Academic literature on the topic 'Plant Based Pharmaceutical'
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Journal articles on the topic "Plant Based Pharmaceutical"
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Pal, Rashmi Saxena, Yogendra Pal, Ankita Wal, and Pranay Wal. "Current Review on Plant based Pharmaceutical Excipients." Open Medicine Journal 6, no. 1 (February 19, 2019): 1–5. http://dx.doi.org/10.2174/1874220301906010001.
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Background: Plants act as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this, they act as excellent pharmaceutical aids as well as excipients. Objective: An effort has been made for the complete study of plants under different categories of plant-based thickeners, emulsifiers, suspenders, binders, etc. Materials and Methods: The herbs were differentiated on the basis of their role as flavoring, sweetening, colouring, gelling, thickening, emulsifying, suspending and binding agents. Results: The use of natural excipients to impart the goodness of natural bioactive agents has been hampered by synthetic materials. However, advantages offered by these natural excipients are enormous as being non-toxic, affordable and easily available. The activity of the excipients partly determines the quality of medicines. Conclusion: The herbal excipients act better in many ways when compared to their synthetic substitutes.
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Norikane, Joey H. "The Potential of LEDs in Plant-based Bio-pharmaceutical Production." HortScience 50, no. 9 (September 2015): 1289–92. http://dx.doi.org/10.21273/hortsci.50.9.1289.
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Fraunhofer USA, Inc. Center for Molecular Biotechnology (FhCMB) has pioneered a transient plant-based biopharmaceutical platform to produce vaccines and therapeutics quickly and cost-effectively. Using this platform, plants are grown hydroponically in a controlled environment. The plants are vacuum infiltrated with a recombinant Agrobacteria carrying a plant viral–based hybrid vector and returned to a controlled environment for the target protein to be produced in infiltrated plant tissue. When target protein levels peak in leaf tissue, the plants are harvested and homogenized, extract is clarified and the target protein is purified. There are multiple opportunities in this system for light-emitting diodes (LEDs) to be applied to optimize biomass accumulation and the production of target proteins. There is potential to develop specific photo-recipes to optimize plant growth and target protein production.
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Arora, Saroj, Davinder Singh, Ankita Rajput, Astha Bhatia, Avinash Kumar, Harneetpal Kaur, Palvi Sharma, et al. "Plant-Based Polysaccharides and their Health Functions." Functional Foods in Health and Disease 11, no. 4 (April 14, 2021): 179. http://dx.doi.org/10.31989/ffhd.v11i4.773.
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Plants are valuable source of polysaccharides that make a large portion of our daily diet. These are natural polymers that are essential to sustain life. They provide high-value nutrition and positively help the immune system and improve the digestive properties. They also help in the elimination of toxic by-products from the human body. Polysaccharides and human health are inextricably linked and intertwined. These are also important components of the cell wall that provides its strength and integrity. Due to their indispensable role in human health, it is very important to know the different modifications and loss of nutritional value during the processing of plant material. Nowadays, these plant-based polysaccharides are used for diverse applications including wound dressing, drug delivery, laxative, cosmetic and pharmaceutical preparations. As an emerging area of plant-based medicines to reduce the side effects of synthetic sources, these polysaccharides are used to enhance the immunogenic response against a specific antigen. This review envisages some important polysaccharides (e.g. mucilages and gums, glycosamine glycans and chitin/chitosan) and their medical, cosmetic, and pharmaceutical applications, with emphasis on the relationship between their structure and function.Keywords: Polysaccharides; Nutrition; Health Functions; Cosmetics; Vaccine; Nutraceuticals
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Lakerveld, Richard, Brahim Benyahia, Richard D. Braatz, and Paul I. Barton. "Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant." AIChE Journal 59, no. 10 (April 25, 2013): 3671–85. http://dx.doi.org/10.1002/aic.14107.
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Jensen, Michael K. "New scalable strategy for challenging plant-based medicines." EU Research 32, Autumn 2022 (2022): 17–19. http://dx.doi.org/10.56181/uysc2182.
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A European consortium working on the MIAMi project is using yeast to support sustainable, scalable production of complex chemical compounds in rare plants, to harness their valuable healthcare and pharmaceutical properties. We speak to Dr. Michael Krogh Jensen, Group Leader & Senior Researcher from the Technical University of Denmark.
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Kaloudas, Dimitrios, and Robert Penchovsky. "Plant-Derived Compounds and Their Potential Role in Drug Development." International Journal of Biomedical and Clinical Engineering 7, no. 1 (January 2018): 53–66. http://dx.doi.org/10.4018/ijbce.2018010104.
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This article describes how with the development of biotechnology, plants have gained again a prominent place as a relatively inexpensive source for the creation of recombinant pharmaceuticals. Plant-derived compounds have started playing a major role in the pharmaceutical industry with many plant-based products to have found their way in drugs and chemicals used for the treatment of different diseases and their symptoms. Plant-derived compounds have been tested for the treatment of several types of cancer, Central Nervous System disorders, as enhancers during chemotherapy and as vessels for targeted drug delivery. Genetically modified plant cells have been recruited for the production of therapeutic agencies as well as in the creation of expression systems for virus-like particles that could be used as vaccines. Moreover, microRNAs mimicking the plant ones have the ability to inhibit tumors in mammalian cells. This review describes plant-derived compounds and their properties as potential therapeutic agents and precursors for the development of novel drugs in the pharmaceutical industry.
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LeBlanc, Zacharie, Peter Waterhouse, and Julia Bally. "Plant-Based Vaccines: The Way Ahead?" Viruses 13, no. 1 (December 22, 2020): 5. http://dx.doi.org/10.3390/v13010005.
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Severe virus outbreaks are occurring more often and spreading faster and further than ever. Preparedness plans based on lessons learned from past epidemics can guide behavioral and pharmacological interventions to contain and treat emergent diseases. Although conventional biologics production systems can meet the pharmaceutical needs of a community at homeostasis, the COVID-19 pandemic has created an abrupt rise in demand for vaccines and therapeutics that highlight the gaps in this supply chain’s ability to quickly develop and produce biologics in emergency situations given a short lead time. Considering the projected requirements for COVID-19 vaccines and the necessity for expedited large scale manufacture the capabilities of current biologics production systems should be surveyed to determine their applicability to pandemic preparedness. Plant-based biologics production systems have progressed to a state of commercial viability in the past 30 years with the capacity for production of complex, glycosylated, “mammalian compatible” molecules in a system with comparatively low production costs, high scalability, and production flexibility. Continued research drives the expansion of plant virus-based tools for harnessing the full production capacity from the plant biomass in transient systems. Here, we present an overview of vaccine production systems with a focus on plant-based production systems and their potential role as “first responders” in emergency pandemic situations.
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Adekanmi, D. G., and A. E. Olowofoyeku. "African Star Apple: Potentials and Application of Some Indigenous Species in Nigeria." Journal of Applied Sciences and Environmental Management 24, no. 8 (September 9, 2020): 1307–14. http://dx.doi.org/10.4314/jasem.v24i8.1.
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Many research in food and pharmaceuticals are focused on the use of materials as close to nature as possible to limit exposure to harmful synthetic substances. Alternatives are being sought for popular plant based materials leading to increased attention to underutilized plants and creating ripple effects in agriculture, agribusiness, health and pharmaceuticals. A plant that is attaining prominence in Nigeria and in the rain forests of West Africa is the African Star Apple. The plant is best known for the juicy pulp of its fruit but the traditional therapeutic use of parts of the plants are also common. Some authors have investigated and documented some benefits obtained from its leaves, stem, root and fruits. This paper focuses on the features, food and pharmaceutical potentials of the oil, flour, extracts and gum form the African Star Apple. Its fruit is rich in minerals and antioxidant while extracts from various parts of the plant have good antimicrobial and antifungal properties. The review also reveals that the AfricanStar Apple has many potential food and pharmaceutical applications that are yet to be explored.
Keywords: African Star Apple, Chrysophyllum albidum, Phytochemicals, Gum, Extracts.
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Chaiyana, Wantida, Kiattisak Saeio, Wim E. Hennink, and Siriporn Okonogi. "Characterization of potent anticholinesterase plant oil based microemulsion." International Journal of Pharmaceutics 401, no. 1-2 (November 2010): 32–40. http://dx.doi.org/10.1016/j.ijpharm.2010.09.005.
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Shahriari, Amir Ghaffar, and Maziar Habibi-Pirkoohi. "Plant-Based Recombinant Vaccine: Fact or Fiction?" Galen Medical Journal 6, no. 4 (December 29, 2017): 268–80. http://dx.doi.org/10.31661/gmj.v6i4.792.
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In the era of recombinant DNA technology, production of recombinant vaccines in green plants has emerged as an effective approach addressing the problems of traditional vaccine production. Various antigens expressed in different plant species have been so far tested for the production of efficient oral vaccines against human and livestock diseases. However, recombinant vaccines have not yet found a prominent place in pharmaceutical market. There are still many challenges to be addressed to pave the road for commercial production of plant-based recombinant vaccines. Regarding increasing growth in laboratory studies and field trials for development of plant-based vaccines, this review paper provides a comprehensive overview on the topic of plant-derived vaccines and related issues. [GMJ.2017;6(4):268-80] DOI:10.22086/gmj.v6i3.792
Dissertations / Theses on the topic "Plant Based Pharmaceutical"
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Engberg, Erica, and Emilia Johansson. "Ozonation of pharmaceutical residues in a wastewater treatment plant : Modeling the ozone demand based on a multivariate analysis of influential parameters." Thesis, Linköpings universitet, Teknisk biologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151565.
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Most pharmaceutical residues in wastewater treatment plants (WWTPs) end up in the hydrosphere where they cause negative effects on the aquatic life and might disrupt ecosystems. By implementing an ozonation step (treatment with ozone) in the wastewater treatment process, these pharmaceutical residues can be reduced. The purpose of this project was to verify that the ozonation process works in full-scale, thereby verifying a pilot study conducted in 2014 at Tekniska Verken i Linköping AB (TVAB). Additionally, the purpose was to investigate which parameters influence the ozone demand in order to formulate a model for the ozone demand. The initial phases during this thesis were a pre-study and a literature study. This was followed by the multivariate analysis and model construction based on different data from the pilot study. Measurements were performed on the wastewater in the full-scale facility in order to verify the results from the pilot study. Moreover, measurements were performed to find new ozone consuming parameters. The reduction of pharmaceutical residues was similar to the pilot study, although slightly lower. Several parameters and factors that were different between pilot study and new measurements affected the reduction of pharmaceutical residues. For example, DOC and nitrate concentrations have increased since the pilot study in 2014. Also, factors such as the growth in population in Linköping and the differences in design between the pilot plant and the full-scale facility have influenced the reduction of pharmaceutical residues. A control strategy based on a linear relationship between ozone sensitive Ultra Violet Absorption (UVA) left and remaining pharmaceutical residues after ozonation could potentially be used. Moreover, three models were constructed and the Multivariate Analysis 1 (MVA1)-model was deemed as the best, this model includes ozone residual, nitrite, turbidity, simulated Chemical Oxygen Demand (COD(sim)) and ozone dose. The variations in the dose compared to the input parameters for the validation data show that the model predict the ozone dose well. However, in future other interesting parameters can be included in the model to further improve the accuracy in the ozone dose predicted by the model.Många läkemedelsrester i avloppsreningsverken hamnar i hydrosfären där de kan orsaka negativa effekter på det akvatiska livet och högre ekosystem. Genom att införa ett ozoneringssteg (behandling av ozon) på avloppsreningsverken, kan läkemedelsresterna reduceras. Syftet med det här examensarbetet var att verifiera att ozoneringsprocessen fungerade i fullskala och därmed verifiera en pilotstudie som utfördes år 2014 på Tekniska Verken i Linköping AB (TVAB). Syftet var också att undersöka vilka parametrar som påverkade ozonbehovet för att kunna konstruera en modell för ozonbehovet. De initiala faserna under examensarbetet var en förstudie och en litteraturstudie. Dessa följdes av en multivariat analys och modellkonstruktioner baserat på olika data ifrån pilotstudien. Mätningar på fullskaleanläggningen gjordes också för att hitta nya ozonkonsumerande parametrar. Reduktionen av läkemedelsrester liknande reduktionen under pilotstudien, men var dock något lägre. Flera parametrar och faktorer var värden skiljde sig mellan pilotstudien och fullskala påverkade reduktionen av läkemedelsrester. Till exempel, har DOC och nitratkoncentrationen ökat sedan pilotstudien år 2014. Faktorer så som befolkningsökningen i Linköping och de skillnader som fanns i designen hos de två anläggningarna kan också ha påverkat reduktionen av läkemedelsrester. En kontrollstrategi baserat på ett linjärt samband mellan ozonkänslig ultraviolett absorption (UVA) kvar och kvarvarande läkemedelsrester efter ozonering kan eventuellt användas. Tre modeller konstruerades där Multivariat analys 1 (MVA1)-modellen ansågs vara den bästa. Den här modellen inkluderade ozonresidual, nitrit, turbiditet, simulerad chemical oxygen demand (COD(sim)) och ozondos. Variationerna i dosen jämfört med inputparametrarna för validerade data visade att modellen predikterade ozondosen bra. I framtiden kan andra intressanta parameter inkluderas i modellen för att vidare förbättra trovärdigheten i ozondosen som predikteras av modellen.
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Ceresoli, V. "PRODUCTION OF HUMAN RECOMBINANT DIFFERENTIATION FACTORS IN TRANSGENIC TOBACCO PLANTS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/263847.
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Research on bone regeneration began decades ago as a result of intensive studies on bone growth and healing. Bone has been recognised, among the many tissues in human body, as having the highest potential for regeneration, and it is the second most transplanted tissue following blood.
Due to both internal mediators and external mechanical demands, it possesses the intrinsic ability for regeneration and is constantly engaged in a cycle of resorption and renewal undergoing continual chemical exchange and structural remodelling throughout adult life as well as during repair process in response to injury. Despite these abilities, beyond a critical point clinical intervention measures are needed; there are different clinical conditions requiring a large quantity of bone regeneration, such as for skeletal reconstruction of large bone defects created by trauma, infection, or cases in which the regenerative process is compromised, including necrosis, atrophic non-unions and osteoporosis.
To describe the extent of this situation, it is estimated that annually more than 2.2 million patients receive bone defect repairs worldwide, with a cost greater than $2.5 billion just in the United States; this figure is expected to globally double by 2020 due to a variety of factors, including increased life expectancy. The board of the Bone and Joint Decade in 2009 has assessed that half of the people aged over 65, affected by chronic conditions, suffers of joint diseases and that the number of osteoporotic fractures has doubled in the previous 15 years. It should be also pointed out that the worldwide incidence of bone disorders and conditions is increasing in those societies where population ageing is combined with increased obesity and poor physical activity.
Shortcomings, limitations, and complications of current clinical treatments for bone repair and regeneration have been reported in different studies. A variety of graft materials are currently used to enhance bone healing, and the relative success of these materials depends on many factors, not only on the specific properties of the graft itself. In addition to its physical properties, to be effective, a grafting material is required to even provide osteoconductive and/or osteoinductive activities. Osteoconduction, the ability of promoting bone growth by allowing bone formation on material’s surface, may suffice in clinical condition of less severe defects, where sufficient quantities and margins of bone exist. Osteoinduction instead, is the capability of promoting de novo bone formation at soft or hard tissue sites, and offers needful advantages for biologic reconstruction of severe situations.
Among most commonly used materials there are allografts, cadaveric bone usually obtained from a bone bank, autologous grafts, bone harvested from the patient’s own body, or synthetic ones, often made of hydroxyapatite or other naturally and biocompatible substances.
Allografts, mineralized or demineralized, are histocompatible, available in various forms including demineralized bone matrix and cortical grafts and whole-bone segments, depending on the host-site requirements, and provide an osteoconductive environment; however, their osteoinductive capacity is highly variable depending on the processing method and sourcing, and may be present in inadequate amounts for any bone-inductive effect.
To date, autografts serve as the gold standard for bone grafts because they are histocompatible, non-immunogenic, and they offer all of the properties required. Specifically, this material provides an osteoconductive environment (i.e., three-dimensional scaffolds and porous matrix) coupled with cells (i.e., osteoprogenitor cells) as well as growth and differentiation factors(i.e., growth factors) that can result in osteoinduction Nevertheless, autogenous grafting is sometimes an expensive procedure that has a number of shortcomings, including the need for secondary surgery to harvest the graft, donor site morbidity, irregular resorption of transplanted tissue, and limited availability of donor bone. Furthermore autograft may be a useless or inadequate treatment option in cases where the defect site requires larger amounts of bone than is available.
Other commonly used bone repair techniques involve synthetic materials and fillers, and growth and differentiation factors, but, although all these clinical interventions have been shown to improve bone repair, none of them possess all of the necessary characteristics: high osteoinductive and angiogenic potentials, biological safety, low patient morbidity, ready access to surgeons, no size restrictions, long shelf life and reasonable cost; all these limitations have led to an extensive research for alternatives.
The discovery and subsequent production of the osteoinductive agents in bone, the Bone Morphogenetic Proteins (BMPs), have provided the possibility of reducing or avoiding the need for autograft, through a tissue-engineering product.
Clinically, BMPs have demonstrated the potential to replace the use of autogenous bone in many applications so that costs and complications related to harvesting autograft can be prevented; in addition, the ability to control quality, activity and dose of the osteoinductive agent may provide greater assurance of bone induction and repair. Despite this, a widespread therapeutic use of BMPs has been hindered by difficulties in obtaining large amounts of pure, biologically active protein at a cost-effective price.
Thus, the aim of this study was to develop a plant based system for cost-effective production of active recombinant BMPs. This introduction provides a review of the relevant literature pertaining to BMPs (especially to BMP-2) synthesis, processing and recombinant production process.
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Shama, Leslie Marie. "Risk Assessment of Plant-Based Pharmaceuticals and Biologics." Thesis, Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/shama/ShamaL1206.pdf.
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Biotechnology is evolving to produce pharmaceutical proteins in plants. Plantbased pharmaceutical production creates concerns of exposure in an open environment and contamination of the food supply. Consequently, quantitative human health and ecological risk assessments were conducted for aprotinin, gastric lipase, and LT-B expressed in maize. A comparative, qualitative risk assessment was conducted for conventionally derived and plant-cell derived Newcastle disease virus vaccine. Effect and exposure scenarios were modeled for each quantitative risk assessment and each scenario was based on a tiered approach in which inadvertent exposure through ingestion were examined to determine a risk characterization of the plant-based pharmaceuticals. The qualitative Newcastle disease virus vaccine risk assessment characterized risks based on the potential exposures to the poultry being vaccinated, to humans administering the vaccine, and to non-target birds. For the human-health risk assessment, the dietary exposure evaluation model (DEEM) was used to estimate the inadvertent dietary intake of the pharmaceutical proteins in food. The ecological risk assessment used Monte Carlo simulations to evaluate the exposure of each protein in maize for four receptor species. The human-health risk assessments revealed that the most conservative scenario produced higher risk quotients (RQ's) than the other two scenarios. The difference in risks was attributable to the differences in toxic endpoints of the proteins. Although the protein expressions and dietary consumption were assumed to be the same, dietary risks between the proteins varied by more than 56,000 times. The human-health risk assessment revealed that risks will vary dramatically and depend on factors such as the specific pharmaceutical protein, protein expression, and exposure scenarios. The assessments reinforced the need for case-by-case assessments. The ecological risk assessment demonstrated that risks will vary between species and between proteins, based primarily on differences in toxic endpoint and consumption rates. It shows the utility of probabilistic, quantitative risk assessment methodologies and supports the human dietary risk assessment by demonstrating the importance of assessing risks from plant-based pharmaceuticals on a case-by-case basis. The qualitative assessment illustrated that fewer effects and contamination issues were associated with the use of the plant-cell derived Newcastle disease virus vaccine compared to conventionally derived vaccines.
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Nedwin, Glenn E. "Development of a business plan for a recombinant DNA technology based pharmaceutical company." Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/14846.
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Parisi, Ann Margaret. "Investigation of Secondary Metabolite Production in Selected Australian Native Species via Plant Cell Suspension Culture." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/366129.
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Natural products and natural-product-derived substances comprised about
35% of the total pharmaceuticals market volume of US$230 billion in 1996
(Wessjohann, 2000). The success of natural-based drugs can be attributed to
nature’s ability to induce effects by chemical means and many of these chemicals
are able to pass species boundaries to cause an effect. Since plant secondary
metabolites have evolved in the interaction with other organisms, many of them
have interesting biological or therapeutical activities that are useful to man. In
addition to their intriguing chemistry a number of these compounds are
economically important, serving as pharmaceuticals, aromatics, fragrances,
stimulants, colours and pesticides.
Plant cell culture is viewed as a potential means of producing useful plant
products without the inherent problems associated with conventional agriculture.
Undifferentiated cell suspension cultures have the potential to produce varied
secondary metabolites by the alteration of culture conditions or addition of
chemicals to elicit expression of different metabolic pathways. Suitable substrate
compounds may be biotransformed to a desired product using plant cell cultures.
Biotransformation can produce compounds that can then be replicated by
synthetic means or produce novel compounds that have previously not been
identified or recognised as important. This thesis describes the initiation of plant
suspension cultures for the purposes of examining the production of secondary
metabolites of selected Australian native rainforest species.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Science
Science, Environment, Engineering and Technology
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Ahmadi, Fard Ala. "Ebola hemorrhagic fever: outbreaks, modeling, and vaccine development." Kansas State University, 2016. http://hdl.handle.net/2097/32649.
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Master of ScienceDepartment of Biological & Agricultural Engineering
Caterina M. Scoglio
Lisa R. Wilken
Between the years 2014 and 2015, the world experienced a catastrophic outbreak of Ebola virus, which killed over 26,000 people. Several authorities and organizations actively participated in fighting the epidemic. Infectious disease modelers proved to be invaluable towards this goal. This report provides a background on the Ebola epidemic in West Africa and reviews the biological features of the Ebola virus. Moreover, this report applies a new model for Ebola propagation using data collected by the World Health Organization during the span of the outbreak. The model estimates the reproduction number and assesses the role of mitigation strategies in slowing down the progress of the disease. The report also concludes a review of recent advancements in vaccine production against Ebola.
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Calhoun, McKenzie L. "Gauging Student Knowledge Base and Creating a Plan to Address Deficits." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/6902.
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Miller, Erin Suzanne. "Increasing Expression of Hepatitis B Surface Antigen in Maize through Breeding." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1359.
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The hepatitis B virus (HBV) is a common virus, with two billion people infected worldwide. It causes approximately 600,000 deaths each year, despite the availability of an effective vaccine since 1982. Maize as a platform for oral vaccination can supply a heat stable vaccine, which does not require syringes or trained personnel to administer. The Hepatitis B Surface antigen was transformed into maize and this seed was used to evaluate expression levels through the breeding process. The transgene was transferred into two elite maize inbreds by backcrossing. Highest expressing ears were selected each generation until approximately 99% commercial parent was obtained with a single gene coding for the vaccine present. Selected individuals were crossed to create hybrid plants. This work was done to create high expressing high yielding lines that could be used as a plant-based oral vaccine for Hepatitis B.
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Almeida, Mônica Batista de. "Prospecção tecnológica de óleos essenciais de Schinus terebinthifolius e desenvolvimento de um creme vaginal à base de Ocimum basilicum para tratamento de candidíase." Pós-Graduação em Biotecnologia, 2013. https://ri.ufs.br/handle/riufs/3308.
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Vaginal candidiasis is a disease with high prevalence in adult women. This study aimed to : ( i ) assess the antiCandida activity of essential oil ( EO ) of S. terebinthifolius front lines of cases of recurrent vaginal candidiasis ; ( II ) produce a antiCandida vaginal cream from OE O. basilicum and evaluate the technological process and this cream antiCandida activity in vitro . The major compounds of OE leaves and dried fruits of S. Terebinthifolius were, respectively, the (+) - camphene (20.1%) and R- ? - pinene (22.1%). In terms of minimum inhibitory concentration (MIC ) and minimum fungicidal , OE Fruit S. terebinthifolius showed bands between 25-200 mg / ml , demonstrating activity against C. parapsilosis ( ATCC 22019 ) and a clinical strain , C. albicans (ATCC 18804) and C. glabrata (ATCC 2001) , not being active on these clinical isolates. Regarding OE leaves, no significant action was observed. The OE dried fruit showed fungistatic , however , no fungicide both OE action, in contrast, leaves and fresh fruits showed antiCandida activity, unless the standard strain of C. glabatra the essential oil from fresh fruits . The major compound of OE O. basilicum (Maria - Bonita) was linalol (72.08%). MIC values ranged between this SO 0.78 to 1.56 mg / ml. Before its antifungal action, was produced a vaginal cream. The samples were stored in these distinct conditions: controlled, refrigerator and oven temperature. In controlled and cooler temperatures, no changes in the formula, however, samples at 45 ° C showed slight changes in texture from the 15th day. It can be concluded that the EO of dried leaves and fruits of S.terebinthifolius Raddi not have antiCandida activity, however, the EO extracted from fresh material Botanical demonstrate such activity . The O. basilicum presents antiCandida action. Tests for antimicrobial activity of vaginal cream in its various concentrations showed satisfactory results compared to a synthetic antifungal.Keywords: Vaginal candidiasis, essential oils, Candida spp., Schinus terebinthifolius Raddi, Ocimum basilicum, vaginal cream, anti-candida.A candidíase vaginal é uma doença com alta prevalência em mulheres na idade adulta. Este trabalho teve como objetivos: (I) avaliar a atividade antiCandida do óleo essencial (OE) de S. terebinthifolius frente a linhagens de casos de candidíase vaginal recorrente; (II) produzir um creme vaginal antiCandida a partir do OE do O. basilicum e avaliar o processo tecnológico e a atividade antiCandida deste creme in vitro. Os compostos majoritários do OE das folhas e frutos secos de S. terebinthifolius, foram respectivamente, o (+) -Camphene (20,1%) e o R-?-pinene (22,1%). Em se tratando das concentrações inibitórias mínimas (CIM) e fungicidas mínimas, o OE do fruto de S. terebinthifolius apresentou faixas entre 25 - 200 mg/ml, demonstrando atividade contra C. parapsilosis (ATCC 22019) e sua linhagem clínica, C. albicans (ATCC 18804) e C. glabrata (ATCC 2001), não sendo ativo aos isolados clínicos destas. Em relação ao OE das folhas, nenhuma ação significativa foi observada. O OE dos frutos secos apresentou ação fungistática, porém, não houve ação fungicida de ambos os OE, em contrapartida, as folhas e frutos frescos apresentaram atividade antiCandida, salvo, a linhagem padrão de C. glabatra pelo óleo essencial dos frutos frescos. O composto majoritário do OE de O. basilicum (Maria-Bonita) foi o linalol (72,08%). Os valores das CIM deste OE variaram entre 0,78 a 1,56 mg/ml. Diante de sua ação fungicida, foi produzido um creme vaginal. As amostras deste foram armazenadas em condições distintas: temperatura controlada, refrigerador e estufa. Em temperatura controlada e refrigerador, não houve modificações na fórmula, entretanto, as amostras à 45º C, apresentaram modificações leves na textura a partir do 15º dia. Pode-se concluir que os OE de folhas e frutos secos da S.terebinthifolius Raddi não apresentam atividade antiCandida, porém, os OE extraídos do material botânico fresco demonstram tal atividade. O O. basilicum apresenta ação antiCandida. Os testes de atividade antimicrobiana do creme vaginal em suas concentrações distintas demonstraram resultados satisfatórios em comparação a um antifúngico sintético. Palavras-Chave: Candidíase vaginal, óleos essenciais, Candida spp., Schinus terebinthifolius Raddi, Ocimum basilicum, creme vaginal, anti-Candida.
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Fang, Jei-Wein, and 方瑞文. "The Performance-Based Design of Sprinkler Systems in Temporary Chemical Storage Areas of Multi-Function Active Pharmaceutical Ingredient Plants." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/95103672044617452816.
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碩士長榮大學
職業安全與衛生研究所(在職專班)
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Biotechnology is a leading and important industry in the 21st century. It will also be one of the major industrial developments in Taiwan. Taiwan government focuses on promoting the development of the biotechnology industry in recent years. The biotechnology industry is deeply bound up with the health of people, and it also has many advantages, such as the technological concentrated and the capital concentrated enhancements, less pollution, and a high reward on investment. Many of the flammable organic chemicals are used in the production process of the multi-function active pharmaceutical ingredient plants in biotechnology industry. They place the chemicals close to the production line, and put 53 gallon drums in the corridor for the convenience of production process in the existing active pharmaceutical ingredient plant. Because the corridor is set up the sprinkler system for protection, the performance-based design of sprinklers in corridors should be studied in order to establish the new safety norms for multi-function active pharmaceutical ingredient plants. In this study, we simulated the sprinkler actuation for the chemicals temporary storage corridor of multi-function active pharmaceutical ingredient plant in accordance with the actual situation. The simulation software was FDS (Fluid Dynamics Simulator). The simulation included standard sprinklers, quick response sprinklers, early suppression fast-response (ESFR) sprinklers, raising the height of sprinklers, adding the sidewall sprinklers and additional compartments for assessing the results of improvement. The chemicals temporary storage corridor of multi-function active pharmaceutical ingredient plant should set up the outlet slope to prevent vapor cloud explosion that may cause sprinkler system failure from this research. Building an additional compartment and adding sprinklers in the compartment ceiling are the best improvement method for 55 gallons drum fires. The best selection of sprinkler in the compartment ceiling is ESFR sprinkler. So, the existing multi-function active pharmaceutical ingredient plant should set up the outlet slope in the chemicals temporary storage corridor and add ESFR sprinklers in the compartment. This improvement would prevent fire explosion and decrease the risk of temporary storage area. In conclusion, this study proposes that new multi-function active pharmaceutical ingredient plants should set up a temporary storage area at outdoor in order to constrain and decrease the fire hazards. New multi-function active pharmaceutical ingredient plants are proposed to set up explosion-proof equipments for avoiding the occurrence of fire explosion. In the temporary storage area, the chemicals should be controlled in the 8-hour or one shift for minimizing the amount of storage. To achieve the purpose of safe production, the hot work permit management should be built. The staffs and contractors should be trained about safety awareness continually in multi-function active pharmaceutical ingredient plants.
Books on the topic "Plant Based Pharmaceutical"
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W, Lininger Schuyler, Gaby Alan, Batz Forest, Austin Steve 1947-, Brown Don 1956-, and Yarnell Eric, eds. Clinical essentials: Science-based reference of complementary and alternative medicine. Portland, OR: Healthnotes, 2000.
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Office, General Accounting. Medicaid: Three states' experiences in buying employer-based health insurance : report to the Chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.
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Office, General Accounting. Medicaid: Three states' experiences in buying employer-based health insurance : report to the chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.
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Sabiu, Saheed, ed. Therapeutic Use of Plant Secondary Metabolites. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150506221220101.
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The book is an evidence-based reference about biochemical mechanisms of action of plant secondary metabolites. It conveys an understanding about how plant-based therapies work, and explains their role in the treatment of complementary and alternative medicine for in the treatment of diabetes, cancer, neurodegenerative disorders, microbial infections, etc., The 15 chapters are written by eminent scholars, lecturers, and experts in indigenous knowledge systems (IKS), industrial and medicinal plants, phytotherapeutics, and phytoinformatics. Reports on health benefits of specific phytochemicals are also highlighted. In addition to basic concepts in medicinal chemistry and ethnopharmacology, the book covers the role of modern computer techniques in developing new pharmaceuticals from plat sources. Therapeutic Uses of Plant Secondary Metabolites is timely and valuable reference for both undergraduate and postgraduate students in medicinal chemistry, as well as researchers and professionals in IKS, phytomedicine, ethnopharmacology, phytopharmacology, plant biotechnology, drug discovery and development, and phytotherapeutics.
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Perera, S. A. C. N., and L. D. Amarasinghe, eds. Marching Towards a Bioeconomy. Institute of Biology, Sri Lanka, 2021. http://dx.doi.org/10.31357/bks.faps.00001.
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Bioeconomy has evolved as a solution to economic, social and environmental problems within and across all the sectors of world economies. It has brought about the materials technology shift from synthetics to bio-based raw materials to introduce sustainable technologies. Activities in the bioeconomy primarily involve the production of biomass from plants, animals, microorganisms and its conversion into bio-based products. Agriculture is a major component in a bioeconomy. Countries with a larger landmass have a competitive advantage in biomass production through agriculture hence a larger bioeconomy. Sri Lanka, with its limited land availability, cannot expand the land further for biomass production through traditional agriculture. The bioeconomy of Sri Lanka therefore have to move beyond traditional agriculture pursuing more scientific approaches for biomass production and conversion. The use of crops as a renewable industrial feedstock and the application of biotechnology are, therefore, indispensable for the implementation of sustainable development strategies in the country. The rich biodiversity on land and the sea of the country is still underutilized and has a great potential to be used in the pharmaceutical and biotechnology industries. There is a pressing need in the country to create a motivated society to pursue the promising prospects offered by the bioeconomy in development.
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Kumar Sharma, Mukesh, and Pallavi Kaushik, eds. Therapeutic Implications of Natural Bioactive Compounds. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/97898150800251220301.
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This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable population groups. Chapters in the book incorporate the knowledge based on traditional medicine with recent findings on bioactive molecules and their pharmaceutical implications in neurodegenerative diseases, cancer, COVID 19, diabetes, immunomodulation and farm animal diseases. The book also highlights the latest breakthroughs in the field of screening, characterization, and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, algae, fungi, higher plants, and marine sources. Authors from renowned institutions of India, Japan and China have shared their expertise in the contributed chapters with the goal of enhancing readers knowledge about the significance of use of bioactives in therapeutics and nutraceuticals. It is an informative reference for researchers, professors, graduate students, science enthusiasts, and all those who wish to gain insights into various aspects of bioactive compounds and development of new pharmacological active constituents and nutritional science.
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O'Hagan, Anthony, and Mike West, eds. The Oxford Handbook of Applied Bayesian Analysis. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198703174.001.0001.
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This handbook discusses various applications of modern Bayesian analysis in important and challenging problems. With contributions from leading researchers and practitioners in interdisciplinary Bayesian analysis, the book highlights current frontiers of research in each application. Each chapter involves a concise review of the application area, describes the problem contexts and goals, discusses aspects of the data and overall statistical issues, and offers detailed analysis with relevant Bayesian models and methods. The book is organised into five sections based on the field of application, namely: Biomedical and Health Sciences; Industry, Economics and Finance; Environment and Ecology; Policy, Political and Social Sciences; and Natural and Engineering Sciences. Topics range from an epidemiological study involving pregnancy outcomes, to matching and alignment of biomolecules; pharmaceutical testing from multiple clinical trials concerned with side-effects and adverse events; malaria mapping in the Amazon rain forest; risk assessment of contamination of farm-pasteurized milk with the bacterium Vero-cytotoxigenic E. coli (VTEC) O157; Bayesian analysis and decision making in the maintenance and reliability of nuclear power plants; risk modelling regarding speculative trading strategies in financial futures markets; the use of hierarchical models to characterize the uncertainty of climate change projections; and the use of multistate models for mental fatigue.
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Medicaid: Three states' experiences in buying employer-based health insurance : report to the chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.
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VA health care: Third-party charges based on sound methodology; implementation challenges remain : report to the chairmen and Ranking Minority Members, Committees on Veterans' Affairs, U.S. Senate and House of Representatives. Washington, D.C: The Office, 1999.
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VA health care: Third-party charges based on sound methodology; implementation challenges remain : report to the chairmen and Ranking Minority Members, Committees on Veterans' Affairs, U.S. Senate and House of Representatives. Washington, D.C: The Office, 1999.
Find full textBook chapters on the topic "Plant Based Pharmaceutical"
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Joon, Shikha, Enty Tjoa, Rajeev K. Singla, Rakesh Bhatnagar, and Bairong Shen. "Plant-Based Antimicrobials for Sepsis Management." In Antimicrobials in Pharmaceutical and Medicinal Research, 49–68. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003268932-3.
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So, Kenny K. Y., Michael R. Marit, Michael D. McLean, and J. Christopher Hall. "Chapter 17 Plant-Based Production of Biosimilar Drug Products." In Drugs and the Pharmaceutical Sciences, 439–58. 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2017. http://dx.doi.org/10.1201/9781315119878-18.
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Praveen, Nagella, Ravi Shankar Thenmozhi Preetha, Vishakha Pagare, Jyothis Devasia, Aatika Nizam, Epsita Mukherjee, Veerappa Lakshmaiah Vasantha, and Jameel Mohammed Al-Khayri. "Plant-based Metabolites as Source of Antimicrobial Therapeutics." In Antimicrobials in Pharmaceutical and Medicinal Research, 165–201. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003268932-9.
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McClatchey, Will, and Jodi Stevens. "An Overview of Recent Developents in Bioprospecting and Pharmaceutical Development." In Development of Plant-Based Medicines: Conservation, Efficacy and Safety, 17–45. Dordrecht: Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-015-9779-1_2.
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Adnan, Md, Ki Kwang Oh, Dong Ha Cho, and Madhusudhan Alle. "Nutritional, Pharmaceutical, and Industrial Potential of Forest-Based Plant Gum." In Non-Timber Forest Products, 105–28. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73077-2_5.
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Buntru, Matthias, Simon Vogel, Ricarda Finnern, and Stefan Schillberg. "Plant-Based Cell-Free Transcription and Translation of Recombinant Proteins." In Recombinant Proteins in Plants, 113–24. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2241-4_8.
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AbstractPlant cell-free lysates contain all the cellular components of the protein biosynthesis machinery, providing an alternative to intact plant cells, tissues, and whole plants for the production of recombinant proteins. Cell-free lysates achieve rapid protein production (within hours or days) and allow the synthesis of proteins that are cytotoxic or unstable in living cells. The open nature of cell-free lysates and their homogeneous and reproducible performance is ideal for protein production, especially for screening applications, allowing the direct addition of nucleic acid templates encoding proteins of interest, as well as other components such as enzyme substrates, chaperones, artificial amino acids, or labeling molecules. Here we describe procedures for the production of recombinant proteins in the ALiCE (Almost Living Cell-free Expression) system, a lysate derived from tobacco cell suspension cultures that can be used to manufacture protein products for molecular and biochemical analysis as well as applications in the pharmaceutical industry.
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Ferreira, Ana R., Nazaré Couto, Paula R. Guedes, Eduardo P. Mateus, and Alexandra B. Ribeiro. "Removal of Pharmaceutical and Personal Care Products in Aquatic Plant-Based Systems." In Electrokinetics Across Disciplines and Continents, 351–72. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20179-5_18.
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Chebouba, Billal Nazim, Mohamed Arezki Mellal, and Smail Adjerid. "Multi-objective Reliability Optimization of a Pharmaceutical Plant by NSGA-II." In Proceeding of 2021 International Conference on Wireless Communications, Networking and Applications, 250–56. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2456-9_27.
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AbstractThis work addresses the use of a MO optimization algorithm to deal with the reliability optimization problem in order to determine the redundancy and reliability of each component in the system. Often, these problems are formulated as a single-objective problem with mixed variables (real-integer) and is subject to various design constraints. Classical solution approaches were limited to deal with these problems and most recent solution approaches are based on nature-inspired optimization algorithms which belong to artificial intelligence (AI). In the present paper, the problem is solved as a MO optimization problem through the Non-dominated Sorting Genetic Algorithm II (NSGA-II) to generate the set of optimal solutions, also called Pareto. The latter helps the decision-maker. The case studied consists of a pharmaceutical plant.
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Hundleby, Penny A. C., Marc-André D’Aoust, Carolyn Finkle, Judith Atkins, and Richard M. Twyman. "Regulation of Molecular Farming Products." In Recombinant Proteins in Plants, 313–33. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2241-4_17.
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AbstractThe regulation of molecular farming is a complex topic because plants and plant-based systems are relative newcomers among the many production platforms available for recombinant proteins. The regulations specific for different types of product (human/veterinary pharmaceuticals and medical devices, cosmetics, diagnostics, and research reagents) must therefore be overlaid with the regulations governing hitherto unfamiliar production platforms, and this must be achieved in different jurisdictions that handle genetically modified organisms (and genetically modified plants in particular) in very different ways. This chapter uses examples of different product types and production methods in three different jurisdictions (the USA, the EU, and Canada) to demonstrate some of the challenges facing the regulatory authorities.
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Sahana, Basudev, and Kuhu Bhaduri. "Pharmaceutical Formulation Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health-Care Services." In Evidence Based Validation of Traditional Medicines, 767–98. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8127-4_37.
Full textConference papers on the topic "Plant Based Pharmaceutical"
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Negreanu-Pirjol, Ticuta. "PHARMACEUTICAL FORMULATIONS BASED ON INDIGENE MEDICINAL PLANT EXTRACTS WITH ANTIOXIDANT ACTIVITY." In 15th International Multidisciplinary Scientific GeoConference SGEM2015. Stef92 Technology, 2015. http://dx.doi.org/10.5593/sgem2015/b61/s25.068.
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Du, Zhao, Wenxia Zhao, Bin Guo, and Ailing Ren. "Study and Application of Iron-Based Deodorant Prepared by Pyrite Slag for Removing Odour from Pharmaceutical Wastewater Treatment Plant." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516511.
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Zammouri, Amel, N. Boudhrioua Mihoubi, and N. Kechaou. "Comparison between bubbling and turbulent regime for the simulation of batch pharmaceutical powders fluidized bed drying." In 21st International Drying Symposium. Valencia: Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/ids2018.2018.7703.
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The two-phase theory has been frequently used to model fluidised bed drying. At high air velocities, a transition from the bubbling regime to the turbulent regime may occur. In this work, we compare a bubbling model and a turbulent model for the simulation of a two pharmaceutical powders drying in a pilot plant and an industrial plant fluidised bed. The bubbling model was based on a discrete variable bubble size. Heat and mass transfer coefficients were based on the Kunii and Levenspiel correlation [1]. Flow regime was supposed to be completely mixed for the emulsion phase. For the turbulent model, the bubble size is not anymore discrete but continuous and bubble phase is less distinguishable than in the bubbling regime. Heat and mass transfer were those proposed by Foka[2]. In addition, the freeboard section was considered since high entrainment is specific of this regime. Gas backmixing was taken into account by considering a plug flow with axial dispersion for the interstitial gas flow. The bubble phase being dilute, was modeled by a plug flow. A plug flow was also considered for the freeboard gas. The solid phase was supposed to be completely mixed. The bubbling regime simulation gave good agreement with experiment in the case of the pilot plant experiment, while the turbulent model better simulated the industrial scale experiment. Key words: batch fluidized bed, pharmaceutical powder, drying, modeling, bubbling, turbulent
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De Lucia, Maurizio, Carlo Carcasci, and Antonio Matucci. "Thermoeconomic Analysis and Optimization of a Gas Turbine Plant Combined With an Absorption Unit." In ASME 1997 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/97-gt-175.
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The aim of the paper is to study the performance of a power plant for the combined production of electrical, thermal and cooling thermal energy. The exergy analysis was developed from the system’s operating conditions measured in a previous experimental phase, and allowed description and quantification of causes of efficiency loss in the plant. The following thermoeconomic analysis, based on the exergy balance, allowed appraisal of the actual costs of each component and possible optimization of the plant for higher efficiency and cost saving. The thermoeconomic results lead to a better understanding of the influence of off-design operating conditions on the performance of the whole plant and on this basis further improvements and modifications are envisaged. Three modifications of the plant layout are described and discussed, in greater detail for the most promising of them, i.e., compressor inlet air cooling with absorber excess cooling power production. Results show that this solution is particularly effective in the present case, not only from the energetic point of view, but, as is not always the case, also form the economic one. The application of thermoeconomic analysis to the pharmaceutical factory under study has the aim of identifying those components which have the highest cost quantifying losses in cost terms.
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De Lucia, Maurizio, Carlo Lanfranchi, and Antonio Matucci. "A Small Gas Turbine Plant for Cogeneration of Electricity, Thermal and Cooling Thermal Energy With an Absorption Unit." In ASME 1997 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/97-gt-174.
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A cogeneration plant with a small gas turbine was installed in a pharmaceutical factory and instrumented for acquiring all the values necessary to appraise both its energetic and cost advantages. The plant was designed and built as a demonstrative project under a program for energy use improvement in industry, partially financed by the European Union. The system comprises as its main components: 1) a gas turbine cogeneration plant for production of power and thermal energy under the form of hot water, superheated water, and steam; 2) a two-stage absorption unit, fueled by the steam produced in the cogeneration plant, for production of cooling thermal energy. The plant was provided with an automatized control system for the acquisition of plant operating parameters. The large amount of data thus provided made it possible to compare the new plant, under actual operating conditions, with the previously existing cooling power station with compression units, and with a traditional power plant. This comparative analysis was based on measurements of the plant operating parameters over nine months, and made it possible to compare actual plant performance with that expected and ISO values. The analysis results reveal that gas turbine performance is greatly affected by part-load as well as ambient temperature conditions. Two-stage absorber performance, moreover, turned out to decrease sharply and more than expected in off-design operating conditions.
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Jia, Yongzhong, and T. Agami Reddy. "A Model-Based Feed-Forward Controller Scheme for Accurate Chilled Water Temperature Control of Inlet Guide Vane Centrifugal Chillers." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33343.
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Capacity control in most commercial centrifugal chillers is achieved by inlet guide vanes, which are activated by the leaving chilled water temperature sensor. Due to mechanical reasons, vane control is done discretely, and not continuously. The control module compares the value provided by the temperature sensor to pre-set control band values, and if those bands are exceeded, it sends a signal to the vane control motor to adjust the vane position by one step that could be upwards or downwards. The advantage of this type of discrete control method is its simplicity. Normally, the accuracy in the outlet chilled water temperature is of the order of 0.5°C, which is acceptable for normal cooling plants such as used in office buildings. However, there are applications such as in pharmaceutical processes, mechanics labs, or instances in chemical processes where more accurate control is required (sometimes as low as 0.05°C). This paper proposes a simple method to achieve such tight control without any hardware modifications. The basis of this method is a transient physical inverse model of the refrigerant boiling process in the evaporator, in conjunction with a feed-forward control scheme. The model parameters need to be identified from monitored data since they are chiller-specific. This paper describes the model, and applies it to one-minute monitored data from an actual chiller plant of 1580 kW (450 Tons). It is demonstrated that for this specific chiller such a control scheme has the potential to improve control accuracy by about 28% as compared to the traditional control method.
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Sahoo, Debasish, Virendra Vaishnav, Tanushree Chatterjee, and Navita Gupta. "HERBAL DIETARY SUPPLEMENT – A MODERN APPROACH IN COMPLEMENTARY AND ALTERNATIVE MEDICINE (CAM) IN HEALTH CARE SCIENCE." In International Conference on Public Health and Medical Sciences. Goodwood Conferences, 2022. http://dx.doi.org/10.35912/icophmeds.v1i1.24.
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Preliminary pharmacological study of herbal based dietary supplement formulation based on extracts or whole plants derived from fruits, root, berries, macrofungus and leaves as a promising, safe and effective alternative to synthetic and pharmaceutical dietary supplements, in-vitro studies such as antibacterial, anti-oxidant and anti-inflammatory activity for extract of dietary supplements. Nutritional assessment of nutritional attributes as suggested by AOAC method, Phytochemical analysis by standard chemical procedures, Quantitative estimate Alkaloid, Flavonoid, Phenolic, Tannin. In-vitro studies of anti-microbial (well diffusion), anti-oxidant assay (DPPH assay), anti-inflammatory assay (albumin denaturation assay). FTIR analysis for detection of different functional group. The finding suggest that the plant extract have a better nutritional aspect. The extracts for the food supplement showed positive results for anti-microbial, anti-oxidant and anti-inflammatory activity. More studies has to be concluded in respect to in-vivo tests that will conclude other pharmacological aspect of the food supplements. Reduced concentration of heavy metals and other contaminants will increase the therapeutical potency of the supplement. Stability, hold time study, dose and dosage form must be concluded in respect to achieve maximum efficacy. The herbal dietary supplement tend to better option against chemical based multi-vitamins and dietary supplements. These will enact the general well-being along with other pharmacological activities due to presence of phytochemicals present in the supplement.
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Farrell, Paul, and Philip R. LeGoy. "Using Plasma Pyrolysis Vitrification (PPV) to Enhance Incineration Waste Ash Reduction in Ireland." In 10th Annual North American Waste-to-Energy Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/nawtec10-1028.
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Ireland has been called the Silicon Valley of Europe. Like the Silicon Valley in the U.S. it has a large amount of waste created by the Microchip Industry. Ireland is also an agricultural country. A large amount of bio-waste has been stockpiled in Ireland. This is the result of recent outbreaks/epidemics of animal diseases in the EU. The current growth industry of Ireland is the chemical and pharmaceutical manufacturing industry. Nine of the top ten pharmaceutical companies are manufacturing in Ireland. Wastes from these industries are often toxic and hazardous. They can contain large amounts of combustible organic compounds depending on their source. Since Ireland is an island it has special problems disposing of waste. Waste comes in as products as packaging and it doesn’t go out. The emerging solution is Incineration. Municipal Solid Waste (MSW) can contain many forms of metal and chemistry under normal conditions. When a large amount of the primary industry of a region is chemistry based and agricultural based there is the probability of more than usual amount of toxic residue in the refuse. The ash from incineration contains items such as dioxins & heavy metals that are environmental toxins. Using a Plasma Pyrolysis Vitrification (PPV) process the volume of the resultant ash from incineration can be further reduced by as much as 30 to 1. A PPV process has an added advantage of giving an incineration facility the capability of rendering ash safe for reuse as construction material and as a side benefit reclaiming many valuable elemental components of the ash. The PPV plant can be used to destroy waste directly and economically as long as the gate fees are high. One byproduct of incinerator ash smelting/destruction using a PPV process is CO gas, a combustible fuel resource for power generation. Precious metals may also be reclaimed as an alloy material by-product.
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Srećković, Nikola Z., Jelena S. Katanić Stanković, and Vladimir B. Mihailović. "PHENOLIC CONTENT AND POTENTIAL APPLICATION OF „LYSIMACHIA VULGARIS“ L. AERIAL PART AND ROOT EXTRACTS." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.395s.
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Lysimachia vulgaris L., also known as yellow loosestrife, is an herbaceous perennial flowering plant from the family Primulaceae. Traditionally, L. vulgaris has been commonly used in Chinese medicine to increase urination, reduce fever, and treat sexually transmitted ailments. This study aimed to investigate phenolic content, antioxidant activity, and antimicrobial potential of L. vulgaris aerial part (LVA) and root (LVR) methanol extracts. Based on the spectrophotometric determination, both extracts possessed a high level of phenolic compounds. The content of total phenolic compounds (130.14 mg GAE/g) and condensed tannins (120.58 mg GAE/g) was higher in LVR, while total flavonoid (206.93 mg QUE/g) and flavanol (17.02 RUE/g) contents were higher in LVA. DPPH and ABTS assays were used to estimate the antioxidant activity of the extracts, whereby LVR showed better antioxidant potential in both applied methods. The extracts inhibited the growth of most of the tested bacterial and fungal strains with minimal inhibitory concentration values (MICs) ranged between (˂ 0.3125 to 20 mg/mL), whereby the significantly higher antimicrobial activity of LVR was observed. Based on the obtained results, the significant antioxidant and antimicrobial activity of L. vulgaris root extract may be a basis for its further research and potential application in the pharmaceutical and food industry.
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Garcia-Rodriguez, E., and M. Rodriguez-Martinez. "WAMDAS: A Web Service-Based Wireless Alarm Monitoring and Data Acquisition System for Pharmaceutical Plants." In Advanced Int'l Conference on Telecommunications and Int'l Conference on Internet and Web Applications and Services (AICT-ICIW'06). IEEE, 2006. http://dx.doi.org/10.1109/aict-iciw.2006.205.
Full textReports on the topic "Plant Based Pharmaceutical"
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Chefetz, Benny, and Jon Chorover. Sorption and Mobility of Pharmaceutical Compounds in Soils Irrigated with Treated Wastewater. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7592117.bard.
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Research into the fate of pharmaceutical compounds (PCs) in the environment has focused on aspects of removal efficiency during sewage treatment, degradation in surface water and accumulation in soils and sediments. However, very little information is available on the binding interactions of pharmaceuticals with dissolved organic matter (DOM) originating from wastewater treatment. Such interactions can significantly affect the transport potential of PCs in soils by altering compound affinity for soil particle surfaces. Our primary hypothesis is that the transport potential of PCs in soils is strongly impacted by the type and strength of interaction with DOM and the stability of resulting DOM-PC complexes. The overarching goal of the proposed work is to develop a better understanding of the risk associated with introduction of PCs into the environment with treated wastewater. This goal has been achieved by elucidating the mechanisms of the interaction of selected pharmaceuticals (that have shown to be widespread wastewater contaminants) with DOM constituents; by determining the stability and fate of DOM-PC complexes introduced to soils and soil constituents; and by evaluating the potential uptake of these compounds by plants. Based on the results obtained in this study (column and batch sorption-desorption experiments), we suggest that PCs can be classified as slow-mobile compounds in SOM-rich soil layers. When these compounds pass this layer and/or are introduced into SOM-poor soils, their mobility increases significantly. Our data suggest that in semiarid soils (consisting of low SOM), PCs can potentially be transported to the groundwater in fields irrigated with reclaimed wastewater. Moreover, the higher mobility of the acid PCs (i.e., naproxen and diclofenac) in freshwater column systems suggests that their residues in soils irrigated with reclaimed wastewater can leach from the root zone and be transported to the groundwater after rain events. Our data obtained from the binding experiments of PCs with DOM demonstrate that the hydrophobic DOM fractions were more efficient at sorbing PCs than the more polar hydrophilic fractions at a pH near the pKa of the analytes. At the pH of natural semiarid water and soil systems, including that of reclaimed wastewater and biosolids, the role of the hydrophobic fractions as sorption domains is less important than the contribution of the hydrophilic fractions. We also hypothesize that the DOM fractions interact with each other at the molecular level and do not act as independent sorption domains. In summary, our data collected in the BARD project demonstrate that the sorption abilities of the DOM fractions can also significantly affect the mobility of pharmaceutical compounds in soils influenced by intensive irrigation with treated wastewater or amended with biosolids.
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Chefetz, Benny, and Jon Chorover. Sorption and Mobility of Pharmaceutical Compounds in Soils Irrigated with Treated Wastewater. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7709883.bard.
Full textAbstract:
Research into the fate of pharmaceutical compounds (PCs) in the environment has focused on aspects of removal efficiency during sewage treatment, degradation in surface water and accumulation in soils and sediments. However, very little information is available on the binding interactions of pharmaceuticals with dissolved organic matter (DOM) originating from wastewater treatment. Such interactions can significantly affect the transport potential of PCs in soils by altering compound affinity for soil particle surfaces. Our primary hypothesis is that the transport potential of PCs in soils is strongly impacted by the type and strength of interaction with DOM and the stability of resulting DOM-PC complexes. The overarching goal of the proposed work is to develop a better understanding of the risk associated with introduction of PCs into the environment with treated wastewater. This goal has been achieved by elucidating the mechanisms of the interaction of selected pharmaceuticals (that have shown to be widespread wastewater contaminants) with DOM constituents; by determining the stability and fate of DOM-PC complexes introduced to soils and soil constituents; and by evaluating the potential uptake of these compounds by plants. Based on the results obtained in this study (column and batch sorption-desorption experiments), we suggest that PCs can be classified as slow-mobile compounds in SOM-rich soil layers. When these compounds pass this layer and/or are introduced into SOM-poor soils, their mobility increases significantly. Our data suggest that in semiarid soils (consisting of low SOM), PCs can potentially be transported to the groundwater in fields irrigated with reclaimed wastewater. Moreover, the higher mobility of the acid PCs (i.e., naproxen and diclofenac) in freshwater column systems suggests that their residues in soils irrigated with reclaimed wastewater can leach from the root zone and be transported to the groundwater after rain events. Our data obtained from the binding experiments of PCs with DOM demonstrate that the hydrophobic DOM fractions were more efficient at sorbing PCs than the more polar hydrophilic fractions at a pH near the pKa of the analytes. At the pH of natural semiarid water and soil systems, including that of reclaimed wastewater and biosolids, the role of the hydrophobic fractions as sorption domains is less important than the contribution of the hydrophilic fractions. We also hypothesize that the DOM fractions interact with each other at the molecular level and do not act as independent sorption domains. In summary, our data collected in the BARD project demonstrate that the sorption abilities of the DOM fractions can also significantly affect the mobility of pharmaceutical compounds in soils influenced by intensive irrigation with treated wastewater or amended with biosolids.
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Borch, Thomas, Yitzhak Hadar, and Tamara Polubesova. Environmental fate of antiepileptic drugs and their metabolites: Biodegradation, complexation, and photodegradation. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597927.bard.
Full textAbstract:
Many pharmaceutical compounds are active at very low doses, and a portion of them regularly enters municipal sewage systems and wastewater-treatment plants following use, where they often do not fully degrade. Two such compounds, CBZ and LTG, have been detected in wastewater effluents, surface waters, drinking water, and irrigation water, where they pose a risk to the environment and the food supply. These compounds are expected to interact with organic matter in the environment, but little is known about the effect of such interactions on their environmental fate and transport. The original objectives of our research, as defined in the approved proposal, were to: Determine the rates, mechanisms and products of photodegradation of LTG, CBZ and selected metabolites in waters exposed to near UV light, and the influence of DOM type and binding processes on photodegradation. Determine the potential and pathways for biodegradation of LTG, CBZ and selected metabolites using a white rot fungus (Pleurotusostreatus) and ADP, and reveal the effect of DOM complexation on these processes. Reveal the major mechanisms of binding of LTG, CBZ and selected metabolites to DOM and soil in the presence of DOM, and evaluate the effect of this binding on their photodegradation and/or biodegradation. We determined that LTG undergoes relatively slow photodegradation when exposed to UV light, and that pH affects each of LTG’s ability to absorb UV light, the efficiency of the resulting reaction, and the identities of LTG’sphotoproducts (t½ = 230 to 500 h during summer at latitude 40 °N). We observed that LTG’sphotodegradation is enhanced in the presence of DOM, and hypothesized that LTG undergoes direct reactions with DOM components through nucleophilic substitution reactions. In combination, these data suggest that LTG’s fate and transport in surface waters are controlled by environmental conditions that vary with time and location, potentially affecting the environment and irrigation waters. We determined that P. ostreatusgrows faster in a rich liquid medium (glucose peptone) than on a natural lignocellulosic substrate (cotton stalks) under SSF conditions, but that the overall CBZ removal rate was similar in both media. Different and more varied transformation products formed in the solid state culture, and we hypothesized that CBZ degradation would proceed further when P. ostreatusand the ᵉⁿᶻʸᵐᵃᵗⁱᶜ ᵖʳᵒᶠⁱˡᵉ ʷᵉʳᵉ ᵗᵘⁿᵉᵈ ᵗᵒ ˡⁱᵍⁿⁱⁿ ᵈᵉᵍʳᵃᵈᵃᵗⁱᵒⁿ. ᵂᵉ ᵒᵇˢᵉʳᵛᵉᵈ ¹⁴C⁻Cᴼ2 ʳᵉˡᵉᵃˢᵉ ʷʰᵉⁿ ¹⁴C⁻ᶜᵃʳᵇᵒⁿʸˡ⁻ labeled CBZ was used as the substrate in the solid state culture (17.4% of the initial radioactivity after 63 days of incubation), but could not conclude that mineralization had occurred. In comparison, we determined that LTG does not degrade in agricultural soils irrigated with treated wastewater, but that P. ostreatusremoves up to 70% of LTG in a glucose peptone medium. We detected various metabolites, including N-oxides and glycosides, but are still working to determine the degradation pathway. In combination, these data suggest that P. ostreatuscould be an innovative and effective tool for CBZ and LTG remediation in the environment and in wastewater used for irrigation. In batch experiments, we determined that the sorption of LTG, CBZ and selected metabolites to agricultural soils was governed mainly by SOM levels. In lysimeter experiments, we also observed LTG and CBZ accumulation in top soil layers enriched with organic matter. However, we detected CBZ and one of its metabolites in rain-fed wheat previously irrigated with treated wastewater, suggesting that their sorption was reversible, and indicating the potential for plant uptake and leaching. Finally, we used macroscale analyses (including adsorption/desorption trials and resin-based separations) with molecular- level characterization by FT-ICR MS to demonstrate the adsorptive fractionation of DOM from composted biosolids by mineral soil. This suggests that changes in soil and organic matter types will influence the extent of LTG and CBZ sorption to agricultural soils, as well as the potential for plant uptake and leaching.