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Relevant bibliographies by topics / Pneumonia Prevention; Pneumonia Papua New Guinea

Academic literature on the topic 'Pneumonia Prevention; Pneumonia Papua New Guinea'

Author: Grafiati

Published: 10 December 2022

Last updated: 29 January 2023

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Journal articles

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Journal articles on the topic "Pneumonia Prevention; Pneumonia Papua New Guinea"

1

Barnes, D. J., S. Naraqi, and J. D. Igo. "Community-Acquired Acinetobacter Pneumonia in Adults in Papua New Guinea." Clinical Infectious Diseases 10, no. 3 (May 1, 1988): 636–39. http://dx.doi.org/10.1093/clinids/10.3.636.

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2

SHANN, FRANK, DONALD MACGREGOR, JOHN RICHENS, and JOHN COAKLEY. "Cardiac failure in children with pneumonia in Papua New Guinea." Pediatric Infectious Disease Journal 17, no. 12 (December 1998): 1141–43. http://dx.doi.org/10.1097/00006454-199812000-00008.

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3

Witt, C. S., and M. P. Alpers. "Immune function in adult highland Papua New Guinea patients with pneumonia." Transactions of the Royal Society of Tropical Medicine and Hygiene 83, no. 2 (March 1989): 269–74. http://dx.doi.org/10.1016/0035-9203(89)90677-9.

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4

Groves, V. J., D. Lehmann, and G. L. Gilbert. "Seroepidemiology of cryptosporidiosis in children in Papua New Guinea and Australia." Epidemiology and Infection 113, no. 3 (December 1994): 491–99. http://dx.doi.org/10.1017/s0950268800068503.

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SUMMARYEnzyme immunoassays (EIA) were used to measure serum antibodies to Cryptosporidium in four immunocompetent adults with recent proven cryptosporidial infection, 379 healthy children and 73 adult volunteers in Melbourne, Australia, and 205 children in Papua New Guinea (PNG) (47 healthy children; 158 with pneumonia). Antibodies peaked 3–6 weeks after infection and fell to baseline within a few months. A high level (5000 EIA units/ml) or a significant change between paired sera, of IgG or IgM, were taken as evidence of recent infection and found in 24% of PNG children and in 8% of children and 5% of adults in Melbourne. Among PNG children with pneumonia who had high cryptosporidial antibody levels, those with measles (6/8) were significantly more likely (P = 0·002) to have diarrhoea than the remainder (4/28). Symptomatic cryptosporidiosis may be associated with transient immune suppression due to viral infection. This study indicates that serological surveys can contribute to an understanding of the epidemiology of cryptosporidosis.

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5

Pomat, W. S., T. A. Smith, R. C. Sanders, C. S. Witt, J. Montgomery, D. Lehmann, and M. P. Alpers. "Levels of anti-pneumococcal antibodies in young children in Papua New Guinea." Epidemiology and Infection 111, no. 1 (August 1993): 109–19. http://dx.doi.org/10.1017/s0950268800056739.

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SummaryAnti-pneumococcal polysaccharide antibody (anti-PPS) levels were measured in 153 serum samples collected from children aged between 2 and 47 months living in the highlands of Papua New Guinea (PNG). Fifty-seven of the samples were collected during acute episodes of lower respiratory tract infection (ALRI). Total IgA and IgG increased steadily with age; however, no association was found between the levels of these antibodies and the health status of the child. Total IgM levels showed little relationship to the age of the child but under 12 months of age levels were somewhat higher on average in children with pneumonia. For most of eight pneumococcal serotypes tested, specific IgG levels were found to decline rapidly in the first 6–8 months, reaching a minimum at approximately 12 months of age. Serotype 3 was exceptional in having very low titres in the youngest children. A separate analysis of 24 cord sera suggested that antibodies to this serotype do not usually cross the placenta in PNG. Children with pneumonia tended to have lower levels of specific IgG than healthy controls of the same age. Specific anti-PPS IgA levels were found to increase steadily with age, but were not associated with health status.

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6

Duke, Trevor, Francis Wandi, Merilyn Jonathan, Sens Matai, Magdalene Kaupa, Martin Saavu, Rami Subhi, and David Peel. "Improved oxygen systems for childhood pneumonia: a multihospital effectiveness study in Papua New Guinea." Lancet 372, no. 9646 (October 2008): 1328–33. http://dx.doi.org/10.1016/s0140-6736(08)61164-2.

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7

Walker, Emma C., Rashmi Ramani, Sarah Javati, Elizabeth Todd, Pallavi Chandra, John-Paul Matlam, Edgar Anaya, William Pomat, and Sharon Celeste Morley. "A novel variant in ubiquinone biosynthesis highly prevalent in Papua New Guinea children increases mortality following bacterial pneumonia." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 231.5. http://dx.doi.org/10.4049/jimmunol.204.supp.231.5.

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Abstract To identify immune variants predisposing to severe pneumonia, we performed whole exome sequencing in a pediatric population highly susceptible to acute lower respiratory infections, identifying a candidate novel variant in the ubiquinone (CoQ10) biosynthetic pathway. To evaluate the effect of this variant on immune function during bacterial pneumonia, we generated a mouse line using CRISPR-Cas9 that expresses the homologous aspartate to tyrosine variant in the enzyme COQ6. Intra-tracheal S. pneumoniae infection leads to increased bacteremia and mortality in mice homozygous for the variant despite similar numbers of immune cells in the lung. Mechanistic studies show that macrophages expressing the variant have decreased mitochondrial activity at the ubiquinone-dependent reduction of cytochrome c by complex III, as well as decreased maximum respiratory capacity in response to acute stimulation. Variant-expressing macrophages also exhibit impaired generation of mitochondrial reactive oxygen species (mROS) causing a direct, intrinsic defect in intracellular killing of internalized bacteria. Thus, the novel variant in CoQ10 biosynthesis leads to changes in macrophage mitochondria and an intrinsic inability to kill internalized bacteria. As alveolar macrophages are the first responders in the lung to bacterial challenge, the inability of these macrophages to mount a sufficient immune response can explain the observed increase in mortality following bacterial pneumonia. Because variants in CoQ10 biosynthesis can be supplemented with CoQ10, a readily available therapy may be able to correct this defect and improve survival in children with this variant

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8

Kim, Jinseob, Jong-Hun Kim, Hae-Kwan Cheong, Ho Kim, Yasushi Honda, Mina Ha, Masahiro Hashizume, Joel Kolam, and Kasis Inape. "Effect of Climate Factors on the Childhood Pneumonia in Papua New Guinea: A Time-Series Analysis." International Journal of Environmental Research and Public Health 13, no. 2 (February 15, 2016): 213. http://dx.doi.org/10.3390/ijerph13020213.

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9

Spooner, V., J. Barker, S. Tulloch, D. Lehmann, T. F. d. C. Marshall, M. Kajoi, and M. P. Alpers. "Clinical Signs and Risk Factors Associated with Pneumonia in Children Admitted to Goroka Hospital, Papua New Guinea." Journal of Tropical Pediatrics 35, no. 6 (December 1, 1989): 295–300. http://dx.doi.org/10.1093/tropej/35.6.295.

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10

Anga, G., J. D. Vince, and M. Kaupa. "Early Introduction of Solids and Pneumonia in Young Infants in Papua New Guinea: A Case Control Study." Journal of Tropical Pediatrics 54, no. 3 (October 15, 2007): 192–95. http://dx.doi.org/10.1093/tropej/fmm102.

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