espagnols, Portugais et Italiens. Creative Media Partners, LLC, 2018.
Mensink, H. Glyphosate (Environmental Health Criteria , No 159). World Health Organization, 1994.