Journal articles on the topic 'Physical functioning /SF-36'
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van den Hoek, Joëlle, Leo D. Roorda, Hendriek C. Boshuizen, Gerard J. Tijhuis, Geertrudis A. van den Bos, and Joost Dekker. "Physical and Mental Functioning in Patients with Established Rheumatoid Arthritis over an 11-year Followup Period: The Role of Specific Comorbidities." Journal of Rheumatology 43, no. 2 (January 15, 2016): 307–14. http://dx.doi.org/10.3899/jrheum.150536.
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Objective.To investigate the longterm association of a wide range of comorbidities with physical and mental functioning in patients with rheumatoid arthritis (RA).Methods.Longitudinal data over a period of 11 years were collected from 882 patients with RA. Somatic comorbidity and comorbid depression were measured at baseline, with a questionnaire including 20 chronic diseases and with the Center for Epidemiologic Depression Scale, respectively. Physical functioning was measured at 5 timepoints with a disease-specific measure [Health Assessment Questionnaire (HAQ)] and a generic measure [physical scales of the Medical Outcomes Study Short Form-36 (SF-36)]. Mental functioning was measured with the mental scales of the SF-36. To determine the association of baseline-specific comorbidities with functioning over time, we performed longitudinal analyses.Results.At baseline, 72% percent of the patients were women, mean age ± SD was 59.3 ± 14.8 years, median RA disease duration was 5.0 years, and 68% had ≥ 1 comorbid condition. The effect of comorbid conditions was more apparent when physical functioning was measured with SF-36, a disease-generic measure, compared with the HAQ, a disease-specific measure. Circulatory conditions and depression were associated (p < 0.05) with worse physical functioning according to the HAQ. Respiratory conditions, musculoskeletal conditions, cancer, and depression were associated (p < 0.05) with worse physical functioning according to the SF-36. Respiratory conditions and depression were associated with worse mental functioning.Conclusion.Patients with specific comorbid conditions have an increased risk of low functioning in the long term. Targeted attention for these specific comorbid conditions by clinicians is recommended.
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Saverino, Alessia, Eva Zsirai, Raphael Sonabend, Lorenza Gaggero, Isabella Cevasco, Caterina Pistarini, and Paolo Cremonesi. "Health related quality of life in COVID-19 survivors discharged from acute hospitals: results of a short-form 36-item survey." F1000Research 10 (April 12, 2021): 282. http://dx.doi.org/10.12688/f1000research.50781.1.
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Background: Health-related quality of life (HRQL) is important for evaluating the impact of a disease in the longer term across the physical and psychological domains of human functioning. The aim of this study is to evaluate HRQL in COVID-19 survivors in Italy using the short form 36-items questionnaire (SF-36). Methods: This is an observational study involving adults discharged home following a coronavirus disease 2019 (COVID-19)-related hospital admission. Baseline demographic and clinical data including the Cumulative Illness Rating Scale (CIRS) and the Hospital Anxiety and Depression Scale (HADS) were collected. The validated Italian version of SF-36 was administered cross-sectionally. The SF-36 contains eight scales measuring limitations in physical and social functioning, the impact on roles and activities, fatigue, emotional well-being, pain and general health perception. Results: A total of 35 patients, with a mean age of 60 years, completed the SF-36. The results showed difficulties across the physical and psychological domains, particularly affecting the return to previous roles and activities. A higher burden of co-morbidities as well as a more severe muscle weakness was associated to a lower physical functioning. Younger age, rather than older, correlated to a perceived greater limitation in physical functioning and vitality. Conclusions: COVID-19 survivors particularly the ones of working age may need support for resuming their premorbid level of functioning and returning to work.
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Marn-Vukadinovic, Dusa, and Helena Jamnik. "Validation of the Short Form-36 Health Survey Supported With Isokinetic Strength Testing After Sport Knee Injury." Journal of Sport Rehabilitation 20, no. 3 (August 2011): 261–76. http://dx.doi.org/10.1123/jsr.20.3.261.
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Context:Valid patient-based outcome instruments are necessary for comprehensive patient care that focuses on all aspects of health, from impairments to participation restrictions.Objective:To validate the Slovenian translation of Medical Outcome Survey (MOS) Short Form Health Survey (SF-36) and to assess relations among various knee measurements, activity tested with Oxford Knee Score (OKS) and health-related quality of life as estimated with SF-36 domains.Design:Descriptive validation study.Setting:Isokinetic laboratory in outpatient rehabilitation unit.Participants:101 subjects after unilateral sport knee injury.Interventions:All subjects completed the SF-36 and OKS, and isokinetic knee-muscle strength output at 60°/s was determined in 78 participants. Within a 3-d period, 43 subjects completed the SF-36 and OKS questionnaires again.Main Outcome Measures:Reliability testing included internal consistency and test–retest reliability. Correlations between SF-36 subscales and OKS were calculated to assess construct validity, and correlation between SF-36 subscales and muscle strength was calculated to assess concurrent validity.Results:Chronbach α was above .78 for all SF-36 subscales. ICCs ranged from .80 to .93. The correlation between OKS and the physical-functioning subscale, showing convergent construct validity, was higher (r = .83, P < .01) than between OKS and mental health (r = .50, P < .01), showing divergent construct validity. Knee-extensor weakness negatively correlated with physical-functioning (r = −.59, P < .01) and social-functioning (r = −.43, P < .01) subscales.Conclusions:The Slovenian translation of the SF-36 is a reliable and valuable tool. The relationships between knee-muscle strength and activity and between knee-muscle strength and SF-36 subscales in patients after sport knee injury were established.
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Taylor-Gjevre, Regina M., Anthony Wassef, Bindu Nair, John A. Gjevre, and Thomas Wilson. "A questionnaire assessment of physical function in hyperlipidemic patients." Clinical & Investigative Medicine 33, no. 4 (August 1, 2010): 261. http://dx.doi.org/10.25011/cim.v33i4.14229.
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Background: A spectrum of myopathic manifestations has been recognized as associated with lipid lowering drug therapy (LLT), but their effect on quality of life and physical functioning is uncertain. We conducted a prospective cohort study in which physical functioning was the dependent variable, in patients with and without exposure to LLT. Methods: Consecutive patients attending a risk reduction clinic were invited to participate in a questionnaire study which included demographic data, muscular symptoms, the SF-36 Physical Function Score (PF), and the modified Health Assessment Questionnaire (mHAQ). Laboratory and co-morbidity data was recorded. Results: Of 117 consecutive patients invited to participate, 112 consented. Of these, 81 were receiving statins and/or fibrates as LLT and 31 were participating in a non-pharmacologic therapeutic program (NPT) of diet and exercise therapy. The mean age for the total population was 56.7 years (20-78): the LLT group 58.6 and NPT group 51.9 years. Women comprised 53% of the LLT group and 58% of the NPT. No significant differences in baseline lipid profiles, CK level, BMI, waist measurement, gender, cigarette smoking, alcohol consumption, non-steroidal anti-inflammatory drugs or acetaminophen use, frequency of myalgias, SF-36 PF or mHAQ scores were observed between groups. On comparison of gender groups, we observed that men receiving LLT had significantly better SF- 36 PF (p = 0.037) than men on NPT. There were no differences in SF-36 PF or mHAQ scores between groups for females. Conclusion: We found no adverse effects of LLT on physical functioning or quality of life. Indeed, men treated with LLT had significantly better SF-36 PF scores than men treated non-pharmacologically.
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Davidson, Megan, Jennifer L. Keating, and Sophie Eyres. "A Low Back-Specific Version of the SF-36 Physical Functioning Scale." Spine 29, no. 5 (March 2004): 586–94. http://dx.doi.org/10.1097/01.brs.0000103346.38557.73.
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Grande, Gunn E., Morag C. Farquhar, Stephen I. G. Barclay, and Christopher J. Todd. "Quality of life measures (EORTC QLQ-C30 and SF-36) as predictors of survival in palliative colorectal and lung cancer patients." Palliative and Supportive Care 7, no. 3 (September 2009): 289–97. http://dx.doi.org/10.1017/s1478951509990216.
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AbstractObjective:Self-reported health-related quality of life (HRQoL) is an important predictor of survival alongside clinical variables and physicians' prediction. This study assessed whether better prediction is achieved using generic (SF-36) HRQoL measures or cancer-specific (EORTC QLQ-C30) measures that include symptoms.Method:Fifty-four lung and 46 colorectal patients comprised the sample. Ninety-four died before study conclusion. EORTC QLQ-C30 and SF-36 scores and demographic and clinical information were collected at baseline. Follow-up was 5 years. Deaths were flagged by the Office of National Statistics. Cox regression survival analyses were conducted. Surviving cases were censored in the analysis.Results:Univariate analyses showed that survival was significantly associated with better EORTC QLQ-C30 physical functioning, role functioning, and global health and less dyspnea and appetite loss. For the SF-36, survival was significantly associated with better emotional role functioning, general health, energy/vitality, and social functioning. The SF-36 summary score for mental health was significantly related to better survival, whereas the SF-36 summary score for physical health was not. In the multivariate analysis, only the SF-36 mental health summary score remained an independent, significant predictor, mainly due to considerable intercorrelations between HRQoL scales. However, models combining the SF-36 mental health summary score with diagnosis explained a similar amount of variance (12%–13%) as models combining diagnosis with single scale SF-36 Energy/Vitality or EORTC QLQ-C30 Appetite Loss.Significance of results:HRQoL contributes significantly to prediction of survival. Generic measures are at least as useful as disease-specific measures including symptoms. Intercorrelations between HRQoL variables and between HRQoL and clinical variables makes it difficult to identify prime predictors. We need to identify variables that are as independent of each other as possible to maximize predictive power and produce more consistent results.
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Kitajima, Izuru, Kazureru Doi, Yasunori Hattori, Semih Takka, and Emmanuel Estrella. "EVALUATION OF QUALITY OF LIFE IN BRACHIAL PLEXUS INJURY PATIENTS AFTER RECONSTRUCTIVE SURGERY." Hand Surgery 11, no. 03 (January 2006): 103–7. http://dx.doi.org/10.1142/s0218810406003279.
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To evaluate the subjective satisfaction of brachial plexus injury (BPI) patients after surgery based on the medical outcomes study 36-item short form health survey (SF-36) and to correlate their SF-36 scores with upper extremity functions. Four items were assessed statistically for 30 patients: SF-36 scores after BPI surgery were compared with Japanese standard scores; the correlation between SF-36 scores and objective joint functions; difference in SF-36 scores between each type of BPI; and influence of each joint function on the SF-36 scores. The SF-36 subscale: PF — physical functioning, RP — role-physical, BP — bodily pain, and the summary score PCS — physical component summary, were significantly inferior to the Japanese standard scores. SF-36 is more sensitive to shoulder joint function than to elbow and finger joint functions. Little correlation was found between SF-36 scores and objective evaluations of joint functions. Greater effort is needed to improve the quality of life (QOL) of BPI patients. This study showed that SF-36 is not sensitive enough to evaluate regional conditions. A region- or site-specific questionnaire is required to evaluate upper extremity surgery.
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Kuan, Edward, Frederick Yoo, Jennifer Chyu, Angela Oh, Marvin Bergsneider, and Marilene Wang. "Quality of Life before and after Endoscopic Pituitary Surgery as Measured by the Short-Form-36." Journal of Neurological Surgery Part B: Skull Base 79, no. 03 (November 7, 2017): 314–18. http://dx.doi.org/10.1055/s-0037-1608648.
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Objectives/Hypotheses To assess quality of life (QOL) after transnasal, endoscopic pituitary surgery using the 36-item short form (SF-36) instrument. Design Retrospective review was used for this study. Setting The study was conducted in a tertiary academic medical center. Participants Patients who underwent endoscopic, transnasal, transsphenoidal surgery for pituitary adenomas between January 1, 2007 and July 1, 2016 and completed preoperative and postoperative SF-36 surveys. Main Outcome Measures SF-36 survey data as measured by its eight domains (physical functioning, physical role functioning, emotional role functioning, energy/fatigue, emotional well-being, social functioning, pain, and general health). Results There were 18 preoperative, 13 short-term (2 weeks or less after surgery) postoperative, and 14 longer term (>2 weeks after surgery) postoperative surveys. There was no significant difference between preoperative and long-term postoperative SF-36 scores across domains (p > 0.05). In comparing short-term postoperative and preoperative scores, tumor size was positively associated with emotional well-being (p = 0.049) and general health scores (p = 0.031), while visual changes preoperatively were positively associated with general health scores (p = 0.046). Compared with standard U.S. general population summary data, these patients scored lower preoperatively in all domains except for emotional role functioning and pain (p < 0.05). Postoperatively, patients improved to baseline general population data scores with the exception of the physical role functioning domain (p < 0.0001). Conclusion Patients undergoing endoscopic, transnasal, transsphenoidal surgery for pituitary adenomas had lower QOL in six of eight domains preoperatively, but improved to baseline values on the long run after surgery in seven of eight domains. This suggests that minimally invasive pituitary surgery has a restorative role in general QOL as measured by the SF-36.
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Strohonova, Tatyana, Maria Bondar, and Suren Varzhapetian. "Discriminant analysis for defining quality of life patients with comorbid pathology of osteoarthrosis." Proceedings of the International Conference on Applied Statistics 1, no. 1 (October 1, 2019): 458–62. http://dx.doi.org/10.2478/icas-2019-0039.
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Abstract There has been a shift in medicine from relying on clinical biomarkers to including patient-reported outcome measures. From a healthcare perspective, health-related quality of life (HRQOL) measures can be used to enhance patient care and reducing treatment cost for patients. Given the possible importance of Medical Outcome Study in medicine, and the conflicting reports in literature about its use in healthcare, it is important to identify its utility within the medical community. In this study 150 people were recruited prospectively from patients at the Hospital and the emergency сenter №1 in Zaporizhzhya, Ukraine. Four groups were formed. The inclusion criteria to group were different comorbid pathology of osteoarthrosis. We assessed patients HRQOL SF-36 SF-36 changes before and after pharmacotherapy (over 1 year), than it were compared with the control group. The validity of the construct has been analyzed by discriminant analysis. To assess SF-36 ability identifying discriminating functions were developed, determine its prediction value, define which scales of SF-36 are the best predictors for every groups. In addition, canonical analysis demonstrates SF-36 ability to estimate effect of pharmacotherapy. Statistical analysis show that all indices quality of life through SF – 36 scales except of third (physical role functioning, physical functioning, emotional role functioning) have prognostic value (p>0.05) and validity of SF-39 scales for examination of the patients with coexisting disease is statistically significant(p<0.05).
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Janssens, A. CJW, P. A. van Doorn, J. B. de Boer, N. F. Kalkers, F. GA van der Meché, J. Passchier, and R. Q. Hintzen. "A nxiety and depression influence the relation between disability status and quality of life in multiple sclerosis." Multiple Sclerosis Journal 9, no. 4 (August 2003): 397–403. http://dx.doi.org/10.1191/1352458503ms930oa.
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Disability status, depression and anxiety are important determinants of quality of life (Q oL) in patients with multiple sclerosis (MS). We investigated whether anxiety and depression influence the relation between disability status and Q oL in our cohort of recently diagnosed patients. Disability status [Expanded Disability Status Scale (EDSS)], anxiety and depression [Hospital A nxiety and Depression Scale (HADS)], and Q oL (SF-36) were prospectively obtained in 101 MS patients. The relation between EDSS and SF-36 scales was examined using regression analyses, without and with adjustment for anxiety and depression. Interaction effects were investigated by comparing the relation between EDSS and Q oL in patients with high and low anxiety and depression. In the unadjusted analyses, EDSS was significantly related to all SF-36 physical and mental health scales. A fter adjustment for anxiety and depression, EDSS was significantly related only to the SF-36 physical functioning, role-physical functioning and bodily pain scales. The relation between EDSS and these SF-36 scales was consistently higher in patients with more symptoms of anxiety or depression, suggesting that anxiety and depression strengthened the association of EDSS in these SF-36 physical health scales. A fter adjustment for anxiety and depression, EDSS was not significantly related to the SF-36 mental health scales and the general health scale. This finding is compatible with the hypothesis that anxiety and depression are intermediate factors in the association of EDSS with these SF-36 scales. Screening for symptoms of anxiety and depression is recommended in studies that use Q oL as an outcome measure of treatment or intervention efficacy.
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Olszewska-Czyz, Iwona, Sarkis Sozkes, and Agata Dudzik. "Clinical Trial Evaluating Quality of Life in Patients with Intra-Oral Halitosis." Journal of Clinical Medicine 11, no. 2 (January 10, 2022): 326. http://dx.doi.org/10.3390/jcm11020326.
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Halitosis is considered to be extremely unattractive in the context of social interactions. The main research objective of this study was to evaluate whether intra-oral halitosis may impact patients’ quality of life (QOL). One hundred generally healthy adult participants complaining about oral malodor and diagnosed with intra-oral halitosis were enrolled in this study. For halitosis diagnosis, a gas chromatography (GC) analysis by the Oral Chroma portable device was used. QOL assessment was based on the Short Form 36-item Health Survey (SF-36). The respondents had the highest scores in the physical functioning (PF), activity limitations caused by emotional problems (RE) and activity limitations caused by physical problems (RP) domains, and the weakest in the general health perception (GH), vitality (VT) and emotional wellbeing (MH) ones. The total volatile sulfur compounds (VSCs) level was negatively correlated with SF-36 domains. The SF-36 domains’ scores decreased the higher the level of VSC was. The respondents assessed their QOL to be at its best in physical functioning and activity limitations caused by emotional and physical problems and the worst in general health perception, vitality and emotional wellbeing. The strongest correlation between halitosis and decreased QOL was found in the social functioning (SF), vitality, emotional wellbeing and general health perception domains.
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Kurnik-Łucka, Magdalena, Dominika Grońska, Marcin Wojnarski, Paweł Pasieka, Elżbieta Rząsa-Duran, and Krzysztof Gil. "Health-Related Quality of Life in Relation to Fruit and Vegetable Intake among Polish Pharmacists." Healthcare 10, no. 5 (May 18, 2022): 930. http://dx.doi.org/10.3390/healthcare10050930.
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A direct association between health-related quality of life (HQoL) and nutrition remains unclear, although lifestyle habits are known to impact on human health. Thus, the aim of this study was to estimate an association between dietary habits, such as vegetable and fruit consumption, in particular, and HQoL. SF-36 (RAND-SF-36) and the Dietary Habits and Nutrition Beliefs Questionnaire (KomPAN) were addressed to Polish pharmacists with a valid professional license. After the preliminary verification, 667 pharmacists were included into the study, and altogether, 11 questions from the KomPAN questionnaire and all RAND-SF-36 multiple choice questions were processed for statistical analysis. All HQoL scores, excluding physical functioning and role-physical, were significantly higher in the group declaring fruit consumption ≥1 time per day (p < 0.005), while physical functioning (p = 0.008) and general health (p = 0.03) were significantly higher in the group declaring vegetable consumption ≥1 time per day. Thus, there is indeed a positive association between vegetable and fruit consumption and HQoL. Increased fruit intake could certainly impact on the health-related quality of life of Polish pharmacists, primarily in terms of mental functioning, while increased vegetable intake could impact in terms of physical functioning.
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Heiligenstein, John H., John E. Ware, Jr, Kathy M. Beusterien, Paul J. Roback, Carol Andrejasich, and Gary D. Tollefson. "Acute Effects of Fluoxetine Versus Placebo on Functional Health and Well-Being in Late-Life Depression." International Psychogeriatrics 7, S1 (October 1995): 125–37. http://dx.doi.org/10.1017/s1041610295002407.
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In a randomized 6-week trial comparing fluoxetine with placebo, the Medical Outcomes Study 36-Item Short-Form Health Status Survey (SF-36) scales were used to measure the effects of treatment on functional health and well-being among elderly (age ≥ 60 years) outpatients with major depression. In the fluoxetine and placebo groups, 261 and 271 patients, respectively, completed the SF-36 before treatment and at Weeks 3 and 6. Compared with national norms for individuals over age 60, study patients before treatment exhibited baseline decrements on the following SF-36 scales: mental health, role limitations due to emotional problems, social functioning, vitality, role limitations due to physical problems, and bodily pain. Analyses of SF-36 changed scores from baseline to Week 6 revealed that the fluoxetine group improved more than the placebo group across all scales. Differences in changes of scores between groups were significant (p < .05), favoring the fluoxetine group for the scales of mental health, role limitations due to emotional problems, physical functioning, and bodily pain. Improvements observed in the fluoxetine group were both clinically and socially significant.
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Gürol, Barış, Gülsün Güven, and Dilek Yalız-Solmaz. "The Effects of Teacher Candidates’ Physical Activity Levels on Health-Related Quality of Life." International Education Studies 12, no. 11 (October 28, 2019): 178. http://dx.doi.org/10.5539/ies.v12n11p178.
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The aim of this research was to determine the effects of physical activity levels of teacher candidates on the sub-dimensions of health-related quality of life. In the research among the quantitative research methods, relational survey model was used. A total of 90 teacher candidates participated in this research. The International Physical Activity Questionnaire-Short Form (IPAQ-SF) and the 36-Item Short Form Health Survey (SF-36) were used in this study. In the data analysis, “percentage, frequencies, standard deviation, mean, Product-Moment Correlation coefficients and Multiple regression” were used. According to the results, role functioning/emotional, pain and general health sub-dimensions are important predictors on physical activity levels. However, physical functioning, emotional well-being, vitality, social functioning, role functioning/physical, sub-dimensions have not an important impact on physical activity levels statistically. As a conclusion, participation in physical activity can be said to have a negative effect on emotional problems and pain, and a positive effect on general health status.
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Pék, Emese, István Mártai, József Marton, and József Betlehem. "Health survey of ambulance workers with the help of generic questionnaire (SF-36)." Orvosi Hetilap 154, no. 47 (November 2013): 1865–72. http://dx.doi.org/10.1556/oh.2013.29746.
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Introduction: The high work-related stress among ambulance workers is a widely known a phenomenon. Aim: The aim of the authors was to asses self-reported health status of ambulance workers. Method: An anonym self-fill-in questionnaire applying SF-36 was used among workers from the northern and western regions of Hungarian National Ambulance Service. Results: Based on the dimensions of the SF-36 questionnaire the responders considered their “Physical Functioning” the best, while “Vitality” was regarded the worst. The more time an employee have been worked at the Ambulance Service the worse his health was in the first four dimensions including “Physical Functioning”, “Role-Physical”, “Bodily Pain” and “General Health”: p<0.001. Those working in part-time jobs considered their health in all dimensions worse. The respondents who did some kind of sports hold their health in all dimensions better (p<0.001). The workers with higher body mass index regarded their health status worse, in four dimensions: “Physical Functioning” (p = 0.001), “Role-Physical” (p = 0.013), “General Health” (p<0.001) and “Role-Emotional” (p = 0.05). Conclusions: According to the subjective perception of health and measurable parameters of health status of workers proved to be insufficient. Poor physical health can lead indirectly to psychological problems, which may lower the quality of the work and can lead to high turn-over. Orv. Hetil., 154(47), 1865–1872.
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Nishikawa, Hiroki, Hirayuki Enomoto, Kazunori Yoh, Yoshinori Iwata, Yoshiyuki Sakai, Kyohei Kishino, Naoto Ikeda, et al. "Health-Related Quality of Life in Chronic Liver Diseases: A Strong Impact of Hand Grip Strength." Journal of Clinical Medicine 7, no. 12 (December 15, 2018): 553. http://dx.doi.org/10.3390/jcm7120553.
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We sought to examine the influence of hand grip strength (HGS) and skeletal muscle mass (SMM) on the health-related quality of life (H-QOL) as evaluated by the 36-Item Short-Form Health Survey (SF-36) questionnaire in chronic liver diseases (CLDs, 198 men and 191 women). Decreased HGS was defined as HGS <26 kg for men and <18 kg for women. Decreased SMM was defined as SMM index <7.0 kg/m2 for men and <5.7 kg/m2 for women, using bioimpedance analysis. SF-36 scores were compared between groups stratified by HGS or SMM. Between-group differences (decreased HGS vs. non-decreased HGS) in the items of physical functioning (PF), role physical (RP), bodily pain, vitality (VT), social functioning (SF), role emotional (RE), and physical component summary score (PCS) reached significance, while between-group differences (decreased SMM vs. non-decreased SMM) in the items of PF, SF and RE were significant. Multivariate analyses revealed that HGS was significantly linked to PF (p = 0.0031), RP (p = 0.0185), and PCS (p = 0.0421) in males, and PF (p = 0.0034), VT (p = 0.0150), RE (p = 0.0422), and PCS (p = 0.0191) in females. HGS had a strong influence especially in the physiological domains in SF-36 in CLDs.
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Wickerson, Lisa, Sunita Mathur, Lianne G. Singer, and Dina Brooks. "Physical Activity Levels Early After Lung Transplantation." Physical Therapy 95, no. 4 (April 1, 2015): 517–25. http://dx.doi.org/10.2522/ptj.20140173.
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Background Little is known of the early changes in physical activity after lung transplantation. Objectives The purposes of this study were: (1) to describe physical activity levels in patients up to 6 months following lung transplantation and (2) to explore predictors of the change in physical activity in that population. Design This was a prospective cohort study. Methods Physical activity (daily steps and time spent in moderate-intensity activity) was measured using an accelerometer before and after transplantation (at hospital discharge, 3 months, and 6 months). Additional functional measurements included submaximal exercise capacity (measured with the 6-Minute Walk Test), quadriceps muscle torque, and health-related quality of life (measured with the Medical Outcomes Study 36-Item Short-Form Health Survey 36 [SF-36] and the St George's Respiratory Questionnaire). Results Thirty-six lung transplant recipients (18 men, 18 women; mean age=49 years, SD=14) completed posttransplant measurements. Before transplant, daily steps were less than a third of the general population. By 3 months posttransplant, the largest improvement in physical activity had occurred, and level of daily steps reached 55% of the general population. The change in daily steps (pretransplant to 3 months posttransplant) was inversely correlated with pretransplant 6-minute walk distance (r=−.48, P=.007), daily steps (r=−.36, P=.05), and SF-36 physical functioning (SF-36 PF) score (r=−.59, P=.0005). The SF-36 PF was a significant predictor of the change in physical activity, accounting for 35% of the variation in change in daily steps. Limitations Only individuals who were ambulatory prior to transplant and discharged from the hospital in less than 3 months were included in the study. Conclusions Physical activity levels improve following lung transplantation, particularly in individuals with low self-reported physical functioning. However, the majority of lung transplant recipients remain sedentary between 3 to 6 months following transplant. The role of exercise training, education, and counseling in further improving physical activity levels in lung transplant recipients should be further explored.
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Balaska, Aikaterini, Dimitris Pistolas, Maria Koukoulaki, Dimitris Alassas, Spiros Drakopoulos, Ioannis Kaklamanos, Gerasimos Bonatsos, and Kostantinos Birbas. "Changes in Health-Related Quality of Life in Greek Adult Patients Two Years after Successful Renal Transplantation." BANTAO Journal 14, no. 1 (June 27, 2016): 30–33. http://dx.doi.org/10.1515/bj-2016-0007.
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AbstractIntroduction. This study was undertaken to compare and evaluate the heath-related quality of life (HRQOL) in Greek adult transplant recipients before and 2 years after successful renal transplantation (RT). The SF-36 survey score was used. Methods. Eighty-five Greek hemodialysis patients underwent RT at the Transplant Unit of Evangelismos General Hospital of Athens, including 44 men and 41 women (mean age 43.8 years; range 21-59 years). The scale scores of a Greek version of the SF-36 survey were compared between the transplant and the hemodialysis patients. We also examined the relationships of the scale scores with the patients′ age and the type of donor. Results. According to the SF-36 health survey, transplant recipients had better results for general health perception (p≤0.001), role-physical functioning (p≤0.01), role-emotional functioning (p≤0.01), and vitality (p≤ 0.01). In addition, the scale score of physical functioning, general health and vitality of the patients who were younger than 30 years at the time of transplantation were significantly higher than those of the patients who were older than 30 years, while the scores of bodily pain, general health, and physical functioning were significantly lower in cadaveric graft recipients compared with living-related recipients. Conclusions. The SF-36 health survey is a validated and comprehensive instrument for evaluating renal transplant patients′ HRQOL. Our data demonstrated an improvement in HRQOL in renal transplant patients 2 years after successful renal transplantation. The data also confirmed that the recipients′ age at transplantation and the type of donor were important factors affecting the HRQOL.
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Bittar Pessoa, Gregory, Bruno Rodrigues de Miranda, Leticia Zaccaria Prates de Oliveira, Herbert Amantea Fernandes, Mahmoud Beerens Abdul Ghani Abdul Ghani, Antonio Candido de Paula Neto, Álvaro Diego Pupa de Freitas, Danilo Ryuko Cândido Nishikawa, Thiago Mendonça Ferreira, and Rui Dos Santos Barroco. "Translation, cultural adaptation, and validation of the Manchester-Oxford Foot Questionnaire into Brazilian Portuguese." Journal of the Foot & Ankle 16, no. 3 (December 20, 2022): 231–36. http://dx.doi.org/10.30795/jfootankle.2022.v16.1671.
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Objective: Translate, culturally adapt and validate the Manchester-Oxford Foot Questionnaire (MOXFQ) into Brazilian Portuguese. Methods: The translation followed the guidelines standardized in the literature, including initial translation, back-translation, committee review, pre-test phase, and application of the final questionnaire in 50 patients. Intraobserver reproducibility was evaluated by reapplying the final version of the questionnaire 14 days after the first application. The validation of the final MOXFQ translation was assessed by conjoint application with the SF-36 Quality of Life questionnaire; similar domain scores of the two questionnaires were compared and analyzed. Results: Excellent reproducibility was observed for three domains with statistical significance, the intra-class correlation coefficient (ICC) values were: pain 0.98, walking/standing 0.99, and social interaction 0.98. Internal consistency/reliability obtained excellent values: pain 0.992, walking/standing 0.997, and social interaction 0.992, all with statistical significance (p<0.001). In the MOXFQ validation compared to the SF-36, the highest correlations of the study were found between the SF36 physical functioning domain and the MOXFQ walking/standing (-0.72) and social interaction domains (-0.73). Comparing the MOXFQ walking/standing domain, a good correlation was obtained with the SF-36 physical functioning (-0.41), bodily pain (-0.42), vitality (-0.45), and mental health (-0.40) domains. Also a good correlation was obtained on MOXFQ pain domain with the SF-36 physical functioning (-0.45) and social functioning (-0.43). Conclusion: The MOXFQ Brazilian version proved reliable, valid, and reproducible in measuring the symptoms and functional limitations of patients affected by foot and ankle diseases. Level of Evidence IV; Therapeutic Studies; Case Series.
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Kim, Harry K. W., Roi Almakias, Michael B. Millis, and Bella Vakulenko-Lagun. "How are adults who had Perthes’ disease functioning?" Bone & Joint Journal 104-B, no. 12 (December 1, 2022): 1304–12. http://dx.doi.org/10.1302/0301-620x.104b12.bjj-2022-0764.r1.
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Aims Perthes’ disease (PD) is a childhood hip disorder that can affect the quality of life in adulthood due to femoral head deformity and osteoarthritis. There is very little data on how PD patients function as adults, especially from the patients’ perspective. The purpose of this study was to collect treatment history, demographic details, the University of California, Los Angeles activity score (UCLA), the 36-Item Short Form survey (SF-36) score, and the Hip disability and Osteoarthritis Outcome score (HOOS) of adults who had PD using a web-based survey method and to compare their outcomes to the outcomes from an age- and sex-matched normative population. Methods The English REDCap-based survey was made available on a PD study group website. The survey included childhood and adult PD history, UCLA, SF-36, and HOOS. Of the 1,182 participants who completed the survey, the 921 participants who did not have a total hip arthroplasty are the focus of this study. The mean age at survey was 38 years (SD 12) and the mean duration from age at PD onset to survey participation was 30.8 years (SD 12.6). Results In comparison to a normative population, the PD participants had significantly lower HOOS scores across all five scales (p < 0.001) for all age groups. Similarly, SF-36 scores of the participants were significantly lower (p < 0.001) for all scales except for age groups > 55 years. Overall, females, obese participants, those who reported no treatment in childhood, and those with age of onset > 11 years had significantly worse SF-36 and HOOS scores. Pairwise correlations showed a strong positive correlation within HOOS scales and between HOOS scales and SF-36 scales, indicating construct validity. Conclusion Adult PD participants had significantly worse pain, physical, mental, and social health than an age- and sex-matched normative cohort. The study reveals a significant burden of disease on the adult participants of the survey, especially females. Cite this article: Bone Joint J 2022;104-B(12):1304–1312.
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Nishikawa, Hiroki, Kazunori Yoh, Hirayuki Enomoto, Yoshinori Iwata, Yoshiyuki Sakai, Kyohei Kishino, Yoshihiro Shimono, et al. "Health-Related Quality of Life and Frailty in Chronic Liver Diseases." Life 10, no. 5 (May 24, 2020): 76. http://dx.doi.org/10.3390/life10050076.
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We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (n = 341, 122 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: <26 kg in men and <18 kg in women), slow walking speed (<1.0 m/s), and low physical activity. Robust (frailty score 0), prefrail (frailty score 1 or 2), and frailty were found in 108 (31.7%), 187 (54.8%), and 46 (13.5%) patients, respectively. In all eight scales of the SF-36 (physical functioning, role physical, bodily pain, general health perception, vitality, social functioning, role emotion, and mental health), and the physical component summary score and mental component summary score, each score was well stratified according to the frailty status (all p < 0.0001). In the multivariate analysis, age (p = 0.0126), physical functioning (p = 0.0005), and vitality (p = 0.0246) were independent predictors linked to the presence of frailty. In conclusion, Japanese CLD patients with frailty displayed poorer conditions, both physically and mentally.
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Udugampolage, Nathasha, Rosario Caruso, Mariangela Panetta, Edward Callus, Federica Dellafiore, Arianna Magon, Susan Marelli, and Alessandro Pini. "Is SF-12 a valid and reliable measurement of health-related quality of life among adults with Marfan syndrome? A confirmatory study." PLOS ONE 16, no. 6 (June 9, 2021): e0252864. http://dx.doi.org/10.1371/journal.pone.0252864.
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Introduction The structural validity and reliability of the Short-Form Health Survey 12 (SF-12) has not yet been tested in adults with the Marfan syndrome (MFS). This gap could undermine an evidence-grounded practice and research, especially considering that the need to assess health-related quality of life in patients with MFS has increased due to the improved life expectancy of these patients and the need to identify their determinants of quality of life. For this reason, this study aimed to confirm the dimensionality (structural validity) of the SF-12, its concurrent validity, and its reliability (internal consistency). Methods We performed a cross-sectional study in a convenience sample of 111 Italian adults with MFS, collecting anamnestic and socio-demographic information, the SF-12, and short-form Health Survey 36 (SF-36). A confirmatory factor analysis was performed to verify whether the items of SF-12 related to physical restrictions, physical functioning, and bodily pain were retained by the physical summary component of the SF-12. The items referred to the role limitations due to emotional issues, social functioning, and mental health were retained by the mental summary component (MCS12). SF-36 was used to assess the concurrent validity of SF-12, hypothesizing positive correlations among the equivalent summary scores. Results The two-factor structural solution resulted in fitting the sample statistics adequately. The internal consistency was adequate for the two factors. Furthermore, the physical and mental summary scores of the SF-36 were positively correlated with their equivalent summary scores derived from the SF-12. Conclusions This study confirmed the factor structure of the SF-12. Therefore, the use of SF-12 in clinical practice and research for assessing the health-related quality of life among adults with MFS is evidence-grounded. Future research is recommended to determine whether the SF-12 shows measurement invariance in different national contexts and determine eventual demographic variation in the SF-12 scores among patients with MFS.
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Vorobets, D. Z., I. I. Horpynchenko, and Z. D. Vorobets. "Кореляція між показниками пов'язаної зі здоров’ям якості життя і формою еректильної дисфункції у чоловіків молодого та середнього віку." Visnyk of Dnipropetrovsk University. Biology, medicine 1, no. 1 (June 17, 2010): 41–49. http://dx.doi.org/10.15421/021007.
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The psychogenic erectile dysfunction (ED) does not show strong correlation between domains of questionnaires SF-36 and IIEF. In conditions of ED caused by endothelial dysfunction the domains of general health, physical functioning, bodily pain and vitality strongly correlates with all domains rates of IIEF questionnaire except overall satisfaction. In conditions of erectile dysfunction caused by chronic pelvis pain the rates of IIEF correlate with domains of physical functioning, pain, vitality from SF-36. In conditions of premature ejaculation and ED accompaniment the rates of general health, pain intensity and vitality become worth and correlate with total score of IIEF, rates of sexual desire end intercourse satisfaction.
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Bromley, Lacey, Peter J. Horvath, Susan E. Bennett, Bianca Weinstock-Guttman, and Andrew D. Ray. "Impact of Nutritional Intake on Function in People with Mild-to-Moderate Multiple Sclerosis." International Journal of MS Care 21, no. 1 (January 1, 2019): 1–9. http://dx.doi.org/10.7224/1537-2073.2017-039.
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Abstract Background: We sought to assess the associations between nutrition and ambulation, daily activity, quality of life (QOL), and fatigue in individuals with mild-to-moderate disability with multiple sclerosis (MS). Methods: This cross-sectional pilot study included 20 ambulatory adult volunteers with MS (14 women and 6 men; mean ± SD age, 57.9 ± 10.2 years; mean ± SD Expanded Disability Status Scale score = 4.1 ± 1.8). Primary outcome variables included dietary assessment and the 6-Minute Walk Test (6MWT). Secondary measures included the Timed 25-Foot Walk test, Timed Up and Go test, daily activity, and three self-report questionnaires: the 12-item Multiple Sclerosis Walking Scale, the 36-item Short Form Health Survey (SF-36), and the Modified Fatigue Impact Scale. Results: Significant correlations were seen between the percentage of diet comprising fats and the 6MWT (r = 0.51, P = .02) and the physical functioning component of the SF-36 (r = 0.47, P = .03). The percentage of carbohydrates was significantly correlated with the 6MWT (r = −0.43, P = .05), daily activity (r = −0.59, P = .005), and the physical functioning component of the SF-36 (r = −0.47, P = .03). Cholesterol, folate, iron, and magnesium were significantly positively correlated with the physical functioning component of the SF-36 and the 6MWT. Conclusions: These findings indicate better ambulation, daily function, and QOL with increased fat intake, decreased carbohydrate intake, and increased intake of the micronutrients cholesterol, folate, iron, and magnesium in people with mild-to-moderate MS. This pilot study highlights the potential impact of diet on function and QOL in MS.
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Valovich McLeod, Tamara C., R. Curtis Bay, John T. Parsons, Eric L. Sauers, and Alison R. Snyder. "Recent Injury and Health-Related Quality of Life in Adolescent Athletes." Journal of Athletic Training 44, no. 6 (November 1, 2009): 603–10. http://dx.doi.org/10.4085/1062-6050-44.6.603.
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Abstract Context: Health-related quality of life (HRQOL) is a global concept that takes into account the physical, psychological, and social domains of health. Determining the extent to which injury affects HRQOL is an important aspect of rehabilitation practice, enabling comparisons of clinical outcomes across different conditions in diverse patient groups. Objective: To examine the extent to which a self-reported recent injury affected HRQOL in adolescent athletes using 2 generic patient self-report scales. Design: Cross-sectional study. Setting: High school classrooms and athletic training facilities. Patients or Other Participants: A convenience sample of uninjured (n = 160) and injured (n = 45) adolescent athletes. Intervention(s): The independent variable was injury status: uninjured versus injured. All participants completed a self-administered brief health status questionnaire and the Short Form–36 Health Survey Questionnaire (SF-36) and Pediatric Outcomes Data Collection Instrument (PODCI) in a counterbalanced manner. Main Outcome Measure(s): Dependent variables included 8 subscale and 2 composite scores of the SF-36 and 5 subscale scores and 1 global score of the PODCI. Group differences were assessed with the Mann-Whitney U test (P ≤ .05) and reported as median and interquartile range. Results: On the SF-36, the injured group demonstrated lower scores (P < .008) for physical functioning, limitations due to physical health problems, bodily pain, social functioning, and the physical composite. On the PODCI, the injured group reported lower scores (P < .01) on the pain and comfort subscale and the global score. Conclusions: Adolescent athletes with self-reported injuries demonstrated lower HRQOL than their uninjured peers. As expected, recent injury affected physical functioning and pain. Social functioning (on the SF-36) and global HRQOL (on the PODCI) also decreased, suggesting that injuries affected areas beyond the expected physical component of health. Clinicians need to recognize the full spectrum of negative influences that injuries may have on HRQOL in adolescent athletes.
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Aseeva, E., S. Solovyev, S. Glukhova, and A. Lila. "AB0481 HEALTH-RELATED QUALITY OF LIFE ASSESSED BY LupusQoL AND SF-36 IN 400 RUSSIAN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1368.1–1368. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1569.
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BackgroundThe LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus.ObjectivesWe conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus. Both questionnaires were conducted for one visit to the clinic.MethodsDisease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined, while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman’s correlation coefficients, and Students t test were performed to analyze the data.ResultsA total of 400 patients with lupus (F/M 363:37, mean age 34,2±11.5 years, mean disease duration 106,3±91,9.0 months) were included, and 63 % of these were active and 56 % of these had SDI≥1. The mean SLEDAI 2K score was 9,6±8,0.QOL as assessed by SF-36 and LupusQoL was low in this group of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in Table 1. The mean scores are < 60 in 8 domains of the SF-36 but not in social functioning (62,03±27,19) and physical function (62,35±28,53).Table 1.Descriptive statistics and correlation coefficient for SF-36 and LupusQoLLupusQoLdomainsMean (SD)SF-36domainsMean (SD)rPComparablePhysical health66,20±23,18PF62,35±28,530,770,96Emotional health64,65±24,75MH50,51±8,400,380,94Pain70,03±24,68BP47,0±8,86-0,330,02Fatigue62,7±24,73VT53,04±22,59-0,700,83NoncomparablePlanning63,90±28,46SF62,03±27,19Intimaterelationships72,92±30,93GH49,14±20,51Burden to others50,68±27,79RE49,84±43,86Body image65,18±27,60RP40,46±41,35PCS45,15±7,65MCS48,46±5,41The MCS and PCS scores were both < 50. Despite the fact that the mean score in LupusQoL was always higher than in SF-36 for each of the comparable domains, 3 standardized p values were not statistically significant (mean score in 400 patient visits: physical health/physical function, 66,20±23,18/62,35±28,53, p = 0.96; emotional health/mental health, 64,65±24,75/50,51±8,40, p = 0.94; and fatigue/vitality 62.70 ± 24.73/53.04 ± 22.59, p = 0.83), 1 standardized p value was statistically significant - pain/bodily pain 70.03 ± 24.68/47.00 ± 8.86, p = 0.02. The correlation of the comparable domains of LupusQoL and SF-36 was studied. There was a strong correlation between comparable domains in LupusQoL and SF-36 in 400 patient visits (physical health and physical functioning, r = 0.77; emotional health and role emotional, r = 0.38; pain and bodily pain, r = -0,33; and fatigue and vitality, r =- 0.70; all p values < 0.0001).For the 4 non-comparable domains of the LupusQoL, there was a correlation between 3 domains of LupusQoL and 1 of the component scores of SF-36: body image and SF-36 MCS, r = 0.20; planning and SF-36 MCS, r = 0.13, r = 0.73; and burden to others and SF-36 MCS, r = 0.19; body image and SF-36 PCS,r=0,38; planning and SF-36 PCS,r=0,66; and burden to others and SF-36 PCS,r=0,38.ConclusionThe LupusQoL-Russian is sensitive to change in SLE patients with active SLE. LupusQoL and SF-36 were equivalent in assessing the HRQOL in the Russian SLE patients. Both LupusQoL and SF-36 are easily completed by patients and correlate very well with each other.Disclosure of InterestsNone declared
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Martin, Helen C., Jagjit Sethi, Dorothy Lang, Glen Neil-Dwyer, Mark E. Lutman, and Lucy Yardley. "Patient-assessed outcomes after excision of acoustic neuroma: postoperative symptoms and quality of life." Journal of Neurosurgery 94, no. 2 (February 2001): 211–16. http://dx.doi.org/10.3171/jns.2001.94.2.0211.
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Object. The aim of this study was to assess whether outcomes from excision of acoustic neuroma vary among patients and have a material impact on their quality of life (QOL). Methods. A questionnaire concerning postoperative symptoms and the Short Form 36 (SF-36) QOL instrument were mailed to 97 consecutive patients who had undergone acoustic neuroma surgery via the translabyrinthine approach. The survey response rate was 78% and the symptomatology was consistent with other reports, supporting the representativeness of the sample. The respondents' QOL was rated significantly below published norms and their work capacity was reportedly reduced. Specifically, the following SF-36 dimensions were reduced: physical functioning and role-physical, together with vitality, general health, and social functioning. Greater numbers of postoperative symptoms and larger tumors were associated with a worse rating of physical functioning. More severe balance problems were associated with lower ratings of social functioning. The disparity between the patient's self-estimate and self-measurement and the clinician's assessment of the patient's facial functioning raises doubts about the validity of subjective reports and assessment. Conclusions. The present study supports the use of generic QOL measures to assess outcome and to draw comparisons between different populations.
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Vrettos, I., A. Papadopoulos, K. Kamposioras, D. Charitos, G. Giannopoulos, D. Pectasides, D. Niakas, and T. Economopoulos. "Corrleation of health-related quality of life (HRQL) of cancer patients and the mental component parameters of their family members." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): e20619-e20619. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e20619.
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e20619 Background: It is widely experienced that health-related quality of life (HRQL) is greatly influenced in the family members of cancer patients. The aim of this study was to find the correlation of the HRQL parameters in cancer patients with the main mental component parameters of patients’ relatives. Methods: 122 cancer patients undergoing chemotherapy in our department (49 men and 73 women) of mean age 56.6 ±15.4 1SD and their 122 relatives that accompanied them (45 men and 77 women) of mean age 48.3 ±14.5 completed the validated SF-36 health survey by personal interview. The SF-36 health survey summarizes the functional health status and general health into eight scales with higher scores (0–100 range) reflecting better-perceived health. In this study, physical functioning (PF), role physical (RP), bodily pain (BP), general health perception (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MH) of the patients were correlated with the SF, RE, MH of their family members using the Spearman's test. Data analysis was performed with SPSS version 13.0 and correlations were considered statistically significant when p<0.05. Results: Table 1 summarizes the results of our study. Social Functioning and Mental Health of family members are highly correlated with the HRQL parameters of cancer patients. The RE does not seem to be affected. Conclusions: HRQL of cancer patients undergoing chemotherapy is highly correlated with the SF and the MH of their relatives. This observation highlights the need to develop more oriented supportive programs for both the patients and their family memebers. Abbreviations: PF = Physical Functioning, RP = Role Physical, BP = Bodily Pain, GH = General Health, VT = Vitality, SF = Social Functioning, RE = Role Emotional, MH = Mental Health; NS=Not Significant. * = 0.05. ** = 0.01. [Table: see text] No significant financial relationships to disclose.
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Silva, Vanderleia Costa, Manuella Sampaio Almeida, Vania T. M. Hungria, Leina Yukari Etto, José Salvador Rodrigues de Oliveira, José Carlos Barros, Rozana Ciconelli, and Gisele W. B. Colleoni. "Quality of Life Assessment at Diagnosis and after Different Treatment Phases in Multiple Myeloma Brazilian Patients." Blood 112, no. 11 (November 16, 2008): 5154. http://dx.doi.org/10.1182/blood.v112.11.5154.5154.
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Abstract Multiple myeloma (MM) causes great impact in quality of life (Q/L), since patients become dependant of others even for routine activity execution and personal care. Objectives: To characterize the impact of MM in the Q/L of patients treated in two public institutions of Sao Paulo State, Brazil, using a generic (SF-36) and a specific questionnaire for oncologic patient (QLQ-C30), applied in three different moments: at diagnosis, after the end of clinical treatment and at day +100 after autologous hematopoietic stem cell transplant (ASCT). Patients and methods: From March 2006 to August 2007 we evaluated 49 patients with MM, using the two questionnaires. Analysis was made through ANOVA, Post hoc and T-paired test comparing the three groups. Results: 88.6% of included patients have family budget lower than US$ 600.00/month (Economic Class C, D or E). The generic questionnaire SF-36 demonstrated that Physical Functioning, Role-Physical and Bodily Pain were statistically different in all three groups, favoring the day +100 post-ASCT group (ANOVA). SF-36 still demonstrated improvement in Role-Emotional when MM post treatment group was compared with the day + 100 post-ASCT group (T-paired Test). The QLQ-C30 questionnaire confirmed what had been demonstrated by the SF-36 in relation to the Physical Functioning and Bodily Pain plus improvement in the following aspects: Role Functioning, Fatigue, Lack of Appetite and Constipation, favoring the day + 100 post-ASCT group (ANOVA). QLQ-C30 also detected a significant improvement in Social Aspect in patients with MM after day +100 of ASCT. Conclusion: The specific questionnaire for cancer patients QLQ-C30 seems to be more informative than the generic questionnaire SF-36 and reflects the real benefit of ASCT in Q/L of MM patients from two public Brazilian institutions, which provide assistance for economically challenged population.
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Razvi, Salman, Lorna E. Ingoe, Carolyn V. McMillan, and Jolanta U. Weaver. "Health status in patients with sub-clinical hypothyroidism." European Journal of Endocrinology 152, no. 5 (May 2005): 713–17. http://dx.doi.org/10.1530/eje.1.01907.
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Objective: Sub-clinical hypothyroidism (SCH) is a common disorder. People with this condition may have symptoms which could affect their perception of health. Therefore, the perceived health status of people with SCH was assessed and compared with population-matched norms. Design: A prospective cross-sectional survey. Methods: Seventy-one adults with SCH, age range 18–64 years were studied. Perceived health status was measured by the Short Form-36 (SF-36) version 2 questionaire, which has been validated in a UK population setting. The SF-36 has eight scales measuring physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional and mental health. Their SF-36 scores were compared with UK normative data after matching for age and sex and are reported as z-scores. Results: Scores of all eight SF-36 scales were significantly lower in people with SCH compared with the normative population. A negative score (compared with zero of the normative population) indicates worse health status. The most significantly impaired aspects of health status were vitality and role limitations due to physical problems (role physical scale) with z-scores (95% confidence intervals) of −1.01 (−0.74 to −1.29) and −0.73 (−0.43 to −1.04) respectively. Thyroid autoimmunity did not influence the results. Conclusion: Perceived health status is significantly impaired in people with SCH when compared with UK normative population scores. This needs to be taken into consideration by clinicians when managing patients with this disease.
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McFann, Kim, Bridget A. Baxter, Stephanie M. LaVergne, Sophia Stromberg, Kailey Berry, Madison Tipton, Jared Haberman, et al. "Quality of Life (QoL) Is Reduced in Those with Severe COVID-19 Disease, Post-Acute Sequelae of COVID-19, and Hospitalization in United States Adults from Northern Colorado." International Journal of Environmental Research and Public Health 18, no. 21 (October 21, 2021): 11048. http://dx.doi.org/10.3390/ijerph182111048.
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The longitudinal quality of life (QoL) of COVID-19 survivors, especially those with post-acute sequelae (PASC) is not well described. We evaluated QoL in our COVID-19 survivor cohort over 6 months using the RAND SF-36 survey. From July 2020–March 2021 we enrolled 110 adults from the United States with a positive SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) into the Northern Colorado Coronavirus Biobank (NoCo-COBIO). Demographic data and symptom surveillance were collected from 62 adults. In total, 42% were hospitalized, and 58% were non-hospitalized. The Rand SF-36 consists of 36 questions and 8 scales, and questions are scored 0–100. A lower-scale score indicates a lower QoL. In conclusion, hospitalization, PASC, and disease severity were associated with significantly lower scores on the RAND SF-36 in Physical Functioning, Role Limitation due to Physical Health, Energy/Fatigue, Social Functioning, and General Health. Long-term monitoring of COVID-19 survivors is needed to fully understand the impact of the disease on QoL and could have implications for interventions to alleviate suffering during recovery.
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Fábrega-Cuadros, Raquel, Fidel Hita-Contreras, Antonio Martínez-Amat, José Daniel Jiménez-García, Alexander Achalandabaso-Ochoa, Leyre Lavilla-Lerma, Patricia Alexandra García-Garro, Francisco Álvarez-Salvago, and Agustín Aibar-Almazán. "Associations between the Severity of Sarcopenia and Health-Related Quality of Life in Community-Dwelling Middle-Aged and Older Adults." International Journal of Environmental Research and Public Health 18, no. 15 (July 29, 2021): 8026. http://dx.doi.org/10.3390/ijerph18158026.
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(1) Background: The aim of this study was to analyze the associations between severity of sarcopenia and health-related quality of life (HRQoL) among community-dwelling middle-aged and older adults. (2) Methods: A cross-sectional study involving 304 older-adult participants was used to assess the severity of sarcopenia by measuring muscle strength (handgrip dynamometer), muscle mass (bioelectrical impedance analysis), and physical performance (Timed Up-and-Go test). The generic 36-item Short-Form Health Survey (SF-36) was used to evaluate HRQoL. Anxiety and depression (Hospital Anxiety and Depression Scale) as well as age were considered as possible confounders. Probable sarcopenia was determined by low muscle strength; confirmed sarcopenia was defined by the presence of both low muscle strength and muscle mass; and severe sarcopenia was defined by low muscle strength and mass along with poor physical performance. (3) Results: The linear regression analysis showed that the presence of probable sarcopenia was associated with the SF-36 domains physical role (adjusted R2 = 0.183), general health (adjusted R2 = 0.290), and social functioning (adjusted R2 = 0.299). As for the SF-36 mental (MCS) and physical (PCS) component summary scores, probable sarcopenia, as well as depression and anxiety, remained associated with MCS (adjusted R2 = 0.518), and these three variables, together with age, were linked to PCS (adjusted R2 = 0.340). (4) Conclusions: Probable sarcopenia, but not confirmed or severe sarcopenia, was independently associated with poor HRQoL. More precisely, it was related to PCS and MCS, as well as to the physical role, general health, and social functioning of SF-36 domains.
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Gomez, Alvaro, Sofia Soukka, Petter Johansson, Emil Åkerström, Sharzad Emamikia, Yvonne Enman, Katerina Chatzidionysiou, and Ioannis Parodis. "Use of Antimalarial Agents Is Associated with Favourable Physical Functioning in Patients with Systemic Lupus Erythematosus." Journal of Clinical Medicine 9, no. 6 (June 10, 2020): 1813. http://dx.doi.org/10.3390/jcm9061813.
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Impaired health-related quality of life (HRQoL) is a major problem in patients with systemic lupus erythematosus (SLE). Antimalarial agents (AMA) are the cornerstone of SLE therapy, but data on their impact on HRQoL are scarce. We investigated this impact using baseline data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (n = 1684). HRQoL was self-reported using the Medical Outcomes Study short-form 36 (SF-36), functional assessment of chronic illness therapy (FACIT)-Fatigue and 3-level EuroQoL 5-Dimension (EQ-5D) questionnaires. Patients on AMA (n = 1098/1684) performed better with regard to SF-36 physical component summary, physical functioning, role physical, bodily pain, FACIT-Fatigue, EQ-5D utility index and EQ-5D visual analogue scale scores. The difference in SF-36 physical functioning (mean ± standard deviation (SD): 61.1 ± 24.9 versus 55.0 ± 26.5; p < 0.001) exceeded the minimal clinically important difference (≥5.0). This association remained significant after adjustment for potential confounding factors in linear regression models (standardised coefficient, β = 0.07; p = 0.002). Greater proportions of AMA users than non-users reported no problems in the mobility, self-care, usual activities and anxiety/depression EQ-5D dimensions. AMA use was particularly associated with favourable HRQoL in physical aspects among patients with active mucocutaneous and musculoskeletal disease, and mental aspects among patients with active renal SLE. These results provide support in motivating adherence to AMA therapy. Exploration of causality in the relationship between AMA use and favourable HRQoL in SLE has merit.
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Tamura, Lilian Sarli, Everton Cazzo, Elinton Adami Chaim, and Sérgio Rocha Piedade. "Influence of morbid obesity on physical capacity, knee-related symptoms and overall quality of life: A cross-sectional study." Revista da Associação Médica Brasileira 63, no. 2 (February 2017): 142–47. http://dx.doi.org/10.1590/1806-9282.63.02.142.
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Summary Objective: To evaluate the impact of morbid obesity on physical capacity, joint-related symptoms, and on the overall quality of life. Method: Cross-sectional study carried out at a university hospital, enrolling 39 individuals admitted to a bariatric surgery service. Physical capacity was assessed by Six-Minute Walk Test (SMWT) and the Borg rating of perceived exertion (RPE). Knee-related symptoms were evaluated by Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Lysholm Score. Quality of life was evaluated by Short Form 36 Health Questionnaire (SF-36). Results: On SMWT, the mean distance walked was 374.1±107.5 m. The mean Borg score was 12.9±2.4. KOOS questionnaire found the following scores: pain (64.3±24), other symptoms (67.2±25.5), function in daily living (60.4±26.8), function in sport and recreation (28.5±32.2), knee-related quality of life (35.9±33.5), mean Lysholm scale score (55.3±25.4). SF-36 provided the following scores: physical functioning (41±27.4), physical role functioning (34.6±39.2), bodily pain (45.7±23.6), general health perceptions (63.1±26.2), vitality (53.5±12.1), social role functioning (52.6±29.3), emotional role functioning (41±44.9), mental health (55±27.7). Conclusion: Obesity led to significant loss of physical capacity, gait impairment, knee-related symptoms, and a negative impact on the overall quality of life.
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Hinchcliff, Monique E., Jennifer L. Beaumont, Mary A. Carns, Sofia Podlusky, Krishna Thavarajah, John Varga, David Cella, and Rowland W. Chang. "Longitudinal Evaluation of PROMIS-29 and FACIT-Dyspnea Short Forms in Systemic Sclerosis." Journal of Rheumatology 42, no. 1 (November 1, 2014): 64–72. http://dx.doi.org/10.3899/jrheum.140143.
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Objective.To assess the sensitivity of the Patient-Reported Outcomes Measurement Information System 29-item Health Profile (PROMIS-29) and the Functional Assessment of Chronic Illness Therapy-Dyspnea 10-item short form (FACIT-Dyspnea) for measuring change in health status and dyspnea in systemic sclerosis (SSc).Methods.One hundred patients with SSc completed the PROMIS-29, FACIT-Dyspnea, and traditional instruments [Medical Research Council Dyspnea Score, St. George’s Respiratory Questionnaire (SGRQ), Health Assessment Questionnaire-Disability Index (HAQ-DI), and Medical Outcomes Study Short Form-36 (SF-36)] at baseline and 1-year visits. PROMIS-29, FACIT-Dyspnea, and traditional instrument change scores were compared across composite modified Medsger Disease Severity and modified Rodnan Skin score (mRSS) change groups.Results.Moderately high Spearman correlation coefficients were observed between FACIT-Dyspnea and SGRQ (r = 0.57), FACIT-Dyspnea functional limitations and SF-36 physical component summary (PCS; r = 0.51), PROMIS-29 physical functioning and HAQ-DI (r = 0.50), and SF-36 PCS (r = 0.52) change scores. In most validity comparisons, PROMIS-29, FACIT-Dyspnea, HAQ-DI, and SF-36 scores performed similarly. While PROMIS-29 covers more content areas than SF-36 (e.g., sleep), it may do so at the expense of responsiveness of its 4-item physical function scale as compared to the multiitem-derived SF-36 PCS. Statistically significant increases in SF-36 role physical (p = 0.01) and physical component scale (p = 0.016), but not PROMIS-29, were observed in patients with mRSS improvement.Conclusion.PROMIS-29 and FACIT-Dyspnea are valid instruments to measure health status and dyspnea in patients with SSc. In physical function assessment, longer PROMIS short forms or computer adaptive testing should be considered to improve responsiveness to the effect of skin disease changes on physical function in patients with SSc.
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Spira, Adam P., Leah Friedman, Sherry A. Beaudreau, Sonia Ancoli-Israel, Beatriz Hernandez, Javaid Sheikh, and Jerome Yesavage. "Sleep and physical functioning in family caregivers of older adults with memory impairment." International Psychogeriatrics 22, no. 2 (November 30, 2009): 306–11. http://dx.doi.org/10.1017/s1041610209991153.
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ABSTRACTBackground:Sleep disturbance is common in caregivers of older adults with memory disorders. Little is known, however, about the implications of caregivers’ poor sleep with regard to their physical functioning.Methods:In this cross-sectional study, we investigated the association between objectively measured sleep and self-reported physical functioning in 45 caregivers (mean age = 68.6 years) who completed the Beck Depression Inventory-II, the Medical Outcomes Study SF-36, and the Mini-mental State Examination, and wore an actigraph for at least three days. Our primary predictors were actigraphic sleep parameters, and our outcome was the SF-36 Physical Functioning subscale.Results:In multivariate-adjusted linear regression analyses, each 30-minute increase in caregivers’ total sleep time was associated with a 2.2-point improvement in their Physical Functioning subscale scores (unstandardized regression coefficient (B) = 2.2, 95% confidence interval (CI) 1.0–3.4,p= 0.001). In addition, each 10-minute increase in time awake after initial sleep onset was associated with a 0.5-point decrease on the Physical Functioning subscale, although this was not statistically significant (B= −0.5, 95% CI −1.1, 0.1,p= 0.09).Conclusions:Our findings suggest that shorter sleep duration is associated with worse self-reported physical functioning in caregivers. Longitudinal studies are needed to determine whether poor sleep predicts functional decline in caregivers.
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Souza, Ismelinda Maria Diniz Mendes, Helena Borges Martins da Silva Paro, Rogerio Rizo Morales, Rogerio de Melo Costa Pinto, and Carlos Henrique Martins da Silva. "Health-related quality of life and depressive symptoms in undergraduate nursing students." Revista Latino-Americana de Enfermagem 20, no. 4 (August 2012): 736–43. http://dx.doi.org/10.1590/s0104-11692012000400014.
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This is a descriptive, cross-sectional study aimed at investigating the health-related quality of life (HRQoL) of nursing students and its relationship with year of training, sociodemographic variables and the intensity of depressive symptoms. A convenience sample of 256 students, out of 353 eligible (72%), responded to the Medical Outcomes Study - The 36 Item Short-Form Health Survey (SF-36) and the Beck Depression Inventory (BDI) (self-administered). Final-year students, females and students with a higher intensity of depressive symptoms presented lower SF-36 scores in the physical functioning, vitality and social functioning domains. Institutional psychopedagogic support programs may minimize this negative impact on the HRQoL and encourage better professional performance of students in higher vulnerability situations.
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Lo, Andrea, Normand Laperriere, David Hodgson, and Karen Goddard. "05 Long-term health-related quality of life in adult survivors of pediatric intracranial germ cell tumour." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, S3 (June 2018): S1. http://dx.doi.org/10.1017/cjn.2018.253.
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PURPOSE: To investigate health-related quality of life (HRQOL ) in survivors of intracranial germ cell tumors (IGCT). METHODS: Survivors of IGCT were invited to complete the 36-Item Short Form Survey Instrument (SF-36). The SF-36 is scored from 0-100, with a higher number representing a more favorable HRQOL. RESULTS: The study cohort consisted of 12 survivors of IGCT, 6 males and 6 females. Median age was 13 years at diagnosis, and 26 years at time of study. Median follow-up was 11 years. Five patients had germinomas, and 7 had non-germinomatous germ cell tumors. All 12 patients received radiation therapy (RT), 10 to the craniospinal axis, 1 to the whole ventricles and 1 to the tumor bed alone. Nine patients received chemotherapy. Mean SF-36 scores were 67.9 (standard deviation [SD] 33.2) for physical functioning, 58.3 (SD 37.4) for role limitations due to physical health, 77.8 (SD 32.8) for role limitations due to emotional problems, 43.1 (SD 18.4) for vitality, 74.3 (SD 15.3) for mental health; 62.5 (SD 32.0) for social functioning, 74.2 (SD 33.4) for pain, and 57.1 (SD 24.0) for general health; mean scores were >1 SD lower than that of Canadian normative data for vitality, social functioning and general health. Physical component score was 43.6 (SD 13.9) and mental component score was 47.6 (SD 11.2), normalized to a US population with mean of 50 and SD of 10. CONCLUSIONS: Long-term HRQOL for survivors of IGCT is lower than that of the overall population, particularly in vitality, social functioning and general health.
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Iftikhar, Usman, Farooq Islam, Gulraiz Enderyas, Faisal Shahbaz, Asim Raza, Sobia Azam, and Haroon Arshad. "Assessment of Quality of life among patients with hip osteoarthritis." Pakistan Journal of Medical and Health Sciences 16, no. 10 (October 30, 2022): 81–84. http://dx.doi.org/10.53350/pjmhs22161081.
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Aim: To assess quality of life in patients with hip osteoarthritis. Method: A hospital based cross sectional study was carried out involving hip osteoarthritic patients at District headquarter hospital Gujranwala. From May 2022 to Sep 2022.A total of 196 participants were included in the study. Data were collected from the patients who met the inclusion/exclusion criteria and were entered and analyzed in (SPSS) software version 24.36-Item (SF-36) was used to collect data from participants. Results: The results of the study showed that overall poor quality of life with mean scores physical functioning mean and standard deviationwas 31.13±9.73, role limitations due to physical health mean and standard deviation was 29.33±8.98, role limitations due to emotional problems mean and standard deviation was 22.60±9.31, energy/fatigue mean and standard deviation was 39.51±14.55, general health mean and standard deviation was 17.47±7.35. The goal of the study was to discover the effect of osteoarthritis on standard of living as well as their relationship with eight subscales of sf-36 as many people are not aware about their developed disease and my study will provide information regarding this disease in future. Conclusion: According to the findings of the study, Quality of life is significantly poor in hip osteoarthritis patients. Physical functioning, Role limitations due to physical health, General healthwere the most affected SF-36 subgroups. Keywords: Quality of life, Hip osteoarthritis, SF-36 Survey, Health related quality of life, rotational acetabular osteotomy
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Godinho Bordone Pires, Wrgelles, Roberto Zambelli De Almeida Pinto, Philipe Eduardo Carvalho Maia, Rodrigo Simões Castilho, Felipe Daniel Vasconcelos de Carvalho, and Fernando Araújo Silva Lopes. "PO 18194 - Functional and quality of life assessment of patients with ankle ulcers treated with complete Achilles tendon resection." Scientific Journal of the Foot & Ankle 13, Supl 1 (November 11, 2019): 40S. http://dx.doi.org/10.30795/scijfootankle.2019.v13.1028.
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Objective: The objective of this study is to perform a functional and quality of life assessment of patients subjected to debridement of ulcers in the posterior region of the ankle, which progressed to complete Achilles tendon resection without any type of tendon reconstruction or transfer. Methods: This is a case series of 4 patients, mostly diabetic, who underwent complete resection of an exposed and degenerated Achilles tendon due to ulcer in the posterior region of the ankle that precluded preservation given the need to control the infectious process considering the diagnosis of calcaneal osteomyelitis. This diagnosis was compatible with changes observed in the magnetic resonance imaging evaluation and was confirmed in cultures of bone tissue removed during debridement. The patients filled out the Brazilian Portuguese version of the Achilles Tendon Total Rupture Score (ATRS-BR) and 36-Item Short Form Survey (SF-36) during the postoperative period, and follow-up ranged from 6 to 24 months. The ATRS score ranges from 0 to 100, and the higher the scores are, the fewer symptoms and limitations the patients have. The SF-36 consists of 36 questions covering 8 domains: physical role functioning, physical functioning, bodily pain, general health perceptions, social role functioning, vitality, mental health and emotional role functioning. The items are independently assessed, and the total possible score is 100 points, which is indicative of the best health status. Results: All 4 Achilles tendons were approached. The mean age of the patients was 69.8 years. The mean score on the physical functioning section of the SF-36 was 63.8 points. When comparing the outcome with literature data, we observed that when patients with ulcers were compared with individuals of a similar age group, our study showed better results than previous studies. The mean score of the ATRS-BR was 46.3 points, which suggests a poor outcome. However, the patients had few complaints about their physical functioning, as shown in the SF-36 analysis. The decision not to perform Achilles tendon reconstruction was made jointly by the medical team and the patients and their families. Conclusion: Not reconstructing the Achilles tendon in patients, mostly elderly diabetic patients with posterior ankle ulcers, led to encouraging functional scores. The present study suggests that this type of ulcer treatment is a viable option for such populations.
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Schmader, Kenneth E., Myron J. Levin, Katrijn Grupping, Sean Matthews, David Butuk, Michael Chen, Mohamed El Idrissi, et al. "The Impact of Reactogenicity After the First Dose of Recombinant Zoster Vaccine on the Physical Functioning and Quality of Life of Older Adults: An Open-Label, Phase III Trial." Journals of Gerontology: Series A 74, no. 8 (September 25, 2018): 1217–24. http://dx.doi.org/10.1093/gerona/gly218.
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Abstract Background Herpes zoster and its related complications are associated with significant medical burden, which negatively affects quality of life and daily functioning of the patients. The recently licensed recombinant zoster vaccine (RZV) offers high efficacy but is associated with local and systemic reactions. This study assessed the impact of RZV on the quality of life and daily functioning of participants and implications for caregivers. Methods Four hundred and one adults aged 50 years or older received single RZV doses at 0 and 2 months in this open-label, single-arm, multicenter study (NCT02979639). Change in mean SF-36 Physical Functioning score following first-dose administration, quality of life, reactogenicity, safety, productivity loss, and health care resource utilization was assessed. The current analysis was performed post-vaccine dose-1; safety follow-up will continue until 1 year post-dose-2. Results The most common solicited local symptoms were injection-site pain (77.5%), redness (23.0%), and swelling (13.3%); the most frequent solicited systemic reactions were fatigue (33.5%), headache (28.3%), and myalgia (26.8%). Grade 3 reactogenicity occurred in 9.5% of participants and was associated with a transient clinically important decrease in SF-36 Physical Functioning score (affecting activities such as walking, carrying groceries, climbing stairs) on Days 1 and 2 post-first vaccination. No clinically meaningful reductions in mean SF-36 Physical Functioning scale scores from pre- to post-RZV dose-1 were observed (mean +1.9 points, primary end point), and no overall quality-adjusted-life-year loss was recorded post-dose-1. Five participants reported lost workdays; caregiver workload was not increased. Conclusions Overall, the physical functioning and quality of life of older adults were not affected by a first RZV dose. The observed reactogenicity was consistent with previous studies.
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Porter, John B., Donald Bowden, Arnold Ganser, Gabor Domokos, Adam Gater, Jean-François Baladi, and Maria Domenica Cappellini. "Improved Health-Related Quality of Life in Patients with Hematological Disorders Receiving Deferasirox (Exjade®)." Blood 112, no. 11 (November 16, 2008): 1307. http://dx.doi.org/10.1182/blood.v112.11.1307.1307.
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Abstract Introduction: Iron chelation therapy (ICT) is essential in removing excess iron deposited in body organs, ultimately preventing organ failure and extending the lives of patients (pts) with transfusion-dependent hematological disorders such as β-thalassemia and myelodysplastic syndromes (MDS). As a life-long treatment, traditional ICT (deferoxamine, Desferal®, DFO) is based on a burdensome regimen (subcutaneous delivery 5–7 times a week) that has been shown to negatively impact on pts’ health-related quality of life (HRQoL). The oral chelator deferasirox (Exjade®) is less burdensome to pts offering 24-hour ICT, 7 days a week. Methods: This substudy was part of a single arm, multicenter, 1-year open-label trial (the EPIC study) to investigate the efficacy/safety of deferasirox. The first 558 pts with a variety of hematological disorders were recruited. These pts came from sites in seven countries: Australia, Belgium, France, Germany, UK, Greece, and Italy. Treatment-naïve pts and those having previously received ICT (DFO or deferiprone [Ferriprox®] exclusively, or combined) participated (n=558). Pts were asked at baseline, week 4 and week 52 (end of study [EOS]) to complete the 36-item Short Form health survey (SF-36). The SF-36 is a self-administered questionnaire and measures eight HRQoL domains: physical functioning; role-physical; bodily pain; general health; vitality; social functioning; role-emotional; and mental health. Mean change in SF-36 domain scores were calculated for all pts who had completed data at baseline and week 4, as well all those with completed data at baseline and EOS. All domains are scored so that higher scores indicate a better QoL. Results: Overall, the mean age of the 558 pts (274 β-thalassemia, 168 MDS, 50 sickle cell disease and 66 other anemias) recruited to take part in this substudy was 40.8 years (SD=22.58); 51.5% of patients (n=289) were male and 48.5% (n=272) were female. Within this sample, 337 pts aged ≥16 years completed the SF-36 at baseline, 322 at week 4 and 277 at EOS. Mean domain scores for pts at baseline, week 4 and EOS are presented in Table 1. With the exception of role-emotional (mean=0.78, SD=40.56), mean change in SF-36 domain scores significantly improved (P<0.05) for all domains between baseline and week 4: physical functioning (mean=2.42, SD=17.44); role-physical (mean=5.67, SD=41.70); bodily pain (mean=5.96, SD=24.15); general health (mean=0.33, SD=14.44); vitality (mean=2.54, SD=15.93); social functioning (mean=2.51, SD=23.38); mental health (mean=1.98, SD=14.71). At EOS, mean change in SF-36 domain scores improved for all domains with the exception of social functioning, role-emotional and mental health. However, unlike results at week 4, none of the mean change domain scores at EOS reached statistical significance, possibly due to sample size decrease between week 4 and EOS. Table 1. SF-36 domain scores at baseline, week 4 and EOS in pts aged 3 16 years and treated with deferasirox SF-36 domains Baseline mean (SD) Week 4 mean (SD) End of study mean (SD) Physical functioning 66.32 (25.98)
 n=336 69.70 (25.98)
 n=317 71.67 (26.95)
 n=275 Role-physical 54.33 (42.43) n=331 61.03 (42.69) n=315 62.38 (41.71) n=270 Bodily pain 65.80 (26.89)
 n=336 74.67 (26.16)
 n=322 73.11 (27.20)
 n=276 General health 46.62 (21.15)
 n=330 48.01 (22.32)
 n=311 48.42 (22.19)
 n=269 Vitality 51.12 (21.28)
 n=328 54.57 (22.06)
 n=316 55.80 (23.06)
 n=272 Social functioning 71.73 (25.74)
 n=336 74.77 (23.72)
 n=321 73.05 (24.71)
 n=276 Role-emotional 68.05 (40.92)
 n=326 69.60 (41.60)
 n=313 69.81 (40.44)
 n=270 Mental health 67.04 (19.85)
 n=328 70.40 (19.73)
 n=316 67.85 (20.19)
 n=272 Conclusions: Since mean change scores were often of the magnitude of 3 to 5 units for role-physical and bodily pain, these results indicate clinically meaningful improvement for pts with hematological disorders receiving deferasirox.
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Smaoui, N., I. Lajmi, A. Guermazi, S. Omri, R. Feki, M. Maalej Bouali, N. Charfi, J. Ben Thabet, L. Zouari, and M. Maalej. "Quality of life and mood disorders." European Psychiatry 64, S1 (April 2021): S195. http://dx.doi.org/10.1192/j.eurpsy.2021.517.
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IntroductionMany researches addressing quality of life (QOL) has been demonstrated its impairment during acute episodes of bipolar disorder (BD) and major depressive disorder (MDD).ObjectivesTo compare QOL between patients with remitted MDD and remitted BD and healthy controls (HC).MethodsA comparative and analytical study, conducted over 3 months in the outpatient psychiatric department of Hedi Chaker University Hospital in Sfax (Tunisia) among 30 patients with remitted BD, 30 patients with remitted MDD and 34 HC. QOL was assessed with the «36 item Short-Form Health Survey» (SF-36).Results Compared with HC, the MDD and the BD groups had significantly lower scores for the total of the SF-36 and its sub-domains (table 1). Physical scores were lower in patients with MDD, compared with patients with BD (table 1). Table 1: Comparison of SF-36 sub-domain scores between MDD, BD patients, and HC.Sub-domains of the SF36MDDBDHCPMean physical score - Physical functioning - limitation due to physical health - Pain - General health45.5 67 42.5 60 48.559,28 69,00 44,17 67,13 56,8377,86 84,26 71,03 83,50 72,050.000 0.003 0.005 0.001 0.000Mean psychic score - limitation due to emotional problems - Social functioning - Energy/fatigue - Emotional well-being 47.25 41 55.8 40 5248,19 48.89 43.48 46.5 53.8668,66 76.97 75.52 56.02 66.120,000 0.000 0.000 0.002 0.007Mean global score50.8853,7373,780,000ConclusionsQOL of patients with mood disorders such as MDD and BD suffered damage even in euthymic periods.
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Gülbahar, Selmin, Hüseyin Aydoğmuş, Merve Velioğlu, Ebru Şahin, Hasan Tatari, Halit Pınar, and Elif Akalın. "The Association Between Knee Pain, Symptoms, Function and Quality af Life After Anterior Cruciate Ligament Reconstruction at Short-Term Follow-Up." Orthopaedic Journal of Sports Medicine 2, no. 11_suppl3 (November 1, 2014): 2325967114S0018. http://dx.doi.org/10.1177/2325967114s00182.
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Objectives: To investigate the associations between pain, symptoms, function and knee-related quality of life (QOL) after ACL reconstruction at short-term follow-up Methods: Twenty patients who had undergone ACL reconstruction were included in the study. Knee Injury and Osteoarthritis Outcome Score-Turkish (KOOS-T) was used to evaluate knee pain, other symptoms (symptoms), activities of daily living and sport and recreation (Sport/Rec). Quality of life was assessed with Short Form (SF)-36. Lysholm knee scoring scale was used for clinical evaluation. Results: The mean age of patients was 28. 2 ± 5.5 and the mean time passed after surgery was 38.22 ± 24.7 weeks. A significant correlation (p<0, 05) was found between KOOS-T pain, activities of daily living subscales and all SF-36 subscale scores and both physical component and mental component summary scores. KOOS symptoms and Sports/Rec subscales were correlated with physical and social functioning subscale scores and mental component summary scores of SF-36. Symptoms subscale was also correlated with vitality subscale of SF-36. There was no correlation between SF-36 scores and age and time passed after surgery. Lysholm score was also correlated with most of the subscales of SF-36 but especially with physical component summary score. Conclusion: The QOL of patients who had undergone ACL reconstruction was significantly correlated with pain and activities of daily living. The mental health subscales of SF-36 also correlated with pain, symptoms, ADL and Sports/Rec suggesting that apart from the physical impairment, mental health is also an important clinical issue in patients who had undergone ACL reconstruction.
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Plotkin, Scott Randall, Vanessa L. Merker, Miriam A. Bredella, Wenli Cai, Ara Kassarjian, Gordon J. Harris, Alona Muzikansky, et al. "Relationship between whole-body tumor burden and quality of life in patients with neurofibromatosis." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 6136. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6136.
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6136 Background: NF1, NF2, and schwannomatosis are a group of related genetic disorders in which affected individuals share the predisposition to develop multiple nerve sheath tumors. While previous studies have investigated the relationship between cutaneous tumor burden and quality of life, the relation between internal tumors and quality of life is unknown. Methods: As part of an IRB-approved research study, we performed whole-body MRI and administered the short form (SF)-36 to 245 adult subjects with NF. The number and location of internal nerve sheath tumors in each patient was identified by a board-certified radiologist and tumor volume was calculated using semi-automated volumetric analysis. One sample t-tests were used to compare subjects’ SF-36 scores to general population means. Independent linear regression analyses controlling for age and gender effects were used to relate whole-body tumor count, volume, and distribution (via Gini coefficient) to each domain of the SF-36. Results: 245 patients (142 with NF1, 53 with NF2, 50 with schwannomatosis) completed the study. On the SF-36, subjects with NF1 showed reduced quality of life in the physical role, emotional role, and mental health domains compared to the normal population (p<0.05). Subjects with NF2 showed reductions in the physical functioning, physical role, general health, and social functioning domains while subjects with schwannomatosis showed reductions in the physical role and bodily pain domains (p<0.05). In linear regression analysis, increased tumor number, increased tumor volume, and decreased Gini coefficient were correlated with decreased physical functioning in patients with NF2 (p<0.01). There was also a trend for increasing tumor volume to be correlated with decreased physical role and increased bodily pain in patients with NF1 and with increased bodily pain in patients with schwannomatosis (p<0.10). Conclusions: In our multi-institutional cohort, patients with all forms of neurofibromatosis show selected deficits in quality of life. Internal tumor burden does not correlate with these deficits, with the exception of physical function in NF2 patients.
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Strand, V., P. J. Mease, A. Deodhar, J. Ye, M. Nowak, J. Choi, and B. Becker. "AB0886 The Impact of Deucravacitinib on Health-Related Quality of Life Measured by the Short Form Health Survey 36-Item Questionnaire: Analysis of a Phase 2 Trial in Patients With Active Psoriatic Arthritis." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1567.1–1567. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1283.
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BackgroundPatients (pts) with psoriatic arthritis (PsA) experience pain, loss of physical function, joint damage, and significant impairments in social and emotional well-being. The Short Form Health Survey 36-item questionnaire (SF-36v2), a generic measure of pt-reported health-related quality of life (HRQOL), includes 36 items and measures 8 domains—physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role-emotional (RE), and mental health (MH)—that contribute to both physical component summary (PCS) and mental component summary (MCS) scores. Deucravacitinib (DEUC) is a novel, oral, selective, allosteric inhibitor of tyrosine kinase 2 (TYK2), an intracellular kinase that mediates cytokine signalling pathways implicated in PsA pathogenesis. In a Phase 2 trial in pts with active PsA, DEUC was well tolerated and significantly more efficacious than placebo (PBO) after 16 weeks (wks) of treatment.1ObjectivesTo further evaluate the effect of DEUC treatment on SF-36 scores.MethodsThis double-blind Phase 2 trial (NCT03881059) enrolled pts with a PsA diagnosis ≥6 months who fulfilled Classification Criteria for Psoriatic Arthritis at screening and had active joint disease (≥3 tender and ≥3 swollen joints), high-sensitivity CRP ≥3 mg/L, and ≥1 plaque psoriasis lesion (≥2 cm). Pts failed or were intolerant to ≥1 nonsteroidal anti-inflammatory, conventional synthetic DMARD, and/or 1 TNF inhibitor (≤30%). Pts were randomised 1:1:1 to DEUC 6 mg once daily (QD) or 12 mg QD, or PBO. Changes from baseline (BL) in SF-36 PCS and MCS scores at Wk 16 were prespecified key secondary and additional endpoints, respectively. The 8 SF-36 domain scores were evaluated at Wk 16. The proportions of pts reporting improvements ≥2.5 and ≥5 points (the minimum clinically important difference [MCID]) in SF-36 summary and domain scores, respectively, were evaluated.ResultsOf 203 pts randomised, 180 (89%) completed 16 wks of treatment (DEUC 6 mg QD, 63/70 [90%]; DEUC 12 mg QD, 59/67 [88%]; PBO, 58/66 [88%]). Demographic and BL disease characteristics were similar across groups. BL mean SF-36 PCS and MCS scores were similar among DEUC 6 mg QD, 12 mg QD, and PBO groups (PCS: 34.0, 34.5, and 33.4; MCS: 45.4, 46.9, and 47.5, respectively). At Wk 16, adjusted mean changes from BL in SF-36 PCS and MCS scores were significantly improved with DEUC 6 and 12 mg QD treatment vs PBO (PCS: 5.6, 5.8, and 2.3; MCS: 3.6, 3.5, and 0.7, respectively; P<0.05). Reported improvements in domain scores with both doses exceeded MCID and were significant in 5 of 8 domains with DEUC 6 mg QD (PF, RP, BP, VT, and SF) and 6 of 8 domains with DEUC 12 mg QD (RE in addition; Figure 1 and Table 1).Table 1.Improvements reported in SF-36 domains with deucravacitinib 6 mg QD and 12 mg QD vs placebo at Week 16PFRPBPGHVTSFREMHDeucravacitinib 6 mg – BL41.942.932.539.639.057.069.558.4Deucravacitinib 12 mg – BL44.146.033.438.543.065.571.559.2Placebo – BL42.442.831.740.338.863.875.159.9Deucravacitinib 6 mg – LSM Wk 1614.612.315.99.511.713.26.98.1Deucravacitinib 12 mg – LSM Wk 1613.313.519.58.412.110.58.78.2Placebo – LSM Wk 163.35.37.06.24.2-0.21.63.6Protocol A/G norms81.181.972.570.259.185.188.076.2Domain scores range from 0-100, with higher scores indicating better health status.A/G, age/gender; BL, baseline; BP, bodily pain; GH, general health; LSM, least square mean change; MH, mental health; PF, physical functioning; QD, once daily; RE, role-emotional; RP-role-physical; SF, social functioning; SF-36, Short Form-36; VT, vitality; Wk, week.ConclusionPts with PsA treated with DEUC reported clinically meaningful and significant improvements in HRQOL, including fatigue, social functioning and role emotional in addition to physical functioning, role physical and pain, at Wk 16.References[1]Mease PJ et al. Efficacy and Safety of Selective TYK2 Inhibitor, Deucravacitinib, in a Phase 2 Trial in Psoriatic Arthritis. Ann Rheum Dis. (In Press)AcknowledgementsThe study was sponsored by Bristol Myers Squibb. Professional medical writing assistance from Julianne Hatfield, PhD was provided by Peloton Advantage, LLC, an OPEN Health company, Parsippany, NJ, USA, and funded by Bristol Myers Squibb.Disclosure of InterestsVibeke Strand Consultant of: AbbVie, Amgen, BMS, Boehringer Ingelheim, Celltrion, Galapagos, Gilead, Janssen, Lilly, Merck, Novartis, Pfizer, Rheos, Samsung, Sandoz, Sun Pharma, UCB., Philip J Mease Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Janssen, Novartis, Pfizer, SUN Pharma, UCB, Grant/research support from: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, GlaxoSmithKline, Janssen, Novartis, Pfizer, SUN Pharma, UCB, Atul Deodhar Consultant of: Consulting and/or advisory boards: AbbVie, Amgen, Aurinia, Bristol Myers Squibb, Eli Lilly, GlaxoSmithKline, Janssen, MoonLake, Novartis, Pfizer, and UCB, Grant/research support from: AbbVie, Eli Lilly, GlaxoSmithKline, Novartis, Pfizer, UCB, June Ye Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Miroslawa Nowak Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Jiyoon Choi Shareholder of: Employee of Bristol Myers Squibb at time of study conduct, Employee of: Employee of Bristol Myers Squibb at time of study conduct, Brandon Becker Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb
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Nizov, A. A., V. N. Abrosimov, Anna N. Vyunova, and I. B. Ponomareva. "Evaluation of the quality of life in patients with chronic obstructive pulmonary disease in combination with cardiovascular disease." Clinical Medicine (Russian Journal) 95, no. 7 (August 4, 2017): 629–33. http://dx.doi.org/10.18821/0023-2149-2017-95-629-633.
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This article reports the results of evaluation of the quality of life in patients with chronic obstructive pulmonary disease (COPD) and its combination with coronary heart disease (CHD) or essential hypertension (HD) based on the SF-36 questionnaire designed for the non-specific assessment of the patient's quality of life and widely used in clinical studies to characterize theirgeneral well-being and the degree of satisfaction with those aspects of human activity that affect health. SF-36 consists of 36 questions, grouped into eight scales: physical functioning, role-playing activity, bodily pain, general health, vitality, social functioning, emotional well-being and mental health. The scales are combined in such a way that the higher the value (from 0 to 100) the better results of evaluation based on a given scale. They were used to derive two parameters characterizing psychological and physical components of health.
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Shublaq, Marcia, Marco Orsini, and Marzia Puccioni-Sohler. "Implications of HAM/TSP functional incapacity in the quality of life." Arquivos de Neuro-Psiquiatria 69, no. 2a (April 2011): 208–11. http://dx.doi.org/10.1590/s0004-282x2011000200013.
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OBJECTIVE: To identify the functional status and quality of life of HAM/TSP patients. METHOD: We evaluated prospectively 30 HAM/TSP patients (20 females) seen in the Neuroinfection Clinic of the HUGG. The functional capacity was analyzed by the functional independence measure (FIM), the expanded disability status (EDSS) scale and the Osame's motor disability score (OMDS). The quality of life was assed by the Short-Form Health Survey 36 (SF-36)TM. RESULTS: All patients need assistance device. The FIM, OMDS and EDSS scores classified 70%, 67% and 67% of the patients as dependent, respectively. The lowest scores of the SF-36 survey were found in the domains related to the physical health (D1, D2), role-emotional functioning (D7) and social functioning (D6). CONCLUSION: Our data suggest that the HAM/TSP physical impairment has an impact in the emotional and social issues, considering the limitation in the daily activities.
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Wohlgemuth, Safonova, Engelhardt, Freitag, Wölfle, and Kirchhof. "Improvement of the quality of life concerning the health of patients with peripheral arterial disease (PAD) after successful bypass surgery." Vasa 37, no. 4 (November 1, 2008): 338–44. http://dx.doi.org/10.1024/0301-1526.37.4.338.
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Background: To test whether quality of life depends on the psyche of patients after successful bypass surgery for peripheral arterial disease (PAD). Patients and methods: A total of 74 consecutive patients aged 36–69 years (57.7 ± 8.8 years) with symptomatic PAD in the stages Fontaine IIb–IV were enrolled in a prospective study after successful bypass surgery. Because of bypass failure and one death during the study period, 11 of these patients were excluded from evaluation. Prior to surgery, Doppler sonography and digital subtraction angiography were carried out in all patients. Before and after revascularization, the ankle / brachial index (ABI) was determined in all study objects and the pain free walking distance (PFWD) in those with PAD stage Fontaine IIb. Health-related quality of life was measured by using the "Medical Outcomes Study Group Short Form 36" (SF-36), and personality was determined by employing the Psycho-Diagnostic-Test (PDT). Results: After surgery, there was an increase in ABI from 0.32 ± 0.13 to 0.79 ± 0.19 (p < .01), in PFWD from 42.6 m ± 38.6 m to 419.7 m ± 152.3 m (p < .01), and in the SF-36 scales "Physical functioning", "Bodily pain", "General health perceptions", and "Role-functioning physical" (p < .05). ABI correlated positively with "Bodily pain" (p < .01), "General health perceptions" (p < .01) and "Mental health" (p < .05). Among SF-36 and PDT-scales, "Role-functioning physical" correlated negatively with "Moodiness" / "Neuroticism" (p < .05), and "Social functioning" correlated positively with "General activity" (p < .01). Conclusions: Whether objective clinical improvement increases quality of life mainly depends on the psyche of patients: A high level of general activity favors an improved quality of life and neurotic characteristics are more likely to be a hindrance.
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Malka, Iris, and Iacob Hanțiu. "The Influence of Harmonic Gymnastics on Flexibility, Dynamic Balance, Health and Well-Being of Older Adults: A Pilot Research." Studia Universitatis Babeş-Bolyai Educatio Artis Gymnasticae 65, no. 4 (December 30, 2020): 67–80. http://dx.doi.org/10.24193/subbeag.65(4).32.
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ABSTRACT. Background. Physical activity (PA) is highly recommended for older adults in order to improve physical functioning, health and well-being. Aims. The purposes of this pilot research were: to investigate the influence of Harmonic Gymnastics (HG) on flexibility, dynamic balance, health and well-being of older adults, and to verify the feasibility of the research tools. Methods. In this pilot research 15 healthy men and women, mean age 58.7 (6.5), from Tel Aviv, Israel, volunteered to participate in the research program, which included 50 min. of HG practice, three times a week, for six weeks. Three questionnaires – SF-36 Health and quality of life questionnaire, The Global Physical Activity Questionnaire (GPAQ) and the Mindfulness Awareness Assessment Scale (MAAS) – and two physical skills testing equipment – Y Balance Test (YBT) and the Back Saver Sit and Reach test (BSSR) – were used to assess the subjects. Results. Post-test results showed significant improvements of total score of health and well-being by SF-36 (p < 0.05) and body awareness by MAAS (p <0.0001), but no significant results for SF-36 (0.0629) subscales nor for the global PA measured by GPAQ (p= 0.391). Participants improved hamstring flexibility (p < 0.05) and dynamic balance of right leg (p < 0.001) and left leg (p = 0.00001). Conclusions. This pilot research indicates the feasibility of YBT, BSSR, MAAS and SF-36. HG was found to be tailored for older adults. Older adults improved functioning capabilities, body awareness, health and well-being after the program.