Relevant bibliographies by topics / Plasma lyophilisé

Academic literature on the topic 'Plasma lyophilisé'

Author: Grafiati
Published: 7 July 2024
Last updated: 7 July 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Journal articles on the topic "Plasma lyophilisé":

1

Cauet, A., S. Ausset, and A. Sailliol. "Plasma lyophilisé : données de deux années d’hémovigilance active." Annales Françaises d'Anesthésie et de Réanimation 33 (September 2014): A125—A126. http://dx.doi.org/10.1016/j.annfar.2014.07.208.

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Christophe, M., C. Vauthier, C. Civadier, A. Sailliol, and V. Foissaud. "Évaluation des qualités hémostatiques du plasma lyophilisé par mesure de la génération de thrombine." Transfusion Clinique et Biologique 20, no. 3 (June 2013): 331–32. http://dx.doi.org/10.1016/j.tracli.2013.03.143.

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Jost, Daniel. "Administration préhospitalière de plasma lyophilisé « PLYO » au cours d’un choc hémorragique post-traumatique : étude « PREHO-PLYO »." Transfusion Clinique et Biologique 25, no. 4 (November 2018): 303. http://dx.doi.org/10.1016/j.tracli.2018.08.090.

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Beaume, S., B. Prunet, J. Cotte, C. N. Guyen, P. Aguillon, D. Vinciguerra, A. Sailliol, E. Meaudre, and E. Kaiser. "Utilisation du plasma lyophilisé (PLYO) en salle d’accueil des urgences vitales (SAUV) pour l’accueil des traumatisés graves." Annales Françaises d'Anesthésie et de Réanimation 33 (September 2014): A125. http://dx.doi.org/10.1016/j.annfar.2014.07.207.

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ESNAULT, P., P. J. CUNGI, P. ROMANAT, E. D’ARANDA, J. COTTE, G. LACROIX, A. VICHARD, P. AGUILLON, A. SAILLIOL, and E. MEAUDRE. "Transfusion sanguine en opération extérieure. Expérience à l’hôpital médico-chirurgical de Kaboul." Médecine et Armées Vol. 41 No. 5, Volume 41, Numéro 5 (December 1, 2013): 441–45. http://dx.doi.org/10.17184/eac.6709.

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Objectifs. - La transfusion sanguine est un des éléments majeurs du soutien médico-chirurgical des militaires en opération extérieure. Les moyens français comportent : des concentrés de globules rouges (CGR), du plasma lyophilisé (PLYO), le sang total (ST) mais ni plaquettes, ni plasma frais congelé. La stratégie transfusionnelle française en opérations militaires extérieures suit l’évolution des savoirs et des moyens. Nous décrivons ici les caractéristiques de la transfusion sanguine à l’hôpital militaire de Kaboul. Matériels et méthodes. - Étude rétrospective des dossiers des patients transfusés entre octobre 2010 et décembre 2011 à Kaboul, à partir du registre local de la transfusion sanguine. Les variables étudiées ont été: caractéristiques des patients, biologie à l’admission, type et quantité des produits transfusionnels, évolution. Résultats. - 126 patients ont été transfusés : militaires (42,3 %) dont militaires français (17,5 %), afghans (77 %), âge moyen 25 ans (+/-13,8). 273 CGR provenant de France ont été transfusés et 350, non utilisés, ont été détruits. Les pathologies ayant conduit à une transfusion ont été : blessure de guerre 60,3 %, traumatismes 16,7 %, autres 23 %. Dans les 24 premières heures, les patients ont reçu : 2,1±1,8 CGR, 1,3±2,9 poches de ST et 2,2±2,4 PLYO. Le ratio PLYO/CGR était de 1/1,6. Une transfusion massive (> 10 CGR ou ST) a concerné 7,9 % des patients. 27 % des patients ont reçu du ST. On note 13,5 % de décès. Conclusion. - L’utilisation du ST et du PLYO en substitution, respectivement, des concentrés plaquettaires et des PFC, permet d’apporter des soins de qualité dans un contexte logistiquement contraint tout en maîtrisant les coûts.
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Jennings, I., T. A. L. Woods, F. E. Preston, and S. Kitchen. "Local Calibration of International Normalised Ratio Improves between Laboratory Agreement: Results from the UK National External Quality Assessment Scheme." Thrombosis and Haemostasis 81, no. 01 (1999): 60–65. http://dx.doi.org/10.1055/s-0037-1614419.

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SummaryIn the present study we have performed local calibration of International Normalised Ratio (INR) measurement systems in a large series of laboratories. We assigned INRs to five lyophilised plasma calibrants, one prepared from normal plasma and four using plasma from war-farinised patients, using different International Reference Preparations for Thromboplastin. These five calibrants, and two lyophilised test plasmas were analysed by 349 centres using 60 different thromboplastin instrument combinations.Plasma calibrants were assigned INRs using the WHO reference thromboplastin RBT-90 or the European reference thromboplastin CRM 149R. Each participating centre determined PTs of the calibrants with their local system. These PTs were then used to construct a local calibration graph relating PT to INR. The PTs of test plasmas were converted directly into INR using the local calibration model and into INR using the conventional method. The overall medians of conventionally derived INRs of two test plasmas analysed in 349 centres were 2.50 and 3.10, compared to 2.47 and 3.04 after local calibration where RBT-90 was employed to assign INRs to calibrants. Use of CRM 149R to assign INRs to calibrants led to a significant (p <0.0001) increase in INR to 2.7 and 3.36 respectively. When results were grouped according to the thromboplastin employed, agreement between results with different reagents was improved by local calibration. There was a significant reduction (p <0.01) in the spread of results in different centres as indicated by a reduction in coefficient of variation.
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Roche, Céline, Stéphane Bouzard, Véronique Cellarier, Thomas Pouget, Benoît Clavier, and Anne Sailliol. "Formation des médecins et infirmiers à la transfusion en situation de crise – Expérience du centre de transfusion sanguine des armées dans la formation à la collecte et transfusion de sang total et de plasma lyophilisé en situation d’exception." Transfusion Clinique et Biologique 23, no. 4 (November 2016): 274–75. http://dx.doi.org/10.1016/j.tracli.2016.08.017.

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Langley, Katy, Andrew Chitolie, Ri Liesner, Marie Scully, Samuel Machin, Flora Peyvandi, and Ian Mackie. "Discrepancies between ADAMTS13 activity assays in patients with thrombotic microangiopathies." Thrombosis and Haemostasis 109, no. 03 (2013): 488–96. http://dx.doi.org/10.1160/th12-08-0565.

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SummaryADAMTS13 activity assays are sometimes useful in confirming the clinical diagnosis or to distinguish different thrombotic microangiopathies (TMA). We investigated the commonly used clinical assays for ADAMTS13 activity. 159 samples from normal subjects or acquired TMA patients were studied in collagen binding (CBA), Fret and chromogenic peptide substrate assays. Frozen aliquots of pooled normal plasma gave similar values by CBA, Fret-VWF73 peptide, Fret-VWF86 and chromogenic VWF73 ELISA (chr-VWF73). Two lyophilised commercial calibrants gave lower ADAMTS13 activity by CBA than peptide substrate assays. The addition of solid HEPES to normal plasma caused a significant fall in CBA, but not Fret-VWF73 activity and might partly explain the differences, since lyophilised plasmas are often HEPES buffered. Normal plasmas showed good agreement between CBA and Fret assays, although chr-VWF73 gave slightly higher values. In acquired TMA, there was reasonable agreement between assays for samples with <11% ADAMTS13 activity (83% of samples showed agreement between CBA, Fret-VWF73 and chr-VWF73), but samples with moderate deficiency frequently showed lower CBA levels (only 41–52% agreement). However, there were also some discrepancies among the peptide substrate assays, with Fret-VWF86 sometimes giving slightly higher values than the VWF73 substrate assays. An International reference plasma might improve standardisation, but is not the only problem. It is unclear which assay has greatest clinical utility, this may depend on the nature of the sample. If the activity does not match the clinical picture, an alternative method should be performed. Where therapeutic monitoring is required, the same activity assay should be used throughout.
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Schoenfeld, Helge, Axel Pruss, Mareike Keller, Michael Schuster, Kristian Meinck, Bruno Neuner, and Christian von Heymann. "Lyophilised plasma: evaluation of clotting factor activity over 6 days after reconstitution for transfusion." Journal of Clinical Pathology 63, no. 8 (August 2010): 726–30. http://dx.doi.org/10.1136/jcp.2010.079293.

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AimsLittle is known about long-term stability of clotting factors in dissolved human lyophilised plasma. This study evaluated clotting factor and inhibitor activity in reconstituted lyophilised plasma after storage for up to 6 days at 4°C.MethodsFive samples from different lots of pooled lyophilised plasma (LyoPlas; German Red Cross Blood Transfusion Service West) were reconstituted. The activity of fibrinogen, factor II (FII), FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII, antithrombin, plasmin inhibitor, von Willebrand factor antigen, free protein S and protein C were determined immediately and at 2, 4, 6, 24, 48, 72, 96, 120 and 144 h after reconstitution. Tests for bacterial contamination were performed after 12, 72 and 144 h from each plasma bottle.ResultsStorage at 4°C for 6 h led to a decrease in the activity of FVIII (Δ −14.9%), FIX (Δ −6.9%) and FXI (Δ −6.3%), and an increase in the activity of plasmin inhibitor (Δ +10.2%). Storage for up to 6 days resulted in a further decrease in activity of FVIII (Δ −24.3%), FIX (Δ −13.4%) and FXI (Δ −22.9%), and, additionally, a decrease in the activity of FV (Δ −15.0%), fibrinogen (Δ −6.9%) and plasmin inhibitor (Δ −17.5%). Other factors and inhibitors, with exception of protein C (Δ +8.2%), remained almost unchanged over time. Blood cultures were sterile and showed no bacterial growth.ConclusionsThe activity of all measured coagulation factors and inhibitors in a time course of up to 6 days met required quality standards. Further in vivo testing is required to demonstrate safety and efficacy of extended clinical use of refrigerated reconstituted lyophilised plasma.
10

Kitchen, S., I. Jennings, T. A. L. Woods, I. D. Walker, and F. E. Preston. "Two Recombinant Tissue Factor Reagents Compared to Conventional Thromboplastins for Determination of International Normalised Ratio: A Thirty-three-laboratory Collaborative Study." Thrombosis and Haemostasis 76, no. 03 (1996): 372–76. http://dx.doi.org/10.1055/s-0038-1650586.

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SummaryRecent advances in recombinant technology have led to the development of prothrombin time (PT) reagents containing recombinant tissue factor which has been lipidated to allow expression of procoagulant activity. In this study we have compared International Normalised Ratios (INRs) determined using two such reagents and conventional thromboplastins in widespread use in the UK.Lyophilised plasma samples from eight different warfarinised patients were distributed to 33 laboratories in the UK. Each participant determined prothrombin times on 20 local fresh normal plasmas (used to derive mean normal PT and calculate INR) and the eight lyophilised samples, using manual technique and the following thromboplastins; Recombiplastin (Ortho Diagnostics Ltd); Innovin (Baxter Diagnostics Ltd); the conventional thromboplastin in local use.For eight plasmas the mean INRs determined with different reagents were as follows: Innovin (33 laboratories) - 3.4; Manchester Reagent (MR = 8 laboratories) - 3.4; Recombiplastin (33 laboratories) - 3.7; Instrumentation Laboratory (IL = 13 laboratories) - 4.4.Mean INR results with Recombiplastin were on average 7% greater than those obtained with Innovin, 8% greater than results with MR and 18% less than INRs with IL thromboplastin. There was no significant difference between results obtained with Innovin and MR. In contrast INRs obtained with IL were markedly (mean 28%) greater than results obtained with Innovin.This study employed lyophilised plasma and it is possible that some of the relationships described are influenced by this. However, the lyo-philisation process employed did not influence the relationship between INRs of warfarinised plasmas obtained by the four main reagents described, indicating that the results are relevant to routine clinical practice.In conclusion, our data show some important differences are present between INRs determined using Recombiplastin, Innovin and two conventional thromboplastins.
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Journal articles

Dissertations / Theses on the topic "Plasma lyophilisé":

1

Dufour-Gaume, Frédérique. "Enjeux, préparation et évaluation de produits sanguins labiles innovants adaptés aux blessés de guerre." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASQ076.

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Le blessé de guerre est un blessé grave qui associe choc hémorragique et polytraumatisme. Malgré les progrès thérapeutiques des dernières années, l'hémorragie reste la première cause de décès évitable chez ce type de blessés. Les patients qui survivent aux premières heures de leurs blessures voient leur pronostic vital et fonctionnel menacé par les complications secondaires. Les protocoles de prise en charge des blessés de guerre basés sur le principe de damage control ressuscitation et la transfusion massive de sang total ont permis de réduire considérablement les décès par choc hémorragique. Toutefois, les contraintes logistiques des théâtres d'opérations extérieures et les afflux massifs de blessés ne permettent pas d'administrer du sang total à tous, en tout lieu. Le développement de produits sanguins labiles modifiés qui répondent aux contraintes opérationnelles pourrait améliorer la survie des blessés. Pour répondre à cet objectif, nous avons développé deux formulations de plasma lyophilisé hyperconcentré porcin, l'une sans (PLYO-H) et l'autre avec lyophilisat plaquettaire (PLYO-H/LP). Les produits obtenus présentaient des critères de qualité de production optimaux. Le PLYO-H et le PLYO-H/LP étaient riches en protéines, dont l'albumine, et présentent une hyperosmolarité à deux fois celle du plasma. Dans le PLYO-H/LP, les plaquettes lysées au cours du processus de fabrication ont libéré dans le plasma des facteurs de coagulation, dont le fibrinogène, en quantité importante. L'intérêt thérapeutique des PLYO-H et PLYO-H/LP a été évalué à l'aide d'un modèle porcin représentatif du blessé de guerre. La comparaison entre les animaux traités par PLYO, PLYO-H, PLYO-H/LP ou sang total n'a pas montré de supériorité d'un groupe par rapport aux autres. Toutefois, l'analyse des paramètres de la fonction cardiovasculaire et de l'hémostase a révélé des effets bénéfiques du PLYO-H et du PLYO- H/LP qui ouvrent la porte à des études complémentaires portant cette fois sur des formulations issues de plasmaphérèse humaine
War casualties associate multiple injuries with shock hemorrhage. Despite the therapeutic progress of recent years, hemorrhage is the leading cause of preventable deaths and secondary multiple organ failure can lead to vital and functional prognosis. Management of war-injured patients based on damage control resuscitation and massive transfusion of whole blood reduced considerably the number of deaths. Nevertheless, during foreign operations whole blood is sometimes lacking because of logistic limitations and massive casualties. Modified blood products that are free from constraints could help war-injured patients to survive. To achieve this objective, we developed two French hyper-concentrated lyophilized plasmas with (FLYP-H/LP) or not (FLYP-H) lyophilized platelets. The production of these products is of a high quality. FLYP-H and FLYP-H/LP are high protein products, especially albumin, which confer them a hyperosmolarity twice that of plasma. In FLYP-H/LP, platelets were lysed during the manufacturing process and liberated high quantities of coagulation factors, such as fibrinogen. The therapeutic effects of FLYP-H and FLYP-H/LP were evaluated thanks to our war-injured porcin model. Statistical analysis highlighted the beneficial effects of FLYP-H and FLYP-H/LP on cardiovascular function and hemostasis. These results open the door to more analysis but on human FLYP-H and FLYP-H/LP

Book chapters on the topic "Plasma lyophilisé":

1

TOLLU, I., K. KEARNS, and P. BENNER. "Première transfusion sanguine précoce de globules rouges dans un avion d'évacuation médicale tactique." In Médecine et Armées Vol. 46 No.2, 125–30. Editions des archives contemporaines, 2018. http://dx.doi.org/10.17184/eac.7352.

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Les lésions hémorragiques sont la première cause de mortalité évitable pour les blessés de guerre. La MEDEVAC aérienne avant l'arrivée au Role 2 peut permettre d'initier plus précocement la transfusion sanguine. Deux victimes d'un engin explosif improvisé en avril 2016 dans le nord du Mali ont bénéficié de la première transfusion sanguine préhospitalière dans le CASA Nurse entre Tessalit et Gao, c'est-à-dire lors d'une évacuation aérienne tactique intra-théâtre. L'éventuel bénéfice de la transfusion préhospitalière a fait l'objet de nombreux travaux, tant en milieu civil que militaire, sur le plan de la survie, de l'état hémodynamique ou des besoins transfusionnels ultérieurs. Sa faisabilité a été mise en évidence, sous réserve d'une préparation mettant en collaboration les équipes médicales du Role 2 et du CASA Nurse pour le matériel et l'entraînement, et répondant à des besoins en termes de partage des tâches, d'organisation d'un plan de travail, de tiédissement avant utilisation et de conservation des concentrés globulaires. La mise en oeuvre d'une transfusion de concentrés de globules rouges associée à du Plasma lyophilisé aussi vite que possible dans la prise en charge d'un blessé hémorragique passe par son utilisation au cours de la MEDEV AC tactique, ce que le CASA Nurse rend possible. Les modalités de cette pratique doivent être définies et enseignées. Cette transfusion préhospitalière au cours de la MEDEV AC tactique peut compléter les atouts de l'avion MEDEVAC, en association aux plasmas lyophilisés déjà reçus sur le terrain et en laissant au premier plan l'objectif d'une MEDEVAC rapide.

Conference papers on the topic "Plasma lyophilisé":

1

Choo, J. H., H. A. Spikes, M. Ratoi, R. P. Glovnea, and A. Forrest. "A Technique for the Detection of Liquid Slip at a Load-Bearing, High Shear Contact." In World Tribology Congress III. ASMEDC, 2005. http://dx.doi.org/10.1115/wtc2005-64269.

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This research aims to exploit the physical phenomenon of simple liquids slipping against very smooth solid surfaces, to create a new type of bearing where the lubricant slips against one surface but not the other. To demonstrate the feasibility of this idea, a special test rig capable of measuring milli-Newton forces has been employed to measure friction in high-speed, sliding contacts between a steel roller and sapphire window, lubricated by hexadecane. Sapphire was made either lyophobic by coating with a self-assembled silane monolayer, or lyophilic by O2-plasma cleaning. The roller was made lyophilic. A significant reduction in friction was achieved with lyophobic sapphire but not with lyophilic sapphire. This reduced friction is believed to result from lubricant slip against the lyophobic surface. One possible application of such a bearing will be in microsystems and devices.
2

Poller, L., J. M. Thomson, and D. A. Taberner. "THE IMPLEMENTATION OF THE WHO INTERNATIONAL NORMALISED RATIO (INR) SYSTEM OF PROTHROMBIN TIME STANDARDISATION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643259.

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The implementation of the INR system has been assessed in a group of laboratories from over fifty countries. These centres participate in the World Health Organisation International Quality Control Programme in Blood Coagulation. Prothrombin times are performed on various lyophilised human coumarinised plasmas using both the local thromboplastin reagent and British Comparative Thromboplastin (BCT) reference preparation. During 1985 and 1986 a programme of education has been undertaken whereby instructions in the derivation of INR values have been given. The calculation of INR has been shown by means of a worked example and a chart for the conversion of the prothrombin ratio with BCT to INR was included. Prior to this, prothrombin results were expressed as British Corrected Ratios (BCR) with a minority of centres using INR. In 1984 the CV varied between 23.7% - 36.8% for results with local reagents, but between 8.2% - 14.3% with BCT. This suggested that conversion into INR/ BCR was unsatisfactory. The table shows the impact of the continuing educational programme.The number of laboratories expressing results as INR has steadily increased and the CV is now approaching that obtained with BCT. The improvement in CV suggests that the general application of the INR system will help improve inter-laboratory standardisation of oral anticoagulant control and should be encouraged.

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