Academic literature on the topic 'Platelet activating factor'

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Journal articles on the topic "Platelet activating factor"

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Wimberly, H. C., D. O. Slauson, and N. R. Neilsen. "Functional and Biochemical Characterization of Immunologically Derived Equine Platelet-Activating Factor." Veterinary Pathology 22, no. 4 (1985): 375–86. http://dx.doi.org/10.1177/030098588502200413.

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Antigen-specific challenge of equine leukocytes induced the non-lytic release of a platelet-activating factor in vitro. The equine platelet-activating factor stimulated the release of serotonin from equine platelets in a dose-responsive manner, independent of the presence of cyclo-oxygenase pathway inhibitors such as indomethacin. Rabbit platelets were also responsive to equine platelet-activating factor. The release of equine platelet-activating factor was a rapid reaction with near maximal secretion taking place in 30 seconds. Addition of equine platelet-activating factor to washed equine pl
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Zhou, W., M. A. Javors, and M. S. Olson. "Platelet-activating factor as an intercellular signal in neutrophil-dependent platelet activation." Journal of Immunology 149, no. 5 (1992): 1763–69. http://dx.doi.org/10.4049/jimmunol.149.5.1763.

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Abstract The role of platelet-activating factor (PAF) in heterotypic cell to cell interactions in a rabbit neutrophil-platelet mixture model was investigated. Platelets were exposed to each of three chemotactic agonists: PAF, leukotriene B4 (LTB4), or FMLP. Only PAF stimulated aggregation, [3H]serotonin secretion, and cytosolic Ca2+ mobilization in platelets alone. However, platelets were stimulated by LTB4 and FMLP in the presence of neutrophils. This neutrophil-dependent platelet activation was blocked by pretreatment of platelets with PAF receptor antagonists, and was prevented by desensiti
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Perry, Seth W., Jason A. Hamilton, Larry W. Tjoelker, et al. "Platelet-activating Factor Receptor Activation." Journal of Biological Chemistry 273, no. 28 (1998): 17660–64. http://dx.doi.org/10.1074/jbc.273.28.17660.

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Welch, Emily J., Ram P. Naikawadi, Zhenyu Li, et al. "Opposing Effects of Platelet-Activating Factor and Lyso-Platelet-Activating Factor on Neutrophil and Platelet Activation." Molecular Pharmacology 75, no. 1 (2008): 227–34. http://dx.doi.org/10.1124/mol.108.051003.

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KAWASAKI, Tomio, and Jun-ichi KAMBAYASHI. "Platelet-activating Factor." Japanese Journal of Thrombosis and Hemostasis 2, no. 4 (1991): 274–85. http://dx.doi.org/10.2491/jjsth.2.274.

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Kingsnorth, A. N. "Platelet-Activating Factor." Scandinavian Journal of Gastroenterology 31, sup219 (1996): 28–31. http://dx.doi.org/10.3109/00365529609104996.

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McCORMACK, DAVID G., PETER J. BARNES, and TIMOTHY W. EVANS. "Platelet-activating factor." Critical Care Medicine 18, no. 12 (1990): 1398–402. http://dx.doi.org/10.1097/00003246-199012000-00018.

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Martin, John. "PLATELET-ACTIVATING FACTOR." Lancet 332, no. 8626-8627 (1988): 1486. http://dx.doi.org/10.1016/s0140-6736(88)90956-7.

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Humphreys, Randy F. "PLATELET ACTIVATING FACTOR." Southern Medical Journal 83, Supplement (1990): 2S—2. http://dx.doi.org/10.1097/00007611-199009001-00004.

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Prescott, S. M., G. A. Zimmerman, and T. M. McIntyre. "Platelet-activating factor." Journal of Biological Chemistry 265, no. 29 (1990): 17381–84. http://dx.doi.org/10.1016/s0021-9258(18)38167-5.

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Dissertations / Theses on the topic "Platelet activating factor"

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Scarlett, Julie Anne. "Platelet activating factor in the horse." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387750.

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Murphy, Christine Therese. "Mechanisms of stimulus-response coupling in platelet-activating factor stimulated platelets." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304999.

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DENTAN, CHRISTINE. "Platelet-activating factor (paf), acetylhydrolase et atherosclerose." Paris 6, 1996. http://www.theses.fr/1996PA066772.

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L'atherosclerose est une pathologie des vaisseaux, multifactorielle, qui a un caractere immuno-inflammatoire chronique. Or, de plus en plus de donnees argumentent le role pro-atherogene et pro-thrombogene d'un puissant mediateur glycerophospholipidique, le platelet-activating factor (paf), qui est degrade specifiquement par l'acetylhydrolase. Cette hypothese est etayee par nos travaux qui ont mis en evidence la formation du paf dans un modele de cellules spumeuses, riches en esters de cholesterol, stimulees par phagocytose. Ces cellules, qui representent la principale composante cellulaire du
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Bonin, Fanny. "Cytoprotective effects of intracellular platelet activating factor acetylhydrolases." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26529.

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Platelet activating factor (PAF) is a biologically active phospholipid implicated in the developmental brain disorder Miller-Dieker Syndrome (MDS) and purported to be a primary mediator of cell death in HIV-dementia, ischemia, and epilepsy. As part of my honour's thesis, I demonstrated that PAF can elicit cell death independently of its G-protein coupled receptor (PAFR) in PC12 cells. In my M.Sc. research, I have sought to identify how PAF-mediated cell death is regulated in PC12 cells. PAF is inactivated in brain by two intracellular PAF-acetylhydrolases (PAF-AHs): PAF-AH I and PAF-AH II. PAF
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Gomez, Jorge. "Characterization and regulation of platelet activating factor receptors." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185248.

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Platelet activating factor (PAF) is a potent mediator in a variety of inflammatory events. Determining whether PAF participates in the bronchial hyperresponsiveness characteristic of asthma is the long term obj ecti ve for which the studies described here represent an initial step. PAF is a potent agonist that causes contraction of guinea pig peripheral lung strips. To determine if specific receptor sites for PAF could be demonstrated in guinea pig lung membranes (GPLM), direct radioligand binding studies were performed with [³H]C₁₆-PAF (l-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) and
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Vanags, Daina M. "Adrenergic and serotonergic potentiation of platelet aggregation /." Title page, summary and contents only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phv217.pdf.

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Kabbani, Nazir. "Chemical-genetic profiling of platelet-activating factor in yeast." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28189.

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The basic biological processes between the yeast Saccharomyces cerevisiae and mammals are highly conserved. Yeast posses many genes that are implicated in human diseases and have been successfully used as a model for the study of neurodegeneration. Platelet-Activating Factor (C16:0 PAF) causes neuronal cell death independent of its receptor and has been implicated in Alzheimer's disease. I hypothesized that yeast could be used as a model system for deciphering PAF receptor-independent signalling and have utilized genome-wide chemical genomic screening in yeast to further characterize the mole
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Rowe, Anna-Louise. "The role of platelet-activating factor in necrotising enterocolitis." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434713.

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Göggel, Rolf. "The mechanisms of platelet activating factor induced alterations in lung functions /." Konstanz : Hartung-Gorre, 2002. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009757517&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Bosnic, Anthony Martin. "Human antibody responses to a chlamydia-secreted protease factor : a thesis /." San Antonio : UTHSC, 2005. http://learningobjects.library.uthscsa.edu/cdm4/item%5Fviewer.php?CISOROOT=/theses&CISOPTR=14&REC=5.

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Books on the topic "Platelet activating factor"

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1946-, Barnes Peter J., Page C. P, and Henson P. M. 1940-, eds. Platelet activating factor and human disease. Blackwell Scientific, 1989.

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M, Winslow C., and Lee M. L, eds. New horizons in platelet activating factor research. Wiley, 1987.

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M, Winslow C., and Lee M. L, eds. New horizons in platelet activating factor research. Wiley, 1987.

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P, Braquet, ed. CRC handbook of PAF and PAF antagonists. CRC Press, 1991.

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Snyder, Fred, ed. Platelet-Activating Factor and Related Lipid Mediators. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5284-6.

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Fred, Snyder, ed. Platelet-activating factor and related lipid mediators. Plenum Press, 1987.

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K, Nigam S., Kunkel Gert, Prescott Stephen M, and International Congress on Platelet-Activating Factor and Related Lipid Mediators (1995 : Berlin, Germany), eds. Platelet-activating factor and related lipid mediators 2: Roles in health and disease. Plenum Press, 1996.

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Nigam, Santosh, Gert Kunkel, and Stephen M. Prescott, eds. Platelet-Activating Factor and Related Lipid Mediators 2. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0179-8.

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A, Handley Dean, ed. Platelet-activating factor in endotoxin and immune diseases. Dekker, 1990.

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Pharmacy), Symposium on Problems on PAF (11th 1987 Tohoku College of. Trends in pharmacological research on platelet activating factor (PAF) in Japan: Proceedings of the Symposium on Problems on PAF held at the Tohoku College of Pharmacy, Sendai, Japan, September 19th, 1987. Ishiyaku EuroAmerica, 1988.

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Book chapters on the topic "Platelet activating factor"

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Dent, Gordon. "Platelet-Activating Factor." In Airways Smooth Muscle: Neurotransmitters, Amines, Lipid Mediators and Signal Transduction. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7504-2_7.

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Schwab, Manfred. "Platelet-Activating-Factor." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_4609-2.

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Lopes-Martins, Rodrigo A. B., Claudia V. Araújo, Vanessa Estato, Sheila Moreira, Renato S. B. Cordeiro, and Eduardo V. Tibiriçá. "Platelet-Activating Factor." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0179-8_36.

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Salajegheh, Ali. "Platelet-Activating Factor." In Angiogenesis in Health, Disease and Malignancy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28140-7_39.

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Poeze, M., W. A. Buurman, G. Ramsay, and J. W. M. Greve. "Platelet-Activating Factor." In Multiple Organ Failure. Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4612-1222-5_22.

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Shukla, Shivendra D. "Platelet Activating Factor and Platelets." In Handbook of Platelet Physiology and Pharmacology. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-5049-5_6.

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Shimizu, Takao, Hiroyuki Mutoh, and Shigeaki Kato. "Platelet-Activating Factor Receptor." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0179-8_14.

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Marrache, A. Marilise, Fernand Gobeil, Sylvie G. Bernier, et al. "Platelet Activating Factor Receptors." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9194-2_33.

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O’Flaherty, Joseph T. "Platelet-Activating Factor: Mechanisms of Cellular Activation." In Platelet-Activating Factor and Related Lipid Mediators. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5284-6_13.

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Marathe, Gopal Kedihithlu, Shancy Petsel Jacob, Mosale Seetharam Sumanth, Chikkamenahalli Lakshminarayana Lakshmikanth, Kandahalli Venkataranganayaka Abhilash, and Vyala Hanumanthareddy Chaithra. "Platelet-Activating Factor Acetylhydrolase (Pafah)." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101737.

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Conference papers on the topic "Platelet activating factor"

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Ucci, Sarassunta, Anna Aliberti, Sara Spaziani, et al. "Platelet-rich plasma photo-activation: enhanced release of growth factors for improved regenerative medicine outcomes." In Mechanisms of Photobiomodulation Therapy XIX, edited by James D. Carroll, Ann Liebert, and Jeri-Anne Lyons. SPIE, 2025. https://doi.org/10.1117/12.3046039.

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Struk, A., A. Prins, M. C. L. Schaap, J. W. ten Cate, and H. van den Bosch. "SYNTHESIS OF PLATELET ACTIVATING FACTOR BY HUMAN BLOOD PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643486.

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Synthesis of platelet activating factor (PAF) by human blood platelets is a controversial issue. Whereas some groups have reported the synthesis, induced by thrombin, collagen or Ca2--ionophore Azsio?, others were unable to obtain for instance the thrombin-induced PAF synthesis. Also, synthesis of only up to 6 pMoles PAF/10 platelets has been reported, but leucocytes may synthesize up to 6000 pMoles PAF/10 cells. Only an 0.1% leucocyte contamination would thereby explain the “ platelet PAF synthesis” . We therefore optimized the PAF synthesis by human blood platelets and leucocytes, induced by
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Matsuno, K., F. Katabami, M. Koyama, et al. "PLATELET-ACTIVATING FACTOR (PAF)-INDUCED INTRACELLULAR Ca MOBILIZATION IN HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643483.

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PAF-induced intracellular Ca2+ mobilization and platelet aggregation were investigated in human platelets. Cytosolic free Ca2+ concentration ([Ca2+]cyt) was measured by using fluorescent 45Ca2+ probe quin2 and fura-2, and photoprotein aequorin. Ca2+ uptake was measured after stimulation by PAF. Platelet aggregation was studied by recording the change in light transmission with platelet rich plasma (PRP) or washed platelet suspension (WPS).These three Ca2+ -indicators could determine the elevation of [Ca2+ ]cyt that was stimulated by PAF in the presence of extra- cellular Ca2+ (quin2 method: 98
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Del Maschio, A., M. Albors, F. Bucchi, et al. "HUMAN POLYMORPHONUCLEAR LEUKOCYTE ACTIVATION INDUCED BY PLATELET ACTIVATING FACTOR (PAF)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643482.

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Human polymorphonuclear leukocytes (PMNs) loaded with the photoprotein Aequorin, were exposed to PAF in the presence of extracellular Ca2+ (1 mM). PMNs aggregation measured In the “Platelet Ionized Calcium Aggregometer” (P.I.C.A.) was dependent on the concentration of the stimulus. Ca2+ cytoplasmatic increase was monitored in parallel at concentrations of PAF which did not modify cellular integrity (10-7-10-5M). The intracellular Ca2+ flux (up to 19±3 µM) triggered by PAF was also concentration-dependent. In order to establish the role played by this intracellular messenger, we studied some ce
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Muntean, W., and B. Leschnik. "FACTOR VIII MEDIATES BINDING OF FACTOR IX TO STIMULATED PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644074.

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In previous work we have shown that factor VII! binds to phospholipids of the membrane of stimulated platelets and that von Willebrand factor is not required for binding of factor VIII to platelets. Since factor VIII is a cofactor in the activation of factor X by factor IX, we investigated whether factor VIII enhances binding of factor IX to the platelet surface.Factor VIII and factor IX were purified by immunoadsorbent chromatography using specific rabbit antibodies. Washed human platelets (250/nl final concentration) stimulated by human thrombin and collagen were incubated with barbiturate b
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Sturk, A., M. C. L. Schaap, A. Prins Heymans, et al. "SEVERELY IMPAIRED SYNTHESIS OF PLATELET ACTIVATING FACTOR IN CHONDRO DYSPLASIA PUNCTATA RHIZOMELIA PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642883.

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The first steps of the de novo synthesis of alkoxyether lipids, like plasmalogens and platelet activating factor (PAF) are localized in the peroxisome. We have previously reported the severely impaired PAF synthesis in Zellweger patients. These patients lack cytochemically detectable peroxisomes, and have a severely impaired alkoxyether lipid synthesis. However, chondro dysplasia punctata (CDP) patients have also been shown to have an impaired alkoxyether lipid synthesis. We therefore investigated PAF synthesis in CDP patients.Platelets and leucocytes were isolated from 3 CDP patients. Leucocy
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Chung, Chi-Li, Mei-Chuan Chen, Jie-Heng Tsai, and Cheng-Ying Hsieh. "Profibrotic implication of platelet-activating factor in tuberculous pleural effusion." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.3356.

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Miyashita, L., G. Foley, N. M. Liu, et al. "Airway Platelet-Activating Factor Receptor Expression Is Increased in Neonates." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1893.

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Miyashita, L., B. Coldwell, D. Wertheim, et al. "Sand Particles Increase Platelet-Activating Factor Receptor Expression In Vitro." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4422.

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COEFFIER, e., D. Delautier, J.-P. Le Couedic, M. Chinqnard, and J. Benveniste. "ACTIVATED HUMAN PLATELETS AND NEUTROPHILS COOPERATE FOR THE FORMATION OF PAF-ACETHER (PLATELET-ACTIVATING FACTOR)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642881.

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Interactions between platelets and neutrophils have been reported for the production of several mediators of inflammation such as hydrogen peroxides or leukotrienes. Another potential mediator of thrombosis and inflammation is paf-acether which is synthesized by activated platelets and neutrophils.Since platelets form and release large amounts of the paf-acether precursor lyso paf-acether, platelets and neutrophils cooperation for paf-acether biosynthesis was investigated. Purified human neutrophils (4 × 106 /ml) stimulated by opsonized zymosan (ZC, 1 mg/ml) formed 4.5 ± 2.5 ng/ml paf-acether.
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Reports on the topic "Platelet activating factor"

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Snyder, F. Regional Neonatal Associates for cooperative study of platelet-activating factor (PAF). Summary report. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/28403.

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