Relevant bibliographies by topics / Pimonidazole

Academic literature on the topic 'Pimonidazole'

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Published: 4 June 2021
Last updated: 21 February 2023

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Journal articles on the topic "Pimonidazole"

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Ullsten, Sara, Joey Lau, and Per-Ola Carlsson. "Decreased β-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets." Journal of the Endocrine Society 3, no. 8 (June 17, 2019): 1608–16. http://dx.doi.org/10.1210/js.2019-00101.

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Abstract Low-oxygenated and dormant islets with a capacity to become activated when needed may play a crucial role in the complex machinery behind glucose homeostasis. We hypothesized that low-oxygenated islets, when not functionally challenged, do not rapidly cycle between activation and inactivation but are a stable population that remain low-oxygenated. As this was confirmed, we aimed to characterize these islets with regard to cell composition, vascular density, and endocrine cell proliferation. The 2-nitroimidazole low-oxygenation marker pimonidazole was administered as a single or repeated dose to Wistar Furth rats. The stability of oxygen status of islets was evaluated by immunohistochemistry as the number of islets with incorporated pimonidazole adducts after one or repeated pimonidazole injections. Adjacent sections were evaluated for islet cell composition, vascular density, and endocrine cell proliferation. Single and repeated pimonidazole injections over an 8-hour period yielded accumulation of pimonidazole adducts in the same islets. An average of 30% of all islets was in all cases positively stained for pimonidazole adducts. These islets showed a similar endocrine cell composition as other islets but had lower vascular density and β-cell proliferation. In conclusion, low-oxygenated islets were found to be a stable subpopulation of islets for at least 8 hours. Although they have previously been observed to be less functionally active, their islet cell composition was similar to that of other islets. Consistent with their lower oxygenation, they had fewer blood vessels than other islets. Notably, β-cell regeneration preferentially occurred in better-oxygenated islets.
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Doege, Kathrin, Sandra Heine, Inga Jensen, Wolfgang Jelkmann, and Eric Metzen. "Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact." Blood 106, no. 7 (October 1, 2005): 2311–17. http://dx.doi.org/10.1182/blood-2005-03-1138.

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Abstract The transcription factor hypoxia-inducible factor-1 (HIF-1) is critical for erythropoietin and other factors involved in the adaptation of the organism to hypoxic stress. Conflicting results have been published regarding the role of the mitochondrial electron transport chain (ETC) in the regulation of HIF-1α. We assessed cellular hypoxia by pimonidazole staining and blotting of the O2-labile HIF-1 α-subunit in human osteosarcoma cell cultures (U2OS and 143B). In conventional, gas-impermeable cell culture dishes, ETC inhibitors had no effect on pimonidazole staining or HIF-1α abundance in a 20% O2 atmosphere; both parameters were undetectable. Pimonidazole staining and HIF activity were substantial in 0.1% O2 irrespective of ETC inhibition. At an intermediate oxygen concentration (3% O2) pimonidazole staining and HIF-α expression were detectable but strongly reduced after ETC inhibition in conventional cell cultures. All effects of ETC inhibition on HIF-1α regulation were eliminated in gas-permeable dishes. As shown in a 143B subclone deficient in mitochondrial DNA (206ρ0), genetic inactivation of the ETC led to similar responses with respect to HIF-1α regulation as ETC inhibitors. Our data demonstrate that reduction of oxygen consumption reduces the O2 gradient in conventional cell cultures, causing elevation of the cellular O2 concentration, which leads to degradation of HIF-α.
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Arteel, G. E., J. A. Raleigh, B. U. Bradford, and R. G. Thurman. "Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 3 (September 1, 1996): G494—G500. http://dx.doi.org/10.1152/ajpgi.1996.271.3.g494.

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Previous studies using liver slices and isolated perfused rat liver have suggested that ethanol causes hypoxia by increasing oxygen consumption. However, ethanol also increases blood flow to the liver, a phenomenon that may counteract the effects of hypermetabolism by increasing oxygen delivery. Thus whether ethanol causes hypoxia in vivo remains unclear. To clarify this important point, female Sprague-Dawley rats (100-125 g) simultaneously received pimonidazole (120 mg/kg ip), a 2-nitroimidazole hypoxia marker, and one large dose of ethanol (5 g/kg ig), which increase hepatic oxygen uptake dramatically and elevate ethanol metabolism (swift increase in alcohol metabolism) in 2-3 h. After 2 h, ethanol significantly increased the accumulation of bound pimonidazole in pericentral regions of the liver lobule. Treatment of animals with the Kupffer cell-specific toxicant, GdCl3 (10 mg/kg iv, 24 h before experiment), blocked ethanol-induced increases in pimonidazole binding. It is concluded that one large dose of ethanol causes pericentral hypoxia in rat liver tissue in vivo and that Kupffer cells are involved.
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Ow, Connie P. C., Md Mahbub Ullah, Jennifer P. Ngo, Adheeshee Sayakkarage, and Roger G. Evans. "Detection of cellular hypoxia by pimonidazole adduct immunohistochemistry in kidney disease: methodological pitfalls and their solution." American Journal of Physiology-Renal Physiology 317, no. 2 (August 1, 2019): F322—F332. http://dx.doi.org/10.1152/ajprenal.00219.2019.

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Pimonidazole adduct immunohistochemistry is one of the few available methods for assessing renal tissue hypoxia at the cellular level. It appears to be prone to artifactual false positive staining under some circumstances. Here, we assessed the nature of this false positive staining and, having determined how to avoid it, reexamined the nature of cellular hypoxia in rat models of kidney disease. When a mouse-derived anti-pimonidazole primary antibody was used, two types of staining were observed. First, there was diffuse staining of the cytoplasm of tubular epithelial cells, which was largely absent when the primary antibody was omitted from the incubation protocol or in tissues known not to contain pimonidazole adducts. Second, there was staining of the apical membranes of tubular epithelial cells, debris within the lumen of renal tubules, including tubular casts, and the interstitium; this latter staining was present even when the primary antibody was omitted from the incubation protocol. Such false positive staining was particularly prominent in acutely injured kidneys. It could not be avoided by preincubation of sections with a mouse IgG blocking reagent. Furthermore, preadsorption of the secondary antibody against rat Ig abolished all staining; however, when a rabbit-derived polyclonal anti-pimonidazole primary antibody was used, the false positive staining was largely avoided. Using this method, we confirmed the presence of hypoxia, localized mainly to the tubular epithelium, in the acute phase of severe renal ischemia-reperfusion injury, adenine-induced chronic kidney disease, and polycystic kidney disease. We conclude that this new method provides improved detection of renal cellular hypoxia.
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Gabellieri, Cristina, Thomas R. Eykyn, and Martin O. Leach. "Conformational exchange in pimonidazole—a hypoxia marker." Magnetic Resonance in Chemistry 45, no. 8 (2007): 621–23. http://dx.doi.org/10.1002/mrc.2024.

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Via, Laura E., P. Ling Lin, Sonja M. Ray, Jose Carrillo, Shannon Sedberry Allen, Seok Yong Eum, Kimberly Taylor, et al. "Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates." Infection and Immunity 76, no. 6 (March 17, 2008): 2333–40. http://dx.doi.org/10.1128/iai.01515-07.

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ABSTRACT Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue. We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit, and nonhuman primate. Following infusion of pimonidazole into animals with established infections, lung tissues from the guinea pig, rabbit, and nonhuman primate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous regions of pulmonary granulomas by immunohistochemical staining. This labeling could be substantially reduced by housing the animal under an atmosphere of 95% O2. Direct measurement of tissue oxygen partial pressure by surgical insertion of a fiber optic oxygen probe into granulomas in the lungs of living infected rabbits demonstrated that even small (3-mm) pulmonary lesions were severely hypoxic (1.6 ± 0.7 mm Hg). Finally, metronidazole, which has potent bactericidal activity in vitro only under low-oxygen culture conditions, was highly effective at reducing total-lung bacterial burdens in infected rabbits. Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis.
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Lin, Yu, Ying-Na Bao, Cong-Xiu Huang, Ji-Hong Zhang, Zhi-Long Yu, Ye Tian, Xiang-Cheng Wang, and Yi-Tong Cui. "The Effect of Carbogen Breathing on 18F-FDG Uptake in Non-Small-Cell Lung Cancer." BioMed Research International 2019 (November 22, 2019): 1–6. http://dx.doi.org/10.1155/2019/2920169.

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It has been reported that 18F-FDG uptake is higher in hypoxic cancer cells than in well-oxygenated cells. We demonstrated that 18F-FDG uptake in lung cancer would be affected by high concentration oxygen breathing. Methods. Overnight fasted non-small-cell lung cancer A549 subcutaneous (s.c.) xenografts bearing mice (n = 10) underwent 18F-FDG micro-PET scans, animals breathed room air on day 1, and same animals breathed carbogen (95% O2 + 5% CO2) on the subsequent day. In separated studies, autoradiography and immunohistochemical staining visualization of frozen section of A549 s.c. tumors were applied, and to compare between carbogen-breathing mice and those with air breathing, a combination of 18F-FDG and hypoxia marker pimonidazole was injected 1 h before animal sacrifice, and 18F-FDG accumulation was compared with pimonidazole binding and glucose transporter 1 (GLUT-1) expression. Results. PET studies revealed that tumor 18F-FDG uptake was significantly decreased in carbogen-breathing mice than those with air breathing (P<0.05). Ex vivo studies confirmed that carbogen breathing significantly decreased hypoxic fraction detected by pimonidazole staining, referring to GLUT-1 expression, and significantly decreased 18F-FDG accumulation in tumors. Conclusions. High concentration of O2 breathing during 18F-FDG uptake phase significantly decreases 18F-FDG uptake in non-small-cell lung cancer A549 xenografts growing in mice.
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Busk, Morten, Steen Jakobsen, Michael R. Horsman, Lise S. Mortensen, Ane B. Iversen, Jens Overgaard, Marianne Nordsmark, Xiaosheng Ji, David Y. Lee, and James R. Raleigh. "PET imaging of tumor hypoxia using18F-labeled pimonidazole." Acta Oncologica 52, no. 7 (August 21, 2013): 1300–1307. http://dx.doi.org/10.3109/0284186x.2013.815797.

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Workman, Paul. "Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: A possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination." International Journal of Radiation Oncology*Biology*Physics 16, no. 4 (April 1989): 1011–14. http://dx.doi.org/10.1016/0360-3016(89)90905-x.

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Down, Julian D., Kalindi Parmar, James Clyne, Peter M. Mauch, and Robert Sackstein. "Defining the Bone Marrow Stem Cell Niche According to a Hoechst Dye Diffusion Gradient and Hypoxia." Blood 104, no. 11 (November 16, 2004): 666. http://dx.doi.org/10.1182/blood.v104.11.666.666.

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Abstract The spatial organization of hematopoietic cell subsets of differing proliferative potential within the bone marrow microenvironment has come under increasing interest. In particular, it has been suggested that hematopoietic stem cells (HSCs) normally reside in a regulatory niche situated at the endosteal bone surface and in close proximity to osteoblasts. In the present study we have investigated how different hematopoietic cell subsets are distributed along a Hoechst dye perfusion gradient that may reflect the distance from marrow blood vessels and the level of oxygenation. C57BL/6J mice were intravenously injected with two doses of Hoechst 33342 at 10 and 5 min before marrow cell harvesting, a period that we determined was insufficient for active dye exclusion in vitro. Flow cytometric analysis revealed a wide distribution of Hoechst staining over 3 logs fluorescence intensity. The cells were then sorted from 6 different regions of the Hoechst gradient and evaluated for short- and long-term in vitro repopulating cells in the cobblestone area-forming cell (CAFC) assay. The primitive CAFC subset appearing at day 28 in culture was shown to be progressively enriched with decreasing Hoechst fluorescence while the short-term repopulating day 7 CAFC subset frequencies was the highest at an intermediate level of Hoechst staining. We further investigated whether primitive HSCs exist in a very low oxygen tension by administering the reductive 2-nitroimidazole compound pimonidazole in vivo and performed flow cytometric analysis on sorted primitive HSCs residing in high Hoechst dye effluxing side population (SP). In comparison to whole bone marrow or non-SP cells, the SP fraction showed increased intracellular staining with an anti-pimonidazole antibody that recognizes pimonidazole adducts formed only under hypoxic conditions (less than pO2 of 10 mm Hg). Comparison with thymocytes that are already known to be hypoxic in vivo (Hale et al. Am J Physiol Heart Circ Physiol282: H1467–H1477, 2002) showed both low Hoechst dye perfusion and positive anti-pimonidazole antibody staining. These results represent the first direct evidence that the hematopoietic cell hierarchy is spatially organized in relation to blood vessels and that the stem cell niche exists at the lowest end of an oxygen gradient. These findings have important implications in hematopoiesis and stem cell lodgement, and suggest that the location of hematopoietic stem cells in situ may render them more resistant to oxygen-dependent mutagenic and cytotoxic agents.
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Dissertations / Theses on the topic "Pimonidazole"

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El, Gamoussi Rachida. "Lien entre le contenu intracellulaire en mélaninela radiosensibilisation et la concentration intracellulaire de pimonidazole dans des cellules mélaniques humaines." Paris 12, 1992. http://www.theses.fr/1992PA120038.

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La radiosensibilisation tumorale par le pimonidazole (pimo) (2-nitroimidazole) n'est pas toujours correlee a la concentration intratumorale surtout dans les tumeurs melaniques. Le but de cette etude est de determiner quel(s) est (sont) le(s) facteur(s) responsable(s) de cette absence de lien entre les donnees pharmacocinetiques et la radiosensiblite par le pimo dans les melanomes. Une etude comparative a ete realisee avec l'etanidazole (eta) dont la radiosensibilisation est correlee a la concentration intratumorale. In vitro, nous avons utilise 2 lignees melaniques humaines na11+ et na11. Na11 est une sous lignee amelanique qui derive de la lignee melanique na11+; les cellules en phase de plateau et les tumeurs sont tres pigmentees pour la lignee na11+ alors qu'elles ne sont pas pigmentees pour la lignee na11. La concentration intracellulaire d'eta ne depend ni des conditions de proliferation ni du contenu intracellulaire en melanine. La concentration intracellulaire de pimo augmente en fonction du contenu intracellulaire en melanine (qui est lie a la cinetique de proliferation). La radiosensibilisation par l'eta est correlee a la concentration intracellulaire. Au contraire, avec le pimo la radiosensibilisation des cellules pigmentees en phase de plateau n'est pas correle a la concentration intracellulaire et est reduite par rapport a celle obtenue pour les cellules en croissance exponentielle. In vivo, l'accumulation intratumorale de pimo est tres elevee dans les zones necrotiques contenant des noyaux picnotiques, ou la pigmentation est aussi tres elevee. L'absence de la radiosensibilisation des melanomes par le pimo est en grande partie liee au fait que le compose est concentre dans les zones des cellules non viables de la tumeur, ou la concentration de la melanine est tres elevee
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Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life
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Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Doctor of Philosophy(PhD)
Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life
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"Intra- and Inter-Modality Registration for Validation of MRI based Hypoxia Imaging." Master's thesis, 2018. http://hdl.handle.net/2286/R.I.50603.

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abstract: Hypoxia is a pathophysiological condition which results from lack of oxygen supply in tumors. The assessment of tumor hypoxia and its response to therapies can provide guidelines for optimization and personalization of therapeutic protocols for better treatment. Previous research has shown the difficulty in measuring hypoxia anatomically due to its heterogenous nature. This makes the study of hypoxia through various imaging modalities and mapping techniques crucial. The potential of hypoxia targeting T1 contrast agent GdDO3NI in generating hypoxia maps has been studied earlier. In this work, the similarities between hypoxia maps generated by MRI using GdDO3NI and pimonidazole based immunohistochemistry (IHC) in non-small cell lung carcinoma bearing mice have been studied. Six NCI-H1975 tumor-bearing mice were studied. All animal studies were approved by Arizona State University’s Institute of Animal Care and Use Committee (IACUC). Post co-injection of GdDO3NI and pimonidazole, T1 weighted 3D gradient echo MR images were acquired. For ex-vivo analysis of hypoxia, 30 μm thick tumor sections were obtained for each harvested tumor and were stained for pimonidazole and counter-stained with DAPI for nuclear staining. Pimonidazole (PIMO) is clinically used as a “gold standard” hypoxia marker. The key process involved stacking and iterative registration based on quality metric SSIM (Structural Similarity) Index of DAPI stained images of 5 consecutive tumor sections to produce a 3D volume stack of 150 μm thickness. Information from the 3D volume is combined to produce one final slide by averaging. The same registration transform was applied to stack the pimonidazole images which were previously thresholded to highlight hypoxic regions. The registered IHC stack was then co-registered with a single thresholded T1 weighted gradient echo MRI slice of the same location (~156 μm thick) using an elastic B-splines transform. The same transform was applied to achieve the co-registration of pimonidazole and MR percentage enhancement image. Image similarity index after the co-registration was found to be greater than 0.5 for 5 of the animals suggesting good correlation. R2 values were calculated for both hypoxic regions as well as tumor boundaries. All the tumors showed a high boundary correlation value of R2 greater than 0.8. Half of the animals showed high R2 values greater than 0.5 for hypoxic fractions. The RMSE values for the co-registration of all the animals were found to be low further suggesting better correspondence and validating the MR based hypoxia imaging.
Dissertation/Thesis
Masters Thesis Biomedical Engineering 2018
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Book chapters on the topic "Pimonidazole"

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Rosenberger, Christian, Seymour Rosen, Alexander Paliege, and Samuel N. Heyman. "Pimonidazole Adduct Immunohistochemistry in the Rat Kidney: Detection of Tissue Hypoxia." In Methods in Molecular Biology, 161–74. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-352-3_12.

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Terada, Nobuo, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno. "Application of “In Vivo Cryotechnique” to Immunohistochemical Detection of Hypoxia in Mouse Liver Tissues Treated with Pimonidazole." In In Vivo Cryotechnique in Biomedical Research and Application for Bioimaging of Living Animal Organs, 29–32. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55723-4_7.

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Labiano, Sara, Irantzu Serrano-Mendioroz, and María Esperanza Rodriguez-Ruiz. "Assessment of hypoxia by pimonidazole staining following radiotherapy." In Methods in Cell Biology. Elsevier, 2022. http://dx.doi.org/10.1016/bs.mcb.2022.07.002.

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Dische, S. "RADIOTHERAPY, CARCINOMA OF CERVIX AND THE RADIOSENSITIZER Ro 03-8799 (PIMONIDAZOLE)." In Congress Proceedings, 584–89. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-12-168562-1.50105-1.

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Wismann, G., G. Hampel, W. Wagner, K. D. Richter, and A. Härle. "Analysis of the Efficacy and Toxicity of the Radiosensitizers Pimonidazole and Misonidazole on a Xenotransplanted Osteosarcoma Irradiated with Single 60Co-Doses." In Immunodeficient Mice in Oncology, 577–80. S. Karger AG, 1992. http://dx.doi.org/10.1159/000421336.

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