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Relevant bibliographies by topics / Phenotype Microarray / Dissertations / Theses

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Dissertations / Theses on the topic 'Phenotype Microarray'

Author: Grafiati

Published: 10 March 2023

Last updated: 25 July 2025

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1

Wennmalm, Kristian. "Analytical strategies for identifying relevant phenotypes in microarray data /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-401-3/.

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2

Sjödin, Andreas. "Populus transcriptomics : from noise to biology /." Umeå : Department of Plant Physiology, Umeå University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1423.

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3

Mok, Bobo. "Genomic and transcriptomic variation in blood stage Plasmodium falciparum /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-291-0/.

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4

Martínez, Enguita David. "Identification of personalized multi-omic disease modules in asthma." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15987.

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Asthma is a respiratory syndrome associated with airflow limitation, bronchial hyperresponsiveness and inflammation of the airways in the lungs. Despite the ongoing research efforts, the outstanding heterogeneity displayed by the multiple forms in which this condition presents often hampers the attempts to determine and classify the phenotypic and endotypic biological structures at play, even when considering a limited assembly of asthmatic subjects. To increase our understanding of the molecular mechanisms and functional pathways that govern asthma from a systems medicine perspective, a compu

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5

Rösel, Anja [Verfasser], and Frank [Akademischer Betreuer] Pessler. "Application of the Biolog Phenotype MicroArray TM to study changes in host cell metabolism during influenza A virus infection / Anja Rösel ; Akademischer Betreuer: Frank Peßler ; Institut für Experimentelle Infektionsforschung des Twincore Zentrum für Experimentelle und Klinische Infektionsforschung." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://nbn-resolving.de/urn:nbn:de:gbv:354-2017061613.

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6

Rösel, Anja [Verfasser], and Frank [Akademischer Betreuer] Peßler. "Application of the Biolog Phenotype MicroArray TM to study changes in host cell metabolism during influenza A virus infection / Anja Rösel ; Akademischer Betreuer: Frank Peßler ; Institut für Experimentelle Infektionsforschung des Twincore Zentrum für Experimentelle und Klinische Infektionsforschung." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2017. http://d-nb.info/1135490783/34.

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7

Turton, Nicola. "Association of gene expression and genomic change, analysed using microarrays, with phenotype in breast carcinoma." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/30770.

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Breast cancer is the commonest malignancy to affect women and approximately 1 in 9 women (12 %) will develop the disease in developed countries (Burstein and Winer 2000). A major problem for treatment is the development of a drug resistant phenotype, whereby the tumour fails to respond to chemotherapy. This phenotype arises from altered gene expression in the resistant cells, which can occur by changes in transcription and/or genomic alteration. Other phenotypic properties of breast carcinoma cells may also arise in this way, and gene expression profiles can be linked to different breast tumou

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8

Yahaya, Badrul H. "Analysis of time-dependent transcriptomic and phenotypic changes associated with repair and regeneration in the airway epithelium." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4800.

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The airway epithelium demonstates the ability to quickly repair following physical injury. The morphologic features of this dynamic repair process have been well characterised at the anatomic and cellular level using a number of animal model systems and these studies have provided a solid foundation upon which our understanding of normal repair is build. With the advent of molecular and bioinformatic tools and resources the opportunity exists to extend the value of these models in defining the molecular pathways and interactions that underlay the normal repair process. This thesis represents a

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9

Shaffer, Justin P., Jana M. U'Ren, Rachel E. Gallery, David A. Baltrus, and A. Elizabeth Arnold. "An Endohyphal Bacterium (Chitinophaga, Bacteroidetes) Alters Carbon Source Use by Fusarium keratoplasticum (F. solani Species Complex, Nectriaceae)." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/623193.

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Bacterial endosymbionts occur in diverse fungi, including members of many lineages of Ascomycota that inhabit living plants. These endosymbiotic bacteria (endohyphal bacteria, EHB) often can be removed from living fungi by antibiotic treatment, providing an opportunity to assess their effects on functional traits of their fungal hosts. We examined the effects of an endohyphal bacterium (Chitinophaga sp., Bacteroidetes) on substrate use by its host, a seed-associated strain of the fungus Fusarium keratoplasticum, by comparing growth between naturally infected and cured fungal strains across 95

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10

Roberge, Christopher (Christopher M. ). "Design, manufacture, and application of DNA microarrays to study gene expression phenotypes of lysine-producing Corynebacterium glutamicum." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32322.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references (leaves 197-213).<br>Corynebacterium glutamicum partial genome DNA microarrays were constructed that were capable of assaying the transcriptional profile of the genes of pathways involved in central carbon metabolism and lysine biosynthesis. It was found that to ensure arrays of high quality, protocols applying the arrays should include DNase treatment of RNA samples. additional RNA filtration purification steps, and the use of gene specific primers in the formati

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11

Ghadiali, Alifiya H. "Studies on Mycobacterium avium subsp. paratuberculosis genotypic and phenotypic variations /." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1110229469.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Document formatted into pages; contains xxi, 216 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2006 March 9.

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12

Wong, Chieh Lee. "Identification of unique genetic and epigenetic signatures in myeloproliferative neoplasms using microarray and next generation sequencing : association with MPN-related mutations and clinical phenotypes." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/52714.

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The past decade has witnessed significant progress in the understanding of the molecular pathogenesis of myeloproliferative neoplasms (MPN). Mutations in a large number of genes have now been implicated in the pathogenesis of MPN but their relative importance, the mechanisms by which they cause different cells to predominate and differentiate into the separate MPN syndromes and their implications for prognosis remain unknown. I hypothesized that other genes and epigenetic mechanisms may contribute to the pathogenesis of the different disease subtypes at a cell-type specific level. This study f

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13

Bouchiat, Coralie. "Facteurs bactériens impliqués dans la survenue de l’endocardite infectieuse au cours d’une bactériémie à Staphylococcus aureus." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10187.

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L'endocardite infectieuse (EI) est une complication rare mais gravissime de la bactériémie à Staphylococcus aureus. Bien que certains facteurs de risque liés à l'hôte aient été décrits, l'implication de facteurs bactériens dans la survenue de l'EI est encore inconnue. Ces travaux de thèse ont visé à chercher tout élément bactérien associé à l'EI. Les facteurs phénotypiques décrits ou supposés comme potentiellement impliqués dans l'EI ont été testés. En parallèle, les profils génotypiques des souches obtenus par puces ADN ont été analysés par différents outils statistiques. L'analyse statistiqu

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14

Hebrant, Aline. "Pathologies thyroïdiennes et modèles in vitro: profils d'expression génique et phénotypes moléculaires." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210139.

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La thèse s’inscrit dans un projet de recherche global visant à caractériser les tumeurs thyroïdiennes sur le plan moléculaire, afin de mieux comprendre leur physiopathologie et afin d’identifier des biomarqueurs (signatures moléculaires) qui pourront être utilisés pour le diagnostic, le pronostic et leur traitement. Parmi celles-ci, nous distinguons les adénomes autonomes (AA) et folliculaires (FTA) tumeurs bénignes encapsulées, et les carcinomes, tumeurs malignes. Ceux-ci sont eux-mêmes subdivisés en carcinomes différenciés, folliculaires (FTC) ou papillaires (PTC), et peuvent évoluer en carc

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15

Stojakovic, Milica. "Role of the CD40 receptor/CD154 ligand dyad in the control of smooth muscle cells phenotype." Doctoral thesis, 2003. http://hdl.handle.net/11858/00-1735-0000-0006-AB93-0.

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16

Yip, Cindy Ying Yin. "Pathology of Calcific Aortic Valve Disease: The Role of Mechanical and Biochemical Stimuli in Modulating the Phenotype of and Calcification by Valvular Interstitial Cells." Thesis, 2010. http://hdl.handle.net/1807/26520.

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Calcific aortic valve disease (CAVD) occurs through multiple mutually non-exclusive mechanisms that are mediated by valvular interstitial cells (VICs). VICs undergo pathological differentiation during the progression of valve calcification; however the factors that regulate cellular differentiation are not well defined. Most commonly recognized are biochemical factors that induce pathological differentiation, but little is known regarding the biochemical factors that may suppress this process. Further, the contribution of matrix mechanics in valve pathology has been overlooked, despite increas

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17

Bellabarba, Agnese. "Into the wild: how rhizobia compete and survive in the early stage of symbiosis." Doctoral thesis, 2022. http://hdl.handle.net/2158/1280999.

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Associations between leguminous plants and symbiotic nitrogen-fixing bacteria (rhizobia) are a classic example of mutualism between a eukaryotic host and a specific group of prokaryotic microbes. Rhizobia improve plant yield furnishing fixed nitrogen; therefore, they are highly used as inoculants, especially in sustainable agriculture. Though this association is species-specific, legume roots are exposed to heterogeneous rhizobial populations where different compatible strains are present and, could be infected by more than one strain. It is known that within the same rhizobial species differe

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18

Narayanaswamy, Rammohan 1978. "Genome-wide analyses of single cell phenotypes using cell microarrays." Thesis, 2008. http://hdl.handle.net/2152/3967.

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The past few decades have witnessed a revolution in recombinant DNA and nucleic acid sequencing technologies. Recently however, technologies capable of massively high-throughout, genome-wide data collection, combined with computational and statistical tools for data mining, integration and modeling have enabled the construction of predictive networks that capture cellular regulatory states, paving the way for ‘Systems biology’. Consequently, protein interactions can be captured in the context of a cellular interaction network and emergent ‘system’ properties arrived at, that may not have been

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19

Lin, Wen-Ting. "Systematic data preprocess procedures and factor extraction of multiple phenotypes for one-color microarray." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1607200415331300.

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20

Lin, Wen-Ting, and 林雯婷. "Systematic data preprocess procedures and factor extraction of multiple phenotypes for one-color microarray." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/22547434483964753647.

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碩士<br>國立臺灣大學<br>工業工程學研究所<br>92<br>Microarrays are widely used to monitor gene expressions to yield information for genomes. Though there are many methods and mechanisms proposed to extract information from microarray data, the preprocess of raw expression data determine the accuracy and reliability of the extracted information. The first objective of this research is to implement a systematic procedure to preprocess the raw intensity reading. The proposed data preprocess procedure has 3 steps: rectification of intensity reading, signal normalization and bad spots screening. The rectification o

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21

Niu, Wei. "Development of imaging-based high-throughput genetic assays and genomic evaluation of yeast gene function in cell cycle progression." Thesis, 2007. http://hdl.handle.net/2152/3606.

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Systems biology studies the complex interactions between components of biological systems. One major goal of systems biology is to reconstruct the network of interactions between genes in response to normal and perturbed conditions. In order to accomplish this goal, large-scale data are needed. Accordingly, diverse powerful and high-throughput methods must be developed for this purpose. We have developed novel high-throughput technologies focusing on cellular phenotype profiling and now provide additional genome-scale analysis of gene and protein function. Few high-throughput methods can perfo

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22

Gupta, Kuldeepkumar Ramnaresh. "(p)ppGpp and c-di-GMP : A Tale of Two Second Messengers in Mycobacterium smegmatis." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/4117.

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Nucleotide based second messengers are known to regulate wide variety of processes in all domains of life. Two such bacterial second messengers are (p)ppGpp (guanosine tetra- or pentaphosphate) and c-di-GMP (cyclic dimeric guanosine monophosphate). The alarmone (p)ppGpp is synthesized by bacteria to face any kind of stress; while the signalling nucleotide c-di-GMP is synthesized principally to switch from motile (planktonic) to sessile (biofilm) life style. Apart from mediating the said functions, these nucleotides also regulate transcription, translation, replication, virulence and pathogenic

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23

Brito, Lauro David Silva de. "Determining the functional interactions of inducers/inhibitor compounds in controlling the ramA locus in Klebsiella pneumoniae." Master's thesis, 2012. http://hdl.handle.net/10400.1/11028.

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Nas últimas décadas, as bactérias multiresistentes tornaram-se numa das principais ameaças à saúde global, desenvolvendo mecanismos e estratégias para ultrapassar os mais recentes avanços da ciência. A família das Enterobacteriaceae conta com vários exemplos de espécies multiresistentes, entre as quais a espécie Klebsiella pneumoniae, um patogénio nosocomial oportunístico, causador de infecções associadas aos cuidados de saúde, com grande capacidade de adaptação a diferentes ambientes e resistência a um grande leque de terapias. Estes agentes patogénicos adquirem resistência das mais variadas

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24

Συμεωνίδη, Διονυσία. "Βιοπληροφορική ανάλυση και χαρακτηρισμός γονιδίων που εμπλέκονται στη φαινοτυπική πλαστικότητα του zebrafish (Danio rerio, Hamilton 1822)". Thesis, 2011. http://hdl.handle.net/10889/5366.

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Η θερμοκρασία ανάπτυξης αποτελεί παράγοντα μεγάλης σημασίας στην οντογένεση των ιχθύων, αφού ως ποικιλόθερμοι οργανισμοί είναι συνεχώς εκτεθειμένοι στις μεταβολές του περιβάλλοντός τους. Έχει παρατηρηθεί πως η θερμοκρασία ανάπτυξης δύναται να προκαλέσει μετατόπιση του χρονοδιαγράμματος των οντογενετικών γεγονότων και πλαστικότητα σε μορφολογικούς και φυσιολογικούς χαρακτήρες (πχ στο μυοσκελετικό και το καρδιαγγειακό σύστημα). Ωστόσο, μέχρι σήμερα δεν έχει μελετηθεί η επίδραση της θερμοκρασίας ανάπτυξης στο πρότυπο της γονιδιακής έκφρασης του zebrafish και σκοπός της παρούσας εργασίας είναι η μ

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25

(10725786), James Michael Amstutz. "Cluster-Based Analysis Of Retinitis Pigmentosa Candidate Modifiers Using Drosophila Eye Size And Gene Expression Data." Thesis, 2021.

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<p>The goal of this thesis is to algorithmically identify candidate modifiers for <i>retinitis pigmentosa</i> (RP) to help improve therapy and predictions for this genetic disorder that may lead to a complete loss of vision. A current research by (Chow et al., 2016) focused on the genetic contributors to RP by trying to recognize a correlation between genetic modifiers and phenotypic variation in female <i>Drosophila melanogaster</i>, or fruit flies. In comparison to the genome-wide association analysis carried out in Chow et al.’s research, this study proposes using a K-Means clustering algor

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