Journal articles: 'Plant bioactive compounds'

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van Staden, Johannes. "Biochemical Targets of Plant Bioactive Compounds." South African Journal of Botany 71, no. 3-4 (November 2005): 451. http://dx.doi.org/10.1016/s0254-6299(15)30121-6.

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., MIFTAHUDIN, DWI SUCI SETYANINGSIH, and TATIK CHIKMAWATI. "Pertumbuhan dan Kandungan Bahan Bioaktif Selaginella plana dan Selaginellla willdenovii pada Beberapa Media Tanam." Jurnal Sumberdaya Hayati 1, no. 1 (October 22, 2015): 1–6. http://dx.doi.org/10.29244/jsdh.1.1.1-6.

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Selaginella, a genus of Pteridophyte, is known as an herb that contains of several bioactive compounds. The growth and bioactive compounds of plant were affected by plant environment, such as media types. The objective of the research was to obtain an appropriate plant media for growing S. plana dan S. willdenovii, and its effect on the content of bioactive compounds. The experiment consisted of two factors, plant growth media and the species of Selaginella. The first factor consisted of eight plant growth media, i.e.: soil, rice husk, rice husk : soil = 1:1 (v/v), burned rice husk, soil : burned rice huks = 1:1 (v/v), burned rice husk : rice husk = 1:1 (v/v), burned rice husk : rice husk = 3:1 (v/v), and burned rice husk : rice husk = 1:3 (v/v). The second factor was two spesies of Selaginella, i.e.: S. plana and S. willdenovii. Ethanol extract of Selaginella was qualitatively analyzed for flavonoid, tannin, and saponin content. The result showed that both fresh and dry weights of Selaginella were influenced by the type of plant media, Selaginella species, and their interactions. S. plana and S. willdenovii grew best on medium containing soil: burned rice = 1:1 (v/v). The highest flavonoid content of S. plana and S. willdenovii was also obtained from the plant grown on the same media. Comparing to the bioactive compound content of natural plant, saponin content of S. plana and S. willdenovii was increased by the treatment of plant media. The treatment also increased tannin content of S. plana, but not of S. willdenovii.

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El-Ramady, Hassan, Peter Hajdú, Gréta Törős, Khandsuren Badgar, Xhensila Llanaj, Attila Kiss, Neama Abdalla, et al. "Plant Nutrition for Human Health: A Pictorial Review on Plant Bioactive Compounds for Sustainable Agriculture." Sustainability 14, no. 14 (July 7, 2022): 8329. http://dx.doi.org/10.3390/su14148329.

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Is there any relationship between plant nutrition and human health? The overall response to this question is very positive, and a strong relationship between the nutrition of plants and humans has been reported in the literature. The nutritional status of edible plants consumed by humans can have a negative or positive impact on human health. This review was designed to assess the importance of plant bioactive compounds for human health under the umbrella of sustainable agriculture. With respect to the first research question, it was found that plant bioactives (e.g., alkaloids, carotenoids, flavonoids, phenolics, and terpenoids) have a crucial role in human health due to their therapeutic benefits, and their potentiality depends on several factors, including botanical, environmental, and clinical attributes. Plant bioactives could be produced using plant tissue culture tools (as a kind of agro-biotechnological method), especially in cases of underexploited or endangered plants. Bioactive production of plants depends on many factors, especially climate change (heat stress, drought, UV radiation, ozone, and elevated CO2), environmental pollution, and problematic soils (degraded, saline/alkaline, waterlogged, etc.). Under the previously mentioned stresses, in reviewing the literature, a positive or negative association was found depending on the kinds of stress or bioactives and their attributes. The observed correlation between plant bioactives and stress (or growth factors) might explain the importance of these bioactives for human health. Their accumulation in stressed plants can increase their tolerance to stress and their therapeutic roles. The results of this study are in keeping with previous observational studies, which confirmed that the human nutrition might start from edible plants and their bioactive contents, which are consumed by humans. This review is the first report that analyzes this previously observed relationship using pictorial presentation.

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Lee, Bonggi, and Choon Young Kim. "Dietary Bioactive Compounds and Health." Foods 11, no. 16 (August 10, 2022): 2395. http://dx.doi.org/10.3390/foods11162395.

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Rath, Sonali, Manaswini Jagadeb, and Ruchi Bhuyan. "Molecular docking of bioactive compounds derived from Moringa oleifera with p53 protein in the apoptosis pathway of oral squamous cell carcinoma." Genomics & Informatics 19, no. 4 (December 31, 2021): e46. http://dx.doi.org/10.5808/gi.21062.

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Moringa oleifera is nowadays raising as the most preferred medicinal plant, as every part of the moringa plant has potential bioactive compounds which can be used as herbal medicines. Some bioactive compounds of M. oleifera possess potential anti-cancer properties which interact with the apoptosis protein p53 in cancer cell lines of oral squamous cell carcinoma. This research work focuses on the interaction among the selected bioactive compounds derived from M. oleifera with targeted apoptosis protein p53 from the apoptosis pathway to check whether the bioactive compound will induce apoptosis after the mutation in p53. To check the toxicity and drug-likeness of the selected bioactive compound derived from M. oleifera based on Lipinski’s Rule of Five. Detailed analysis of the 3D structure of apoptosis protein p53. To analyze protein’s active site by CASTp 3.0 server. Molecular docking and binding affinity were analyzed between protein p53 with selected bioactive compounds in order to find the most potential inhibitor against the target. This study shows the docking between the potential bioactive compounds with targeted apoptosis protein p53. Quercetin was the most potential bioactive compound whereas kaempferol shows poor affinity towards the targeted p53 protein in the apoptosis pathway. Thus, the objective of this research can provide an insight prediction towards M. oleifera derived bioactive compounds and target apoptosis protein p53 in the structural analysis for compound isolation and in-vivo experiments on the cancer cell line.

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Hager, Roland, Johannes Pitsch, Jakob Kerbl-Knapp, Cathrina Neuhauser, Nicole Ollinger, Marcus Iken, Josef Ranner, et al. "A High-Content Screen for the Identification of Plant Extracts with Insulin Secretion-Modulating Activity." Pharmaceuticals 14, no. 8 (August 17, 2021): 809. http://dx.doi.org/10.3390/ph14080809.

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Bioactive plant compounds and extracts are of special interest for the development of pharmaceuticals. Here, we describe the screening of more than 1100 aqueous plant extracts and synthetic reference compounds for their ability to stimulate or inhibit insulin secretion. To quantify insulin secretion in living MIN6 β cells, an insulin–Gaussia luciferase (Ins-GLuc) biosensor was used. Positive hits included extracts from Quillaja saponaria, Anagallis arvensis, Sapindus mukorossi, Gleditsia sinensis and Albizia julibrissin, which were identified as insulin secretion stimulators, whereas extracts of Acacia catechu, Myrtus communis, Actaea spicata L., Vaccinium vitis-idaea and Calendula officinalis were found to exhibit insulin secretion inhibitory properties. Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) were used to characterize several bioactive compounds in the selected plant extracts, and these bioactives were retested for their insulin-modulating properties. Overall, we identified several plant extracts and some of their bioactive compounds that may be used to manipulate pancreatic insulin secretion.

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Teo, Stephen P., Sanjib Bhakta, Paul Stapleton, and Simon Gibbons. "Bioactive Compounds from the Bornean Endemic Plant Goniothalamus longistipetes." Antibiotics 9, no. 12 (December 16, 2020): 913. http://dx.doi.org/10.3390/antibiotics9120913.

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The present study aimed to screen plants for bioactive compounds with potential antibacterial activities. In our efforts to evaluate plants from Borneo, we isolated and elucidated the structures of four natural products from the bioactive fraction of a chloroform extract of Goniothalamus longistipetes using various chromatographic and spectroscopic techniques. The bioactive compounds were identified as a known styryllactone, (+)-altholactone ((2S,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrobenzo-5(4H)-5-one) (1), a new styryllactone, (2S,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrobenzo-5(4H)-5-one) (2) as well as a new alkaloid, 2,6-dimethoxyisonicotinaldehyde (3) and a new alkenyl-5-hydroxyl-phenyl benzoic acid (4). 1 and 4 showed broad-spectrum anti-bacterial activities against Gram-positive and Gram-negative bacteria as well as acid-fast model selected for this study. Compound 2 only demonstrated activities against Gram-positive bacteria whilst 3 displayed selective inhibitory activities against Gram-positive bacterial strains. Additionally, their mechanisms of anti-bacterial action were also investigated. Using Mycobacterium smegmatis as a fast-growing model of tubercle bacilli, compounds 1, 2 and 4 demonstrated inhibitory activities against whole-cell drug efflux and biofilm formation; two key intrinsic mechanisms of antibiotic resistance. Interestingly, the amphiphilic compound 4 exhibited inhibitory activity against the conjugation of plasmid pKM101 in Escherichia coli using a plate conjugation assay. Plasmid conjugation is a mechanism by which Gram-positive and Gram-negative-bacteria acquire drug resistance and virulence. These results indicated that bioactive compounds isolated from Goniothalamus longistipetes can be potential candidates as ‘hits’ for further optimisation.

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Schlemmer, Ulrich. "Selected Bioactive Plant Compounds in Human Nutrition." Molecular Nutrition & Food Research 53, S2 (September 2009): S145. http://dx.doi.org/10.1002/mnfr.200990030.

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Hanum, Laila, and Rina S. Kasiamdari. "Tumbuhan Duku: Senyawa Bioaktif, Aktivitas Farmaklogis dan Prospeknya dalam Bidang Kesehatan." JURNAL BIOLOGI PAPUA 5, no. 2 (October 14, 2018): 84–93. http://dx.doi.org/10.31957/jbp.528.

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Lansium domesticum Corr. (Meliaceae) is the popular tropical plant producing economic edible fruits found mainly in Southeast Asia. Seed, leaf, bark, stalks and fruit skin extracts of this plant are potential sources for compounds with broad spectrum of pharmacological activities such as antitumor, anticancer, antimalaria, antimelanogenesis, antibacteria and it may lead to the discovery of a new compouds used for antimutagenic and antioxidative stress. Bioactive compounds, pharmacological activities and prospect this plant in medical application will be discussed in this paper. Key words: Lansium domesticum, bioactive compounds, pharmacological activities, medical application.

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Shrivastava, Rashmi, and Jyotsana Mishra. "Extraction, Phytochemical Screening, Isolation and Identification of Bioactive Compounds from Extract of the plant Euphorbia Thymifolia Linn." Journal of Drug Delivery and Therapeutics 9, no. 3 (May 15, 2019): 107–13. http://dx.doi.org/10.22270/jddt.v9i3.2608.

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Medicinal plants play an important role in the development of potent therapeutic agents. Plant based drugs provide outstanding contribution to modern therapeutics as a source of many valuable secondary metabolites which serves as plant defense mechanisms against predator such as microorganism, insects and herbivores which have been proved to be potentially active compounds. Euphorbia Thymifolia Linn (E. Thymifolia) is commonly known as ‘duddi’ or in Sanskrit means Laghu didhika or Raktavindaka. It belongs to the family Euphorbiceae. This plant is bitter, acrid, sweet and used as thermogenic, laxative and diuretic. This plant is widely used in the ayurveda to cure many diseases like vitiated condition of constipation, helminthiasis and ringworm skin diseases and leprosy. The aim of the present study is to examine E.Thymifolia Linn whole plant for phytochemical profile, Isolation and Identification of bioactive compounds. Qualitative analysis of various phytochemical constituents was determined by the well-known test protocol available in the literature. Isolation and characterization of bioactive compound from methanolic extract of E. Thymifolia has been conducted. The bioactive compound from methanolic extracts was isolated by several processes, such as TLC, column chromatography and preparative TLC. The isolated bioactive compound is identified by UV-Vis spectrophotometer, FT-IR, 1H, 13C-NMR and Mass. The obtained compound is continued to the preparative TLC using chloroform: methanol (50:50, v/v) as eluent. The UV-Vis spectrum showed one peaks of maximum absorbance at 312.8nm. Then, the FT-IR spectrum showed several peaks that confirmed the presence of functional group of derivative of compound, i.e. 669.05, 928.58, 1070.85, 1215.51 and 1710.07cm-1. 1H and 13C-NMR spectrum confirmed the bioactive compound present in plant. Phytochemical analysis revealed the presence of alkaloids, glycosides, phenols, flavonoids, tannins. The findings of the present study will be helpful to phytochemists, pharmacologists and pharmaceutical industries. Keywords: Euphorbia Thymifolia, Qualitative phytochemical, Isolation, Bioactive compounds

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Vaou, Natalia, Elisavet Stavropoulou, Chrysoula (Chrysa) Voidarou, Zacharias Tsakris, Georgios Rozos, Christina Tsigalou, and Eugenia Bezirtzoglou. "Interactions between Medical Plant-Derived Bioactive Compounds: Focus on Antimicrobial Combination Effects." Antibiotics 11, no. 8 (July 28, 2022): 1014. http://dx.doi.org/10.3390/antibiotics11081014.

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It is accepted that the medicinal use of complex mixtures of plant-derived bioactive compounds is more effective than purified bioactive compounds due to beneficial combination interactions. However, synergy and antagonism are very difficult to study in a meticulous fashion since most established methods were designed to reduce the complexity of mixtures and identify single bioactive compounds. This study represents a critical review of the current scientific literature on the combined effects of plant-derived extracts/bioactive compounds. A particular emphasis is provided on the identification of antimicrobial synergistic or antagonistic combinations using recent metabolomics methods and elucidation of approaches identifying potential mechanisms that underlie their interactions. Proven examples of synergistic/antagonistic antimicrobial activity of bioactive compounds are also discussed. The focus is also put on the current challenges, difficulties, and problems that need to be overcome and future perspectives surrounding combination effects. The utilization of bioactive compounds from medicinal plant extracts as appropriate antimicrobials is important and needs to be facilitated by means of new metabolomics technologies to discover the most effective combinations among them. Understanding the nature of the interactions between medicinal plant-derived bioactive compounds will result in the development of new combination antimicrobial therapies.

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Ware, Ismail, Katrin Franke, Hidayat Hussain, Ibrahim Morgan, Robert Rennert, and Ludger Wessjohann. "Bioactive Phenolic Compounds from Peperomia obtusifolia." Molecules 27, no. 14 (July 7, 2022): 4363. http://dx.doi.org/10.3390/molecules27144363.

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Peperomia obtusifolia (L.) A. Dietr., native to Middle America, is an ornamental plant also traditionally used for its mild antimicrobial properties. Chemical investigation on the leaves of P. obtusifolia resulted in the isolation of two previously undescribed compounds, named peperomic ester (1) and peperoside (2), together with five known compounds, viz. N-[2-(3,4-dihydroxyphenyl)ethyl]-3,4-dihydroxybenzamide (3), becatamide (4), peperobtusin A (5), peperomin B (6), and arabinothalictoside (7). The structures of these compounds were elucidated by 1D and 2D NMR techniques and HREIMS analyses. Compounds 1–7 were evaluated for their anthelmintic (against Caenorhabditis elegans), antifungal (against Botrytis cinerea, Septoria tritici and Phytophthora infestans), antibacterial (against Bacillus subtilis and Aliivibrio fischeri), and antiproliferative (against PC-3 and HT-29 human cancer cell lines) activities. The known peperobtusin A (5) was the most active compound against the PC-3 cancer cell line with IC50 values of 25.6 µM and 36.0 µM in MTT and CV assays, respectively. This compound also induced 90% inhibition of bacterial growth of the Gram-positive B. subtilis at a concentration of 100 µM. In addition, compound 3 showed anti-oomycotic activity against P. infestans with an inhibition value of 56% by using a concentration of 125 µM. However, no anthelmintic activity was observed.

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Ju, Jin-Hee, Yong-Han Yoon, So-Hui Shin, Se-Young Ju, and Kyung-Jin Yeum. "Recent Trends in Urban Agriculture to Improve Bioactive Content of Plant Foods." Horticulturae 8, no. 9 (August 26, 2022): 767. http://dx.doi.org/10.3390/horticulturae8090767.

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Urban agriculture is an important part of the food and nutrition security of many cities and is growing in importance, especially with social disruptions such as climate change and pandemics. Plant foods, in particular, provide bioactive compounds and other essential nutrients. Therefore, it is important to provide timely and useful research resources to horticultural sector and food-related industries that want to produce high-quality plant foods at low cost to meet the market demands of urban agriculture. This study focuses on up-to-date information on urban agriculture, the mechanisms of production of bioactive compounds in plant foods, and the main factors influencing the levels of bioactive compounds in plant foods. As a strategy to improve the bioactive compounds of plant foods in urban agriculture, the recent trends in urban agriculture were investigated according to four categories: ground-based uncontrolled or controlled agriculture and building-integrated uncontrolled or controlled agriculture. In ground-based urban agriculture, the application of short-term abiotic or biotic stresses, such as agronomic management practices, can significantly affect the bioactive compound levels in fruits and vegetables. On the other hand, in building-integrated urban agriculture, horticultural scientists have been interested in artificial lighting, cultivation medium, and water use efficiency to improve the level and composition of functional components of plants. The future trend of urban agriculture is expected to change from ground-based to building integration considering the sustainability of agriculture. Therefore, ongoing research on the growth and bioactive content improvement of plant foods using building-integrated agriculture is an important aspect for urban agriculture.

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Uwineza, Pascaline Aimee, and Agnieszka Waśkiewicz. "Recent Advances in Supercritical Fluid Extraction of Natural Bioactive Compounds from Natural Plant Materials." Molecules 25, no. 17 (August 24, 2020): 3847. http://dx.doi.org/10.3390/molecules25173847.

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In this review, recent advances in greener technology for extracting natural bioactive components from plant origin sources are discussed. Bioactive compounds of plant origin have been defined as natural chemical compounds present in small amounts in plants. Researchers have shown interest in extracting bioactive compounds because of their human health benefits and characteristics of being eco-friendly and generally recognized as safe. Various new extraction methods and conventional extraction methods have been developed, however, until now, no unique approach has been presented as a benchmark for extracting natural bioactive compounds from plants. The selectivity and productivity of traditional and modern extraction techniques generally depend on selecting the critical input parameters, knowing the nature of plant-based samples, the structure of bioactive compounds, and good scientific skills. This work aims to discuss the recent advances in supercritical fluid extraction techniques, especially supercritical carbon dioxide, along with the fundamental principles for extracting bioactive compounds from natural plant materials such as herbs, spices, aromatic and medicinal plants.

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Souza, Alexandra Goede de, Eduardo Affonso Jung, Vinícius Petermann Benedicto, and Leosane Cristina Bosco. "Bioactive compounds in gladiolus flowers." Ornamental Horticulture 27, no. 3 (September 2021): 296–303. http://dx.doi.org/10.1590/2447-536x.v27i3.2310.

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Abstract Flowers have received special attention not only for their ornamental nature but also for their nutraceutical, cosmetic, aromatic, and culinary properties. This study aimed to characterize physicochemical attributes and the antioxidant capacity of flowers of four gladiolus cultivars. The cultivars used were White Friendship, Rose Supreme, Jester, and T704. We analyzed the content of total soluble solids (SS), total titratable acidity (TA), SS/TA ratio, pH, vitamin C, anthocyanin, flavonoids, total phenolic compounds (TPC), total antioxidant activity (TAA), and the relationship of TPC with flavonoids and TAA for each cultivar. The results showed that the Jester flowers had the lowest TA and highest SS/TA ratio, indicating the best flavor. Jester also had the highest flavonoid content, similarly to the White Friendship and Rose Supreme. As a result, these cultivars have flowers with higher TPC and TAA content than T704. The anthocyanin content was the characteristic attribute of cultivar T704, due to its purple pigmentation. Gladiolus flowers, traditionally used in landscaping and as cut flowers, have the potential for use in human nutrition, particularly the White Friendship, Rose Supreme, and Jester cultivars.

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Juárez-Maldonado, Antonio, Hortensia Ortega-Ortíz, Gregorio Cadenas-Pliego, Jesús Valdés-Reyna, José Pinedo-Espinoza, César López-Palestina, and Alma Hernández-Fuentes. "Foliar Application of Cu Nanoparticles Modified the Content of Bioactive Compounds in Moringa oleifera Lam." Agronomy 8, no. 9 (August 29, 2018): 167. http://dx.doi.org/10.3390/agronomy8090167.

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Moringa oleifera Lam is a plant that has recently gained importance as a food because of its nutritional value and bioactive compound content and because practically all the organs are usable. The use of nanoparticles has appeared as an alternative to increase bioactive compounds in plants. The goal of this work was to determine if the application of copper nanoparticles would increase the content of bioactive compounds and antioxidant capacity in M. oleifera. Copper (Cu) nanoparticles were applied to the leaves at four different times throughout crop growth. The biocompounds were analyzed after the second, third, and fourth applications. The results show that application of Cu nanoparticles has a beneficial effect on the accumulation of bioactive compounds in M. oleifera leaves. In addition, the antioxidant capacity and carotenoid and chlorophyll contents in the leaves of M. oleifera increased after Cu nanoparticles application. The same effect was not observed in the fruit of M. oleifera. Here, the bioactive compound contents diminished. Therefore, the use of Cu nanoparticles can be an important alternative to improve the quality of this plant, particularly that of the leaves.

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Ramatapa, Thabo, Anathi Msobo, Pfano W. Maphari, Efficient N. Ncube, Noluyolo Nogemane, and Msizi I. Mhlongo. "Identification of Plant-Derived Bioactive Compounds Using Affinity Mass Spectrometry and Molecular Networking." Metabolites 12, no. 9 (September 14, 2022): 863. http://dx.doi.org/10.3390/metabo12090863.

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Affinity selection-mass spectrometry (AS-MS) is a label-free binding assay system that uses UHPLC-MS size-based separation methods to separate target-compound complexes from unbound compounds, identify bound compounds, classify compound binding sites, quantify the dissociation rate constant of compounds, and characterize affinity-extracted ligands. This label-free binding assay, in contrast to conventional biochemical (i.e., high-throughput screening (HTS)) approaches, is applicable to any drug target, and is also concise, accurate, and adaptable. Although AS-MS is an innovative approach for identifying lead compounds, the possibilities of finding bioactive compounds are limited by competitive binding, which occurs during the equilibration of extracts with the target protein(s). Here, we discuss the potential for metabolite profiling complemented with molecular networking to be used alongside AS-MS to improve the identification of bioactive compounds in plant extracts. AS-MS has gained significant prominence in HTS labs and shows potential to emerge as the driving force behind novel drug development in the future.

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Saunders, David, Daniel Poppleton, Anton Struchkov, and Robert Ireland. "Analysis of five bioactive compounds from naturally occurring Rhodiola rosea in eastern Canada." Canadian Journal of Plant Science 94, no. 4 (May 2014): 741–48. http://dx.doi.org/10.4141/cjps2013-177.

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Saunders, D., Poppleton, D., Struchkov, A. and Ireland, R. 2014. Analysis of five bioactive compounds from naturally occurring Rhodiola rosea in eastern Canada. Can. J. Plant Sci. 94: 741–748. The plant Rhodiola rosea produces several bioactive compounds including salidroside, tyrosol, rosarin, rosavin, and rosin. These compounds have been used in traditional medicinal practices in Asia and are currently found in many nutraceutical mixtures. The nutraceutical qualities of these five compounds has resulted in over harvesting of natural populations of R. rosea and instigated several industrial cultivation operations. The purpose of this study was to examine R. rosea from five distinct natural populations in the maritime provinces of Canada to determine the concentrations of these five bioactive compounds. Ten samples were obtained from each of five sites and the concentration of each compound in the rhizomes was determined. Reverse phase-HPLC with a diode array detector was used to quantify the five compounds extracted from plant samples. The concentrations of salidroside were found to be as high as 1.76% of total dry weight, tyrosol 0.28%, rosarin 1.1%, rosavin 2.14%, and rosin 0.31%. To the best of our knowledge, this is one of the first studies to determine rhizomal concentrations of the five bioactive compounds in natural Canadian samples of R. rosea.

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Jiang, Lin-Lin, Xue Gong, Ming-Yue Ji, Cong-Cong Wang, Jian-Hua Wang, and Min-Hui Li. "Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia." Foods 9, no. 8 (July 23, 2020): 973. http://dx.doi.org/10.3390/foods9080973.

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Hyperuricemia is a common metabolic disease that is caused by high serum uric acid levels. It is considered to be closely associated with the development of many chronic diseases, such as obesity, hypertension, hyperlipemia, diabetes, and cardiovascular disorders. While pharmaceutical drugs have been shown to exhibit serious side effects, and bioactive compounds from plant-based functional foods have been demonstrated to be active in the treatment of hyperuricemia with only minimal side effects. Indeed, previous reports have revealed the significant impact of bioactive compounds from plant-based functional foods on hyperuricemia. This review focuses on plant-based functional foods that exhibit a hypouricemic function and discusses the different bioactive compounds and their pharmacological effects. More specifically, the bioactive compounds of plant-based functional foods are divided into six categories, namely flavonoids, phenolic acids, alkaloids, saponins, polysaccharides, and others. In addition, the mechanism by which these bioactive compounds exhibit a hypouricemic effect is summarized into three classes, namely the inhibition of uric acid production, improved renal uric acid elimination, and improved intestinal uric acid secretion. Overall, this current and comprehensive review examines the use of bioactive compounds from plant-based functional foods as natural remedies for the management of hyperuricemia.

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Reynolds, T., Derek J. Chadwick, and Joan March. "Bioactive Compounds from Plants." Kew Bulletin 47, no. 1 (1992): 150. http://dx.doi.org/10.2307/4110780.

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Phupaboon, Srisan, Maharach Matra, Ronnachai Prommachart, Pajaree Totakul, Chanadol Supapong, and Metha Wanapat. "Extraction, Characterization, and Chitosan Microencapsulation of Bioactive Compounds from Cannabis sativa L., Cannabis indica L., and Mitragyna speiosa K." Antioxidants 11, no. 11 (October 25, 2022): 2103. http://dx.doi.org/10.3390/antiox11112103.

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The objective of the research was to investigate the bioactive compounds of herbal plant leaves by microencapsulation technique for future application as a feed additive. In this experiment, three herbal plant leaves, namely Cannabis sativa L., Cannabis indica L., and Mitragyna speiosa K., were comparatively investigated using different methods to extract their bioactive compounds. Two methods were used to extract the bioactive compounds: microwave extraction (water-heating transferred) and maceration extraction (methanol extracted). The results obtained using microwave extraction revealed that the total polyphenolic and flavonoid contents and antioxidant capacity were significantly higher and stronger, respectively, than those produced by the maceration extraction method (p < 0.05). Furthermore, the spray-drying technique was employed to enhance the extracted compounds by encapsulation with chitosan through ionic gelation properties. The physical characteristics of chitosan-encapsulated substrates were examined under a scanning electron microscope (SEM) and were as microparticle size (1.45 to 11.0 µm). The encapsulation efficiency of the bioactive compounds was found to be 99.7, 82.3, and 54.6% for microencapsulated M. speiosa, C. indica, and C. sativa, respectively. Therefore, microwave treatment prior to chitosan encapsulation of leaf extracts resulted in increased recovery of bioactive compound encroachment.

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Hosen, S. M. Zahid, Md Junaid, Muhammad Shaiful Alam, Maruf Rubayed, Raju Dash, Rasheda Akter, Tania Sharmin, et al. "GreenMolBD: Nature Derived Bioactive Molecules' Database." Medicinal Chemistry 18, no. 6 (July 2022): 724–33. http://dx.doi.org/10.2174/1573406418666211129103458.

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Background: One of the essential resources for developing new drugs are naturally derived biologically active lead compounds. Biomedical researchers and pharmaceutical companies are highly interested in these plant-derived molecules to develop the new drug. In this process, collective information of the plants and their phytoconstituents with different properties and descriptors would greatly benefit the researchers to identify the hit, lead or drug-like compound. Aim and Objective: Therefore, the work intended to develop a unique and dynamic database Green- MolBD to provide collective information regarding medicinal plants, such as their profile, chemical constituents, and pharmacological evidence. We also aimed to present information of phytoconstituents, such as in silico description, quantum, drugability and biological target information. Method: For data mining, we covered all accessible literature and books, and for in silico analysis, we employed a variety of well-known software and servers. The database is integrated by MySQL, HTML, PHP and JavaScript. Result: GreenMolBD is a freely accessible database and searchable by keywords, plant name, synonym, common name, family name, family synonym, compound name, IUPAC name, InChI Key, target name, and disease name. We have provided a complete profile of individual plants and each compound’s physical, quantum, drug likeliness, and toxicity properties (48 type’s descriptor) using in silico tools. A total of 1846 associated targets related to 6,864 compounds already explored in different studies are also incorporated and synchronized. Conclusion: This is the first evidence-based database of bioactive molecules from medicinal plants specially grown in Bangladesh, which may help explore and foster nature-inspired rational drug discovery.

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Lam, Vu Phong, Sung Jin Kim, Gwon Jeong Bok, Jong Won Lee, and Jong Seok Park. "The Effects of Root Temperature on Growth, Physiology, and Accumulation of Bioactive Compounds of Agastache rugosa." Agriculture 10, no. 5 (May 11, 2020): 162. http://dx.doi.org/10.3390/agriculture10050162.

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Plants respond to root temperature stresses by producing antioxidants as a defense mechanism. Since a number of these are phytochemicals with enhancing effects on human health, we examined the effects of 4 root-zone temperature (RZT) treatments (10, 20, 28, and 36 °C) on plant growth and the main bioactive compound concentrations in each organ of Agastache rugosa plants. We aimed to determine the optimal RZT treatment to increase bioactive compound concentrations with no deleterious effects on plant growth. Four-week-old seedlings were grown in a plant factory for 32 days. Nine plant growth parameters, namely, shoot and root fresh weights, stem and root lengths, leaf length and leaf width, leaf area, and shoot and root dry weights were significantly decreased at 10 and 36 °C compared with other treatments. A similar pattern was observed for the chlorophyll content and leaf gas exchange parameters. Of all the RZT treatments, RZT at 28 °C produced the significantly greatest accumulation of two major bioactive compounds, namely, rosmarinic acid (RA) and tilianin contents per the A. rugosa plant, and had no adverse effects on the overall growth of A. rugosa. This supports the use of 28 °C RZT to successfully improve the bioactive compounds with no adverse influence on plant growth or yield.

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Suryavanshi, Anandika, and Anand Murari Saxena. "Phytochemicals: Extraction and Preliminary Investigation of Bioactive Compounds from Rumex Vesicarius and Terminalia Catappa Plant." Asian Journal of Engineering and Applied Technology 8, no. 3 (November 5, 2019): 21–24. http://dx.doi.org/10.51983/ajeat-2019.8.3.1131.

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The present study was carried out for the determination of bioactive compounds from different extracts of Terminalia catappa and Rumex vesicarius. The plants are mines of several bioactive compounds also called as phytochemical compounds. These bioactive compounds are responsible for imparting such a potential medicinal property in the plants. The medicinal plant contains various types of bioactive compounds including phenols, alkaloids, terpenoids, tannins, glycosides, flavonoids etc. These bioactive compounds take part in various metabolic pathways and impart their effect. Terminalia catappa and Rumex vesicarius are such medicinal plants which are being used for medicinal purposes for long time. Both of them are rich source of potential bioactive compounds and hence carry out several biological activities effective for the treatment of various diseases. Hence the study focuses on determining the types of bioactive compounds they acquire. For this the leaves of T. catappa and dry stems of R. vesicarius were used for the extraction using different solvents with soxhlet method. The extract of different solvents was analyzed for the phytochemical test. The results obtained revealed that the type of solvents is crucial in determining the type of bioactive compounds to be present in extract. The results showed that ethanol and methanol are good solvent choice for extraction for these two plants. The results concludes that the presence of such potential and effective bioactive compounds in their extract makes them important medicinal plants and are hence employed for several researches and also used for treatment of various kinds of diseases.

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Okechukwu Ohiagu, Franklyn, Paul Chidoka Chikezie, and Chinwendu Maureen Chikezie. "Toxicological Significance of Bioactive Compounds of Plant Origin." Pharmacognosy Communications 11, no. 2 (April 7, 2021): 67–77. http://dx.doi.org/10.5530/pc.2021.2.15.

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Zhao, J., T. Shan, Y. Mou, and L. Zhou. "Plant-Derived Bioactive Compounds Produced by Endophytic Fungi." Mini-Reviews in Medicinal Chemistry 11, no. 2 (February 1, 2011): 159–68. http://dx.doi.org/10.2174/138955711794519492.

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Pinho, Eva, Martin Grootveld, Graça Soares, and Mariana Henriques. "Cyclodextrins as encapsulation agents for plant bioactive compounds." Carbohydrate Polymers 101 (January 2014): 121–35. http://dx.doi.org/10.1016/j.carbpol.2013.08.078.

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Hadidi, Milad, Chen Tan, Elham Assadpour, Mohammad Saeed Kharazmi, and Seid Mahdi Jafari. "Emerging plant proteins as nanocarriers of bioactive compounds." Journal of Controlled Release 355 (March 2023): 327–42. http://dx.doi.org/10.1016/j.jconrel.2023.01.069.

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Roy, Arpita. "Hairy Root Culture an Alternative for Bioactive Compound Production from Medicinal Plants." Current Pharmaceutical Biotechnology 22, no. 1 (December 31, 2020): 136–49. http://dx.doi.org/10.2174/1389201021666201229110625.

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: Medicinal plants produce a diverse group of phytocompounds like anthraquinones, alkaloids, anthocyanins, flavonoids, saponins, and terpenes which are used in pharmaceutical, perfume, cosmetics, dye and flavor industries. Commercial source of these metabolites is field-grown plants, which are generally influenced by seasonal changes. Biotechnology possesses a significant role in production of high-value secondary metabolites. By incorporating biotechnological methods, it is feasible to manage biosynthetic pathways of the plant to enhance phytocompound production that is of pharmaceutical interest. Plant cell suspension, shoot, adventitious root and hairy root culture are considered as alternative methods for important bioactive compound production. These methods are controllable, sustainable and overcome several inconveniences for large scale secondary metabolites production. At present research on hairy root culture for valuable bioactive compound production has gained a lot of attention. Agrobacterium rhizogenes is an agent which causes hairy root disease in a plant and this leads to the neoplastic growth of root which is characterized by higher growth rate and genetic stability. Various studies explore the hairy root culture for production of a wide range of bioactive compounds. Scale-up of hairy root culture using bioreactors has provided an opportunity to enhance bioactive compound production at the commercial level. The present review discusses the role of hairy root culture in the production of valuable bioactive compounds, the effect of culture parameters on bioactive compound production and bioreactor applications.

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Subramaniam, Shonia, Kanga Rani Selvaduray, and Ammu Kutty Radhakrishnan. "Bioactive Compounds: Natural Defense Against Cancer?" Biomolecules 9, no. 12 (November 21, 2019): 758. http://dx.doi.org/10.3390/biom9120758.

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Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, myricetin, geraniin and tocotrienols (T3) to provide an overview on some of the key findings that are related to this effect. The molecular mechanisms through which the active compounds may exert their anticancer properties in cell and animal-based studies also discussed.

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Forstinus Nwabor, Ozioma, and Sudarshan Singh. "A Systematic Review on Rhodomyrtus Tomentosa (Aiton) Hassk: A Potential Source of Pharmacological Relevant Bioactive Compounds with Prospects as Alternative Remedies in Varied Medical Conditions." International Journal of Pharmaceutical Sciences and Nanotechnology 15, no. 2 (April 30, 2022): 5875–91. http://dx.doi.org/10.37285/ijpsn.2022.15.2.7.

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Rhodomyrtus tomentosa is a medicinal plant with vast phytochemical diversity. Its major bioactive constituents include acylphloroglucinols, terpenoids, polyphenol, and flavonoids. Phytochemicals form the plant possess a wide range of biological activities and many are prospect as possible alternative compounds for the management of various health disorders. The review presents the antimicrobial mechanism of action of extracts from the plant and its derivative compounds as reported by published research articles. The search showed that 126 documents have been published on the chemical composition and bioactivities of the plant, in addition, 35 documents were published on rhodomyrtone, the major bioactive acylphloroglucinol from the plant. Retrieved data suggested that the plant is rich in bioactive phytochemicals including rhodomyrtone and its derivatives, Myricitrin, Piceatannol, quercetin, dihydromyricetin, kaempferol, and vitexin. Furthermore, antimicrobial assays indicated that the plant is a source of effective antimicrobial compounds with various mechanisms of action. This paper reviews current knowledge the chemical composition, pharmacology, and toxicology of the plant and its principal compound. The review is intended to inform scientists with interested in drug development on the excellent qualities of the plant and to encourage further research aimed at shedding light on its medical relevance, biocompatibility, pharmacology, and pharmacokinetics.

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Sharma, Nidhi, and Widhi Dubey. "DETERMINATION OF VOLATILE BIOACTIVE COMPOUNDS FROM EXTRACTS OF BAEL (AEGLE MARMELOS) PLANT PARTS AND THEIR COMPARATIVE ANALYSIS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (March 1, 2018): 393. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23529.

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Objective: The main objective of this study is to determine the bioactive compounds from the extracts of wildly growing Aegle marmelos plant parts.Methods: A. marmelos root, stem, leaves, bark, fruit peel, and pulp were screened for the presence/absence of phytochemicals. Bioactive compounds in all the plant parts were analyzed by gas chromatography–mass spectrometry (GC/MS) analysis. For evaluation of bioactive compounds first, the column chromatography was done using various solvents and found that the methanolic extracts gave better elution and separation of compounds and hence used further for GC/MS analysis.Result: GC/MS analysis revealed chromatograms of methanol extract of A. marmelos plant parts, and all the plant parts were found to have a number of phytochemicals. Some compounds, namely, benzene, nitro-, benzenepropanoic acid, 3, 5-bis (1, 1-dimethylethyl)-4-hydroxy-, methyl ester, and tetradecene were found in all parts with a varying percentage. Phenol only found in the fruit of the plant with more percentage in fruit peel (4.38%) than in fruit pulp (0.58%). Dibutyl phthalate is the major compound found in Aegle root (10.43%), fruit peel (34.56%), and pulp (13.18%). Other important compounds such as coumarin (2H-1-Benzopyran-2-one, 7-[(3,7-dimethyl-2,6-octadienyl)oxy]-, (E)-), skimmianine (Furo[2,3-b] quinoline, 4,7,8-trimethoxy-), and cyclobarbital were found in plant root.Conclusion: After the GC/MS analysis, it was concluded that all the parts of this wildly growing plant contain a significant amount of pharmaceutically important compounds.

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Chen, Xinyu, Shifeng Pan, Fei Li, Xinyu Xu, and Hua Xing. "Plant-Derived Bioactive Compounds and Potential Health Benefits: Involvement of the Gut Microbiota and Its Metabolic Activity." Biomolecules 12, no. 12 (December 13, 2022): 1871. http://dx.doi.org/10.3390/biom12121871.

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The misuse and abuse of antibiotics in livestock and poultry seriously endanger both human health and the continuously healthy development of the livestock and poultry breeding industry. Plant-derived bioactive compounds (curcumin, capsaicin, quercetin, resveratrol, catechin, lignans, etc.) have been widely studied in recent years, due to their extensive pharmacological functions and biological activities, such as anti-inflammatory, antioxidant, antistress, antitumor, antiviral, lowering blood glucose and lipids, and improving insulin sensitivity. Numerous studies have demonstrated that plant-derived bioactive compounds are able to enhance the host’s ability to resist or diminish diseases by regulating the abundance of its gut microbiota, achieving great potential as a substitute for antibiotics. Recent developments in both humans and animals have also highlighted the major contribution of gut microbiota to the host’s nutrition, metabolism, immunity, and neurological functions. Changes in gut microbiota composition are closely related to the development of obesity and can lead to numerous metabolic diseases. Mounting evidence has also demonstrated that plant-derived bioactive compounds, especially curcumin, can improve intestinal barrier function by regulating intestinal flora. Furthermore, bioactive constituents can be also directly metabolized by intestinal flora and further produce bioactive metabolites by the interaction between the host and intestinal flora. This largely enhances the protective effect of bioactive compounds on the host intestinal and whole body health, indicating that the bidirectional regulation between bioactive compounds and intestinal flora has great application potential in maintaining the host’s intestinal health and preventing or treating various diseases. This review mainly summarizes the latest research progress in the bioregulation between gut microbiota and plant-derived bioactive compounds, together with its application potential in humans and animals, so as to provide theoretical support for the application of plant-derived bioactive compounds as new feed additives and potential substitutes for antibiotics in the livestock and poultry breeding industry. Overall, based on this review, it can be concluded that plant-derived bioactive compounds, by modulating gut microbiota, hold great promise toward the healthy development of both humans and animal husbandry.

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Kolli, Deepti, Karteek Rao Amperyani, and Umadevi Parimi. "PHYTOCHEMICAL ANALYSIS AND IN VITRO GENOTOXICITY, CYTOTOXICITY, ANTIOXIDANT, ANTIMICROBIAL, ANTIOBESITY ACTIVITY OF MORINDA TINCTORIA ROXB." Indian Drugs 59, no. 03 (June 1, 2022): 31–40. http://dx.doi.org/10.53879/id.59.03.12238.

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The medicinal plant Morinda tinctoria Roxb. is used in the treatment of various diseases traditionally. Report on bioactive evaluation of M. tinctoria Roxb. has led us to the phytochemical examination of M. tinctoria leaves. Our objective was to isolate compounds form M. tinctoria Roxb. and characterize each compound. The isolated compounds were tested for antioxidant, antimicrobial, antiobesity, cytotoxicity and genotoxicity properties. For this work, we have chosen solvents with increasing polarities. Hexane, chloroform, ethyl acetate and methanol were used in this study. The solvent extracts were analyzed using column chromatography and the isolated compounds were characterized using FTIR, 1 H NMR, 13C NMR and mass spectra. The constituents have been characterized and screened for in vitro antioxidant, antimicrobial, antiobesity, cytotoxicity and genotoxicity properties. Nine bioactive compounds were isolated and identified: palmitic acid, fucoxanthine, broussin, isoliquiritigenin, cynarin, gallic acid, β-sitosterol, quercetin and oleuropein. The results thus indicate conclusively that M. tinctoria leaves possess various potent bioactive compounds and is therefore recommended as a plant of phytopharmaceutical importance.

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Nogueira, Gislaine Ferreira, Rafael Augustus de Oliveira, José Ignacio Velasco, and Farayde Matta Fakhouri. "Methods of Incorporating Plant-Derived Bioactive Compounds into Films Made with Agro-Based Polymers for Application as Food Packaging: A Brief Review." Polymers 12, no. 11 (October 28, 2020): 2518. http://dx.doi.org/10.3390/polym12112518.

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Plastic, usually derived from non-renewable sources, is among the most used materials in food packaging. Despite its barrier properties, plastic packaging has a recycling rate below the ideal and its accumulation in the environment leads to environmental issues. One of the solutions approached to minimize this impact is the development of food packaging materials made from polymers from renewable sources that, in addition to being biodegradable, can also be edible. Different biopolymers from agricultural renewable sources such as gelatin, whey protein, starch, chitosan, alginate and pectin, among other, have been analyzed for the development of biodegradable films. Moreover, these films can serve as vehicles for transporting bioactive compounds, extending their applicability as bioactive, edible, compostable and biodegradable films. Biopolymer films incorporated with plant-derived bioactive compounds have become an interesting area of research. The interaction between environment-friendly biopolymers and bioactive compounds improves functionality. In addition to interfering with thermal, mechanical and barrier properties of films, depending on the properties of the bioactive compounds, new characteristics are attributed to films, such as antimicrobial and antioxidant properties, color and innovative flavors. This review compiles information on agro-based biopolymers and plant-derived bioactive compounds used in the production of bioactive films. Particular emphasis has been given to the methods used for incorporating bioactive compounds from plant-derived into films and their influence on the functional properties of biopolymer films. Some limitations to be overcome for future advances are also briefly summarized. This review will benefit future prospects for exploring innovative methods of incorporating plant-derived bioactive compounds into films made from agricultural polymers.

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Koistinen, Ville Mikael, Andreia Bento da Silva, László Abrankó, Dorrain Low, Rocio Garcia Villalba, Francisco Tomás Barberán, Rikard Landberg, et al. "Interlaboratory Coverage Test on Plant Food Bioactive Compounds and their Metabolites by Mass Spectrometry-Based Untargeted Metabolomics." Metabolites 8, no. 3 (August 24, 2018): 46. http://dx.doi.org/10.3390/metabo8030046.

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Bioactive compounds present in plant-based foods, and their metabolites derived from gut microbiota and endogenous metabolism, represent thousands of chemical structures of potential interest for human nutrition and health. State-of-the-art analytical methodologies, including untargeted metabolomics based on high-resolution mass spectrometry, are required for the profiling of these compounds in complex matrices, including plant food materials and biofluids. The aim of this project was to compare the analytical coverage of untargeted metabolomics methods independently developed and employed in various European platforms. In total, 56 chemical standards representing the most common classes of bioactive compounds spread over a wide chemical space were selected and analyzed by the participating platforms (n = 13) using their preferred untargeted method. The results were used to define analytical criteria for a successful analysis of plant food bioactives. Furthermore, they will serve as a basis for an optimized consensus method.

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Salar, Francisco J., Vicente Agulló, Raúl Domínguez-Perles, and Cristina García-Viguera. "Influence of Sweeteners (Sucrose, Sucralose, and Stevia) on Bioactive Compounds in a Model System Study for Citrus–Maqui Beverages." Foods 11, no. 15 (July 29, 2022): 2266. http://dx.doi.org/10.3390/foods11152266.

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Recently, new formulations of beverages with low sugar and high bioactive compound contents are being demanded because of their association with metabolic health. However, the sweeteners’ influences on the bioactive compounds remain underexplored. In this sense, this work aims to evaluate the interactions between different bioactive compounds such as flavonoids, vitamin C, and sweeteners (sucrose, stevia, and sucralose) in a functional citrus–maqui beverage. For this purpose, the phytochemical behavior was studied, in model system solutions, during one-month storage at 4 °C. The results obtained corroborated previous descriptions of the interactions between these compounds. However, when studying the bioactives in the model solutions, the loss of flavanones in the citrus solution increased up to 29%, while anthocyanin losses decreased to 27%. The vitamin C losses ranged from 100% (beverage) to 46% (ascorbic acid solution). Regardless, an influence of the sweeteners was observed. Sucrose reduced the anthocyanin and flavanone losses in both model solutions and the beverage, while sucralose increased flavanone loss. Finally, all sweeteners increased vitamin C degradation (up to 75%) when compared to the model solution. In conclusion, sweeteners added to beverages should be taken into account, depending on the bioactive compounds that should be preserved during storage.

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Doria, Enrico, Daniela Buonocore, Antonio Marra, Valeria Bontà, Andrea Gazzola, Maurizia Dossena, Manuela Verri, and Cinzia Calvio. "Bacterial-Assisted Extraction of Bioactive Compounds from Cauliflower." Plants 11, no. 6 (March 18, 2022): 816. http://dx.doi.org/10.3390/plants11060816.

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The market for nutraceutical molecules is growing at an impressive pace in all Western countries. A convenient source of bioactive compounds is found in vegetable waste products, and their re-use for the recovery of healthy biomolecules would increase the sustainability of the food production system. However, safe, cheap, and sustainable technologies should be applied for the recovery of these beneficial molecules, avoiding the use of toxic organic solvents or expensive equipment. The soil bacterium Bacillus subtilis is naturally endowed with several enzymes targeting complex vegetable polymers. In this work, a raw bacterial culture supernatant was used to assist in the extraction of bioactives using isothermal pressurization cycles. Besides a wild-type Bacillus subtilis strain, a new strain showing increased secretion of cellulases and xylanases, pivotal enzymes for the digestion of the plant cell wall, was also used. Results indicate that the recovery of compounds correlates with the amount of cellulolytic enzymes applied, demonstrating that the pretreatment with non-purified culture broth effectively promotes the release of bioactives from the vegetable matrix. Therefore, this approach is a valid and sustainable procedure for the recovery of bioactive compounds from food waste.

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Folmer, Florence, Umesh Basavaraju, Marcel Jaspars, Georgina Hold, Emad El-Omar, Mario Dicato, and Marc Diederich. "Anticancer effects of bioactive berry compounds." Phytochemistry Reviews 13, no. 1 (September 5, 2013): 295–322. http://dx.doi.org/10.1007/s11101-013-9319-z.

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Kaur, Harpreet. "Boerhaavia Diffusa: Bioactive Compounds and Pharmacological Activities." Biomedical and Pharmacology Journal 12, no. 04 (November 27, 2019): 1675–82. http://dx.doi.org/10.13005/bpj/1797.

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Boerhaavia diffusa belonging to family Nyctaginaceae has a wide distribution, occurring on major part of the globe. It is known as Punarnava in Ayurveda and is a main ingredient in many formulations of Ayurveda. It is used as traditional medicine by indigenous people of many countries in the world for its protective role against inflammation, prostatic hyperplasia, diabetes, cancer, gastrointestinal problems, arthritis etc. The whole plant contains numerous bioactive compounds which are responsible for its pharmacological activities. Experiments are being done to evaluate full potential of the plant. The present review focuses on the bioactive compounds and pharmacological activities of B. diffusa. The study is carried out with the aim that it will be helpful for more research and wide acceptance of B. diffusa so that the plant which till now was used by indigenous people for its medicinal properties will become an ingredient of major mainstream medicines used to treat chronic human ailments.

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Shoaib, Shoaib, Mohammad Azam Ansari, Adel Al Fatease, Awaji Y. Safhi, Umme Hani, Roshan Jahan, Mohammad N. Alomary, et al. "Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection." Pharmaceutics 15, no. 3 (February 23, 2023): 749. http://dx.doi.org/10.3390/pharmaceutics15030749.

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Neurodegenerative disorders encompass a wide range of pathological conditions caused by progressive damage to the neuronal cells and nervous-system connections, which primarily target neuronal dysfunction and result in problems with mobility, cognition, coordination, sensation, and strength. Molecular insights have revealed that stress-related biochemical alterations such as abnormal protein aggregation, extensive generation of reactive oxygen and nitrogen species, mitochondrial dysfunction, and neuroinflammation may lead to damage to neuronal cells. Currently, no neurodegenerative disease is curable, and the available standard therapies can only provide symptomatic treatment and delay the progression of the disease. Interestingly, plant-derived bioactive compounds have drawn considerable attention due to their well-established medicinal properties, including anti-apoptotic, antioxidant, anti-inflammatory, anticancer, and antimicrobial properties, as well as neuroprotective, hepatoprotective, cardioprotective, and other health benefits. Plant-derived bioactive compounds have received far more attention in recent decades than synthetic bioactive compounds in the treatment of many diseases, including neurodegeneration. By selecting suitable plant-derived bioactive compounds and/or plant formulations, we can fine tune the standard therapies because the therapeutic efficacy of the drugs is greatly enhanced by combinations. A plethora of in vitro and in vivo studies have demonstrated plant-derived bioactive compounds’ immense potential, as proven by their capacity to influence the expression and activity of numerous proteins implicated in oxidative stress, neuroinflammation, apoptosis, and aggregation. Thus, this review mostly focuses on the antioxidant, anti-inflammatory, anti-aggregation, anti-cholinesterase, and anti-apoptotic properties of several plant formulations and plant-derived bioactive compounds and their molecular mechanisms against neurodegenerative disorders.

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Ávila-Juárez, Luciano, and Herminio Miranda-Rodríguez. "Variations in Bioactive Content in Different Tomato Trusses due to Elicitor Effects." Journal of Chemistry 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/2736070.

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The tomato fruit is rich in bioactive compounds with antioxidant activity, the levels of which can vary over time in response to biotic and abiotic factors, including the application of elicitors. We investigated the effects of foliar spray of methyl jasmonate (MeJ), salicylic acid (SA), nitric oxide (NO), and hydrogen peroxide (H2O2) on tomato plants every 15 days until the end of cultivation. We measured the levels of bioactive compounds, antioxidant activity, and physiological parameters in three distinct trusses. With the exception of plant length, the elicitors had no effects on physiological parameters, whereas they did have an effect on lycopene content, bioactive compound levels, and antioxidant activity in the three sampled trusses. A strong correlation between bioactive compounds and antioxidant activity was found for the elicitors, particularly MeJ. Our results indicate that certain bioactive compounds and their antioxidant activities vary not only between trusses but also based on the specific elicitor used.

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Stefanos, Leontopoulos, Chatzitheodorou Vasilios, and Skenderidis Prodromos. "Recent studies on Polyphenols: Extraction technologies and prospects." International Journal of Agricultural Science and Food Technology 8, no. 4 (November 22, 2022): 277–83. http://dx.doi.org/10.17352/2455-815x.000178.

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Polyphenols constitute a group of the most important bioactive compounds widely represented naturally in many plant species. Fresh plant tissues, plant residues, and agro-wastes contain consequent amounts of polyphenolic compounds. In recent years, there is a developing interest in utilizing these bioactive compounds for nutraceutical and pharmaceutical applications due to their beneficial effects on human health and their potential in improving the quality of food. However, their effectiveness is depending on many factors such as the extraction technique, the plant tissue, and species origin, environmental factors, the solvent used for the extraction, etc. The purpose of this critical review is to address and give an insight into the latest review and research articles regarding extraction methods and highlights the prospects of bioactive compounds found in several plant tissues.

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Takhellambam Chanu Machathoibi and Asem Surindro Singh. "Medicinal plant derived drugs and their treatment for human diseases like cancer: A review." World Journal of Advanced Research and Reviews 16, no. 2 (November 30, 2022): 580–85. http://dx.doi.org/10.30574/wjarr.2022.16.2.1128.

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Several medicinal plants have been popularly known and widely used to cure various diseases throughout the planet since ancient times. Various types of plants have been found to cure different kinds of human diseases effectively. Several research are focused on finding specific compounds from medicinal plants that have effective medicinal properties in curing human diseases. Finding the bioactive compounds specific to a disease could help in understanding the properties of the compound towards a disease and thereby its application with more precision and convenience. Understanding the characteristics of the bioactive compound can help in large scale production to be commercially available globally as per the demands and it can direct to design for synthetic production. It will benefit in several ways in terms of reducing the amount of intake as lesser amount would be needed, reducing restriction of availability as the plant grow at certain environmental conditions and overcome inconvenience of transport/portability and preservation and unseasonal availability of the plant. In this short review, plant derived natural products; anticancer properties of cumin from Curcuma longa subsp and the importance of medicinal plants such as Cronton caudatus subsp are highlighted.

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Verma, Vijay C., Ravindra N. Kharwar, and Gary A. Strobel. "Chemical and Functional Diversity of Natural Products from Plant Associated Endophytic Fungi." Natural Product Communications 4, no. 11 (November 2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401114.

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This review describes examples of naturally occurring bioactive compounds obtained from fungal endophytes from various host plants. The main topics addressed are sources, identification, biological activity, biosynthesis, and ecological and chemosystematic significance of those bioactive compounds whose sources were well defined.

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Lu, Jiang-hai, Xiao-ping Pu, Yan-yun Li, Yu-ying Zhao, and Guang-zhong Tu. "Bioactive Phenylethanoid Glycosides from Buddleia lindleyana." Zeitschrift für Naturforschung B 60, no. 2 (February 1, 2005): 211–14. http://dx.doi.org/10.1515/znb-2005-0214.

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Nine phenylethanoid glycosides were isolated from Buddleia lindleyana. On the basis of spectral analyses, their structures were elucidated to be acteoside (1), echinacoside (2), citanoside A (3), leucosceptoside A (4), leucosceptoside B (5), pedicularioside A (6), isoacteoside (7), arenariside (8), and a new compound named buddleoside A (9). The eight known compounds were isolated from this plant for the first time. The neuroprotective effects of compounds 1 (acteoside), 5, 6, 8 and 9 on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell death in mesencenphalic neurons were investigated. Mesencenphalic neurons treated with MPP+ underwent cell death as determined by MTT assay. Simultaneous treatment with the phenylethanoid glycosides markedly attenuated MPP+- induced cytotoxicity.

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Sharifi-Rad, Javad, Célia F. Rodrigues, Farukh Sharopov, Anca Oana Docea, Aslı Can Karaca, Mehdi Sharifi-Rad, Derya Kahveci Karıncaoglu, et al. "Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds." International Journal of Environmental Research and Public Health 17, no. 7 (March 30, 2020): 2326. http://dx.doi.org/10.3390/ijerph17072326.

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Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

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Chemjong, Menjo, Nirupa Kumari Yadav, Aarzoo ., Ankita Sarkate, and Mudasir Yaqoob. "BIOACTIVE COMPOUNDS, TYPES, STABILITY AND HEALTH BENEFITS." PLANT ARCHIVES 21, Suppliment-1 (January 15, 2021): 1863–69. http://dx.doi.org/10.51470/plantarchives.2021.v21.s1.300.

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Bouzroud, Sarah, Ezzouhra El Maaiden, Mansour Sobeh, Nawal Merghoub, Hassan Boukcim, Lamfeddal Kouisni, and Youssef El Kharrassi. "Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects." International Journal of Molecular Sciences 24, no. 2 (January 11, 2023): 1397. http://dx.doi.org/10.3390/ijms24021397.

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Plants are the main source of bioactive compounds that can be used for the formulation of cosmetic products. Plant extracts have numerous proven health benefits, among which are anti-ageing and skin-care properties. However, with the increased demand for plant-derived cosmetic products, there is a crucial prerequisite for establishing alternative approaches to conventional methods to ensure sufficient biomass for sustainable production. Plant tissue culture techniques, such as in vitro root cultures, micropropagation, or callogenesis, offer the possibility to produce considerable amounts of bioactive compounds independent of external factors that may influence their production. This production can also be significantly increased with the implementation of other biotechnological approaches such as elicitation, metabolic engineering, precursor and/or nutrient feeding, immobilization, and permeabilization. This work aimed to evaluate the potential of biotechnological tools for producing bioactive compounds, with a focus on bioactive compounds with anti-ageing properties, which can be used for the development of green-label cosmeceutical products. In addition, some examples demonstrating the use of plant tissue culture techniques to produce high-value bioactive ingredients for cosmeceutical applications are also addressed, showing the importance of these tools and approaches for the sustainable production of plant-derived cosmetic products.

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Ivanescu, Bianca, Cristina Lungu, Laurian Vlase, Ana Maria Gheldiu, Cristina Grigorescu, and Andreia Corciova. "Bioactive Compounds from Artemisia campestris L. Subsp. Campestris." Revista de Chimie 69, no. 11 (December 15, 2018): 3076–81. http://dx.doi.org/10.37358/rc.18.11.6686.

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Artemisia campestris L. (field wormwood) is a known medicinal plant used mainly in Asian medicine and most often overlooked in the western world, despite its cosmopolitan distribution. The aim of this study was to investigate the phytochemical composition of A. campestris from Romanian spontaneous flora in order to determine the bioactive molecules and to assess the antioxidant effect of the plant extract. For this purpose, we applied LC-MS methods for the analysis of phytosterols and polyphenols and developed new methods for the analysis of methoxylated flavones and sesquiterpene lactones, specific compounds in Artemisia genus. The paper is the first to report the concentration of these compounds in the indigenous plant and also to identify some new compounds, previously not reported in this species, such as eupatorin, casticin, and acacetin. The plant extract showed significant antioxidant activity in both radical scavenging and reducing power assay, well correlated with the polyphenolic profile.

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Journal articles on the topic 'Plant bioactive compounds'

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