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Journal articles on the topic 'PLMIC'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

N'Diaye, Elsa-Noah, and Eric J. Brown. "The ubiquitin-related protein PLIC-1 regulates heterotrimeric G protein function through association with Gβγ." Journal of Cell Biology 163, no. 5 (December 8, 2003): 1157–65. http://dx.doi.org/10.1083/jcb.200307155.

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PLIC-1, a newly described ubiquitin-related protein, inhibited both Jurkat migration toward SDF-1α and A431 wound healing, but the closely related PLIC-2 did not. PLIC-1 prevented the SDF-1α–induced activation of phospholipase C, decreased ligand-induced internalization of SDF-1α receptor CXCR4 and inhibited chemotaxis signaled by a transfected Gi-coupled receptor. However, PLIC-1 had no effect on Gs-mediated adenylyl cyclase activation, and inhibited only the Gβγ-dependent component of Gq-initiated increase in [Ca2+]i, which is consistent with selective inhibition of Gβγ function. PLIC-1 colocalized with G proteins in lamellae and pseudopods, and precipitated Gβγ in pull downs. Interaction with Gβγ did not require PLIC-1's ubiquitin-like or ubiquitin-associated domains, and proteasome inhibition had no effect on SDF-1α activation of phospholipase C, indicating that PLIC-1's inhibition of Gβγ did not result from effects on proteasome function. Thus, PLIC-1 inhibits Gi signaling by direct association with Gβγ; because it also interacts with CD47, a modulator of integrin function, it likely has a role integrating adhesion and signaling components of cell migration.

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N'Diaye, Elsa-Noah, Aylin C. Hanyaloglu, Kimberly K. Kajihara, Manojkumar A. Puthenveedu, Ping Wu, Mark von Zastrow, and Eric J. Brown. "The Ubiquitin-like Protein PLIC-2 Is a Negative Regulator of G Protein-coupled Receptor Endocytosis." Molecular Biology of the Cell 19, no. 3 (March 2008): 1252–60. http://dx.doi.org/10.1091/mbc.e07-08-0775.

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The activity of many signaling receptors is regulated by their endocytosis via clathrin-coated pits (CCPs). For G protein-coupled receptors (GPCRs), recruitment of the adaptor protein arrestin to activated receptors is thought to be sufficient to drive GPCR clustering in CCPs and subsequent endocytosis. We have identified an unprecedented role for the ubiquitin-like protein PLIC-2 as a negative regulator of GPCR endocytosis. Protein Linking IAP to Cytoskeleton (PLIC)-2 overexpression delayed ligand-induced endocytosis of two GPCRs: the V2 vasopressin receptor and β-2 adrenergic receptor, without affecting endocytosis of the transferrin or epidermal growth factor receptor. The closely related isoform PLIC-1 did not affect receptor endocytosis. PLIC-2 specifically inhibited GPCR concentration in CCPs, without affecting membrane recruitment of arrestin-3 to activated receptors or its cellular levels. Depletion of cellular PLIC-2 accelerated GPCR endocytosis, confirming its regulatory function at endogenous levels. The ubiquitin-like domain of PLIC-2, a ligand for ubiquitin-interacting motifs (UIMs), was required for endocytic inhibition. Interestingly, the UIM-containing endocytic adaptors epidermal growth factor receptor protein substrate 15 and Epsin exhibited preferential binding to PLIC-2 over PLIC-1. This differential interaction may underlie PLIC-2 specific effect on GPCR endocytosis. Identification of a negative regulator of GPCR clustering reveals a new function of ubiquitin-like proteins and highlights a cellular requirement for exquisite regulation of receptor dynamics.

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Zhang, Yujiao, Zengyou Li, Juan Gu, Yanke Zhang, Wei Wang, Hui Shen, Guojun Chen, and Xuefeng Wang. "Plic-1, a new target in repressing epileptic seizure by regulation of GABAAR function in patients and a rat model of epilepsy." Clinical Science 129, no. 12 (November 11, 2015): 1207–23. http://dx.doi.org/10.1042/cs20150202.

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Plic-1 regulates GABAAR expression at synaptic sites during epileptic seizure. Plic-1 prolongs the seizure latency and reduces the seizure severity in epileptic rats. Plic-1 affects the inhibitory function by changing the mIPSCs and evoked IPSCs of the phasic GABA-ergic synaptic current.

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Moshel, Yaron A., Robert E. Elliott, David J. Monoky, and Jeffrey H. Wisoff. "Role of diffusion tensor imaging in resection of thalamic juvenile pilocytic astrocytoma." Journal of Neurosurgery: Pediatrics 4, no. 6 (December 2009): 495–505. http://dx.doi.org/10.3171/2009.7.peds09128.

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Object The choice of surgical approach during resection of a thalamic juvenile pilocytic astrocytoma (JPA) is dictated by the location of the displaced normal thalamus and posterior limb of the internal capsule (PLIC). Diffusion tensor (DT) imaging and white matter tractography can identify the location of the PLIC in relation to the tumor and may be useful in planning the operative trajectory. Methods Diffusion tensor imaging was used to localize the PLIC on preoperative MR imaging in 6 children undergoing resection of thalamic JPAs. After review of the standard T2-weighted MR imaging sequences, the anticipated position of the PLIC was determined. This result was compared with the location of the PLIC determined by a blinded radiologist with the use of DT imaging. The utility of DT imaging in determining the surgical approach to a thalamic JPA, degree of resection, and neurological outcomes were all evaluated. Results Diffusion tensor imaging confirmed the expected location of the PLIC as approximated on conventional T2-weighted images in all 6 cases. In 1 patient in particular, unexpected medial deviation of the PLIC was identified, and this proved useful in tailoring the approach to a more lateral trajectory. Gross-total resection of all cystic and solid tumor components was confirmed on postoperative imaging in all cases. All patients experienced mild to moderate worsening of neurological status immediately following resection, but 4 of 6 patients were back to their preoperative baseline at 6-month follow-up. Conclusions Diffusion tensor imaging and white matter tractography successfully identified the white matter fibers emanating from the precentral gyrus within the PLIC in children with thalamic JPAs prior to surgery. Diffusion tensor imaging served as a valuable tool for stereotactic planning of operative approaches to thalamic JPAs. Localizing the position of the PLIC helped minimize potential neurological morbidity and facilitated gross-total resection.

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Schipper, Mirjam H., Korné Jellema, Diego Alvarez-Estevez, Johan Verbraecken, and Roselyne M. Rijsman. "Sleep-Related Leg Movements in Patients with Transient Ischemic Attack and Controls." European Neurology 79, no. 3-4 (2018): 171–76. http://dx.doi.org/10.1159/000487666.

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Background: Periodic leg movements during sleep (PLMS) have been associated with an increased risk for cardiovascular diseases and there is a high prevalence of PLMS found in patients with obstructive sleep apnea syndrome (OSAS). We evaluated patients with transient ischemic attack (TIA) for PLMS and respiratory related leg movements (RRLM), versus a control group without TIA. Methods: Twenty-five patients with TIA and 34 patients with no vascular diagnosis were referred for polysomnography. Diagnosis of PLMS was made if the periodic leg movement index (PLMI) was ≥5 and clinical significant as PLMI ≥15. Results: There was no significant difference in PLMI ≥5 and ≥15 between patients with and without TIA. In the absence of OSAS, 2 out of 5 TIA patients (40%) had a PLMI ≥15 compared to 1 of the 19 patients without TIA (5%; p = 0.037). There was no increase in RRLMs when OSAS was present. Conclusions: TIA patients did not have higher PLMI compared to controls, and in the presence of OSAS, there was no increase in RRLMs compared to patients without TIA. In selective patients, PLMS could be associated with cardiovascular diseases, since PLMS was clinically more often found in the TIA group without OSAS.

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Budhiraja, Rohit, Sogol Javaheri, Milena K. Pavlova, Lawrence J. Epstein, Olabimpe Omobomi, and Stuart F. Quan. "Prevalence and correlates of periodic limb movements in OSA and the effect of CPAP therapy." Neurology 94, no. 17 (December 27, 2019): e1820-e1827. http://dx.doi.org/10.1212/wnl.0000000000008844.

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ObjectiveWe sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized controlled trial.MethodsWe performed retrospective analyses of data from the Apnea Positive Pressure Long-term Efficacy Study, a prospective multicenter randomized controlled trial. A total of 1,105 persons with OSA enrolled in this study underwent a polysomnographic investigation at baseline, another one for CPAP titration, and another study 6 months after randomization to either active CPAP or sham CPAP.ResultsOf all participants, 19.7% had PLM index (PLMI) ≥10/hour, 14.8% had PLMI ≥15/hour, 12.1% had PLMI ≥20/hour, 9.3% had PLMI ≥25/hour, and 7.5% had PLMI ≥30/hour. The odds of having a PLMI ≥10 were higher in older participants (odds ratio [OR] 1.03, p < 0.001), men (OR 1.63. p = 0.007), those using antidepressants (OR 1.48. p = 0.048), and those with higher caffeine use (OR 1.01, p = 0.04). After controlling for OSA and depression, PLMS were associated with increased sleep latency, reduced sleep efficiency, and reduced total sleep time. No significant relationships were noted between PLMS frequency and subjective sleepiness (Epworth Sleepiness Scale score) or objective sleepiness (Maintenance of Wakefulness Test). There was no differential effect of CPAP in comparison to sham CPAP on PLMS after 6 months of therapy.ConclusionsPLMS are common in patients with OSA and are associated with a significant reduction in sleep quality over and above that conferred by OSA. Treatment with CPAP does not affect the severity of PLMS.

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Bailer, Janina, Stefan Feth, Felix Bretschneider, Sabine Rosenfeldt, Markus Drechsler, Volker Abetz, Holger Schmalz, and Andreas Greiner. "Synthesis and self-assembly of biobased poly(limonene carbonate)-block-poly(cyclohexene carbonate) diblock copolymers prepared by sequential ring-opening copolymerization." Green Chemistry 21, no. 9 (2019): 2266–72. http://dx.doi.org/10.1039/c9gc00250b.

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Karubiu, Wilson, Soumendranath Bhakat, Lara McGillewie, and Mahmoud E. S. Soliman. "Flap dynamics of plasmepsin proteases: insight into proposed parameters and molecular dynamics." Molecular BioSystems 11, no. 4 (2015): 1061–66. http://dx.doi.org/10.1039/c4mb00631c.

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9

Colpani, O., E. Tragni, M. Casula, E. Olmastroni, A. L. Catapano, and P. Magni. "Cardiometabolic profile in PLIC-MI and PLIC-CHIESA cohorts: Comparison of two different geographic settings." Atherosclerosis 315 (December 2020): e182-e183. http://dx.doi.org/10.1016/j.atherosclerosis.2020.10.568.

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Yang, Seung Hyeop, Joon Ki Kim, and Hong Bae Park. "Design of Robust and Non-Fragile Kalman Filter with Polytopic Uncertainties: PLMI Approach." Applied Mechanics and Materials 284-287 (January 2013): 2356–60. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.2356.

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In this paper, we describe the synthesis of robust and non-fragile Kalman filter design for a class of uncertain linear system with polytopic uncertainties and filter gain variations. The sufficient condition of filter existence, the design method of robust non-fragile filter, and the measure of non-fragility in filter are presented via LMIs(Linear Matrix Inequality) technique. And the obtained sufficient condition can be represented as PLMIs(Parameterized Linear Matrix Inequalities) that is, coefficients of LMIs are functions of a parameter confined to a compact set. Since PLMIs generate infinite LMIs, we use relaxation technique, find a finite solution for robust non-fragile filter, and show that the resulting filter guarantees the asymptotic stability with parameter uncertainties and filter fragility. Finally, a numerical example is shown to validate the proposed design method.

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Baragetti, Andrea, Alice Ossoli, Arianna Strazzella, Sara Simonelli, Ivano Baragetti, Liliana Grigore, Fabio Pellegatta, Alberico L. Catapano, Giuseppe Danilo Norata, and Laura Calabresi. "Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease." Journal of Clinical Medicine 9, no. 7 (July 18, 2020): 2289. http://dx.doi.org/10.3390/jcm9072289.

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Low high-density lipoprotein-cholesterol (HDL-c) is the most remarkable lipid trait both in mild-to-moderate chronic kidney disease (CKD) patients as well as in advanced renal disease stages, and we have previously shown that reduced lecithin:cholesterol acyltransferase (LCAT) concentration is a major determinant of the low HDL phenotype. In the present study, we test the hypothesis that reduced LCAT concentration in CKD contributes to the progression of renal damage. The study includes two cohorts of subjects selected from the PLIC study: a cohort of 164 patients with CKD (NefroPLIC cohort) and a cohort of 164 subjects selected from the PLIC participants with a basal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2 (PLIC cohort). When the NefroPLIC patients were categorized according to the LCAT concentration, patients in the 1st tertile showed the highest event rate at follow-up with an event hazard ratio significantly higher compared to the 3rd LCAT tertile. Moreover, in the PLIC cohort, subjects in the 1st LCAT tertile showed a significantly faster impairment of kidney function compared to subjects in the 3rd LCAT tertile. Serum from subjects in the 1st LCAT tertile promoted a higher reactive oxygen species (ROS) production in renal cells compared to serum from subjects in the third LCAT tertile, and this effect was contrasted by pre-incubation with recombinant human LCAT (rhLCAT). The present study shows that reduced plasma LCAT concentration predicts CKD progression over time in patients with renal dysfunction, and, even more striking, it predicts the impairment of kidney function in the general population.

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Bao, Min, Xianliu Wang, Huihua Yuan, Xiangxin Lou, Qinghua Zhao, and Yanzhong Zhang. "HAp incorporated ultrafine polymeric fibers with shape memory effect for potential use in bone screw hole healing." Journal of Materials Chemistry B 4, no. 31 (2016): 5308–20. http://dx.doi.org/10.1039/c6tb01305h.

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Mangano, Francesco T., Mekibib Altaye, Robert C. McKinstry, Joshua S. Shimony, Stephanie K. Powell, Jannel M. Phillips, Holly Barnard, et al. "Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes." Journal of Neurosurgery: Pediatrics 18, no. 3 (September 2016): 306–19. http://dx.doi.org/10.3171/2016.2.peds15628.

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OBJECTIVE The purpose of this study was to investigate white matter (WM) structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy) and during the course of recovery after surgery in association with neuropsychological and behavioral outcome. METHODS This prospective study included 54 pediatric patients with congenital hydrocephalus (21 female, 33 male; age range 0.03–194.5 months) who underwent surgery and 64 normal controls (30 female, 34 male; age range 0.30–197.75 months). DTI and neurodevelopmental outcome data were collected once in the control group and 3 times (preoperatively and at 3 and 12 months postoperatively) in the patients with hydrocephalus. DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were extracted from the genu of the corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). Group analysis was performed first cross-sectionally to quantify DTI abnormalities at 3 time points by comparing the data obtained in the hydrocephalus group for each of the 3 time points to data obtained in the controls. Longitudinal comparisons were conducted pairwise between different time points in patients whose data were acquired at multiple time points. Neurodevelopmental data were collected and analyzed using the Adaptive Behavior Assessment System, Second Edition, and the Bayley Scales of Infant Development, Third Edition. Correlation analyses were performed between DTI and behavioral measures. RESULTS Significant DTI abnormalities were found in the hydrocephalus patients in both the gCC (lower FA and higher MD, AD, and RD) and the PLIC (higher FA, lower AD and RD) before surgery. The DTI measures in the gCC remained mostly abnormal at 3 and 12 months after surgery. The DTI abnormalities in the PLIC were significant in FA and AD at 3 months after surgery but did not persist when tested at 12 months after surgery. Significant longitudinal DTI changes in the patients with hydrocephalus were found in the gCC when findings at 3 and 12 months after surgery were compared. In the PLIC, trend-level longitudinal changes were observed between preoperative findings and 3-month postoperative findings, as well as between 3- and 12-month postoperative findings. Significant correlation between DTI and developmental outcome was found at all 3 time points. Notably, a significant correlation was found between DTI in the PLIC at 3 months after surgery and developmental outcome at 12 months after surgery. CONCLUSIONS The data showed significant WM abnormality based on DTI in both the gCC and the PLIC in patients with congenital hydrocephalus before surgery, and the abnormalities persisted in both the gCC and the PLIC at 3 months after surgery. The DTI values remained significantly abnormal in the gCC at 12 months after surgery. Longitudinal analysis showed signs of recovery in both WM structures between different time points. Combined with the significant correlation found between DTI and neuropsychological measures, the findings of this study suggest that DTI can serve as a sensitive imaging biomarker for underlying neuroanatomical changes and postsurgical developmental outcome and even as a predictor for future outcomes.

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Lošťáková, Vladimíra, Milan Kuna, Vítězslav Kolek, Filip Čtvrtlík, and Gabriela Vaculová. "Drug-induced lung injury." Klinická farmakologie a farmacie 32, no. 4 (January 1, 2019): 21–31. http://dx.doi.org/10.36290/far.2018.025.

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Skřičková, Jana, Bohdan Kadlec, and Ondřej Venclíček. "Non-small cell lung cancer." Vnitřní lékařství 63, no. 11 (November 1, 2017): 861–74. http://dx.doi.org/10.36290/vnl.2017.159.

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Hu, Haidai, Ákos Nemecz, Catherine Van Renterghem, Zaineb Fourati, Ludovic Sauguet, Pierre-Jean Corringer, and Marc Delarue. "Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation." Proceedings of the National Academy of Sciences 115, no. 17 (April 9, 2018): E3959—E3968. http://dx.doi.org/10.1073/pnas.1717700115.

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Pentameric ligand-gated ion channels (pLGICs) constitute a widespread class of ion channels, present in archaea, bacteria, and eukaryotes. Upon binding of their agonists in the extracellular domain, the transmembrane pore opens, allowing ions to go through, via a gating mechanism that can be modulated by a number of drugs. Even though high-resolution structural information on pLGICs has increased in a spectacular way in recent years, both in bacterial and in eukaryotic systems, the structure of the open channel conformation of some intensively studied receptors whose structures are known in a nonactive (closed) form, such as Erwinia chrysanthemi pLGIC (ELIC), is still lacking. Here we describe a gammaproteobacterial pLGIC from an endo-symbiont of Tevnia jerichonana (sTeLIC), whose sequence is closely related to the pLGIC from ELIC with 28% identity. We provide an X-ray crystallographic structure at 2.3 Å in an active conformation, where the pore is found to be more open than any current conformation found for pLGICs. In addition, two charged restriction rings are present in the vestibule. Functional characterization shows sTeLIC to be a cationic channel activated at alkaline pH. It is inhibited by divalent cations, but not by quaternary ammonium ions, such as tetramethylammonium. Additionally, we found that sTeLIC is allosterically potentiated by aromatic amino acids Phe and Trp, as well as their derivatives, such as 4-bromo-cinnamate, whose cocrystal structure reveals a vestibular binding site equivalent to, but more deeply buried than, the one already described for benzodiazepines in ELIC.

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Hu, Haidai, Rebecca J. Howard, Ugo Bastolla, Erik Lindahl, and Marc Delarue. "Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel." Proceedings of the National Academy of Sciences 117, no. 24 (June 1, 2020): 13437–46. http://dx.doi.org/10.1073/pnas.1922701117.

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Pentameric ligand-gated ion channels (pLGICs) are allosteric receptors that mediate rapid electrochemical signal transduction in the animal nervous system through the opening of an ion pore upon binding of neurotransmitters. Orthologs have been found and characterized in prokaryotes and they display highly similar structure–function relationships to eukaryotic pLGICs; however, they often encode greater architectural diversity involving additional amino-terminal domains (NTDs). Here we report structural, functional, and normal-mode analysis of two conformational states of a multidomain pLGIC, called DeCLIC, from aDesulfofustisdeltaproteobacterium, including a periplasmic NTD fused to the conventional ligand-binding domain (LBD). X-ray structure determination revealed an NTD consisting of two jelly-roll domains interacting across each subunit interface. Binding of Ca2+at the LBD subunit interface was associated with a closed transmembrane pore, with resolved monovalent cations intracellular to the hydrophobic gate. Accordingly, DeCLIC-injected oocytes conducted currents only upon depletion of extracellular Ca2+; these were insensitive to quaternary ammonium block. Furthermore, DeCLIC crystallized in the absence of Ca2+with a wide-open pore and remodeled periplasmic domains, including increased contacts between the NTD and classic LBD agonist-binding sites. Functional, structural, and dynamical properties of DeCLIC paralleled those of sTeLIC, a pLGIC from another symbiotic prokaryote. Based on these DeCLIC structures, we would reclassify the previous structure of bacterial ELIC (the first high-resolution structure of a pLGIC) as a “locally closed” conformation. Taken together, structures of DeCLIC in multiple conformations illustrate dramatic conformational state transitions and diverse regulatory mechanisms available to ion channels in pLGICs, particularly involving Ca2+modulation and periplasmic NTDs.

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Air, Ellen L., Weihong Yuan, Scott K. Holland, Blaise V. Jones, Karin Bierbrauer, Mekibib Altaye, and Francesco T. Mangano. "Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus." Journal of Neurosurgery: Pediatrics 5, no. 4 (April 2010): 385–91. http://dx.doi.org/10.3171/2009.11.peds09343.

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Object The goal in this study was to compare the integrity of white matter before and after ventriculoperitoneal (VP) shunt insertion by evaluating the anisotropic diffusion properties with the aid of diffusion tensor (DT) imaging in young children with hydrocephalus. Methods The authors retrospectively identified 10 children with hydrocephalus who underwent both pre- and postoperative DT imaging studies. The DT imaging parameters (fractional anisotropy [FA], mean diffusivity, axial diffusivity, and radial diffusivity) were computed and compared longitudinally in the splenium and genu of the corpus callosum (gCC) and in the anterior and posterior limbs of the internal capsule (PLIC). The patients' values on DT imaging at the pre- and postshunt stages were compared with the corresponding age-matched controls as well as with a large cohort of healthy children in the database. Results In the gCC, 7 of 10 children had abnormally low preoperative FA values, 6 of which normalized postoperatively. All 3 of the 10 children who had normal preoperative FA values had normal FA values postoperatively as well. In the PLIC, 7 of 10 children had abnormally high FA values, 6 of which normalized postoperatively, whereas the other one had abnormally low postoperative FA. Of the remaining 3 children, 2 had abnormally low preoperative FA values in the PLIC; this normalized in 1 patient after surgery. The other child had a normal preoperative FA value that became abnormally low postoperatively. When comparing the presurgery frequency of abnormally low, normal, and abnormally high FA values to those postsurgery, there was a statistically significant longitudinal difference in both gCC (p = 0.02) and PLIC (p = 0.002). Conclusions In this first longitudinal DT imaging study of young children with hydrocephalus, DT imaging anisotropy yielded abnormal results in several white matter regions of the brain, and trended toward normalization following VP shunt placement.

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Palotai, M., H. L. Weiner, T. Chitnis, J. F. Duffy, and C. R. Guttmann. "1128 Sleep Apnea and Periodic Limb Movements are Highly Prevalent in Patients With Multiple Sclerosis." Sleep 43, Supplement_1 (April 2020): A429—A430. http://dx.doi.org/10.1093/sleep/zsaa056.1122.

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Abstract Introduction The pathogenesis of multiple sclerosis (MS)-related fatigue is multi-factorial, including neurogenic, inflammatory, endocrine, metabolic, mood, as well as sleep disorder-related mechanisms. The confounding effect of sleep disorders on the association between fatigue and neurodegenerative changes in the brain has not been investigated. Our objectives were to assess the prevalence of sleep apnea and periodic limb movements in the framework of a prospective study which investigates the neurogenic causation of treatment-resistant fatigue in MS. Methods MS patients enrolled in a National MS Society-funded prospective study (grant identifier RG-1501-03141) underwent a one-night at-home sleep test (HST) using a NOX T3 portable monitor. HST recordings were scored by a registered polysomnographic technologist. Respiratory Event (REI) and Periodic Limb Movement (PLMI) Indices were calculated for each patient. Results Out of 36 patients, 7 (20%) had mild (REI=5-14), 1 (3%) had moderate (REI=15-29), and 1 (3%) had severe sleep-disordered breathing (REI≥30). Fourteen (42%) of the patients had mild (PLMI=5-24), 4 (11%) had moderate (PLMI=25-49), and 7 (19%) had severe periodic limb movements (PLMI≥50). Overall, 81% of the patients had at least mild sleep-disordered breathing and/or periodic limb movements. Conclusion Sleep abnormalities (i.e., sleep apnea and periodic limb movements) are highly prevalent in patients with MS. We plan to compare the MRI exams of subgroups of MS patients with fatigue, to test the hypothesis that fronto-striatal circuitry is more affected by lesions in patients without sleep apnea compared to those with sleep apnea. Support This investigation was supported by a grant from the National Multiple Sclerosis Society (grant identifier RG-1501-03141). The home sleep test equipment was provided by a DURIP grant from the Office of Naval Research (grant N00014-15-1-2917).

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Chiodo, L., M. Casula, A. L. Catapano, A. Baragetti, K. Garlaschelli, L. Grigore, E. Loggia, et al. "Characterization of metabolic syndrome in PLIC cohort." Nutrition, Metabolism and Cardiovascular Diseases 27, no. 1 (January 2017): e14. http://dx.doi.org/10.1016/j.numecd.2016.11.038.

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Casula, Manuela, Lorenzo Chiodo, Andrea Baragetti, Katia Garlaschelli, Liliana Grigore, Giuseppe Danilo Norata, Fabio Pellegatta, et al. "Characterization of metabolic syndrome in PLIC cohort." Atherosclerosis 263 (August 2017): e181. http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.582.

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Tynchenko, V. S., V. V. Kukartsev, A. I. Cherepanov, V. E. Petrenko, and N. N. Dzhioeva. "Development of PLIC-based time synchronization device." Journal of Physics: Conference Series 1728 (January 2021): 012022. http://dx.doi.org/10.1088/1742-6596/1728/1/012022.

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Rodríguez Garcés, Carlos René, and Johana Andrea Muñoz Soto. "Participación laboral de las mujeres rurales chilenas: tendencias, perfiles y factores predictores." Cuadernos de Desarrollo Rural 12, no. 75 (March 16, 2015): 22. http://dx.doi.org/10.11144/javeriana.cdr12-75.plmc.

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Mediante un Modelo de Regresión Logística se analiza la participación laboral de las mujeres rurales y losfactores asociados. Se observa un aumento en la tasa de participación con reducidos niveles de desempleo,no obstante persistir brechas y precarización de las condiciones de trabajo. Mujeres con mejor preparacióny con actitudes más favorables hacia el trabajo generan ingresos, sostienen familia, desarrollan procesos deempoderamiento. Favorecen la probabilidad de estar empleada: número perceptores de ingreso y de hijos/as, ser jefa de hogar, escolaridad, edad. Son factores inhibidores: tener hijos/as menores o en edad preescolar,tener pareja y disponer de mayor ingreso no dependiente del aporte femenino.

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Minárik, Marek. "Molecular profiling of lung cancer." Onkologie 10, no. 1 (March 1, 2016): 7–10. http://dx.doi.org/10.36290/xon.2016.003.

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Koubková, Leona. "Antiangiogenic therapy of lung cancer." Onkologie 12, no. 5 (October 15, 2018): 231–34. http://dx.doi.org/10.36290/xon.2018.042.

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Jakubec, Petr, Monika Žurková, Lenka Hajdová, Aneta Křenková, and Vítězslav Kolek. "The complications after lung transplantation." Vnitřní lékařství 63, no. 11 (November 1, 2017): 848–59. http://dx.doi.org/10.36290/vnl.2017.158.

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Zurutuza, Unai, and Julen Castellano. "Comparación de la respuesta física, en términos absolutos y relativos a la competición, de diferentes demarcaciones en tareas jugadas de fútbol." Cuadernos de Psicología del Deporte 20, no. 1 (December 22, 2019): 190–200. http://dx.doi.org/10.6018/cpd.402291.

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El objetivo fue estudiar las demandas externas absolutas y relativas respecto a la competición de diferentes formatos de juego en el fútbol teniendo en cuenta las diferentes demarcaciones de los jugadores. Se registraron cuatro variables externas en 20 jugadores semiprofesionales en cuatro tipos de tareas jugadas (4vs4 o JRP, 6vs6 o JRM y 8vs8 o JRL) y partidos de entrenamiento (10vs10 o PE) para un total de 467 registros. Las variables externas fueron: la distancia total (DTmin y %DT) y carga del jugador (PLmin y %PL), en valores absolutos por minuto de práctica y en valores relativos al perfil de las demandas en competición. Los resultados fueron que: en formatos más pequeños (JRP y JRM) con pocos jugadores la demanda en términos absolutos (en m por min-1) fue similar entre las diferentes demarcaciones, pero no así en términos relativos a las demandas de la competición. Por el contrario, las diferencias entre las diferentes posiciones de juego se minimizan en los formatos más grandes JRL y PE cuando se expresaron en términos relativos a la competición, pero no así en términos absolutos, donde existen diferencias. La conclusión del estudio es que las diferencias en las demandas entre las demarcaciones varían entre los formatos de juego, y, además, estas diferencias se incrementan o se equiparan según se consideren los valores en términos absolutos o relativos al perfil de competición individual. Los resultados sugieren que los entrenadores deberían considerar todo el espectro de tareas (e.g., desde 1vs1 a 10vs10) para atender a las necesidades particulares de cada demarcación y contextualizado a los objetivos técnico-tácticos y condicionales deseados con el propósito de optimizar su rendimiento. The objective was to study the physical response to conditional performance in competition of different game formats in football taking into account the demarcation of players. Four external load variables were recorded in 16 semi-professional players in four types of tasks played (4vs4 [JRP], 6vs6 [JRM] and 8vs8 [JRL]) and training matches (10vs10 [PE]) for a total of 467 records. The physical variables analyzed were the following: (a) DTmin, total distance in absolute values per minute of activity, (b) %DT, total distance per minute in values relative to the profile of demands in competition, (c) PLmin, player load in absolute values per minute of activity, and (d) %PL, player load per minute in values relative to the profile of demands in competition. The results were that in the JRP and JRM formats for the variables DTmin and PLmin the values were similar between demarcations, but not being the same for the variables %DT and %PL. On the contrary, the differences between the different game positions were minimized in the large formats (JRL and PE) when the %DT and %PL variables were analyzed, as opposed to DTmin and PLmin, where there were more differences between demarcations. The conclusion was that, depending on whether the physical variables are considered in absolute terms or in relation to the competition, the differences between demarcations are not uniform: small formats equal the conditional response in absolute terms, while large formats equal the conditional response between players in terms of the individual profile in competition. O objetivo era estudar a resposta física ao desempenho condicional na competição de diferentes formatos de jogo no futebol, levando em conta a demarcação dos jogadores. Quatro variáveis de carga externa foram registradas em 16 jogadores semi-profissionais em quatro tipos de tarefas jogadas (4vs4 [JRP], 6vs6 [JRM] e 8vs8 [JRL]) e partidas de treinamento (10vs10 [PE]) para um total de 467 registros. As variáveis físicas analisadas foram as seguintes: (a) DTmin, distância total em valores absolutos por minuto de atividade, (b) %DT, distância total por minuto em valores relativos ao perfil de exigências na competição, (c) PLmin, carga de jogadores em valores absolutos por minuto de atividade, e (d) %PL, carga de jogadores por minuto em valores relativos ao perfil de exigências na competição. Os resultados foram que nos formatos JRP e JRM para as variáveis DTmin e PLmin os valores foram semelhantes entre as demarcações, mas não sendo os mesmos para as variáveis %DT e %PL. Pelo contrário, as diferenças entre as diferentes posições de jogo foram minimizadas nos grandes formatos (JRL e PE) quando as variáveis %DT e %PL foram analisadas, ao contrário do DTmin e PLmin, onde houve mais diferenças entre as demarcações. A conclusão foi que, dependendo se as variáveis físicas são consideradas em termos absolutos ou em relação à competição, as diferenças entre demarcações não são uniformes: formatos pequenos igualam a resposta condicional em termos absolutos, enquanto formatos grandes igualam a resposta condicional entre jogadores em termos do perfil individual em competição.

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Saincher, Shaswat, and Jyotirmay Banerjee. "A Redistribution-Based Volume-Preserving PLIC-VOF Technique." Numerical Heat Transfer, Part B: Fundamentals 67, no. 4 (December 10, 2014): 338–62. http://dx.doi.org/10.1080/10407790.2014.950078.

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Gurin, E. I., L. E. Dyatlov, N. N. Konnov, K. V. Popov, and A. V. Sevast'yanov. "A Vernier Time-Interval Measurer on a PLIC." Instruments and Experimental Techniques 47, no. 4 (July 2004): 459–63. http://dx.doi.org/10.1023/b:inet.0000038388.84416.36.

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Aker, Karoline, Ragnhild Støen, Live Eikenes, Miriam Martinez-Biarge, Ingeborg Nakken, Asta Kristine Håberg, Sridhar Gibikote, and Niranjan Thomas. "Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy in India (THIN study): a randomised controlled trial." Archives of Disease in Childhood - Fetal and Neonatal Edition 105, no. 4 (October 29, 2019): 405–11. http://dx.doi.org/10.1136/archdischild-2019-317311.

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ObjectiveTo evaluate the neuroprotective effect of therapeutic hypothermia (TH) induced by phase changing material (PCM) on MRI biomarkers in infants with hypoxic-ischaemic encephalopathy (HIE) in a low-resource setting.DesignOpen-label randomised controlled trial.SettingOne neonatal intensive care unit in a tertiary care centre in India.Patients50 term/near-term infants admitted within 5 hours after birth with predefined physiological criteria and signs of moderate/severe HIE.InterventionsStandard care (n=25) or standard care plus 72 hours of hypothermia (33.5°C±0.5°C, n=25) induced by PCM.Main outcome measuresPrimary outcome was fractional anisotropy (FA) in the posterior limb of the internal capsule (PLIC) on neonatal diffusion tensor imaging analysed according to intention to treat.ResultsPrimary outcome was available for 22 infants (44%, 11 in each group). Diffusion tensor imaging showed significantly higher FA in the cooled than the non-cooled infants in left PLIC and several white matter tracts. After adjusting for sex, birth weight and gestational age, the mean difference in PLIC FA between groups was 0.026 (95% CI 0.004 to 0.048, p=0.023). Conventional MRI was available for 46 infants and demonstrated significantly less moderate/severe abnormalities in the cooled (n=2, 9%) than in the non-cooled (n=10, 43%) infants. There was no difference in adverse events between groups.ConclusionsThis study confirmed that TH induced by PCM reduced brain injury detected on MRI in infants with moderate HIE in a neonatal intensive care unit in India. Future research should focus on optimal supportive treatment during hypothermia rather than looking at efficacy of TH in low-resource settings.Trial registration numberCTRI/2013/05/003693.

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Ambroz, Petr, Jana Janoutová, and Vladimír Janout. "Lung Cancer and HPV Infections." Hygiena 61, no. 4 (December 1, 2016): 172–75. http://dx.doi.org/10.21101/hygiena.a1460.

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Pešek, Miloš. "New WHO classification of lung tumours." Onkologie 10, no. 1 (March 1, 2016): 20–24. http://dx.doi.org/10.36290/xon.2016.002.

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Zemanová, Milada. "Advances in radiotherapy for lung cancer." Onkologie 12, no. 4 (September 1, 2018): 155–60. http://dx.doi.org/10.36290/xon.2018.029.

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Kociánová, Jana. "Spirometry - basic examination of the lung function." Vnitřní lékařství 63, no. 11 (November 1, 2017): 889–94. http://dx.doi.org/10.36290/vnl.2017.162.

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Arakaki, Reinaldo Gen Ichiro, and Luiz Antonio Nogueira Lorena. "Uma heurística de localização-alocação (HLA) para problemas de localização de facilidades." Production 16, no. 2 (August 2006): 319–28. http://dx.doi.org/10.1590/s0103-65132006000200011.

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Neste trabalho, foi desenvolvida uma nova heurística de localização-alocação (HLA) para problemas de localização de facilidades (facility). Em tais problemas a questão central é localizar um objeto ou mais objetos, que são chamados de facilidades, e minimizar o custo de localizar estas facilidades. A HLA foi aplicada a dois problemas: o Problema de Localização de Máxima Cobertura (PLMC) e o Problema das P-Medianas Capacitado (PPMC) com o intuito de uma possível integração a Sistemas de Informações Geográficas (SIG). A HLA baseia-se na formação de agrupamentos (clusters) e na possibilidade de melhorá-los (em relação a algum objetivo). Uma bateria de problemas testes foi escolhida para validar a HLA. Bons resultados foram encontrados para o PLMC para instâncias (instance) pequenas e grandes, e para o PPMC em instâncias pequenas. Conclui-se que a HLA, sendo uma heurística de simples implementação, é rápida e bastante eficiente, portanto, indicada para ser integrada aos SIG.

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Yuan, Weihong, Charles B. Stevenson, Mekibib Altaye, Blaise V. Jones, James Leach, Mykhailo Lovha, Noa Rennert, and Francesco T. Mangano. "Diffusion tensor imaging in children following prenatal myelomeningocele repair and its predictive value for the need and timing of subsequent CSF diversion surgery for hydrocephalus." Journal of Neurosurgery: Pediatrics 27, no. 4 (April 2021): 391–99. http://dx.doi.org/10.3171/2020.9.peds20570.

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OBJECTIVE The aim of this study was to investigate diffusion tensor imaging (DTI), an objective and noninvasive neuroimaging technique, for its potential as an imaging biomarker to predict the need and timing of CSF diversion surgery in patients after prenatal myelomeningocele (MMC) repair. METHODS This was a retrospective analysis of data based on 35 pediatric patients after prenatal MMC repair (gestational age at birth 32.68 ± 3.42 weeks, range 24–38 weeks; 15 females and 20 males). A logistic regression analysis was used to classify patients to determine the need for CSF diversion surgery. The model performance was compared between using the frontooccipital horn ratio (FOHR) alone and using the FOHR combined with DTI values (the genu of the corpus callosum [gCC] and the posterior limb of the internal capsule [PLIC]). For patients who needed to be treated surgically, timing of the procedure was used as the clinical outcome to test the predictive value of DTI acquired prior to surgery based on a linear regression analysis. RESULTS Significantly lower fractional anisotropy (FA) values in the gCC (p = 0.014) and PLIC (p = 0.037) and higher mean diffusivity (MD) values in the gCC (p = 0.013) were found in patients who required CSF diversion surgery compared with those who did not require surgery (all p values adjusted for age). Based on the logistic regression analysis, the FOHR alone showed an accuracy of performance of 0.69 and area under the receiver operating characteristic curve (AUC) of 0.60. The performance of the model was higher when DTI measures were used in the logistic regression model (accuracy = 0.77, AUC = 0.84 for using DTI values in gCC; accuracy = 0.75, AUC = 0.84 for using DTI values in PLIC). Combining the DTI values of the gCC or PLIC and FOHR did not improve the model performance when compared with using the DTI values alone. In patients who needed CSF diversion surgery, significant correlation was found between DTI values in the gCC and the time interval between imaging and surgery (FA: ρ = 0.625, p = 0.022; MD: ρ = −0.6830, p = 0.010; both adjusted for age and FOHR). CONCLUSIONS The authors’ data demonstrated that DTI could potentially serve as an objective biomarker differentiating patients after prenatal MMC repair regarding those who may require surgery for MMC-associated hydrocephalus. The predictive value for the need and timing of CSF diversion surgery is highly clinically relevant for improving and optimizing decision-making for the treatment of hydrocephalus in this patient population.

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Tillman, Tommy, Mary H. Cheng, Qiang Chen, Pei Tang, and Yan Xu. "Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaesthetics." Biochemical Journal 449, no. 1 (December 7, 2012): 61–68. http://dx.doi.org/10.1042/bj20121072.

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pLGICs (pentameric ligand-gated ion channels) are a family of structurally homologous cation and anion channels involved in neurotransmission. Cation-selective members of the pLGIC family are typically inhibited by general anaesthetics, whereas anion-selective members are potentiated. GLIC is a prokaryotic cation pLGIC and can be inhibited by clinical concentrations of general anaesthetics. The introduction of three mutations, Y221A (Y-3′A), E222P (E-2′P) and N224R (N0′R), at the selectivity filter and one, A237T (A13′T), at the hydrophobic gate, converted GLIC into an anion channel. The mutated GLIC (GLIC4) became insensitive to the anaesthetics propofol and etomidate, as well as the channel blocker picrotoxin. MD (molecular dynamics) simulations revealed changes in the structure and dynamics of GLIC4 in comparison with GLIC, particularly in the tilting angles of the pore-lining helix [TM2 (transmembrane helix 2)] that consequently resulted in different pore radius and hydration profiles. Propofol binding to an intra-subunit site of GLIC shifted the tilting angles of TM2 towards closure at the hydrophobic gate region, consistent with propofol inhibition of GLIC. In contrast, the pore of GLIC4 was much more resilient to perturbation from propofol binding. The present study underscores the importance of pore dynamics and conformation to anaesthetic effects on channel functions.

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Heir, Renu, Celine Ablasou, Emilie Dumontier, Meghan Elliott, Christine Fagotto‐Kaufmann, and Fiona K. Bedford. "The UBL domain of PLIC‐1 regulates aggresome formation." EMBO reports 7, no. 12 (November 3, 2006): 1252–58. http://dx.doi.org/10.1038/sj.embor.7400823.

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Mencinger, Jure, and Iztok Žun. "A PLIC–VOF method suited for adaptive moving grids." Journal of Computational Physics 230, no. 3 (February 2011): 644–63. http://dx.doi.org/10.1016/j.jcp.2010.10.010.

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Nahed, Jean, and Joseph Dgheim. "Estimation curvature in PLIC-VOF method for interface advection." Heat and Mass Transfer 56, no. 3 (September 11, 2019): 773–87. http://dx.doi.org/10.1007/s00231-019-02737-4.

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Satheesan, Arun Puliyasserimana, Ashwini R. Chinnappa, Guruprasad Goudar, and Chaitali Raghoji. "Correlation between early magnetic resonance imaging brain abnormalities in term infants with perinatal asphyxia and neuro developmental outcome at one year." International Journal of Contemporary Pediatrics 7, no. 10 (September 21, 2020): 1957. http://dx.doi.org/10.18203/2349-3291.ijcp20204002.

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Background: Hypoxic ischemic encephalopathy is an important cause of permanent brain damage in neonates with perinatal asphyxia. Magnetic resonance imaging (MRI) is valuable in predicting prognosis following HIE.Methods: Prospective observational cohort study was conducted in tertiary level referral hospital in term infants born with perinatal asphyxia. MRI brain was done between 5 to 14 days of age. Anthropometry and neurological examinations were recorded at birth, discharge and follow-up. Denver developmental screening test II was performed at follow up.Results: Out of 174 neonates born with PA, enrolled 64 underwent MRI brain. Out of these 14% had stage I, 70% stage II and 16 % stage III HIE as per Sarnat staging. At follow up, abnormalities in tone were noted in 36% infants, which included spastic quadriplegia in 34% and atonic cerebral palsy in 2%. DDST II was normal in 32 and suspect in 18 (36%) infants; with global developmental delay in 14 (28%) and predominantly motor development delay in 4 (8%). Abnormal lesions were seen in the corpus callosum in 34 (68%), posterior limb of internal capsule in 14 (28%), basal ganglia in 11 (22%), watershed region in 6 (12%), thalamus in 4 (8%) and corticospinal tract in 1 (2%) infants were associated with statistical significant poor neurodevelopment outcome p<0.05. Diffusion weighted MRI showed abnormalities in the posterior limb of internal capsule (PLIC) in 27 (54%), BG in 8 (16%) and thalamus in 2 (4%) infants was associated with statistically significant poor neurodevelopmental outcome (NDO) (p<0.05).Conclusions: Lesion in BG, thalamic region and PLIC in conventional MRI and abnormality in DW imaging in PLIC and BG were found to correlate with poor NDO at one year of life.

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Serranová, Tereza, Matěj Slovák, David Kemlink, Karel Šonka, Mark Hallett, and Evžen Růžička. "Prevalence of restless legs syndrome in functional movement disorders: a case–control study from the Czech Republic." BMJ Open 9, no. 1 (January 2019): e024236. http://dx.doi.org/10.1136/bmjopen-2018-024236.

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ObjectivesThe prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Therefore, our objective was to evaluate possible association between FMD and RLS.DesignCase–control study.SettingMovement Disorders Center, 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic.Participants96 consecutive patients with clinically established FMD (80 females, mean age (SD) 45.0 (13) years), and 76 matched controls.Primary and secondary outcome measuresThe primary outcome measure was prevalence of RLS based on updated International RLS Study Group criteria. Secondary outcome measures included prevalence of periodic limb movements (PLM) using actigraphy; pain, motor and sensory symptoms in lower limbs; organic comorbidities and medication affecting RLS.ResultsRLS criteria were fulfilled in 43.8% of patients (95% CI 34 to 54) and in 7.9% of controls (95% CI 3 to 17, p<0.00001). Both RLS and PLM indices (PLMi) ≥22.5/hour were found in 21.2% of patients with FMD and 2.6% of controls. Patients with FMD with RLS had a higher mean PLMi (p<0.001) and a higher proportion of PLMi ≥22.5/hour (p<0.01) than RLS-negative patients. Patients with RLS had higher prevalence of pain and sensory symptoms in lower limbs, no difference was found in medication and prevalence of organic comorbidities in patients with FMD with and without RLS.ConclusionsWe found an increased prevalence of RLS in patients with FMD. Clinical diagnosis of RLS was supported by actigraphic measurement of clinically relevant PLM in a significant proportion of patients with FMD. Although functional motor and sensory symptoms may mimic RLS, RLS may be unrecognised in patients with FMD. This finding may have clinical implications in management of FMD, and it raises the possibility of common pathophysiological mechanisms of FMD and RLS/PLM.

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Barker, Lina, and Maja Tippmann-Peikert. "533 Characteristics of patients with REM sleep without atonia (RSWA)/persistent periodic limb movements of sleep (PLMS) in REM sleep." Sleep 44, Supplement_2 (May 1, 2021): A209—A211. http://dx.doi.org/10.1093/sleep/zsab072.531.

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Abstract Introduction While RSWA in REM sleep behavior disorder (RBD) is associated with male sex, age > 50 years, alpha-synucleinopathies, and narcolepsy, the characteristics of patients with RSWA/PLMS in REM sleep (RSWA/PLMS-REM) without dream enactment behaviors are unexplored. The aim of this study was to compare the demographics, comorbidities and concomitant medication use between RSWA/PLMS-REM patients and non-RSWA/non-PLMS-REM controls. Based on anecdotal clinical observations we hypothesized that these patients are more commonly young, women, have psychiatric or neurological diseases, and use antidepressants. Methods We conducted a retrospective review of the Mayo Clinic electronic medical record to identify all patients with RSWA/ PLMS-REM between November 2018 and November 2020. After excluding all patients with RBD, restless legs syndrome, narcolepsy and RSWA/non-PLMS-REM we identified 27 patients. All PSGs were reviewed to calculate the periodic limb movement index per hour of REM sleep (REM-PLMI). We also identified a covenience sample of 15 non-RSWA controls, reviewed their PSGs and calculated REM-PLMI. Results The mean REM-PLMI of patients with RSWA was 64+/-8.3 (SEM)/hour versus 1+/-0.6 (SEM)/hours in non-RSWA controls (p< 0.001). Patients with RSWA/PLMS-REM and non-RSWA controls had similar age and gender, 62 +/- 3 (SEM) versus 58 +/-3 (SEM) years and 81% versus 87% men, respectively. However psychiatric diagnosis, neurological disorders and antidepressants use was more common among RSWA/PLMS-REM patients compared to non-RSWA controls, p=0.0002, p=0.0035 and p=0.0074, respectively. (Fisher’s Exact Test) Conclusion Psychiatric diagnosis, neurological disorders and antidepressant use are more common among RSWA/PLM-REM patients compared to non-RSWA controls. Further research to determine the implications of a diagnosis of RSWA/PLMS-REM for the future development of alpha-synucleinopathies are needed and currently ongoing. Support (if any):

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Xing, Qing-Na, Yan-Chao Liu, De-Sheng Xuan, Hong-Lei Shang, Xin Zhao, and Xiao-An Zhang. "Diagnostic Value of Diffusion Tensor Imaging for Infants’ Brain Development Retardation Caused by Pre-Eclampsia." Contrast Media & Molecular Imaging 2021 (July 15, 2021): 1–7. http://dx.doi.org/10.1155/2021/5545178.

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Objective. Pre-eclampsia (PE) can cause brain development delay in infants. This work aims to characterize the pattern differences of brain white matter development in premature infants under PE conditions and those without. Methods. Eighty preterm infants delivered by women with PE were selected as the PE group, and ninety-six preterm infants of the same period born to women without high-risk perinatal factors were used as control. All infants underwent diffusion tensor imaging (DTI) examination. The fractional anisotropy (FA) was measured in five regions of interests (ROIs), including posterior limbs of internal capsule (PLIC), splenium of the corpus callosum (SCC), superior frontal gyrus (SFG), superior parietal lobule (SPL), and superior occipital gyrus (SOG). The relationship between the FA values and postmenstrual age (PMA) was analyzed. Results. After adjusting for the birth weight and gestational ages, in the SCC and PLIC, the PMA and FA values showed a low-to-medium intensity positive correlation in the control group (r = 0.30, p = 0.003 ; r = 0.53, p < 0.0001 ), while no positive relevance was detected in the PE group (r = 0.08, p = 0.47 ; r = 0.19, p < 0.08 ). In the PE and control groups, in the SPL and SOG, the PMA and FA values showed a near-consistent positive correlation (r = 0.57, r = 0.55 vs. r = 0.31, r = 0.55; all p < 0.05 ). In the control group, in SFG, the PMA and FA values had a medium intensity positive correlation (r = 0.47, p < 0.0001 ), but there was no statistical difference in correlation in PE (r = 0.10, p = 0.39 ). Conclusion. PE may cause lagging brain development in the SCC, PLIC, and SFG during infancy. DTI may be an effective and sensitive detection tool.

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Mollica, Cristina, and Luca Tardella. "PLMIX: an R package for modelling and clustering partially ranked data." Journal of Statistical Computation and Simulation 90, no. 5 (January 12, 2020): 925–59. http://dx.doi.org/10.1080/00949655.2020.1711909.

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Pešek, Miloš. "Current treatment options for squamous cell carcinoma of the lung." Onkologie 12, no. 4 (September 1, 2018): 161–67. http://dx.doi.org/10.36290/xon.2018.030.

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Špirudová, Lenka, and Jaroslav Nol. "Quality of life of patients after lung transplantation." Kontakt 16, no. 1 (March 21, 2014): e9-e16. http://dx.doi.org/10.1016/j.kontakt.2013.12.002.

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Moraga-Cid, Gustavo, Ludovic Sauguet, Christèle Huon, Laurie Malherbe, Christine Girard-Blanc, Stéphane Petres, Samuel Murail, et al. "Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure." Proceedings of the National Academy of Sciences 112, no. 9 (February 17, 2015): 2865–70. http://dx.doi.org/10.1073/pnas.1417864112.

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The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutations altering the allosteric transitions of activation or desensitization. We previously showed that the TMD of the human α1GlyR could be fused to the extracellular domain of GLIC, a bacterial pLGIC, to form a functional chimera called Lily. Here, we overexpress Lily in Schneider 2 insect cells and solve its structure by X-ray crystallography at 3.5 Å resolution. The TMD of the α1GlyR adopts a closed-channel conformation involving a single ring of hydrophobic residues at the center of the pore. Electrophysiological recordings show that the phenotypes of key allosteric mutations of the α1GlyR, scattered all along the pore, are qualitatively preserved in this chimera, including those that confer decreased sensitivity to agonists, constitutive activity, decreased activation kinetics, or increased desensitization kinetics. Combined structural and functional data indicate a pore-opening mechanism for the α1GlyR, suggesting a structural explanation for the effect of some key hyperekplexic allosteric mutations. The first X-ray structure of the TMD of the α1GlyR solved here using GLIC as a scaffold paves the way for mechanistic investigation and design of allosteric modulators of a human receptor.

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Salazar, Hugo, Julen Castellano, and Luka Svilar. "Differences in External Load Variables Between Playing Positions in Elite Basketball Match-Play." Journal of Human Kinetics 75, no. 1 (October 31, 2020): 257–66. http://dx.doi.org/10.2478/hukin-2020-0054.

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Abstract The purpose of this study was to describe the specific demands and structure of interrelationships of external load variables in order to generate a position-related time motion profile in elite basketball. Seventeen professional players from three different playing positions (6 guards, 4 forwards, and 7 centers) were analyzed in five friendly games. Player load per minute (PLmin) was used as an indicator of intensity to compare positions. Furthermore, high and total external variables of jumping (hJUMP and tJUMP), acceleration (hACC and tACC), deceleration (hDEC and tDEC) and change of direction (hCOD and tCOD), respectively, were used for the principal component analysis (PCA). The Kaiser criterion (eigenvalue > 1) was applied, and the Varimax rotation mode was used to extract multiple principal components. PCA showed that all positions had three or four principal components, but the configuration of each factor was different: tCOD, hCOD, hDEC and hJUMP for guards, hCOD, tCOD, tACC and hDEC for forwards, and tJUMP, hJUMP, hDEC and tACC for centers were specifically demanded in match-play. For guards and forwards, a significant correlation was found between COD variables, while for centers tCOD and PLmin had the strongest correlation. When monitoring the external load via tri-axial accelerometers in basketball match-play, each playing position showed specific physical demands. Therefore, these variables must be prioritized in load monitoring programs.

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Alhmoud, Lina, and Ali Khudhair Al-Jiboory. "Synthesis Conditions for LPV Controller with Input Covariance Constraints." Open Engineering 9, no. 1 (June 4, 2019): 144–50. http://dx.doi.org/10.1515/eng-2019-0018.

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AbstractIn this paper, novel synthesis conditions for state-feedback Linear Parameter Varying (LPV) controller with Input Covariance Constraints (ICC) are developed. The synthesis conditions achieve the following design requirements 1) some constraints need to be satisfied on the control energy and 2) optimizing the performance outputs for the entire parameter space of the LPV system. These conditions are formulated as convex optimization problem with Parameterized Linear Matrix Inequalities (PLMIs) constraints. The effectiveness of the proposed approach is illustrated through numerical examples.

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