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Journal articles on the topic 'Pneumatically assisted desorption/ionization'

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Author: Grafiati

Published: 11 March 2023

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1

Duncan, Kyle D., Hilde-Marléne Bergman, and Ingela Lanekoff. "A pneumatically assisted nanospray desorption electrospray ionization source for increased solvent versatility and enhanced metabolite detection from tissue." Analyst 142, no. 18 (2017): 3424–31. http://dx.doi.org/10.1039/c7an00901a.

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2

Mavroudakis, Leonidas, and Ingela Lanekoff. "Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System." Metabolites 13, no. 2 (February 14, 2023): 278. http://dx.doi.org/10.3390/metabo13020278.

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Gaining a deep understanding of the molecular mechanisms underlying ischemic stroke is necessary to develop treatment alternatives. Ischemic stroke is known to cause a cellular energy imbalance when glucose supply is deprived, enhancing the role for energy production via β-oxidation where acylcarnitines are essential for the transportation of fatty acids into the mitochondria. Although traditional bulk analysis methods enable sensitive detection of acylcarnitines, they do not provide information on their abundances in various tissue regions. However, with quantitative mass spectrometry imaging the detected concentrations and spatial distributions of endogenous molecules can be readily obtained in an unbiased way. Here, we use pneumatically assisted nanospray desorption electrospray ionization mass spectrometry imaging (PA nano-DESI MSI) doped with internal standards to study the distributions of acylcarnitines in mouse brain affected by stroke. The internal standards enable quantitative imaging and annotation of endogenous acylcarnitines is achieved by studying fragmentation patterns. We report a significant accumulation of long-chain acylcarnitines due to ischemia in brain tissue of the middle cerebral artery occlusion (MCAO) stroke model. Further, we estimate activities of carnitine transporting enzymes and demonstrate disruptions in the carnitine shuttle system that affects the β-oxidation in the mitochondria. Our results show the importance for quantitative monitoring of metabolite distributions in distinct tissue regions to understand cell compensation mechanisms involved in handling damage caused by stroke.

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3

Lu, I.-Chung, Chuping Lee, Yuan-Tseh Lee, and Chi-Kung Ni. "Ionization Mechanism of Matrix-Assisted Laser Desorption/Ionization." Annual Review of Analytical Chemistry 8, no. 1 (July 22, 2015): 21–39. http://dx.doi.org/10.1146/annurev-anchem-071114-040315.

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4

Liu, Bo-Hong, Oleg P. Charkin, Nina Klemenko, Chiu Wen Chen, and Yi-Sheng Wang. "Initial Ionization Reaction in Matrix-Assisted Laser Desorption/Ionization." Journal of Physical Chemistry B 114, no. 33 (August 26, 2010): 10853–59. http://dx.doi.org/10.1021/jp104178m.

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5

Dattelbaum, Andrew M., and Srinivas Iyer. "Surface-assisted laser desorption/ionization mass spectrometry." Expert Review of Proteomics 3, no. 1 (February 2006): 153–61. http://dx.doi.org/10.1586/14789450.3.1.153.

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6

Michalak, Leszek, Keith J. Fisher, David S. Alderdice, Daniel R. Jardine, and Gary D. Willett. "C60-assisted laser desorption-ionization mass spectrometry." Organic Mass Spectrometry 29, no. 9 (September 1994): 512–15. http://dx.doi.org/10.1002/oms.1210290912.

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7

Özdemir, Abdil, and Chung-Hsuan Chen. "Electrode-assisted desorption electrospray ionization mass spectrometry." Journal of Mass Spectrometry 45, no. 10 (September 20, 2010): 1203–11. http://dx.doi.org/10.1002/jms.1815.

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8

Karbach, Volker, Richard Knochenmuss, and Renato Zenobi. "Matrix-assisted filament desorption/ionization mass spectrometry." Journal of the American Society for Mass Spectrometry 9, no. 11 (November 1998): 1226–28. http://dx.doi.org/10.1016/s1044-0305(98)00099-3.

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9

Karas, Michael, Ute Bahr, and Ulrich Gießmann. "Matrix-assisted laser desorption ionization mass spectrometry." Mass Spectrometry Reviews 10, no. 5 (September 1991): 335–57. http://dx.doi.org/10.1002/mas.1280100503.

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10

Tarka, Mark. "Is laser desorption/ionization TOFMS field-assisted?" Rapid Communications in Mass Spectrometry 13, no. 10 (May 30, 1999): 975. http://dx.doi.org/10.1002/(sici)1097-0231(19990530)13:10<975::aid-rcm582>3.0.co;2-q.

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11

Bakhtiar, Ray, and Randall W. Nelson. "Electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry." Biochemical Pharmacology 59, no. 8 (April 2000): 891–905. http://dx.doi.org/10.1016/s0006-2952(99)00317-2.

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12

Hiraoka, Kenzo. "Laser spray: electric field-assisted matrix-assisted laser desorption/ionization." Journal of Mass Spectrometry 39, no. 4 (April 2004): 341–50. http://dx.doi.org/10.1002/jms.621.

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13

Weidner, Steffen, Gerhard Kühn, and Jörg Friedrich. "Infrared-matrix-assisted laser desorption/ionization and infrared-laser desorption/ionization investigations of synthetic polymers." Rapid Communications in Mass Spectrometry 12, no. 19 (October 15, 1998): 1373–81. http://dx.doi.org/10.1002/(sici)1097-0231(19981015)12:19<1373::aid-rcm325>3.0.co;2-n.

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14

Tsai, S. T., C. H. Chen, Y. T. Lee, and Y. S. Wang. "Desorption dynamics of neutral molecules in matrix-assisted laser desorption/ionization." Molecular Physics 106, no. 2-4 (February 2008): 239–47. http://dx.doi.org/10.1080/00268970701779671.

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15

Merrigan, Tony L., C. Adam Hunniford, David J. Timson, Martin Catney, and Robert W. McCullough. "Development of a novel mass spectrometric technique for studying DNA damage." Biochemical Society Transactions 37, no. 4 (July 22, 2009): 905–9. http://dx.doi.org/10.1042/bst0370905.

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An experimental system, based upon UV and IR laser desorption, has been constructed to enable the production and characterization of neutral biomolecular targets. These targets are to be used for interaction experiments investigating radiation-induced damage to DNA. The viability of the laser-desorption techniques of MALDI (matrix-assisted laser-desorption ionization), SALDI (surface-assisted laser-desorption ionization) and DIOS (desorption/ionization on silicon), for production of these gas targets is discussed in the present paper. Fluorescent dye tagging and LIF (laser-induced fluorescence) imaging has been used to characterize the biomolecular plumes, revealing their spatial density profiles and temporal evolution.

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16

McCarley, Tracy Donovan, Robin L. McCarley, and Patrick A. Limbach. "Electron-Transfer Ionization in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry." Analytical Chemistry 70, no. 20 (October 1998): 4376–79. http://dx.doi.org/10.1021/ac980527i.

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17

Usmanov, D. T., K. Hiraoka, H. Wada, S. Morita, and H. Nonami. "Desorption of low-volatility compounds induced by dynamic friction between microdroplets and an ultrasonically vibrating blade." Analyst 141, no. 4 (2016): 1398–404. http://dx.doi.org/10.1039/c5an02215k.

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Friction plays an important role in desorption and/or ionization of nonvolatile compounds in mass spectrometry, e.g., sonic spray, easy ambient sonic-spray ionization, solvent-assisted inlet ionization, desorption electrospray, etc.

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18

TAIRA, Shu, and Hajime KATANO. "Nano-Particle Assisted Laser Desorption/Ionization Mass Spectrometry." Journal of the Mass Spectrometry Society of Japan 64, no. 5 (2016): 197–200. http://dx.doi.org/10.5702/massspec.s16-41.

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19

Osaka, Issey. "Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging." Journal of the Mass Spectrometry Society of Japan 67, no. 4 (August 1, 2019): 117–22. http://dx.doi.org/10.5702/massspec.s19-27.

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20

Zaima, Nobuhiro, Takahiro Hayasaka, Naoko Goto-Inoue, and Mitsutoshi Setou. "Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry." International Journal of Molecular Sciences 11, no. 12 (December 7, 2010): 5040–55. http://dx.doi.org/10.3390/ijms11125040.

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21

Duncan, M. W., H. Roder, and S. W. Hunsucker. "Quantitative matrix-assisted laser desorption/ionization mass spectrometry." Briefings in Functional Genomics and Proteomics 7, no. 5 (June 25, 2008): 355–70. http://dx.doi.org/10.1093/bfgp/eln041.

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22

Bryson, Alexandra L., Emily M. Hill, and Christopher D. Doern. "Matrix-Assisted Laser Desorption/Ionization Time-of-Flight." Clinics in Laboratory Medicine 39, no. 3 (September 2019): 391–404. http://dx.doi.org/10.1016/j.cll.2019.05.010.

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23

Murray, Kermit K., and David H. Russell. "Aerosol Matrix-Assisted Laser Desorption Ionization Mass Spectrometry." Journal of the American Society for Mass Spectrometry 5, no. 1 (January 1994): 1–9. http://dx.doi.org/10.1016/1044-0305(94)85077-1.

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24

Rezenom, Yohannes H., Jianan Dong, and Kermit K. Murray. "Infrared laser-assisted desorption electrospray ionization mass spectrometry." Analyst 133, no. 2 (2008): 226–32. http://dx.doi.org/10.1039/b715146b.

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25

Knochenmuss, Richard, Edda Lehmann, and Renato Zenobi. "Polymer cationization in matrix-assisted laser desorption/ionization." European Journal of Mass Spectrometry 4, no. 1 (1998): 421. http://dx.doi.org/10.1255/ejms.266.

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26

Liao, Pao-Chi, and John Allison. "Dissecting matrix-assisted laser desorption/ionization mass spectra." Journal of Mass Spectrometry 30, no. 5 (May 1995): 763–66. http://dx.doi.org/10.1002/jms.1190300517.

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27

Chang, Wei Chao, Ling Chu Lora Huang, Yi-Sheng Wang, Wen-Ping Peng, Huan Cheng Chang, Nien Yeen Hsu, Wen Bin Yang, and Chung Hsuan Chen. "Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited." Analytica Chimica Acta 582, no. 1 (January 2007): 1–9. http://dx.doi.org/10.1016/j.aca.2006.08.062.

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28

Lu, Tian, and Susan V. Olesik. "Electrospun Nanofibers as Substrates for Surface-Assisted Laser Desorption/Ionization and Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry." Analytical Chemistry 85, no. 9 (April 26, 2013): 4384–91. http://dx.doi.org/10.1021/ac303292e.

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29

SHIGERI, Yasushi, Satoshi INAZUMI, Yoshihisa HAGIHARA, Akikazu YASUDA, Hideya KAWASAKI, Ryuichi ARAKAWA, and Makoto NAKATA. "Desorption/Ionization Efficiency of Peptides Containing Disulfide Bonds in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry." Analytical Sciences 28, no. 3 (2012): 295. http://dx.doi.org/10.2116/analsci.28.295.

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30

Okuno, Shoji, Motohiro Nakano, Gen-etsu Matsubayashi, Ryuichi Arakawa, and Yoshinao Wada. "Reduction of organic dyes in matrix-assisted laser desorption/ionization and desorption/ionization on porous silicon." Rapid Communications in Mass Spectrometry 18, no. 23 (2004): 2811–17. http://dx.doi.org/10.1002/rcm.1689.

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31

Molin, Laura, Roberta Seraglia, Zbigniew Czarnocki, Jan K. Maurin, Franciszek A. Pluciński, and Pietro Traldi. "On the Primary Ionization Mechanism(s) in Matrix-Assisted Laser Desorption Ionization." Journal of Analytical Methods in Chemistry 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/161865.

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A mechanism is proposed for the first step of ionization occurring in matrix-assisted laser desorption ionization, leading to protonated and deprotonated matrix (Ma) molecules ([Ma+H]+and[Ma-H]-ions). It is based on observation that in solid state, for carboxyl-containing MALDI matrices, the molecules form strong hydrogen bonds and their carboxylic groups can act as both donors and acceptors. This behavior leads to stable dimeric structures. The laser irradiation leads to the cleavage of these hydrogen bonds, and theoretical calculations show that both[Ma+H]+and[Ma-H]-ions can be formed through a two-photon absorption process. Alternatively, by the absorption of one photon only, a heterodissociation of one of the O–H bonds can lead to a stable structure containing both cationic and anionic sites. This structure could be considered an intermediate that, through the absorption of a further photon, leads to the formation of matrix ions. Some experiments have been performed to evaluate the role of thermal ionization and indicate that its effect is negligible. Some differences have been observed for different matrices in the formation of analyte molecule (M) ion[M+H]+,[M-H]-,M+•, and[M-2H]-•, and they have been explained in terms of ionization energies, pKa values, and thermodynamic stability.

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32

Rivera-Tirado, Edgardo, and Chrys Wesdemiotis. "Characterization of polyethylenimine by electrospray ionization and matrix-assisted laser desorption/ionization." Journal of Mass Spectrometry 46, no. 9 (September 2011): 876–83. http://dx.doi.org/10.1002/jms.1964.

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33

Allwood, D. A., P. E. Dyer, and R. W. Dreyfus. "Ionization Modelling of Matrix Molecules in Ultraviolet Matrix-assisted Laser Desorption/Ionization." Rapid Communications in Mass Spectrometry 11, no. 5 (March 1997): 499–503. http://dx.doi.org/10.1002/(sici)1097-0231(199703)11:5<499::aid-rcm880>3.0.co;2-2.

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34

Lin, Qiong, and Richard Knochenmuss. "Two-photon ionization thresholds of matrix-assisted laser desorption/ionization matrix clusters." Rapid Communications in Mass Spectrometry 15, no. 16 (2001): 1422–26. http://dx.doi.org/10.1002/rcm.380.

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35

Song, Kyuseok, and Quan Cheng. "Desorption and ionization mechanisms and signal enhancement in surface assisted laser desorption ionization mass spectrometry (SALDI-MS)." Applied Spectroscopy Reviews 55, no. 3 (February 26, 2019): 220–42. http://dx.doi.org/10.1080/05704928.2019.1570519.

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36

Abdelhamid, Hani Nasser. "Nanocytotoxicity using matrix-assisted laser desorption ionization mass spectrometry." Future Microbiology 15, no. 6 (April 2020): 385–87. http://dx.doi.org/10.2217/fmb-2019-0260.

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37

Karas, M. "Matrix-assisted laser desorption ionization MS: a progress report." Biochemical Society Transactions 24, no. 3 (August 1, 1996): 897–900. http://dx.doi.org/10.1042/bst0240897.

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38

Hillenkamp, Franz, Michael Karas, Ronald C. Beavis, and Brian T. Chait. "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Biopolymers." Analytical Chemistry 63, no. 24 (December 15, 1991): 1193A—1203A. http://dx.doi.org/10.1021/ac00024a716.

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39

Li, Liang, Alan P. L. Wang, and Larry D. Coulson. "Continuous-flow matrix-assisted laser desorption ionization mass spectrometry." Analytical Chemistry 65, no. 4 (February 15, 1993): 493–95. http://dx.doi.org/10.1021/ac00052a029.

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40

Woods, A. S., J. C. Buchsbaum, T. A. Worrall, J. M. Berg, and R. J. Cotter. "Matrix-Assisted Laser Desorption/Ionization of Noncovalently Bound Compounds." Analytical Chemistry 67, no. 24 (December 1995): 4462–65. http://dx.doi.org/10.1021/ac00120a005.

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41

Laiko, Victor V., Michael A. Baldwin, and Alma L. Burlingame. "Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry." Analytical Chemistry 72, no. 4 (February 2000): 652–57. http://dx.doi.org/10.1021/ac990998k.

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42

Murray, Kermit K., and David H. Russell. "Liquid sample introduction for matrix-assisted laser desorption ionization." Analytical Chemistry 65, no. 18 (September 15, 1993): 2534–37. http://dx.doi.org/10.1021/ac00066a023.

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43

West, Raymond E., Eric W. Findsen, and Dragan Isailovic. "Fluorophore-assisted laser desorption/ionization-mass spectrometry (FALDI-MS)." International Journal of Mass Spectrometry 353 (November 2013): 54–59. http://dx.doi.org/10.1016/j.ijms.2013.07.004.

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44

Lee, Chuping, and Chi-Kung Ni. "Soft Matrix–Assisted Laser Desorption/Ionization for Labile Glycoconjugates." Journal of The American Society for Mass Spectrometry 30, no. 8 (April 16, 2019): 1455–63. http://dx.doi.org/10.1007/s13361-019-02208-4.

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45

Dalluge, Joseph J. "Matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)." Analytical and Bioanalytical Chemistry 372, no. 1 (December 8, 2001): 18–19. http://dx.doi.org/10.1007/s00216-001-1151-4.

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46

Olumee, Zohra, and Akos Vertes. "Protonation of GlynHomologues in Matrix-Assisted Laser Desorption Ionization." Journal of Physical Chemistry B 102, no. 31 (July 1998): 6118–22. http://dx.doi.org/10.1021/jp981123x.

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47

Brown, Tracy, Nigel L. Clipston, Nafeesa Simjee, Heinrich Luftmann, Hartmut Hungerbühler, and Thomas Drewello. "Matrix-assisted laser desorption/ionization of amphiphilic fullerene derivatives." International Journal of Mass Spectrometry 210-211 (September 2001): 249–63. http://dx.doi.org/10.1016/s1387-3806(01)00429-8.

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48

Rashidezadeh, H., K. Hung, and Baochuan Guo. "Probing polystyrene cationization in matrix-assisted laser/desorption ionization." European Journal of Mass Spectrometry 4, no. 1 (1998): 429. http://dx.doi.org/10.1255/ejms.267.

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49

Harvey, D. J. "Matrix-assisted laser desorption/ionization mass spectrometry of phospholipids." Journal of Mass Spectrometry 30, no. 9 (September 1995): 1333–46. http://dx.doi.org/10.1002/jms.1190300918.

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50

Jorabchi, Kaveh, Michael S. Westphall, and Lloyd M. Smith. "Charge Assisted Laser Desorption/Ionization Mass Spectrometry of Droplets." Journal of the American Society for Mass Spectrometry 19, no. 6 (June 2008): 833–40. http://dx.doi.org/10.1016/j.jasms.2008.02.012.

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