Relevant bibliographies by topics / Pigment epithelium-derived factor

Academic literature on the topic 'Pigment epithelium-derived factor'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Pigment epithelium-derived factor"

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Bell, Christopher. "Pigment Epithelium-Derived Factor." Exercise and Sport Sciences Reviews 39, no. 4 (October 2011): 187–90. http://dx.doi.org/10.1097/jes.0b013e31822673f0.

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Shao, Hanshuang, Iris Schvartz, and Shmuel Shaltiel. "Secretion of pigment epithelium-derived factor." European Journal of Biochemistry 270, no. 5 (September 10, 2003): 822–31. http://dx.doi.org/10.1046/j.1432-1033.2003.03374.x.

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Rogers, Morgan E., Iris D. Navarro, Kristin M. Perkumas, Shannon M. Niere, R. Rand Allingham, Craig E. Crosson, and W. Daniel Stamer. "Pigment Epithelium-Derived Factor Decreases Outflow Facility." Investigative Opthalmology & Visual Science 54, no. 10 (October 11, 2013): 6655. http://dx.doi.org/10.1167/iovs.13-12766.

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Becerra, S. Patricia, L. Alberto Perez-Mediavilla, John E. Weldon, Silvia Locatelli-Hoops, Preenie Senanayake, Luigi Notari, Vicente Notario, and Joe G. Hollyfield. "Pigment Epithelium-derived Factor Binds to Hyaluronan." Journal of Biological Chemistry 283, no. 48 (September 19, 2008): 33310–20. http://dx.doi.org/10.1074/jbc.m801287200.

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Ho, Tsung-Chuan, Yuh-Cheng Yang, Huey-Chuan Cheng, Ai-Ching Wu, Show-Li Chen, and Yeou-Ping Tsao. "Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction." Biochemical and Biophysical Research Communications 342, no. 2 (April 2006): 372–78. http://dx.doi.org/10.1016/j.bbrc.2006.01.164.

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Fernandez-Garcia, N. I., O. V. Volpert, and B. Jimenez. "Pigment epithelium-derived factor as a multifunctional antitumor factor." Journal of Molecular Medicine 85, no. 1 (November 15, 2006): 15–22. http://dx.doi.org/10.1007/s00109-006-0111-z.

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Yamagishi, Sho-ichi, and Takanori Matsui. "Pigment Epithelium-derived Factor (PEDF) and Cardiometabolic Disorders." Current Pharmaceutical Design 20, no. 14 (May 31, 2014): 2377–86. http://dx.doi.org/10.2174/13816128113199990473.

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Ek, Eugene T. H., Crispin R. Dass, and Peter F. M. Choong. "Pigment epithelium-derived factor: a multimodal tumor inhibitor." Molecular Cancer Therapeutics 5, no. 7 (July 2006): 1641–46. http://dx.doi.org/10.1158/1535-7163.mct-06-0107.

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Cosgrove, Gregory P., Kevin K. Brown, William P. Schiemann, Amanda E. Serls, Jane E. Parr, Mark W. Geraci, Marvin I. Schwarz, Carlyne D. Cool, and G. Scott Worthen. "Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis." American Journal of Respiratory and Critical Care Medicine 170, no. 3 (August 2004): 242–51. http://dx.doi.org/10.1164/rccm.200308-1151oc.

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Patricia Becerra, S. "Focus on Molecules: Pigment epithelium-derived factor (PEDF)." Experimental Eye Research 82, no. 5 (May 2006): 739–40. http://dx.doi.org/10.1016/j.exer.2005.10.016.

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Dissertations / Theses on the topic "Pigment epithelium-derived factor"

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Zhang, Yadan. "Mechanism(s) by which pigment epithelium-derived factor regulate angiogenesis." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54652/.

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Pigment Epithelium-derived Factor (PEDF), a natural protein possessing both neuroprotective and anti-angiogenic properties, is a very unique and attractive candidate as a therapeutic agent in the management of pathological neovascular diseases, such as tumours, age-related macular degeneration (AMD) and diabetic retinopathy. While it is well-known that PEDF can exert powerful effects on various tissues and cells, the underlying mechanism of PEDF's action is not well understood. This study investigated the relationship between vascular endothelial growth factor (VEGF)/PEDF and VEGFR-1 /VEGFR-2 by exploring Presenilin-l (PS-l) dependent regulated intramembrane proteolysis (RIP). Work on this non-classical pathway was initiated by Cai et al., (2006) using in vitro models of bovine retinal microvascular endothelial cells (BRMECs). Current study used BRMECs and human retinal pigment epithelial (HRPE) cells. In this study, BRMECs and HRPE cells were isolated and cultured. BRMECs were used as an angiogenic cell type while HRPE cells were used as an angiogenic regulator cell type. The characteristics of endothelial and epithelial cells and the localisation of VEGFR-1, VEGFR-2 and PS in BRMECs and HRPE cells were determined using immunocytochemistry techniques. The effects of VEGF and PEDF on VEGFR-1, VEGFR-2 and PS were assessed using immunocytochemistry and Western blotting, y-secretase activity in BRMECs and HRPE cells treated with various growth factors were analysed using a y-secretase activity kit. The role of VEGF on the production of PEDF and the expression of VEGFR-1, VEGFR-2 and PS in HRPE cells was investigated at both the transcriptional and translational levels. The techniques, VEGF-small interfering ribonucleic acid (VEGF-siRNA), reverse transcription-polymerase chain reaction (RT-PCR), Western blotting and Enzyme-linked immunosorbent assay (ELISA) were used for the investigation. Results obtained from the project showed that PEDF had a regulatory role in the counterbalance of VEGFR-1 and VEGFR-2 expression in cultured BRMECs. PEDF upregulated y-secretase activity and PS-1 expression in BRMECs while VEGF acted as an antagonist of the effect of PEDF. In contrast, in HRPE cells, VEGF upregulated y-secretase activity and PEDF acted as an antagonist of the effect of VEGF. VEGF-siRNA induced a reduction of PEDF at both transcriptional and protein levels and a reduction of VEGFR-1 at the protein level. The effects of VEGF and PEDF on VEGFR-1 and VEGFR-2 may be cell type dependent. This study strengthens the view that PEDF can exert different regulatory effects on the same molecule (s) in different cell types. PEDF acts either antagonistically to VEGF or synergistically dependent upon the target molecule. Deciphering the cellular and molecular mechanisms underlying these interactions will not only contribute to our understanding of PEDF's action but also provide the foundation to maximise the therapeutic potential of this protein.
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Höhne, Katja [Verfasser]. "Pigment Epithelium-derived Factor in Augen von Aderhautmelanom-Patienten / Katja Höhne." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1027498183/34.

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Harries, Rhiannon. "The clinical relevance of pigment epithelium-derived factor (PEDF) in wound healing and colorectal cancer." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/105300/.

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There are similarities between tissue repair and cancer development. Epithelial tumours promote the formation of the stroma by activation of the wound healing process, but unlike healing wounds the process is not self-limiting. Pigment epithelium derived factor(PEDF)is a secreted glycoprotein that has been shown to exhibit multiple biological properties including anti-angiogenesis, anti-tumorigenesis and immune-modulation. Previous studies demonstrated that PEDF expression is downregulated as prognostic factors worsen in a range of cancers and chronic inflammatory conditions and treatment with recombinant PEDF has showed some benefit in cellular functional models. However, there has been little evidence to date to assess the role of PEDF in colorectal cancer and wound healing. The aims of this study were to elucidate more detailed regulatory mechanisms of PEDF in wound healing, and tumour angiogenesis in colorectal cancer and provide evidence to develop PEDF or its fragments as therapeutics for wound healing or colorectal cancer treatment. This study found that PEDF expression was down regulated in colorectal cancer cell lines and tissue and that treatment with recombinant PEDF resulted in significant decreases in the rate of colorectal cancer cellular migration and invasion and an increase in cellular adhesion in some colorectal cancer cell lines examined, suggesting a promising role of the treatment of PEDF in the prevention of colorectal cancer metastatic spread. Within wound healing, our results indicated that PEDF expression was high amongst dermal fibroblasts but less so in keratinocytes and endothelial cell lines, suggesting that fibroblasts are responsible for secretion of PEDF in response to inflammation. In cellular functional models, recombinant PEDF treatment significantly increased the migration of keratinocytes, suggesting a possible role as a chronic wound treatment. Further studies are warranted to assess the role of PEDF in a range of colorectal cancer subsets, other wound healing cells and animal models to identify a suitable delivery vector.
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Nakata, Isao. "Genetic Variants in Pigment Epithelium-Derived Factor Influence Response of Polypoidal Choroidal Vasculopathy to Photodynamic Therapy." Kyoto University, 2013. http://hdl.handle.net/2433/174798.

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Kutz, André [Verfasser]. "Funktionelle Untersuchung des Pigment epithelium derived factor (PEDF) in ß-Zellen [Beta-Zellen] des endokrinen Pankreas / André Kutz." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023709325/34.

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Halin, Sofia. "Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor." Doctoral thesis, Umeå universitet, Patologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30300.

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BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed.  Prostate cancers are composed of tumor epithelial cells as well as many non-epithelial cells such as cancer associated fibroblasts, blood vessels and inflammatory cells.  Many components of the tumor microenvironment such as tumor associated macrophages and angiogenesis have been shown to stimulate tumor progression. This thesis aims to explore mechanisms by which the local environment influences prostate tumor growth and how such mechanisms could be targeted for treatment. MATERIALS AND METHODS: We have used animal models of prostate cancer, in vitro cell culture systems and clinical materials from untreated prostate cancer patients with long follow up. Experiments were evaluated with stereological techniques, immunohistochemistry, western blotting, quantitative real-time PCR, PCR arrays and laser micro dissection. RESULTS: We found that the presence of a tumor induces adaptive changes in the surrounding non-malignant prostate tissue, and that androgen receptor negative prostate tumor cells respond to castration treatment with temporarily reduced growth when surrounded by normal castration-responsive prostate tissue. Further, we show that macrophages are important for prostate tumor growth and angiogenesis in the tumor and in the surrounding non-malignant tissue. In addition, the angiogenesis inhibitor Pigment epithelium-derived factor (PEDF) was found  to be down-regulated in metastatic rat and human prostate tumors. Over-expression of PEDF inhibited experimental prostate tumor growth, angiogenesis and metastatic growth and stimulated macrophage tumor infiltration and lymphangiogenesis. PEDF was found to be down-regulated by the prostate microenvironment and tumor necrosis factor (TNF) α. CONCLUSIONS: Our studies indicate that not only the nearby tumor microenvironment but also the surrounding non-malignant prostate tissue are important for prostate tumor growth. Both the tumor and the surrounding non-malignant prostate were characterized by increased angiogenesis and inflammatory cell infiltration. Targeting the surrounding prostate tissue with castration, targeting tumor associated macrophages, or targeting the vasculature directly using inhibitors like PEDF were all shown to repress prostate tumor growth and could prove beneficial for patients with advanced prostate cancer.
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Bernard-Jaoul, Adrien. "Identification et caractérisation de l'intéraction du Pigment Epithelium-Derived Factor (PEDF) avec le récepteur de la laminine 37LRP/67LR." Paris 6, 2009. http://www.theses.fr/2009PA066726.

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Sun, Jianan. "Protective Effects of Human iPS-Derived Retinal Pigmented Epithelial Cells in Comparison with Human Mesenchymal Stromal Cells and Human Neural Stem Cells on the Degenerating Retina in rd1 Mice." Kyoto University, 2016. http://hdl.handle.net/2433/215387.

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Terzi, Menderes Yusuf [Verfasser]. "The role and influence of pigment epithelium-derived factor (PEDF) on peripheral nerve tumor, brain trauma and stroke / Menderes Yusuf Terzi." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071088068/34.

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Pillai, Deepu [Verfasser], and Felix [Akademischer Betreuer] Schlachetzki. "Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats - a magnetic resonance imaging study at 3 tesla / Deepu Pillai. Betreuer: Felix Schlachetzki." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1037311396/34.

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Book chapters on the topic "Pigment epithelium-derived factor"

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Polato, Federica, and S. Patricia Becerra. "Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo." In Retinal Degenerative Diseases, 699–706. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17121-0_93.

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Nadal-Nicolas, Francisco M., and S. Patricia Becerra. "Pigment Epithelium-derived Factor Protects Retinal Pigment Epithelial Cells Against Cytotoxicity “In Vitro”." In Retinal Degenerative Diseases, 457–64. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75402-4_56.

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Cao, Wei, Joyce Tombran-Tink, Rajesh Elias, Steven Sezate, and James F. McGinnis. "Role of Pigment Epithelium-Derived Factor (PEDF) in Photoreceptor Cell Protection." In New Insights Into Retinal Degenerative Diseases, 119–26. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1355-1_14.

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Subramanian, Preeti, Matthew Rapp, and S. Patricia Becerra. "Identification of Pigment Epithelium-Derived Factor Receptor (PEDF-R) Antibody Epitopes." In Retinal Degenerative Diseases, 799–805. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0631-0_102.

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Ogata, Nahoko, and Joyce Tombran-Tink. "Balance between Pigment Epithelium-Derived Factor and Vascular Endothelial Growth Factor in Diabetic Retinopathy." In Experimental Approaches to Diabetic Retinopathy, 124–41. Basel: KARGER, 2009. http://dx.doi.org/10.1159/000262666.

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Rapp, Matthew, Grace Woo, Muayyad R. Al-Ubaidi, S. Patricia Becerra, and Preeti Subramanian. "Pigment Epithelium-Derived Factor Protects Cone Photoreceptor-Derived 661W Cells from Light Damage Through Akt Activation." In Retinal Degenerative Diseases, 813–20. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-3209-8_102.

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Aymerich, Maria S., Alfredo Martinez, and S. Patricia Becerra. "Characterization and Localization of Pigment Epithelium-Derived Factor Binding Sites in the Bovine Retina." In New Insights Into Retinal Degenerative Diseases, 127–33. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1355-1_15.

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Kothary, Piyush C., Rhonda Lahiri, Lynn Kee, Nitin Sharma, Eugene Chun, Angela Kuznia, and Monte A. Del Monte. "Pigment Epithelium-Derived Growth Factor Inhibits Fetal Bovine Serum Stimulated Vascular Endothelial Growth Factor Synthesis in Cultured Human Retinal Pigment Epithelial Cells." In Retinal Degenerative Diseases, 513–18. Boston, MA: Springer US, 2006. http://dx.doi.org/10.1007/0-387-32442-9_71.

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Subramanian, Preeti, Patricia M. Notario, and S. Patricia Becerra. "Pigment Epithelium-derived Factor Receptor (PEDF-R): A Plasma Membrane-linked Phospholipase with PEDF Binding Affinity." In Retinal Degenerative Diseases, 29–37. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1399-9_4.

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Chung, Chuhan, Jennifer A. Doll, Veronica M. Stellmach, John Gonzales, Sailesh Surapureddi, Mona Cornwell, Janardan K. Reddy, and Susan E. Crawford. "Pigment Epithelium-derived Factor is an Angiogenesis and Lipid Regulator that Activates Peroxisome Proliferator-activated Receptor α." In Hormonal Carcinogenesis V, 591–97. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-69080-3_61.

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Conference papers on the topic "Pigment epithelium-derived factor"

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Li, Xiaoou, Xinyu Liu, Ting Yang, Tao Wang, and Fu Q. Wen. "Up Regulation Of Pigment Epithelium-Derived Factor In Cigarette Smoke-Induced Airway Inflammation." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1317.

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Fitzgerald, Daniel P., Diane Palmieri, Yongzhen Qian, Monika Deshpande, Pretti Subramanian, Christian Graves, Sean Davis, et al. "Abstract 2846: Pigment epithelium-derived factor (PEDF) functions as a brain metastasis suppressor of breast cancer." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2846.

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Dai, Luqi, Tao Wang, Lian Liu, Jun Chen, and Fuqiang Wen. "Late Breaking Abstract - Pigment epithelium-derived factor regulates cigarette-induced abnormal apoptosis of alveolar type II cells." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2029.

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Maya, Joanna, Tyler Robin, Susan Crawford, Paul M. Campbell, Channing J. Der, Paul Grippo, and Gretchen A. Repasky. "Abstract 3129: Regulation of expression and role of the pigment epithelium derived factor in Ras-mediated pancreatic oncogenesis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3129.

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Wambi, Joan S., Helen Kim, and V. Craig Jordan. "Abstract 607: Loss of pigment epithelium derived-factor (PEDF) is associated with breast cancer progression and antihormone drug resistance." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-607.

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Ueno, Sayaka, Eiji Sugihara, Tamotsu Sudo, and Hideyuki Saya. "Abstract 5202: Pigment epithelium-derived factor promotes tumor dissemination of ovarian cancer cells through an interaction with peritoneal immune system." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5202.

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Filleur, Stephanie, Natalie Pardue, Katherine Rinard, Jessica Gillen, and Thomas Nelius. "Abstract 3717: Pigment epithelium-derived factor prolongs survival and enhances thein vivoantitumor activities of low-dose chemotherapy in castration-refractory prostate cancer." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3717.

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Quinn, Margo A., Philip Fitchev, Mark Talamonti, Janardan Khandekar, Lijun Huang, Daniel L. Sweeney, Mona L. Cornwell, and Susan E. Crawford. "Abstract 1523: Trafficking of intracytoplasmic lipid droplets in pancreatic cancer cells by pigment epithelium-derived factor alters triacylglycerol metabolism and cellular invasion." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1523.

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Jimenez, Benilde, and Jose L. Orgaz. "Abstract LB-310: Changes in the gene expression profile of A375 human melanoma cells induced by over-expression of multifunctional pigment epithelium-derived factor." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-lb-310.

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Hirsch, Jennifer, Lisa C. Johnson, James Lemert, Katherine Rinard, Thomas Nelius, and Stephanie Filleur. "Abstract 3959: Pigment epithelium-derived factor blocks Interleukin-8 mediated proliferation in prostate cancer cells through PEDF-R/PLA2 receptor and regulation of the nuclear factor-κB and peroxisome proliferator activated receptor γ." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3959.

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