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Journal articles on the topic 'Physicochemical and biological properties'

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Author: Grafiati

Published: 30 May 2022

Last updated: 31 May 2022

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1

Rachkovskaya, L. N., T. V. Popova, A. Yu Letyagin, T. G. Tolstikova, M. A. Korolyov, N. Bogdanchikova, A. N. Pestryakov, A. A. Kotlyarova, V. Burmistrov, and V. I. Konenkov. "Silver containing sorbents: Physicochemical and biological properties." Resource-Efficient Technologies 2, no. 2 (June 2016): 43–49. http://dx.doi.org/10.1016/j.reffit.2016.06.001.

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2

Parkhomenko, N. I., L. A. Maksymenko, and L. F. Didenko. "Biological and physicochemical properties of cymbidium mosaic virus." Reports of the National Academy of Sciences of Ukraine, no. 10 (October 2020): 71–76. http://dx.doi.org/10.15407/dopovidi2020.10.071.

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The isolated cymbidium mosaic virus (CMV) is one of the most wide-spread and dangerous pathogens that infects promising varieties of orchids. It causes characteristic symptoms on orchid plants, which are manifested in the form of a mosaic. Over time, these areas are necrotized, leading to the stop of flowering the plants and reducing their decorative value. The CyMV is not spread by insects-carriers, but is transmitted by the mechanical inoculation with juice. Electron microscopy revealed flexible filamentous viral particles with a length of about 500 nm. The purified viral preparation is sedimented with a single peak with a sedimentation coefficient of 142S. The floating density of the virus in the preformed CsCl gradient corresponded to 1.3 g/cm3. The electrophoretic analysis of proteins in polyacrylamide gel under denatured conditions showed the presence of two polypeptides with molecular weights of 27 and 31 kDa. RNA CyMV has a molecular weight of 2 · 106 Da. In the translation system of rabbit reticulocytes in vitro, a protein with a molecular weight of about 27 kDa is synthesized. The obtained data allow us to refer CyMV to the group of potexviruses.

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3

Yoo, Sang-Ho, Kyung Hee Lee, Ji-Soo Lee, Jaeho Cha, Cheon Seok Park, and Hyeon Gyu Lee. "Physicochemical Properties and Biological Activities of DEAE-DerivatizedSphingomonasGellan." Journal of Agricultural and Food Chemistry 53, no. 16 (August 2005): 6235–39. http://dx.doi.org/10.1021/jf050018z.

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4

Iwahara, Junji, Alexandre Esadze, and Levani Zandarashvili. "Physicochemical Properties of Ion Pairs of Biological Macromolecules." Biomolecules 5, no. 4 (September 30, 2015): 2435–63. http://dx.doi.org/10.3390/biom5042435.

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5

Imbach, Jean-Louis, Bernard Rayner, and François Morvan. "Sugar-Modified Oligonucleotides: Synthesis, Physicochemical and Biological Properties." Nucleosides, Nucleotides and Nucleic Acids 8, no. 5 (1989): 627–48. http://dx.doi.org/10.1080/07328318908054204.

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6

Rahmati, Maryam, Eduardo A. Silva, Janne E. Reseland, Catherine A. Heyward, and Håvard J. Haugen. "Biological responses to physicochemical properties of biomaterial surface." Chemical Society Reviews 49, no. 15 (2020): 5178–224. http://dx.doi.org/10.1039/d0cs00103a.

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7

Oyesomi, Opeyemi O., Ayobami O. Oyedele, Idris A. Oyemitan, Oluwole I. Adeyem, and Anthony A. Elujoba. "Aloe schweinfurthii gel: composition physicochemical and biological properties." International Journal of Complementary & Alternative Medicine 14, no. 1 (February 16, 2021): 26–33. http://dx.doi.org/10.15406/ijcam.2021.14.00529.

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8

Koloskova, Olesya O., Uliana A. Budanova, Inga C. Shchelik, Igor P. Shilovskii, Musa R. Khaitov, and Yurii L. Sebyakin. "Examination the Properties of Lipopeptide Liposomes Modified by Glycoconjugates." Nano Hybrids and Composites 13 (January 2017): 82–88. http://dx.doi.org/10.4028/www.scientific.net/nhc.13.82.

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Development of transport systems possessing definite physicochemical and biological properties aimed at the targeted delivery of biologically active compounds remains nowadays among urgent problems of the medicine. In this work we made physical chemical and biological tests liposomal drug delivery systems modified with glycolipids for target properties.

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9

Aguirre-Ramírez, M., H. Silva-Jiménez, I. M. Banat, and M. A. Díaz De Rienzo. "Surfactants: physicochemical interactions with biological macromolecules." Biotechnology Letters 43, no. 3 (February 3, 2021): 523–35. http://dx.doi.org/10.1007/s10529-020-03054-1.

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AbstractMacromolecules are essential cellular components in biological systems responsible for performing a large number of functions that are necessary for growth and perseverance of living organisms. Proteins, lipids and carbohydrates are three major classes of biological macromolecules. To predict the structure, function, and behaviour of any cluster of macromolecules, it is necessary to understand the interaction between them and other components through basic principles of chemistry and physics. An important number of macromolecules are present in mixtures with surfactants, where a combination of hydrophobic and electrostatic interactions is responsible for the specific properties of any solution. It has been demonstrated that surfactants can help the formation of helices in some proteins thereby promoting protein structure formation. On the other hand, there is extensive research towards the use of surfactants to solubilize drugs and pharmaceuticals; therefore, it is evident that the interaction between surfactants with macromolecules is important for many applications which includes environmental processes and the pharmaceutical industry. In this review, we describe the properties of different types of surfactants that are relevant for their physicochemical interactions with biological macromolecules, from macromolecules–surfactant complexes to hydrophobic and electrostatic interactions.

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10

Gooden, David, Harinath Chakrapani, and Eric Toone. "C-Nitroso Compounds: Synthesis, Physicochemical Properties and Biological Activities." Current Topics in Medicinal Chemistry 5, no. 7 (July 1, 2005): 687–705. http://dx.doi.org/10.2174/1568026054679353.

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11

Popovic-Djordjevic, Jelena, Vesna Vitnik, Zeljko Vitnik, and Milovan Ivanovic. "Glutarimides: Biological activity, general synthetic methods and physicochemical properties." Chemical Industry 69, no. 5 (2015): 523–36. http://dx.doi.org/10.2298/hemind140701073p.

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Glutarimides, 2,6-dioxopiperidines are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics. Glutarimides act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antibacterials, and tumor suppressing agents. Some synthetic glutarimide derivatives are already in use as immunosuppressive and sedative (e.g., thalidomide) or anxiolytics (buspirone) drugs. The wide applicability of this class of compounds, justify the interest of scientists to explore new pathways for its syntheses. General methods for synthesis of six-membered imide ring, are presented in this paper. These methods include: a) reaction of dicarboxylic acids with ammonia or primary amine, b) reactions of cyclization: amido-acids, diamides, dinitriles, nitrilo-acids, amido-nitriles, amido-esters, amidoacyl-chlorides or diacyl-chlorides, c) adition of carbon-monoxide on a,b-unsaturated amides, d) oxidation reactions, e) Michael adition of active methylen compounds on methacrylamide or conjugated amides. Some of the described methods are used for closing glutarimide ring in syntheses of farmacological active compounds sesbanimide and aldose reductase inhibitors (ARI). Analyses of the geometry, as well as, the spectroscopic analyses (NMR and FT-IR) of some glutarimides are presented because of their broad spectrum of pharmacological activity. To elucidate structures of glutarimides, geometrical parameters of newly synthesized tert-pentyl-1-benzyl-4-methyl-glutarimide-3-carboxylate (PBMG) are analyzed and compared with the experimental data from X-ray analysis for glutarimide. Moreover, molecular electrostatic potential (MEP) surface which is plotted over the optimized geometry to elucidate the reactivity of PBMG molecule is analyzed. The electronic properties of glutarimide derivatives are explained on the example of thalidomide. The Frontier Molecular Orbital (FMO) and their energies are presented, as well as the energy gap between them.

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12

Won, Ran. "Physicochemical and Biological Properties of Polysaccharide Derived from Insects." Journal of Chitin and Chitosan 24, no. 2 (June 30, 2019): 124–31. http://dx.doi.org/10.17642/jcc.24.2.8.

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13

Guo, Huijing, Weida Zhang, Ying Jiang, Hai Wang, Guogang Chen, and Minrui Guo. "Physicochemical, Structural, and Biological Properties of Polysaccharides from Dandelion." Molecules 24, no. 8 (April 15, 2019): 1485. http://dx.doi.org/10.3390/molecules24081485.

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The edible and medicinal perennial herb dandelion is known to have antitumor, antioxidant, and anticomplement properties. However, the structural characterization and biological effects of its polysaccharides are not well understood. Here, we aimed to extract and investigate a novel polysaccharide from dandelion. A water-soluble polysaccharide, PD1-1, was successfully obtained from dandelion through ultrasonic-assisted extraction and purification using diethylaminoethyl (DEAE)–Sepharose fast flow and Sephadex G-75 columns. The results showed that PD1-1 is an inulin-type polysaccharide with a molecular weight of 2.6 kDa and is composed of glucose (52.39%), and mannose (45.41%). Glycosidic linkage analysis demonstrated that PD1-1 contains terminal α-d-Man/Glcp-(1→ and →1)-β-d-Man/Glcf-(2→ glycosidic linkage conformations. A physicochemical analysis indicated that PD1-1 has a triple helix structure and exhibits important properties, including good swelling, water-holding, and oil-holding capacities. Furthermore, PD1-1 showed good antioxidant activities in DPPH and hydroxyl free radical scavenging abilities, with IC50 values of 0.23 mg/mL and 0.25 mg/mL, respectively, and good hypoglycemic activities in α-amylase and α-glucosidase inhibition, with IC50 values of 0.53 mg/mL and 0.40 mg/mL, respectively, in a concentration-dependent manner. Results suggest that PD1-1 possesses efficacious antioxidant and hypoglycemic properties and has potential applications as a functional food ingredient.

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Radhouani, Hajer, Cristiana Gonçalves, Fátima R. Maia, Joaquim M. Oliveira, and Rui L. Reis. "Kefiran biopolymer: Evaluation of its physicochemical and biological properties." Journal of Bioactive and Compatible Polymers 33, no. 5 (August 18, 2018): 461–78. http://dx.doi.org/10.1177/0883911518793914.

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Kefiran, an exopolysaccharide produced by lactic acid bacteria, has received a great interest due to a variety of health claims. In this study, we aim to investigate the physicochemical and biological properties of Kefiran polysaccharide extracted from Portuguese kefir grains. The kefir growth rate was about 56% (w/w) at room temperature and the kefir pH after 24 h was about 4.6. The obtained yield of Kefiran polysaccharide extracted from the kefir grains was about 4.26% (w/w). The Kefiran structural features were showed in the 1H nuclear magnetic resonance spectrum. The bands observed in the infrared spectrum confirmed that the Kefiran had a β-configuration; and the X-ray photoelectron spectroscopy analysis confirmed the structure and composition of Kefiran and revealed a C/O atomic ratio of 1.46. Moreover, Kefiran showed an average molecular weight (Mw) of 534 kDa and a number-average molecular weight (Mn) of 357 kDa. Regarding the rheological data obtained, Kefiran showed an interesting adhesive performance accompanied by a pseudoplastic behavior, and the extrusion force of Kefiran was 1 N. Furthermore, Kefiran exhibited a higher resistance to hyaluronidase degradation than hyaluronic acid. Finally, Kefiran showed a lack of cytotoxic response through its ability to support metabolic activity and proliferation of L929 cells, and had no effect on these cells’ morphology. Our research suggested that Kefiran polymer has attractive and interesting properties for a wide range of biomedical applications, such as tissue engineering and regenerative medicine.

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15

Borodulin, V. B., A. D. Matasov, I. A. Goroshinskaya, I. S. Okunev, S. N. Petrov, N. F. Drozdova, P. S. Kachesova, et al. "PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES OF ASSOCIATES OF COPPER NANOPARTICLES." Nanotechnologies in Russia 14, no. 1-2 (January 2019): 74–81. http://dx.doi.org/10.1134/s1995078019010038.

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16

Liegéois, Jean-François, Georges Dive, Léon Dupont, and Jacques Delarge. "New Alkoxypyridine-sulfonamides: Synthesis, Biological Evaluation, and Physicochemical Properties." Helvetica Chimica Acta 74, no. 8 (December 11, 1991): 1764–72. http://dx.doi.org/10.1002/hlca.19910740819.

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17

Daroit, Daniel J., Ana Paula F. Corrêa, Manuel Mancilla Canales, Julise G. Coelho, María E. Hidalgo, Deise M. Tichota, Patricia H. Risso, and Adriano Brandelli. "Physicochemical properties and biological activities of ovine caseinate hydrolysates." Dairy Science & Technology 92, no. 4 (June 8, 2012): 335–51. http://dx.doi.org/10.1007/s13594-012-0068-3.

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18

Szunyogová, Erika, Dagmar Mudroňová, Katarína Györyová, Radomíra Nemcová, Jana Kovářová, and Lenka Piknová-Findoráková. "The physicochemical and biological properties of zinc(II) complexes." Journal of Thermal Analysis and Calorimetry 88, no. 2 (May 2007): 355–61. http://dx.doi.org/10.1007/s10973-006-8115-z.

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19

Pyanova, L. G., V. A. Drozdov, N. V. Kornienko, M. V. Trenikhin, and A. V. Lavrenov. "Physicochemical and Medical–Biological Properties of Carbon Sorbents Modified by Biologically Active Substances." Protection of Metals and Physical Chemistry of Surfaces 57, no. 6 (November 2021): 1122–28. http://dx.doi.org/10.1134/s207020512105021x.

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20

Mohd Kamal, Datu Agasi, Siti Fatimah Ibrahim, Haziq Kamal, Mohd Izhar Ariff Mohd Kashim, and Mohd Helmy Mokhtar. "Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review." Nutrients 13, no. 1 (January 10, 2021): 197. http://dx.doi.org/10.3390/nu13010197.

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Tualang, Gelam and Kelulut honeys are tropical rainforest honeys reported to have various medicinal properties. Studies related to the medicinal properties and physicochemical characteristics of these honeys are growing extensively and receiving increased attention. This review incorporated and analysed the findings on the biological and physicochemical properties of these honeys. Tualang, Gelam and Kelulut honeys were found to possess a wide variety of biological effects attributed to their physicochemical characteristics. Findings revealed that these honeys have anti-diabetic, anti-obesity, anti-cancer, anti-oxidative, anti-microbial, anti-inflammatory and wound-healing properties and effects on the cardiovascular system, nervous system and reproductive system. The physicochemical properties of these honeys were compared and discussed and results showed that they have high-quality contents and excellent antioxidant sources.

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Mohd Kamal, Datu Agasi, Siti Fatimah Ibrahim, Haziq Kamal, Mohd Izhar Ariff Mohd Kashim, and Mohd Helmy Mokhtar. "Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review." Nutrients 13, no. 1 (January 10, 2021): 197. http://dx.doi.org/10.3390/nu13010197.

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Tualang, Gelam and Kelulut honeys are tropical rainforest honeys reported to have various medicinal properties. Studies related to the medicinal properties and physicochemical characteristics of these honeys are growing extensively and receiving increased attention. This review incorporated and analysed the findings on the biological and physicochemical properties of these honeys. Tualang, Gelam and Kelulut honeys were found to possess a wide variety of biological effects attributed to their physicochemical characteristics. Findings revealed that these honeys have anti-diabetic, anti-obesity, anti-cancer, anti-oxidative, anti-microbial, anti-inflammatory and wound-healing properties and effects on the cardiovascular system, nervous system and reproductive system. The physicochemical properties of these honeys were compared and discussed and results showed that they have high-quality contents and excellent antioxidant sources.

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22

Pj, Jainey, and Ishwar Bhat K. "SYNTHESIS, IN SILICO PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES OF SOME PYRAZOLINE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (April 1, 2017): 456. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.17093.

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Objectives: Nitrogen containing heterocyclic compounds plays an important role in medicinal chemistry. Among them, five-membered ring pyrazolines have found to possess many biological and pharmacological activities like anticancer, antitubercular, antimicrobial, anti-inflammatory etc. Objective is to determine the physicochemical and drug like properties of the synthesized pyrazolines by in silico methods and to screen their antidiabetic and antioxidant activities.Methods: Chalcones were synthesized from naphthaldehydes by condensing with various substituted acetophenones in ethanol and cyclized into pyrazolines using semicarbazides/thiosemicarbazides by conventional and microwave oven synthesis. The physicochemical and drug like properties were determined by using computational tools. Antidiabetic activity was evaluated by alpha amylase inhibition assay method. Antioxidant activity studies were done by DPPH and nitric oxide method.Results: Pyrazolines were synthesized from chalcones. Microwave irradiated synthesis of chalcone was carried out to get higher yield with less reaction time period as compared to conventional method. The synthesized pyrazolines produces yield around 68% (conventional) and 85% (microwave). In silico studies showed considerable values satisfying all the parameters of physicochemical and Lipinski’s rule of five properties. Among the compounds tested for antidiabetic and antioxidant studies, some showed promising activity.Conclusion: Physiochemical and drug like properties revealed that these compounds have good bioavailability and druglikeness properties. So these compounds are found to be interesting lead molecules for further synthesis as antidiabetic and antioxidant agents.Keywords: Chalcones, pyrazolines, in silico physicochemical properties, biological activities.

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23

Gossard, Alban, Fabien Frances, Camille Aloin, Clara Penavayre, Nicolas Fabrègue, and Célia Lepeytre. "Effect of Surfactant Concentration on the Long-Term Properties of a Colloidal Chemical, Biological and Radiological (CBR) Decontamination Gel." Fluids 6, no. 11 (November 12, 2021): 410. http://dx.doi.org/10.3390/fluids6110410.

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Chemically, biologically, or radiologically contaminated surfaces can be treated using colloidal “vacuumable” gels containing alumina particles as a thickening agent, decontaminating solutions to inhibit/eliminate biological and chemical contaminants, and Pluronic PE 6200 as a surfactant to adjust the gel’s physicochemical properties. These gels have been shown to remain efficient even after prolonged storage. In the present study, the properties of gels with different surfactant concentrations were monitored over several months using rheological analyses, contact angle measurements, and ion chromatography. Results show that the surfactant reacts with the hypochlorite ions in the decontaminating solution. This leads to sedimentation, which modifies the rheological properties of the gel. Increasing the surfactant concentration ensures the physicochemical properties of the gel are preserved for longer, but because the surfactant reacts with the hypochlorite ions, the concentration of the latter decreases drastically and thus so do the decontamination properties of the gel. There is therefore a trade-off between the efficiency of the gel against chemical and biological contamination at a given time and how long its physicochemical properties are preserved, with the optimal balance depending on its intended use.

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24

Pajor, Kamil, Lukasz Pajchel, Barbara Kolodziejska, and Joanna Kolmas. "Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance." Crystals 8, no. 5 (April 26, 2018): 188. http://dx.doi.org/10.3390/cryst8050188.

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25

Fujii, Tozo, and Taisuke Itaya. "Five Nc-Methyladenines: Their Chemistry, Physicochemical Properties, and Biological Activities." HETEROCYCLES 48, no. 8 (1998): 1673. http://dx.doi.org/10.3987/rev-98-500.

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Fujii, Tozo, and Taisuke Itaya. "Nx-Oxygenated Adenines: Their Chemistry, Physicochemical Properties, and Biological Activities." HETEROCYCLES 51, no. 8 (1999): 1971. http://dx.doi.org/10.3987/rev-99-521.

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27

Acosta, O. "Some Biological and Physicochemical Properties of Bean Rugose Mosaic Virus." Phytopathology 76, no. 11 (1986): 1182. http://dx.doi.org/10.1094/phyto-76-1182.

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28

LIEGEOIS, J. F., G. DIVE, L. DUPONT, and J. DELARGE. "ChemInform Abstract: New Alkoxypyridinesulfonamides: Synthesis, Biological Evaluation, and Physicochemical Properties." ChemInform 23, no. 11 (August 22, 2010): no. http://dx.doi.org/10.1002/chin.199211175.

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29

Milella, E., P. A. Ramires, E. Brescia, G. La Sala, L. Di Paola, and V. Bruno. "Physicochemical, mechanical, and biological properties of commercial membranes for GTR." Journal of Biomedical Materials Research 58, no. 4 (2001): 427–35. http://dx.doi.org/10.1002/jbm.1038.

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30

Fonseca, Keila B., F. Raquel Maia, Filipe A. Cruz, Douglas Andrade, Maria A. Juliano, Pedro L. Granja, and Cristina C. Barrias. "Enzymatic, physicochemical and biological properties of MMP-sensitive alginate hydrogels." Soft Matter 9, no. 12 (2013): 3283. http://dx.doi.org/10.1039/c3sm27560d.

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31

Mao, Shirui, Xintao Shuai, Florian Unger, Michael Simon, Dianzhou Bi, and Thomas Kissel. "The depolymerization of chitosan: effects on physicochemical and biological properties." International Journal of Pharmaceutics 281, no. 1-2 (August 2004): 45–54. http://dx.doi.org/10.1016/j.ijpharm.2004.05.019.

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32

Inada, Yuji, Takayuki Yoshimoto, Ayako Matsushima, and Yuji Saito. "Engineering physicochemical and biological properties of proteins by chemical modification." Trends in Biotechnology 4, no. 3 (March 1986): 68–73. http://dx.doi.org/10.1016/0167-7799(86)90258-1.

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33

Goncalves, S. E. P., B. M. Fonseca, D. C. Barcellos, B. N. Cavalcanti, T. M. Silva, L. L. Goncalves, S. R. M. S. Esteves, and A. Maselli. "Mechanical, physicochemical and biological properties of experimental EGCG based adhesive." Dental Materials 32 (2016): e84. http://dx.doi.org/10.1016/j.dental.2016.08.175.

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Wilkowska, Agnieszka, Agata Czyżowska, Wojciech Ambroziak, and Janusz Adamiec. "Structural, physicochemical and biological properties of spray-dried wine powders." Food Chemistry 228 (August 2017): 77–84. http://dx.doi.org/10.1016/j.foodchem.2017.01.115.

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35

Poniatowska, Aleksandra, Paulina Anna Trzaskowska, Maciej Trzaskowski, and Tomasz Ciach. "Physicochemical and Biological Properties of Graphene-Oxide-Coated Metallic Materials." Materials 14, no. 19 (October 1, 2021): 5752. http://dx.doi.org/10.3390/ma14195752.

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In this article, we present graphene oxide (produced by a modified Hummers’ method) coatings obtained using two different methods: electrophoretic deposition on 316L stainless steel and chemical modification of the surface of gold applied to the steel. The coating properties were characterized by microscopic and spectrometric techniques. The contact angle was also determined, ranging from 50° to 70°. Our results indicated that GO coatings on steel and gold were not toxic towards L929 cells in a direct cell adhesion test—on all tested materials, it was possible to observe the growth of L929 cells during 48 h of culture. The lack of toxic effect on cells was also confirmed in two viability tests, XTT and MTT. For most of the tested materials, the cell viability was above 70%. They showed that the stability of the coating is the crucial factor for such GO coatings, and prove that GO in the form of coating is non-toxic; however, it can show toxicity if detached from the surface. The obtained materials also did not show any hemolytic properties, as the percentage of hemolysis was on the level of the negative control, which is very promising in the light of future potential applications.

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Peng, Hsin-Hsin, Cheng-Yeu Wu, David Young, Jan Martel, Andrew Young, David M. Ojcius, Yu-Hsiu Lee, and John D. Young. "Physicochemical and Biological Properties of Biomimetic Mineralo-Protein Nanoparticles Formed Spontaneously in Biological Fluids." Small 9, no. 13 (December 16, 2012): 2297–307. http://dx.doi.org/10.1002/smll.201202270.

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37

Yoo, Kyung-Hyeon, Yong-Il Kim, and Seog-Young Yoon. "Physicochemical and Biological Properties of Mg-Doped Calcium Silicate Endodontic Cement." Materials 14, no. 8 (April 8, 2021): 1843. http://dx.doi.org/10.3390/ma14081843.

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Calcium silicate-based cement has been widely used for endodontic repair. However, it has a long setting time and needs to shorten setting time. This study investigated the effects of magnesium (Mg) ion on the setting reaction, mechanical properties, and biological properties of calcium silicate cement (CSC). Sol-gel route was used to synthesize Mg ion-doped calcium silicate cement. Synthesized cement was formulated with the addition of different contents of Mg ion, according to 0, 1, 3, 5 mol% of Mg ion-doped calcium silicate. The synthesized cements were characterized with X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). We also evaluated the physicochemical and biological properties of cement, such as the setting time, compressive strength, micro-hardness, simulated body fluid (SBF) immersion, cytotoxicity, and cell differentiation tests. As a result, the Mg ion improves the hydration properties of calcium silicate cement, and the setting time is reduced by increasing the amounts of Mg ion. However, the mechanical properties deteriorated with increasing Mg ion, and 1 and 3 mol% Mg-doped calcium silicate had appropriate mechanical properties. Also, the results of biological properties such as cytotoxicity, ALP activity, and ARS staining improved with Mg ion. Consequently, the optimal condition is 3 mol% of Mg ion-doped calcium silicate (3%Mg-CSC).

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Gupta, Deepak, Deepak Bhatia, Vivek Dave, Vijaykumar Sutariya, and Sheeba Varghese Gupta. "Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations." Molecules 23, no. 7 (July 14, 2018): 1719. http://dx.doi.org/10.3390/molecules23071719.

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The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

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Baláž, Štefan, Ernest Šturdík, Regina Ujhelyová, Dušan Valigura, Michal Uher, Miroslav Veverka, Václav Konečný, Jana Adamcová, Peter Michalík, and Július Brtko. "Biologically Important Physicochemical Properties of Kojic Acid Derivatives." Collection of Czechoslovak Chemical Communications 58, no. 3 (1993): 693–701. http://dx.doi.org/10.1135/cccc19930693.

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Physicochemical properties (hydrophobicity, acidity, metal complexing ability), which are expected to play a role in biological activity of kojic acid derivatives, were determined for 35 compounds. The structure-property relationship were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correlation factors according to Leo and Hansch as well as between acidity and a set of Hammett constants of the varying substituents.

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Rogalewicz, Bartłomiej, Małgorzata Szczesio, Ewa Poleszak, Joanna Kowalczyk, Bernadeta Szewczyk, Bruno Cury Camargo, Jacek Szczytko, et al. "Influence of Incorporation of Different dn-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Properties." International Journal of Molecular Sciences 22, no. 23 (November 29, 2021): 12909. http://dx.doi.org/10.3390/ijms222312909.

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Three new compounds, namely [HL]2+[CuCl4]2−, [HL]2+[ZnCl4]2−, and [HL]2+[CdCl4]2− (where L: imipramine) were synthesized and their physicochemical and biological properties were thoroughly investigated. All three compounds form isostructural, crystalline systems, which have been studied using Single-Crystal X-ray diffraction analysis (SC-XRD) and Fourier-transform infrared spectroscopy (FTIR). The thermal stability was investigated using thermogravimetric analysis (TGA) and melting points for all compounds have been determined. Magnetic measurements were performed in order to study the magnetic properties of the compounds. The above mentioned techniques allowed us to comprehensively examine the physicochemical properties of the newly obtained compounds. The biological activity was investigated using the number of Zebrafish tests, as it is one of the most common models for studying the impact of newly synthesized compounds on the central nervous system (CNS), since this model is very similar to the human CNS.

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Li, Chaofeng, Yun Chen, and Boping Tang. "Physicochemical Properties and Biological Activities of Melanin Extracted from Sunflower Testae." Food Science and Technology Research 24, no. 6 (2018): 1029–38. http://dx.doi.org/10.3136/fstr.24.1029.

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Makni, Mohamed, Raoua Jemai, Walid Kriaa, Yassine Chtourou, and Hamadi Fetoui. "Citrus limon from Tunisia: Phytochemical and Physicochemical Properties and Biological Activities." BioMed Research International 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/6251546.

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Natural plant extracts contain a variety of phenolic compounds which are assigned various biological activities. Our work aims to make a quantitative and qualitative characterization of the Zest (ZL) and the Flesh (FL) of lemon (Citrus limon), to valorize the pharmacological uses of lemon, by evaluating in vitro activities (DPPH, free radical scavenging and reducing power). The antibacterial, antifungal, and antiproliferative activities were sought in the ability of Citrus limon extracts to protect DNA and protein. We found that the ZL contains high amounts of phenolics responsible for the important antioxidant properties of the extract. However, the FL is richer in flavonoids than the ZL. The FL extract was also found to be more effective than the ZL in protecting plasmid DNA against the strand breakage induced by hydroxyl radicals. We also concluded that the FL extract exhibited potent antibacterial activity unlike ZL. Analysis by LC/MS-MS identified 6 compounds (Caffeoyl N-Tryptophan, Hydroxycinnamoyl-Oglucoside acid, Vicenin 2, Eriocitrin, Kaempferol-3-O- rutinoside, and Quercetin-3-rutinoside). These preliminary results showed that Citrus limon has antibacterial and antioxidant activity in vitro. It would be interesting to conduct further studies to evaluate the in vivo potential in an animal model.

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Rebecca, Martin, Wang Hsing-Lin, Gao Jun, Iyer Srinivas, Montaño A. Gabriel, Martinez Jennifer, Shreve P. Andrew, et al. "Impact of physicochemical properties of engineered fullerenes on key biological responses." Toxicology and Applied Pharmacology 234, no. 1 (January 2009): 58–67. http://dx.doi.org/10.1016/j.taap.2008.08.021.

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Zhou, Wei, Teng-Fei Lv, Yong Chen, Anthony P. Westby, and Wan-Jun Ren. "Soil Physicochemical and Biological Properties of Paddy-Upland Rotation: A Review." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/856352.

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Paddy-upland rotation is an unavoidable cropping system for Asia to meet the increasing demand for food. The reduction in grain yields has increased the research interest on the soil properties of rice-based cropping systems. Paddy-upland rotation fields are unique from other wetland or upland soils, because they are associated with frequent cycling between wetting and drying under anaerobic and aerobic conditions; such rotations affect the soil C and N cycles, make the chemical speciation and biological effectiveness of soil nutrient elements varied with seasons, increase the diversity of soil organisms, and make the soil physical properties more difficult to analyze. Consequently, maintaining or improving soil quality at a desirable level has become a complicated issue. Therefore, fully understanding the soil characteristics of paddy-upland rotation is necessary for the sustainable development of the system. In this paper, we offer helpful insight into the effect of rice-upland combinations on the soil chemical, physical, and biological properties, which could provide guidance for reasonable cultivation management measures and contribute to the improvement of soil quality and crop yield.

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Goonoo, Nowsheen, Archana Bhaw-Luximon, and Dhanjay Jhurry. "Biodegradable polymer blends: miscibility, physicochemical properties and biological response of scaffolds." Polymer International 64, no. 10 (June 2, 2015): 1289–302. http://dx.doi.org/10.1002/pi.4937.

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JIN, Hong-Wei, Fang WANG, Yue CHEN, Zhen-Jun YANG, Li-He ZHANG, Ye HUANG, and Liang-Ren ZHANG. "Synthesis, physicochemical and biological properties of oligonucleotides incorporated with amino-isonucleosides." SCIENTIA SINICA Chimica 42, no. 2 (February 1, 2012): 213–14. http://dx.doi.org/10.1360/zb2012-42-2-213.

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Liu, Haohuai, Li Zhang, Jidong Li, Qin Zou, Yi Zuo, Weidong Tian, and Yubao Li. "Physicochemical and Biological Properties of Nano-hydroxyapatite-Reinforced Aliphatic Polyurethanes Membranes." Journal of Biomaterials Science, Polymer Edition 21, no. 12 (January 2010): 1619–36. http://dx.doi.org/10.1163/092050609x12524778957011.

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Yokoyama, Ritsuko, Yoshio Fujii, Yoko Noguchi, Tomohiko Nomura, Masahiko Akita, Kojun Setsu, Shigeo Yamamoto, and Keinosuke Okamoto. "Physicochemical and Biological Properties of an Extracellular Serine Protease ofAeromonas sobria." Microbiology and Immunology 46, no. 6 (June 2002): 383–90. http://dx.doi.org/10.1111/j.1348-0421.2002.tb02710.x.

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Wang, Fang, Yue Chen, Ye Huang, Hong-Wei Jin, Liang-Ren Zhang, Zhen-Jun Yang, and Li-He Zhang. "Synthesis, physicochemical and biological properties of oligonucleotides incorporated with amino-isonucleosides." Science China Chemistry 55, no. 1 (December 2, 2011): 70–79. http://dx.doi.org/10.1007/s11426-011-4465-x.

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Laskus, Aleksandra, Anna Zgadzaj, and Joanna Kolmas. "Zn2+ and SeO32− co-substituted hydroxyapatite: Physicochemical properties and biological usefulness." Ceramics International 45, no. 17 (December 2019): 22707–15. http://dx.doi.org/10.1016/j.ceramint.2019.07.308.

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