Academic literature on the topic 'PKC inhibitors'
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Journal articles on the topic "PKC inhibitors"
Saberi, Behnam, Mie Shinohara, Maria D. Ybanez, Naoko Hanawa, William A. Gaarde, Neil Kaplowitz, and Derick Han. "Regulation of H2O2-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes." American Journal of Physiology-Cell Physiology 295, no. 1 (July 2008): C50—C63. http://dx.doi.org/10.1152/ajpcell.90654.2007.
Full textSilva, J. M., M. Hamel, M. Sahmi, and C. A. Price. "Control of oestradiol secretion and of cytochrome P450 aromatase messenger ribonucleic acid accumulation by FSH involves different intracellular pathways in oestrogenic bovine granulosa cells in vitro." Reproduction 132, no. 6 (December 2006): 909–17. http://dx.doi.org/10.1530/rep-06-0058.
Full textLiedtke, Carole M., and Thomas Cole. "Antisense oligodeoxynucleotide to PKC-δ blocks α1-adrenergic activation of Na-K-2Cl cotransport." American Journal of Physiology-Cell Physiology 273, no. 5 (November 1, 1997): C1632—C1640. http://dx.doi.org/10.1152/ajpcell.1997.273.5.c1632.
Full textHu, Hui-Juan, and Robert W. Gereau. "ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. II. Modulation of Neuronal Excitability." Journal of Neurophysiology 90, no. 3 (September 2003): 1680–88. http://dx.doi.org/10.1152/jn.00341.2003.
Full textReilein, Amy R., Irina S. Tint, Natalia I. Peunova, Grigori N. Enikolopov, and Vladimir I. Gelfand. "Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A)." Journal of Cell Biology 142, no. 3 (August 10, 1998): 803–13. http://dx.doi.org/10.1083/jcb.142.3.803.
Full textItoh, Hiroyuki, Shinji Yamamura, J. Anthony Ware, Shaobin Zhuang, Shinsuke Mii, Bo Liu, and K. Craig Kent. "Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration." American Journal of Physiology-Heart and Circulatory Physiology 281, no. 1 (July 1, 2001): H359—H370. http://dx.doi.org/10.1152/ajpheart.2001.281.1.h359.
Full textWilkinson, S. E., and J. S. Nixon. "PKC Inhibitors in the Therapy of Autoimmune Diseases." Current Pharmaceutical Design 2, no. 6 (December 1996): 596–609. http://dx.doi.org/10.2174/1381612802666221004184418.
Full textLiu, Wen, Yuan Wei, Peng Sun, Wen-Hui Wang, Thomas R. Kleyman, and Lisa M. Satlin. "Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C." American Journal of Physiology-Renal Physiology 297, no. 4 (October 2009): F904—F915. http://dx.doi.org/10.1152/ajprenal.90685.2008.
Full textWu, D., I. J. Clarke, and C. Chen. "The role of protein kinase C in GH secretion induced by GH-releasing factor and GH-releasing peptides in cultured ovine somatotrophs." Journal of Endocrinology 154, no. 2 (August 1997): 219–30. http://dx.doi.org/10.1677/joe.0.1540219.
Full textTakahashi, Hideyuki, and Hideo Namiki. "Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors." Biochemical Journal 405, no. 2 (June 27, 2007): 331–40. http://dx.doi.org/10.1042/bj20070299.
Full textDissertations / Theses on the topic "PKC inhibitors"
Aaltonen, V. (Vesa). "PKC and neurofibromin in the molecular pathology of urinary bladder carcinoma:the effect of PKC inhibitors on carcinoma cell junctions, movement and death." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285899.
Full textRatnayake, Wishrawana Sarathi Bandara. "Role of Oncogenic Protein Kinase C-iota in Melanoma Progression; A Study Based on Atypical Protein Kinase-C Inhibitors." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7895.
Full textPanek, Anna [Verfasser]. "Rolle des Connective Tissue Growth Factors (CTGF) und des PKC-enhanced Protein-Phosphatase 1 Inhibitors (KEPI) für die Funktion des adulten Herzen : Studien an transgenen Tiermodellen / Anna Naila Panek." Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1023375095/34.
Full textLakshmanan, Aparna. "Modulation of Sodium Iodide Symporter-mediated Thyroidal Radioiodide Uptake by Small Molecule Inhibitors, Natural Plant-based Products and microRNAs." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429407914.
Full textEsvan, Yannick. "Conception et synthèse de nouveaux composés hétéroaromatiques inhibiteurs potentiels de kinases." Thesis, Clermont-Ferrand 2, 2016. http://www.theses.fr/2016CLF22743.
Full textIn 1950’s protein kinases were found to play a critical role in cell signaling, rising strong research potential for this enzyme family. Initially investigated for their implications in cancerogenesis they were more recently found to be involved in a wide variety of diseases including neurodegenerative pathologies. Herein will be presented two research projects that offer bright new perspectives for the inhibition of kinases involved whether in neurodegenerative diseases or cancers.First, the design and synthesis of new pyrido[3,4-g]quinazoline derivatives will be described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A) that are known to play a potential role in Alzheimer’s disease. The interest for this original tricyclic heteroaromatic scaffold as modulators of CLK1/ DYRK1A activity was validated by nanomolar potencies. CLK1 co-crystal structures with two inhibitors revealed the binding mode of these compounds within the ATP-binding pocket and led to the synthesis of new diversely substituted pyrido[3,4-g]quinazolines.Then the synthesis of a new derivative of the staurosporine aglycon (K252c), in which the lactam ring was replaced by a pyrazole moiety, will be depicted. The resulting indolopyrazolocarbazole inhibited Pim isoforms 1–3 whereas it did not impair the activity of two known targets of K252c, protein kinase C isoforms α and γ . The lead compound exhibited same cytotoxic activity as K252c toward both human leukemia and colon carcinoma cell lines (K562 and HCT116), strongly suggesting that this new scaffold deserves further investigations for treatment of malignancies associated with kinases activities
Trachsel, Sébastien Auguste Charles. "Selective responses (Actin polymerization, shape changes, locomotion, pinocytosis) to the PKC-inhibitor Ro 31-8220 suggest thath PKC discriminately regulates functions of human blood lymphocytes /." [S.l : s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full textMakhoul, Stephanie [Verfasser]. "GPIb-V-IX- and GPVI-specific intracellular signaling and their regulation by PKA/PKG-dependent inhibitory pathways in washed human platelets / Stephanie Makhoul." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1194096891/34.
Full textHofstetter, Barbara. "Klinisch relevante PKC-Inhibitoren als radiosensibilisierende Substanzen für Tumorzellen genaue Untersuchung der Wirkung auf die PI3K/Akt-Signalübermittlungskaskade /." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Departement Angewandte Biowissenschaften, Institut für Pharmazeutische Wissenschaften, 2001. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=5.
Full textHeinzmann, Kathrin. "Investigating the effects or AKT/PKB inhibitors on [18F]-FDG uptake in cancer cells." Thesis, Institute of Cancer Research (University Of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553702.
Full textGottlieb, Rachel. "Use of S. pombe to Characterize Mammalian Adenylyl Cyclases and Their Inhibitors." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104220.
Full textThe study of mammalian cAMP signaling has often been confounded by the fact that ten different genes encode adenylyl cyclases (ACs) that produce cAMP from ATP and 16 different genes encode phosphodiesterases (PDEs) that hydrolyze cAMP to AMP. In this study, mammalian AC cDNAs were cloned and integrated into strains of the fission yeast Schizosaccharomyces pombe that lack their endogenous AC to determine the basal activity of all ten AC isoforms. In addition, response to the stimulatory mammalian Gsα was determined by co-expression of a mutationally-activated form of the human GNAS1 gene. AC activity was assessed using an fbp1-GFP reporter that is repressed by cAMP production and PKA activity. Results confirm that all ten isoforms have detectable basal activity, and AC1-9 definitively respond to Gsα stimulation. When matched with a sufficiently potent mammalian phosphodiesterase (PDE), strains expressing mammalian ACs make good candidates for small molecule high throughput screening (HTS) to detect AC inhibitors. A 100,000 compound screen was recently performed to detect AC and Gsα inhibitors as well as PDE activators. A promising “hit” was progesterone, which has been previously suggested to inhibit ACs in Xenopus. Initial results suggest that progesterone inhibits AC1 and the closely-related AC3. These data demonstrate the utility of using S. pombe as an effective platform for identifying inhibitors of both basal and GNAS1-stimulated AC activity
Thesis (BS) — Boston College, 2015
Submitted to: Boston College. College of Arts and Sciences
Discipline: Departmental Honors
Discipline: Biology
Book chapters on the topic "PKC inhibitors"
Soro-Paavonen, Aino, and Mark Cooper. "Glycosylation Inhibitors, PKC Inhibitors and Related Interventions Against Complications." In Pharmacotherapy of Diabetes: New Developments, 219–28. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-69737-6_20.
Full textYoung, Lindon H., Aisha Phillipson, Didi Omiyi, Norrell Atkinson, Manoj Jivani, Jovan Adams, Ellen E. Peterman, Philip Taormina, Richard J. Brue, and Margaret Harvey. "Protein Kinase C Isoform (PKC) Peptide Activator/Inhibitors Exert Cardioprotective Effects in Polymorphonuclear Leukocyte (PMN)-induced Ischemia/Reperfusion (I/R) Injury." In Understanding Biology Using Peptides, 457–58. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/978-0-387-26575-9_194.
Full textZoukhri, Driss, Philippe Mauduit, and Bernard Rossignol. "Characterization of Rat Lacrimal Gland Protein Kinase C: Effects of Phorbol Esters and PKC Inhibitors on Histone Kinase Activity and Labelled Protein Discharge." In Advances in Experimental Medicine and Biology, 121–25. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2417-5_21.
Full textde Medeiros, Ana Santos, Grace Kwak, Jordan Vanderhooft, Sam Rivera, Rachel Gottlieb, and Charles S. Hoffman. "Fission Yeast-Based High-Throughput Screens for PKA Pathway Inhibitors and Activators." In Methods in Molecular Biology, 77–91. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-2269-7_6.
Full textWilliams, R. E., B. R. Chakravarthy, and J. P. Durkin. "Minimum structural requirements of myristoylated protein kinase C (PKC) inhibitory peptides: Minimizing the structure of a MARCKS protein derived peptide." In Peptides 1994, 662–63. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-1468-4_303.
Full textBentley, Fiona K., and Julian J. Eaton-Rye. "The Effect of Protein Synthesis Inhibitors on Recovery of Photodamaged Photosystem II in Synechocystis sp. PCC 6803 Lacking PsbM or PsbT." In Photosynthesis. Energy from the Sun, 711–14. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6709-9_158.
Full textEgbring, R., R. Seitz, L. Lerch, G. Fuchs, H. Blanke, M. Wolf, and T. Menges. "Disseminierte intravaskuläre Gerinnung (DIG): Diagnostik mit Hilfe von Proteinase-Inhibitor-Komplexen (PIC), Therapie mit Antithrombin III-Konzentraten und anderen Plasmaderivaten." In 17. Hämophilie-Symposion, 393–402. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-72830-3_93.
Full textLiu, Zhaoping, Andrea Gomez-Donart, Caroline Weldon, Nina Senutovitch, and John O’Rourke. "Developing a Novel Multiplexed Immune Assay Platform to Screen Kinase Modulators of T Cell Activation." In High-Throughput Screening for Drug Discovery [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97304.
Full textYoudim, Moussa, Tamar Amit, Yael Avramovich, Orit Bar-Am, Marta Weinstock, and Merav Yogev-Falach. "PKC and MAP kinase-dependent processing of amyloid precursor protein (APP) by neuroprotective propargylamine cholinesterase inhibitors derived from rasagiline and nonsteroidal anti-inflammatory drugs." In Cholinergic Mechanisms, 353–61. CRC Press, 2004. http://dx.doi.org/10.3109/9780203493878-51.
Full textBello, Martiniano, and Miguel Ángel Vargas Mejía. "Structural Insight of the Anticancer Properties of Doxazosin on Overexpressing EGFR/HER2 Cell Lines." In Breast Cancer [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96628.
Full textConference papers on the topic "PKC inhibitors"
Hopple, Sara, Mark Bushfield, Fiona Murdoch, and D. Euan MacIntyre. "REGULATION OF PLATELET cAMP FORMATION BY PROTEIN KINASE C." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644512.
Full textTakashima, Asami, Zhihong Chen, Brandon English, Robert M. Williams, and Douglas V. Faller. "Abstract B36: Targeting oncogenic RAS with small molecule PKC-delta inhibitors." In Abstracts: AACR Special Conference on RAS Oncogenes: From Biology to Therapy; February 24-27, 2014; Lake Buena Vista, FL. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1557-3125.rasonc14-b36.
Full textShah, Minjel, Christopher Apostolatos, Hercules Apostolatos, and Mildred Acevedo-Duncan. "Abstract 1037: Inverse regulation of p53 by atypical PKC inhibitors in ovarian cancer cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1037.
Full textBreedy, Sloan, Wishrawana S. Ratnayake, Christopher Apostolatos, Avijit Dey, and Mildred Acevedo-Duncan. "Abstract 5216: Atypical PKC inhibitors ICA-1S and ζ-Stat show inhibition of neuroblastoma cell proliferation." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-5216.
Full textShah, Minjel, Christopher Apostolatos, Hercules Apostolatos, and Mildred Acevedo-Duncan. "Abstract POSTER-THER-1428: Effects of atypical PKC inhibitors on ovarian cancer proliferation and RNA levels." In Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.ovcasymp14-poster-ther-1428.
Full textWalshe, K., I. Mackie, M. Gallimore, and S. J. Machin. "PERTURBATION OF THE KALLIKREIN-KININ SYSTEM IN ADULT RESPIRATORY DISTRESS SYNDROME (ARDS)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644336.
Full textBarrett, Rosemary, Ribo Guo, Jing Yuan, Vesselina Cooke, Anthony Vattay, Joshua Korn, Guiqing Liang, et al. "Abstract C149: The PKC inhibitor Sotrastaurin selectively inhibits the growth of GNAQ mutant uveal melanoma." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Oct 19-23, 2013; Boston, MA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1535-7163.targ-13-c149.
Full textSteiner, J., and D. Strickland. "INTERACTION OF PLASMIN WITH ALPHA-2 MACROGLOBULIN (α2 M): EFFECT OF ANTIFIBRINOLYTIC AGENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644382.
Full textBhayankara, Aravind P., Rekha Patel, Hla Win-Piazza, Prajit Pillai, and Mildred E. Acevedo-Duncan. "Abstract LB-437: ICA-1: A novel PKC-i inhibitor inhibits the proliferation of prostate cancer cells." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-437.
Full textJoseph, S. K., S. Krishnamurthi, and V. V. Kakkar. "R59022, A DIACYLGLYCEROL (DG) KINASE INHIBITOR POTENTIATES THROMBIN-INDUCED PLATELET AGGREGATION AND GRANULE RELEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644504.
Full textReports on the topic "PKC inhibitors"
Dickman, Martin B., and Oded Yarden. Role of Phosphorylation in Fungal Spore Germination. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568761.bard.
Full textSaha, Debabrata. Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor. Fort Belvoir, VA: Defense Technical Information Center, September 2014. http://dx.doi.org/10.21236/ada612831.
Full textSaha, Debabrata. Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada584219.
Full textSaha, Debabrata. Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada626324.
Full textBarron, Elizabeth A. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor in the Progress of PC. Fort Belvoir, VA: Defense Technical Information Center, March 2005. http://dx.doi.org/10.21236/ada446889.
Full textWiese, Thomas E., and R. B. Klassen. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC. Fort Belvoir, VA: Defense Technical Information Center, March 2007. http://dx.doi.org/10.21236/ada486576.
Full textWiese, Thomas E., and R. B. Klassen. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada486710.
Full textWiese, Thomas E., and R. B. Klassen. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC. Addendum. Fort Belvoir, VA: Defense Technical Information Center, March 2009. http://dx.doi.org/10.21236/ada512650.
Full textAltstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.
Full textAltstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, October 2006. http://dx.doi.org/10.32747/2006.7587235.bard.
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