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1

Parkhurst, David L. User's guide to PHREEQC: A computer program for speciation, reaction-path, advective-transport, and inverse geochemical calculations. Lakewood, Colo: U.S. Dept. of the Interior, U.S. Geological Survey, 1995.

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2

L, Parkhurst David. User's guide to PHREEQC (version 2): A computer program for speciation, batch-reaction, one-dimensional transport, and inverse geochemical calculations. Denver, Colo: U.S. Department of the Interior, U.S. Geological Survey, 1999.

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3

J, Appelo C. A., and Geological Survey (U.S.), eds. User's guide to PHREEQC (version 2): A computer program for speciation, batch-reaction, one-dimensional transport, and inverse geochemical calculations. Denver, Colo: U.S. Geological Survey, 1999.

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4

Parkhurst, David L. User's guide to PHREEQC: A computer program for speciation, reaction-path, advective-transport, and inverse geochemical calculations. Lakewood, Co: U.S. Geological Survey, 1995.

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5

Parkhurst, David L. PHREEQE: A computer program for geochemical calculations. Reston, Va: U.S. Geological Survey, 1990.

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6

Jones, Phree. Words of Phree. CreateSpace Independent Publishing Platform, 2013.

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7

Falck, W. E. Two Modified Versions of the Speciation Code PHREEQE for Modelling Macromolecule-proton/cation Interaction. European Communities / Union (EUR-OP/OOPEC/OPOCE), 1991.

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8

Naeem, Muhammad. Microprocessor based phree-phase PWM inverter. Bradford, 1988.

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9

Quilters of The Bunco Club: Phree & Rosa. Frame Masters, Ltd., 2014.

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10

Phrenic neural output during hypoxia: Constant flow ventilation (CFV) vs spontaneous breathing. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1992.

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11

Rafferty, Gerrard, and John Moxham. Assessment of Peripheral and Respiratory Muscle Strength in ICU. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0047.

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Skeletal muscle weakness affecting the respiratory and peripheral muscles is common in critically ill patients and can lead to difficulties in weaning, prolonged ICU admission, and significant morbidity in survivors. A number of techniques can be used to assess muscle strength. In the peripheral muscles, volitional techniques employing scoring systems or portable hand dynamometers are relatively simple and quick to use, requiring little or no specialist equipment. Such techniques can, however, only be applied to conscious and cooperative patients, preventing assessment of muscle weakness in many ICU patients. The volitional requirement also limits the ability to distinguish poor motivation and impaired cognition from true loss of muscle function. Non-volitional techniques involving motor nerve stimulation provide measures of muscle force production in non-cooperative patients but require specialist equipment. Normative data for comparative purposes are limited. Also, it is not clear which peripheral muscle best reflects generalized muscle weakness. Measurements of maximal inspiratory and expiratory pressures are widely used to assess respiratory muscle strength in ICU patients and are applicable to patients who can make some respiratory effort. As with all tests requiring patient cooperation, reliability is limited. Phrenic nerve stimulation allows direct, non-volitional assessment of diaphragm and phrenic nerve function, and normative values for comparative purposes are available. Magnetic phrenic nerve stimulation is well tolerated, can be performed in the presence of vascular catheters, and is used to document respiratory muscle weakness and track progression in critically ill patients.
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12

Lin, Yue. A study of the feedback regulation of neurotransmitter release from the Sprague-Dawley rat phrenic nerve. 1994.

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13

Shaibani, Aziz. Dyspnea. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199898152.003.0009.

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The most common causes of dyspnea are not neuromuscular but rather are cardiac and pulmonary. However, dyspnea is an important and serious manifestation of many neuromuscular disorders, and it may compound an underlying pulmonary or cardiac problem. The diaphragm is a skeletal muscle under the control ofperipheral nerves(phrenic nerves) and may be targeted by inflammatory neuropathies such as Guillain-Barrésyndrome(GBS), chronic inflammatory demyelinating polyneuropathy(CIDP), and brachial plexitis, myopathies such as acid maltase deficiency and muscular dystrophies, and neuromuscular disorders such as myasthenia gravis. Periodic measurement of pulmonary function isrecommended in neuromuscular clinics.
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14

Katirji, Bashar. Case 16. Edited by Bashar Katirji. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603434.003.0020.

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Neuralgic amyotrophy is a relatively uncommon disorder but important to recognize since it may be confused with brachial plexopathy, cervical radiculopathy and entrapment/compressive mononeuropathies of the upper extremity. Neuralgic amyotrophy is also known as acute brachial neuritis, acute brachial plexitis, and Parsonage-Turner syndrome. This case highlights the variable clinical and electrodiagnostic findings encountered in patients with neuralgic amyotrophy, with special attention to the most common mononeuropathies affected in this disorder. This include the long thoracic nerve, axillary nerve, phrenic nerve and anterior interosseous nerve. The peculiar needle electromyography findings associated with neuralgic amyotrophy, including selective motor branch involvement, are also discussed.
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15

Pitt, Matthew. More advanced techniques. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198754596.003.0012.

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This chapter covers some of the less common, more advanced techniques which will be demanded of the paediatric electromyographer. Diaphragmatic function can be assessed by phrenic nerve studies with, on occasion, additional information from diaphragmatic electromyography (EMG) approached from the transcostal route. Tests of cranial nerves are covered including blink reflexes, and studies that can be used for the investigation of swallowing and sucking abnormalities. Also discussed are investigations for abnormalities of the face including congenital facial palsy either acquired congenitally or when it is acquired outside of the neonatal period. The chapter concludes with a section on the EMG investigation of obstetric brachial plexus palsy.
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16

Selim, Bernardo, and Kannan Ramar. Beyond positive airway pressure therapy: experimental and non-conventional treatments in sleep apnoea. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0259.

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With decreased adherence to positive airway pressure therapy to treat sleep apnoeas, non-conventional treatments based on new therapeutic targets are emerging. In central sleep apnoea syndrome associated with heart failure, phrenic nerve stimulation and non-conventional pharmacological treatments such as carbonic anhydrase inhibitors, gas therapies, and cardiac devices are novel alternative therapies. In obstructive sleep apnoea, a better understanding of predominant pathophysiological pathways is characterizing diverse clinical phenotypes. For patients with low arousal threshold, sedatives or hypnotics might be effective, whereas for those with unstable ventilatory control, carbonic anhydrase inhibitors or oxygen might improve obstructive sleep apnoea. For patients with upper airway muscle dysfunction, an increase in pharyngeal tone might be beneficial. This chapter describes ‘experimental’ therapies and novel technologies to treat these disorders.
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17

Sindelar, Richard. Breathing Pattern and Lung Mechanics During Assisted Ventilation: Response of Slowly Adapting Plumonary Stretch Receptors and Effects on Phrenic Nerve ... from the Faculty of Medicine, 1043). Uppsala Universitet, 2001.

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18

Vassilakopoulos, Theodoros, and Charis Roussos. Respiratory muscle function in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0077.

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The inspiratory muscles are the diaphragm, external intercostals and parasternal internal intercostal muscles. The internal intercostals and abdominal muscles are expiratory. The ability of a subject to take one breath depends on the balance between the load faced by the inspiratory muscles and their neuromuscular competence. The ability of a subject to sustain the respiratory load over time (endurance) depends on the balance between energy supplied to the inspiratory muscles and their energy demands. Hyperinflation puts the diaphragm at a great mechanical disadvantage, decreasing its force-generating capacity. In response to acute increases in load the inspiratory muscles become fatigued and inflammed. In response to reduction in load by the use of mechanical ventilation they develop atrophy and dysfunction. Global respiratory muscle function can be tested using maximum static inspiratory and expiratory mouth pressures, and sniff pressure. Diaphragm function can be tested by measuring the transdiaphragmatic and twitch pressures developed upon electrical or magnetic stimulation of the phrenic nerve.
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19

Alolah, Abdulrahman Ib. Microprocessor controlled three-phase inverter for variable-speed induction motor drive: Development of a microprocessor based logic system for the control of the operation of a three phase, neutral point clamped inverter used to control the speed of a phree-phase induction motor. Bradford, 1986.

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