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Journal articles on the topic 'PMIE'

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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

Williamson, Victoria, Sharon A. M. Stevelink, and Neil Greenberg. "Occupational moral injury and mental health: systematic review and meta-analysis." British Journal of Psychiatry 212, no. 6 (May 22, 2018): 339–46. http://dx.doi.org/10.1192/bjp.2018.55.

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BackgroundMany people confront potentially morally injurious experiences (PMIEs) in the course of their work which can violate deeply held moral values or beliefs, putting them at risk for psychological difficulties (e.g. post-traumatic stress disorder (PTSD), depression, etc.).AimsWe aimed to assess the effect of moral injury on mental health outcomes.MethodWe conducted a systematic review and meta-analysis to assess the association between work-related PMIEs and mental health disorders. Studies were independently assessed for methodological quality and potential moderator variables, including participant age, gender and PMIE factors, were also examined.ResultsThirteen studies were included, representing 6373 participants. PMIEs accounted for 9.4% of the variance in PTSD, 5.2% of the variance in depression and 2.0% of the variance in suicidality. PMIEs were associated with more symptoms of anxiety and behavioural problems (e.g. hostility), although this relationship was not consistently significant. Moderator analyses indicated that methodological factors (e.g. PMIE measurement tool), demographic characteristics and PMIE variables (e.g. militaryv.non-military context) did not affect the association between a PMIE and mental health outcomes.ConclusionsMost studies examined occupational PMIEs in military samples and additional studies investigating the effect of PMIEs on civilians are needed. Given the limited number of high-quality studies available, only tentative conclusions about the association between exposure to PMIEs and mental health disorders can be made.Declaration of interestNone.
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2

Levi-Belz, Y., G. Zerach, G. Schwartz, and E. Halperin. "Moral Injury and Suicide Ideation Among Combat Veterans: The Role of Trauma-Related Shame and Collective Hatred." European Psychiatry 65, S1 (June 2022): S844. http://dx.doi.org/10.1192/j.eurpsy.2022.2187.

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Introduction Exposure to potentially morally injurious events (PMIEs) among combat veterans has been acknowledged as a significant stressful combat event that may lead to mental health problems, including suicide ideation (SI). Several studies have examined the risk and protective factors that can explain the conditions in which PMIEs may contribute to the development and maintenance of SI. However, the contribution of social-emotional factors has yet to be examined. Objectives In the current study, we examined the association between PMIE-Self and SI among combat veterans and explored the mediating role of trauma-related shame and the moderation role of collective hatred in this association. Methods A volunteer sample of 336 Israeli combat veterans was recruited, completing self-report questionnaires in a cross-sectional study. Results indicated that PMIE-Self was positively associated with SI, and trauma-related shame mediated this association. Moreover, collective hatred moderated both their direct (PMIE -SI) and indirect (PMIE-Shame-SI) association. Notably, collective hatred had an inverse role for each of the associations. Thus, collective hatred was found to comprise both a risk and a protective factor for SI following PMIE-Self. Conclusions The current findings highlight the crucial contribution of trauma-related shame and collective hatred to the association between moral injury and suicidality. Moreover, the findings demonstrate that even years after their military service release, combat veterans exposed to PMIEs may still feel consumed by painful memories and maintain premonitions of a foreshortened future. Furthermore, the findings help to better understand the dynamics of collective hatred and the challenge of modifying it. Disclosure No significant relationships.
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3

Gherman, Mihaela Alexandra, Laura Arhiri, Andrei Corneliu Holman, and Camelia Soponaru. "Protective Factors against Morally Injurious Memories from the COVID-19 Pandemic on Nurses’ Occupational Wellbeing: A Cross-Sectional Experimental Study." International Journal of Environmental Research and Public Health 19, no. 18 (September 19, 2022): 11817. http://dx.doi.org/10.3390/ijerph191811817.

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The COVID-19 pandemic was a fertile ground for nurses’ exposure to self- and other-Potentially Morally Injurious Events (PMIEs). Our study explored the effects of nurses’ memories of self- and other-PMIEs on occupational wellbeing and turnover intentions. Using an experimental design on a convenience sample of 634 Romanian nurses, we tested a conceptual model with PLS-SEM, finding adequate explanatory and predictive power. Memories of self- and other-PMIEs were uniquely associated with work engagement, burnout, and turnover intentions, compared to a control group. These relationships were mediated by the three basic psychological needs. Relatedness was more thwarted for memories of other-PMIEs, while competence and autonomy were more thwarted for memories of self-PMIEs. Perceived supervisor support weakened the indirect effect between type of PMIE and turnover intentions, through autonomy satisfaction, but not through burnout. Self-disclosure weakened the indirect effect between type of PMIE and turnover intentions, through autonomy satisfaction, and both burnout and work engagement. Our findings emphasize the need for different strategies in addressing the negative long-term effects of nurses’ exposure to self- and other-PMIEs, according to the basic psychological need satisfaction and type of wellbeing indicator.
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Gherman, Mihaela Alexandra, Laura Arhiri, Andrei Corneliu Holman, and Camelia Soponaru. "The Moral Impact of the COVID-19 Pandemic on Nurses’ Burnout, Work Satisfaction and Adaptive Work Performance: The Role of Autobiographical Memories of Potentially Morally Injurious Events and Basic Psychological Needs." International Journal of Environmental Research and Public Health 19, no. 13 (June 22, 2022): 7645. http://dx.doi.org/10.3390/ijerph19137645.

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The COVID-19 pandemic resulted in unprecedented exposure to Potentially Morally Injurious Events (PMIEs) for nurses, in which they were both moral transgressors and moral victims, with deleterious consequences on their psycho-social health and functioning. Our experimental design compared memories of PMIEs with memories of severe moral transgressions (SMTs), in which participants were only moral transgressors. Drawing from Self-Determination Theory and research on moral auto-biographical episodic memories, we assessed a conceptual model describing the impact of recalling a single PMIE or SMT event on nurses’ burnout, work satisfaction and adaptive performance. Our convenience sample comprised 614 Romanian nurses, and data was analyzed with path analysis, general linear modelling, and t-tests. Findings showed that memories of PMIEs, compared to SMTs, were more autonomy thwarting, being associated with more controlled work motivation, less moral learning, higher burnout, less work satisfaction, and adaptive performance. Burnout, moral learning, and work satisfaction were significant mediators of the relationships between PMIE and SMT recall and, respectively, adaptive performance. Our results highlight the urgency for organizational practices of moral repair for nurses after the pandemic, along with interventions meant to increase their autonomy and self-determined work motivation.
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5

Yamaki, Marcos, Gilberto Romeiro de Oliveira Menezes, Rafael Bastos Teixeira, Leandro Barbosa, André Luis da Costa Paiva, and Robledo de Almeida Torres. "Divergência genética entre linhagens de matrizes de corte por meio de análise de agrupamento." Revista Brasileira de Zootecnia 37, no. 5 (May 2008): 829–33. http://dx.doi.org/10.1590/s1516-35982008000500008.

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Este trabalho foi realizado com o objetivo de avaliar a divergência genética de três linhagens de matrizes de corte do Programa de Melhoramento Genético da UFV. Foram avaliados dados de 270 aves, 90 de cada linhagem, para estudo das características dias para o primeiro ovo (DPPO), taxa de postura da 22ª à 56ª semana (TP), peso médio individual na 32ª (PMI1), 40ª (PMI2), 48ª (PMI3), 56ª (PMI4) e 64ª semanas de idade (PMI5); e peso médio do ovo, obtido pela média da pesagem de três ovos na 32ª (PMO1), 40ª (PMO2), 48ª (PMO3), 56ª (PMO4) e 64ª semanas de idade (PMO5). Para avaliar a divergência, foram utilizados dois métodos: hierárquico do vizinho mais próximo e otimização de Tocher. Pelo método hierárquico do vizinho mais próximo, utilizando-se a distância de Mahalanobis ao quadrado (D²) como medida de dissimilaridade, formou-se um único grupo. Pelo método de otimização de Tocher, foram formados dois grupos, comprovando que os dois métodos foram discordantes na avaliação da divergência genética de linhas de aves de corte. As características que apresentaram as contribuições relativas mais expressivas para a divergência foram, respectivamente, PMO1 (25,71%), DDPO (21,76%), PMI4 (17,65%) e PMI2 (13,04%).
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Paiva, André Luis da Costa, Rafael Bastos Teixeira, Marcos Yamaki, Gilberto Romeiro de Oliveira Menezes, Carla Daniela Suguimoto Leite, and Robledo de Almeida Torres. "Análise de componentes principais em características de produção de aves de postura." Revista Brasileira de Zootecnia 39, no. 2 (February 2010): 285–88. http://dx.doi.org/10.1590/s1516-35982010000200009.

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Para avaliar a possibilidade de descarte de variáveis de produção em 942 aves de postura por meio de componentes principais, visando eliminar características redundantes e de difícil mensuração, foram utilizados os dados obtidos de linhagens de aves de postura do Programa de Melhoramento Genético da Universidade Federal de Viçosa. As características analisadas foram: taxa de postura da 26ª à 58ª semana de idade (TP); peso médio individual na 34ª (PMI1), na 42ª (PMI2), na 50ª (PMI3), na 58ª (PMI4) e na 66ª semana (PMI5); e peso médio do ovo na 34ª (PMO1), na 42ª (PMO2), na 50ª (PMO3), na 58ª (PMO4) e na 66ª semana de idade (PMO5). Dos 11 componentes principais, oito apresentaram variância inferior a 0,7 (autovalor inferior a 0,7), o que sugere oito variáveis para descarte. As variáveis descartadas foram aquelas com maiores coeficientes, em valor absoluto, a partir do último componente principal, uma vez que variáveis altamente correlacionadas aos componentes principais de menor variância representam variação praticamente insignificante. As variáveis descartadas apresentaram correlação linear simples significativa com as demais, ou seja, foram redundantes. Com base nesses resultados, recomendam-se as seguintes variáveis para utilização em experimentos futuros: TP, PMI1 e PMO4.
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Marth, Christina D., Simon M. Firestone, Dave Hanlon, Lisa Y. Glenton, Glenn F. Browning, Neil D. Young, and Natali Krekeler. "Innate immune genes in persistent mating-induced endometritis in horses." Reproduction, Fertility and Development 30, no. 3 (2018): 533. http://dx.doi.org/10.1071/rd17157.

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Persistent mating-induced endometritis (PMIE) severely decreases fertility in horses. The aim of the present study was to evaluate differences between horses susceptible to PMIE and a control group in terms of the expression of selected immune response and effector genes, and the effects of oestrous cycle stage on this expression. Endometrial biopsies from 18 uterine samples of mares in the control group (eight in dioestrus, 10 in oestrus) and 16 PMIE-susceptible mares (four in dioestrus, 12 in oestrus) were analysed by quantitative real-time reverse transcription–polymerase chain reaction. Genes for pathogen recognition receptors Toll-like receptor 2 (TLR2) and NLR family CARD domain containing 5 (NLRC5), as well as tissue-specific inhibitor of metalloproteinase 1 (TIMP1), C-X-C motif chemokine ligand (CXCL) 9, CXCL10 and CXCL11 and uteroferrin were expressed at similar levels in the control group and in susceptible mares. Genes for C-C motif chemokine ligand 2 (CCL2) and the antimicrobial peptides secreted phospholipase A2 (sPLA2), lipocalin 2 and lactoferrin were all expressed at higher levels in susceptible compared with control mares. The expression of genes for the antimicrobial peptides equine β-defensin 1 (EBD1), lysozyme (LYZ) and secretory leukoprotease inhibitor (SLPI) was also higher in susceptible than control mares. The diagnostic sensitivity of assays for EBD1, LYZ and SLP1 gene expression to detect susceptibility to PMIE was estimated to be 100%, 94% and 100% respectively, with specificities of 83%, 78% and 78% respectively. When all three tests were positive, the specificity increased to 94%, with an overall sensitivity of 94%. The present study has yielded insights into pathophysiological changes in mares susceptible to PMIE and identified robust diagnostic markers (EBD1, LYZ and SLPI) for susceptibility to this disease.
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8

Yamaki, M., G. R. O. Menezes, A. L. C. Paiva, L. Barbosa, R. F. Silva, R. B. Teixeira, R. A. Torres, and P. S. Lopes. "Estudo de características de produção de matrizes de corte por meio da análise de componentes principais." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 61, no. 1 (February 2009): 227–31. http://dx.doi.org/10.1590/s0102-09352009000100032.

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Avaliou-se o descarte de variáveis de produção, em análises de componentes principais, de três linhagens de matrizes de corte do Programa de Melhoramento Genético da Universidade Federal de Viçosa, utilizando informações de 270 aves, sendo 90 de cada linhagem. As características analisadas foram dias para postura do primeiro ovo (DPPO), taxa de postura da 22ª a 56ª semana (TP), peso médio individual na 32ª (PMI1), na 40ª (PMI2), na 48ª (PMI3), na 56ª (PMI4) e na 64ª semana (PMI5) e peso médio do ovo, obtido pela média da pesagem de três ovos na 32ª (PMO1), na 40ª (PMO2), na 48ª (PMO3), na 56ª (PMO4) e na 64ª semana (PMO5). Dos 12 componentes principais, sete apresentaram variância menor do que 0,7 (autovalor menor do que 0,7), sugerindo-se sete variáveis para descarte. As variáveis descartadas foram aquelas que apresentaram maiores coeficientes, em valor absoluto, a partir do último componente principal. Observou-se correlação linear simples e significativa entre as variáveis descartadas e as não descartadas, que indica redundância de variáveis, razão do descarte. Recomendam-se as variáveis: DPPO, TP, PM14, PMO1 e PMO4 para o estudo de características da produção de matrizes de frango de corte por meio da análise de componentes principais.
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9

Borges, Lauren M., Ryan Holliday, Sean M. Barnes, Nazanin H. Bahraini, Adam Kinney, Jeri E. Forster, and Lisa A. Brenner. "A longitudinal analysis of the role of potentially morally injurious events on COVID-19-related psychosocial functioning among healthcare providers." PLOS ONE 16, no. 11 (November 12, 2021): e0260033. http://dx.doi.org/10.1371/journal.pone.0260033.

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Medical leaders have warned of the potential public health burden of a “parallel pandemic” faced by healthcare workers during the COVID-19 pandemic. These individuals may have experienced scenarios in which their moral code was violated resulting in potentially morally injurious events (PMIEs). In the present study, hierarchical linear modeling was utilized to examine the role of PMIEs on COVID-19 pandemic-related difficulties in psychosocial functioning among 211 healthcare providers (83% female, 89% White, and an average of 11.30 years in their healthcare profession [9.31]) over a 10-month span (May 2020 –March 2021). Reported exposure to PMIEs was associated with statistically significant poorer self-reported psychosocial functioning at baseline and over the course of 10-months of data collection. Within exploratory examinations of PMIE type, perceptions of transgressions by self or others (e.g., “I acted in ways that violated my own moral code or values”), but not perceived betrayal (e.g., “I feel betrayed by leaders who I once trusted”), was associated with poorer COVID-19 related psychosocial functioning (e.g., feeling connected to others, relationship with spouse or partner). Findings from this study speak to the importance of investing in intervention and prevention efforts to mitigate the consequences of exposure to PMIEs among healthcare providers. Interventions for healthcare providers targeting psychosocial functioning in the context of moral injury is an important area for future research.
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10

Metcalf, E. S. "The effect of Platelet-Rich Plasma (PRP) on intraluminal fluid and pregnancy rates in mares susceptible to Persistent Mating-Induced Endometritis (PMIE)." Journal of Equine Veterinary Science 34, no. 1 (January 2014): 128. http://dx.doi.org/10.1016/j.jevs.2013.10.087.

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11

Fang, Wenxia, Xiaoying Yu, Bin Wang, Hui Zhou, Haomiao Ouyang, Jia Ming, and Cheng Jin. "Characterization of the Aspergillus fumigatus phosphomannose isomerase Pmi1 and its impact on cell wall synthesis and morphogenesis." Microbiology 155, no. 10 (October 1, 2009): 3281–93. http://dx.doi.org/10.1099/mic.0.029975-0.

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Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P). The reaction catalysed by PMI is the first committed step in the synthesis of mannose-containing sugar chains and provides a link between glucose metabolism and mannosylation. In this study, the pmi1 gene was identified to encode PMI in the human fungal pathogen Aspergillus fumigatus. Characterization of A. fumigatus Pmi1 expressed in Escherichia coli revealed that this PMI mainly catalysed the conversion of Fru-6-P to Man-6-P and that its binding affinity for Man-6-P was similar to that of yeast PMIs, but different to those of PMIs from bacteria or animals. Loss of pmi1 was lethal unless Man was provided in the growth medium. However, a Δpmi1 mutant cell showed a significantly reduced growth rate at a high concentration of Man. Biochemical analysis revealed that both inadequate and replete Man led to an accumulation of intracellular Man-6-P and a reduction in the amount of α-glucan in the cell wall. Uncoupling of the link between energy production and glycosylation by deletion of the pmi1 gene led to phenotypes such as defects in cell wall integrity, abnormal morphology and reduced conidiation. Our results reveal that PMI activity is essential for viability and plays a central regulatory role in both cell wall synthesis and energy production in A. fumigatus.
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Korkmaz, Levent, Osman Bastug, Ahmet Ozdemir, Mahir Ceylan, Tamer Gunes, Mehmet Adnan Ozturk, and Sabriye Korkut. "Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?" American Journal of Perinatology 36, no. 11 (December 19, 2018): 1188–97. http://dx.doi.org/10.1055/s-0038-1676535.

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Objective Intraventricular hemorrhage (IVH) is an important problem in neonatal units not only in terms of its consequences but also its follow-up and the prediction of its emergence in newborns. In this study, we have compared platelet parameters such as platelet count (PC), mean platelet volume (MPV), and platelet mass index (PMI) in terms of IHV in very-low-birth-weight (VLBW) newborns. Thus, we have tried to determine platelet values to guide clinicians in both the prediction and follow-up of IVH. Study Design This is a retrospective, multicenter, and case-controlled study. In this study, 386 cases of VLBW newborns (below 1,500 g) and gestational age below 32 weeks, hospitalized and monitored between August 8, 2012, and April 7, 2018, were included. The platelet values of the cases on their 12th hour postpartum (PC1, MPV1, and PMI1) and the platelet values on days 5 to 7 (PC2, MPV2, and PMI2) were recorded in their study cards. A p-value of <0.05 was accepted as statistically significant. Results While there was no difference of PC1, MPV1, PMI1, PC2, or MPV2 values (p > 0.05), PMI2 values in the severe stage IVH group cases were found to be significantly lower compared with other platelet parameters (p < 0.05). Conclusion PMI2 values can provide clinicians with important knowledge that may aid them in recognizing important pathologies such as IVH.
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Oliveira, Cláudia Roberta Ribeiro de, Marcelo Vivas, Silvaldo Felipe da Silveira, Vivane Miriam Lanhellas Gonçalves, Rogério Figeuiredo Dhaer, Geraldo do Amaral Gravina, and Messias Gonzaga Pereira. "Potencial de progênies dioicas de mamoeiro para resistência à oídio." Summa Phytopathologica 44, no. 4 (December 2018): 350–54. http://dx.doi.org/10.1590/0100-5405/167210.

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RESUMO Variedades crioulas constituem fontes importantes de variabilidade genética a ser explorada pelos programas de melhoramento de plantas. No Brasil, o mamoeiro é cultivado comercialmente principalmente nos estados do Espírito Santo e Bahia, mas, domesticamente, é cultivado em todo extenso território brasileiro. Entretanto, estudos de exploração da variabilidade genética existente em variedades dióicas de mamoeiro são incipientes no País. O objetivo desse trabalho foi avaliar o potencial de 20 genótipos dióicos de mamoeiro para características relacionadas à resistência à oídio (Streptopodium caricae). Para tal, foi conduzido experimento em casa de vegetação delineado em blocos casualizados, com quatro repetições e uma planta por parcela. Avaliaram-se: incidência de folhas com sintoma de oídio e a severidade de oídio na quinta e sétima folhas. Os dados obtidos foram submetidos a análise de variância e teste de comparação de médias via método dos quadrados mínimos. Também foram estimados os componentes de variância e o valor genético de progênies para incidência e severidade de oídio via modelos mistos. Observou-se uma situação favorável para se praticar seleção visando à resistência a oídio, com herdabilidade variando de 51,57 à 67,82 e acurácia seletiva acima de 70%. As progênies PMI1, PMI6, PMI8, PMI11, PMI12 e PMI15 foram as que se destacaram por apresentarem potencial para redução tanto da incidência quanto da severidade de oídio em folha.
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Kühn, Daniela, Martin Ptok, and Michael Jungheim. "Hochauflösungsmanometrische Evaluation des velopharyngealen Verschlussdrucks beim Trompetenspiel." Laryngo-Rhino-Otologie 97, no. 05 (February 20, 2018): 321–26. http://dx.doi.org/10.1055/s-0043-124971.

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Zusammenfassung Hintergrund Bei etwa einem Drittel der Blasmusiker kommt es zu belastungsbedingten Insuffizienzen des velopharyngealen Abschlusses (VPA), d. h. der intraorale Druck übersteigt die durch den VPA gebildete Barriere. In dieser Studie sollte der Verschlussdruck im VPA beim Spielen einer Trompete gemessen und über prüft werden, welchen Einfluss eine 30-minütige Belastungssequenz auf die muskulären Aktivitäten im VPA hat. Material und Methoden Stichprobe: 6 gesunde Probanden. Aufgabe: Spielen des Tons h1 über 5 Sekunden mit 85 dB(A) und mit 100 dB(A). Methodik: Hochauflösungsmanometrie (HRM); Messzeitpunkte: t0: Messung ohne Einspielphase, t1 nach 30 min Trompetenspiel mit vorgegebenen Musikstücken. Variablen: mittlere Drücke (pmit), Minimal-(pmin)- sowie Maximaldrücke (pmax) zu t0 und t1 im VPA. Statistik: Prüfung auf Normalverteilung, t-test. Ergebnisse Alle gemessenen Drücke im VPA sanken von t0 zu t1 für produzierte 85 dB(A) Töne. Für 100 dB(A) Töne sanken nur die pmin. Die Drücke im VPA waren bei 100 dB(A) Tönen insgesamt höher als bei 85 dB(A) Tönen, signifikant war dieser Unterschied nur für pmin und pmax zu t0. Schlussfolgerung Lauter gespielte Töne erfordern eine stärkere muskuläre Kontraktion im VPA. Der niedrigere Verschlussdruck im VPA zum Zeitpunkt t1 kann Folge einer physiologischen muskulären Adaptation an das für den VPA notwendige Druckniveau oder bereits Zeichen einer muskulären Ermüdung sein. Dies ist möglicherweise für den Einsatz der HRM zur Beurteilung der Berufsfähigkeit von Blasinstrumentalisten von Bedeutung. Wie schon für die Phonation beschrieben, ließ sich auch hier mit einem dreiphasigen Modell, bestehend aus Initiation, stabiler Phase und Terminierung, der VPA Druckverlauf beschreiben.
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Zhu, Yunqing, Wenfang Zeng, Xiaobei Wang, Lei Pan, Liang Niu, Zhenhua Lu, Guochao Cui, and Zhiqiang Wang. "Characterization and Transcript Profiling of PME and PMEI Gene Families during Peach Fruit Maturation." Journal of the American Society for Horticultural Science 142, no. 4 (July 2017): 246–59. http://dx.doi.org/10.21273/jashs04039-17.

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Pectins are synthesized and secreted to the cell wall as highly methyl-esterified polymers and demethyl-esterified by pectin methylesterases (PMEs), which are regulated by pectin methylesterase inhibitors (PMEIs). PMEs and PMEIs are involved in pectin degradation during fruit softening; however, the roles of the PME and PMEI gene families during fruit softening remain unclear. Here, 71 PME and 30 PMEI genes were identified in the peach (Prunus persica) genome and shown to be unevenly distributed on all eight chromosomes. The 71 PME genes comprised 36 Type-1 PMEs and 35 Type-2 PMEs. Transcriptome analysis showed that 11 PME and 15 PMEI genes were expressed during fruit ripening in melting flesh (MF) and stony-hard (SH) peaches. Three PME and five PMEI genes were expressed at higher levels in MF than in SH fruit and exhibited softening-associated expression patterns. Upstream regulatory cis elements of these genes related to hormone response, especially naphthaleneacetic acid and ethylene, were investigated. One PME (Prupe.7G192800) and two PMEIs (Prupe.1G114500 and Prupe.2G279800), and their promoters were identified as potential targets for future studies on the biochemical metabolism and regulation of fruit ripening. The comprehensive data generated in this study will improve our understanding of the PME and PMEI gene families in peach. However, further detailed investigation is necessary to elucidate the biochemical function and regulation mechanism of the PME and PMEI genes during peach fruit ripening.
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Ullah, Safi, Haiong Li, Abdur Rauf, Shahid Ullah Khan, Sufyan Ullah Khan, Shucan Ge, Bin Wang, MaoYan Wang, and and Lin Meng. "The comparison of reaction of PMWE and PMSE to HF heating in terms of modulated characteristics." Earth and Planetary Physics 7, no. 2 (2023): 0. http://dx.doi.org/10.26464/epp2023029.

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17

Cao, Meijuan, Aijing Gao, Yuanyuan Liu, Yang Zhou, Zhicheng Sun, Yaling Li, Furui He, et al. "Theoretical Study on Electronic Structural Properties of Catalytically Reactive Metalloporphyrin Intermediates." Catalysts 10, no. 2 (February 13, 2020): 224. http://dx.doi.org/10.3390/catal10020224.

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Metalloporphyrins have attracted great attention in the potential application of biomimetic catalysis. Especially, they were widely investigated as green catalysts in the chemical oxidation of various hydrocarbons through the catalytic activation of molecular oxygen. The structural properties of active central metal ions were reported to play a decisive role in catalytic activity. However, those delicate structural changes are difficult to be experimentally captured or elucidated in detail. Herein, we explored the electronic structural properties of metalloporphyrins (metal porphyrin (PMII, PMIIICl)) and their corresponding catalytically active intermediates (metal(III)-peroxo(PMIII-O2), metal(III)-hydroperoxo(PMIII-OH), and metal(IV)-oxo(PMIV=O), (M=Fe, Mn, and Co)) through the density functional theory method. The ground states of these intermediates were determined based on the assessment of relative energy and the corresponding geometric structures of ground states also further confirmed the stability of energy. Furthermore, our analyses of Mulliken charges and frontier molecular orbitals revealed the potential catalytic behavior of reactive metalloporphyrin intermediates.
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Pinzon-Latorre, David, and Michael K. Deyholos. "Pectinmethylesterases (PME) and Pectinmethylesterase Inhibitors (PMEI) Enriched during Phloem Fiber Development in Flax (Linum usitatissimum)." PLoS ONE 9, no. 8 (August 14, 2014): e105386. http://dx.doi.org/10.1371/journal.pone.0105386.

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Paynel, Florence, Christelle Leroux, Ogier Surcouf, Annick Schaumann, Jérôme Pelloux, Azeddine Driouich, Jean Claude Mollet, Patrice Lerouge, Arnaud Lehner, and Alain Mareck. "Kiwi fruit PMEI inhibits PME activity, modulates root elongation and induces pollen tube burst in Arabidopsis thaliana." Plant Growth Regulation 74, no. 3 (March 28, 2014): 285–97. http://dx.doi.org/10.1007/s10725-014-9919-7.

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Liu, Bowen, Fangcheng Lv, Xiaozhou Fan, Yuxuan Li, and Bowen Jiang. "Molecular Dynamics Study of the Influence of Nano SiO2 on the Thermodynamic Properties of PMIA Composites." Polymers 14, no. 15 (August 1, 2022): 3134. http://dx.doi.org/10.3390/polym14153134.

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The poly-m-phenyleneisophthalamide (PMIA) is widely used in the electrical field due to its numerous favorable characteristics, but its poor thermal conductivity limits its application. In this study, PMIA was modified with nano-silica (SiO2) to improve its thermal and mechanical properties. Using iso-phthalic acid and m-phenylenediamine as monomers, the changes in the thermodynamic properties and microstructure parameters of SiO2-modified PMIA were analyzed using molecular dynamics before and after modification in the temperature range of 250~450 K. It was found that adding SiO2 improves the Young’s modulus and Shear modulus of PMIA, and the mechanical properties of PMIA, and SiO2/PMIA composites deteriorate with increasing temperature, but the mechanical properties of SiO2/PMIA composites are always better than those of pure PMIA in the temperature range of electrical equipment. Meanwhile, after doping SiO2 with the radius of 8 Å, the glass transition temperature of PMIA increases by 27.11 K, and its thermal conductivity increases from 0.249 W m−1 K−1 to 0.396 W m−1 K−1. When SiO2 is added to PMIA, the thermal expansion coefficient of PMIA will decrease in both glass and rubber states, and its thermal stability will improve. In terms of microstructure parameters, the free volume distribution of the SiO2/PMIA model is less easily dispersed than that of the PMIA model, indicating that the addition of SiO2 can improve the related properties of PMIA by hindering the movement of molecular chains.
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Röckel, Nina, Sebastian Wolf, Benedikt Kost, Thomas Rausch, and Steffen Greiner. "Elaborate spatial patterning of cell-wall PME and PMEI at the pollen tube tip involves PMEI endocytosis, and reflects the distribution of esterified and de-esterified pectins." Plant Journal 53, no. 1 (January 2008): 133–43. http://dx.doi.org/10.1111/j.1365-313x.2007.03325.x.

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Agusnawan, Rizal. "EKSISTENSI PMII DI BENGKULU (Analisis Sejarah dan Perkembangannya di Kota Bengkulu Antara Tahun 1990-2015)." Tsaqofah dan Tarikh: Jurnal Kebudayaan dan Sejarah Islam 3, no. 2 (December 23, 2018): 149. http://dx.doi.org/10.29300/ttjksi.v3i2.1560.

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Adapun tujuan penelitian ini Mengetahui Sejarah Organisasi Pergerakan Mahasiswa Islam Indonesia (PMII) di Bengkulu. Mengetahui Eksistensi (Pergerakan Mahasiswa Islam Indonesia) PMII terhadap Organisasi kemahasiswaan di Bengkulu dalam bidang sosial dan Keagamaan. Untuk mengungkapkan persoalan tersebut secara mendalam dan menyeluruh, peneliti menggunakan metode penelitian sejarah (historis) dengan cara melakukan observasi, wawancara dengan tokoh-tokoh pendiri, alumni, pengurus PMII kota Bengkulu dan tokoh PMII yang bisa memberikan informasi, Sejarah, Perkemabangan, eksistensi, kontribusi dan data mengenai PMII, kemudian data tersebut dianalisis dan dibahas untuk menjawab permasalahan tersebut. Dari penelitian ini ditemukan bahwa perta; perkembangan PMII di Kota Bengkulu Dalam mendidik anggota maupun kader, Pengurus Cabang PMII Kota Bengkulu menerapkan tiga bentuk pengkaderan, yakni formal, informal, non formal. Pengkaderan formal adalah pendidikan di PMII yang berjenjang dan terstruktur dengan jelas. Kedua; Kontribusi Pergerakan Mahasiswa Islam Indonesia (PMII) Kota Bengkulu terhadap aktivitas sosial kegamaan di Kota Bengkulu yakni dalam hal: Safari Ramadhan, Kerja Bakti Sosial bersama Warga, Peringatan Hari Besar Islam, Yasinan, Aksi Pengurus Cabang PMII Kota Bengkulu.
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Agbada, Andrew O., and Ekakitie-Emonena Sunny. "Empirical Analysis of Primary Mortgage Institutions Fundamentals and Gross Domestic Product Increase in Nigeria." Applied Finance and Accounting 2, no. 1 (December 17, 2015): 89. http://dx.doi.org/10.11114/afa.v2i1.1257.

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This study seeks to empirically analyze Primary Mortgage Institutions (PMIs) Fundamentals and Gross Domestic Product Increase; in other words, economic growth in Nigeria. The (PMIs) fundamentals in the new PMIs guidelines include Mortgage finance, Investments and Deposits taking. Thus, PMIs Loans, PMIs Investments and PMIs Deposits are adopted as the explanatory variables and served as proxies for PMIs fundamentals to explain Gross Domestic Products (GDP). Data used for empirical estimation were sourced from CBN statistical Bulletin, 2011 and 2013 and analyzed using Multiple Regression technique parameters. The research findings were robust. The statistical parameters exhibited high coefficients and the F-statistics which indicates the overall significance of the model stood at 75.23. These results led us to reject the null hypothesis and accept the alternate hypothesis that there is a strong relationship between GDP and PMIs Loans, PMIs Investments and PMIs Deposits. However, the coefficients of the t-test parameters were low indicating that the impact of the explanatory variables on GDP was very minimal, meaning that their contributions to GDP were not relevant. Conclusively, the results indicate that while there is a significant relationship between GDP and PMIs variables, the impact of these variables on GDP was not significant during the period under review. Thus, we recommend that relevant policies with capacity to boost the activities of PMIs for maximum productivity should be enacted by government regulatory agencies in order to re-equip the housing finance market and increase the ratio of mortgage finance as a percentage of GDP.
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Dahl, Alv A., Cecilie Essholt Kiserud, Sophie D. Fosså, Jon Håvard Loge, Kristin Valborg Reinertsen, Ellen Ruud, and Hanne C. Lie. "A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)." Cancers 13, no. 22 (November 18, 2021): 5800. http://dx.doi.org/10.3390/cancers13225800.

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Background: A major depressive episode (MDE) is typically self-rated by screening forms identifying probable MDE (pMDE). This population-based cross-sectional questionnaire study examined the prevalence rates of pMDE identified by the PHQ-9 screener in long-term survivors of childhood and adolescence (CACSs) and young adult cancer (YACSs) and a normative sample (NORMs). Methods: Data from 488 CACSs, 1202 YACSs, and 1453 NORMs were analyzed, and pMDE was defined both by cut-off ≥10 on the total PHQ-9 score and by an algorithm. Results: The prevalence rates of pMDE among CACSs were 21.5%, 16.6% in YACSs, and 9.2% among NORMs using the cut-off definition. With the algorithm, the prevalence rates of pMDE were 8.0% among CACSs, 8.1% among YACSs, and 3.9% among NORMs. Independent of definition, CACSs and YACSs had significantly increased prevalence rates of pMDE compared to NORMs. Psychosocial factors and self-rated health were significantly associated with both definitions of pMDE in multivariable analyses, while survivor groups, cancer types, and adverse events were not. Conclusion: Since pMDE has negative health consequences and is amenable to treatment, healthcare providers should be attentive and screen for pMDE in young cancer survivors. For PHQ-9, the preferred type of definition of pMDE should be determined.
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Zhang, Jin-Hong, Dong-Ru Feng, Hong-Ling Ma, Bing Liu, Hong-Bin Wang, Heng Xie, Ruo-Da Li, and Jin-Fa Wang. "Antitumor Effects of Pinus massoniana Bark Extract in Murine Sarcoma S180 Both in Vitro and in Vivo." American Journal of Chinese Medicine 40, no. 04 (January 2012): 861–75. http://dx.doi.org/10.1142/s0192415x12500644.

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Pinus massoniana bark extract (PMBE) is a mixture of flavonoids, and showed a capability of inducing cell apoptosis; however, its properties have not yet been fully investigated. This paper evaluates the antitumor effects of PMBE in murine sarcoma S180 both in vitro and in vivo. In vitro, the growth inhibition of S180 cells was concentration dependent on PMBE as shown by the CCK-8 assay. The AO/EB staining and flow cytometry assay showed that PMBE induced S180 cell apoptosis. Cell cycle analysis revealed that the cells in the S phase were decreased by treatment with PMBE. In vivo, the treatment of 100, 200, and 300 mg/kg PMBE reduced the tumor weight and volume of S180-bearing NIH mice by 9%–67% and 13%–68%, respectively. Peripheral leukocyte count and lymphoproliferation were increased significantly after treatment with PMBE. Our results suggest that PMBE inhibits the tumor cell growth by inducing cell apoptosis and improving lymphoproliferation.
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Park, Kyung-Mo, Chul-Woo Im, Chang-Duk Kim, and Hyung-Seok Jeong. "The Development of Next Generation Smart PMIS System." Korean Journal of Construction Engineering and Management 14, no. 2 (March 31, 2013): 117–30. http://dx.doi.org/10.6106/kjcem.2013.14.2.117.

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Lho, Young Hwan. "A Study on Evaluation of Power Management IC." Journal of IKEEE 20, no. 3 (September 30, 2016): 260–64. http://dx.doi.org/10.7471/ikeee.2016.20.3.260.

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28

Wang, Kun-Ping, Chao Zhang, Shou-Guo Zhang, En-Dong Liu, Lan Dong, Xiang-Zhen Kong, Peng Cao, et al. "3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/959253.

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Nrf2 is the key transcription factor regulating the antioxidant response which is crucial for cytoprotection against extracellular stresses. Numerousin vivostudies indicate that Nrf2 plays a protective role in anti-inflammatory response. 3-(3-Pyridylmethylidene)-2-indolinone (PMID) is a synthesized derivative of 2-indolinone compounds. Our previous study suggested that PMID induces the activation of Nrf2/ARE pathway, then protecting against oxidative stress-mediated cell death. However, little is known regarding the anti-inflammatory properties of PMID in severe inflammatory phenotypes. In the present study we determined if PMID treatment protects mice from dextran sodium sulphate- (DSS-) induced colitis. The result suggests that treatment with PMID prior to colitis induction significantly reduced body weight loss, shortened colon length, and decreased disease activity index compared to control mice. Histopathological analysis of the colon revealed attenuated inflammation in PMID pretreated animals. The levels of inflammatory markers in colon tissue and serum were reduced associated with inhibition of NF-κB activation. The expression levels of Nrf2-dependent genes such as HO-1, NQO1, and Nrf2 were increased in PMID pretreated mice. However, PMID pretreatment did not prevent DSS-induced colitis in Nrf2 knockout mice. These data indicate that PMID pretreatment in mice confers protection against DSS-induced colitis in Nrf2-dependent manner, suggesting a potential role of PMID in anti-inflammatory response.
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Liu, Liqi, Lei Chen, Zuming Hu, Junrong Yu, Jing-Zhu, Jinliang Sun, and Musu Ren. "Fabrication of the Colored PMIA Fibers by Wet Spinning: Effect of Spinning Parameters on the Coagulation Process." Journal of Engineered Fibers and Fabrics 9, no. 1 (March 2014): 155892501400900. http://dx.doi.org/10.1177/155892501400900116.

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The poly (m-phenylene isophthalamide) (PMIA) fiber, which can be prepared by wet spinning, is a kind of aromatic polyamide fiber. The spinning parameters could influence the performance and structure of the colored PMIA fiber such as the diffusion coefficient and coagulation bath. In this study, the PMIA spinning solutions doped with Color Inde purple 120 were first commixed in a pressurizer and then spun into a coagulation bath under a pressure about 0.3 MPa. In the coagulation bath, the pure or dope-dyed PMIA fibers were prepared by wet spinning at 323 K, and then the as-spun fibers were extracted by an ultrasonic oscillation method. The effects of jet stretch ratio, temperature, and concentration of the coagulation bath on the ratio of diffusion coefficient of solvent to coagulator were analyzed during the spinning process of dope-dyed PMIA fibers. The properties and structures of the colored PMIA fibers were characterized by SEM. Finally the most optimized spinning technology of the dope-dyed PMIA fiber was obtained and the dope-dyed PMIA fibers were successfully fabricated through wet spinning.
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30

Navarrete, F., F. Saravia, G. Cisterna, F. Rojas, L. Rodríguez-Alvarez, D. Rojas, and F. Castro. "210 Horse allogeneic mesenchymal stem cells perform homing and ameliorate endometrial inflammation after induced endometritis of mares." Reproduction, Fertility and Development 32, no. 2 (2020): 233. http://dx.doi.org/10.1071/rdv32n2ab210.

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Post-mating induced endometritis (PMIE) is an acute inflammatory response of the endometrium to spermatozoa, linked to an incapability of some mares to drain out the fluids associated with inflammation. This is of pivotal importance for reproductive success in mares. Mesenchymal stem cells (MSCs) are potential candidates for anti-inflammatory uterine therapies. Here, we aimed to study inflammatory markers in the endometrium of healthy mares and of those with induced endometritis, before and after intrauterine inoculation of MSCs, and to characterise their homing potential invivo in an induced endometritis horse model. Nine mares during their ovulatory season were selected after gynaecologic examination (absence of free liquid in the uterus, no polymorphonuclear leucocytes (PMNs) at cytology, negative bacteriology, and grade I in Kenney's scale on uterine biopsies). Mares were infused in the uterine body with 2mL of 500×106 spermmL−1 previously killed by repeated frozen-thawing cycles. At 3h, uteri were flushed with 250mL of sterile saline and the inflammatory response was monitored in the lavages and biopsies. Parameters measured included cytology, protein expression of inflammatory markers (supernatant) after lavage centrifugation (800×g, 10min), ELISA, and immunostaining for interleukin (IL)-6 and tumor necrosis factor alpha (TNFα). The mares were divided into three groups (3 mares each). Then, 24h after dead sperm challenge, group 1 received intrauterine infusion of 2×107 adipose MSC in 0.9% sterile saline; group 2, received the same amount of endometrial MSCs in the same vehicle; and group 3 received only saline. The volume of infusion in the uterine body was 20mL for all groups. Cells (passage 4) were previously labelled with 10μM Vybrant CFDA SE Cell Tracer Kit (ThermoFisher Scientific). After 48h, the same lavages, biopsies, and measurements as described above were performed. Additional biopsies were taken at Days 10 and 30 after intrauterine infusions. Biopsies were split in two, one for confocal microscopy and the other for quantitative PCR. Endometritis was induced in all mares, as judged by cytology and expression of protein markers of inflammation. After 48h, reduction in IL-6 and TNFα was detected by immunostaining of biopsies and confirmed by ELISA in the lavages, as well as by PCR. Homing was detected in all mares infused with MSC and it persisted at Days 10 and 30 after infusion. No homing was found in the control mares. As a result of these experiments, we conclude that inoculation of MSCs significantly reduced inflammation independently of the origin of the cells (adipose or endometrial). Both types of cells were nested in the endometrium at low quantities, although the number of cells actually detected at fixed time points was not quantified. Overall, we can propose that, given the number of homed cells detected and the marked decrease in inflammatory markers after inoculation of cells, MSCs exert their anti-inflammatory function preferentially by a paracrine mechanism and not necessarily by nesting and proliferation, although both events occur. Funding for this study was provided by Fondecyt 1150757.
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Wu, Shao Gui, Ya Ru Fan, and Jun Zhou. "Research Progress on Preparation Methods of PMIA Fiber." Advanced Materials Research 463-464 (February 2012): 769–72. http://dx.doi.org/10.4028/www.scientific.net/amr.463-464.769.

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PMIA is a functional fiber with superior heat-resistance, flame resistance, high temperature dimensional stability and electrical insulation. In PMIA crystal structure, there exist hydrogen bonds between two planes in the crystal and they are arranged in grid. The strong interactions between hydrogen bonds result in a very stable chemical structure of PMIA. Owing to lower internal rotation potential energy than PPTA, PMIA molecular chains are flexible structures and its elastic modulus is in the same level as other flexible macromolecules. In this paper, the structure character of molecular chain and performance of PMIA have been introduced. Additionally, the common used polymerization techniques for PMIA have been described in detail. These synthesis techniques include low-temperature solution polymerization, interfacial polymerization and emulsion polymerization.
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Andraos, John. "Relationships between step and cumulative PMI and E-factors: implications on estimating material efficiency with respect to charting synthesis optimization strategies." Green Processing and Synthesis 8, no. 1 (January 28, 2019): 324–36. http://dx.doi.org/10.1515/gps-2018-0131.

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Abstract This report describes mathematical relationships between step and cumulative process mass intensities (PMIs) for synthesis plans, and analogous parameters applied to E-factors. It is shown that both step E-factors and step PMIs are not additive for synthesis plans. It is also shown that a recursive calculation of cumulative PMIs from step PMIs is a rapid method of determining overall PMIs for synthesis plans, though cumulative PMIs are not sufficiently informative as step PMIs or step E-factors to identify bottlenecks in synthesis plans. Illustrations on the use of these metrics to track the material efficiency of published synthesis plans for the pharmaceutical, apixaban, are given as a template example. Advantages and disadvantages of each metric are discussed. A general algorithm to select the most promising candidate synthesis plans considered at the design stage for a given molecular target that most likely satisfy “green” material efficiency criteria is also presented.
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Izadfar, Hamid Reza, and Hamid Naseri. "Dynamic and steady state modeling of permanent magnet induction machine." COMPEL - The international journal for computation and mathematics in electrical and electronic engineering 37, no. 1 (January 2, 2018): 465–83. http://dx.doi.org/10.1108/compel-03-2017-0136.

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Purpose Modeling electric machines is one of the powerful approaches for analyzing their performance. A dynamic model and a steady-state model are introduced for each electric machine. Permanent magnet induction machine (PMIM) is a dual-rotor electric machine, which has various advantages such as high-power factor and low magnetizing current. Studying PMIM and its modeling might be valuable. The purpose of this paper is to introduce a simple and accurate method for dynamic and steady-state modeling of PMIM. Design/methodology/approach In this paper, arbitrary dqo reference frame is used to model PMIM. First, three-phase dynamic equations of stator and rotors are introduced. Then, they are transferred to an arbitrary reference frame. The voltage and magnetic flux equations aligned at dqo axes are obtained. These equations give the dynamic model. To investigate the results, PMIM simulation is performed according to obtained dynamic equations. Simulation results verify the analytic calculations. Findings In this paper, dynamic equations of PMIM are obtained. These equations are used to determine dynamic equivalent circuits of PMIM. Steady-state equations and one phase equivalent circuit of the PMIM using phasor relations are also extracted. Originality/value PMIM equations along dqo axes and their dynamic and steady-state equivalent circuits are determined. These equations and the equivalent circuits can be transformed to different reference frames and analyzed easily.
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Kawasaki, Yosuke, Atsushi Seichi, Liuzhe Zhang, Shoichiro Tani, and Atsushi Kimura. "Dynamic Changes of Cauda Equina Motion Before and After Decompressive Laminectomy for Lumbar Spinal Stenosis With Redundant Nerve Roots: Cauda Equina Activation Sign." Global Spine Journal 9, no. 6 (February 13, 2019): 619–23. http://dx.doi.org/10.1177/2192568218821344.

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Study Design: Cross-sectional observational study (consecutive case series). Objectives: The aim of this study was to define a criterion for achieving successful decompression of lumbar spinal stenosis (LSS) using intraoperative ultrasonography (IOUS) and to investigate the pathogenesis of redundant nerve roots (RNRs) based on the ultrasonographic findings. Methods: A total of 100 LSS patients (71 males, 29 females, mean age, 71 ± 8 years) with RNRs were enrolled as subjects in this study. IOUS was performed to evaluate pulsatile motion of the cauda equina (PMCE) just before and after decompressive laminectomy. To determine the decompression status of the cauda equina, the ultrasonographic findings were classified into 3 types on the basis of the presence or absence of PMCE: type 1, predecompression PMCE (−) to postdecompression PMCE (+); type 2, pre- and postdecompression PMCE (+); and type 3, pre- and postdecompression PMCE (−). The pathogenesis of RNRs was also investigated based on the ultrasonographic findings. Results: Around the stenosis, PMCE was almost always absent before decompression and appeared after decompression (type 1 in 94 patients, type 2 in 6, type 3 in 0). IOUS showed that, before decompression, the cauda equina was held at the stenosis and could not pulsate beyond the stenotic site, and after decompression, PMCE recovered in the craniocaudal direction, leading to the resolution of RNRs. Conclusions: The emergence of PMCE can be a sign of successful decompression for LSS. Ultrasonographic findings support the notion that disturbance of PMCE around the stenosis is a basic component of the pathogenesis of RNRs.
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Yang, Kailu, Xibo Liu, Xinya Wang, Tianxu Hao, Wei Zhang, and Mingxing Chen. "ZIF-8 modified poly (m-phenylene isophthalamide) (PMIA) hybrid membrane for dye wastewater treatment." Journal of Industrial Textiles 52 (August 2022): 152808372211392. http://dx.doi.org/10.1177/15280837221139235.

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The separation of dye/salt through the separation membranes is a great significance for the treatment of dye wastewater. In this study, a novel PMIA hybrid membrane was fabricated via nonsolvent induce phase separation (NIPS) method, in which porous zinc imidazolate framework-8 (ZIF-8) was utilized as a filler. The effect of ZIF-8 content on the structure and performance of PMIA/ZIF-8 membrane was investigated. The results showed that the structure and performance of the PMIA/ZIF-8 membrane could be controlled by changing the content of ZIF-8. The proper content of ZIF-8 was 0.45 wt% in this study. To further enhance the water flux of PMIA/ZIF-8 membrane, the concept of creating nanovoids within the ZIF-8 nanoparticle via wet-chemical etching method was explored in this study. The additional pore of ZIF-8 nanoparticles after wet-chemical etched endows PMIA/ZIF-8 membrane with additional pathways for water molecules. Hence, the PMIA/ZIF-8 membrane after wet-chemical etching showed higher separation performance for dye wastewater. The optimized PMIA/ZIF-8 membrane showed a water permeance of 104.7 L·m−2·h−1 and Congo red rejection of 98% at 0.1 MPa. The water permeance was about 1.5 times than that of the pristine PMIA/ZIF-8 membrane while the Congo red rejection was well maintained. Moreover, the PMIA/ZIF-8 membrane showed good thermal stability during the filtration process. These results indicated that PMIA/ZIF-8 membrane has potential application in dye wastewater treatment.
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Cao, H., W. Yu, X. Li, J. Wang, S. Gao, N. E. Holton, S. Eliason, T. Sharp, and B. A. Amendt. "A new plasmid-based microRNA inhibitor system that inhibits microRNA families in transgenic mice and cells: a potential new therapeutic reagent." Gene Therapy 23, no. 6 (March 2, 2016): 527–42. http://dx.doi.org/10.1038/gt.2016.22.

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Abstract Current tools for the inhibition of microRNA (miR) function are limited to modified antisense oligonucleotides, sponges and decoy RNA molecules and none have been used to understand miR function during development. CRISPR/Cas-mediated deletion of miR sequences within the genome requires multiple chromosomal deletions to remove all functional miR family members because of duplications. Here, we report a novel plasmid-based miR inhibitor system (PMIS) that expresses a new RNA molecule, which inhibits miR family members in cells and mice. The PMIS engineered RNA optimal secondary structure, flanking sequences and specific antisense miR oligonucleotide sequence bind the miR in a stable complex to inhibit miR activity. In cells, one PMIS can effectively inhibit miR family members that share the same seed sequence. The PMIS shows no off-target effects or toxicity and is highly specific for miRs sharing identical seed sequences. Transgenic mice expressing both PMIS-miR-17-18 and PMIS-miR-19-92 show similar phenotypes of miR-17-92-knockout mice. Interestingly, mice only expressing PMIS-miR-17-18 have developmental defects distinct from mice only expressing PMIS-miR-19-92 demonstrating usefulness of the PMIS system to dissect different functions of miRs within clusters. Different PMIS miR inhibitors can be linked together to knock down multiple miRs expressed from different chromosomes. Inhibition of the miR-17-92, miR-106a-363 and miR-106b-25 clusters reveals new mechanisms and developmental defects for these miRs. We report a new tool to dissect the role of miRs in development without genome editing, inhibit miR function in cells and as a potential new therapeutic reagent.
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Ferguson, Jessica J. A., Christopher Oldmeadow, David Bentley, and Manohar L. Garg. "Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating Pinus massoniana Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial." Antioxidants 11, no. 8 (August 11, 2022): 1560. http://dx.doi.org/10.3390/antiox11081560.

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Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (−1.19 nmol/mL, 95%CI −1.62, −0.75, p < 0.001) and 12 weeks (−1.35 nmol/mL, 95%CI −1.74, −0.96, p < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (p < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (−0.25 g/L, 95%CI −0.39, −0.11; p < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; p < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases.
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Nozaki, Isao, Shinji Hato, Hiroyuki Takahata, Shinichirou Hori, Toshihiko Matsumoto, Tomohiro Nishina, and Akira Kurita. "A Resected Case of Primary Malignant Melanoma of the Esophagus—Early Detection of Recurrence by FDG-PET/CT." International Surgery 102, no. 9-10 (September 1, 2018): 459–64. http://dx.doi.org/10.9738/intsurg-d-14-00302.1.

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Primary malignant melanoma of the esophagus (PMME) is a rare, aggressive, therapy-resistant malignant tumor arising from esophageal mucosal melanocytes. It has been reported that fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) has a clinical impact on PMME diagnosis; however, it remains unclear whether postoperative surveillance using FDG-PET/CT is useful for PMME patients. In this case study, FDG-PET/CT detected the recurrent tumors in their early stage after a curative resection of PMME. We report on a case of a 67-year-old Japanese male admitted to our hospital for the evaluation of polypoid tumors of the esophagogastric junction, which were diagnosed as PMME. He was treated with a curative resection by esophagectomy and 6 cycles of adjuvant chemotherapy of DAV (dacarbazine, nimustine, and vincristine). However, the PMME recurred 26 months after the surgery when surveillance FDG-PET/CT detected the recurrent tumors in their early stage. FDG-PET/CT may be useful to detect recurrence in the postoperative surveillance phase for PMME patients.
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Wang, Maojun, Daojun Yuan, Wenhui Gao, Yang Li, Jiafu Tan, and Xianlong Zhang. "A Comparative Genome Analysis of PME and PMEI Families Reveals the Evolution of Pectin Metabolism in Plant Cell Walls." PLoS ONE 8, no. 8 (August 12, 2013): e72082. http://dx.doi.org/10.1371/journal.pone.0072082.

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Zhang, Qi, Tingting Pu, Yiru Wang, Yue Bai, Yujing Suo, and Jianmin Fu. "Genome-Wide Identification and Expression Analysis of the PME and PMEI Gene Families in Diospyros kaki: A Bioinformatics Study." Horticulturae 8, no. 12 (December 7, 2022): 1159. http://dx.doi.org/10.3390/horticulturae8121159.

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Pectins are major components of cell walls in plants. Pectin methylesterases (PMEs) and pectin methylesterase inhibitors (PMEIs) play crucial roles in pectin synthesis and metabolism. Overall, 28 putative DkPMEs and 29 putative DkPMEIs were identified from the D. kaki genome. According to phylogenetic analysis, DkPME/DkPMEI proteins can be classified into four and five clades, respectively. Motif and gene structure analysis showed that DkPME/DkPMEI are highly conserved in the same clades, which indicates that the function of these DkPME/DkPMEI were similar. Besides, DkPME/DkPMEI genes were distributed unevenly on their corresponding chromosomes. Synteny analysis showed that PME or PMEI gene usually matched with more than one DkPME/DkPMEI in D. oleifera, D. lotus, and A. thaliana, implying that the function of these genes in D. kaki may be diverse. Expression analysis showed that DkPME/DkPMEI from the same clade exhibited diverse expression patterns, indicating that these genes might have diverse functions. Functional protein–protein interaction network analysis showed that DkPMEI21 and DkPMEI15 were core nodes and were, respectively, positive and negative regulators for carbohydrate metabolism, stress responses, and sugar signaling. This study provides a theoretical basis for the functional characteristics, evolutionary relationship, and role of these gene families in developing persimmon fruit.
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41

Aqil, Hasan Labiqul, and Moh Aris Munandar. "Kaderisasi PMII Cabang Kota Semarang dalam Meningkatkan Kapasitas Kepemimpinan Anggota." Unnes Political Science Journal 4, no. 1 (January 2, 2020): 1–6. http://dx.doi.org/10.15294/upsj.v4i1.42378.

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Kaderisasi merupakan hal yang penting dalam sebuah organisasi, terutama organisasi pengaderan seperti PMII, dengan adanya kaderisasi menandakan adanya kelanjutan dari sebuah organisasi. Kaderisasi yang merupakan proses kegiatan penyiapan, membina, serta mengasuh sumber daya manusia secara terdidik dan berkesinambungan, harapannya mampu menghasilkan kader yang dapat memimpin dengan baik untuk mengganti pemimpin yang lama serta membangun peran dan fungsi organisasi lebih baik. Rumusan masalah dalam penelitian ini adalah: (1) Bagaimana kaderisasi PMII Cabang Kota Semarang dilaksanakan? (2) Bagaimana pelaksanaan kegiatan pelatihan kepemimpinan dalam kaderisasi PMII ?. Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif. Teknik pengumpulan data menggunakan teknik wawancara, observasi, dan dokumentasi. Hasil penelitian yang diperoleh menunjukan bahwa kaderisasi organisasi PMII berperan dalam meningkatkan kapasitas kepemimpinan anggota melalui program kaderisasi formal, nonformal, dan informal. Tahapan kaderisasi PMII terdiri dari tahap rekrutmen, pendidikan atau pelatihan, dan pengabdian. Dalam tahap pendidikan atau pelatihan khususnya bentuk kaderisasi formal mengenal jenjang kaderisasi. Diawali dengan MAPABA yang dilaksanakan di tingkat Rayon atau Fakultas, kemudian PKD yang dilaksanakan di tingkat Komisariat atau Universitas, dan PKL yang dilaksanakan langsung oleh Pengurus Cabang PMII Kota Semarang. Adapun metode yang sering digunakan oleh PMII Cabang Kota Semarang dalam melaksanakan kaderisasinya adalah diskusi dan juga distribusi kader. Regeneration is important in organizations, especially cadre organizations such as PMII, with the presence of cadre signification of the existence of an organization. The regeneration which is the process of preparing, developing and caring for educated and sustainable human resources, hopes to be able to produce cadres who can lead well to replace the old leaders and develop the role and function of the organization better.The purpose of this research is to find out:(1) How is the regeneration of PMII in the branch of Semarang City carried out? (2) How is the implementation of leadership training activities in PMII regeneration?. The research method used in this research is qualitative. Data collection techniques using interview techniques, observation, and documentation. The results obtained indicate that PMII organizational regeneration plays a role in improving student leadership capacity through formal, non-formal and informal regeneration programs. The stages of PMII regeneration consist of the stages of recruitment, education or training, and service. In the education or training stage, especially in the form of formal regeneration, recognize the level of regeneration. It starts with MAPABA which is carried out at the Rayon or Faculty level, then PKD is carried out at the Commissariat or University level, and PKL is carried out directly by the PMII Semarang Branch Management. The method that is often used by PMII Semarang City Branch in carrying out its regeneration is discussion and also the distribution of cadres.
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42

Li, Jingjing, Shi Yan, Wenyan Guan, Xiao Xiao, Bing Liu, Changxi Wang, Zicheng Yu, Yuanyuan Ma, and Nan Wu. "Genomic analysis of primary malignant melanoma of the esophagus." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e21515-e21515. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21515.

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e21515 Background: Primary malignant melanoma of the esophagus (PMME) is an exceedingly rare disease but behave more aggressively and have a poorer prognosis. No specific histopathological classification and therapy strategies have been established for this type of disease due to lack of both tumor biological and genetics perception to PMME. Methods: We performed whole exome sequencing on 29 dissections including 23 primary tumors and 6 metastatic lymph nodes from 18 PMME patients. The genetic characteristics including somatic mutations and copy number variation (CNV) of PMME were compared to 398 skin cutaneous melanoma (SKCM), 67 mucosal melanoma (MM) and 79 uveal melanoma (UVM). Using multi-region sequencing, we reconstructed the phylogenetic structure and inferred the evolutionary mode. Results: We found that PMME/MM have similar genomic patterns to SKCM but distinct from UVM. Frequently mutated driver genes such as MUC16, BRAF, NRAS, NF1, KMT2C, POLE, PTPRT, RANBP2 appeared in both SKCM and PMME/MM cohorts. Of note, pathway enrichment analysis using identified driver genes revealed that melanoma pathway and MAPK signaling pathway were among the top affected pathways in MM/PMME as well as in SKCM. UVR-associated single base substitution signature 7 (SBS7) was not a dominant signature (median: 0.17, range:0̃0.79) in PMME/MM but 99 percent (89/90) of them do have it. An overall concordant trend in genome instability was found between PMME and SKCM. Significant CNV events at arm level showed the similar changes in PMME and SKCM, including amplification regions of 1q, 6p, 7p, 8q, 15q, 20p and deletion of 10p, 10q, 11p. CDKN2A loss appeared as a shared focal event by PMME and SKCM. To elucidate the evolution trajectory of spatially separated samples, we also performed multi-region sequencing, and the phylogenetic analysis suggested that whole genome doubling (WGD) was an early and clonal event, which preceded the majority of somatic mutations and CNV. Most driver genes such as NF1, RANBP2 and MUC16 mutated after WGD except TP53. Above findings suggested that WGD might be capable of promoting ongoing genome instability and shaping the evolution in PMME. Moreover, parallel evolution of RANBP2 was recurrently observed indicating the existence of constraints and selection. Conclusions: Our data showed that PMME/MM exhibited genetic features very similar to SKCM so it might not be excluded from treatments currently used for common SKCM.
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43

Priatmoko, Hadi, Yuyun Yunengsih, and Sali Setiatin. "Analisa Kebutuhan Tenaga Rekam Medis Berdasarkan Beban Kerja dengan Metode ABK-Kes di Bagian Case Mix Rumah Sakit X Palembang Tahun 2021." Jurnal Health Sains 2, no. 8 (August 24, 2021): 1008–13. http://dx.doi.org/10.46799/jhs.v2i8.249.

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The role of coders is important for hospitals. The available coders to achieve harmony in a job. As a process to get the number of hours of work needed to complete the workload in a certain time an analysis of the workload is needed.This study was conducted to calculate the number of PMIK personnel needed at Hospital X Palembang according to workload analysis. This was a descriptive study with qualitative approach. Data collection is using observation and interview to the Coder employee at X Hospital Palembang.The education qualification of Coder employees at X Hospital Palembang are 4 (four) PMIK with Associate’s Degree of Medical Records. Human Resources SDM of SIK’s calculation (Case Mix) uses the medical workload analysis (ABK-Kes) method are 4 (four) PMIK and at X Hospital Palembang there are 4 (four) PMIK, so that the amount is still relatively safe to complete tasks according to the existing workload. The conclusion of this study is the number of PMIK coders in Hospital X Palembang there are 4 (four) PMIK coders. Calculation of HRK needs in the SIK (Case Mix) section using the Health Workload Analysis (ABK-Kes) method of 4 (four) PMIK and in X Palembang Hospital there are 4 (four) PMIK so that the number of officers is still relatively safe to complete tasks according to existing workloads.
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44

Wenzel, Michael, Alexander Leunig, Shuting Han, Darcy S. Peterka, and Rafael Yuste. "Prolonged anesthesia alters brain synaptic architecture." Proceedings of the National Academy of Sciences 118, no. 7 (February 10, 2021): e2023676118. http://dx.doi.org/10.1073/pnas.2023676118.

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Prolonged medically induced coma (pMIC) is carried out routinely in intensive care medicine. pMIC leads to cognitive impairment, yet the underlying neuromorphological correlates are still unknown, as no direct studies of MIC exceeding ∼6 h on neural circuits exist. Here, we establish pMIC (up to 24 h) in adolescent and mature mice, and combine longitudinal two-photon imaging of cortical synapses with repeated behavioral object recognition assessments. We find that pMIC affects object recognition, and that it is associated with enhanced synaptic turnover, generated by enhanced synapse formation during pMIC, while the postanesthetic period is dominated by synaptic loss. Our results demonstrate major side effects of prolonged anesthesia on neural circuit structure.
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45

Zhao, Hui Fang, and Mei Yun Zhang. "Surface Modification of Poly (M-Phenylene isophthalamide) Fibers and its Effect on the Mechanical Properties of Aramid Sheets." Advanced Materials Research 314-316 (August 2011): 205–8. http://dx.doi.org/10.4028/www.scientific.net/amr.314-316.205.

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In order to improve the bonding properties between poly (m-phenylene isophthalamide) (PMIA) fibers and PMIA-pulp and to improve the mechanical strength of aramid sheets, PMIA fibers have been treated with various chemical modifying agents. The surface morphology of the treated fibers has been analyzed and the mechanical properties of aramid sheets made from the treated PMIA fibers and PMIA-pulp have been investigated. The results show that silane coupling agent modification, phosphoric acid modification and nitrification/reduction modification of PMIA fibers are all helpful for improving the tensile strength and tear strength of aramid sheets, however, they have different effect on the mechanical strength of aramid sheets, and the concentration of chemical modifying agents also has considerable influence on the surface properties of aramid fibers and the mechanical properites of aramid sheets. Aramid handsheets made from PMIA fibers treated with 20% phosphoric acid have the highest mechanical strength, and the tensile strength and tear strength of them are 23.4% and 31.6% higher than that of aramid handsheets made from untreated fibers, respectively, because the treated fiber surface has more oxygenous functional groups and is more rough than the untreated fiber surface.
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46

Kim, Myeong-Jin, Tae-Hwan Jung, Gyu-Tae Noh, and Kyo-Jin Koo. "Prototype Structure of integrated Document Forms for Construction PMIS based on Analysis." Korean Journal of Construction Engineering and Management 12, no. 5 (September 30, 2011): 3–11. http://dx.doi.org/10.6106/kjcem.2011.12.5.3.

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47

Na, Kwang-Tae, and Byeung-Hee Kang. "The Establishment of an Activity-Based EVM - PMIS Integration Model." Journal of the Korean Institute of Building Construction 10, no. 1 (February 20, 2010): 199–212. http://dx.doi.org/10.5345/jkic.2010.10.1.199.

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48

Wang, Yi, Jun Yan, Yunlin Chen, and Qiuhong Cui. "The effects of Tb doping on the negative and positive magnetocaloric effects of Mn3Ga1−xTbxC (0.02 ≤ x ≤ 0.05)." Journal of Applied Physics 132, no. 13 (October 7, 2022): 135108. http://dx.doi.org/10.1063/5.0111987.

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Generally, researchers focus on the great negative magnetocaloric effect (NMCE) rather than the positive magnetocaloric effect (PMCE) in Mn3GaC. Here, we prepared Mn3Ga1−xTbxC composites with a partial substitution of Ga by Tb. Tb doping expands the canted-ferromagnetic phase (CFM) between the anti-ferromagnetic and ferromagnetic phase in Mn3Ga0.97Tb0.03C. The CFM phase can be as a boundary to separate the NMCE from PMCE. It is possible to combine the NMCE and PMCE for refrigeration. Compared with NMCE in Mn3GaC, NMCE–PMCE combination in Mn3Ga0.97Tb0.03C displays a much larger operating temperature range without loss of magnetic entropy changes. Therefore, the NMCE–PMCE combination is valuable for improving the operating temperature range of magnetocaloric effect materials. It also provides a new idea for refrigeration applications.
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49

Cheng, Yu He, Biao Zhang, Shang Jiang Dai, Han Lin Tong, and Li Xia Li. "Reusable and Efficient Polystryrene-Supported Acidic Ionic Liquid Catalyst for the Synthesis of n-Butyl Acetate." Advanced Materials Research 983 (June 2014): 20–25. http://dx.doi.org/10.4028/www.scientific.net/amr.983.20.

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A series of polystyrene-supported 1-(propyl-3-sulfonate)-3-methy-imidazolium hydrosulfate acidic ionic liquid (PS-[SO3H-PMIM][HSO4]) catalysts with different [SO3H-PMIM][HSO4] contents were prepared and tested for esterification of n-butyl alcohol with acetic acid. It was found that the reactivity of the catalyst increased with increasing [SO3H-PMIM][HSO4] content, and best yield of n-Butyl acetate of 98% was obtained using PS-[SO3H-PMIM][HSO4]1 within 1.5h. The catalytic activity of this catalyst decreased slightly after fifth using.
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50

Berzisa, Solvita. "Application of Project Management Information Systems in Efficiency Improvement of Quality Management System." Environment. Technology. Resources. Proceedings of the International Scientific and Practical Conference 3 (June 16, 2015): 17. http://dx.doi.org/10.17770/etr2015vol3.173.

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Project management information systems (PMIS) and quality management system (QMS) are two components in the project oriented organization that helps to achieve required quality of the project product. QMS define quality framework and PMIS helps to ensure quality framework requirement related to the projects. The objective of paper is to evaluate and demonstrate PMIS options for efficiency QMS development and maintenance. QMS requirements are identified according to ISO 9001:2008 standard and PMIS options of efficiency improvement are evaluated according to ISO 9004:2009 self-assessment tool.
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