Dissertations / Theses on the topic 'Phosphoproteins'
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Marciniak, Stefan John. "Phosphoproteins of the zymogen granule membrane." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243154.
Full textPoulain, Fabienne. "Stathmin family phosphoproteins and neuronal morphogenesis." Paris 6, 2007. http://www.theses.fr/2007PA066492.
Full textSheppard, Vonda Chantal. "Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37227.
Full textLei, Xia. "Identification and characterization of endosomal specific phosphoproteins." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28483.
Full textStaubli, Justin Charles. "Development of a phosphoprotein enrichment method to identify and characterize phosphoproteins within leukemia following treatment with the PP2A activator, FTY720." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338269265.
Full textChen, Zhaoyuan. "Development of Methods for the Study of Phosphoproteins." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1629.pdf.
Full textGoswami, Suranjana. "IDENTIFICATION OF PHOSPHOPROTEINS INVOLVED IN SPERM MATURATION AND FERTILITY." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532952768427828.
Full textSheehan, M. A. "Phosphoproteins in malignant and non-malignant human-human cell hybrids." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355800.
Full textRothman, Deborah Maria. "Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32429.
Full textVita.
Includes bibliographical references.
Within cellular signaling, protein phosphorylation is the post-translational modification most frequently used to regulate protein activity. Protein kinases and phosphoprotein phosphatases generate and terminate these phosphoryl signals, respectively. Chemical approaches for studying protein phosphorylation and the roles of phosphoproteins include photolabile caged analogs of bioactive species. Caged compounds are ideal chemical probes for studying cellular signaling because they afford researchers spatial and temporal control over the release of targeted effector molecules. Ligands or proteins involved in signal transduction can be chemically caged and subsequently irradiated to release a concentration burst of a specific species, allowing the downstream effects to be monitored without disrupting other aspects of the system. The syntheses and applications of caged phosphopeptides and phosphoproteins have been developed and detailed within this thesis. Two methods to synthesize 1-(2-nitrophenyl)ethyl caged phosphopeptides were developed. These peptides demonstrated good quantum yields of uncaging as compared to literature values of other ortho-nitrobenzyl derived caged compounds. A study in which these caged phosphopeptide tools yielded seminal information about the 14-3-3 protein family's involvement in cell cycle control successfully demonstrated the unique utility of these probes. Furthermore, the synthesis that allowed the extension of the nonsense codon suppression methodology to include caged phosphoproteins was developed.
(cont.) The three most commonly phosphorylated amino acids (serine, threonine, and tyrosine) were each incorporated into a test protein in their caged phosphorylated form. Toward studying cell motility, caged phosphoserine was incorporated into position 153 of mVASP for use in live cell assays.
by Deborah Maria Rothman.
Ph.D.
Neubauer, Gitte Jackie. "Microcharacterisation of multi-protein complexes and phosphoproteins by nanoelectrospray mass spectrometry." Thesis, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299339.
Full textZitzmann, Sabine. "In-situ-Analysen des exocytosesensitiven Phosphoproteins PP63/Parafusin in Paramecium-Zellen." [S.l.] : Universität Konstanz , Fakultät für Biologie, 1998. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8214570.
Full textClifford, Gary. "The translocation of hormone-sensitive lipase and perilipin during lipolysis." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285397.
Full textZhang, Yun. "Activation of Erk1/2 and Akt in astrocytes under ischemia /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202002%20ZHANGY.
Full textIncludes bibliographical references (leaves 98-115). Also available in electronic version. Access restricted to campus users.
Pekar, Tonya M. "Phosphoproteomic studies of smooth muscle contraction investigation of differential phosphorylation in relaxed/contracted rat aortic smooth muscle tissue using MALDI-TOF MS /." Huntington, WV : [Marshall University Libraries], 2003. http://www.marshall.edu/etd/descript.asp?ref=370.
Full textTitle from document title page. Document formatted into pages; contains xv, 148 p. including illustrations. Includes bibliographical references (p. 131-148).
Ali, S. M. "The role of phosphoproteins during development and memory formation in the chick." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383569.
Full textLaverdure, Guy R. J. "Growth factor regulation of a 69kDa phosphoprotein secreted by NRK- -49F cells." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59535.
Full textTreatment of NRK-49F cells with insulin, EGF, TGF-$ beta$, PPA, levamisole and spermine clearly demonstrate alterations in the phosphorylation of pp69, concomitant with changes in extracellular phosphatase activity.
Kalita, Ann Marie. "Comparison of the activities of two allelic variants of the human wildtype p53 protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29729.pdf.
Full textNemir, Mohamed. "Inhibition of osteopontin expression in mammary epithelial cells alters mammary gland morphogenesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0020/NQ44529.pdf.
Full textShanmugam, Vijayalakshmi. "Characterization of osteopontin in RSV transformed rat-1 cells and its role in cell transformation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0005/NQ37025.pdf.
Full textNaor, Naftaly. "The immune response against p53 protein in cancer patients /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69652.
Full textLee, Wai-him, and 李偉謙. "Proteomic analysis of protein phosphorylation in PC12 cells induced bypituitary adenylate cyclase activating polypeptide 38." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B30149885.
Full textWalker, Valerie Glynis. "Pl3-kinase mediates cSrc activation and podosome formation through the adaptor protein, AFAP-110, in response to PKC[alpha] activation." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5191.
Full textTitle from document title page. Document formatted into pages; contains viii, 306 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Wenzel, Jens [Verfasser], and Thomas [Gutachter] Rudel. "Regulation of TLR-induced macrophage responses by cytoskeleton-associated phosphoproteins / Jens Wenzel. Gutachter: Thomas Rudel." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1108780806/34.
Full textBroncel, Malgorzata [Verfasser]. "Synthetic phosphopeptides and phosphoproteins as tools for studying peptide and protein self-assembly / Malgorzata Broncel." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025552814/34.
Full textAl-Mokhtar, Ruby. "Identification of the FERM domain containing proteins moesin, radixin and ezrin as insulin-regulated phosphoproteins." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528102.
Full textVogel, Elizabeth Maura. "Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38621.
Full textVita.
Includes bibliographical references.
Protein phosphorylation is a central regulatory mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are limited in providing temporal information. As a complement to these techniques, the synthesis and semisynthesis of probes that enable researchers to observe the downstream effects of kinase-mediated phosphorylation in "real time" are presented in this thesis. The release of a physiologically-relevant concentration of a phosphopeptide with temporal and spatial control is accomplished by the photolysis of a photolabile precursor, a caged phosphopeptide. The synthesis and application of NI-Fmoc-protected 1-(2-nitrophenyl) ethyl (NPE) caged phosphothreonine, serine, and tyrosine building blocks facilitate the straightforward assembly of any caged phosphopeptide through Fmoc-based solid phase peptide synthesis. Removal of the NPE caging group by irradiation with long-wavelength UV light generates a concentration burst of the corresponding phosphopeptide. In addition, the installation of a caged phosphoamino acid into a full-length, multi-domain protein, the cellular migration protein paxillin, is described. A strategy, which is applicable to any expressible protein target, is detailed for the semisynthesis of a paxillin variant with a caged phosphorylated tyrosine at residue 31 of the 557-residue protein using native chemical ligation.
(cont.) Paxillin is a 61-kDa protein known to orchestrate the interaction of signaling proteins involved in cell migration by acting as a molecular adaptor, with the creation of specific binding sites dependent on paxillin phosphorylation. Therefore, the semisynthetic probe comprises the entire paxillin macromolecule, including all other binding and localization domains, which are essential for creating a native-like system to probe the effect of phosphorylation. The comprehensive biochemical characterization of the paxillin probe and quantification of uncaging following irradiation with long-wavelength UV light are also described. Additionally, the strategy developed for the paxillin semisynthesis was applied to incorporate a different unnatural amino acid, the fluorescent chemosensing residue Sox, into a protein-domain sensor for ERK2 kinase activity. The protein domain sensor demonstrated significantly improved sensitivity for ERK2 phosphorylation over the corresponding peptide probe.
by Elizabeth Maura Vogel.
Ph.D.
Brännström, Kristoffer. "Molecular dissection of established and proposed members of the Op18/Stathmin family of tubulin binding proteins /." Umeå : Univ, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1949.
Full textBarker, Sharon. "The intracellular localization of mammalian DNA ligase I." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23986.
Full textPhippen, Taryn Marie. "Mechanisms of Hairy-mediated transcriptional repression during Drosophila development /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5059.
Full textSneesby, Kyra, and n/a. "Gene Expression in Embryonic Chick Heart Development." Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030924.153514.
Full textSneesby, Kyra. "Gene Expression in Embryonic Chick Heart Development." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367647.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Dädelow, Judith. "Elektronenmikroskopische Studien zur Immunlokalisation des listeriellen Oberflächenproteins ActA sowie seines zellulären Bindungspartners, des Vasodilator-stimulated Phosphoproteins (VASP) /." [S.l. : s.n.], 1999. http://www.gbv.de/dms/bs/toc/302594450.pdf.
Full textFrost, Laura Stephanie. "Characterisation of the Mitotic Golgi Phosphoproteins, TATA Modulatory Factor(TMF) and Zinc Finger Protein-Like 1 (ZFPL1)." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503762.
Full textLabbé, Etienne. "Temperature-modulation of protein phosphorylation in cell-free extracts of alfalfa." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ44093.pdf.
Full textKarlsson, Margareta. "Caveolae in insulin signalling in human and rat adipocytes /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med782s.pdf.
Full textElzi, David John. "Transcriptional properties of the Kaiso class of transcription factors /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5027.
Full textRenström, Frida. "Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes /." Umeå : Department of Public Health and Clinical Medicine, Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1078.
Full textJohnstone, Mary O. "Characterization of soluble matrix from molluscan shell with an emphasis on two major phosphoproteins from the Eastern oyster, Crassostrea virginica." Connect to this title online, 2008. http://etd.lib.clemson.edu/documents/1211398553/.
Full textGaraguso, Ignazio [Verfasser]. "Development of MALDI-TOF mass spectrometry based methods for the identification and molecular characterization of proteins, phosphoproteins and DNA adducts / Ignazio Garaguso." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1019723939/34.
Full textKawczyński, Wojciech. "Effects of low temperature on nuclear proteins of alfalfa." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23278.
Full textWe show that the phosphorylation level of several nuclear proteins is subject to rapid and reversible enhancement by low temperature. Several phosphoproteins were found to be constitutively present in the nucleus of both cultivars. The cold-induced stimulation of the phosphorylation of many of these proteins was much greater in the relatively freezing tolerant cultivar Apica than in the relatively freezing sensitive cultivar Trek. Population of nuclear phosphoproteins was found to be considerably more complex in Apica than in Trek. During a prolonged exposure of the seedlings to 4$ sp circ$C, additional phosphoproteins were imported into the nucleus of Apica seedlings but not those Trek.
Some heat-stable proteins were constitutively present in the nucleus of both cultivars. However during the 4-day cold treatment, a large accumulation of several additional heat-stable proteins was observed in the tolerant, but not the sensitive, cultivar. (Abstract shortened by UMI.)
Chitta, Karnakar Reddy. "Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygenspecies and phosphorylated proteins." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367942581.
Full textRussell, Tanya D. "PAT protein regulation of cytoplasmic lipid droplet formation and secretion : role of adipophilin in mammary epithelial cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.
Find full textTypescript. Includes bibliographical references (leaves 134-149). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Ghafouri, Bijar. "Proteomics of the upper airways : studies on a new lipopolysaccharide-binding protein, PLUNC /." Linköping : Dept. of Molecular and Clinical Medicine, Linköping University, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med927s.pdf.
Full textJenkins, Mark 1979. "A role for the Drosophila eIF4E binding protein during stress response /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82256.
Full textThe Drosophila forkhead transcription factor dFOXO is a transcriptional activator of d4E-BP. There is a strong reduction of d4E-BP peptide in a dFOXO null background. dFOXO null flies are also sensitive to oxidative stress, and rescue of this sensitivity through ectopic expression of UAS-d4E-BP(wt) in a dFOXO null background suggests d4E-BP is a downstream mediator of dFOXO oxidative stress resistance.
Stenkula, Karin. "A molecular approach to insulin signalling and caveolae in primary adipocytes /." Linköping : Univ, 2006. http://www.bibl.liu.se/liupubl/disp/disp2007/med977s.pdf.
Full textSparks, Cynthia A. "Cloning and Cell Cycle Analysis of NuMA, a Phosphoprotein That Oscillates Between the Nucleus and the Mitotic Spindle." eScholarship@UMMS, 1995. https://escholarship.umassmed.edu/gsbs_diss/35.
Full textThurfjell, Niklas. "p63 - from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck /." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-998.
Full textСеменина, Іванна Петрівна. "Отримання кальцієвмісних природних харчових функціональних інгредієнтів." Thesis, Тернопільський національний технічний університет імені Івана Пулюя, 2017. http://elartu.tntu.edu.ua/handle/123456789/19306.
Full textIn thisgraduation degree for extracting phosphopeptidesfrom the products of proteolysisof total casein,their selective precipitation with Са2+ ions and alcohols is suggested. By the result of gel filtration it was established thatnatural calcium-containingphosphopeptides that may be used as functional food ingredients are formed with using ethanol.
Bennett, Clare Suzanne. "Characterisation of secreted phosphoprotein 24." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/30334.
Full textSweet, Steve M. M. "Phosphoprotein analysis by mass spectrometry." Thesis, University of Manchester, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538385.
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