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1

White, Melanie McCabe. Platelet protocols: Research and clinical laboratory procedures. San Diego: Academic Press, 1999.

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2

1951-, Parnham Michael J., and Prop Gerrit, eds. Cologne Atherosclerosis Conference, Nr. 3, platelets. Basel: Birkhäuser, 1986.

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3

El-Nageh, Nuria Mabrouk. Studies on the mechanism of inhibition of blood platelet aggregation by pyridoxal-5'-phosphate. Dublin: University College Dublin, 1996.

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4

1932-, Oates John A., Hawiger Jacek, and Ross Russell, eds. Interaction of platelets with the vessel wall. Bethesda, Md: American Physiological Society, 1985.

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5

Jacek, Hawiger, ed. Platelets: Receptors, adhesion, secretion. San Diego: Academic, 1989.

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6

D, Cohen Marc M., ed. Handbook of antiplatelet therapy. London: Martin Dunitz, 2003.

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7

D, Wiviott Stephen, and American Heart Association, eds. Antiplatelet therapy in ischemic heart disease. Chichester, West Sussex, UK: Wiley-Blackwell, 2009.

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8

Rhône-Poulenc Santé - INSERM Conference (1985 Menthon-Saint-Bernard). Biology and pathology of platelet-vessel wall interactions: Proceedings of the Rhône-Poulenc Santé - INSERM Conference, held at Menthon-Saint-Bernard (Annecy), France, September 30th to October 2nd, 1985. London: Academic Press, 1986.

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9

Rhône-Poulenc Round Table Conference (4th 1985 Menthon-Saint-Bernard, France). Biology and pathology of platelet-vessel wall interactions: Proceedings of the Rhône-Poulenc Santé-INSERM Conference, held at Menthon-Saint-Bernard (Annecy), France, September 30th to October 2nd, 1985. London: Academic Press, 1986.

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10

1943-, O'Flaherty Joseph T., Ramwell Peter W, and International Business Communications Inc, eds. PAF antagonists: New developments for clinical application. Woodlands, Tex: Portfolio Pub. Co., 1990.

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11

Handbook of compounds with anti-inflammatory and anti-platelet aggregation activities isolated from plants. New York: Nova Science Publishers, 2008.

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12

International Symposium on Medicinal Chemistry (14th 1996 Maastricht, Netherlands). XIVth International Symposium on Medicinal Chemistry: Maastricht, 8-12 September 1996. Amsterdam: Elsevier, 1997.

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13

International Symposium on Medicinal Chemistry (14th 1996 Maastricht, Netherlands). XIVth International Symposium on Medical Chemistry: Proceedings, Maastricht, 8-12 September 1996. Amsterdam: Elsevier, 1997.

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14

Antiplatelet therapy in ACS and A-Fib. Basel: Karger, 2012.

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15

Pharand, Chantal. The use of platelet glycoprotein IIB/IIIA receptor antagonists in the management of unstable angina and non-st-elevation myocardial infarction: A critical evaluation. [Toronto?: s.n., 2000.

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16

Cologne Atherosclerosis Conference (3rd 1986). Cologne Atherosclerosis Conference, No. 3, platelets: 3rd Cologne Atherosclerosis Conference, Cologne, April 23-25, 1986. Basel: Birkhäuser, 1986.

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17

A, Mousa Shaker, ed. Anticoagulants, antiplatelets, and thrombolytics. Totowa, N.J: Humana Press, 2004.

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18

Clopidogrel response in acute coronary syndrome: Clinical implications and emerging therapies. Hauppauge, N.Y: Nova Science Publishers, 2010.

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19

E, Freedman Jane, and Loscalzo Joseph, eds. New therapeutic agents in thrombosis and thrombolysis. 3rd ed. New York: Informa Healthcare USA, 2009.

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20

Waksman, Ron, and Andrew E. Ajani. Pharmacology in the catheterization laboratory. Chichester, West Sussex, UK: Wiley-Blackwell, 2009.

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21

Anticoagulants, antiplatelets, and thrombolytics. 2nd ed. New York, NY: Humana, 2010.

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22

Bjorn, Neu, and Meiselman Herbert J, eds. Red blood cell aggregation. Boca Raton: CRC Press, 2012.

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23

Nolan, Marie-Louise. Studies on the effects of pyridoxal-5'-phosphate on the aggregation of blood platelets. Dublin: University College Dublin, 1997.

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24

A, FitzGerald G., and Patrono Carlo 1944-, eds. Platelets and vascular occlusion. New York: Raven Press, 1989.

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25

1929-, Hass William K., and Easton J. Donald, eds. Ticlopidine, platelets, and vascular disease. New York: Springer-Verlag, 1993.

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26

1946-, Missirlis Y. F., and Wautier J. -L, eds. The Role of platelets in blood-biomaterial interactions. Dordrecht: Kluwer, 1993.

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27

Ron, Waksman, and Ajani Andrew A. E, eds. Pharmacology in the catheterization laboratory. Chichester, West Sussex, UK: Wiley-Blackwell, 2009.

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28

White, Melanie McCabe, and Lisa K. Jennings. Platelet Protocols: Research and Clinical Laboratory Procedures. Elsevier Science & Technology Books, 1999.

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29

R, Born Gustav V., and Neri Serneri G. G, eds. Antiplatelet therapy: Twenty years' experience : proceedings of a European conference, Florence, 26-28 March 1987. Amsterdam: Excerpta Medica, 1987.

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30

Curry, Nicola, and Raza Alikhan. Normal platelet function. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0281.

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The platelet is a small (2–4 µm in diameter), discoid, anucleate cell that circulates in the blood. In health, it plays a vital role in haemostasis, and in disease it contributes to disorders of bleeding and thrombosis. Platelets are produced from the surface of megakaryocytes in the bone marrow, under tight homeostatic control regulated by the cytokine thrombopoietin. Platelets have a lifespan of approximately 7–10 days, and usually circulate in the blood stream in a quiescent state. Intact, undamaged vessel walls help to maintain platelets in this inactive state by releasing nitric oxide, which acts both to dilate the vessel wall and to inhibit platelet adhesion, activation, and aggregation. After trauma to the blood vessel wall, platelets are activated and, acting in concert with the endothelium and coagulation factors, form a stable clot. This chapter addresses platelet structure and function, and the response of platelets to vessel injury.
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31

Fuster, Valentin, Clive P. Page, Jos Vermylen, and Paolo Gresele. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2005.

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32

(Editor), Paolo Gresele, Clive P. Page (Editor), Valentin Fuster (Editor), and Jos Vermylen (Editor), eds. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2002.

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33

Fuster, Valentin, Clive P. Page, Jos Vermylen, and Paolo Gresele. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2002.

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34

Gresele, Paolo. Platelets in Thrombotic and Non-thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2002.

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35

Fuster, Valentin, Clive P. Page, Jos Vermylen, and Paolo Gresele. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2010.

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36

Fuster, Valentin, Clive P. Page, Jos Vermylen, and Paolo Gresele. Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics. Cambridge University Press, 2002.

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37

Mechanisms of StimulusResponse Coupling in Platelets. Springer, 1986.

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38

J, Westwick, ed. Mechanisms of stimulus-response coupling in platelets. New York: Plenum Press, 1985.

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39

Agnoli, A., and C. Fazio. Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders: Proceedings of the Round Table Conference. Rome, October 30 - 31 1974. Springer London, Limited, 2012.

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40

Agnoli, A., and C. Fazio. Platelet Aggregation in the Pathogenesis of Cerebrovascular Disorders: Proceedings of the Round Table Conference. Rome, October 30-31 1974. Springer, 2012.

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41

Dwyer, Scott Douglas. Effects of anesthetics, anticoagulants, and rat strain on rat platelet aggregation. 1985.

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42

Shen, Howard. MemoCharts Pharmacology: Platelet Aggregation, Blood Coagulation and Related Drugs (Review chart). Minireview, 2004.

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43

Wiviott, Stephen D. Antiplatelet Therapy in Ischemic Heart Disease. Wiley & Sons, Limited, John, 2009.

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44

Menthon-Saint-Bernard, fran Rhone-Poulenc Round Table Conference 1985, Y. L. Legrand, G. Jolles, and Institut National De LA Sante Et De LA Recherche Medicale (France). Biology and Pathology of Platelet-Vessel Wall Interactions: Proceedings of the Rhone-Poulenc Sante-Inserm Conference, Held at Menthon-Saint-Bernard (Annecy), ... France, September 30th to October 2nd, 1985. Academic Press, 1988.

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45

Menthon-Saint-Bernard, fran Rhone-Poulenc Round Table Conference 1985, Y. L. Legrand, G. Jolles, and Institut National De LA Sante Et De LA Recherche Medicale (France). Biology and Pathology of Platelet-Vessel Wall Interactions: Proceedings of the Rhone-Poulenc Sante-Inserm Conference, Held at Menthon-Saint-Bernard (Annecy), ... France, September 30th to October 2nd, 1985. Academic Press, 1988.

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46

O'Flaherty, Joseph T., and Peter W. Ramwell. Paf Antagonists: New Developments for Clinical Application (Advances in Applied Biotechnology Series, Vol 9). Portfolio Pub Co, 1991.

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47

Ruggeri, Z. M. Von Willebrand Factor And The Mechanisms Of Platelet Function (Biotechnology Intelligence Unit). Edited by Z. M. Ruggeri. Springer, 1998.

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48

Kuiper, Gerhardus J. A. J. M., and Hugo ten Cate. Coagulation monitoring. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0266.

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Haemostasis is a dynamic process to stop bleeding after vessel wall damage. Platelets form a platelet plug via activation, adherence, and aggregation processes. The coagulation proteins are activated one-by-one, cascading towards fibrin polymerization, a process controlled by thrombin generation. Fibrinolysis is the process responsible for fibrin mesh degradation, which is also controlled by thrombin. Besides procoagulant proteins, anticoagulant proteins maintain a balance in the haemostatic system. Measuring platelet count and function can be done as part of the monitoring of haemostasis, while coagulation times are measured to assess the coagulation proteins. Degradation products of fibrin and lysis times give information about fibrinolysis. Point-of-care monitoring provides simple, rapid bedside testing for platelets and for whole blood using viscoelasticity properties. In trauma-induced coagulopathy (TIC) platelet counts and coagulation times are still common practice to evaluate haemostasis, but point-of-care measurements are being used more and more. Medication interfering with haemostasis is frequently used in intensive care unit patients. Each (group of) drug(s) has its own monitoring tests either based on classical or novel techniques.
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49

Pruthi, Rajiv K. Coagulation (Hemostasis and Thrombosis). Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0295.

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The coagulation system has 2 essential functions: to maintain hemostasis and to prevent and limit thrombosis. The procoagulant component of the hemostatic system prevents and controls hemorrhage. Vascular injury results in activation of hemostasis, which consists of vasospasm, platelet plug formation (platelet activation, adhesion, and aggregation), and fibrin clot formation (by activation of coagulation factors in the procoagulant system). The anticoagulant system prevents excessive formation of blood clots, and the fibrinolytic system breaks down and remodels blood clots. Quantitative abnormalities (deficiencies) and qualitative abnormalities of platelets and coagulation factors lead to bleeding disorders, whereas deficiencies of the anticoagulant system are risk factors for thrombosis. Common disorders of hemostasis and thrombosis are reviewed.
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50

Michael, Lincoff A., and Topol Eric J. 1954-, eds. Platelet glycoprotein IIb/IIIa receptor inhibitors in cardiovascular disease. Totowa, N.J: Humana Press, 1999.

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