Relevant bibliographies by topics / PNA-Peptide Conjugate

Academic literature on the topic 'PNA-Peptide Conjugate'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "PNA-Peptide Conjugate"

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Thompson, Andrew, Mark Prescott, Noorhan Chelebi, John Smith, Tom Brown, and Günter Schmidt. "Electrospray ionisation-cleavable tandem nucleic acid mass tag–peptide nucleic acid conjugates: synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS." Nucleic Acids Research 35, no. 4 (December 9, 2006): e28-e28. http://dx.doi.org/10.1093/nar/gkl1123.

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Abstract The synthesis and characterization of isotopomer tandem nucleic acid mass tag–peptide nucleic acid (TNT–PNA) conjugates is described along with their use as electrospray ionisation-cleavable (ESI-Cleavable) hybridization probes for the detection and quantification of target DNA sequences by electrospray ionisation tandem mass spectrometry (ESI-MS/MS). ESI-cleavable peptide TNT isotopomers were introduced into PNA oligonucleotide sequences in a total synthesis approach. These conjugates were evaluated as hybridization probes for the detection and quantification of immobilized synthetic target DNAs using ESI-MS/MS. In these experiments, the PNA portion of the conjugate acts as a hybridization probe, whereas the peptide TNT is released in a collision-based process during the ionization of the probe conjugate in the electrospray ion source. The cleaved TNT acts as a uniquely resolvable marker to identify and quantify a unique target DNA sequence. The method should be applicable to a wide variety of assays requiring highly multiplexed, quantitative DNA/RNA analysis, including gene expression monitoring, genetic profiling and the detection of pathogens.
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Tan, Xin-Xing, Jeffrey K. Actor, and Yin Chen. "Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection." Antimicrobial Agents and Chemotherapy 49, no. 8 (August 2005): 3203–7. http://dx.doi.org/10.1128/aac.49.8.3203-3207.2005.

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ABSTRACT Antisense oligodeoxynucleotides (ODNs) and their analogs have been successfully utilized to inhibit gene expression and bacterial growth in vitro or in cell culture. In this study, acpP-targeting antisense peptide nucleic acid (PNA) and its peptide conjugate were tested as potential antibacterial agents in two groups of experiments using a mouse model. In the first group, Escherichia coli mutant strain SM101 with a defective outer membrane was used to induce bacteremia and peritonitis in BALB/c mice by intraperitoneal (i.p.) injection. The resulting bacteremia was fatal within 48 h. A single i.p injection of 5 nmol (or more) of PNA administered 30 min before bacterial challenge significantly reduced the bacterial load in mouse blood. Reductions in serum concentrations of the proinflammatory cytokines tumor necrosis factor alpha, interleukin-1β (IL-1β), IL-6, and IL-12 were also observed. PNA treatment was effective in rescuing 100% of infected animals. In the second group, bacteremia in BALB/c mice was induced by i.p. injection of E. coli wild-type strain K-12. The infected mice were treated by a single intravenous injection of peptide-PNA conjugate 30 min after bacterial challenge. Treatment with the peptide-PNA conjugate significantly reduced the K-12 load, with modest reduction in cytokine concentrations. The conjugate treatment was also able to rescue up to 60% of infected animals. This report is the first demonstration of ODNs' antibacterial efficacy in an animal disease model. The ability of PNA and its peptide conjugate to inhibit bacterial growth and to prevent fatal infection demonstrates the potential for this new class of antibacterial agents.
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Awasthi, Satish, and Peter Nielsen. "Parallel Synthesis of PNA-Peptide Conjugate Libraries." Combinatorial Chemistry & High Throughput Screening 5, no. 3 (May 1, 2002): 253–59. http://dx.doi.org/10.2174/1386207024607266.

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Lee, Eun Kyung, Chan Woo Kim, Hiroyuki Kawanami, Akihiro Kishimura, Takuro Niidome, Takeshi Mori, and Yoshiki Katayama. "Utilization of a PNA-peptide conjugate to induce a cancer protease-responsive RNAi effect." RSC Advances 5, no. 104 (2015): 85816–21. http://dx.doi.org/10.1039/c5ra17737e.

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Burlina, Fabienne, David D. Dixson, Robert P. Doyle, Gérard Chassaing, Christopher N. Boddy, Philip Dawson, and John Offer. "Orthogonal ligation: a three piece assembly of a PNA–peptide–PNA conjugate." Chemical Communications, no. 24 (2008): 2785. http://dx.doi.org/10.1039/b801242c.

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de Koning, Martijn C., Dmitri V. Filippov, Nico Meeuwenoord, Mark Overhand, Gijsbert A. van der Marel, and Jacques H. van Boom. "Synthesis of a PNA-Peptide Conjugate by Chemical Ligation." Synlett 2001, no. 10 (2001): 1516–18. http://dx.doi.org/10.1055/s-2001-17455.

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Proshkina, Galina, Elena Shramova, Anastasiya Ryabova, Liat Katrivas, Clelia Giannini, Daniele Malpicci, Yael Levi-Kalisman, Sergey Deyev, and Alexander Kotlyar. "Novel Small Multilamellar Liposomes Containing Large Quantities of Peptide Nucleic Acid Selectively Kill Breast Cancer Cells." Cancers 14, no. 19 (September 30, 2022): 4806. http://dx.doi.org/10.3390/cancers14194806.

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Peptide nucleic acid (PNA) may be used in various biomedical applications; however, these are currently limited, due to its low solubility in aqueous solutions. In this study, a methodology to overcome this limitation is demonstrated, as well as the effect of PNA on cell viability. We show that extruding a mixture of natural phospholipids and short (6–22 bases), cytosine-rich PNA through a 100 nm pore size membrane under mild acidic conditions resulted in the formation of small (60–90 nm in diameter) multilamellar vesicles (SMVs) comprising several (3–5) concentric lipid membranes. The PNA molecules, being positively charged under acidic conditions (due to protonation of cytosine bases in the sequence), bind electrostatically to negatively charged phospholipid membranes. The large membrane surface area allowed the encapsulation of thousands of PNA molecules in the vesicle. SMVs were conjugated with the designed ankyrin repeat protein (DARPin_9-29), which interacts with human epidermal growth factor receptor 2 (HER2), overexpressed in human breast cancer. The conjugate was shown to enter HER2-overexpressing cells by receptor-mediated endocytosis. PNA molecules, released from lysosomes, aggregate in the cytoplasm into micron-sized particles, which interfere with normal cell functioning, causing cell death. The ability of DARPin-functionalized SMVs to specifically deliver large quantities of PNA to cancer cells opens a new promising avenue for cancer therapy.
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Wen, Cui-jiao, Jia-yuan Gong, Ke-wei Zheng, Yi-de He, Jia-yu Zhang, Yu-hua Hao, and Zheng Tan. "Targeting nucleic acids with a G-triplex-to-G-quadruplex transformation and stabilization using a peptide–PNA G-tract conjugate." Chemical Communications 56, no. 48 (2020): 6567–70. http://dx.doi.org/10.1039/d0cc02102d.

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The synergy between two recognizing units in a bi-functional peptide–PNA G-tract conjugate recognizes a three guanine-tracts motif to form an extra stable bimolecular complex, resulting in highly potent and selective interference to DNA metabolism.
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Vázquez, O., and O. Seitz. "Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover." Chem. Sci. 5, no. 7 (2014): 2850–54. http://dx.doi.org/10.1039/c4sc00299g.

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Soudah, Terese, Saleh Khawaled, Rami I. Aqeilan, and Eylon Yavin. "AntimiR-155 Cyclic Peptide–PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity." ACS Omega 4, no. 9 (August 12, 2019): 13954–61. http://dx.doi.org/10.1021/acsomega.9b01697.

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Book chapters on the topic "PNA-Peptide Conjugate"

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Romanelli, Alessandra, Soccorsa Pensato, Erminia Di Niola, Giordana Feriotto, Francesca Salvatori, Giulia Breveglieri, Laura Zaccaro, et al. "Antisense PNA and PNA-peptide Conjugates for the Modulation of β-globin Gene Splicing." In Understanding Biology Using Peptides, 367–68. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-26575-9_149.

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Goltermann, Lise, and Peter E. Nielsen. "PNA Antisense Targeting in Bacteria: Determination of Antibacterial Activity (MIC) of PNA-Peptide Conjugates." In Peptide Nucleic Acids, 231–39. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0243-0_14.

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Hubrich, Barbara E., Patrick M. Menzel, Benedikt Kugler, and Ulf Diederichsen. "Synthesis of PNA-Peptide Conjugates as Functional SNARE Protein Mimetics." In Peptide Nucleic Acids, 61–74. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0243-0_4.

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Hansen, Anna Mette, Ashif Yasin Shaikh, and Henrik Franzyk. "Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage." In Peptide Nucleic Acids, 97–118. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0243-0_6.

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Schneider, James. "Peptide Nucleic Acid (PNA) Conjugates in Biotechnology." In Biomimetic Materials And Design. CRC Press, 2002. http://dx.doi.org/10.1201/9780203908976.ch19.

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"Peptide Nucleic Acid (PNA) Conjugates in Biotechnology." In Biomimetic Materials And Design, 564–92. CRC Press, 2002. http://dx.doi.org/10.1201/9780203908976-25.

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Conference papers on the topic "PNA-Peptide Conjugate"

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Ivanova, Gabriela D., Andrey A. Arzumanov, John J. Turner, Martin M. Fabani, Rachida Abes, Bernard Lebleu, and Michael J. Gait. "RNA targeting in cells by peptide conjugates of peptide nucleic acids (PNA)." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810103.

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Reports on the topic "PNA-Peptide Conjugate"

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Wilbur, Scott D. In Vitro Assessment of a Peptide Nucleic Acid (PNA) - Peptide Conjugate Labeled With an Auger-Emitting Radionuclide for Prostate Cell Killing. Fort Belvoir, VA: Defense Technical Information Center, February 2005. http://dx.doi.org/10.21236/ada435102.

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