Academic literature on the topic 'Pinnatoxins'
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Journal articles on the topic "Pinnatoxins":
Lamas, J. Pablo, Fabiola Arévalo, Ángeles Moroño, Jorge Correa, Susana Muñíz, and Juan Blanco. "Detection and Spatio-Temporal Distribution of Pinnatoxins in Shellfish from the Atlantic and Cantabrian Coasts of Spain." Toxins 11, no. 6 (June 14, 2019): 340. http://dx.doi.org/10.3390/toxins11060340.
Hort, Vincent, Isabel Bastardo-Fernández, and Marina Nicolas. "Exploration of Vulcanodinium rugosum Toxins and their Metabolism Products in Mussels from the Ingril Lagoon Hotspot in France." Marine Drugs 21, no. 8 (July 29, 2023): 429. http://dx.doi.org/10.3390/md21080429.
Finch, Sarah C., D. Tim Harwood, Michael J. Boundy, and Andrew I. Selwood. "A Review of Cyclic Imines in Shellfish: Worldwide Occurrence, Toxicity and Assessment of the Risk to Consumers." Marine Drugs 22, no. 3 (March 11, 2024): 129. http://dx.doi.org/10.3390/md22030129.
Araoz, Romulo, Denis Servent, Jordi Molgó, Bogdan I. Iorga, Carole Fruchart-Gaillard, Evelyne Benoit, Zhenhua Gu, Craig Stivala, and Armen Zakarian. "Total Synthesis of Pinnatoxins A and G and Revision of the Mode of Action of Pinnatoxin A." Journal of the American Chemical Society 133, no. 27 (July 13, 2011): 10499–511. http://dx.doi.org/10.1021/ja201254c.
Tamele, Isidro José, Ilário Timba, Vitor Vasconcelos, and Pedro Reis Costa. "First Report of Pinnatoxins in Bivalve Molluscs from Inhaca Island (South of Mozambique)—South of the Indian Ocean." Journal of Marine Science and Engineering 10, no. 9 (August 31, 2022): 1215. http://dx.doi.org/10.3390/jmse10091215.
Takada, Noboru, Naoyoshi Umemura, Kiyotake Suenaga, Tong Chou, Akito Nagatsu, Takeharu Haino, Kaoru Yamada, and Daisuke Uemura. "Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata." Tetrahedron Letters 42, no. 20 (May 2001): 3491–94. http://dx.doi.org/10.1016/s0040-4039(01)00480-4.
Pelc, Matthew J., and Armen Zakarian. "An Approach to the Imine Ring System of Pinnatoxins." Organic Letters 7, no. 8 (April 2005): 1629–31. http://dx.doi.org/10.1021/ol050321l.
Stivala, Craig E., and Armen Zakarian. "Studies toward the synthesis of pinnatoxins: the spiroimine fragment." Tetrahedron Letters 48, no. 39 (September 2007): 6845–48. http://dx.doi.org/10.1016/j.tetlet.2007.07.182.
Arnich, Nathalie, Eric Abadie, Nicolas Delcourt, Valérie Fessard, Jean-Marc Fremy, Vincent Hort, Emmeline Lagrange, et al. "Health risk assessment related to pinnatoxins in French shellfish." Toxicon 180 (June 2020): 1–10. http://dx.doi.org/10.1016/j.toxicon.2020.03.007.
Rundberget, Thomas, John A. Bunæs Aasen, Andrew I. Selwood, and Christopher O. Miles. "Pinnatoxins and spirolides in Norwegian blue mussels and seawater." Toxicon 58, no. 8 (December 2011): 700–711. http://dx.doi.org/10.1016/j.toxicon.2011.08.008.
Dissertations / Theses on the topic "Pinnatoxins":
Bouquet, Aurélien. "Etude du dinoflagellé benthique toxique Vulcanodinium rugosum dans les lagunes méditerranéennes soumises au changement global : caractérisation toxinique et dynamique in situ, transfert des toxines dans les maillons trophiques supérieurs et risques associés." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2023. http://www.theses.fr/2023UMONG016.
Harmful phytoplankton blooms have growing impacts on ecosystems and human populations. In the context of warming waters and oceans, they are one of the main issues linking environmental, animal and human health. This research focuses on the toxic microalga Vulcanodinium rugosum, which produces pinnatoxins (PnTX) and portimines (Prtn). These toxins accumulate in marine organisms and are frequently detected worldwide, particularly in French Mediterranean lagoons. The objectives were to study the microalga distribution in relationship with environmental conditions in four French Mediterranean lagoons, the contamination by PnTX G and Prtn A of various marine organisms, the ecological impacts and the health risks.At first, we developed a sensitive and specific methodology for detecting Vulcanodinium rugosum cells in marine environments, based on artificial substrates coupled with qPCR (AS-qPCR). The results of our field campaign showed that microalgae and toxins were present in all studied lagoons, and that they could contaminate a wide variety of marine species including bivalve molluscs, fish, gastropods and echinoderms. The spatiotemporal dynamics of microalgae and toxins in mussels were linked to seasonal variations in temperature and other hydrochemical factors. A modeling approach based on environmental parameters enabled us to assess the risks to human populations at different times of the year. We estimated that over 25 % of seafood consumers exceeded the provisional acute benchmark value in summer at Ingril and Vic. We did not observe any impact of mullet juvenile exposure to Vulcanodinium rugosum, but this species could be involved in the expansion of the microalga within the lagoons via transport through the intestinal tract. Finally, the kinetics of contamination and elimination in oysters showed that high concentrations could be linked to long-term exposure, and that PnTX G persisted for a long time in bivalve molluscs’ tissues.This work provided therefore important knowledge on the impacts of Vulcanodinium rugosum on ecosystems and humans. The information and tools developed should be of great interest to environmental and health monitoring managers. This study also led to questions concerning the general expansion of Vulcanodinium rugosum area, other species that could possibly be contaminated, sub-lethal impacts on marine organisms, and the chronic risks to humans inherent in persistent contamination in seafood products. They therefore show the importance of studies focusing on this dinoflagellate and its toxins, particularly in the context of warming waters favoring blooms on a global scale
Abadie, Eric. "Etude de Vulcanodinium rugosum (Dinoflagellé producteur de pinnatoxines) se développant dans la lagune méditerranéennede l’Ingril." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTS188/document.
Harmful and / or toxic phytoplankton blooms impact for a long time marine ecosystems worldwide. These massive developments have an adverse effect on ecosystems and their exploitation. The lagoons of the region Languedoc-Roussillon are affected for decades. In addition to recurring health risks from Dinophysis (DSP toxins) and Alexandrium (PSP toxins), Vulcanodinium rugosum was identified in 2011 in the lagoon Ingril. This new species product pinnatoxins (neurotoxins). Through this thesis work, the biology of this new species (life cycle, growth condition, toxin production), its shellfish contamination capacity and geographic distribution in neighboring lagoons were studied on cultures in the laboratory and via environmental monitoring.The results of this study have demonstrated its thermophilic and euryhaline features (optimum salinity and temperature of 25°C and 40 respectively) and its growth ranges between 20 and 30°C. Its ability to grow on an organic nitrogen source (urea) has been showed in vitro. Its expansion in other lagoons of Languedoc-Roussillon, was confirmed by the contamination of the mussels by the pinnatoxin G. The survival of this organism in the digestive tract of mussels and oysters proves that the transfer of shellfish is potentially a source of contamination of new ecosystems not yet affected by this toxic species.The life cycle of V. rugosum has not been fully described because the resistance cyst has not been formally identified. Temporary cysts appear as very important stages to be considered because of their ability to divide and their strong presence on macrophytes. These temporary forms of resistance may be a significant source of contamination of shellfish in the lagoon of the Ingril even when the vegetative cells of V. rugosum are weakly present in the water column. Because of the low densities of V. rugosum in situ and the difficulty of its identification on morphological criteria, the monitoring within the REPHY protocol remains difficult. Thus the use of passive sampling systems (Spatt) made with resins which adsorb toxins dissolved in water would make possible the early detection of toxins associated with these emerging benthic species. This study highlights the growth of an emerging thermophilic species that might with others and thanks to climate change provide important health and economic problems in vulnerable lagoon ecosystems of the Mediterranean
Pelc, Matthew J. Zakarian Armen. "Tandem Claisen Mislow-Evans rearrangement in formation of the A-G ring system in Pinnatoxin A." 2006. http://etd.lib.fsu.edu/theses/available/etd-06192006-175353.
Advisor: Armen Zakarian, Florida State University, College of Arts and Sciences, Dept. of Chemistry. Title and description from dissertation home page (viewed Sept. 19, 2006). Document formatted into pages; contains xiv, 120 pages. Includes bibliographical references.
Book chapters on the topic "Pinnatoxins":
Mabe, Phillip, and Armen Zakarian. "Chemistry of pinnatoxins." In Phycotoxins, 49–68. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118500354.ch3.
Hellyer, Shane Dennis. "Marine-derived nicotinic receptor antagonist toxins: Pinnatoxins and alpha conotoxins." In Marine Neurotoxins, 105–91. Elsevier, 2021. http://dx.doi.org/10.1016/bs.ant.2021.03.004.
"Toxicology of Cyclic Imines: Gymnodimine, Spirolides, Pinnatoxins, Pteriatoxins, Prorocentrolide, Spiro-Prorocentrimine, and Symbioimines." In Seafood and Freshwater Toxins, 599–612. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541-45.
Taber, Douglass. "The Zakarian Synthesis of ( + )-Pinnatoxin A." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0097.
Carter, R. G., and D. L. Kuiper. "Base-Catalyzed Michael Addition toward Pinnatoxin." In Stereoselective Reactions of Carbonyl and Imino Groups, 1. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-202-00509.
Carter, R. G., and D. L. Kuiper. "Use of Neighboring-Group Effects in Bisspiroketal Formation toward Pinnatoxin." In Stereoselective Reactions of Carbonyl and Imino Groups, 1. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-202-00508.