Academic literature on the topic 'Picropodophylline'
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Journal articles on the topic "Picropodophylline":
Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel, and Claude Monneret. "Synthesis of picropodophyllin homolactone." Tetrahedron Letters 41, no. 35 (August 2000): 6769–73. http://dx.doi.org/10.1016/s0040-4039(00)01136-9.
Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel, and Claude Monneret. "ChemInform Abstract: Synthesis of Picropodophyllin Homolactone." ChemInform 31, no. 45 (November 7, 2000): no. http://dx.doi.org/10.1002/chin.200045231.
Wen, Pu Hong. "Kinetic Investigation of Thermal Decomposition Reactions of Podophyllic Acid and Picropodophyllic Acid." Advanced Materials Research 391-392 (December 2011): 1230–34. http://dx.doi.org/10.4028/www.scientific.net/amr.391-392.1230.
Guo, Hong Zhu, De An Guo, Xue Yan Fei, Ya Jun Cui, and Jun Hua Zheng. "Biotransformation of Podophyllotoxin to Picropodophyllin by Microbes." Journal of Asian Natural Products Research 1, no. 2 (December 1998): 99–102. http://dx.doi.org/10.1080/10286029808039850.
Ohshima-Hosoyama, Sachiko, Tohru Hosoyama, Laura D. Nelon, and Charles Keller. "IGF-1 receptor inhibition by picropodophyllin in medulloblastoma." Biochemical and Biophysical Research Communications 399, no. 4 (September 2010): 727–32. http://dx.doi.org/10.1016/j.bbrc.2010.08.009.
Wu, Qi, Ai-Ling Tian, Guido Kroemer, and Oliver Kepp. "Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib." Autophagy 17, no. 8 (June 10, 2021): 2046–47. http://dx.doi.org/10.1080/15548627.2021.1936934.
Berkowitz, David B., Sungjo Choi, and Jun-Ho Maeng. "Enzyme-Assisted Asymmetric Total Synthesis of (−)-Podophyllotoxin and (−)-Picropodophyllin." Journal of Organic Chemistry 65, no. 3 (February 2000): 847–60. http://dx.doi.org/10.1021/jo991582+.
Pohmakotr, Manat, Taweechote Komutkul, Patoomratana Tuchinda, Samrarn Prabpai, Palangpon Kongsaeree, and Vichai Reutrakul. "Syntheses of (±)-thuriferic acid ethyl ester, its analogues and (±)-picropodophyllone." Tetrahedron 61, no. 22 (May 2005): 5311–21. http://dx.doi.org/10.1016/j.tet.2005.03.069.
Pullin, Robert D. C., Jonathan D. Sellars, and Patrick G. Steel. "Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin." Organic & Biomolecular Chemistry 5, no. 19 (2007): 3201. http://dx.doi.org/10.1039/b710370k.
Colón, Eugenia, Farasat Zaman, Magnus Axelson, Olle Larsson, Christine Carlsson-Skwirut, Konstantin V. Svechnikov, and Olle Söder. "Insulin-Like Growth Factor-I Is an Important Antiapoptotic Factor for Rat Leydig Cells during Postnatal Development." Endocrinology 148, no. 1 (January 1, 2007): 128–39. http://dx.doi.org/10.1210/en.2006-0835.
Dissertations / Theses on the topic "Picropodophylline":
Zhao, Rathje Li-Sophie. "Tropomyosin in Normal and Malignant Cells and the Action of Picropodophyllin on the Microfilament and Microtubule Systems." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27767.
Larsson, Patrik. "Inhibiting the IGF-1 receptor with the cyclolignan Picropodophyllin: an in vitro study of ovulation, implantation and receptivity in a mouse model." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89109.
Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected. PCR-primers for cDNA sequences of estrogene receptor α, estrogene receptor β, progesterone receptor A, progesterone receptor B, growth hormone receptor, interleukin 1 α, interleukin 1 β, tumour necrosis factor α and androgen receptor were used. Real Time PCR was run with the samples and gene expression was measured. The results of this study showed that the inhibition of IGF-1 receptor interacted with IGF-1 which lead to altered levels of estrogene receptor alpha, progesterone receptor, growth hormone receptor and androgen receptor that can decrease ovulation. The results also showed the differences in gene products between treated and untreated samples, suggesting that IGF-1 plays an important role regarding ovulation.
Studier med hjälp av den selektiva insulinlika tillväxtfaktor 1 receptorn (IGF-1R) antagonisten; picropodof?phyllin (PPP), hur samspelet mellan livmoderslemhinnan och implantationsprocessen, samt hur ovulationen påverkas av insulinlika tillväxtfaktorn 1 (IGF-1) kan nu utföras. IGF-1 tros ha en viktig roll för den reproduktiva processen, där den påverkar ovulation, implantation och embryoutveckling. IGF-familjen består av tre ligander; insulin, IGF-1 och IGF-2. IGF transporteras bundet till bindarprotein (IGFBP). Medlemmarna i IGF receptorfamiljen kan binda IGF-1, IGF-2 och insulin fast med olika affinitet. PPP som är en cykloligan, är en analog från podofyllotoxin och fungerar som en syntetisk IGF-1 receptorantagonist, som selektivt inhiberar receptorns aktivitet. PPP tros även kunna nedreglera genexpression av receptorn. Tre tidigare projektarbeten har utförts på vävnader från möss injicerade med PPP. Tyngdpunkterna i dessa arbeten har legat på immunhistokemiska studier av IGF-1 i reproduktionsorgan från möss, uttryck av IGF-1, dess receptor och bindarprotein 1 i ovarier och uterus efter behandling med PPP. I denna studie användes vävnad samt cDNA från sju möss behandlade med PPP, i olika stadier av reproduktionen samt även icke behandlade möss. Studiens syfte var att med sanntids-PCR jämföra genuttryck från östrogenreceptor α och β, progesteronreceptor A och B, tillväxthormonreceptor, Interleukin 1 α och β, ’tumor necrosis’ faktor α samt androgenreceptor i vävnad från PPP-behandlade och obehandlade möss och genom de erhållna resultaten från ovarievävnaden utläsa effekten på ovulationen och från uterusvävnaden effekten på implantation och receptivitet. Studieresultaten visade att IGF-1s frånvaro gav förändrade nivåer av genprodukter, som medförde minskad ovulationen. Studien visade att IGF-1s roll vid ovulationen var väsentlig.
Delforoush, Maryam. "Potential New Drugs in Lymphoma." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546.
Conference papers on the topic "Picropodophylline":
Wong Te Fong, Anne-Christine LF, Chris Jones, John R. Griffiths, Martin O. Leach, and Yuen-Li Chung. "Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5640.