Dissertations / Theses on the topic 'Phenanthroline'
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Ott, Sascha M. "Acetylenic phenanthroline analogues, phenanthrolino-fused benzodehydrannulenes and their Ru(II)-complexes." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271653.
Full textBoone, Lindsay Leighton. "The highly preorganized ligands 1,10-Phenanthroline-2,9-Dialdoxime and BIS-1, 10-Phenanthroline, and their complexing properties with metal ions /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/boonel/lindsayboone.pdf.
Full textRais, Daniela. "Supramolecular chemistry of metal anynyl and metal phenanthroline complexes." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271988.
Full textBetancourt, Daniel. "Copper bis(phenanthroline) complexes as simple models for molecular transducers." Tallahassee, Fla. : Florida State University, 2008. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/368250.
Full textAdvisor: Dr. Kenneth Goldsby, Florida State University, College of Arts and Sciences, Dept. of Chemistry and Biochemistry. Includes bibliographical references.
Shemesh, Ely 1962. "TERNARY COMPLEXES OF COPPER(I), CYANIDE, AND 2,9-DIMETHYL-1,10-PHENANTHROLINE." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291268.
Full textDe, Kavita. "Applications of fluoro-alcohols as reaction media for the synthesis of heterocyclic compounds and perspectives in the design of hybrid materials." Paris 11, 2010. http://www.theses.fr/2010PA114821.
Full textLes alcools fluorés comme l’hexafluoroisopropanol (HFIP) et trifluoroéthanol (TFE) possède des propriètes uniques (aptitude à former des liasons hydrogène, une faible nucléophilie, un fort pouvoir ionisant et un faible pKa) qui sont très differents de celles de leur analogues hydrogénés. Grace à leur propriètes, les alcools fluorés peuvent promouvoir des réactions differentes. Nous avons montré que HFIP est un solvant efficace pour réaliser la réaction de Ferrier. Le 3,4,6-Tri-O-acétyl glucal a réagi avec alcools différents pour donner des glucosides 2,3-insaturés. Ainsi nous avons étudié la réaction d’addition d’amines aromatiques sur les accepteurs de Michael dans les solvants polaires protiques. Nous avons ainsi démontré que la réaction d’aza-Michael des amines aromatiques pouvait être promue et contrôlée par simple effet de ces solvants. Selon la nature du solvant et de l'électrophile, la sélectivité de la réaction peut être affinée pour mener des produits de mono-ou di-addition ou même quinoléines selon une cascade d’addition/cyclialkylation/déshydratation. Nous avons montré que HFIP et TFE sont des solvants très efficaces pour la synthèse de la 8-aminoquinoléines par une séquence Povarov/oxydation, à partir des réactifs simples (1,2-phénylènediamines, aldéhydes et éthers vinyliques). Une deuxième séquence Povarov/oxydation donne des phénanthrolines substitués à position C-2 ou C-9. Les phénanthrolines synthétisés ont été étudiés en tant que ligands dans deux réactions différents: i) clivage oxydatif de C=C (double liaison carbone-carbone) catalysée par AuCl; ii) le couplage oxydatif de Heck catalysée par Pd(OAc)2. Vu la demande croissante de la chimie verte, nous avons synthétisé de nouveaux matériaux décorés avec des fractions HFIP pour servir comme catalyseurs récupérables. Malheureusement, les études préliminaires ne sont pas encourageantes et aucun effet catalytique significatif n’a été observé dans les réactions de sulfoxydation, d'ouverture d’époxyde par des amines aromatiques, la réaction d’aza-Michael avec des amines aromatiques et la réaction de Ferrier. D'autre part, nous avons envisagé que, en raison de la présence du groupement HFIP, le matériau hybride organique-inorganique pourrait former des liaisons hydrogène avec certains groupements fonctionnels présents dans des principes actifs, et pourraient donc trouver des applications en tant que transporteur de médicaments. Dans une étude préliminaire, le nouveau matériau a montré une adsorption importante d'acides carboxyliques
Eggers, Friederike [Verfasser]. "2,9-Diaryl-1,10-phenanthroline für molekulare Erkennung, Metallo- und Organokatalyse / Friederike Eggers." Kiel : Universitätsbibliothek Kiel, 2008. http://d-nb.info/101955343X/34.
Full textReck, Lisa Maria [Verfasser]. "Enantiomerenreine konkave 1,10-Phenanthroline - Liganden für die enantioselektive Metallkatalyse / Lisa Maria Reck." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1053653549/34.
Full textGaeva, Elena B. "Thermal equilibrium, photochromism and acidicromism of some spirooxazines of phenanthroline and naphtalene." Toulouse 3, 2006. http://www.theses.fr/2006TOU30086.
Full textMerocyanines derive from the spiro bond cleavage of photochromic spirooxazines. Although merocyanines are generally unstable, appropriate conditions can stabilize them. Two series of spirophenanthrolinoxazines and spironaphthoxazines bearing the O-Alk chain in position 5 have been studied. According to their structures, different techniques allow to open the spiroform and to stabilize the merocyanine. For spirooxazines of phenanthroline series, the merocyanine content raises significantly with the solvent polarity. For spironaphthoxazines, protonation turns the solution red and negative photochromism has been observed under visible light irradiation. Numerical modelling has been applied to analyse the recorded data within the two series. Several interesting photochromic parameters have been determined. The investigated properties have great potential applications for future specific sensors or logic elements
Huesgen, Brian. "Structure and synthesis of four supramolecular structures involving Cu(I) and 4,7-phenanthroline." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4965.
Full textThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed Oct. 26, 2007). Vita. Includes bibliographical references.
Edwards, Alyn. "The development of 1,10-phenanthroline-derived extractants for advanced future nuclear fuel cycles." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-development-of-110phenanthroline-derived-extractants-for-advanced-future-nuclear-fuel-cycles(50b1ff9e-9cc5-4252-9769-0a949858a80c).html.
Full textBose, Rakesh. "Amperometric detection of aldosterone by high-performance liquid chromatography with copper(II) bis-phenanthroline /." Connect to online version, 1995. http://hdl.handle.net/1989/3553.
Full textWang, Siwen. "Development of Novel Phenanthroline and Thiazole Orange Derived G-quadruplex Ligands and Telomerase Inhibitors." Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3167.
Full textDean, Nolan Edward. "Metal ion complexing properties of the highly preorganized ligand 1, 10-phenanthroline-2,9-dicarboxylic acid /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-3/deann/nolandean.pdf.
Full textStührenberg, Kai [Verfasser]. "Phenanthroline-based copper complexes for water splitting applications : photo-physical and spectroscopic investigations / Kai Stührenberg." Paderborn : Universitätsbibliothek, 2017. http://d-nb.info/1149721782/34.
Full textDjomgoue, Paul. "N3, N4/(N3S, N3O) and N6 Phenanthroline Bases and their Spin Crossover Iron(II) Complexes." Doctoral thesis, Universitätsbibliothek Chemnitz, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-207498.
Full textDie vorliegende Dissertation behandelt die Synthese von Eisen(II)-Komplexen und ihr spin crossover (SCO)-Verhalten. Das Gleichgewicht zwischen high-spin (HS)- und low-spin (LS)-Zustand verleiht den SCO-Systemen eine großes Anwendungspotential im Bereich der molekularen Elektronik. Dennoch existiert bis heute kein SCO-basiertes molekulares Bauteil auf dem Markt. Hauptgrund hierfür ist, dass die bislang bekannten SCO-Systeme keine hinreichenden Eigenschaften (z.B. TLIESST « 300 K) aufweisen. Das Ziel der vorliegenden Arbeit ist die Synthese neuer SCO-Verbindungen mit geeigneten Eigenschaften für die Anwendung. Zu Beginn der Arbeit werden die Komplexe [Fe(rac-22a)]2+∙2[BF4]– und [Fe(rac-22b)]2+ ∙2[BF4]– mit starren hexadentaten Liganden beschrieben. Entgegen der Erwartung verschiebt die N-Methylierung der Amine das Gleichgewicht in Richtung des LS-Zustandes. Verglichen mit dem nicht-methylierten Komplex Fe(rac-22b)]2+∙2[BF4]– zeigt Fe(rac-22a)]2+∙2[BF4]– eine höhere Übergangstemperatur T1/2, welche in Nitrobenzen 74 K und in Acetonitril 52 K beträgt. Für die Komplexe ist T1/2 lösungsmittelabhängig. Im Folgenden wurde die Ligandenserie 9-R2-2-(6-R1-pyridin-2-yl)-1,10-phenanthrolin mit den Vertretern 25b (R2= Me), 25f (R2 = Ph), 25d (R2 = C(O)H, 25c (R1 = Ph), 25l (R1 = oxyphenyl-4-oxymethylen), 25m (R1 = oxymesitylen) und 25j (R1 = pyrol-1-yl) hergestellt. Es wurde beobachtet, dass die Größe des Substituenten das SCO-Verhalten (T1/2) beeinflusst. Ergänzend wurde der Einfluss des Gegenions anhand der Komplexe [Fe(25c)]2+∙2[BF4]– und [Fe(25c)]2+∙2[B(Ph)4]– untersucht. Das Gegenion B(Ph)4– ermöglicht intra- und intermolekulare π···π-Wechselwirkungen in der Zelle, welche die Übergangstemperature T1/2 (200 K) gegenüber dem BF4–-Komplex (175 K) erhöhen. Des Weiteren beeinflussen die Substituenten R1 an der Pyridin-Einheit die ubergangskomplexes T1/2 stärker als die Substituenten R2 an der Phenanthrolin-Einheit. So ist [Fe(25f)]2+∙2[BF4]– (R1 = Ph) ein reiner HS-Komplex, während der Komplex [Fe(25c)]2+∙2[BF4]– (R2 = Ph) ein SCO-System ist (T1/2 = 175 K). Die Erhöhung der Koordinationszahl von N6 auf N8 wurde über die Synthese von tetradentaten Liganden untersucht. Diese Erhöhung führt zu einem unerwarteten Koordinationsmodus. So bildet [Fe(25i)]2+∙2[BF4]– (R2 = pyrazol-1-yl) eine quadratisch-antiprismatische Koordinationssphäre (HS Eisen(II)-Komplex) und zeigt, wie erwartet, über den untersuchten Temperaturbereich keine Fe–N-Bindungsspaltung
FRANCOIS, JEAN CHRISTOPHE. "Nucleases artificielles specifiques de sequences d'adn et arn : oligodesoxyribonucleotides couples a la 1, 10-phenanthroline." Paris 6, 1989. http://www.theses.fr/1989PA066189.
Full textFROIDEVAUX, JEROME. "Etudes physico-chimiques d'une porphyrine de zinc a chapeau phenanthroline : reconnaissance selective de bases azotees." Université Louis Pasteur (Strasbourg) (1971-2008), 1998. http://www.theses.fr/1998STR13202.
Full textWhitchurch, Christian J. "Development of a Novel Electrochemiluminescent Reaction Involving Cadmium." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1011035988.
Full textGephart, Raymond Thomas. "The highly preorganized ligand 2,9-BIS(Hydroxymethyl)-1,10-Phenanthroline, and its complexation properties with metal ions /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/gephartr/raymondgephart.pdf.
Full textGERMANO, GLEICE CONCEICAO MENDONCA. "STUDY OF INTERACTIONS OF THE ANTIBIOTIC NORFLOXACIN AND ITS COPPER-PHENANTHROLINE COMPLEX WITH DRUG DELIVERY SYSTEMS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2018. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=36049@1.
Full textCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
PROGRAMA DE EXCELENCIA ACADEMICA
Os sistemas de administração controlada de medicamentos (drug delivery) permitem a introdução de uma substância terapêutica no organismo e melhoram sua eficácia e segurança, controlando a taxa, o tempo e o local de liberação, o que diminui os efeitos colaterais.Nesse trabalho nos dedicamos a estudar dois possíveis sistemas de administração de fármacos: lipossomos associados a surfactantes, já bastante utilizados em farmacologia, e nanobastões de ouro, cujas propriedades únicas têm sido avaliadas em aplicações biomédicas. Os lipossomos têm-se destacado devido a sua estabilidade e baixa toxicidade, os surfactantes são tensoativos muito usados tanto em farmacologia como para estabilizar soluções coloidais de nanopartículas. Já os nanobastões de ouro têm perspectivas promissoras para utilização em entrega de fármacos devido a suas propriedades óticas e biocompatibilidade. Estudamos, por meio de espectrofotometria de fluorescência e de absorção UV-visível, a associação entre esses sistemas e uma classe de fármacos denominada fluorquinolonas, que são antibióticos de amplo espectro bacteriano. A norfloxacina (NFX), pertencente à segunda geração de fluorquinolonas, foi escolhida para esse trabalho por ser naturalmente fluorescente, o que facilita a análise das interações sem a introdução de sondas extrínsecas ao sistema. Segundo a literatura, a associação da NFX com íons metálicos produz modificações nas propriedades desse fármaco, como solubilidade e biodisponibilidade. Essas mudanças têm sido avaliadas como uma possível solução ao problema de resistência bacteriana a antibióticos. Esse trabalho foi dividido em duas partes: na primeira, estudamos a formação dos complexos ternários de NFX com cobre-fenantrolina em presença de lipossomos associados a surfactantes que modificam a distribuição de carga elétrica superficial desses sistemas; na segunda parte estudamos a associação de NFX a nanobastões de ouro estabilizados por diferentes surfactantes.
Drug delivery systems allow the introduction of a therapeutic substance into the body and improve its effectiveness and safety by controlling the rate, time and place of release, which reduces side effects. In this work, we study two possible drug delivery systems: liposomes associated with surfactants, which are already widely used in pharmacology, and gold nanorods, whose unique properties have been evaluated in biomedical applications. Liposomes have been remarkable because of their stability and low toxicity, and surfactants are widely used both in pharmacology and to stabilize colloidal solutions of nanoparticles. On the other hand, gold nanorods have promising perspectives for use in drug delivery due to their optical properties and biocompatibility.We study the association between these systems and a class of drugs called fluoroquinolones, which are broadspectrum bacterial antibiotics, using fluorescence spectrophotometry and UVvisible absorption. Norfloxacin (NFX), a second generation fluoroquinolone, was chosen because it is naturally fluorescent, which facilitates the analysis of interactions without the introduction of extrinsic probes into the system. According to the literature, the association of NFX with metal ions produces changes in the properties of this drug, such as solubility and bioavailability. These changes have been evaluated as a possible solution to the problem of bacterial resistance to antibiotics. This work was divided in two parts: first, we studied the formation of the ternary complexes of NFX with copper-phenanthroline in the presence of liposomes associated to surfactants that modify the distribution of surface electric charge of the systems; in the second part, we studied the association of NFX to gold nanorods stabilized by different surfactants.
Hounsou, Sedjro Candide. "Conception, synthèse et études biologiques de nouveaux inhibiteurs de la telomerase." Paris 6, 2004. http://www.theses.fr/2004PA066159.
Full textHuang, Wei. "Structure, electronic, and photophysical properties of platinum(ii) biphenyl complexes containing 2,2’-bipyridine and 1,10-phenanthroline derivatives." Diss., Wichita State University, 2010. http://hdl.handle.net/10057/3649.
Full textThesis (Ph.D.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry
Melton, Darren Landon. "Metal ion complexing properties of the two-dimensional, highly preorganized ligand 1, 10-Phenanthroline-2, 9-Dicarboxylic acid /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/meltond/darrenmelton.pdf.
Full textSalez, Hervé. "Synthèse de dérivés d'acridine et de benzo-(b)-1,7-phenanthroline : étude de leurs propriétés chimiques, physicochimiques et pharmacologiques." Université Joseph Fourier (Grenoble ; 1971-2015), 1991. http://www.theses.fr/1991GRE10171.
Full textTerry, Tracy J. "Immobilized bis-phenanthroline coordination sites in porous silica : characterzation and reactivity of manganese(II) and iron(II) complexes /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Full textListorti, Andrea <1981>. "Copper(I) phenanthroline complexes and supramolecular systems containing fullerenes: Photophysics, photochemistry and potential applications in sustainable energy technologies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1463/1/Listorti_Andrea_tesi.pdf.
Full textListorti, Andrea <1981>. "Copper(I) phenanthroline complexes and supramolecular systems containing fullerenes: Photophysics, photochemistry and potential applications in sustainable energy technologies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1463/.
Full textCockrell, Gregory Mercer. "The highly preorganized ligand 2, 9-DI-(2'-PYRIDYL)-1, 10-Phenanthroline, and its complexation properties with metal ions /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-1/cockrellg/gregorycockrell.pdf.
Full textFouilland, Laura. "Synthesis of novel 1.10-phenanthrolins and cyclic analogs, a potential anticancer and antimalarial agents." Thesis, KTH, Skolan för kemivetenskap (CHE), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-32945.
Full textTidigare studier har indikerat att molekyler med 1,10-phenanthrolineskelett har en skyddande effekt mot malaria och cancer. Syftet med detta projekt är att syntetisera nya 1,10-phenanthrolinar och cykliska analoger. Framställningsmetoden som användes i denna studie har inte undersökts tidigare. Föreningen skapades genom en originalmetod utnyttjande en redoxreaktion med hjälp av en TDAE-reagens. TDAE är en elektronrik organisk molekyl och fungerar som en effektiv reduktionsagent. Med hjälp av en enelektronöverföring (SET) kan en anjon framställas under milda förhållanden utifrån halogena derivat. Anjonen tillförs 1,10-phenanthroline-5,6-dione. De olika substraten är heteroaromatiska nitro-benzyliska och quinoniska derivat, samt bromodifluorometylheteroarylerade. Cykliska produkter erhölls genom en tvåstegsreaktion (reduktion, dehydratisering) genomförd i ett enda reaktionskärl. Med detta projekt har dessa reaktioner för första gången testats på den här typen av molekyler. Det krävs mer optimering eftersom utbytena var låga till medelhöga. Utav sex möjliga substrat fungerade additionsreaktionen med TDAE med fyra stycken. I detta försök testades dock endast en cyklisk reaktion på additionsprodukten. Med ytterligare förbättringar av reaktionsvillkor och upparbetningar förväntas man kunna producera önskad produkt i gott utbyte.
Girardot, Camille. "Synthèses et propriétés en optique linéaire et non linéaire du troisième ordre de complexes de coordination à ligans 5-oligofluorène-phénanthroline." Lyon, École normale supérieure (sciences), 2005. http://www.theses.fr/2005ENSL0345.
Full textBoudot, Clotilde. "Recherche de nouvelles molécules trypanocides." Thesis, Limoges, 2019. http://www.theses.fr/2019LIMO0078.
Full textKinetoplastid diseases are vectorial parasitoses caused by flagellated blood protozoa. Among these, African Trypanosomiasis, due to a parasite of the genus Trypanosoma, affects both humans and animals. In humans, this disease, known as sleeping sickness, progresses classically in 2 stages: the hemolymphatic stage characterized by multiplication of the parasite in blood and lymph and the nervous stage characterized by the presence of the parasite in the brain. In the absence of appropriate therapy, death is inevitable. Currently, the treatments proposed in human and veterinary medicine are old, toxic and at the origin of cases of resistance. The search for new molecules is therefore essential to control this pathology. It is in this context that we studied two families of molecules which recognize parasitic sites: (i) Nitroimidazoles that interact with nitroreductases to generate toxic intermediates, and (ii) Phenanthroline derivatives targeting telomerases to disrupt trypanosome DNA synthesis. Our thesis research evaluated the trypanocidal power of different molecules from these two families both by in vitro tests and in a mouse model infected with a strain of Trypanosoma brucei brucei. The purpose of this work was to identify new drug candidates. The results obtained have made it possible to identify compounds of interest that open up new pathways of research to control this parasite, as well as all kinetoplastidae
Phetxumphou, Katherine. "Consumers and Their Drinking Water: Communicating Water Quality and Assessing the Reaction of Zerovalent Nanoiron (nZVI) with Saliva." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/49260.
Full textMaster of Science
Gaver, Charles Richard. "The highly preorganized ligands 8-(2-Pyridyl) Quinoline, 2,2'-dipyridyl amine and 1,10-phenanthroline-2, 9-dicarboxylic acid, and their complexing properties with metal ions." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-3/gaverc/charlesgaver.pdf.
Full textDjomgoue, Paul [Verfasser], Heinrich [Akademischer Betreuer] Lang, Heinrich [Gutachter] Lang, and Birgit [Gutachter] Weber. "N3, N4/(N3S, N3O) and N6 Phenanthroline Bases and their Spin Crossover Iron(II) Complexes / Paul Djomgoue ; Gutachter: Heinrich Lang, Birgit Weber ; Betreuer: Heinrich Lang." Chemnitz : Universitätsbibliothek Chemnitz, 2016. http://d-nb.info/1214377289/34.
Full textVidal, Pierre-Louis. "Synthèse et caractérisation de ligands polymères conjugués alternant oligothiophènes et complexes de métaux de transition de type bis(1,10-phénanthroline)." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10142.
Full textFernaÌndez, Iglesias Eva. "Liquid-crystalline phenanthrolines." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269721.
Full textFerretti, F. "HOMOGENEOUS CATALYTIC REDUCTIVE CARBONYLATION OF ORGANIC NITRO COMPOUNDS: BIDENTATE NITROGEN LIGANDS AS A KEY POINT." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/214936.
Full textPatel, Mohit Pratish. "OPTIMIZATION AND APPLICATION OF PHOTOLUMINESCENCE- FOLLOWING ELECTRON-TRANSFER WITH TRIS(TETRAMETHYL- 1,10-PHENANTHROLINE) Os/Ru(III) COMPLEXES AND FENTON BASED CHEMILUMINESCENCE DETECTION OF NSAIDS AND DOPAMINE IN BIOLOGICAL SAMPLES." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/385393.
Full textPh.D.
Biogenic monoamines such as dopamine play an important role as major neurotransmitters. Simultaneous determination of the concentration changes is thus crucial to understand brain function. Additionally, quantification of pharmaceutically active compounds (PhACs) and their metabolites in biological fluids is an important issue for forensic tests, clinical toxicology and pharmaceutical analysis. We have developed two postcolumn luminescence detection methods coupled to a 2-dimensional-solid phase extraction (2D-SPE) system. The postcolumn reaction methods used in this study are the redox-dependent photoluminescence-following electron-transfer (PFET) and Fenton-based chemiluminescence techniques, for the determination of certain neurotransmitter and nonsteroidal anti-inflammatory drugs (NSAIDs). A stable [Os(tmphen)3]3+ (tmphen = 3,4,7,8-tetramethyl-1,10-phenanthroline) reagent was prepared in neutral aqueous solution by oxidation of [Os(tmphen)3]2+ with lead(IV) oxide. [Os(tmphen)3]2+ and [Os(tmphen)3]3+ are characterized by absorption spectroscopy. [Os(tmphen)3]3+ stability is compared with [Ru(tmphen)3]3+ in the same pH 7 environment. The properties of Os(III) and Ru(III) complexes were investigated for use as the oxidant in a PFET system. Studies of photophysical and electrochemical properties, the stability of the Os(III) and Ru(III) complexes, and analytical application in PFET detection of oxidizable analytes are presented. The spectroscopic properties of the complexes were not very advantageous, but careful control of the detection system and reaction conditions enabled sensitive detection of the analytes. The method was fully validated and the optimized system was capable of detecting dopamine and acetaminophen at about 30.2 µg L-1 and 33.5 µg L-1, respectively. The limit of detection (LOD) was 1.5 µg L-1 for acetaminophen and 4.3 µg L-1 for dopamine. The accuracy and precision were within bioanalytical method validation limits (90.9 to 101.5 % and RSD < 12.0 %, respectively). Typical analysis time was less than 15 minutes. Two Fenton-based flow-injection chemiluminescence (CL) methods were developed and validated for the determination of naproxen. Under the optimal experimental conditions the proposed methods exhibited advantages in a larger linear range from 2,760 ng mL-1 to 207,000 ng mL-1 for the first CL method and 41.4 ng mL-1 to 700.0 ng mL-1 for the second CL method. The LOD was 13.8 ng mL-1 for naproxen. The CL mechanisms for the system, H2O2-FeIIEDTA-naproxen was further studied by batch experiments, chemiluminescence spectroscopy, fluorometry, high pressure liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). The effects of various interferences commonly found in biological and wastewater systems on the chemiluminescence intensity were also investigated. We used these methods to determine NSAIDs in commercial pharmaceutical formulations. Another application of these method was for detecting NSAIDs in biological samples. A 2x-1-Dimensional Solid Phase Extraction (2x-1D SPE) method was developed for determination of acetaminophen and naproxen in urine. This method uses both the methanol concentration and the pH advantageously to preferentially isolate analytes of interest from complex sample matrix. These methods were fully validated and had sufficient sensitivity (limit of quantification: acetaminophen; 40.41 mg L-1 - 360.0 mg L-1 and naproxen; 23.03 mg L-1 - 214.8 mg L-1) for biological matrices and applications.
Temple University--Theses
Mohan, Kumar Sreelatha Meera. "Synthèse de complexes cuivreux luminescents." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAF068/document.
Full textThe present PhD thesis descibes the preparation of stable Cu(I) complexes through appropriate ligand design to prevent the formation of several species in equilibrium. In the case of dinucleating P,N-ligands, the proposed strategy is based on the use of a ligand with additional substituents to shield the metal centers and thus to prevent nucleophilic attacks leading to ligand dissociation. In the case of the [Cu(NN)(PP)]+ derivatives, the proposed synthetic strategy relies on the use of macrocyclic phenanthroline ligands preventing the formation of the corresponding homoleptic complexes [Cu(NN)2]+. Stable luminescent complexes have been thus prepared, the emission quantum yields being as high as 46% in the solid state for the best emitters
Oliveira, Handerson Silva Venceslau. "Síntese e caracterização de complexos homonucleares e heteronucleares de lantanídeos e bismuto obtidos a partir de citrato de sódio e 1,10-fenantrolina." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/9027.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Homonuclear complexes LnCitnH2O (Ln3+ = Eu3+, Tb3+ and Gd3+) were synthesized by stoichiometric addition of the respective aqueous solutions of the Ln3+ ions under the form nitrate and sodium citrate solution (Na3Cit) at a ratio of 1:1. A complex of formula Bi6O4(OH)4Cit2.2H2O, (M1), was synthesized similarly to the homonuclear complexes Ln3+, wherein the composition obtained was not compatible with the stoichiometry of the starting reactants, i.e., the stoichiometric bismuth/citrate ratio of 1:1. Other bismuth complex, with minima formula BiCit2H2O, (M2), was synthesized by reaction of Na3Cit with Bi(NO3)3 and phen, from the stoichiometric ratio 1:1:1, i.e., citrate, Bi3+ and phen. The complex EuCit.1/2(phen).2H2O (phen = 1,10-phenanthroline) was obtained by reaction between Na3Cit, Eu(NO3)3 and phen with a stoichiometry of the starting reactants in the ratio 1:1:1. Complexes bismuth and lanthanide, heteronucleares, were also synthesized in the ratio 1:1:2, from their respective nitrate salts of Bi3+ and Ln3+ and of the Na3Cit salt. All of these materials were characterized using: atomic graphite furnace absorption spectrophotometry, elemental analysis (CHN), (except for complexes M1 and M2), infrared (IR) spectroscopy and thermal analysis (TG-DTA-DTG). For the EuCit.1/2(phen).2H2O complex, luminescence spectroscopy was also used, which showed high luminescent intensity when irradiated with light of wavelength 350 nm. From the quantitative data of the graphite furnace, elemental analysis (CHN) and thermal analysis techniques, the chemical composition of each complex was suggested and by infrared, coordination forms of the ligands Cit and phen to ions metallics were found. For the heteronuclear complexes, the results of all these techniques indicate structures of the types [LnBi2Cit2.3H2O](H2O)3 ( Ln = Eu3+ and Gd3+ ) and [BiTbCit.2H2O](H2O)3.
Complexos homonucleares LnCit.nH2O (Ln3+ = Eu3+, Tb3+ e de Gd3+ ( n= 1 - 3)) foram sintetizados por adição estequiométrica das respectivas soluções aquosas dos íons de Ln3+, sob a forma nitrato, e da solução de citrato de sódio (Na3Cit), sendo a proporção usada referente às soluções dos reagentes de 1:1. Complexos de bismuto e lantanídeo, heteronucleares, também foram sintetizados a partir dos respectivos sais de nitrato de Bi3+ e Ln3+ e do sal de Na3Cit agora na proporção 1:1:2. Um complexo de fórmula Bi6O4(OH)4Cit2.2H2O, (M1), foi sintetizado de modo semelhante aos dos complexos homonucleares Ln3+, porém, a composição obtida não foi compatível com a estequiometria dos reagentes de partida, ou seja, estequiométrica de 1:1, bismuto / citrato. Outro complexo de bismuto, com fórmula mínima de BiCit.2H2O, (M2), foi sintetizado pela reação de Na3Cit com Bi(NO3)3 e fen, a partir da razão molar 1:1:1, isto é, citrato, ion de bismuto e fen. Também um complexo de európio com composição EuCit.1/2(fen).2H2O (fen = 1,10-fenantrolina) foi obtido pela reação entre Na3Cit, Eu(NO3)3 e fen com uma estequiometria dos reagentes de partida também na proporção de 1:1:1. Todos estes materiais foram caracterizados por: espectrofotometria de absorção utilizando forno de grafite, análise elementar (CHN), (com exceção dos complexos M1 e M2), espectroscopia vibracional na região do infravermelho (FTIR) e análise térmica (TG-DTA-DTG). Para o complexo EuCit.1/2(fen).2H2O espectroscopia de luminescência foi também usada, tendo o mesmo mostrado alta intensidade luminescente quando irradiado com luz de comprimento de onda de 350 nm. A partir dos dados quantitativos de forno de grafite, análise elementar (CHN) e técnicas de análise térmica, a composição química de cada complexo foi sugerida e pelos espectros de infravermelho, as formas de coordenação dos ligantes Cit e fen aos íons metálicos foram também indicadas. Para os complexos heteronucleares, os resultados das três primeiras técnicas indicam estruturas dos tipos [LnBi2Cit2.3H2O](H2O)3 ( Ln = Eu3+ e Gd3+) e [BiTbCit.2H2O](H2O)3.
TUVERI, ROSSANA. "Identification & characterization of natural and synthetic compounds as new anticancer agents." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266770.
Full textKotze, Izak Aldert. "Self-association of [PtII(1,10-Phenanthroline)(N-pyrrolidyl-N-(2,2-dimethyl-propanoyl)thiourea)]+ and non-covalent outer-sphere complex formation with fluoranthene through cation-π interactions : a high resolution 1H and DOSY NMR study." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1796.
Full textShen, Jingyi. "Density functional theory study on the interstitial chemical shifts of main-group-element centered hexazirconium halide clusters; synthetic control of speciation in [(Zr6ZCl12)] (Z = B, C)-based mixed ligand complexes." Diss., Texas A&M University, 2003. http://hdl.handle.net/1969.1/2444.
Full textLima, Ana Karina Castro. "Efeito da 1,10-fenantrolina e seus derivados complexados em metal na atividade proteolítica de Leishmania braziliensis." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4604.
Full textLeishmanioses são um grupo de doenças com um largo espectro de manifestações clínicas, as quais variam desde lesões cutâneas até o envolvimento visceral severo, podendo levar ao óbito. A leishmaniose é, ainda hoje, uma doença negligenciada, estando entre os agravos prioritários do programa de pesquisa sobre doenças da pobreza da Organização Mundial da Saúde (OMS). Além de não haver vacinas disponíveis, a terapia é baseada em medicamentos injetáveis que causam sérios efeitos colaterais, tornando o tratamento inviável para muitos países endêmicos. Drogas derivadas de metal representam um novo arsenal terapêutico antimicrobiano e anti-câncer. Os inibidores de peptidase/agentes quelantes tais como 1,10-fenantrolina e seus derivados, no estado livre de metal ou como ligantes com metais de transição, interferem com a função de vários sistemas biológicos. Em trabalhos anteriores, nosso grupo descreveu que o parasito L. braziliensis produziu moléculas gp63 sensíveis a 1,10-fenantrolina. No presente trabalho, demonstramos a distribuição celular da molécula gp63 em uma cepa virulenta de L. braziliensis por meio de análises bioquímicas e imuno-histoquímica. Depois disso, relatamos os efeitos inibitórios de três compostos derivados da 1,10-fenantrolina, 1,10-fenantrolina-5,6-diona (phendio), [Cu(phendio)2] e [Ag(phendio)2], nas atividades metalopeptidases celulares e extracelulares produzidas por promastigotas de L. braziliensis, bem como as suas ações sobre a viabilidade do parasita e na interação com as células de macrófagos murinos. As moléculas gp63 foram detectadas em compartimentos de parasitos, incluindo membrana citoplasmatica e bolsa flagelar. O tratamento de promastigotas de L. braziliensis durante 1 hora com 1,10-fenantrolina e seus derivados resultou numa inibição significativa da viabilidade celular e mostrou um mecanismo de ação irreversível. Estes inibidores de metalopeptidases induziram apoptose em promastigotas de L. braziliensis, demonstrada através da marcação com anexina/iodeto de propídio e ensaio TUNEL. O pré-tratamento de promastigotas com os inibidores de metalopeptidases induziram uma diminuição na expressão de moléculas de superfície gp63, assim como uma redução significativa no índice de associação com macrófagos. Em paralelo, macrófagos infectados com L. braziliensis e tratados com 1,10-fenantrolina e seus derivados promoveram uma potente redução sobre o número de amastigotas intracelulares. O tratamento de macrófagos com 1,10-fenantrolina e seus derivados não induziram o aumento de óxido nítrico. A ação combinatória sobre a capacidade de crescimento entre os compostos derivados da 1,10-fenantrolina e Glucantime, quando ambos foram utilizados em concentracões sub-inibidoras, também foi observada. In vivo os compostos derivados da 1,10-fenantrolina e seus drivados foram capazes de controlar o tamanho das lesões a partir da terceira semana de tratamento em relação ao controle não tratado em hamsters infectados quando administrado por via intraperitoneal. Os animais tratados com os compostos apresentaram maior resposta intradérmica (DTH) aos antígenos de L. braziliensis. Coletivamente, a 1,10-fenantrolina e seus derivados metálicos apresentam uma nova perspectiva de estudos para o desenvolvimento de novos fármacos anti-L. braziliensis
Leishmaniasis is a group of diseases with a wide spectrum of clinical manifestations, which range from self-limited skin lesions to severe visceral involvement that can lead to death. Leishmaniasis is still a neglected disease, and it is among the priorities of the research program on diseases of poverty of World Health Organization (TDR/WHO). There is no available vaccine and the treatment is based on drugs that cause serious side effects, and are unaffordable in several endemic countries. Metal-based drugs represent a novel antimicrobial and anti-cancer therapeutics arsenal. Peptidase inhibitors/chelating agents such as 1,10-phenanthroline and its substituted derivatives, either the metal-free state or as ligands coordinated to transition metals, interfere with crucial functions of several biological systems. In previous works, our group described that L. braziliensis produced gp63 molecules sensible to 1,10-phenanthroline. Herein, we initially studied the cellular distribution of gp63 in a virulent strain of L. braziliensis by biochemical and immunocytochemical analyses. After that, we reported the inhibitory effects of three 1,10-phenanthroline derivative compounds, 1,10-phenanthroline-5,6-dione (phendio), [Cu(phendio)2]and [Ag(phendio)2], on both cellular and extracellular metallopeptidase activities produced by L. braziliensis promastigotes as well as their actions on the parasite viability and on the interaction with murine macrophage cells. The gp63 molecules were detected in several parasite compartments, including cytoplasm, membrane lining the cell body and flagellum, and flagellar pocket. The treatment of L. braziliensis promastigotes for 1 hour with 1,10-phenanthroline and its derivatives resulted in a significant inhibition of cell viability and showed an irreversible mechanism of action. These metallopeptidase inhibitors induced apoptosis in L. braziliensis promastigotes as judged by annexin/propidium iodide staining and TUNEL assays. The pre-treatment of promastigotes with metallopeptidase inhibitors induced a reduction on the expression of surface gp63 as well as a significant reduction on the association index with macrophages. In parallel, the treatment of L. braziliensis-infected macrophages with the 1,10-phenanthroline and its derivatives promoted a powerful reduction on the number of intracellular amastigotes. The treatment of macrophage cells with 1,10-phenantroline and its derivatives did not induce nitric oxide production. A synergistic inhibition on the growth ability was observed when 1,10-phenanthroline derivative compounds and Glucantime were used at sub-inhibitory concentrations. In vivos the compounds 1,10-phenanthroline derivatives and its were able to control the lesions size from the third week of treatment on, when compared to untreated control infected hamsters. The animals treated with the compounds showed greater response to the intradermal antigens of L. braziliensis. Collectively, the 1,10-phenanthroline and its metal-based drugs present a good perspective for prospective studies to the development of new anti-L. braziliensis drugs
Gueneau, Basile. "Etude et utilisation de complexes polypyridiniques du cuivre (II) dans le cadre de la catalyse de la délignification des pâtes papetières." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENV023.
Full textDioxygen delignification considerably reduces the operating cost of the bleaching process and decreases the environmental impact of the bleaching effluent. Unfortunately the performance of dioxygen delignification is limited since part of the residual lignin is not reactive toward dioxygen while cellulose depolymerisation occurs. Studies suggested that dioxygen delignification could be improved thanks to the use of catalysts such as copper(II)–phenanthroline type complexes which have shown promising results on delignification efficiency. However cellulose was also more degraded. Different polypyridinyl ligands have been studied in this work, in an attempt to find copper(II) complexes that have more affinity toward lignin and less toward cellulose. Complexes have been characterised by UV/Vis spectroscopy, cyclic volammetry, and they were studied for the catalysed oxidation of various substrates: a non phenolic lignin model compound and lignocellulosic substrates (a model of cellulose, a model of native lignin and an industrial kraft pulp). It has been shown that the nature of the ligand had a significant effect on the catalytic activity of Cu(II) complexes in the oxygen oxidation of the lignin model compound. However, the active complexes only show a limited activity during the delignification of a kraft pulp and oxidize carbohydrates. This lack of selectivity prevents from an industrial application for paper pulp production but may be useful for the design of products with fewer constraints on cellulose polymerization degree
Elatawy, M. A. K. "SYNTHESIS OF NITROGEN HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION OF ALPHA, BETA-UNSATURATED NITRO COMPOUNDS, CATALYZED BY PALLADIUM COMPLEXES AND WITH CARBON MONOXIDE AS THE REDUCTANT." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/331319.
Full textCafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Full textCafe, Peter F. "Towards reliable contacts of molecular electronic devices to gold electrodes." University of Sydney, 2008. http://hdl.handle.net/2123/3870.
Full textSYNOPSIS OF THIS THESIS The aim of this thesis is to more fully understand and explain the binding mechanism of organic molecules to the Au(111) surface and to explore the conduction of such molecules. It consists of five discreet chapters connected to each other by the central theme of “The Single Molecule Device: Conductance and Binding”. There is a deliberate concentration on azine linkers, in particular those with a 1,10-phenanthroline-type bidentate configuration at each end. This linker unit is called a “molecular alligator clip” and is investigated as an alternative to the thiol linker unit more commonly used. Chapter 1 places the work in the broad context of Molecular Electronics and establishes the need for this research. In Chapter 2 the multiple break-junction technique (using a Scanning Tunnelling Microscope or similar device) was used to investigate the conductance of various molecules with azine linkers. A major finding of those experiments is that solvent interactions are a key factor in the conductance signal of particular molecules. Some solvents interfere with the molecule’s interaction with and attachment to the gold electrodes. One indicator of the degree of this interference is the extent of the enhancement or otherwise of the gold quantized conduction peak at 1.0 G0. Below 1.0 G0 a broad range for which the molecule enhances conduction indicates that solvent interactions contribute to a variety of structures which could bridge the electrodes, each with their own specific conductance value. The use of histograms with a Log10 scale for conductance proved useful for observing broad range features. vi Another factor which affects the conductance signal is the geometric alignment of the molecule (or the molecule-solvent structure) to the gold electrode, and the molecular alignment is explored in Chapters 3 for 1,10-phenanthroline (PHEN) and Chapter 4 for thiols. In Chapter 3 STM images, electrochemistry, and Density Functional Theory (DFT) are used to determine 1,10-phenanthroline (PHEN) structures on the Au(111) surface. It is established that PHEN binds in two modes, a physisorbed state and a chemisorbed state. The chemisorbed state is more stable and involves the extraction of gold from the bulk to form adatom-PHEN entities which are highly mobile on the gold surface. Surface pitting is viewed as evidential of the formation of the adatom-molecule entities. DFT calculations in this chapter were performed by Ante Bilic and Jeffery Reimers. The conclusions to Chapter 3 implicate the adatom as a binding mode of thiols to gold and this is explored in Chapter 4 by a timely review of nascent research in the field. The adatom motif is identified as the major binding structure for thiol terminated molecules to gold, using the explanation of surface pitting in Chapter 3 as major evidence and substantiated by emergent literature, both experimental and theoretical. Furthermore, the effect of this binding mode on conductance is explored and structures relevant to the break-junction experiment of Chapter 2 are identified and their conductance values compared. Finally, as a result of researching extensive reports of molecular conductance values, and having attempted the same, a simple method for predicting the conductance of single molecules is presented based upon the tunneling conductance formula.
Joshi, Hima S. "Conjugated phenanthrolines and metal-containing DNA as luminescent probes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3007141.
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