Journal articles: 'Plant Based Pharmaceutical'

1

Pal, Rashmi Saxena, Yogendra Pal, Ankita Wal, and Pranay Wal. "Current Review on Plant based Pharmaceutical Excipients." Open Medicine Journal 6, no. 1 (February 19, 2019): 1–5. http://dx.doi.org/10.2174/1874220301906010001.

Full text

Abstract:

Background: Plants act as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this, they act as excellent pharmaceutical aids as well as excipients. Objective: An effort has been made for the complete study of plants under different categories of plant-based thickeners, emulsifiers, suspenders, binders, etc. Materials and Methods: The herbs were differentiated on the basis of their role as flavoring, sweetening, colouring, gelling, thickening, emulsifying, suspending and binding agents. Results: The use of natural excipients to impart the goodness of natural bioactive agents has been hampered by synthetic materials. However, advantages offered by these natural excipients are enormous as being non-toxic, affordable and easily available. The activity of the excipients partly determines the quality of medicines. Conclusion: The herbal excipients act better in many ways when compared to their synthetic substitutes.

APA, Harvard, Vancouver, ISO, and other styles

2

Norikane, Joey H. "The Potential of LEDs in Plant-based Bio-pharmaceutical Production." HortScience 50, no. 9 (September 2015): 1289–92. http://dx.doi.org/10.21273/hortsci.50.9.1289.

Full text

Abstract:

Fraunhofer USA, Inc. Center for Molecular Biotechnology (FhCMB) has pioneered a transient plant-based biopharmaceutical platform to produce vaccines and therapeutics quickly and cost-effectively. Using this platform, plants are grown hydroponically in a controlled environment. The plants are vacuum infiltrated with a recombinant Agrobacteria carrying a plant viral–based hybrid vector and returned to a controlled environment for the target protein to be produced in infiltrated plant tissue. When target protein levels peak in leaf tissue, the plants are harvested and homogenized, extract is clarified and the target protein is purified. There are multiple opportunities in this system for light-emitting diodes (LEDs) to be applied to optimize biomass accumulation and the production of target proteins. There is potential to develop specific photo-recipes to optimize plant growth and target protein production.

APA, Harvard, Vancouver, ISO, and other styles

3

Arora, Saroj, Davinder Singh, Ankita Rajput, Astha Bhatia, Avinash Kumar, Harneetpal Kaur, Palvi Sharma, et al. "Plant-Based Polysaccharides and their Health Functions." Functional Foods in Health and Disease 11, no. 4 (April 14, 2021): 179. http://dx.doi.org/10.31989/ffhd.v11i4.773.

Full text

Abstract:

Plants are valuable source of polysaccharides that make a large portion of our daily diet. These are natural polymers that are essential to sustain life. They provide high-value nutrition and positively help the immune system and improve the digestive properties. They also help in the elimination of toxic by-products from the human body. Polysaccharides and human health are inextricably linked and intertwined. These are also important components of the cell wall that provides its strength and integrity. Due to their indispensable role in human health, it is very important to know the different modifications and loss of nutritional value during the processing of plant material. Nowadays, these plant-based polysaccharides are used for diverse applications including wound dressing, drug delivery, laxative, cosmetic and pharmaceutical preparations. As an emerging area of plant-based medicines to reduce the side effects of synthetic sources, these polysaccharides are used to enhance the immunogenic response against a specific antigen. This review envisages some important polysaccharides (e.g. mucilages and gums, glycosamine glycans and chitin/chitosan) and their medical, cosmetic, and pharmaceutical applications, with emphasis on the relationship between their structure and function.Keywords: Polysaccharides; Nutrition; Health Functions; Cosmetics; Vaccine; Nutraceuticals

APA, Harvard, Vancouver, ISO, and other styles

4

Lakerveld, Richard, Brahim Benyahia, Richard D. Braatz, and Paul I. Barton. "Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant." AIChE Journal 59, no. 10 (April 25, 2013): 3671–85. http://dx.doi.org/10.1002/aic.14107.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Jensen, Michael K. "New scalable strategy for challenging plant-based medicines." EU Research 32, Autumn 2022 (2022): 17–19. http://dx.doi.org/10.56181/uysc2182.

Full text

Abstract:

A European consortium working on the MIAMi project is using yeast to support sustainable, scalable production of complex chemical compounds in rare plants, to harness their valuable healthcare and pharmaceutical properties. We speak to Dr. Michael Krogh Jensen, Group Leader & Senior Researcher from the Technical University of Denmark.

APA, Harvard, Vancouver, ISO, and other styles

6

Kaloudas, Dimitrios, and Robert Penchovsky. "Plant-Derived Compounds and Their Potential Role in Drug Development." International Journal of Biomedical and Clinical Engineering 7, no. 1 (January 2018): 53–66. http://dx.doi.org/10.4018/ijbce.2018010104.

Full text

Abstract:

This article describes how with the development of biotechnology, plants have gained again a prominent place as a relatively inexpensive source for the creation of recombinant pharmaceuticals. Plant-derived compounds have started playing a major role in the pharmaceutical industry with many plant-based products to have found their way in drugs and chemicals used for the treatment of different diseases and their symptoms. Plant-derived compounds have been tested for the treatment of several types of cancer, Central Nervous System disorders, as enhancers during chemotherapy and as vessels for targeted drug delivery. Genetically modified plant cells have been recruited for the production of therapeutic agencies as well as in the creation of expression systems for virus-like particles that could be used as vaccines. Moreover, microRNAs mimicking the plant ones have the ability to inhibit tumors in mammalian cells. This review describes plant-derived compounds and their properties as potential therapeutic agents and precursors for the development of novel drugs in the pharmaceutical industry.

APA, Harvard, Vancouver, ISO, and other styles

7

LeBlanc, Zacharie, Peter Waterhouse, and Julia Bally. "Plant-Based Vaccines: The Way Ahead?" Viruses 13, no. 1 (December 22, 2020): 5. http://dx.doi.org/10.3390/v13010005.

Full text

Abstract:

Severe virus outbreaks are occurring more often and spreading faster and further than ever. Preparedness plans based on lessons learned from past epidemics can guide behavioral and pharmacological interventions to contain and treat emergent diseases. Although conventional biologics production systems can meet the pharmaceutical needs of a community at homeostasis, the COVID-19 pandemic has created an abrupt rise in demand for vaccines and therapeutics that highlight the gaps in this supply chain’s ability to quickly develop and produce biologics in emergency situations given a short lead time. Considering the projected requirements for COVID-19 vaccines and the necessity for expedited large scale manufacture the capabilities of current biologics production systems should be surveyed to determine their applicability to pandemic preparedness. Plant-based biologics production systems have progressed to a state of commercial viability in the past 30 years with the capacity for production of complex, glycosylated, “mammalian compatible” molecules in a system with comparatively low production costs, high scalability, and production flexibility. Continued research drives the expansion of plant virus-based tools for harnessing the full production capacity from the plant biomass in transient systems. Here, we present an overview of vaccine production systems with a focus on plant-based production systems and their potential role as “first responders” in emergency pandemic situations.

APA, Harvard, Vancouver, ISO, and other styles

8

Adekanmi, D. G., and A. E. Olowofoyeku. "African Star Apple: Potentials and Application of Some Indigenous Species in Nigeria." Journal of Applied Sciences and Environmental Management 24, no. 8 (September 9, 2020): 1307–14. http://dx.doi.org/10.4314/jasem.v24i8.1.

Full text

Abstract:

Many research in food and pharmaceuticals are focused on the use of materials as close to nature as possible to limit exposure to harmful synthetic substances. Alternatives are being sought for popular plant based materials leading to increased attention to underutilized plants and creating ripple effects in agriculture, agribusiness, health and pharmaceuticals. A plant that is attaining prominence in Nigeria and in the rain forests of West Africa is the African Star Apple. The plant is best known for the juicy pulp of its fruit but the traditional therapeutic use of parts of the plants are also common. Some authors have investigated and documented some benefits obtained from its leaves, stem, root and fruits. This paper focuses on the features, food and pharmaceutical potentials of the oil, flour, extracts and gum form the African Star Apple. Its fruit is rich in minerals and antioxidant while extracts from various parts of the plant have good antimicrobial and antifungal properties. The review also reveals that the AfricanStar Apple has many potential food and pharmaceutical applications that are yet to be explored. Keywords: African Star Apple, Chrysophyllum albidum, Phytochemicals, Gum, Extracts.

APA, Harvard, Vancouver, ISO, and other styles

9

Chaiyana, Wantida, Kiattisak Saeio, Wim E. Hennink, and Siriporn Okonogi. "Characterization of potent anticholinesterase plant oil based microemulsion." International Journal of Pharmaceutics 401, no. 1-2 (November 2010): 32–40. http://dx.doi.org/10.1016/j.ijpharm.2010.09.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Shahriari, Amir Ghaffar, and Maziar Habibi-Pirkoohi. "Plant-Based Recombinant Vaccine: Fact or Fiction?" Galen Medical Journal 6, no. 4 (December 29, 2017): 268–80. http://dx.doi.org/10.31661/gmj.v6i4.792.

Full text

Abstract:

In the era of recombinant DNA technology, production of recombinant vaccines in green plants has emerged as an effective approach addressing the problems of traditional vaccine production. Various antigens expressed in different plant species have been so far tested for the production of efficient oral vaccines against human and livestock diseases. However, recombinant vaccines have not yet found a prominent place in pharmaceutical market. There are still many challenges to be addressed to pave the road for commercial production of plant-based recombinant vaccines. Regarding increasing growth in laboratory studies and field trials for development of plant-based vaccines, this review paper provides a comprehensive overview on the topic of plant-derived vaccines and related issues. [GMJ.2017;6(4):268-80] DOI:10.22086/gmj.v6i3.792

APA, Harvard, Vancouver, ISO, and other styles

11

Bravo-Vázquez, Luis Alberto, Erick Octavio Mora-Hernández, Alma L. Rodríguez, Padmavati Sahare, Anindya Bandyopadhyay, Asim K. Duttaroy, and Sujay Paul. "Current Advances of Plant-Based Vaccines for Neurodegenerative Diseases." Pharmaceutics 15, no. 2 (February 20, 2023): 711. http://dx.doi.org/10.3390/pharmaceutics15020711.

Full text

Abstract:

Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins that induce neurodegeneration in NDDs have been designed in the last decades. In this context, due to unprecedented advances in genetic engineering techniques and molecular farming technology, pioneering plant-based immunogenic antigen expression systems have been developed aiming to offer reliable alternatives to deal with important NDDs, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Diverse reports have evidenced that plant-made vaccines trigger significant immune responses in model animals, supported by the production of antibodies against the aberrant proteins expressed in the aforementioned NDDs. Moreover, these immunogenic tools have various advantages that make them a viable alternative for preventing and treating NDDs, such as high scalability, no risk of contamination with human pathogens, cold chain free production, and lower production costs. Hence, this article presents an overview of the current progress on plant-manufactured vaccines for NDDs and discusses its future prospects.

APA, Harvard, Vancouver, ISO, and other styles

12

Sîrbu, Daniel, and Cristina Elena Băișan. "Lean Manufacturing Benefits in a Pharmaceutical Production Plant." Applied Mechanics and Materials 657 (October 2014): 991–95. http://dx.doi.org/10.4028/www.scientific.net/amm.657.991.

Full text

Abstract:

Various Lean developments and related matters have been accomplished [1-7, etc.]. This paper attempts to stress on several main methods of Lean culture applied in Zentiva Romania pharmaceuticals production plant, such as: +QDCI, SMED, 5S, etc. A systematic analysis and development of adequate actions for solving the considered critical problem have been accomplished, based on the Lean manufacturing principles. The Lean tools applied in Zentiva Romania are being used to identify and eliminate wasteful steps in products and processes, increase the manufacturing capability and reduce cost, in order to remain competitive on the market, deal with fast transfers of new products and technologies, etc. An important result is the emphasize of the Lean methods implementation benefits, such as greater productivity, improved lead times, elimination of waste, innovation stimulation, safer work environment, better monitoring of the outputs etc.

APA, Harvard, Vancouver, ISO, and other styles

13

Amiri, Mohammad Sadegh, Vahideh Mohammadzadeh, Mohammad Ehsan Taghavizadeh Yazdi, Mahmood Barani, Abbas Rahdar, and George Z. Kyzas. "Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review." Molecules 26, no. 6 (March 22, 2021): 1770. http://dx.doi.org/10.3390/molecules26061770.

Full text

Abstract:

Gums are carbohydrate biomolecules that have the potential to bind water and form gels. Gums are regularly linked with proteins and minerals in their construction. Gums have several forms, such as mucilage gums, seed gums, exudate gums, etc. Plant gums are one of the most important gums because of their bioavailability. Plant-derived gums have been used by humans since ancient times for numerous applications. The main features that make them appropriate for use in different applications are high stabilization, viscosity, adhesive property, emulsification action, and surface-active activity. In many pharmaceutical formulations, plant-based gums and mucilages are the key ingredients due to their bioavailability, widespread accessibility, non-toxicity, and reasonable prices. These compete with many polymeric materials for use as different pharmaceuticals in today’s time and have created a significant achievement from being an excipient to innovative drug carriers. In particular, scientists and pharmacy industries around the world have been drawn to uncover the secret potential of plant-based gums and mucilages through a deeper understanding of their physicochemical characteristics and the development of safety profile information. This innovative unique class of drug products, useful in advanced drug delivery applications, gene therapy, and biosynthesis, has been developed by modification of plant-based gums and mucilages. In this review, both fundamental and novel medicinal aspects of plant-based gums and mucilages, along with their capacity for pharmacology and nanomedicine, were demonstrated.

APA, Harvard, Vancouver, ISO, and other styles

14

Newman, Erin B. "Earth's Vanishing Medicine Cabinet: Rain Forest Destruction and Its Impact on the Pharmaceutical Industry." American Journal of Law & Medicine 20, no. 4 (1994): 479–501. http://dx.doi.org/10.1017/s0098858800006869.

Full text

Abstract:

Todos tem direito ao meio ambiente ecologicamente equilibrado. Everyone has the right to an ecologically balanced environment. In 1988, the Brazilian Constitutional Assembly incorporated this imperative into the Brazilian Constitution as part of a chapter on environmental protection. After hundreds of years of environmental ignorance, our planet's inhabitants have experienced a growth of environmental awareness. One global environmental tragedy garnering substantial recent attention is the depletion of the planet's tropical rain forests. In addition to eternally altering the human environment, rain forest destruction poses a serious threat to both the pharmaceutical industry and individuals in need of medical care. A substantial portion of existing pharmaceuticals are plant-based and animal-based, and the pharmaceutical industry continues to explore additional species for medicinal potential, particularly in tropical regions. As mass deforestation of these areas forces countless species into extinction, specimens yet to be analyzed for their pharmaceutical potential will be eternally lost. As one noted conservationist explained, “Even severe pollution is reversible, but species extinction is irreversible.”

APA, Harvard, Vancouver, ISO, and other styles

15

Yaseneva, Polina, Paul Hodgson, Jacek Zakrzewski, Sebastian Falß, Rebecca E. Meadows, and Alexei A. Lapkin. "Continuous flow Buchwald–Hartwig amination of a pharmaceutical intermediate." Reaction Chemistry & Engineering 1, no. 2 (2016): 229–38. http://dx.doi.org/10.1039/c5re00048c.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Sokullu, Esen, Hoda Soleymani Abyaneh, and Marc A. Gauthier. "Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics." Pharmaceutics 11, no. 5 (May 3, 2019): 211. http://dx.doi.org/10.3390/pharmaceutics11050211.

Full text

Abstract:

Viruses have recently emerged as promising nanomaterials for biotechnological applications. One of the most important applications of viruses is phage display, which has already been employed to identify a broad range of potential therapeutic peptides and antibodies, as well as other biotechnologically relevant polypeptides (including protease inhibitors, minimizing proteins, and cell/organ targeting peptides). Additionally, their high stability, easily modifiable surface, and enormous diversity in shape and size, distinguish viruses from synthetic nanocarriers used for drug delivery. Indeed, several plant and bacterial viruses (e.g., phages) have been investigated and applied as drug carriers. The ability to remove the genetic material within the capsids of some plant viruses and phages produces empty viral-like particles that are replication-deficient and can be loaded with therapeutic agents. This review summarizes the current applications of plant viruses and phages in drug discovery and as drug delivery systems and includes a discussion of the present status of virus-based materials in clinical research, alongside the observed challenges and opportunities.

APA, Harvard, Vancouver, ISO, and other styles

17

Kambale, Espoir K., Joëlle Quetin-Leclercq, Patrick B. Memvanga, and Ana Beloqui. "An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations." Pharmaceutics 14, no. 10 (October 8, 2022): 2135. http://dx.doi.org/10.3390/pharmaceutics14102135.

Full text

Abstract:

Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.

APA, Harvard, Vancouver, ISO, and other styles

18

Elshafie, Hazem S., Ippolito Camele, and Amira A. Mohamed. "A Comprehensive Review on the Biological, Agricultural and Pharmaceutical Properties of Secondary Metabolites Based-Plant Origin." International Journal of Molecular Sciences 24, no. 4 (February 7, 2023): 3266. http://dx.doi.org/10.3390/ijms24043266.

Full text

Abstract:

Natural products are compounds produced by living organisms and can be divided into two main categories: primary (PMs) and secondary metabolites (SMs). Plant PMs are crucial for plant growth and reproduction since they are directly involved in living cell processes, whereas plant SMs are organic substances directly involved in plant defense and resistance. SMs are divided into three main groups: terpenoids, phenolics and nitrogen-containing compounds. The SMs contain a variety of biological capabilities that can be used as flavoring agents, food additives, plant-disease control, strengthen plant defenses against herbivores and, additionally, it can help plant cells to be better adapted to the physiological stress response. The current review is mainly focusing on certain key elements related to the significance, biosynthesis, classification, biochemical characterization and medical/pharmaceutical uses of the major categories of plant SMs. In addition, the usefulness of SMs in controlling plant diseases, boosting plant resistance and as potential natural, safe, eco-friendly substitutes for chemosynthetic pesticides were also reported in this review.

APA, Harvard, Vancouver, ISO, and other styles

19

Filatov, V. A., O. Y. Kulyak, and E. I. Kalenikova. "156 The development of plant-based pharmaceutical substance for treatment of seborrheic dermatitis." Journal of Investigative Dermatology 142, no. 12 (December 2022): S206. http://dx.doi.org/10.1016/j.jid.2022.09.166.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Abdelsalam, Ahmed M., Ahmed Somaida, Abdallah Mohamed Ayoub, Fahd M. Alsharif, Eduard Preis, Matthias Wojcik, and Udo Bakowsky. "Surface-Tailored Zein Nanoparticles: Strategies and Applications." Pharmaceutics 13, no. 9 (August 28, 2021): 1354. http://dx.doi.org/10.3390/pharmaceutics13091354.

Full text

Abstract:

Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

APA, Harvard, Vancouver, ISO, and other styles

21

Mahankali, Sumalatha, Jagadish Kalava, Yugandhar Garapati, Bullarao Domathoti, Venkata rao Maddumala, and Venkatesa Prabhu Sundramurty. "A Treatment to Cure Diabetes Using Plant-Based Drug Discovery." Evidence-Based Complementary and Alternative Medicine 2022 (May 9, 2022): 1–12. http://dx.doi.org/10.1155/2022/8621665.

Full text

Abstract:

The field of peptides and proteins has opened up new doors for plant-based medication development because of analytical breakthroughs. Enzymatic breakdown of plant-specific proteins yields bioactive peptides. These plant-based proteins and peptides, in addition to their in vitro and vivo outcomes for diabetes treatment, are discussed in this study. The secondary metabolites of vegetation can interfere with the extraction, separation, characterization, and commercialization of plant proteins through the pharmaceutical industry. Glucose-lowering diabetic peptides are a hot commodity. For a wide range of illnesses, bioactive peptides from flora can offer up new avenues for the development of cost-effective therapy options.

APA, Harvard, Vancouver, ISO, and other styles

22

Lewis, Walter H. "Pharmaceutical Discoveries Based on Ethnomedicinal Plants: 1985 to 2000 and Beyond1." Economic Botany 57, no. 1 (January 2003): 126–34. http://dx.doi.org/10.1663/0013-0001(2003)057[0126:pdboep]2.0.co;2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Kazir, Meital, and Yoav D. Livney. "Plant-Based Seafood Analogs." Molecules 26, no. 6 (March 12, 2021): 1559. http://dx.doi.org/10.3390/molecules26061559.

Full text

Abstract:

There is a growing global need to shift from animal- towards plant-based diets. The main motivations are environmental/sustainability-, human health- and animal welfare concerns. The aim is to replace traditional animal-based food with various alternatives, predominantly plant-based analogs. The elevated consumption of fish and seafood, leads to negative impacts on the ecosystem, due to dwindling biodiversity, environmental damage and fish diseases related to large-scale marine farming, and increased intake of toxic substances, particularly heavy metals, which accumulate in fish due to water pollution. While these facts lead to increased awareness and rising dietary shifts towards vegetarian and vegan lifestyles, still the majority of seafood consumers seek traditional products. This encourages the development of plant-based analogs for fish and seafood, mimicking the texture and sensorial properties of fish-meat, seafood, or processed fish products. Mimicking the internal structure and texture of fish or seafood requires simulating their nanometric fibrous-gel structure. Common techniques of structuring plant-based proteins into such textures include hydrospinning, electrospinning, extrusion, and 3D printing. The conditions required in each technique, the physicochemical and functional properties of the proteins, along with the use of other non-protein functional ingredients are reviewed. Trends and possible future developments are discussed.

APA, Harvard, Vancouver, ISO, and other styles

24

Salehin, Salman, Peter Rasmussen, Steven Mai, Muhammad Mushtaq, Mayank Agarwal, Syed Mustajab Hasan, Shahran Salehin, Muhammad Raja, Syed Gilani, and Wissam I. Khalife. "Plant Based Diet and Its Effect on Cardiovascular Disease." International Journal of Environmental Research and Public Health 20, no. 4 (February 14, 2023): 3337. http://dx.doi.org/10.3390/ijerph20043337.

Full text

Abstract:

Cardiovascular disease remains the leading cause of death globally and here in the United States. Diet has a major impact on the pathogenesis of atherosclerosis and subsequent cardiovascular morbidity and mortality. An unhealthy diet is the most significant potential behavioral and modifiable risk factor for ischemic heart disease. Despite these established facts, dietary interventions are far less frequent than pharmaceutical and procedural interventions in the management of cardiovascular disease. The beneficial effects of a plant-based diet on cardiovascular morbidity and mortality have been demonstrated in a number of recent clinical studies. The significant findings of each study are discussed in this review article, highlighting the role of a healthy plant-based diet in improving cardiovascular outcomes. From a clinician’s standpoint, the knowledge and understanding of the facts and data points from these recent clinical studies would ensure more effective patient counseling on the substantial benefits of dietary interventions.

APA, Harvard, Vancouver, ISO, and other styles

25

Hidalgo, Diego, Raul Sanchez, Liliana Lalaleo, Mercedes Bonfill, Purificacion Corchete, and Javier Palazon. "Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures." Current Medicinal Chemistry 25, no. 30 (September 27, 2018): 3577–96. http://dx.doi.org/10.2174/0929867325666180309124317.

Full text

Abstract:

Background: Plant biofactories are biotechnological platforms based on plant cell and organ cultures used for the production of pharmaceuticals and biopharmaceuticals, although to date only a few of these systems have successfully been implemented at an industrial level. Metabolic engineering is possibly the most straightforward strategy to boost pharmaceutical production in plant biofactories, but social opposition to the use of GMOs means empirical approaches are still being used. Plant secondary metabolism involves thousands of different enzymes, some of which catalyze specific reactions, giving one product from a particular substrate, whereas others can yield multiple products from the same substrate. This trait opens plant cell biofactories to new applications, in which the natural metabolic machinery of plants can be harnessed for the bioconversion of phytochemicals or even the production of new bioactive compounds. Synthetic biological pipelines involving the bioconversion of natural substrates into products with a high market value may be established by the heterologous expression of target metabolic genes in model plants. Objective: To summarize the state of the art of plant biofactories and their applications for the pipeline production of cosme-, pharma- and biopharmaceuticals. Results: In order to demonstrate the great potential of plant biofactories for multiple applications in the biotechnological production of pharmaceuticals and biopharmaceuticals, this review broadly covers the following: plant biofactories based on cell and hairy root cultures; secondary metabolite production; biotransformation reactions; metabolic engineering tools applied in plant biofactories; and biopharmaceutical production.

APA, Harvard, Vancouver, ISO, and other styles

26

Chen, Zhan Li, Xiao Hua Huang, Zhen Zhong Liu, and Xian Rong Sun. "A Novel Application of Combined Bio-Technologies on Chemical Synthesis-Based Pharmaceutical Wastewater." Advanced Materials Research 455-456 (January 2012): 1261–66. http://dx.doi.org/10.4028/www.scientific.net/amr.455-456.1261.

Full text

Abstract:

This chemical synthesis-based pharmaceutical wastewater is treated by the process of hybrid hydrolysis acidification technique (HHAT) with anaerobic-low DO condition and the hybrid aerobic bio-technology consisted of alternate-flow biological reactor (ABR) and two-way-flow biological aerated filter (TBAF). The micro aerobic technology was employed in the HHAT and showed its advantages in refractory organic wastewater treatment. The largest plant in pharmaceutical wastewater treatment at home was built. The practice shows that the organics can be greatly removed and the effluent can reach the First Grade Discharge Standard which can be reclaimed with advanced treatment. The performance indicates that the combined bio-technologies are stable in pharmaceutical wastewater treatment.

APA, Harvard, Vancouver, ISO, and other styles

27

Horn, Michael E., Kameshwari M. Pappu, Michele R. Bailey, Richard C. Clough, Mark Barker, Joseph M. Jilka, John A. Howard, and Stephen J. Streatfield. "Advantageous Features of Plant-based Systems for the Development of HIV Vaccines." Journal of Drug Targeting 11, no. 8-10 (January 2003): 539–45. http://dx.doi.org/10.1080/10611860410001669992.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

dos Santos, Darline B. dos, Janaina A. Lemos, Sued E. M. Miranda, Leonardo D. Di Di Filippo, Jonatas L. Duarte, Lucas A. M. Ferreira, Andre L. B. Barros, and Anna E. M. F. M. Oliveira. "Current Applications of Plant-Based Drug Delivery Nano Systems for Leishmaniasis Treatment." Pharmaceutics 14, no. 11 (October 29, 2022): 2339. http://dx.doi.org/10.3390/pharmaceutics14112339.

Full text

Abstract:

Leishmania is a trypanosomatid that causes leishmaniasis. It is transmitted to vertebrate hosts during the blood meal of phlebotomine sandflies. The clinical manifestations of the disease are associated with several factors, such as the Leishmania species, virulence and pathogenicity, the host–parasite relationship, and the host’s immune system. Although its causative agents have been known and studied for decades, there have been few advances in the chemotherapy of leishmaniasis. The urgency of more selective and less toxic alternatives for the treatment of leishmaniasis leads to research focused on the study of new pharmaceuticals, improvement of existing drugs, and new routes of drug administration. Natural resources of plant origin are promising sources of bioactive substances, and the use of ethnopharmacology and folk medicine leads to interest in studying new medications from phytocomplexes. However, the intrinsic low water solubility of plant derivatives is an obstacle to developing a therapeutic product. Nanotechnology could help overcome these obstacles by improving the availability of common substances in water. To contribute to this scenario, this article provides a review of nanocarriers developed for delivering plant-extracted compounds to treat clinical forms of leishmaniasis and critically analyzing them and pointing out the future perspectives for their application.

APA, Harvard, Vancouver, ISO, and other styles

29

Choudhary, Shailja, Hemlata Kaurav, and Gitika Chaudhary. "ADHATODA VASICA (VASAPATRA): A REVIEW BASED UPON ITS MEDICINAL PROPERTIES." International Journal of Research in Ayurveda and Pharmacy 12, no. 3 (July 6, 2021): 79–87. http://dx.doi.org/10.7897/2277-4343.120379.

Full text

Abstract:

Adhatoda vasica (L.) Nees is also known as Justicia adhatoda L. belongs to the family Acanthaceae and is considered the most significant plant in the world. It is commonly known as Vasaka, Vasica, Adosa, Malbur nut and is distributed in various regions of India and throughout the world. It is a well-known plant in Ayurveda and Unani medicinal system. This plant has been used in the indigenous medicinal system of India for more than 2000 years. The plant has great medicinal importance and is used to treat various diseases and disorders mainly respiratory tract diseases like cough, symptoms of common cold, asthma, tuberculosis and chronic bronchitis. All the parts of the plant are used in medicines. Vasicine is the main chemical constituent present in this plant which possesses various medicinal properties and is used in different Ayurveda formulations. Also, it contains various reported pharmacological properties like antispasmodic, sedative, expectorant, antitussive, oxytocic, antibacterial, anti-diabetic, wound healing, abortifacient, antiasthma and anti-pyorrhea.

APA, Harvard, Vancouver, ISO, and other styles

30

Burcea, Alexandru, Ioana Boeraş, Claudia-Maria Mihuţ, Doru Bănăduc, Claudiu Matei, and Angela Curtean-Bănăduc. "Adding the Mureş River Basin (Transylvania, Romania) to the List of Hotspots with High Contamination with Pharmaceuticals." Sustainability 12, no. 23 (December 7, 2020): 10197. http://dx.doi.org/10.3390/su122310197.

Full text

Abstract:

Background: The Mureș River Basin is a long-term heavily polluted watershed, in a situation of climate changes with decreasing water flow and related decreasing dilution capacity. Here, a mixture of emerging pollutants such as pharmaceuticals were targeted to reveal potential risks regarding the natural lotic ecosystems. Due to the continuous discharge into the environment, pharmaceuticals are gaining persistent organic pollutant characteristics and are considered emerging pollutants. Based on the hazard quotient, this research highlights the dangerous concentrations of carbamazepine, ibuprofen, furosemide, and enalapril in river water. Results: High levels of four pharmaceutical compounds (carbamazepine, ibuprofen, furosemide, and enalapril) and some of their derived metabolites (enalaprilat, carboxyibuprofen, 1-hydroxyibuprofen, and 2-hydroxyibuprofen) were reported in our study in the Mureș River Basin. Overall, pharmaceutical concentrations were found to be highest in the wastewater treatment plant (WWTP) effluent, median downstream of the WWTP, and lowest upstream of the WWTP, as was expected. For all pharmaceutical compounds tested, we recorded concentrations above the limit of quantification (LOQ) in at least one of the sites tested. Carbamazepine exhibited the highest mean values upstream, downstream, and at the WWTP. As expected, the highest concentrations for all the studied pharmaceutical compounds were detected in the WWTP effluent. All Hazard Quotient (HQ) values were below one (on a logarithmic scale in base 10), with the highest values in the WWTP and the lowest in the river upstream of the WWTP. The HQ intervals were in the same range for furosemide, carbamazepine, and ibuprofen at each of the three different sites: upstream WWTP effluent, and downstream. The interval for enalapril stands out as having the lowest HQ at all three sites. Conclusions: Based on these results, the large and complex hydrographical system Mureș River Basin was transformed from a grey area, with little information about pharmaceutical contamination, to a hotspot in terms of contamination with emerging pollutants. Pharmaceutical compound concentrations were found to be the highest in WWTP effluents. The WWTP effluent concentrations were among the highest in Europe, indicating that treatment plants are the primary source of water pollution with pharmaceuticals compounds. The detected levels were higher than the safety limit for carbamazepine and ibuprofen. The determined HQ values imply that the measured levels do pose a threat to the environment for the studied pharmaceuticals. Based on the obtained results, human communities can assess, monitor, predict, and adapt in time to these already-present regional challenges and risks for sustainable use of natural resources, including water and associated products and services.

APA, Harvard, Vancouver, ISO, and other styles

31

Paiva-Santos, Ana Cláudia, Ana Margarida Herdade, Catarina Guerra, Diana Peixoto, Miguel Pereira-Silva, Mahdi Zeinali, Filipa Mascarenhas-Melo, António Paranhos, and Francisco Veiga. "Plant-mediated green synthesis of metal-based nanoparticles for dermopharmaceutical and cosmetic applications." International Journal of Pharmaceutics 597 (March 2021): 120311. http://dx.doi.org/10.1016/j.ijpharm.2021.120311.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

He, Chuqi, Haodong Wang, Yucheng Yang, Yayan Huang, Xueqin Zhang, Moses Arowo, Jing Ye, Na Zhang, and Meitian Xiao. "Drying Behavior and Kinetics of Drying Process of Plant-Based Enteric Hard Capsules." Pharmaceutics 13, no. 3 (March 5, 2021): 335. http://dx.doi.org/10.3390/pharmaceutics13030335.

Full text

Abstract:

The drying process is a significant step in the manufacturing process of enteric hard capsules, which affects the physical and chemical properties of the capsules. Thus, the drying characteristics of plant-based enteric hard capsules were investigated at a constant air velocity of 2 m/s in a bench scale hot-air dryer under a temperature range of 25 to 45 °C and relative humidity of 40 to 80%. Results indicate that the drying process of the capsules mainly occur in a falling-rate period, implying that moisture transfer in the capsules is governed by internal moisture diffusion rate. High temperature and low relative humidity reduce drying time but increase the drying rate of the capsules. Investigation results of the mechanical properties and storage stability of the capsules, however, reveal that a fast drying rate leads to plant-based enteric hard capsules of low quality. Scanning electron microscopy further demonstrates that more layered cracks appear in capsules produced under a faster drying rate. The Page model yielded the best fit for describing thin-layer drying of the capsules based on the coefficient of determination and reduced chi-square. Moreover, it was established that the effective moisture diffusivity of the capsules increases with an increase in drying temperature or reduction in relative humidity.

APA, Harvard, Vancouver, ISO, and other styles

33

Popova, Aneta, Dasha Mihaylova, and Alexander Spasov. "Plant-based Remedies with Reference to Respiratory Diseases – A Review." Open Biotechnology Journal 15, no. 1 (July 7, 2021): 46–58. http://dx.doi.org/10.2174/1874434602015010046.

Full text

Abstract:

In the era of air pollutants, respiratory diseases are a very common diagnosis in children, adolescents, and adults. Disorders of the respiratory system can affect both upper and lower respiratory system, and cause an immense worldwide health, economical and psychological burden. Considerable attention is drawn to the use of plant-based products for the prevention and cure of health challenges, with respect of their eco-friendliness and very few side effects. Exposure to nature and active plant interaction is considered beneficial to physical and mental health. Plant-based drugs primarily target the immune and cardiovascular systems. Biologically active substances with different value can be identified from both terrestrial or marine botanicals, whose therapeutic abilities are an efficient control of an array of diseases. In view of the potential of plant agents to positively influence respiratory diseases, this review will provide the reader with recent objective findings in the field of plant therapy and pharmaceutical agents and their ability to alter the physical and psychological complications of airborne diseases.

APA, Harvard, Vancouver, ISO, and other styles

34

Shang, Qiu Feng, and Lin Zhang. "Automation Control System of Pharmaceutical Factory Based on Wireless Sensor Network." Applied Mechanics and Materials 397-400 (September 2013): 1271–77. http://dx.doi.org/10.4028/www.scientific.net/amm.397-400.1271.

Full text

Abstract:

In view of the traditional wired sensing network PLC control system wiring difficulty, the equipment mobilized shortcoming, this article has designed based on the ZigBee wireless communication pharmaceutical factory automation control system. Using the ZigBee technology realization wireless sensing network, completes automatically to the plant production in various parameters monitor, the analysis, processing, automatically does not conform to the request parameter to completely or the part production process in to carry on the adjustment. This design uses the LabView software to replace the configuration software to complete the backstage the movement. Using LabView to carry on the instrument system the design, the examination and the realization, may reduce the system the development time, enhances the production efficiency. This system has the broad application prospect.

APA, Harvard, Vancouver, ISO, and other styles

35

Cefali, L. C., J. A. Ataide, P. Moriel, M. A. Foglio, and P. G. Mazzola. "Plant-based active photoprotectants for sunscreens." International Journal of Cosmetic Science 38, no. 4 (March 26, 2016): 346–53. http://dx.doi.org/10.1111/ics.12316.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Shukla, Pushp Sheel, Tudor Borza, Alan T. Critchley, and Balakrishnan Prithiviraj. "Seaweed-Based Compounds and Products for Sustainable Protection against Plant Pathogens." Marine Drugs 19, no. 2 (January 25, 2021): 59. http://dx.doi.org/10.3390/md19020059.

Full text

Abstract:

Sustainable agricultural practices increasingly demand novel, environmentally friendly compounds which induce plant immunity against pathogens. Stimulating plant immunity using seaweed extracts is a highly viable strategy, as these formulations contain many bio-elicitors (phyco-elicitors) which can significantly boost natural plant immunity. Certain bioactive elicitors present in a multitude of extracts of seaweeds (both commercially available and bench-scale laboratory formulations) activate pathogen-associated molecular patterns (PAMPs) due to their structural similarity (i.e., analogous structure) with pathogen-derived molecules. This is achieved via the priming and/or elicitation of the defense responses of the induced systemic resistance (ISR) and systemic acquired resistance (SAR) pathways. Knowledge accumulated over the past few decades is reviewed here, aiming to explain why certain seaweed-derived bioactives have such tremendous potential to elicit plant defense responses with considerable economic significance, particularly with increasing biotic stress impacts due to climate change and the concomitant move to sustainable agriculture and away from synthetic chemistry and environmental damage. Various extracts of seaweeds display remarkably different modes of action(s) which can manipulate the plant defense responses when applied. This review focuses on both the similarities and differences amongst the modes of actions of several different seaweed extracts, as well as their individual components. Novel biotechnological approaches for the development of new commercial products for crop protection, in a sustainable manner, are also suggested.

APA, Harvard, Vancouver, ISO, and other styles

37

Liu, Xinxin, Qixuan Lin, Yuhuan Yan, Feng Peng, Runcang Sun, and Junli Ren. "Hemicellulose from Plant Biomass in Medical and Pharmaceutical Application: A Critical Review." Current Medicinal Chemistry 26, no. 14 (July 24, 2019): 2430–55. http://dx.doi.org/10.2174/0929867324666170705113657.

Full text

Abstract:

Background:Due to the non-toxicity, abundance and biodegradability, recently more and more attention has been focused on the exploration of hemicellulose as the potential substrate for the production of liquid fuels and other value-added chemicals and materials in different fields. This review aims to summarize the current knowledge on the promising application of nature hemicellulose and its derivative products including its degradation products, its new derivatives and hemicellulosebased medical biodegradable materials in the medical and pharmaceutical field, especially for inmmune regulation, bacteria inhibition, drug release, anti-caries, scaffold materials and anti-tumor.Methods:We searched the related papers about the medical and pharmaceutical application of hemicellulose and its derivative products, and summarized their preparation methods, properties and use effects.Results:Two hundred and twenty-seven papers were included in this review. Forty-seven papers introduced the extraction and application in immune regulation of nature hemicellulose, such as xylan, mannan, xyloglucan (XG) and β-glucan. Seventy-seven papers mentioned the preparation and application of degradation products of hemicellulose for adjusting intestinal function, maintaining blood glucose levels, enhancing the immunity and alleviating human fatigue fields such as xylooligosaccharides, xylitol, xylose, arabinose, etc. The preparation of hemicellulose derivatives were described in thirty-two papers such as hemicellulose esters, hemicellulose ethers and their effects on anticoagulants, adsorption of creatinine, the addition of immune cells and the inhibition of harmful bacteria. Finally, the preparations of hemicellulose-based materials such as hydrogels and membrane for the field of drug release, cell immobilization, cancer therapy and wound dressings were presented using fifty-five papers.Conclusion:The structure of hemicellulose-based products has the significant impact on properties and the use effect for the immunity, and treating various diseases of human. However, some efforts should be made to explore and improve the properties of hemicellulose-based products and design the new materials to broaden hemicellulose applications.

APA, Harvard, Vancouver, ISO, and other styles

38

Hassan, A. B. M. Khalid, and Kazi Firoz Ahmed. "Design and analysis of an off-grid PV plant for higher utilization efficiency in the field of pharmaceutical industry considering global pandemic state ." AIUB Journal of Science and Engineering (AJSE) 20, no. 1 (April 15, 2021): 47–58. http://dx.doi.org/10.53799/ajse.v20i1.144.

Full text

Abstract:

According to the concern of WHO the less association of people in an office may restrict the likelihood of spreading this COVID-19 infection. And it applies to all kinds of organizations. On the other hand, the pharmaceutical companies are working hard to maintain uninterrupted production of vaccine and medicines. This paper focuses on the main layer which is the power system management and its utilization through the less involvement of any individual. Automation and controlling the system remotely can be a good solution. In the design process the FDA proposed structure for the Pharmaceuticals needs to be maintained as well. One of the significant necessities is most of the energy should come from environment friendly system and in Bangladesh sunlight-based energy is the best solution right now. Solar energy utilization efficiency can be increased using the data logging system and machine learning algorithms from that archived data. In this paper, a SCADA operated Off-Grid Solar PV Automation System has been proposed to increase the utilization efficiency. To predict solar power availability over time and perform efficient energy trafficking, the automation system will analyze previous data and perform situational awareness operations for uninterrupted solar power generation. The proposed automation system has been designed focusing on pharmaceutical manufacturing utilities. A comprehensive analysis of the proposed automation system for pharmaceuticals industry applications has also been presented in this paper. The continuous monitoring system for this Off-Grid Solar PV power generating unit preserves multiple data entries, which increases with time and subjected to energy trafficking. And this energy trafficking based on machine learning increases the overall solar energy utilization efficiency.

APA, Harvard, Vancouver, ISO, and other styles

39

Bryatov, S. R., and A. A. Borodinov. "Blockchain technology in the pharmaceutical supply chain: researching a business model based on Hyperledger Fabric." Information Technology and Nanotechnology, no. 2416 (2019): 134–40. http://dx.doi.org/10.18287/1613-0073-2019-2416-134-140.

Full text

Abstract:

Pharmaceutical companies that manufacture, ship and supply products face difficulties in tracking their products, allowing counterfeiters to inject counterfeit drugs into the system. This situation is observed, in particular, in the Russian market of turnover of pharmaceutical products, although the problem has long been global. The ability of blockchain systems to pinpoint the origin of data makes them particularly suitable for pharmaceutical supply chain applications. The data stored in the blockchain distributed register on the identification of drugs produced by the plant, as well as records of their movements throughout the supply chain, can accurately determine the authenticity of pharmaceutical products lying on the shelves of pharmacies. The development and implementation of such a system can be a big step towards winning the exhausting fight against the easy availability of counterfeit drugs and medical products. In the first part of this work, the main characteristics and features of the functioning of blockchain systems will be studied. In the second and final part, the designed concept of the pharmaceutical turnover control system based on the blockchain technology Hyperledger Fabric using the Hyperledger Composer development environment will be investigated.

APA, Harvard, Vancouver, ISO, and other styles

40

Narayana, D. B. Anantha. "PHYTO-PHARMACEUTICAL DEFINITION UNDER DRUG REGULATIONS, INDIA NEEDS AN URGENT REVIEW." INDIAN DRUGS 57, no. 12 (April 20, 2021): 5–6. http://dx.doi.org/10.53879/id.57.12.p0005.

Full text

Abstract:

Dear Reader, An Amendment to the Drugs and Cosmetics Regulations to permit scientifically developed plant based leads as drugs named “phytopharmaceuticals”, was notified for the first time in November 2015. This regulation has now been further amended and revised to put it under new drug definitions and provided more provisions for greater clarity in 2019. However, having championed these regulations (as part of the Indian Pharmacopoeia Commission’s Expert Committee on Herbals) for nearly a decade a greater number of drugs should have come out through this route given the scientific capability of the Indian drug sector and academia. However, the only information in the public domain as on date is the approval for conducting human clinical trials of a plant based lead for testing the protective or curative potency of Coculous hirsutus against SARS – CoV-2 given by the Drugs Controller General of India. A purified fraction of the stem of this plant commonly called broom creeper has been tested for sinnococculine markers as the lead drug candidate.

APA, Harvard, Vancouver, ISO, and other styles

41

Vrublevska, Kr, I. Petjkane, L. Krigere, Kr Saleniece, and R. Muceniece. "Experience of the dispensing of plant and sea animal extract-based rheumatoid arthritis drugs." European Journal of Pharmaceutical Sciences 32, no. 1 (September 2007): S33. http://dx.doi.org/10.1016/j.ejps.2007.05.070.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Bolaños-Martínez, Omayra C., Ganesan Mahendran, Sergio Rosales-Mendoza, and Sornkanok Vimolmangkang. "Current Status and Perspective on the Use of Viral-Based Vectors in Eukaryotic Microalgae." Marine Drugs 20, no. 7 (June 29, 2022): 434. http://dx.doi.org/10.3390/md20070434.

Full text

Abstract:

During the last two decades, microalgae have attracted increasing interest, both commercially and scientifically. Commercial potential involves utilizing valuable natural compounds, including carotenoids, polysaccharides, and polyunsaturated fatty acids, which are widely applicable in food, biofuel, and pharmaceutical industries. Conversely, scientific potential focuses on bioreactors for producing recombinant proteins and developing viable technologies to significantly increase the yield and harvest periods. Here, viral-based vectors and transient expression strategies have significantly contributed to improving plant biotechnology. We present an updated outlook covering microalgal biotechnology for pharmaceutical application, transformation techniques for generating recombinant proteins, and genetic engineering tactics for viral-based vector construction. Challenges in industrial application are also discussed.

APA, Harvard, Vancouver, ISO, and other styles

43

Dewanjee, Saikat, Pratik Chakraborty, Biswajit Mukherjee, and Vincenzo De Feo. "Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy." International Journal of Molecular Sciences 21, no. 6 (March 23, 2020): 2217. http://dx.doi.org/10.3390/ijms21062217.

Full text

Abstract:

Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

APA, Harvard, Vancouver, ISO, and other styles

44

Cunningham, Christopher W. "Plant-Based Modulators of Endocannabinoid Signaling." Journal of Natural Products 82, no. 3 (February 28, 2019): 636–46. http://dx.doi.org/10.1021/acs.jnatprod.8b00874.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Kopertekh, Lilya, and Joachim Schiemann. "Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives." Current Medicinal Chemistry 26, no. 3 (March 26, 2019): 365–80. http://dx.doi.org/10.2174/0929867324666170718114724.

Full text

Abstract:

During the last two decades, the production of pharmaceutical proteins in plants evolved from proof of concept to established technology adopted by several biotechnological companies. This progress is particularly based on intensive research starting stable genetic transformation and moving to transient expression. Due to its advantages in yield and speed of protein production transient expression platforms became the leading plant-based manufacturing technology. Current transient expression methods rely on Agrobacteriummediated delivery of expression vectors into plant cells. In recent years, great advances have been made in the improvement of expression vectors, host cell engineering as well as in the development of commercial manufacturing processes. Several GMP-certified large-scale production facilities exist around the world to utilize agroinfiltration method. A number of pharmaceutical proteins produced by transient expression are currently in clinical development. The great potential of transient expression platform in respect to rapid response to emerging pandemics was demonstrated by the production of experimental ZMapp antibodies against Ebola virus as well as influenza vaccines. This review is focused on current design, status and future perspectives of plant transient expression system for the production of biopharmaceutical proteins.

APA, Harvard, Vancouver, ISO, and other styles

46

Narkevich, Igor A., Stanislav V. Stepanov, Alla O. Volgusheva, Yuri Zvyagin Y. Zvyagin, Svetlana Vorobeva, Vladimir Perelygin, and Daria Dobrova. "Alexander Stepanovich Ardemasov: Party director of the Leningrad Pharmaceutical Institute in 1940-1942." Pharmacy Formulas 2, no. 3 (October 9, 2020): 116–21. http://dx.doi.org/10.17816/phf45993.

Full text

Abstract:

Based on unpublished archival documents from the Central State Archive of Party Historical Documents, the article reconstructs the biography of A.S. Ardemasov, a party worker, the Director of the Leningrad Pharmaceutical Institute (now Saint Petersburg State Chemical and Pharmaceutical University) in the pre-war period, during the Great Patriotic War (WWII) and the post-war years. During his path of life, A.S. Ardemasov headed the leading chemical enterprises of the USSR: the Leningrad Laminated Plastics Plant (now the Laminated Plastics Plant, LLC, St. Petersburg), the State Institute of Applied Chemistry (now the Russian Scientific Center of Applied Chemistry).

APA, Harvard, Vancouver, ISO, and other styles

47

Abeyrathne, Edirisinghe Dewage Nalaka Sandun, Kichang Nam, Xi Huang, and Dong Uk Ahn. "Plant- and Animal-Based Antioxidants’ Structure, Efficacy, Mechanisms, and Applications: A Review." Antioxidants 11, no. 5 (May 23, 2022): 1025. http://dx.doi.org/10.3390/antiox11051025.

Full text

Abstract:

Antioxidants are compounds that normally prevent lipid and protein oxidation. They play a major role in preventing many adverse conditions in the human body, including inflammation and cancer. Synthetic antioxidants are widely used in the food industry to prevent the production of adverse compounds that harm humans. However, plant- and animal-based antioxidants are more appealing to consumers than synthetic antioxidants. Plant-based antioxidants are mainly phenolic compounds, carotenoids, and vitamins, while animal-based antioxidants are mainly whole protein or the peptides of meat, fish, egg, milk, and plant proteins. Plant-based antioxidants mainly consist of aromatic rings, while animal-based antioxidants mainly consist of amino acids. The phenolic compounds and peptides act differently in preventing oxidation and can be used in the food and pharmaceutical industries. Therefore, compared with animal-based antioxidants, plant-based compounds are more practical in the food industry. Even though plant-based antioxidant compounds are good sources of antioxidants, animal-based peptides (individual peptides) cannot be considered antioxidant compounds to add to food. However, they can be considered an ingredient that will enhance the antioxidant capacity. This review mainly compares plant- and animal-based antioxidants’ structure, efficacy, mechanisms, and applications.

APA, Harvard, Vancouver, ISO, and other styles

48

Prashar, Anupama. "Adopting Six Sigma DMAIC for environmental considerations in process industry environment." TQM Journal 32, no. 6 (May 5, 2020): 1241–61. http://dx.doi.org/10.1108/tqm-09-2019-0226.

Full text

Abstract:

PurposeThe aim of the study is to develop and apply a continuous improvement (CI) framework by introducing environmental considerations into the Six Sigma DMAIC (define–measure–analyze–improve–control) cycle for a continuous identification, evaluation and implementation of promising opportunities of enhancing environmental sustainability of process-based industries.Design/methodology/approachAction research approach within the research design of a single case study was used for illustrating the application of the proposed DMAIC framework for improving operational and environmental performance in the process-industry environment of a pharmaceutical manufacturing company.FindingsThe case study illustrated the implementation of DMAIC cycle for optimizing the energy consumption of pharmaceutical plants producing bulk drugs for medication. After improving the energy distribution in the cooling tower (CTW), chilled brine (CHB) and chilled water (CHW) system, the pharmaceutical plant was able to achieve an annual economic benefit of US$97,047 and environmental benefits of mitigating CO2 emissions of 807.44 t (CO2) by reducing the electricity and furnace oil consumption.Originality/valueThe framework may be adopted for environmental considerations specific to process-based industry such as chemical plant, fertilizer units, thermal power plant and food processing industry.

APA, Harvard, Vancouver, ISO, and other styles

49

Hamdy, Nadia M., Amira A. Boseila, Ahmed Ramadan, and Emad B. Basalious. "Iron Oxide Nanoparticles-Plant Insignia Synthesis with Favorable Biomedical Activities and Less Toxicity, in the “Era of the-Green”: A Systematic Review." Pharmaceutics 14, no. 4 (April 12, 2022): 844. http://dx.doi.org/10.3390/pharmaceutics14040844.

Full text

Abstract:

In the era of favoring environment-friendly approaches for pharmaceutical synthesis, “green synthesis” is expanding. Green-based nanomedicine (NM), being less toxic and if having biomedical acceptable activities, thence, the chemical methods of synthesis are to be replaced by plants for reductive synthesis. Iron oxide nanoparticles (IONPs) exhibited remarkable anti-microbial and anti-cancer properties, besides being a drug delivery tool. However, owing to limitations related to the chemical synthetic method, plant-mediated green synthesis has been recognized as a promising alternative synthetic method. This systematic review (SR) is addressing plant-based IONPs green synthesis, characteristics, and toxicity studies as well as their potential biomedical applications. Furthermore, the plant-based green-synthesized IONPs in comparison to nanoparticles (NPs) synthesized via other conventional methods, characteristics, and efficacy or toxicity profiles would be mentioned (if available). Search strategy design utilized electronic databases including Science Direct, PubMed, and Google Scholar search. Selection criteria included recent clinical studies, available in the English language, published till PROSPERO registration. After screening articles obtained by first electronic database search, by title, abstract and applying the PICO criteria, the search results yielded a total of 453 articles. After further full text filtrations only 48 articles were included. In conclusion, the current SR emphasizes the perspective of the IONPs plant-mediated green synthesis advantage(s) when utilized in the biomedical pharmaceutical field, with less toxicity.

APA, Harvard, Vancouver, ISO, and other styles

50

Harun, Nur Fadilah, and Farah Hanim Ab Hamid. "An overview of the extraction methods of plant-based natural antioxidant compounds." Malaysian Journal of Chemical Engineering and Technology (MJCET) 4, no. 2 (October 31, 2021): 73. http://dx.doi.org/10.24191/mjcet.v4i2.13055.

Full text

Abstract:

Natural antioxidants are widely used in food additives, application in functional foods or also known as ingredients that offer health benefits that extend beyond their nutritional value, and pharmaceutical. These natural antioxidants such as carotenoids, vitamins, and polyphenol can be obtained from fruit, vegetables, and traditional herbal medicines. However, there have several issues regarding the conventional extraction method to extract natural antioxidants compounds from food and medicinal plants such as require a large volume of solvent and long extraction time. Therefore, new green extraction methods such as microwave-assisted, ultrasound-assisted, pulsed electric field, enzyme-assisted, supercritical fluid, and pressurised liquid, technologies were studied to overcome these constraints. Thus, different types of extraction and their mechanism in natural antioxidant compounds extraction was further discussed in this study. Besides, the main classes, source of natural antioxidants and their health benefits also were presented in this paper.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Plant Based Pharmaceutical'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles