Academic literature on the topic 'Plasmalogen lipids'
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Journal articles on the topic "Plasmalogen lipids":
Rothhaar, Tatjana L., Sven Grösgen, Viola J. Haupenthal, Verena K. Burg, Benjamin Hundsdörfer, Janine Mett, Matthias Riemenschneider, Heike S. Grimm, Tobias Hartmann, and Marcus O. W. Grimm. "Plasmalogens Inhibit APP Processing by Directly Affectingγ-Secretase Activity in Alzheimer’s Disease." Scientific World Journal 2012 (2012): 1–15. http://dx.doi.org/10.1100/2012/141240.
Paul, Sudip, Aliki A. Rasmiena, Kevin Huynh, Adam Alexander T. Smith, Natalie A. Mellett, Karin Jandeleit-Dahm, Graeme I. Lancaster, and Peter J. Meikle. "Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice." Metabolites 11, no. 5 (May 6, 2021): 299. http://dx.doi.org/10.3390/metabo11050299.
Rüdiger, Mario, Angelika Tölle, Wolfgang Meier, and Bernd Rüstow. "Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity." American Journal of Physiology-Lung Cellular and Molecular Physiology 288, no. 2 (February 2005): L379—L383. http://dx.doi.org/10.1152/ajplung.00176.2004.
Bozelli, José Carlos, and Richard M. Epand. "Plasmalogen Replacement Therapy." Membranes 11, no. 11 (October 29, 2021): 838. http://dx.doi.org/10.3390/membranes11110838.
NAGAN, Narasimhan, Amiya K. HAJRA, Leslie K. LARKINS, Paul LAZAROW, Edward PURDUE, William B. RIZZO, and Raphael A. ZOELLER. "Isolation of a Chinese hamster fibroblast variant defective in dihydroxyacetonephosphate acyltransferase activity and plasmalogen biosynthesis: use of a novel two-step selection protocol." Biochemical Journal 332, no. 1 (May 15, 1998): 273–79. http://dx.doi.org/10.1042/bj3320273.
Werner, Ernst R., Markus A. Keller, Sabrina Sailer, Katharina Lackner, Jakob Koch, Martin Hermann, Stefan Coassin, et al. "TheTMEM189gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens." Proceedings of the National Academy of Sciences 117, no. 14 (March 24, 2020): 7792–98. http://dx.doi.org/10.1073/pnas.1917461117.
Gallego-García, Aránzazu, Antonio J. Monera-Girona, Elena Pajares-Martínez, Eva Bastida-Martínez, Ricardo Pérez-Castaño, Antonio A. Iniesta, Marta Fontes, S. Padmanabhan, and Montserrat Elías-Arnanz. "A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis." Science 366, no. 6461 (October 3, 2019): 128–32. http://dx.doi.org/10.1126/science.aay1436.
Theiss, Elena Leoni, Lea Victoria Griebsch, Anna Andrea Lauer, Daniel Janitschke, Vincent Konrad Johannes Erhardt, Elodie Christiane Haas, Konstantin Nicolas Kuppler, et al. "Vitamin B12 Attenuates Changes in Phospholipid Levels Related to Oxidative Stress in SH-SY5Y Cells." Cells 11, no. 16 (August 18, 2022): 2574. http://dx.doi.org/10.3390/cells11162574.
Perez, Marcos A., Andrea J. Clostio, Isabel R. Houston, Jimena Ruiz, Leslie Magtanong, Scott J. Dixon, and Jennifer L. Watts. "Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity." PLOS Genetics 18, no. 9 (September 30, 2022): e1010436. http://dx.doi.org/10.1371/journal.pgen.1010436.
Loidl-Stahlhofen, A., K. Hannemann, R. Felde, and G. Spiteller. "Epoxidation of plasmalogens: source for long-chain α-hydroxyaldehydes in subcellular fractions of bovine liver." Biochemical Journal 309, no. 3 (August 1, 1995): 807–12. http://dx.doi.org/10.1042/bj3090807.
Dissertations / Theses on the topic "Plasmalogen lipids":
Schmitt, Iris Maria. "The role of plasmalogen ether lipids in the metabolic syndrome." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648371.
Wu, Yu. "Neuroprotective liquid crystalline cubosome and hexosome nanoparticle formulations by self-assembly of plasmalogen lipids and a neurotrophic peptide." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ003.
The primary aim of this thesis is to investigate the neuroprotective effect of plasmalogens (Pls) and explore the potential of lipid nanoparticles against neurodegenerative diseases. Our strategy aims to create a self-assembled system, enhancing the efficacy of plasmalogens and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection. The Pls, a distinctive group of membrane glycerophospholipids, typically contain a polyunsaturated fatty acyl chain at the sn-2 position and an alkyl chain linked by a vinyl-ether bond at the sn-1 position of the glycerol backbone. Pls, with their unique structure featuring a vinyl ether bond, possess free radical scavenging capabilities and antioxidant properties. Addressing the decline in plasmalogen levels in aging individuals holds promise for therapies related to Parkinson's disease, Alzheimer's disease, and dementia. Recent research has expanded our understanding of their antioxidant effects, anti-inflammation, and their involvement in ferroptosis. However, challenges persist in implementing plasmalogens in treatments of neurodegenerative diseases and in developing suitable drug delivery systems. We summarize the progress in lipid nanoparticles (LNPs) for targeting multiple neurodegeneration mechanisms. Our research on plasmalogen-loaded LNPs explores their fabrication mechanism and in vitro/in vivo impacts on neurodegenerative models. Our study shows the feasibility of enhancing Pls efficacy using LNPs as carriers. We employ natural plasmalogens from scallops to create nanoformulations involving a non-lamellar lipid excipient (MO) for structural stabilization, various surfactants, and small amounts of vitamin E, curcumin, or coenzyme Q10. Using small-angle X-ray scattering (SAXS), we identified the structural features of various LNPs (vesicles, cubosomes, and hexosomes). Our in vitro evaluations utilized human neuroblastoma SH-SY5Y cells, differentiated with 10 µM retinoic acid for 5 days. Cell viability tests indicated non-toxicity of the LNPs at a total lipid concentration of 10 µM for 24-hour incubation. We study the impact of Pls nanoparticles on an in vitro model of Parkinson's disease using neuronal cells induced by the neurotoxin 6-OHDA. Using the SH-SY5Y cell line, we explore cellular damage mechanisms (oxidative stress and apoptotic enzymes) via identifying the impact on the ERK-Akt-CREB-BDNF signaling pathway. Several documented neuroprotective compounds were used to demonstrate the ability to restore neuronal lesions caused by 6-OHDA, offering a model of neurodegenerative conditions to further elucidate the beneficial effects of the Pls-based LNPs. We then focus on the cAMP response element binding protein (CREB) and its phosphorylation leading to neurotrophin expression, crucial in preventing neurological disorders. Through lipid peptide nano-assemblies, we studied the impact of different structural organizations of the LNPs on CREB phosphorylation in an in vitro model of Parkinson's disease. Notably, liquid crystalline lipid nanoparticles loaded with plasmalogens prolonged CREB activation under neurodegenerative conditions, showing potential for enhanced neuroregeneration through sustained CREB activation in response to the neurotrophic nanoassemblies. In a mouse model of Parkinson's disease, vesicle and hexosome LNPs demonstrated distinct effectiveness in restoring motor function. The nanomedicine-mediated intervention influenced Parkinson's disease-related gene regulation and rebalanced lipid profiles. Nasal administration of Pls-loaded LNPs improved disease behavioral symptoms and downregulated genes like IL33 and Tnfa. The obtained results indicated the significant impact of hexosomal LNP nanomedicines on disease attenuation, lipid metabolism, and responsive gene modifications potentially involved in regeneration
Calhoon, Elisabeth Ann. "Lipids of mitochondria in fibroblasts and their nexus to life history in temperate and tropical birds." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306866847.
Abou-Zaid, Anas Mamdouh. "On the Prevalence and Role of Addition Reactions in Lipid Peroxidation." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42411.
Calhoon, Elisabeth A. "Lipid class and phospholipid species composition associated with life history variation in north temperate and neotropical birds." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1450091613.
Books on the topic "Plasmalogen lipids":
Snyder, Fred. Ether Lipids Chemistry and Biology. Elsevier Science & Technology Books, 2012.
Book chapters on the topic "Plasmalogen lipids":
Scherrer, Linda A., and Richard W. Gross. "Subcellular distribution, molecular dynamics and catabolism of plasmalogens in myocardium." In Lipid Metabolism in Normoxic and Ischemic Heart, 97–105. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1611-4_15.
Horrocks, L. A., H. W. Harder, R. Mozzi, G. Goracci, E. Francescangeli, S. Porcellati, and G. G. Nenci. "Receptor-Mediated Degradation of Choline Plasmalogens and Glycerophospholipid Methylation: A New Hypothesis." In Enzymes of Lipid Metabolism II, 707–11. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5212-9_85.
Takama, Kozo, Kazuaki Kikuchi, and Tetsuya Suzuki. "Marine Plasmalogen and its Antioxidative Effect Intake of Dietary Fish Oil into Membrane Lipid and Their Stability Against Oxidative Stress." In ACS Symposium Series, 58–65. Washington, DC: American Chemical Society, 1998. http://dx.doi.org/10.1021/bk-1998-0702.ch007.
"Assay and Purification of Plasmalogen-Selective Phospholipase A2 and Lysoplasmalogenase Activities." In Metabolism and Functions of Bioactive Ether Lipids in the Brain, 67–83. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-77401-5_4.
Farooqui, Akhlaq A., and Lloyd A. Horrocks. "Plasmalogens, platelet-activating factor, and other ether glycerophospholipids." In Bioactive Lipids, 107–34. Elsevier, 2012. http://dx.doi.org/10.1533/9780857097934.107.
"Biosynthesis of Plasmalogens in Brain." In Metabolism and Functions of Bioactive Ether Lipids in the Brain, 17–37. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-77401-5_2.
"Catabolism of Plasmalogens in Brain." In Metabolism and Functions of Bioactive Ether Lipids in the Brain, 39–65. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-77401-5_3.
"Roles of Plasmalogens in Brain." In Metabolism and Functions of Bioactive Ether Lipids in the Brain, 85–106. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-77401-5_5.
Ventura, Raúl, and María Isabel Hernández-Alvarez. "Endoplasmic Reticulum: A Hub in Lipid Homeostasis." In Updates on Endoplasmic Reticulum [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105450.
"Involvement of Plasmalogens in Neurological Disorders." In Metabolism and Functions of Bioactive Ether Lipids in the Brain, 107–27. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-77401-5_6.
Conference papers on the topic "Plasmalogen lipids":
Giuffrida, Francesca. "Identification of glycerophospholipid species in food and biological matrices by supercritical fluid chromatography coupled with high resolution mass spectrometry." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/jihg7525.
Sturk, A., M. C. L. Schaap, A. Prins Heymans, J. W. ten Cate, R. J. A. Wanders, H. S. A. Heymans, R. B. H. Schutgens, and H. van den Bosch. "SEVERELY IMPAIRED SYNTHESIS OF PLATELET ACTIVATING FACTOR IN CHONDRO DYSPLASIA PUNCTATA RHIZOMELIA PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642883.