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Academic literature on the topic 'Platinum complexes'

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Published: 4 June 2021
Last updated: 6 September 2023

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Journal articles on the topic "Platinum complexes"

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&NA;. "Platinum complexes." Reactions Weekly &NA;, no. 508 (July 1994): 12. http://dx.doi.org/10.2165/00128415-199405080-00062.

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Al-Allaf, Talal A. K., and Abeer Z. M. Sheet. "Platinum group metal Schiff base complexes—I. Platinum complexes." Polyhedron 14, no. 2 (January 1995): 239–48. http://dx.doi.org/10.1016/0277-5387(94)00231-3.

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Bednarski, Patrick, Fiona Mackay, and Peter Sadler. "Photoactivatable Platinum Complexes." Anti-Cancer Agents in Medicinal Chemistry 7, no. 1 (January 1, 2007): 75–93. http://dx.doi.org/10.2174/187152007779314053.

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Kiwada, Tatsuto, Hiromu Katakasu, Serina Okumura, and Akira Odani. "Characterization of platinum(II) complexes exhibiting inhibitory activity against the 20S proteasome." Royal Society Open Science 7, no. 8 (August 2020): 200545. http://dx.doi.org/10.1098/rsos.200545.

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Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure–activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver–Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure–activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.
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Chung, Min Chul, Woong Kyu Jo, Seak Hwan Son, Chee Hun Kwak, Ji Hoon Lee, and Ho Geun Ahn. "Synthesis and Characterization of the Monomeric Platinum(II) Complexes with 2,2’-Bipyridine Back-Bone Ligand." Advanced Materials Research 554-556 (July 2012): 811–15. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.811.

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The reaction of platinum(II) complexes of [Pt(bpy-R)Cl2] (R = H; 2,2’-bipyridine(bpy), R = 2(CH)3; 4,4’-dimethyl-2,2’-biypridine (DM-bpy), R = 4(CH3); 3,3’-5,5’-tertamethyl-2,2’-bipyridiyl (TM-bpy), (1-3) or [Pt(1,10-phen-R’)Cl2] (R’ = H; 1,10-phenanthroline(1,10-phen), R’= 4(CH3); 3,4,7,8-tetramethyl-1,10-phenanthroline(3,4,7,8-tetramethyl-1,10-phen) (4-5) with 1,4-bis(5'-2',2"-bipyridine)benzene(bpy-Ph-bpy) affords the following monomeric platinium(II) complexes: [Pt(bpy)(bpy-Ph-bpy)]2+(1), [Pt(DM-bpy)(bpy-Ph-bpy)](2), and [Pt(TM-bpy)(bpy-ph-bpy)]2+(3), [Pt(1,10-phenanthroline)(bpy-ph-bpy)]2+2+(4), [Pt(3,4,7,82+-tetramethyl-1,10-phen)(bpy-ph-bpy)]2+(5), respectively. These complexes were characterized by NMR, IR, UV/VIS and PL spectroscopy of the complexes were elucidated. The internal quantum yields of these platinum complexes are very high (0.13 ~ 0.99) and they emit light in the blue region (360 ~ 417 nm).
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Coffetti, Giulia, Martina Moraschi, Giorgio Facchetti, and Isabella Rimoldi. "The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives." Molecules 28, no. 8 (April 12, 2023): 3407. http://dx.doi.org/10.3390/molecules28083407.

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One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in trans conformation; complexes containing bioactive ligands, as well as those that are differently charged, all experience a different reaction mechanism compared with cisplatin. Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli.
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Jin, Suxing, Yan Guo, Zijian Guo, and Xiaoyong Wang. "Monofunctional Platinum(II) Anticancer Agents." Pharmaceuticals 14, no. 2 (February 7, 2021): 133. http://dx.doi.org/10.3390/ph14020133.

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Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs. Among multifarious designs, monofunctional platinum(II) complexes with a general formula of [Pt(3A)Cl]+ (A: Ammonia or amine) stand out as a class of “non-traditional” anticancer agents hopeful to overcome the defects of current platinum drugs. This review aims to summarize the development of monofunctional platinum(II) complexes in recent years. They are classified into four categories: fluorescent complexes, photoactive complexes, targeted complexes, and miscellaneous complexes. The intention behind the designs is either to visualize the cellular distribution, or to reduce the side effects, or to improve the tumor selectivity, or inhibit the cancer cells through non-DNA targets. The information provided by this review may inspire researchers to conceive more innovative complexes with potent efficacy to shake off the drawbacks of platinum anticancer drugs.
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Stadnichenko, Raisa, Brian T. Sterenberg, Arlene M. Bradford, Michael C. Jennings, and Richard J. Puddephatt. "Platinum–thallium cluster complexes." Journal of the Chemical Society, Dalton Transactions, no. 6 (February 13, 2002): 1212–16. http://dx.doi.org/10.1039/b107579a.

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Vicente, José, Aurelia Arcas, Jesús M. Fernández-Hernández, Gabriel Aullón, and Delia Bautista. "Acetonyl Platinum(II) Complexes†." Organometallics 26, no. 25 (December 2007): 6155–69. http://dx.doi.org/10.1021/om700665n.

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Ramachandran, Ravindranath, and Richard J. Puddephatt. "Platinum hydride cluster complexes." Inorganic Chemistry 32, no. 11 (May 1993): 2256–60. http://dx.doi.org/10.1021/ic00063a010.

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Dissertations / Theses on the topic "Platinum complexes"

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Wheate, Nial Joseph Chemistry Australian Defence Force Academy UNSW. "Platinum anti-cancer complexes." Awarded by:University of New South Wales - Australian Defence Force Academy. School of Chemistry, 2001. http://handle.unsw.edu.au/1959.4/38704.

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[Formulae and special characters can only be approximated here. Please see the pdf version of the Abstract for an accurate reproduction.] Several inert platinum complexes were synthesised: [(en)Pt([special character]-dpzm)2Pt(en)]4+, [{Pt(dien)}2[special character]-dpzm]4+, [{Pt(dien)}2[special character]-H2N-(CH2)6-NH2]4+, cis-[(NH3)2Pt([special character]--dpzm)2Pt(NH3)2]4+, trans-[Pt(NH3)2([special character]-dpzm)2]2+. Three active complexes, all with chloro ligands, were also synthesised: trans-[{Pt(NH3)Cl2}2[special character]-dpzm)], trans-[{Pt(NH3)2Cl}2[special character]-dpzm]2+ (di-Pt) and trans-[trans-{Pt(NH3)2Cl}2{trans-[Pt(NH3)2([special character]-dpzm)2]}]4+ (tri-Pt). 1H NMR established that multi-nuclear platinum complexes will preferentially associate in the DNA minor groove with a preference for A/T sequences, and with a binding constant [special character]-105 M-1, regardless of the charge, linking ligand, length or shape. Using [(en)Pt([special character]-dpzm)2Pt(en)]4+ and the oligonucleotide d(GC)5 it was determined that the metal complex binds G/C rich sequences also in the minor groove, but with a much reduced binding constant, 103 M-1. CD studies showed [(en)Pt([special character]-dpzm)2Pt(en)]4+ was able to induce a DNA conformation change from B-type to what appeared to be a partial Z-type. Transcription assays showed that even though the metal complex does not bind DNA covalently, it is still able to inhibit DNA transcription at particular sites. The complexes di-Pt, tri-Pt, [{Pt(dien)}2[special character]-dpzm]4+ and trans-[Pt(NH3)2([special character]-dpzm)2]2+ were tested for anti-cancer activity in the L1210 murine leukaemia cell line, and gave values of 3.8, 2.5, [special character]200 and 64 [special character]M respectively. In the cisplatin resistant line (L1210/DDP), trans-[Pt(NH3)2([special character]-dpzm)2]2+ showed an increase in activity with a drop to 32 [special character]M, while both di-Pt and tri-Pt showed decreases in activity to values of 8.8 and 3.6 [special character]M. In the human ovarian carcinoma 2008 cell line and its cisplatin resistant derivative C13[special character]5, both complexes showed good activity with values of 2.5 and 20.9 [special character]M respectively, but again both showed decreases in activity in the resistant line with values of 17.8 and 37.7 [special character]M respectively. To help explain the difference between activity of these complexes and the complexes BBR3464 and BBR3005, cell uptake and DNA interstrand cross-linking experiments were performed. The cell uptake studies showed that both di-Pt and tri-Pt are taken up by cells at very high levels, when administered at 100 [special character]M, thus indicating that the difference is unlikely to be due to large differences in cell uptake. The DNA interstrand cross-linking studies showed both complexes readily form interstrand adducts (50% interstrand cross-linking at 12 nM and 22 nM respectively, c.f cisplatin 3 [special character]M). These results suggest that the rigid nature of the dpzm linker may be affecting the DNA adducts formed, with more interstrand links being formed than BBR3464. Possibly, it is this that causes the large differences in cytotoxicity. The DNA binding of di-Pt and tri-Pt was examined with the nucleosides adenosine and guanosine and the dinucleotide d(GpG). Both complexes bound at the N7 of guanosine, but 2-fold slower than cisplatin. In addition, di-Pt bound at the N7 and either the N1 or N3 of adenosine, 7-fold slower than guanosine. Di-Pt forms a large variety of cross-links between two d(GpG) molecules, however it could not be established whether the 1,2-intrastrand adduct could be formed. Di-Pt, however, forms a 1,2-GG interstrand adduct with the oligonucleotide d(ATGCAT)2 resulting in a conformation change away from B-type DNA. The sugar pucker of the G3 nucleoside changes from 2[special character]-endo towards 3[special character]-endo, and the position of the nucleotide relative to the sugar changes from anti to syn. The ability of multi-nuclear platinum complexes to form covalent adducts in the DNA minor groove remains unclear. It appears that di-Pt can form up to 33% minor groove adducts with the oligonucleotide d(AT)5, but when added to the oligonucleotide d(GCCAAATTTCCG)2 no definite minor groove adducts are seen and the major adduct appears to be a 1,2-interstrand cross-link between the two A6's or between the G1 and G11. Finally, a study of the encapsulation of platinum complexes within cucurbit[7]uril (Q7) as a means of reducing drug toxicity was made. For complex A and di-Pt, encapsulation of the linker ligand occurred. The effect of Q7 on the rate of hydrolysis of di-Pt was at least a 3-fold reduction as compared to free di-Pt with guanosine. Studies with [{Pt(dien)}2[special character]-dpzm]4+/Q7 and the oligonucleotide d(CGCGAATTCGCG)2 showed that the metal complex could dissociate from the Q7 and associate with the oligonucleotide, where an equilibrium is achieved with 15 % of the metal complex bound to the oligonucleotide and 75 % encapsulated in Q7. Tests in the L1210 and L1210/DDP cancer cell lines showed that di-Pt/Q7 has almost the same activity compared to free di-Pt.
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McGowan, Geraldine. "Platinum picoline anticancer complexes." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/11119.

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The 2-picoline (2-methylpyridine) complex, cis-[PtCl2(NH3)(2-pic)] (AMD473), is promising new generation platinum antitumour agent currently in clinical trials and highly active cisplatin resistant cell-lines. The antitumour activity of trans platinum complexes has attracted renewed interest since it has been shown that some trans compounds, in particular those possessing planar amine ligands, are anticancer-active. Therefore, three trans isomers, trans-[PtCl2(NH­3)(2-pic)] (1), trans-[PtCl2(NH3)(3-pic)] (2) and trans-[PtCl2(NH3)(4-pic)] (3), were synthesised and characterised. The crystal structure of 1 shows steric hindrance induced by the 2-methyl group towards an axial approach to Pt, while its 3-pic (2) and 4-pic (3) analogues are less sterically hindered. Notable however, is that in the solid state complex 1 is less sterically-hindered than its cis isomer. 15N-labelling of complexes 1-3 allowed both the hydrolysis rates and pKa values of the complexes to be determined using 2D[1H, 15N] NMR spectroscopy. Adducts of cis- and trans-(PtCl2(NH3)(2-pic)] with neutral 9-ethylguanine (9-EtGH) and anionic (N1-deprotonated) 9-ethylguanine (9-EtG) were prepared and their structures determined by X-ray crystallography. Platinum is coordinated at the guanine N7 position with a head-to-tail arrangement of the bases in all cases. Two of the complexes exhibited intermolecular triple hydrogen bonding between neutral and deprotonated guanine ligands. In addition, adducts of cis- and trans-[PtCl­2(NH3)(2-pic)] with guanosine and 2’-deoxyguanosine were prepared and characterised in solution by NMR spectroscopy and ESI mass spectrometry. The complexes cis-[Pt(NH3)(2-pic)(Guo)2]2+, and cis- and trans-(Pt(NH3)(2-pic)(2’-dGuo)2]2+ were assigned as head-to-tail conformations, on the basis of their NOE cross-peaks. The reaction of cis-[Pt(15NH3)(2-pic)(OH2)2]2+ and guanosine (Guo) was followed by 2D [1H, 15N] NMR spectroscopy and was found to proceed through two mono(guanosine) intermediate species to yield the dominant product cis-[Pt(15NH3)(2-pic)(Guo)2]2+. Initial guanosine substitution trans to 2-picoline was faster than substitution cis to 2-picoline due to steric hindrance, but the rates of the second guanosine substitution were similar. The binding of 15N-labelled-1 to a self-complementary DNA duplex, d(TATGGTACCATA)2, was investigated using 1D 1H and 2D [1H, 15H] NMR spectroscopy. The first aquation step appeared to be the rate-limiting step in the formation of the monofunctional adducts. Several DNA products were observed but could not be identified unambiguously. The rate constants for reactions between 15N-laabelled 1 and guanosine 5’-monophosphate (5’-GMP) were determined via 2D NMR studies, and compared to those previously reported for cis-[PtCl2(NH3)(2-pic)].
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Davies, Sian E. "Novel platinum (O) complexes." Thesis, University of Sussex, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335049.

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Hindmarsh, Kathryn. "Kinetic studies of platinum complexes." Thesis, University of Canterbury. Chemistry, 1998. http://hdl.handle.net/10092/8647.

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Since the chance discovery, in 1967, of the anti-tumour activity of cisplatin, cis-dichlorodiammineplatinum(II), research has focussed on studying the reactions of this and other related complexes in an effort to elucidate the nature of the biological activity. This thesis presents a study of the aqueous solution chemistry of some platinum(II) and platinum(IV) complexes in order to extend what is known about the simple chemistry of this biologically important class of compounds. The chloride ion anation of diaqua (cis-[Pt(OH₂)₂(N)₂]²⁺) complexes is investigated as is the bromide ion anation of the bromoaqua (cis-[PtBr(OH₂)(N)₂]⁺) and diaqua (cis-[Pt(OH₂)₂(N)₂]²⁺) species, all in 1.0 M HC1O₄. The kinetics are studied using UV/Vis spectroscopic methods - both conventional and stopped-flow. High-pressure stopped-flow is used for selected reactions to determine the effect of pressure on the anation process. The collective data are used to calculate activation parameters from which conclusions are drawn as to the mechanism of the reaction. The redox kinetics of the platinum(II)/platinum(IV) couple are investigated using a variety of redox agents. These data provide a basis on which to form mechanistic interpretations for both the oxidation and reduction processes. Extrapolations are made to the biological system for the reduction of anti-tumour active platinum(IV) drugs. Platinum(IV) complexes are known to be very inert. An investigation into the base hydrolysis of platinum(IV) complexes is presented and a mechanism proposed.
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Mackay, Fiona S. "Photoactive platinum azide anticancer complexes." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/11085.

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Photoactive platinum compounds have the potential to reduce some of the debilitating side-effects associated with conventional chemotherapeutics, such as cisplatin. Stable, inert platinum(IV) compounds which are reduced to active platinum(II) species only upon irradiation, could provide a site-specific treatment. The PtIV azide complexes, cis, trans, cis-[Pt(N3)2(OH)2(NH3)2] and cis, trans-[Pt(en)(N3)2, have previously been shown to be stable in the dark but reduced to PtII upon irradiation. The synthesis and characterisation of new platinum azide compounds, designed to improve important properties such as solubility and wavelength of absorbance are described here. Complexes which have azide ligands in a trans position were synthesised, the general formula is trans, trans, trans-[Pt(N3)2(OH)2(NH3)R] where R is NH3, pyridine, methylamine, ethylamine, thiazole, 2-picoline, 3-picoline, 4-picoline or cyclohexylamine. Several PtIV diazido compounds containing chelating aromatic ligands, such as 2,2’-bipyridine and 1,10-phenanthroline were also prepared. Many of the novel compounds synthesised were characterised by X-ray structure determination. The complexes with trans azides generally showed improved water solubility as well as a shift of the main absorbance band towards the visible region, compared to their cis analogues. A transcription mapping study of a fragment of pSP73KB plasmid DNA treated with cis, trans-[Pt(en)(N3)2(OH)2] and visible light, has shown that platination mainly occurs at consecutive guanine bases. The major binding sites were similar to those of cisplatin. No platination was seen in an identical sample which was not irradiated.
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Shaili, Evyenia. "Photoactivatable platinum (IV) anticancer complexes." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/59800/.

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In this work, trans-diazido Pt(IV) complexes with general formula [Pt(N3)2(OH)(OCOR)(pyr)2] (where OCOR is a carboxylate axial ligand) and [Pt(N3)2(OH)2(L1)(L2)] (where L1 and L2 are aromatic N-heterocyclic ligands) have been synthesised and characterised. The chemical and photochemical properties of these complexes, as well as their photobiological behaviour, have been studied in order to check their potential as photoactivatable anticancer drugs. Four trans-diazido Pt(IV) complexes with general formula trans, trans, trans- [Pt(N3)2(OH)(OCOR)(pyr)2] (OCOR= succinate, 4-oxo-4-propoxybutanoate, Nmethylisatoate and succinate-(RGD)f peptide ligands) have been obtained by axial derivatisation of one hydroxido ligand from trans, trans, trans- [Pt(N3)2(OH)2(pyr)2]. The crystal structures of three axially-derivatised complexes have been determined by X-ray diffraction. Photoirradiation studies have shown an improved photoactivity of the carboxylate versus the dihydroxido complexes at the longer wavelengths. Release of the axial ligands was observed in the studied complexes. This fact is especially relevant in the case of the Pt(IV)-(cRGD)f complex, where the RGD was incorporated as a tumour cell targeting moiety. DFT-TDDFT calculations performed on the complex trans, trans, trans- [Pt(N3)2(OH)(Succ)(pyr)2] showed dissociative transitions at longer wavelength, which could explain the photolability observed in these carboxylate derivatives. Studies of photoactivation of the diazido Pt(IV) complexes in the presence of 5’- GMP indicate the formation of a mono-GMP Pt(II) adduct as main photoproduct, therefore DNA could be considered a potential target site for these anticancer compounds. Additionally, EPR studies showed that azidyl radical release was observed when complexes bearing the succinate and 4-oxo-4-propoxybutanoate ligands were irradiated with green light. No such result was obtained for the dihydroxo precursor showing that these complexes could be phototoxic with longer wavelength light activation. Seven trans-diazido Pt(IV) complexes, trans, trans, trans- [Pt(N3)2(OH)2(L1)(L2)] (where L1 and L2 are pyridine, 2-picoline, 3-picoline, 4- picoline, thiazole or 1-methylimidazole ligands), have been obtained by oxidation of the corresponding trans-[Pt(N3)2(L1)(L2)] precursor. The X-ray crystal structures have been determined for four Pt(IV) diazido complexes from this family of compounds. Photoirradiation studies indicate that the incorporation of a sterically demanding ligand, e.g. trans, trans, trans-[Pt(N3)2(OH)2(2-pic)(pyr)], greatly enhances the photoactivity in these complexes. DFT-TDDFT calculations are in agreement with these results, since higher intensity transitions were observed for such complex at longer wavelength. Phototoxicity studies carried out on A2780, A2780cis and OE19 cell lines with the trans, trans, trans-[Pt(N3)2(OH)2(pyridine)(n-picoline)] family concluded that steric hindrance close to the platinum centre does not favour phototoxicity. Most of the complexes were equally potent in cisplatin resistance against the ovarian cancer cell line (A2780cis), except [Pt(N3)2(OH)2(3-pic)2] and [Pt(N3)2(OH)2(4-pic)2] which exhibited some cross resistance. All of the complexes tested in both OE19 and A2780 cell lines have shown less sensitivity to OE19 than to A2780. Studies in S. pombe yeast strains (WT and ΔRad3) with trans, trans, trans-[Pt(N3)2(OH)2(pyr)2] suggest that DNA is potentially an important target for this type of compounds, although other targets are not excluded. Furthermore, live-cell confocal microscopy was performed on A2780 cells treated with the complex trans, trans, trans-[Pt(N3)2(OH)2(pyr)2] and irradiated with a low dose of blue light. The cell death, monitored by propidium iodide uptake, was captured occurring 2 h 30 min post activation.
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Chantson, Janine. "Platinum (II) complexes of heteroaromatic derivatives." Pretoria : [s.n.], 2002. http://upetd.up.ac.za/thesis/available/etd-08012005-143742/.

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Aliprandi, Alessandro. "Platinum complexes and their luminescent assemblies." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF041/document.

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Cette thèse porte sur la synthèse et la caractérisation photophysique d'une série de composés neutres luminescents de platine (II) contenant un ligand tridentate dianionique chromophore N-donneur et un ligand auxiliaire monodentate. Les composés montrent un changement notable des propriétés de photoluminescence selon l'auto-assemblage en raison de la formation d'interactions intermoléculaires non covalentes faibles telles que metal-metal et π-π. Nous avons démontré comment les complexes de Pt (II) peuvent être auto-assemblés d'une manière contrôlée et précise en jouant sur les facteurs cinétiques et thermodynamiques, ainsi que la morphologie des différents ensembles étudiés. Ces approches ont conduit à des matériaux avec des propriétés améliorées et uniques tels que le mécano-chromisme, ainsi que l'absorption et l'émission de la lumière polarisée. Les composés étudiés et leurs assemblages sont utiles non seulement pour le développement de nouveaux matériaux fonctionnels supramoléculaires en équilibre et hors- équilibre, mais aussi pour des applications en bio-imagerie
This thesis focuses on the synthesis and the photophysical characterization of a series of luminescent neutral Pt(II) compounds containing a tridentate dianionic N-donor chromophoric ligand and a monodentate ancillary moiety. The compounds exhibited notable change of the photoluminescence properties upon self-assembly due to the establishment of weak non-covalent intermolecular interactions – metal-metal and π-π. We demonstrated how Pt(II) complexes can be self-assembled in a controlled and precise manner by playing with kinetic and thermodynamic factors and the morphology of the different assemblies investigated. Such approaches led to materials with enhanced and unique properties such as mechanochromism and polarized light absorption and emission. The investigated compounds and their assemblies were useful for the development of novel functional supramolecular materials in and out of the equilibrium as well as for bioimaging application
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Moulding, R. P. "Bis(diphenylphosphino)methane complexes of platinum." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375283.

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Farley, Sarah J. "Platinum complexes as potential photochemotherapeutic agents." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/3769.

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A major challenge of platinum anticancer therapy lies in overcoming the severe side-effects associated with treatment. Photoactivatable PtIV azido complexes, which are stable in the dark and reduced to cytotoxic PtII species upon irradiation, have recently emerged as a potential site-specific treatment. This thesis is concerned with the investigation of PtII and PtIV azido complexes as potential cytotoxic and photochemotherapeutic agents. PtII azido complexes such as [Pt(en)(N3)2] were shown to bind to both 5'-guanosine monophosphate (5'-GMP) and glutathione, at a much reduced rate compared with their PtII chlorido analogues. Interestingly, and unexpectedly, these PtII azido complexes showed moderate cytotoxicity towards the A2780 cancer cell line (IC50 21–47 μM). Binding to 5'-GMP was observed to occur more rapidly upon irradiation with UVA light, although the extent of binding was low and the complexes did not demonstrate phototoxicity towards HaCaT keratinocytes. The pendant hydroxyl group of a PtII azido complex was functionalised with a fluorescent probe; conjugation to one axial hydroxyl ligand of a PtIV azido complex was also achieved. The latter conjugate showed a rapid increase in fluorescence intensity upon irradiation, resulting from loss of the axial ligands upon photoreduction. The functionalisation of quantum dots with PtII complexes was also investigated. Water soluble CdSe-ZnS quantum dots were synthesised and derivatised with an amine ligand to which platinum was bound. Conjugation of apo-transferrin to quantum dots was also achieved, with subsequent platinum binding yielding a conjugate with improved aqueous solubility and fluorescence properties. However, the conjugate was inactive towards the A2780 cancer cell line, likely due to surface modifications preventing cellular internalisation. PtII chlorido and azido conjugates with a porphyrin were synthesised and found to show differing behaviour upon irradiation with visible light; evidence of hydrogen peroxide generation from the chlorido complex was much reduced in the case of the azido complex; it is suggested this may result from quenching of reactive oxygen species by the azide anion released upon irradiation. PtII chlorido and azido complexes of highly coloured azo ligands were synthesised in an attempt to shift the wavelength of activation into the visible region. TD-DFT calculations allowed frontier orbital analysis and assignment of the transitions in the absorption spectra. Irradiation of the PtII azido complexes with UVA or broadband visible light led to their decomposition; one water-soluble complex was found to show moderate cytotoxicity and phototoxicity; in addition, its intense blue colour allowed for visual monitoring of this complex inside cells.
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Books on the topic "Platinum complexes"

1

Cave, Gareth W. V. Cyclometalation: 2,6-diphenylpyridine complexes of platinum. [s.l.]: typescript, 1999.

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Quyoum, Ruhksana. Pentamethylclopentadienyl complexes of platinum(II): Their synthesis and reactivity. Salford: University of Salford, 1992.

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Baulieu, Etienne, Donald T. Forman, Magnus Ingelman-Sundberg, Lothar Jaenicke, John A. Kellen, Yoshitaka Nagai, Georg F. Springer, Lothar Träger, Liane Will-Shahab, and James L. Wittliff, eds. Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74760-1.

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E, Alessio, Clarke M. J, Società chimica italiana, Università degli studi di Trieste., and Symposium on Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy., eds. Ruthenium and other non-platinum metal complexes in cancer chemotherapy. Berlin: Spriger Verlag, 1989.

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Campbell, Colm J. Synthesis and study of platinum(II) and platinum(IV) complexes of EDTA derivatives as potential antitumour agents. Dublin: University College Dublin, 1996.

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Perera10010, A. D. S. The binding of platinum anti-tumour complexes to plasma proteins using 195mpt as a radiolabel and the synthesis and investigation of platinum complexes containing sulphide. Manchester: UMIST, 1989.

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Zou, Taotao. Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II). Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0657-9.

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Sutaria, Adil Dinyar. The effect of heterodentate chelatin P-N ligands on allyl and alkyl complexes of palladium and platinum. Salford: University of Salford, 1995.

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Elena, Soriano, José Marco-Contelles, and B. Alcaide. Computational mechanisms of Au and Pt catalyzed reactions. Heidelberg: Springer, 2011.

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Wehman-Ooyevaar, Ingrid C. M. Organometallic complexes of rhodium, iridium and platinum: Steric and electronic effects of chelating nitrogen ligands ... : proefschrift ter verkrijging van de graad van doctor ... 1992. Utrecht: [Rijksuniversiteit te Utrecht?], 1992.

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Book chapters on the topic "Platinum complexes"

1

Bosman, Irina, and Ganna V. Kalayda. "Platinum Complexes." In Encyclopedia of Cancer, 1–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_4616-2.

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Kelland, Lloyd R. "Platinum Complexes." In Cancer Therapeutics, 93–112. Totowa, NJ: Humana Press, 1997. http://dx.doi.org/10.1007/978-1-59259-717-8_4.

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Bosman, Irina, and Ganna V. Kalayda. "Platinum Complexes." In Encyclopedia of Cancer, 3606–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-46875-3_4616.

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Buss, Irina, and Ulrich Jaehde. "Platinum Complexes." In Encyclopedia of Cancer, 2911–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_4616.

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Blake, D. M., D. M. Roundhill, C. Ambridge, S. Dwight, and H. C. Clark. "Bis(Triphenylphosphine)Platinum Complexes." In Inorganic Syntheses, 120–24. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132494.ch19.

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Spencer, J. L., S. D. Ittel, and M. A. Cushing. "Olefin Complexes of Platinum." In Inorganic Syntheses, 213–18. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132500.ch49.

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Crascall, Louise E., John L. Spencer, Ruth Ann Doyle, and Robert J. Angelici. "Olefin Complexes of Platinum." In Inorganic Syntheses, 126–32. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132593.ch34.

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Phillips, Julia R., William C. Trogler, Mick Brammer, and Dianne L. Packett. "Chlorohydridobis(Trialkylphosphine)-Platinum(II) Complexes." In Inorganic Syntheses, 189–92. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132609.ch46.

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Adams, R. D., T. S. Barnard, J. E. Cortopassi, W. Wu, Z. Li, J. R. Shapley, and Kwangyeal Lee. "Platinum-ruthenium Carbonyl Cluster Complexes." In Inorganic Syntheses, 280–84. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470132630.ch44.

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Grice, Kyle A., Margaret L. Scheuermann, and Karen I. Goldberg. "Five-Coordinate Platinum(IV) Complexes." In Higher Oxidation State Organopalladium and Platinum Chemistry, 1–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17429-2_1.

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Conference papers on the topic "Platinum complexes"

1

Al-Khaykanee, Mohsin K., Faeq A. Al-Temimei, A. A. Al-Jobory, Dhay Ali Sabur, and Hamid I. Abbood. "Thermoelectric properties of platinum metal complexes." In THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5123090.

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Batchelor, Anna, Michael Duncan, Timothy Ward, and Joshua Marks. "INFRARED PHOTODISSOCIATION SPECTROSCOPY OF PLATINUM-CATION ACETYLENE COMPLEXES." In 2022 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2022. http://dx.doi.org/10.15278/isms.2022.mj11.

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Sortland, Miriam, Ryan Del Re, James Passarelli, Jodi Hotalen, Michaela Vockenhuber, Yasin Ekinci, Mark Neisser, Daniel Freedman, and Robert L. Brainard. "Positive-tone EUV resists: complexes of platinum and palladium." In SPIE Advanced Lithography, edited by Obert R. Wood and Eric M. Panning. SPIE, 2015. http://dx.doi.org/10.1117/12.2086598.

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Shpakovsky, D., T. Antonenko, R. Smirnov, Yu Gracheva, and E. Milaeva. "CYTOTOXIC ACTIVITY OF PLATINUM COMPLEXES CONTAINING THE ANTIOXIDANT MOIETY." In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-533.

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Petrović, Biljana. "TRANSITION METAL ION COMPLEXES AS POTENTIAL ANTITUMOR AGENTS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.009p.

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Abstract:
Discovery of the antitumor activity of platinum complex, cisplatin, cis-Pt(NH3)2Cl2, and later carboplatin and oxaliplatin, led to the intensive investigation of the potential antitumor activity of the huge number of platinum complexes. Furthermore, it is well-known that platinum complexes express toxicity, numerous side effects and resistance, so the scientists make a lot of efforts to synthetize, beside Pt(II) and Pt(IV), other non-platinum compounds with potential antitumor activity, such as Pd(II), Ru(II/III) and Au(III) complexes. The goal of this study is to summarize the results of the investigation of the interactions between some mononuclear, homo- and hetero-polynuclear Pt(II), Pd(II), Ru(II/III) and Au(III) complexes with different sulfur- and nitrogen-donor biologically relevant nucleophiles. Among mononuclear complexes, the compounds with aromatic terpy (tepyridine) or bpma (bis-(2- pyridylmethyl)amine) and aliphatic dien (diethylentriamine) nitrogen-containing inert ligands were studied. Different homo- and hetero-polynuclear complexes with pz (pyrazine) or 4,4’-bipy (4,4’- bipyridine) as bridging and mostly en (ethylenediamine), bipy (2,2’-bipyridine) and dach (trans-1,2- diaminocyclohexane) as inert ligands were studied as well. The research was focused on the connection between the structure and the mechanisms of interactions with different biomolecules, such as L- cysteine (L-Cys), L-methionine (L-Met), tripeptide glutathione (GSH), guanosine-5’-monophosphate (5’-GMP), DNA and bovine serum albumin (BSA). Some of these complexes were selected for in vitro studies of the cytotoxicity on different tumor cell lines. Observed results contribute a lot as a guidance for the future design and determination of the structure-activity relationship (SAR) of different transition metal ion complexes.
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Ohshima, Takuya, Yasuo Minami, Ikufumi Katayama, and Jun Takeda. "Broadband THz time-domain spectroscopy of halogen-bridged platinum complexes." In 2013 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR). IEEE, 2013. http://dx.doi.org/10.1109/cleopr.2013.6600522.

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Masek, Vlastimil, Peter Mojzes, Jan Palacky, Jiri Bok, Pavel Anzenbacher, P. M. Champion, and L. D. Ziegler. "Binding of Platinum Complexes to DNA Monitored by Raman Spectroscopy." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482591.

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Poloek, Anurach, Chin-Ti Chen, and Chao-Tsen Chen. "New platinum complexes for hybrid white organic light-emitting diodes." In SPIE Organic Photonics + Electronics, edited by Franky So and Chihaya Adachi. SPIE, 2013. http://dx.doi.org/10.1117/12.2022583.

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Chulkova, T., O. Agafonov, A. Afanasenko, N. Cherepanova, R. Khabibullin, and A. Legin. "C,N-CHELATED DIAMINOCARBENE PLATINUM COMPLEXES, A NEW CHEMICAL SPACE FOR THE DEVELOPMENT OF PLATINUM-BASED ANTICANCER DRUGS." In MedChem-Russia 2021. Издательство Волгоградского государственного медицинского университета, 2022. http://dx.doi.org/10.19163/medchemrussia2021-2022-11.

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Piovesan, Erick, Leonardo De Boni, and Cleber Renato Mendonça. "Nonlinear Optical Properties of Phenyl Diphenylamine Derivatives and Platinum Acetylide Complexes." In Latin America Optics and Photonics Conference. Washington, D.C.: OSA, 2010. http://dx.doi.org/10.1364/laop.2010.we11.

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Reports on the topic "Platinum complexes"

1

Ratilla, E. Platinum(II) complexes as spectroscopic probes for biomolecules. Office of Scientific and Technical Information (OSTI), September 1990. http://dx.doi.org/10.2172/6491206.

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Pham, Eric K., and Robert West. Platinum Eta 2 -Disilene Complexes: Syntheses, Reactivity, and Structures. Fort Belvoir, VA: Defense Technical Information Center, January 1990. http://dx.doi.org/10.21236/ada267080.

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Wei, X., R. J. Donohoe, W. Z. Wang, A. R. Bishop, and J. T. Gammel. Quantum Spin Fluctuations in Quasi-One-Dimensional Chlorine-Bridged Platinum Complexes. Office of Scientific and Technical Information (OSTI), January 1997. http://dx.doi.org/10.2172/618159.

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Zhou, Xia-Ying. Effects of ancillary ligands on selectivity of protein labeling with platinum(II) chloro complexes. Office of Scientific and Technical Information (OSTI), February 1990. http://dx.doi.org/10.2172/6941351.

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Eisenberg, R. Photochemistry of dithiolate complexes of the platinum group elements. Progress report, May 1, 1993--April 30, 1994. Office of Scientific and Technical Information (OSTI), January 1994. http://dx.doi.org/10.2172/10141031.

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Arias, Eduardo, Ivana Moggio, and Ronald Ziolo. Liquid Crystals of Dendron-Like Pt Complexes Processable Into Nanofilms Dendrimers. Phase 2. Cholesteric Liquid Crystal Glass Platinum Acetylides. Fort Belvoir, VA: Defense Technical Information Center, August 2014. http://dx.doi.org/10.21236/ada619975.

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Hulbert, L. Serra da Onça Complex, Pará State, Brazil: assessment of platinum-group element potential. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1998. http://dx.doi.org/10.4095/209924.

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Brugmann, G. E., and A. J. Naldrett. Origin of Copper - Nickel - Platinum Group Element Mineralization in the Ultramafic Part of the Lac Des Iles Complex, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1990. http://dx.doi.org/10.4095/131267.

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Seshadri, Ram. Platinum Group Metal (PGM) Substituted Complex Oxide Catalysts: Design of Robust Materials for Energy-Related Redox Transformations-Final Technical Report. Office of Scientific and Technical Information (OSTI), January 2014. http://dx.doi.org/10.2172/1120568.

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Brugmann, G. E., and A. J. Naldrett. Vapour - Induced Partial Melting in the Gabbroic Part of the Lac Des Iles Complex, Ontario and the Genesis of Platinum Group Element Mineralization. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1990. http://dx.doi.org/10.4095/131266.

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