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Journal articles on the topic 'Pie VII'

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Published: 20 April 2024

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1

Rueda, M. "Introducción a la biomecánica del pie (VII)." Apunts. Medicina de l'Esport 39, no. 147 (January 2005): 37–41. http://dx.doi.org/10.1016/s1886-6581(05)76106-5.

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2

Hartemann, Philipe. "Arrestation du pape Pie VII au Vatican en 1809." Hegel N° 2, no. 2 (June 11, 2021): 235–38. http://dx.doi.org/10.3917/heg.112.0235.

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3

Ali, Mat. "PENGARUH METODE PENERAPAN MEDIA GRAFIS CHART PIE TERHADAP PRESTASI BELAJAR MATEMATIKA SISWA." INSPIRAMATIKA 6, no. 2 (December 30, 2020): 113–21. http://dx.doi.org/10.52166/inspiramatika.v6i2.2136.

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Penelitian ini bertujuan untuk meningkatkan aktifitas siswa dan meningkatkan prestasi siswa dengan menggunakan metode penerapan media grafis chart pie. Teknik analisis data menggunakan teknik analisis diskriptif kwantitatif dan kualitatif. Proses penelitian ini di lakukukan dalam dua siklus, masing masing terdiri dari empat tahap : (1) perencanaan, (2) pelaksanaan, (3) pelaksanaan, (4) observasi dan reflesi. Subyek penelitian adalah siswa siswa kelas VII B SMP Negeri 1 Sekaran Lamongan tahun pelajaran 2020/2021 berjumlah 25 siswa. Hasil penelitian ini menunjukkan adanya peningkatan aktifitas siswa dalam kegiatan pembelajaran dan juga menunjukkan peningkatan prestasi siswa, dengan demikian penggunaan metode penerapan media grafis chart pie digunakan pada pembelajaran mata pelajaran Matematika pokok bahasan operasional bilangan pecahan.
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4

Donze, Cécile, Patrick Hautecoeur, Samantha Demaille, Véronique Neuville, Sandra Vukusic, Christian Confavreux, and Maria Carmelita Scheiber Nogueira. "PIE VII 59/69 : sémiologie des infections urinaires dans la sclérose en plaques." Revue Neurologique 168 (April 2012): A45. http://dx.doi.org/10.1016/j.neurol.2012.01.111.

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5

Donzé, C., M. C. Scheiber Nogueira, S. Demaille, V. Neuville, S. Vukusic, and P. Hautecoeur. "PIE VII 59/69 : sémiologie des infections urinaires dans la sclérose en plaques." Revue Neurologique 169 (April 2013): A103. http://dx.doi.org/10.1016/j.neurol.2013.01.247.

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6

Palard, Jacques. "Ultramontanisme et contre-révolution en France au XIXe Siécle." Tocqueville Review 10 (December 1989): 65–83. http://dx.doi.org/10.3138/ttr.10.65.

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La Révolution française de 1789 représente sans conteste un facteur majeur de déstabilisation et de réaménagement des rapports entre l’Eglise et l’Etat hérités de l’Ancien Régime mais aussi entre l’Eglise catholique de France et la papauté. Conséquence apparemment paradoxale de la période révolutionnaire et post-révolutionnaire. le prestige de la papauté se trouve notablement réhaussé au début du XIX siécle. Alors que l’Eglise gallicane a perdu, avec la monarchie, son appui principal et proprement constitutif, le pape apparaît aux yeux d’unc part croissantc des catholiques comme le symbole du principe d’ordre et d’autoritl face aux forces politiques issues de la Révolution. L’attitude adoptée par le Directoire puis par Napoléon à l’égard de Pie VI et de Pie VII n’a évidemment pas peu contribué au développement de la popularité du chef de la catholicité.
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7

Sinamo, Risawan, and Munawir Pasaribu. "Upaya Meningkatkan Pemahaman Pelajaran PAI Dengan Menggunakan Metode Pembelajaran Simulasi Di Sekolah SMP Muhammadiyah 50 Medan." Jurnal Masyarakat Indonesia (Jumas) 1, no. 01 (January 31, 2022): 58–65. http://dx.doi.org/10.54209/jumas.v1i01.19.

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Based on field experience the understanding of the material received by students in pie lessons is still not optimal, this study uses the Pie simulation learning method. Muhammadiyah 50 Medan .Development of PKP Professional Capability which is carried out in one month. The location of the research subjects is class VII, VIII, IX. Islamic religious education in general can be understood as an effort to increase students' faith, understanding, appreciation and practice of the Islamic religion so that they become Muslim individuals who believe and are pious and have noble character in personal, community, nation and state life. This study is to determine the evaluation of the simulation process Islamic religious education learning at Muhammadiyah 50 Medan Middle School is in accordance with the planned program. a) By using the method the teacher has used media/approaches in the variation learning process
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8

Hermon-Belot, Rita. "Bernard Ardura, Le Concordat entre Pie VII et Bonaparte, 15 juillet 1801. Bicentenaire d’une réconciliation." Archives de sciences sociales des religions, no. 118 (April 1, 2002): 87–151. http://dx.doi.org/10.4000/assr.1583.

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9

Ticchi, Jean-Marc. "Les manifestations de la dévotion au pape au cours du voyage de Pie VII à Paris, 1804-1805." Revue d'Histoire de l'Eglise de France 93, no. 2 (January 2007): 429–60. http://dx.doi.org/10.1484/j.rhef.2.305018.

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10

Arshad, Hajra, Ejaz Mirza, and Memona Fida. "The Role of Salience and Common Grounds in Intercultural Communication: A Descriptive Study." Global Social Sciences Review VII, no. II (June 30, 2022): 90–99. http://dx.doi.org/10.31703/gssr.2022(vii-ii).09.

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Jokes are specific discourses that contain cultural, historical and region-specific references. In order to understand the salience of these discourses, the common ground of interlocutors is significantly important. The current study explores how non-natives English speakers comprehend English jokes. In addition, it aims to know the difficulties and the lexical issues encountered by Pakhtoon and Sindhi participants in interpreting English jokes. The researchers used a mixed-method approach for this study. The population of this study includes Pakhtoon and Sindhi undergraduate students.A sample of 20 students was selected and two types of tools were used to check the English jokes comprehension skills of participants. The socio-cognitive approach is used as a theoretical framework and the results of quantitative data were presented with the help of pie charts. Results of this study show that ethnic, religious, racial, and jokes having historic references are difficult to understand. Individuals' social knowledge of English culture is important for comprehending English jokes. Knowledge of semantic expressions, ample knowledge and wisdom of culture-specific words and idioms are important for identifying the salience aspects of English jokes.
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11

Nuraida, Elis Muslimah, and Ratu Ilma Indra Putri. "THE CONTEXT OF ARCHIPELAGO TRADITIONAL CAKE TO EXPLORE STUDENTS’ UNDERSTANDING IN INTEGERS DIVISION CLASS VII." Jurnal Pendidikan Matematika 14, no. 1 (December 31, 2019): 91–100. http://dx.doi.org/10.22342/jpm.14.1.7400.91-100.

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This study aims to explore the students’ mathematical understanding in integer division operation through the context of archipelago traditional cakes in class VII. This research is related to the Indonesian Realistic Mathematics Approach (PMRI) as a learning approach used. The methodology used in this study is Design Research consisting of three stages: preliminary design, experimental design, and retrospective analysis. The study was conducted on VII grade students of Palembang 1 Junior High School. The learning path (Hypothetical Learning Trajectory) in design research plays an important role as a research design and instrument. The Hypothetical Learning Trajectory (HLT) was developed together with a series of activities using the context of archipelago traditional cakes such as: omelette roll, bakpia, milk pie, etc. The medium used in this study was the Students’ Activity Sheet. The results of this study indicate that exploration using the context of traditional archipelago cakes can help students understanding in multiplication and division of integers. The conclusion of this study is the use of archipelago traditional cakes as starting point in mathematics learning in integer division operation material helps the students to explore their understanding in solving mathematics problems.
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12

Rodríguez Morales, Jesús, Alfonso Vigil-Escalera Guirado, and Alejandro Villa del Castillo. "La posible iglesia rural altomedieval de La Solana I (Móstoles, Madrid). El carácter central de su emplazamiento y sus vínculos con el poblamiento aldeano." Lucentum, no. 34 (December 15, 2015): 343. http://dx.doi.org/10.14198/lvcentvm2015.34.17.

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El hallazgo de diversos elementos de escultura decorativa altomedieval cerca del arroyo de El Soto (Móstoles, Madrid) da pie a plantear la existencia de una construcción monumental en el paraje de La Solana. La interpretación del edificio como una iglesia rural parece la hipótesis más parsimoniosa. El estilo de las piezas se corresponde con el de un conjunto de sitios de la provincia de Toledo, al Sur del Tajo, fechable entre finales del siglo VII y el siglo VIII d.C. A escasamente un kilómetro al Este de ese edificio prosperó desde al menos el siglo XIII la aldea de Arroyo de Viñas, aunque parece probable que ya estuviera despoblada a finales del siglo XIV. Su ermita de San Marcos constituyó un polo de atracción muy estable para un grupo de aldeas vecinas hasta inicios del siglo XIX.
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13

Hernández Villarroel, Luis Alfredo, Jehan Lym Lanz Luna, José Zavala Valladares, and Carolina Machuca. "Síndromede Moebius. A propósito de un caso." Revista Cientifica Ciencia Medica 19, no. 2 (December 31, 2016): 60–64. http://dx.doi.org/10.51581/rccm.v19i2.215.

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Anomalía congénita caracterizada por afectación del VI y VII par craneano que determina una parálisis facial, uni o bilateral, aunque el compromiso puede ser más extenso. Se describe paciente masculino de 4 años de edad, obtenido por cesárea, con antecedentes de amenaza de aborto en cuatro oportunidades a partir de la décima semana de gestación; en el período de lactancia presentó dificultad para la succión y deglución. Al examen físico, facies inexpresiva, boca “en carpa”, parálisis facial bilateral, estrabismo, nistagmos, puente nasal ancho, micronagtia, paladar hendido, pie equino varo bilateral y sindactilia en mano derecha. Se relaciona con eventos y fármacos (mi­soprostol) que puedan producir una disrupción vascular e insuficiencia placentaria. Se sugiere como causa, la afec­ción hipóxico/isquémica transitoria del feto debido a alteraciones en la circulación materno-fetal durante primer trimestre de embarazo, por amenaza de aborto y probablemente exposición a teratógenos como el misoprostol.
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14

Zając, Paweł. "Jean-Marc Ticchi, Le Voyage de Pie VII à Paris pour le sacre de Napoléon (1804-1805). Religion, politique et diplomatie." Roczniki Teologiczne 62, no. 4 (2015): 291–302. http://dx.doi.org/10.18290/rt.2015.62.4-22.

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15

Pinon, Esther. "Jean-Marc Ticchi, Le Voyage de Pie VII à Paris pour le sacre de Napoléon (1804-1805). Religion, politique et diplomatie." Studi Francesi, no. 175 (LIX | I) (April 1, 2015): 155–56. http://dx.doi.org/10.4000/studifrancesi.478.

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16

Croce, Giuseppe Maria. "Les papiers des cardinaux secrétaires d'État, de Pie VII à Benoît XV dans la série des Spogli aux Archives secrètes Vaticanes." Mélanges de l’École française de Rome. Italie et Méditerranée 110, no. 2 (1998): 533–43. http://dx.doi.org/10.3406/mefr.1998.4577.

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17

Iniesta Sepúlveda, Víctor. "Joana Biarnés. Madrid / Moda a pie de calle. Madrid: Sala Canal de Isabel II, 28-II-2023 a 23-VII-2023." Archivo Español de Arte 96, no. 383 (October 5, 2023): 353–54. http://dx.doi.org/10.3989/aearte.2023.47.

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18

Varanasi, Yasaswini Vishnu Priya, Subhakara Rao Isetty, Padmashree Revadi, Divya Balakrishnan, Shaik Hajira, Madamsetty Srinivasa Prasad, Gouri Shankar Laha, et al. "Molecular and Morphological Characterization of Introgression Lines with Resistance to Bacterial Leaf Blight and Blast in Rice." Plants 12, no. 16 (August 21, 2023): 3012. http://dx.doi.org/10.3390/plants12163012.

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The present study evaluates marker assisted forward breeding (MAFB)-derived disease resistant introgression lines (ILs) which do not have the targeted resistance genes for bacterial blight (xa5 + xa13 + Xa21) and blast (Pi2 + Pi9 + Pi54). The ILs were derived in the background of two elite rice cultivars, Krishna Hamsa [Recurrent Parent 1 (RP1)] and WGL 14 (RP2), involving multi-parent inter-crossing. Molecular characterization with gene specific markers for seven reported resistance genes each for bacterial blight (Xa33, Xa38, xa23, Xa4, xa8, Xa27 and Xa41) and blast (Pi1, Pi20, Pi38, Pib, Pitp, Pizt and Pi40) revealed the presence of xa8 and Xa38, in addition to the targeted xa5, xa13 and Xa21 for bacterial blight resistance and Pi1, Pi38, Pi40, Pi20, Pib and Pipt, in addition to the targeted Pi9 and Pi54, for blast resistance in various combinations. A maximum of nine resistance genes xa5 + Xa21 + Pi54 + xa8 + Pipt + Pi38 + Pi1 + Pi20 + Pib was observed in RP1-IL 19030 followed by eight genes xa5 + xa13 + Xa21 + xa8 + Pi9 + Pipt + Pi1 + Pi20 in two RP2-ILs, 19344 and 19347. ANOVA revealed the presence of significant variability for all the yield traits except “days to 50% flowering” (DFF). Box plots depicted the seasonal differences in the phenotypic expression of the yield traits. There was significant positive association of grain yield with days to flowering, tiller number and panicle number. Thousand grain weight is also significantly and positively correlated with grain yield. On the contrary, grain yield showed a significantly negative association with plant height. Multi-parent selective inter-crossing in the present study not only led to the development of high yielding disease resistant ILs but also enhanced recovery of the recurrent parent via selection for essential morphological features. More than 90.0% genetic similarity in the ILs based on SNP-based background selection demonstrated the success of multi-parent selective intercrossing in the development of disease resistant NILs.
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19

Routhier, Gilles. "Jean LeBlanc, Dictionnaire biographique des cardinaux du xix siècle. Contribution à l’histoire du Sacré Collège sous les pontificats de Pie VII, Léon XII, Pie VIII, Grégoire XVI, Pie IX et Léon XIII, 1800-1903. Montréal, Wilson & Lafleur Ltée (coll. « Gratianus », série « Instruments de recherche »), 2007, 1 079 p." Laval théologique et philosophique 64, no. 2 (2008): 558. http://dx.doi.org/10.7202/019519ar.

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20

Durand, Jean-Dominique. "Jacques-Olivier Boudon, Rémy Hême de Lacotte (dir.), La crise concordataire. Catholiques français et italiens entre Pie VII et Napoléon, 1808-1814." Archives de sciences sociales des religions, no. 176 (December 31, 2016): 276. http://dx.doi.org/10.4000/assr.28189.

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21

Unger, Gérard. "Les débats parlementaires lors de la loi de 1905." Matériaux pour l’histoire de notre temps N° 78, no. 2 (April 1, 2005): 8–15. http://dx.doi.org/10.3917/mate.078.0002.

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Résumé Depuis le signature du Concordat en 1801 par Bonaparte et Pie VII jusqu’à la loi de Séparation de l’église et de l’état, un siècle plus tard, en décembre 1905, Gérard Unger retrace les longs débats parlementaires qui ont eu lieu à la chambre des députés dès 1903 au sein d’une Commission composée de 33 membres et créée pour étudier le sujet. Cette Commission est présidée par Ferdinand Buisson, ancien collaborateur de Jules Ferry, et Aristide Briand comme rapporteur. Briand va devoir à la fois s’opposer aux adversaires de droite de la Séparation, mais aussi à ses propres « amis ». Le texte achevé est soumis à la chambre le 21 mars, où s’ouvre la discussion qui va durer jusqu’au 3 juillet. Au Sénat, la discussion s’ouvre le 9 novembre. Le 6 décembre, la loi est adoptée par le Sénat : 181 voix pour, 102 voix contre. Elle est publiée au Journal Officiel le 11 décembre 1905. Un siècle plus tard, la loi de décembre 1905 a été modifiée neuf fois.
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22

Azizah, Fitria Nurul, Mahmudi Mahmudi, Kristinawati Kristinawati, and Helti Lygia Mampouw. "UPAYA MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH SISWA KELAS VII B SMP NEGERI 2 SALATIGA PADA MATERI PENYAJIAN DATA MELALUI MODEL PROBLEM BASED LEARNING (PBL)." Jurnal Lebesgue : Jurnal Ilmiah Pendidikan Matematika, Matematika dan Statistika 4, no. 2 (August 30, 2023): 1148–61. http://dx.doi.org/10.46306/lb.v4i2.396.

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This study aims to enhance students' problem-solving skills and learning outcomes on data presentation and interpretation in the form of pie charts and measures of the center of the data in the single data. This research is a collaborative classroom action research (PTKK). The study employs the Problem-Based Learning (PBL) model, conducted at SMP Negeri 2 Salatiga in class VII B with 32 students. The results indicate an improvement in students' problem-solving abilities for each indicator. In cycle I, the student's ability to understand the problem was 36.2 %, which increased by 42.2 % to 78.4 % in cycle II. Furthermore, students' making a plan skill in cycle I was 51.2 %, increasing by 26.9 % to 78.1 % in cycle II. The student's ability to execute the plan increased by 19.6 % from 55.7 % in cycle I to 75.3 % in cycle II. The student's ability to look back and reflect in cycle I was 42.2 %, and in cycle II, it was 75 %, an increase of 32.8 %. The study also showed an improvement in learning outcomes. In cycle I, the classical student mastery level was 40.6 %, with an average learning outcome of 67.2. In contrast, in cycle II, the classical student mastery level was 75 %, with an average learning outcome of 78.2. In this case, the classical student mastery level increased by 34.4 %, with an average student learning outcome increase of 11. Based on these results, the Problem-Based Learning (PBL) model can enhance students' problem-solving abilities
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23

Hursin, Mathieu, Dimitri Rochman, Alexander Vasiliev, Hakim Ferroukhi, and Andreas Pautz. "IMPACT OF VARIOUS SOURCE OF COVARIANCE INFORMATION ON INTEGRAL PARAMETERS UNCERTAINTY DURING DEPLETION CALCULATIONS WITH CASMO-5." EPJ Web of Conferences 247 (2021): 09005. http://dx.doi.org/10.1051/epjconf/202124709005.

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This paper describes the effect of input uncertainties on a set of integral parameters (kinf, nuclide compositions) associated with the validation of CASMO-5 against PIE data. The nuclear data under consideration are the cross-sections, fission spectrum and neutron multiplicities and fission yields. Various sources of covariance information are considered, novel ones (ENDFB-VIII.0, JEFF-3.3) as well as more widely distributed ones (JENDL-4.0, ENDF/B-VII.1, Scale 6.1 and Scale 6.2). All possible nuclide reaction pairs (cross sections, fission spectrum and averaged number of neutron per fission) have been perturbed, e.g. all isotopes available in both the respective covariance libraries and the CASMO-5 library. The evolution of the uncertainty estimates with exposure is complemented with sensitivity analysis to determine the main contributors to the uncertainty. The Pearson coefficient defined between the model output and a given input is used in this work to assess the part of the variance in the model output coming from the considered input uncertainty. It is a very promising measure of sensitivity as it is computationally cheap even though it assumes linearity of the output with respect to input perturbations. The evolution of the uncertainty with exposure, both in terms of trends and magnitude are however very different. Sensitivity analysis allows determining why the trends and magnitudes are different.
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24

Casas, Santiago. "Jean-Marc Ticchi, Le voyage de Pie vii à Paris pour le sacre de Napoléon (1804-1805). Religion, politique et diplomatie Honoré Champion, París 2013, 599 pp." Anuario de Historia de la Iglesia 23 (March 27, 2015): 615. http://dx.doi.org/10.15581/007.23.1658.

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25

Pantiwati*, Yuni, Deny Fatmawati, and Rifqi Yassirul Haqqi. "Junior High School Students' Skills in Making Posters Through the Blended Li-Pro-GP Learning Model." Jurnal IPA & Pembelajaran IPA 6, no. 4 (December 24, 2022): 382–92. http://dx.doi.org/10.24815/jipi.v6i4.27841.

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The skill of making a good poster is that it must meet the quality requirements of the poster. A good poster quality consists of clarity of content, completeness of components, aesthetics, composition of text and images. To train students' poster making skills, a supportive learning model is needed. The project based literacy that integrates school literacy movement strengthening character education (Li-Pro-GP) program in the implementation of learning. The purpose of the study was to describe the skills of making posters for junior high school students after using the Li-Pro-GP learning model. The research method uses classroom action research (CAR) at SMPN 23 Malang City, carried out in 2 blended cycles. The results showed that students' skills had increased in making posters based on science concepts. The population of this research is class VII odd semester 2020/2021 students of SMPN 23 Malang. The sample from the research of class VIIC SMPN 23 Malang is 25 students with purposive sampling technique. Data collection with student activity observation sheets includes field notes and poster making skills with poster making indicators. The research data were analyzed descriptively and qualitatively presented with bar and pie charts with an explanation for each percentage on the diagram of the 25 students, it shows that 20% of the students in the very good poster category, 16% of the students in the good category and 64% of the students in the moderate category
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26

Flores Sánchez, V. H., R. A. Vázquez García, O. Coreño Alonso, J. Coreño Alonso, Ma I. Reyes Valderrama, Eduardo Arias, Ivana Moggio, and M. Martínez García. "Preparation of Oriented Nanofilms of Oligo(Phenylimines) Synthesized by Mechanochemistry for Optoelectronic Devices." Materials Science Forum 691 (June 2011): 83–91. http://dx.doi.org/10.4028/www.scientific.net/msf.691.83.

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Oligo(phenylimines) hereafter named PI6, PI8 and PI9 were synthesized by condensation reaction between the terephtalaldehyde and diamines of different length size (diaminohexane, diaminooctane and diaminononane) via mechanochemistry. The reactions were carried out without solvent or catalyst and completed after only 90 minutes. The products were characterized by 1H-NMR, UV-Vis, FT-IR spectroscopy, GPC, DSC and Small angle X-ray diffraction. Thin films were prepared by spin coating from concentrated solutions on glass and quartz substrates and mechanically rubbed with a polyacrylonitrile tissue. The oriented films were studied by both Laser Scanning Confocal Microscopy (LSCM) and UV-Vis spectroscopy. With this last technique, the higher optical dichroism was observed for PI6. The oriented films of this oligo(phenylimine) were thus used as patterns to induce molecular orientation of a fluorescent phenyleneethynylene polymer in order to obtain polarized light emission.
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27

Gomez Osuna, Rosario. "Enterramientos Infantiles Altomedievales en La Cabilda, Hoyo de Manzanares, Madrid. Early Middle Ages infant burials in La Cabilda, Hoyo de Manzanares, Madrid (Spain)." Territorio, Sociedad y Poder 13, no. 13 (November 25, 2018): 23. http://dx.doi.org/10.17811/tsp.13.2018.23-47.

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Se presentan tres inhumaciones infantiles documentadas en el yacimiento Altomedieval de La Cabilda, Hoyo de Manzanares, Madrid, en la campaña de excavaciones del año 2017. Tienen la peculiaridad de localizarse asociadas a una estructura no funeraria, habitacional y de carácter auxiliar. El yacimiento de La Cabilda es un asentamiento aldeano rural situado en el pie de la Sierra de Guadarrama, con cronologías del siglo VII d.C. Cuenta con 23 estructuras de habitación y productivas, y con enterramientos dispersos en sepulturas excavadas en roca granítica, de tipo ovalado, en las proximidades de los edificios. Para la interpretación de las tumbas infantiles aparecidas y del espacio funerario elegido, se realiza un análisis de datos conocidos sobre este tipo singular de enterramientos y se incluyen ejemplos de inhumaciones infantiles de similar cronología de los yacimientos Altomedievales de la Sierra de Guadarrama.Results of the study of three infant burials located in the Early Middle Ages archaeological site of La Cabilda, Hoyo de Manzanares, Madrid (Spain), as found during the excavation campaign of 2017. The burials have the peculiarity of being linked to an auxiliar dwelling structure, not associated with funerary purposes.The La Cabilda archaeological site, in Hoyo de Manzanares, corresponds to a farming settlement dated in the 7th century CE and located at the hem of Madrid’s Guadarrama Mountain Range. The site is comprised of 23 farming and housing building structures with additional scattered burials, oval-shaped and excavated in granite rock, located in the vicinity of the buildings.In order to interpret the infant burials and their associated funerary area, we perform an analysis of known data on this type of sepultures, including examples of other, similarly dated, infant burials found in Early Middle Ages archaeological sites in the Guadarrama Mountain Range.
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28

Bhoopathi, Praveen, Amit Kumar, Anjan K. Pradhan, Santanu Maji, Padmanabhan Mannangatti, Jolene J. Windle, Mark A. Subler, et al. "Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity." Journal for ImmunoTherapy of Cancer 11, no. 11 (November 2023): e007624. http://dx.doi.org/10.1136/jitc-2023-007624.

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BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer without effective therapies and with poor prognosis, causing 7% of all cancer-related fatalities in the USA. Considering the lack of effective therapies for this aggressive cancer, there is an urgent need to define newer and more effective therapeutic strategies. Polyinosine–polycytidylic acid (pIC) is a synthetic double-stranded RNA (dsRNA) which directly activates dendritic cells and natural killer cells inhibiting tumor growth. When pIC is delivered into the cytoplasm using polyethyleneimine (PEI), pIC-PEI, programmed-cell death is induced in PDAC. Transfection of [pIC]PEIinto PDAC cells inhibits growth, promotes toxic autophagy and also induces apoptosis in vitro and in vivo in animal models.MethodsThe KPC transgenic mouse model that recapitulates PDAC development in patients was used to interrogate the role of an intact immune system in vivo in PDAC in response to [pIC]PEI. Antitumor efficacy and survival were monitored endpoints. Comprehensive analysis of the tumor microenvironment (TME) and immune cells, cytokines and chemokines in the spleen, and macrophage polarization were analyzed.ResultsCytosolic delivery of [pIC]PEIinduces apoptosis and provokes strong antitumor immunityin vivoin immune competent mice with PDAC. The mechanism underlying the immune stimulatory properties of [pIC]PEIinvolves Stat1 activation resulting in CCL2 and MMP13 stimulation thereby provoking macrophage polarization. [pIC]PEIinduces apoptosis via the AKT-XIAP pathway, as well as macrophage differentiation and T-cell activation via the IFNγ-Stat1-CCL2 signaling pathways in PDAC. In transgenic tumor mouse models, [pIC]PEIpromotes robust and profound antitumor activity implying that stimulating the immune system contributes to biological activity. The [pIC]PEIanti-PDAC effects are enhanced when used in combination with a standard of care (SOC) treatment, that is, gemcitabine.ConclusionsIn summary, [pIC]PEItreatment is non-toxic toward normal pancreatic cells while displaying strong cytotoxic and potent immune activating activities in PDAC, making it an attractive therapeutic when used alone or in conjunction with SOC therapeutic agents, potentially providing a safe and effective treatment protocol with translational potential for the effective therapy of PDAC.
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Roychoudhury, Siddhartha, Tracy L. Twinem, Kelly M. Makin, Mark A. Nienaber, Chuiying Li, Timothy W. Morris, Benoit Ledoussal, and Carl E. Catrenich. "Staphylococcus aureus Mutants Isolated via Exposure to Nonfluorinated Quinolones: Detection of Known and Unique Mutations." Antimicrobial Agents and Chemotherapy 45, no. 12 (December 1, 2001): 3422–26. http://dx.doi.org/10.1128/aac.45.12.3422-3426.2001.

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ABSTRACT The in vitro development of resistance to the new nonfluorinated quinolones (NFQs; PGE 9262932, PGE 4175997, and PGE 9509924) was investigated in Staphylococcus aureus. At concentrations two times the MIC, step 1 mutants were isolated more frequently with ciprofloxacin and trovafloxacin (9.1 × 10−8 and 5.7 × 10−9, respectively) than with the NFQs, gatifloxacin, or clinafloxacin (<5.7 × 10−10). Step 2 and step 3 mutants were selected via exposure of a step 1 mutant (selected with trovafloxacin) to four times the MICs of trovafloxacin and PGE 9262932. The step 1 mutant contained the known Ser80-Phe mutation in GrlA, and the step 2 and step 3 mutants contained the known Ser80-Phe and Ser84-Leu mutations in GrlA and GyrA, respectively. Compared to ciprofloxacin, the NFQs were 8-fold more potent against the parent and 16- to 128-fold more potent against the step 3 mutants. Mutants with high-level NFQ resistance (MIC, 32 μg/ml) were isolated by the spiral plater-based serial passage technique. DNA sequence analysis of three such mutants revealed the following mutations: (i) Ser84-Leu in GyrA and Glu84-Lys and His103-Tyr in GrlA; (ii) Ser-84Leu in GyrA, Ser52-Arg in GrlA, and Glu472-Val in GrlB; and (iii) Ser84-Leu in GyrA, Glu477-Val in GyrB, and Glu84-Lys and His103-Tyr in GrlA. Addition of the efflux pump inhibitor reserpine (10 μg/ml) resulted in 4- to 16-fold increases in the potencies of the NFQs against these mutants, whereas it resulted in 2-fold increases in the potencies of the NFQs against the parent.
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30

Jia, Hepeng. "Chinese manufacturers vie for piece of outsourcing pie." Nature Biotechnology 25, no. 12 (December 2007): 1337–38. http://dx.doi.org/10.1038/nbt1207-1337.

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LE NEINDRE, P., and J. P. GAREL. "Adaptation des bovins aux milieux d’élevage." INRAE Productions Animales 3, no. 3 (July 3, 1990): 189–94. http://dx.doi.org/10.20870/productions-animales.1990.3.3.4373.

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Des veaux de races Pie-Noire et Salers ont été observés dans différentes conditions d’élevage et à différentes périodes de leur vie. S’ils sont avec leur mère dès la naissance, leurs activités ne sont pas statistiquement différentes entre les deux races. En revanche lorsqu’ils sont seuls, les veaux Pie-Noirs sont plus actifs que les Salers, ils boivent plus facilement le lait au seau, ils ingèrent plus d’aliment solide et ont finalement une meilleure croissance. La précocité sexuelle des Pie- Noires est supérieure à celle des Salers. Ces différences peuvent être interprétées en termes d’adaptations aux différents milieux d’élevage. Le terme « rusticité », trop imprécis, devrait être évité.
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Ayukawa, Yasunori, Wakana Oshiro, Ikiru Atsuta, Akihiro Furuhashi, Ryosuke Kondo, Yohei Jinno, and Kiyoshi Koyano. "Long Term Retention of Gingival Sealing around Titanium Implants with CaCl2 Hydrothermal Treatment: A Rodent Study." Journal of Clinical Medicine 8, no. 10 (September 29, 2019): 1560. http://dx.doi.org/10.3390/jcm8101560.

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We previously reported that CaCl2 hydrothermal-treated (Ca-HT) titanium (Ti) implants induced a tight sealing at the interface between the implant and peri-implant epithelium (PIE) after implantation. However, it is not clear how long this improved epithelium sealing can be maintained. We subsequently investigated whether the positive effect of Ca-HT to promote sealing between the PIE and implant was sustained longer term. Maxillary molars were extracted from rats and replaced with either Ca-HT implants (Ca-HT group), distilled water-HT implants (DW-HT group) or non-treated implants (control group). After 16 weeks, the majority of implants in the Ca-HT group remained at the maxillary with no apical extension of the PIE. Conversely, half the number of control implants was lost following down-growth of the PIE. The effect of Ca-HT on migration and proliferation of rat oral epithelial cells (OECs) was also investigated. In OECs cultured on Ca-HT Ti plates, protein expression in relation to cell migration decreased, and proliferation was higher than other groups. Surface analysis indicated HT enhanced the formation of surface TiO2 layer without altering surface topography. Consequently, Ca-HT of Ti reduced PIE down-growth via tight epithelial attachment to the surface, which may enhance implant capability for a longer time post-implantation.
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Wu, Youjun, Huaiying Zhang, and Erik E. Griffin. "Coupling between cytoplasmic concentration gradients through local control of protein mobility in theCaenorhabditis eleganszygote." Molecular Biology of the Cell 26, no. 17 (September 2015): 2963–70. http://dx.doi.org/10.1091/mbc.e15-05-0302.

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Cell polarity is characterized by the asymmetric distribution of factors at the cell cortex and in the cytoplasm. Although mechanisms that establish cortical asymmetries have been characterized, less is known about how persistent cytoplasmic asymmetries are generated. During the asymmetric division of the Caenorhabditis elegans zygote, the PAR proteins orchestrate the segregation of the cytoplasmic RNA-binding proteins MEX-5/6 to the anterior cytoplasm and PIE-1, POS-1, and MEX-1 to the posterior cytoplasm. In this study, we find that MEX-5/6 control the segregation of GFP::PIE-1, GFP::POS-1, and GFP::MEX-1 by locally increasing their mobility in the anterior cytoplasm. Remarkably, PIE-1, POS-1, and MEX-1 form gradients with distinct strengths, which correlates with differences in their responsiveness to MEX-5/6. We show that MEX-5/6 act downstream of the polarity regulators PAR-1 and PAR-3 and in a concentration-dependent manner to increase the mobility of GFP::PIE-1. These findings suggest that the MEX-5/6 concentration gradients are directly coupled to the establishment of posterior-rich PIE-1, POS-1, and MEX-1 concentration gradients via the formation of anterior-fast, posterior-slow mobility gradients.
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Bozzone, Chiara. "The Origin of the Caland System and the Typology of Adjectives." Indo-European Linguistics 4, no. 1 (2016): 15–52. http://dx.doi.org/10.1163/22125892-00401003.

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This paper argues that the Caland system rests on a Pre-PIE verb-like adjective class, which formed root aorists. The Caland system as we know it came to be when PIE shifted to having a noun-like adjective class, and the Caland roots had to be adapted to the new system via derivation (while the old root aorists were gradually lost). Evidence for root aorists to Caland roots in Vedic is reviewed, and a typologically informed scenario for the shift is proposed. Finally, the paper argues that this scenario clarifies the origin of the *-eh1- stative in Indo-European (following Jasanoff (2002–2003)’s account), which would have arisen as PIE shifted from verb-like adjectives to nominal adjectives, and came to have a switch adjective system based on aspect.
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Gergs, Ulrich, Peter Boknik, Wilhelm Schmitz, Andreas Simm, Rolf-Edgar Silber, and Joachim Neumann. "A positive inotropic effect of ATP in the human cardiac atrium." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 4 (April 2008): H1716—H1723. http://dx.doi.org/10.1152/ajpheart.00945.2007.

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We studied contractile effects in isolated electrically driven (1 Hz) atrial preparations from patients undergoing cardiac bypass surgery. ATP concentration dependently (10, 30, and 100 μM) and rapidly decreased force of contraction (negative inotropic effect, NIE) and thereafter more slowly increased force of contraction. The maximum positive inotropic effect (PIE) at 100 μM ATP amounted to 152% of the predrug value ( n = 9) and was stable and could be washed out fast and completely. The PIE did not affect time parameters of contraction (time to peak tension and time of relaxation). Moreover, a similar NIE and PIE were noted with adenosine 5′- O-(2-thiotriphosphate) (100 μM). In contrast 2-methyl-thio-ATP did not exert a NIE but only a PIE. In a second set of experiments, preparations were first incubated for 30 min with purinoreceptor antagonists and, in their continuous presence, 100 μM ATP was applied. However, the PIE and NIE of ATP could neither be blocked with suramin (100 and 500 μM), pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid (50 μM), nor reactive blue 2 (30, 100, and 500 μM), which are known blockers for subtypes of P2 receptors, or 1,3-dipropyl-cyclopentvl-xanthine (1 and 10 μM), a subtype (A1 adenosine) P1 receptor blocker. Likewise, the inhibitor of phospholipase C (PLC) activity (U-73122) and the inhibitor of adenylate cyclase activity (SQ-022563) (10 μM each) failed to affect the NIE and the PIE of ATP. We tentatively suggest that the PIE of ATP might be mediated via P2X4-like receptors. In summary, we describe a novel biphasic effect of ATP on force contraction in the isolated human atrium. It is conceivable that ATP plays a physiological role in the human heart, for instance, after cardiac injury to sustain contractility.
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Ojeda, Maritza, and Reinaldo Pire. "EFECTO DE LA SALINIDAD EN DOS PORTAINJERTOS DE VID CULTIVADOS A PIE FRANCO O INJERTADOS." Revista Fitotecnia Mexicana 34, no. 1 (March 31, 2011): 43. http://dx.doi.org/10.35196/rfm.2011.1.43.

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La viticultura tropical se desarrolla en zonas de baja humedad donde el agua de riego frecuentemente presenta salinidad de mediana a alta. El objetivo de esta investigación fue evaluar la respuesta a la salinidad de los portainjertos de vid ‘Criolla Negra’ y ‘Villanueva’ conducidos tanto a pie franco como injertados. Las plantas se cultivaron en recipientes de 5 L llenados con arena silícea y regadas con soluciones de NaCl + CaCl2 (1:2), ajustadas a conductividades eléctricas (CE) de 0.75 (testigo), 2.25, 3.75, 5.25 y 6.75 dS m-1. El material vegetal y los tratamientos salinos se evaluaron en arreglo factorial mediante un diseño completamente al azar con cinco repeticiones y dos plantas por unidad experimental. En condiciones de alta salinidad el crecimiento de la planta fue sólo 1/3 de su crecimiento potencial, la densidad longitudinal de raíces disminuyó en 67 % y la longitud específica en 38 %, la biomasa aérea en 64 % y la radical en 58 %. La relación raíz/parte aérea de los materiales aumentó a medida que se incrementó el nivel salino. El portainjerto ‘Criolla Negra’, tanto a pie franco como injertado, resultó más afectado en valores altos de CE que ‘Villanueva’, y la supervivencia de portainjertos a pie franco fue superior en comparación con los materiales injertados. Los niveles de clorofila y el rendimiento cuántico fotosintético disminuyeron al aumentar la dosis salina. ‘Villanueva’ presentó el mayor contenido de prolina y promedió mayor biomasa y longitud radical. Los niveles de K, Ca, Na y Cl tendieron a aumentar con la salinidad. El crecimiento de los injertos fue hasta 2/3 menor al de los portainjertos a pie franco. La fisiología de los materiales se afectó a valores bajos de CE (0.75 a 2.25 dS m-1), pero el crecimiento vegetativo sólo se afectó con salinidades superiores (CE: 2.25 a 3.75 dS m-1).
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37

Pavse, Brahma S., and Josiah P. Hanna. "Scaling Marginalized Importance Sampling to High-Dimensional State-Spaces via State Abstraction." Proceedings of the AAAI Conference on Artificial Intelligence 37, no. 8 (June 26, 2023): 9417–25. http://dx.doi.org/10.1609/aaai.v37i8.26128.

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We consider the problem of off-policy evaluation (OPE) in reinforcement learning (RL), where the goal is to estimate the performance of an evaluation policy, pie, using a fixed dataset, D, collected by one or more policies that may be different from pie. Current OPE algorithms may produce poor OPE estimates under policy distribution shift i.e., when the probability of a particular state-action pair occurring under pie is very different from the probability of that same pair occurring in D. In this work, we propose to improve the accuracy of OPE estimators by projecting the high-dimensional state-space into a low-dimensional state-space using concepts from the state abstraction literature. Specifically, we consider marginalized importance sampling (MIS) OPE algorithms which compute state-action distribution correction ratios to produce their OPE estimate. In the original ground state-space, these ratios may have high variance which may lead to high variance OPE. However, we prove that in the lower-dimensional abstract state-space the ratios can have lower variance resulting in lower variance OPE. We then highlight the challenges that arise when estimating the abstract ratios from data, identify sufficient conditions to overcome these issues, and present a minimax optimization problem whose solution yields these abstract ratios. Finally, our empirical evaluation on difficult, high-dimensional state-space OPE tasks shows that the abstract ratios can make MIS OPE estimators achieve lower mean-squared error and more robust to hyperparameter tuning than the ground ratios.
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38

Roca, M., M. Balasch, J. Segalés, M. Calsamiglia, E. Viaplana, A. Urniza, K. Hattermann, A. Mankertz, J. Plana-Durán, and M. Domingo. "In vitro and in vivo characterization of an infectious clone of a European strain of porcine circovirus type 2." Journal of General Virology 85, no. 5 (May 1, 2004): 1259–66. http://dx.doi.org/10.1099/vir.0.79836-0.

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The aim of this study was to describe the generation of a PCV2 (porcine circovirus type 2) infectious clone (pIC-PCV2) and its infectivity under in vitro and in vivo conditions. The constructed pIC-PCV2 contained the whole PCV2 genome from a German isolate together with a partial duplication of 467 bp. PK-15 cells were transfected with pIC-PCV2 and an indirect immune fluorescence assay (IFA) was performed 7 days post-transfection. The PCV2 Cap gene was expressed in approximately 20 % of the cultured cells, and only the recombination product, and not pIC-PCV2, was subsequently detected by PCR and Southern blot. This result indicated that infection by pIC-PCV2 delivered genomic PCV2 DNA specifically into susceptible cells and led to the expression of a functional virus genome. Eighteen 30- to 40-day-old conventional pigs were distributed into three groups. Group 1 pigs (n=6) were inoculated intranasally (i.n.) with a Spanish isolate of PCV2 propagated in cell culture; pigs from group 2 (n=6) were inoculated with pIC-PCV2 intramuscularly (i.m.), and the last group of pigs (n=6) was inoculated with pIC-PCV2 intraperitoneally (i.p.). All pigs remained clinically healthy during the whole experimental period (35 days). Pigs that received pIC-PCV2 i.p. and i.m., as well as those PCV2 i.n. inoculated, became infected based on an in situ hybridization (ISH), PCR, TaqMan PCR and serological results. The results of this study confirm that cloned PCV2 genomic DNA is infectious both in vitro and in vivo, and is able to cause PMWS-like lesions in i.p. and i.m. experimentally inoculated pigs.
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39

Luo, Shi-Zhong, Yan-Mei Li, Yan-Ling Niu, Yi Chen, Yu-Yang Jiang, Jing Chen, and Yu-Fen Zhao. "Characterization of Electrospray Ionization Mass Spectrometry for N-Diisopropyloxyphosphoryl Dipeptide Methyl Esters." European Journal of Mass Spectrometry 11, no. 1 (February 2005): 107–17. http://dx.doi.org/10.1255/ejms.733.

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A systematic study of the fragmentation pattern of N-diisopropyloxyphosphoryl (DIPP) dipeptide methyl esters in an electrospray ionization (ESI) tandem mass spectrometry (MS/MS) was presented. A combination of accurate mass measurement and tandem mass spectrometry had been used to characterize the major fragment ions observed in the ESI mass spectrum. It was found that the alkali metal ions acted as a fixed charge site and expelled the DIPP group after transferring a proton to the amide nitrogen. For all the N-phosphoryl dipeptide methyl esters, under the activation of a metal ion, the rearrangement product ion at m/z 163 was observed and confirmed to be the sodium adduct of phosphoric acid mono-isopropyl esters (PAIE), via a specific five-membered penta-coordinated phosphorus intermediate. However, no rearrangement ion was observed when a β-amino acid was at the N-terminal. This could be used to develop a novel method for differentiating isomeric compounds when either α- or β-amino acid are at the N-terminus of peptides. From the [M + Na]+ ESI-MS/MS spectra of N-phosphoryl dipeptide methyl esters (DIPP – Xaa1 – Xaa2 – OMe), the peaks corresponding to the [M + Na – Xaa1 – C3H6]+ were observed and explained. The [M + Na]+ ESI-MS/MS spectra of N-phosphoryl dipeptide methyl esters with Phe located in the C-terminal, such as DIPP–Val–Phe–OMe, DIPP–Leu–Phe–OMe, DIPP–Ile–Phe–OMe, DIPP–Ala–Phe–OMe and DIPP–Phe–Phe–OMe, had characteristic fragmentation. Two unusual gas-phase intramolecular rearrangement mechanisms were first proposed for this fragmentation. These rearrangements were not observed in dipeptide methyl ester analogs which did not contain the DIPP at the N-terminal, suggesting that this moiety was critical for the rearrangement.
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40

Rüst, Annina. "A Piece of the Pie Chart: Feminist Robotics." Leonardo 47, no. 4 (August 2014): 360–66. http://dx.doi.org/10.1162/leon_a_00841.

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This paper analyzes the robotic gallery installation A Piece of the Pie Chart. The project addresses gender inequity in the tech world. It consists of a computer workstation and a food robot. The food robot puts pie charts onto edible, pre-baked pies. They depict the gender gap in technical environments. Visitors use the robot to create pies. Pictures of the pies are disseminated via Twitter, and the physical pies are mailed to the places where the data originated. In the following text, the author disassembles the machine in the context of feminist theory, feminist technology research, visualization, and political robotics.
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41

Hawkins, P. T., L. Stephens, H. Welch, C. Ellson, S. Gobert, A. B. Holmes, J. W. Thuring, et al. "Signalling via PI3-kinases." Biochemical Society Transactions 29, no. 5 (October 1, 2001): A109. http://dx.doi.org/10.1042/bst029a109b.

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42

Mallick, Suman, Tejpal Singh, and Soumik Podder. "IoT based Smart Mirror Using Raspberry PI." International Journal for Research in Applied Science and Engineering Technology 11, no. 1 (January 31, 2023): 460–67. http://dx.doi.org/10.22214/ijraset.2023.48583.

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Abstract: This paper describes the design, construction and working of an IoT based smart mirror. Every morning our day begins by watching ourselves at least once in mirror before leaving our homes. We interact with it psychologically to find out how we look and how our attire is. Smart Mirror or Magic Mirror is one of the applications of Raspberry Pie. A computer screen embedded in mirror looks very futuristic. The Raspberry Pie stays at back scenes and controls the data displayed on mirror. While looking at mirror you can look at various notifications from social sites as well news, weather forecast and more things. Such mirrors can be programmed to work as AI and control home appliances by voice input or touch screen. The Raspberry Pie is connected to monitor via HDMI as well as it also has inbuilt Wi-Fi and Bluetooth interfaces so we can just swipe music and videos to mirror.
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43

Kim, Bo-Ram, Hyun Mi Kim, Chang Hyun Jin, Si-Yong Kang, Jin-Baek Kim, Yeo Gyeong Jeon, Kong Young Park, Ik-Soo Lee, and Ah-Reum Han. "Composition and Antioxidant Activities of Volatile Organic Compounds in Radiation-Bred Coreopsis Cultivars." Plants 9, no. 6 (June 4, 2020): 717. http://dx.doi.org/10.3390/plants9060717.

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Coreopsis is a flowering plant belonging to the Asteraceae family. It is an ornamental plant native to the Americas, Asia and Oceania and its flower is used as a raw material for tea and food manufacture in China. In this study, new cultivars of C. rosea (“golden ring”) were developed via radiation-induced mutation of the original cultivar, “pumpkin pie”. The chemical composition and antioxidant activities of flowers belonging to three different Coreopsis cultivars were evaluated: “golden ring”, “pumpkin pie” and “snow chrysanthemum” (coreopsis tea; C. tinctoria). The volatile compounds were characterized via gas chromatography-mass spectrometry (GC-MS) and 50–59 oils representing 95.3–96.8% of the total volatile compounds in these flower materials were identified. ”Golden ring” contained a high amount of fatty acids (38.13%), while “pumpkin pie” and “snow chrysanthemum” teas were rich in aliphatic amides (43.01%) and esters (67.22%), respectively. The antioxidant activities of the volatile oils of these cultivars were evaluated using 1,1-diphenyl-2-picrylhydraxyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. The volatile extract of “golden ring” showed higher antioxidant activities compared with the extracts of the other cultivars. Therefore, “golden ring” can be used for further development as a raw material for tea manufacture or as a dietary supplement.
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Akimova, Yu I. "VIIIth Congress with international participation «Development of pharmacoeconomic s and pharmacoepidemiology in the Russian Federation." Pharmacoeconomics: theory and practice 2, no. 2 (June 15, 2014): 7–10. http://dx.doi.org/10.30809/phe.2.2014.6.

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45

Karasu-Minareci, Edibe, Irem Hicran Ozbudak, Gulay Ozbilim, and Gulay Sadan. "Acute Effects of Vardenafil on Pulmonary Artery Responsiveness in Pulmonary Hypertension." Scientific World Journal 2012 (2012): 1–6. http://dx.doi.org/10.1100/2012/718279.

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Phosphodiesterase type-5 (PDE-5) inhibitors are novel and important options for the treatment of pulmonary arterial hypertension (PAH). Therefore, we aimed to examine effects of vardenafil, a PDE-5 inhibitor, on the pulmonary arteries isolated from rats with monocrotaline- (MCT-) induced pulmonary hypertension. MCT (60 mg/kg) or its vehicle was administered by a single intraperitoneal injection to 6-week-old male Sprague Dawley rats. Rats were sacrificed 21 days after MCT injection, and the main pulmonary arteries were isolated and then mounted in 20 mL organ baths. Concentration-response curves for vardenafil (10−10–10−5 M) were constructed in phenylephrine- (Phe-) precontracted rings. PAH caused marked rightward shift in the curves to vardenafil whereas maximal responses were not affected. Inhibition of NO synthase (L-NAME, 10−4 M) or guanylyl cyclase (ODQ, 10−5 M) caused similar attenuation in responses evoked by vardenafil. Moreover, contraction responses induced by CaCl2(3×10−5–3×10−2 M) were significantly reduced in concentration-dependent manner by vardenafil. In conclusion, vardenafil induced pulmonary vasodilatation via inhibition of extracellular calcium entry in addition to NO-cGMP pathway activation. These results provide evidence that impaired arterial relaxation in PAH can be prevented by vardenafil. Thus, vardenafil represents a valuable therapeutic approach in PAH besides other PDE-5 inhibitors.
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Yuan, Yige, Bingbing Xu, Bo Lin, Liang Hou, Fei Sun, Huawei Shen, and Xueqi Cheng. "PDE+: Enhancing Generalization via PDE with Adaptive Distributional Diffusion." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 15 (March 24, 2024): 16614–22. http://dx.doi.org/10.1609/aaai.v38i15.29600.

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The generalization of neural networks is a central challenge in machine learning, especially concerning the performance under distributions that differ from training ones. Current methods, mainly based on the data-driven paradigm such as data augmentation, adversarial training, and noise injection, may encounter limited generalization due to model non-smoothness. In this paper, we propose to investigate generalization from a Partial Differential Equation (PDE) perspective, aiming to enhance it directly through the underlying function of neural networks, rather than focusing on adjusting input data. Specifically, we first establish the connection between neural network generalization and the smoothness of the solution to a specific PDE, namely transport equation. Building upon this, we propose a general framework that introduces adaptive distributional diffusion into transport equation to enhance the smoothness of its solution, thereby improving generalization. In the context of neural networks, we put this theoretical framework into practice as PDE+ (PDE with Adaptive Distributional Diffusion) which diffuses each sample into a distribution covering semantically similar inputs. This enables better coverage of potentially unobserved distributions in training, thus improving generalization beyond merely data-driven methods. The effectiveness of PDE+ is validated through extensive experimental settings, demonstrating its superior performance compared to state-of-the-art methods. Our code is available at https://github.com/yuanyige/pde-add.
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H. Mohamed, Ahmed, Helmy M. El Zoghby, Mohiy Bahgat, and A. M. Abdel Ghany. "Relativ Relative Rate Obser e Rate Observer Self-T er Self-Tuning of F uning of Fuzzy PID Vir uzzy PID Virtual Iner tual Inertia Control for An Islanded microgrid." Future Engineering Journal 3, no. 2 (November 30, 2022): 1–15. http://dx.doi.org/10.54623/fue.fej.3.2.1.

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Expanding the usage of renewable energy in islanded microgrids leads to a reduction in its total inertia. Low inertia microgrids have difficulties in voltage and frequency control. That affected saving its stability and preventing a blackout. To improve low inertia islanded microgrids' dynamic response and save their stability, this paper presented relative rate observer self-tuning fuzzy PID (RROSTF-PID) based on virtual inertia control (VIC) for an islanded microgrid with a high renewable energy sources (RESs) contribution. RROSTF-PID based on VIC's success in showing remarkable improvement in the microgrid's dynamic response and enhancement of its stability. Moreover, it handles different contingency conditions successfully by giving the desired frequency support. Ant colony optimization (ACO) technique is used to find the optimal values of the RROSTF-PID based on VIC parameters. Furthermore, using MATLAB TM/Simulink, RROSTF-PID based on VIC response is compared to Optimal Fuzzy PID (OF-PID) based VIC, Fuzzy PID (F-PID) based VIC, PID-based VIC, conventional VIC responses, and the microgrid without VIC response under different operation conditions.
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Wu, Yunyu, Yu Chen, Cunhong Pan, Ning Xiao, Ling Yu, Yuhong Li, Xiaoxiang Zhang, et al. "Development and Evaluation of Near-Isogenic Lines with Different Blast Resistance Alleles at the Piz Locus in japonica Rice from the Lower Region of the Yangtze River, China." Plant Disease 101, no. 7 (July 2017): 1283–91. http://dx.doi.org/10.1094/pdis-12-16-1855-re.

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Rice blast, caused by Magnaporthe oryzae, threatens rice production in most of the rice-growing areas in China, especially in regions that have grown Oryza sativa subsp. japonica in recent years. The use of resistance genes is the most effective and economical approach for blast control. In our study, a set of six near-isogenic lines (NIL) were developed by introgression of six resistance alleles of the Piz locus (Pi2, Pigm, Pi40, Pi9, Piz, and Pizt) into a blast-susceptible, high-yielding, high-quality japonica ‘07GY31’ via marker-assisted backcross breeding. Artificial inoculation using 144 M. oryzae isolates collected from the lower region of the Yangtze River, China, revealed that most of the NIL, including NIL-Pi2, NIL-Pigm, NIL-Pi40, NIL-Pi9, and NIL-Pizt, exhibited broad-spectrum resistance against rice blast at the seedling stage, with resistance frequencies (RF) of 93.06 to 98.61%. NIL-Piz was an exception, with an RF of 21.53%, which was slightly higher than the recurrent parent 07GY31. NIL-Pi40 and NIL-Pigm had broad-spectrum resistance (RF of 93.33 and 71.67%, respectively) at the heading stage following inoculation of 60 isolates of M. oryzae. Field trials with artificial inoculation at the seedling and heading stage showed that NIL-Pigm and NIL-Pi40 were highly resistant in four locations under high disease pressure. NIL-Pizt showed effective resistance in three locations from Zhejiang and Jiangsu Provinces. This study shows that O. sativa subsp. japonica alleles of the Piz locus confer resistance to M. oryzae, and provides an effective method to enhance seedling and panicle blast resistance in rice plants in the lower region of the Yangtze River, China.
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49

Miura, Katsushi, and Donald W. MacGlashan. "Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils." Blood 96, no. 6 (September 15, 2000): 2199–205. http://dx.doi.org/10.1182/blood.v96.6.2199.

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Abstract Cross-linking of IgE or a bacterial product (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils. However, the signaling mechanisms in human basophils are only partially understood. It has been demonstrated that extracellular signal-regulated kinases (ERK1/2) specifically regulate the pathway for LTC4 generation, but not for histamine release and interleukin-4 production. More recent studies have suggested that tyrosine kinase (syk)-mediated phosphorylation of shc is responsible for the ras-ERK cascade via the formation of shc-Grb2-Sos2 following stimulation with anti-IgE antibody, but not FMLP, in human basophils. However, while characterizing the role of phosphatidylinositol (PI)-3 kinase in signaling pathways leading to basophil mediator release, it was noted that this pathway might also regulate p21ras activation. Anti-IgE antibody, but not FMLP, resulted in phosphorylation of p85 (regulatory subunit of PI3 kinase), suggesting activation of PI3 kinase. Inhibition of PI3 kinase by selective inhibitor (LY294002) abolished anti-IgE antibody- but not FMLP-induced phosphorylation of MEK1 (MAPK kinase/ERK kinase) and ERKs while inhibiting LTC4 generation as well as histamine release. IgE-mediated activation of ras (upstream of MEK-ERK) was also inhibited. But, further upstream, phosphorylation of syk and of shc and inducible association between shc and Grb2 were not affected. Furthermore, the IgE-mediated cytosolic calcium response ([Ca++]i) was also diminished. These results suggest that functional responses may be dependent on the activity of PI3 kinase, which regulates at least 2 important signaling pathways: by regulating activation of ras for the MEK-ERK pathway and the increase in [Ca++]i.
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50

Miura, Katsushi, and Donald W. MacGlashan. "Phosphatidylinositol-3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils." Blood 96, no. 6 (September 15, 2000): 2199–205. http://dx.doi.org/10.1182/blood.v96.6.2199.h8002199_2199_2205.

Full text
Abstract:
Cross-linking of IgE or a bacterial product (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils. However, the signaling mechanisms in human basophils are only partially understood. It has been demonstrated that extracellular signal-regulated kinases (ERK1/2) specifically regulate the pathway for LTC4 generation, but not for histamine release and interleukin-4 production. More recent studies have suggested that tyrosine kinase (syk)-mediated phosphorylation of shc is responsible for the ras-ERK cascade via the formation of shc-Grb2-Sos2 following stimulation with anti-IgE antibody, but not FMLP, in human basophils. However, while characterizing the role of phosphatidylinositol (PI)-3 kinase in signaling pathways leading to basophil mediator release, it was noted that this pathway might also regulate p21ras activation. Anti-IgE antibody, but not FMLP, resulted in phosphorylation of p85 (regulatory subunit of PI3 kinase), suggesting activation of PI3 kinase. Inhibition of PI3 kinase by selective inhibitor (LY294002) abolished anti-IgE antibody- but not FMLP-induced phosphorylation of MEK1 (MAPK kinase/ERK kinase) and ERKs while inhibiting LTC4 generation as well as histamine release. IgE-mediated activation of ras (upstream of MEK-ERK) was also inhibited. But, further upstream, phosphorylation of syk and of shc and inducible association between shc and Grb2 were not affected. Furthermore, the IgE-mediated cytosolic calcium response ([Ca++]i) was also diminished. These results suggest that functional responses may be dependent on the activity of PI3 kinase, which regulates at least 2 important signaling pathways: by regulating activation of ras for the MEK-ERK pathway and the increase in [Ca++]i.
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